MUC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)9.33324820
2aminoglycoside antibiotic metabolic process (GO:0030647)9.32819031
3female mating behavior (GO:0060180)8.05580038
4sexual reproduction (GO:0019953)7.82085783
5lung epithelium development (GO:0060428)5.90368500
6semaphorin-plexin signaling pathway (GO:0071526)5.71785560
7detection of molecule of bacterial origin (GO:0032490)5.65375120
8sulfate transmembrane transport (GO:1902358)5.62313857
9* maintenance of gastrointestinal epithelium (GO:0030277)5.54988904
10negative regulation of macroautophagy (GO:0016242)5.49560250
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.46702104
12stress granule assembly (GO:0034063)5.28904587
13collecting duct development (GO:0072044)5.26675050
14digestion (GO:0007586)5.13222139
15regulation of establishment or maintenance of cell polarity (GO:0032878)5.12940915
16post-embryonic morphogenesis (GO:0009886)4.99701386
17lung secretory cell differentiation (GO:0061140)4.89406134
18bicarbonate transport (GO:0015701)4.67813554
19auditory receptor cell stereocilium organization (GO:0060088)4.55184191
20positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.51075350
21sulfate transport (GO:0008272)4.48393627
22establishment of epithelial cell polarity (GO:0090162)4.38571005
23positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.32073419
24urogenital system development (GO:0001655)4.28289110
25metanephric tubule development (GO:0072170)4.26036910
26metanephric nephron tubule development (GO:0072234)4.26036910
27* epithelial structure maintenance (GO:0010669)4.23090279
28endothelial cell chemotaxis (GO:0035767)4.15358597
29* O-glycan processing (GO:0016266)4.10800454
30cellular anion homeostasis (GO:0030002)4.09237165
31positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.06637641
32energy homeostasis (GO:0097009)4.03666331
33metanephric nephron epithelium development (GO:0072243)3.94331515
34insulin-like growth factor receptor signaling pathway (GO:0048009)3.93887292
35detection of external biotic stimulus (GO:0098581)3.75654111
36positive regulation of neurological system process (GO:0031646)3.74440604
37negative regulation of T cell differentiation in thymus (GO:0033085)3.71896611
38cranial nerve structural organization (GO:0021604)3.68088331
39C21-steroid hormone biosynthetic process (GO:0006700)3.67508789
40* digestive system process (GO:0022600)3.66892510
41regulation of phospholipase A2 activity (GO:0032429)3.65024963
42lung epithelial cell differentiation (GO:0060487)3.60521723
43proline metabolic process (GO:0006560)3.59635243
44protein autoprocessing (GO:0016540)3.59298534
45metanephric epithelium development (GO:0072207)3.58925604
46regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.58176132
47regulation of cholesterol homeostasis (GO:2000188)3.57094012
48regulation of bile acid biosynthetic process (GO:0070857)3.56641653
49negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.53256671
50extracellular fibril organization (GO:0043206)3.52133253
51phosphate ion homeostasis (GO:0055062)3.49949327
52trivalent inorganic anion homeostasis (GO:0072506)3.49949327
53facial nerve structural organization (GO:0021612)3.48610985
54negative regulation of cell size (GO:0045792)3.47466771
55response to iron ion (GO:0010039)3.46904437
56kidney morphogenesis (GO:0060993)3.40331000
57lung cell differentiation (GO:0060479)3.39276003
58face development (GO:0060324)3.38391482
59intestinal absorption (GO:0050892)3.37230629
60lateral ventricle development (GO:0021670)3.34601270
61desmosome organization (GO:0002934)3.34458334
62regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.33111381
63positive regulation of gene expression, epigenetic (GO:0045815)3.32987055
64exogenous drug catabolic process (GO:0042738)3.29650077
65negative regulation of digestive system process (GO:0060457)3.27647107
66regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.27372100
67sulfur compound transport (GO:0072348)3.24843111
68detection of biotic stimulus (GO:0009595)3.21462288
69regulation of proton transport (GO:0010155)3.21058110
70regulation of pH (GO:0006885)3.20950177
71outflow tract septum morphogenesis (GO:0003148)3.19862872
72regulation of ARF GTPase activity (GO:0032312)3.18652199
73nephron tubule development (GO:0072080)3.17527127
74positive regulation of histone deacetylation (GO:0031065)3.17069637
75pattern specification involved in kidney development (GO:0061004)3.14471330
76sulfation (GO:0051923)3.13464806
77planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11702912
78musculoskeletal movement (GO:0050881)3.11342782
79multicellular organismal movement (GO:0050879)3.11342782
80regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.10450542
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.09118594
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.09118594
83regulation of extracellular matrix disassembly (GO:0010715)3.07807099
84regulation of somitogenesis (GO:0014807)3.07720423
85intestinal epithelial cell development (GO:0060576)3.07609283
86ventricular cardiac muscle cell action potential (GO:0086005)3.06632520
87regulation of interleukin-6 biosynthetic process (GO:0045408)3.06353652
88fibroblast migration (GO:0010761)3.05745017
89histone H3-K9 demethylation (GO:0033169)3.04669962
90drug catabolic process (GO:0042737)3.02239640
91fibril organization (GO:0097435)3.01915797
92regulation of hydrogen peroxide metabolic process (GO:0010310)2.99349707
93nephron epithelium morphogenesis (GO:0072088)2.93451630
94nephron tubule morphogenesis (GO:0072078)2.93451630
95neuron remodeling (GO:0016322)2.92752291
96histone H3-K4 trimethylation (GO:0080182)2.92642324
97glutathione derivative biosynthetic process (GO:1901687)2.92505378
98glutathione derivative metabolic process (GO:1901685)2.92505378
99hemidesmosome assembly (GO:0031581)2.90187267
100embryonic foregut morphogenesis (GO:0048617)2.87559841
101multicellular organismal reproductive behavior (GO:0033057)2.87147826
102* protein O-linked glycosylation (GO:0006493)2.85619146
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79891936
104positive regulation of protein kinase C signaling (GO:0090037)2.78050448
105negative regulation of meiosis (GO:0045835)2.75119259
106neural tube development (GO:0021915)2.73840468
107regulation of ruffle assembly (GO:1900027)2.73596151
108inner ear receptor stereocilium organization (GO:0060122)2.73451728
109regulation of translation, ncRNA-mediated (GO:0045974)2.73415923
110negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73415923
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.73415923
112nephron tubule formation (GO:0072079)2.73214962
113renal tubule development (GO:0061326)2.72917351
114white fat cell differentiation (GO:0050872)2.72669901
115regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71859401
116diacylglycerol metabolic process (GO:0046339)2.68702141
117glycoside metabolic process (GO:0016137)2.68246835
118regulation of skeletal muscle contraction (GO:0014819)2.66091594
119cell-cell junction maintenance (GO:0045217)2.66079237
120gonadal mesoderm development (GO:0007506)2.62786475
121regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62103184
122regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.61981004
123negative regulation of catenin import into nucleus (GO:0035414)2.59612611
124atrioventricular valve morphogenesis (GO:0003181)2.58851547
125peptidyl-lysine dimethylation (GO:0018027)2.57722856
126regulation of activation of Janus kinase activity (GO:0010533)2.56436854
127nephron epithelium development (GO:0072009)2.54455605
128urinary tract smooth muscle contraction (GO:0014848)2.53999078
129diol metabolic process (GO:0034311)2.53721238
130cranial nerve morphogenesis (GO:0021602)2.53455761
131synaptic vesicle docking involved in exocytosis (GO:0016081)2.53098484
1324-hydroxyproline metabolic process (GO:0019471)2.52595446
133regulation of hippo signaling (GO:0035330)2.51103318
134sphingosine metabolic process (GO:0006670)2.49729374
135positive thymic T cell selection (GO:0045059)2.48976177
136vitamin transport (GO:0051180)2.48758485
137regulation of heart rate by cardiac conduction (GO:0086091)2.48595080
138cell communication involved in cardiac conduction (GO:0086065)2.47441051
139nitric oxide biosynthetic process (GO:0006809)2.44642295
140positive regulation of glycolytic process (GO:0045821)2.43829899
141cardiac conduction (GO:0061337)2.42782290
142negative regulation of glial cell proliferation (GO:0060253)2.41282448
143positive regulation of neurotransmitter secretion (GO:0001956)2.40872582
144phosphatidylinositol 3-kinase signaling (GO:0014065)2.40252781
145glucocorticoid receptor signaling pathway (GO:0042921)2.40094020
146positive regulation of prostaglandin secretion (GO:0032308)2.40024894
147positive regulation of protein deacetylation (GO:0090312)2.38484742
148anatomical structure arrangement (GO:0048532)2.37950665
149thyroid hormone metabolic process (GO:0042403)2.37861625
150negative regulation of interleukin-1 beta production (GO:0032691)2.37349850
151histone H3-K9 methylation (GO:0051567)2.37308252
152positive regulation of vascular permeability (GO:0043117)2.36907990
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36792647
154embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36073797
155positive regulation of hormone biosynthetic process (GO:0046886)2.35846534
156prostanoid metabolic process (GO:0006692)2.35449088
157prostaglandin metabolic process (GO:0006693)2.35449088
158embryonic camera-type eye morphogenesis (GO:0048596)2.35214922
159histone H3-K4 methylation (GO:0051568)2.35115445
160adherens junction assembly (GO:0034333)2.34865960
161phosphatidylserine acyl-chain remodeling (GO:0036150)2.34633622
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.33510134
163cellular modified amino acid catabolic process (GO:0042219)2.33292216
164negative regulation of metanephros development (GO:0072217)2.32943848
165glucocorticoid biosynthetic process (GO:0006704)2.32441194
166spinal cord development (GO:0021510)2.32179584
167positive regulation of Rho GTPase activity (GO:0032321)2.30456898
168cell volume homeostasis (GO:0006884)2.30161149
169hepatocyte apoptotic process (GO:0097284)2.29951391
170histone H3-K9 modification (GO:0061647)2.29842180
171definitive hemopoiesis (GO:0060216)2.29383257
172G-protein coupled receptor internalization (GO:0002031)2.29081774
173neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29068353
174neuromuscular process controlling posture (GO:0050884)2.28575814
175protein heterotrimerization (GO:0070208)2.28118424
176glandular epithelial cell differentiation (GO:0002067)2.25574035
177positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25561202
178regulation of apoptotic process involved in morphogenesis (GO:1902337)2.23829919
179positive regulation vascular endothelial growth factor production (GO:0010575)2.23690917
180heart morphogenesis (GO:0003007)2.23470100
181regulation of cardioblast differentiation (GO:0051890)2.20211233
182neutrophil mediated immunity (GO:0002446)2.19141636
183negative regulation of interleukin-1 production (GO:0032692)2.17753105
184growth hormone secretion (GO:0030252)2.17752781
185negative regulation of response to nutrient levels (GO:0032108)2.17274550
186negative regulation of response to extracellular stimulus (GO:0032105)2.17274550
187drinking behavior (GO:0042756)2.15780067
188positive regulation of CREB transcription factor activity (GO:0032793)2.15122965
189positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.14726800
190icosanoid transport (GO:0071715)2.13325501
191polyketide metabolic process (GO:0030638)14.5762780
192doxorubicin metabolic process (GO:0044598)14.5762780
193daunorubicin metabolic process (GO:0044597)14.5762780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57970707
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.44030585
3* LXR_22292898_ChIP-Seq_THP-1_Human2.37745060
4EZH2_22144423_ChIP-Seq_EOC_Human2.35113973
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.28002483
6* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.27944596
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26796766
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.25489698
9RACK7_27058665_Chip-Seq_MCF-7_Human2.23781799
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.23520401
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15702381
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02859166
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02828528
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.00307522
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94555554
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89684643
17KDM2B_26808549_Chip-Seq_DND41_Human1.87751169
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85829441
19DROSHA_22980978_ChIP-Seq_HELA_Human1.85471298
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.81882713
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.81187928
22RXR_22108803_ChIP-Seq_LS180_Human1.79911630
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78090008
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77118670
25NFIB_24661679_ChIP-Seq_LUNG_Mouse1.75651888
26* GATA4_25053715_ChIP-Seq_YYC3_Human1.75588895
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73316489
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73245147
29TCF7_22412390_ChIP-Seq_EML_Mouse1.71985200
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.70439082
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.68425821
32GBX2_23144817_ChIP-Seq_PC3_Human1.63840260
33EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61413196
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.61377490
35CREB1_26743006_Chip-Seq_LNCaP_Human1.61102582
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59394295
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58377779
38TP53_22127205_ChIP-Seq_IMR90_Human1.57545608
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.54208202
40* SMC4_20622854_ChIP-Seq_HELA_Human1.53672104
41* CTCF_27219007_Chip-Seq_Bcells_Human1.52418092
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51669096
43P68_20966046_ChIP-Seq_HELA_Human1.50197818
44* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47948093
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46539437
46SOX2_20726797_ChIP-Seq_SW620_Human1.45770813
47CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43535487
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.42290029
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41580070
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41580070
51GATA6_25053715_ChIP-Seq_YYC3_Human1.40634582
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37784586
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.35798375
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33828421
55* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33753785
56IGF1R_20145208_ChIP-Seq_DFB_Human1.30935317
57* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.29831434
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.28643837
59AHR_22903824_ChIP-Seq_MCF-7_Human1.26973518
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26909472
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26627641
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25937083
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25387548
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.24458260
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23999504
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.23664229
67GATA1_19941826_ChIP-Seq_K562_Human1.23506327
68TP53_16413492_ChIP-PET_HCT116_Human1.22967449
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22914990
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.22316180
71STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.22169300
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21708382
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.21641662
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21489701
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19582822
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19228200
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18507097
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.16968461
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16934481
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16666649
81VDR_24787735_ChIP-Seq_THP-1_Human1.15802538
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14863841
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.14590596
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.14431759
85GATA2_19941826_ChIP-Seq_K562_Human1.13942447
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13808832
87* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13597862
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13102726
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.12919065
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12909952
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12300826
92* TP63_22573176_ChIP-Seq_HFKS_Human1.11019546
93KLF5_25053715_ChIP-Seq_YYC3_Human1.10991359
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.10197484
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09635050
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09155710
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09154074
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.08931355
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.08893559
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.08598168
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07134694
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07001877
103* BCOR_27268052_Chip-Seq_Bcells_Human1.06873282
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06534452
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06519081
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.06104988
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05822696
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05261984
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05115239
110BCAT_22108803_ChIP-Seq_LS180_Human1.04770319
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.04637296
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04374486
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.03979225
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03946067
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.03710151
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03678292
117P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03404773
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.03185921
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.02075186
120TET1_21451524_ChIP-Seq_MESCs_Mouse1.01904831
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01531556
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.01389372
123MYC_27129775_Chip-Seq_CORNEA_Mouse1.00268527
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00002025
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99989764
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99769636
127CJUN_26792858_Chip-Seq_BT549_Human0.99334874
128MYC_22102868_ChIP-Seq_BL_Human0.99040443
129PHF8_20622854_ChIP-Seq_HELA_Human0.98909275
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98663841
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97736730
132TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97650334
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97555708
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97320214
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97262055
136* BCL6_27268052_Chip-Seq_Bcells_Human0.96341728
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.95526757
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95318037
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95317793
140OCT4_19829295_ChIP-Seq_ESCs_Human0.95285311
141KDM2B_26808549_Chip-Seq_K562_Human0.94850088
142ISL1_27105846_Chip-Seq_CPCs_Mouse0.94794623
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94317797
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94117895
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92125763
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92043445
147RUNX1_27514584_Chip-Seq_MCF-7_Human0.91969261
148SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90408104
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90055282
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89685001
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89565457
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.89437219
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87653661
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86421645
155SCL_19346495_ChIP-Seq_HPC-7_Human0.85790589
156CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85232429
157EGR1_19032775_ChIP-ChIP_M12_Human0.85138611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001664_abnormal_digestion4.30453229
2MP0001873_stomach_inflammation4.22751423
3MP0005377_hearing/vestibular/ear_phenot3.93690286
4MP0003878_abnormal_ear_physiology3.93690286
5MP0000470_abnormal_stomach_morphology3.51735121
6MP0005670_abnormal_white_adipose3.01505602
7MP0008872_abnormal_physiological_respon2.87348651
8MP0002249_abnormal_larynx_morphology2.67716583
9MP0001666_abnormal_nutrient_absorption2.31225960
10MP0005503_abnormal_tendon_morphology2.20108720
11MP0000566_synostosis2.19385030
12MP0003938_abnormal_ear_development2.12825934
13MP0010386_abnormal_urinary_bladder2.07156150
14MP0008004_abnormal_stomach_pH15.7182621
15MP0000538_abnormal_urinary_bladder1.86998573
16MP0010234_abnormal_vibrissa_follicle1.85194574
17MP0001663_abnormal_digestive_system1.85098468
18MP0004036_abnormal_muscle_relaxation1.85047102
19MP0002822_catalepsy1.76896934
20MP0004145_abnormal_muscle_electrophysio1.70896077
21MP0001501_abnormal_sleep_pattern1.69025585
22MP0005381_digestive/alimentary_phenotyp1.68901309
23MP0004264_abnormal_extraembryonic_tissu1.67724900
24MP0002108_abnormal_muscle_morphology1.67316441
25MP0003879_abnormal_hair_cell1.56518150
26MP0005645_abnormal_hypothalamus_physiol1.56187987
27MP0002089_abnormal_postnatal_growth/wei1.53443206
28MP0008875_abnormal_xenobiotic_pharmacok1.52469257
29MP0001270_distended_abdomen1.48144376
30MP0000462_abnormal_digestive_system1.46507787
31MP0003045_fibrosis1.42465670
32MP0003115_abnormal_respiratory_system1.42035225
33MP0000534_abnormal_ureter_morphology1.41793047
34MP0002933_joint_inflammation1.40811155
35MP0002168_other_aberrant_phenotype1.39582011
36MP0003868_abnormal_feces_composition1.38967761
37MP0001958_emphysema1.37692848
38MP0005083_abnormal_biliary_tract1.37040248
39MP0003279_aneurysm1.36253642
40MP0000537_abnormal_urethra_morphology1.36067614
41MP0000678_abnormal_parathyroid_gland1.31909813
42MP0000751_myopathy1.30775860
43MP0000681_abnormal_thyroid_gland1.29691765
44MP0002277_abnormal_respiratory_mucosa1.28926440
45MP0009697_abnormal_copulation1.28345748
46MP0003866_abnormal_defecation1.26328832
47MP0003172_abnormal_lysosome_physiology1.25696194
48MP0000767_abnormal_smooth_muscle1.24338479
49MP0000013_abnormal_adipose_tissue1.21035660
50MP0000003_abnormal_adipose_tissue1.20801027
51MP0005409_darkened_coat_color1.18045857
52MP0002932_abnormal_joint_morphology1.16436880
53MP0003119_abnormal_digestive_system1.15789626
54MP0005220_abnormal_exocrine_pancreas1.15264918
55MP0004147_increased_porphyrin_level1.14141133
56MP0002653_abnormal_ependyma_morphology1.14052700
57MP0003941_abnormal_skin_development1.12935870
58MP0005508_abnormal_skeleton_morphology1.11421632
59MP0001348_abnormal_lacrimal_gland1.07656377
60MP0001756_abnormal_urination1.07092767
61MP0003566_abnormal_cell_adhesion1.03834458
62MP0005165_increased_susceptibility_to1.03736109
63MP0001485_abnormal_pinna_reflex1.03615242
64MP0001502_abnormal_circadian_rhythm1.02588560
65MP0010329_abnormal_lipoprotein_level1.01124667
66MP0002938_white_spotting0.99468232
67MP0000477_abnormal_intestine_morphology0.98414857
68MP0005085_abnormal_gallbladder_physiolo0.98286326
69MP0000747_muscle_weakness0.95535490
70MP0003300_gastrointestinal_ulcer0.95522361
71MP0009278_abnormal_bone_marrow0.95137675
72MP0002116_abnormal_craniofacial_bone0.94343419
73MP0004742_abnormal_vestibular_system0.93889399
74MP0000490_abnormal_crypts_of0.93526430
75MP0005375_adipose_tissue_phenotype0.92411175
76MP0003942_abnormal_urinary_system0.92375271
77MP0003191_abnormal_cellular_cholesterol0.90257687
78MP0005360_urolithiasis0.89673908
79MP0000579_abnormal_nail_morphology0.87370653
80MP0003943_abnormal_hepatobiliary_system0.86877507
81MP0003252_abnormal_bile_duct0.86618938
82MP0005257_abnormal_intraocular_pressure0.85909650
83MP0002796_impaired_skin_barrier0.83111621
84MP0008961_abnormal_basal_metabolism0.81776914
85MP0002925_abnormal_cardiovascular_devel0.81326093
86MP0004924_abnormal_behavior0.80914371
87MP0005386_behavior/neurological_phenoty0.80914371
88MP0000432_abnormal_head_morphology0.80853234
89MP0002138_abnormal_hepatobiliary_system0.80740835
90MP0005666_abnormal_adipose_tissue0.79929052
91MP0010630_abnormal_cardiac_muscle0.79836342
92MP0004185_abnormal_adipocyte_glucose0.79680441
93MP0003453_abnormal_keratinocyte_physiol0.79302002
94MP0002127_abnormal_cardiovascular_syste0.78761558
95MP0003656_abnormal_erythrocyte_physiolo0.78267508
96MP0005448_abnormal_energy_balance0.77292660
97MP0002166_altered_tumor_susceptibility0.77069554
98MP0000026_abnormal_inner_ear0.76862876
99MP0003137_abnormal_impulse_conducting0.75819822
100MP0002896_abnormal_bone_mineralization0.75478053
101MP0008995_early_reproductive_senescence0.73122937
102MP0008874_decreased_physiological_sensi0.71872358
103MP0004133_heterotaxia0.71158056
104MP0010368_abnormal_lymphatic_system0.69786088
105MP0003806_abnormal_nucleotide_metabolis0.69687183
106MP0003948_abnormal_gas_homeostasis0.68565608
107MP0003935_abnormal_craniofacial_develop0.68362976
108MP0005365_abnormal_bile_salt0.68132971
109MP0000230_abnormal_systemic_arterial0.66024057
110MP0005058_abnormal_lysosome_morphology0.65575612
111MP0004858_abnormal_nervous_system0.65546791
112MP0000266_abnormal_heart_morphology0.65053611
113MP0004484_altered_response_of0.64592929
114MP0004019_abnormal_vitamin_homeostasis0.62961877
115MP0000467_abnormal_esophagus_morphology0.62051845
116MP0002098_abnormal_vibrissa_morphology0.61805673
117MP0010678_abnormal_skin_adnexa0.61541532
118MP0010155_abnormal_intestine_physiology0.61266123
119MP0001849_ear_inflammation0.60982488
120MP0009780_abnormal_chondrocyte_physiolo0.60247602
121MP0004510_myositis0.59805004
122MP0006054_spinal_hemorrhage0.57642623
123MP0005310_abnormal_salivary_gland0.56279229
124MP0003705_abnormal_hypodermis_morpholog0.55608978
125MP0003950_abnormal_plasma_membrane0.54779295
126MP0001486_abnormal_startle_reflex0.54048783
127MP0002396_abnormal_hematopoietic_system0.53711864
128MP0004947_skin_inflammation0.52062013
129MP0005248_abnormal_Harderian_gland0.51656027
130MP0005501_abnormal_skin_physiology0.51312400
131MP0005423_abnormal_somatic_nervous0.50321689
132MP0000733_abnormal_muscle_development0.48398434
133MP0001881_abnormal_mammary_gland0.46954810
134MP0003283_abnormal_digestive_organ0.45280721
135MP0001216_abnormal_epidermal_layer0.44503509
136MP0002060_abnormal_skin_morphology0.42275305
137MP0003646_muscle_fatigue0.41216121
138MP0001440_abnormal_grooming_behavior0.40521409
139MP0003183_abnormal_peptide_metabolism0.39995615
140MP0008775_abnormal_heart_ventricle0.39695286
141MP0000609_abnormal_liver_physiology0.39276824
142MP0003075_altered_response_to0.39183909
143MP0002909_abnormal_adrenal_gland0.39100768
144MP0001346_abnormal_lacrimal_gland0.38661923
145MP0000427_abnormal_hair_cycle0.38642339
146MP0003638_abnormal_response/metabolism_0.38508038
147MP0000516_abnormal_urinary_system0.38071166
148MP0005367_renal/urinary_system_phenotyp0.38071166
149MP0005167_abnormal_blood-brain_barrier0.37467431
150MP0000613_abnormal_salivary_gland0.36520766
151MP0000627_abnormal_mammary_gland0.36274682
152MP0002118_abnormal_lipid_homeostasis0.36252674
153MP0005076_abnormal_cell_differentiation0.35895432
154MP0001765_abnormal_ion_homeostasis0.35536829
155MP0002998_abnormal_bone_remodeling0.34585336
156MP0002928_abnormal_bile_duct0.34563995
157MP0003828_pulmonary_edema0.34416701
158MP0002132_abnormal_respiratory_system0.33479093
159MP0004084_abnormal_cardiac_muscle0.32627934
160MP0000762_abnormal_tongue_morphology0.31073651
161MP0005166_decreased_susceptibility_to0.30063746
162MP0002113_abnormal_skeleton_development0.29948258
163MP0005334_abnormal_fat_pad0.29404280
164MP0010771_integument_phenotype0.29358331
165MP0003795_abnormal_bone_structure0.28602049
166MP0004043_abnormal_pH_regulation0.26676393
167MP0003953_abnormal_hormone_level0.26339524
168MP0004085_abnormal_heartbeat0.25306256
169MP0001845_abnormal_inflammatory_respons0.25239690

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)7.72230570
2Unilateral renal agenesis (HP:0000122)7.17917542
3Parakeratosis (HP:0001036)7.05106069
4Bilateral sensorineural hearing impairment (HP:0008619)6.57873778
5Genetic anticipation (HP:0003743)6.09541806
6Right ventricular cardiomyopathy (HP:0011663)5.93292470
7Follicular hyperkeratosis (HP:0007502)5.85945118
8Cheilitis (HP:0100825)5.39130827
9Ependymoma (HP:0002888)5.31086103
10Abnormality of dental color (HP:0011073)4.99777553
11Absent eyebrow (HP:0002223)4.99010941
12Absent eyelashes (HP:0000561)4.89942913
13Cerebral aneurysm (HP:0004944)4.78059550
14Progressive cerebellar ataxia (HP:0002073)4.50634450
15Obstructive sleep apnea (HP:0002870)4.25773030
16Neoplasm of the heart (HP:0100544)4.23165090
17Bronchomalacia (HP:0002780)4.14334996
18Recurrent corneal erosions (HP:0000495)4.13373282
19Hyperphosphatemia (HP:0002905)4.04016041
20Abnormality of the astrocytes (HP:0100707)3.84855738
21Astrocytoma (HP:0009592)3.84855738
22Broad face (HP:0000283)3.71905072
23Syncope (HP:0001279)3.66357208
24Rectal prolapse (HP:0002035)3.55158595
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.53190416
26Thin bony cortex (HP:0002753)3.50980405
27Abnormal number of erythroid precursors (HP:0012131)3.45125485
28Abnormality of the ischium (HP:0003174)3.44410729
29Blepharitis (HP:0000498)3.42889979
30Chronic otitis media (HP:0000389)3.40316022
31Abolished electroretinogram (ERG) (HP:0000550)3.33912695
32Broad metatarsal (HP:0001783)3.29957009
33Abnormality of the fingertips (HP:0001211)3.25685319
34Dynein arm defect of respiratory motile cilia (HP:0012255)3.22514999
35Absent/shortened dynein arms (HP:0200106)3.22514999
36Ectropion (HP:0000656)3.16100931
37Lymphangioma (HP:0100764)3.15611641
38Plantar hyperkeratosis (HP:0007556)3.14606246
39Abnormality of the vitamin B12 metabolism (HP:0004341)3.06226595
40Stomach cancer (HP:0012126)3.03946408
41Tetany (HP:0001281)3.00619675
42Conjugated hyperbilirubinemia (HP:0002908)2.99019193
43Glioma (HP:0009733)2.83782568
44Abnormality of vitamin B metabolism (HP:0004340)2.79488198
45Sparse lateral eyebrow (HP:0005338)2.73689128
46Aneurysm (HP:0002617)2.72637959
47Impaired smooth pursuit (HP:0007772)2.70521630
48Bell-shaped thorax (HP:0001591)2.69717974
49Abnormality of cells of the erythroid lineage (HP:0012130)2.68835103
50Laryngomalacia (HP:0001601)2.67587940
51Shallow orbits (HP:0000586)2.64243519
52Aortic regurgitation (HP:0001659)2.62719948
53Long eyelashes (HP:0000527)2.60928154
54Palmoplantar hyperkeratosis (HP:0000972)2.60756263
55Atrophic scars (HP:0001075)2.59766833
56Abnormal vertebral ossification (HP:0100569)2.58543942
57Shawl scrotum (HP:0000049)2.58524331
58Visceral angiomatosis (HP:0100761)2.58040960
59Erythroderma (HP:0001019)2.55237254
60Tracheomalacia (HP:0002779)2.51205554
61Neoplasm of the lung (HP:0100526)2.50096901
62Abnormality of the aortic arch (HP:0012303)2.45375442
63Palmar hyperkeratosis (HP:0010765)2.41193633
64Nuclear cataract (HP:0100018)2.40918581
65Abnormality of the pubic bones (HP:0003172)2.38678892
66Abnormality of proline metabolism (HP:0010907)2.36388046
67Hydroxyprolinuria (HP:0003080)2.36388046
68Ileus (HP:0002595)2.34513336
69Vascular calcification (HP:0004934)2.34194236
70Hemangiomatosis (HP:0007461)2.32157322
71Hyperacusis (HP:0010780)2.28924094
72Renal dysplasia (HP:0000110)2.26738439
73Milia (HP:0001056)2.25116233
74Onycholysis (HP:0001806)2.24176836
75Megaloblastic anemia (HP:0001889)2.23937533
76Urticaria (HP:0001025)2.22663392
77Germ cell neoplasia (HP:0100728)2.20778237
78Mitral stenosis (HP:0001718)2.20534095
79Anal stenosis (HP:0002025)2.20006731
80Cardiovascular calcification (HP:0011915)2.17235080
81Vertebral arch anomaly (HP:0008438)2.16667161
82Small epiphyses (HP:0010585)2.15887503
83Abnormality of vitamin metabolism (HP:0100508)2.14495816
84Pigmentary retinal degeneration (HP:0001146)2.13418299
85Absent hair (HP:0002298)2.11693344
86Lip pit (HP:0100267)2.10767440
87Dysmetric saccades (HP:0000641)2.08487076
88Neoplasm of the respiratory system (HP:0100606)2.06609256
89Ventricular fibrillation (HP:0001663)2.06033842
90Cervical subluxation (HP:0003308)2.04109538
91Atrial fibrillation (HP:0005110)2.00934622
92Macroorchidism (HP:0000053)2.00681410
93Congenital sensorineural hearing impairment (HP:0008527)1.99907735
94Prolonged QT interval (HP:0001657)1.99900731
95Hyperventilation (HP:0002883)1.96916816
96Clumsiness (HP:0002312)1.96836548
97Diplopia (HP:0000651)1.96702012
98Abnormality of binocular vision (HP:0011514)1.96702012
99Morphological abnormality of the middle ear (HP:0008609)1.96615204
100Ureteral stenosis (HP:0000071)1.95150883
101Ventricular tachycardia (HP:0004756)1.94819756
102Malnutrition (HP:0004395)1.94525673
103Potter facies (HP:0002009)1.94516154
104Facial shape deformation (HP:0011334)1.94516154
105Abnormality of chloride homeostasis (HP:0011422)1.94307645
106Metaphyseal cupping (HP:0003021)1.93789328
107Aortic dissection (HP:0002647)1.93733360
108Cupped ribs (HP:0000887)1.93117892
109Bicornuate uterus (HP:0000813)1.93063353
110Acanthocytosis (HP:0001927)1.92967577
111Abnormality of carpal bone ossification (HP:0006257)1.92042972
112Keratitis (HP:0000491)1.91856573
113Vertigo (HP:0002321)1.90930152
114Arterial tortuosity (HP:0005116)1.90639132
115Plagiocephaly (HP:0001357)1.89284704
116Corneal erosion (HP:0200020)1.89245023
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.88855029
118Nail dystrophy (HP:0008404)1.88417772
119Aplasia cutis congenita (HP:0001057)1.87058268
120Flattened epiphyses (HP:0003071)1.86919436
121J-shaped sella turcica (HP:0002680)1.85920304
122Hyperactive renin-angiotensin system (HP:0000841)1.85509592
123Abnormality of ocular smooth pursuit (HP:0000617)1.84816248
124Primary atrial arrhythmia (HP:0001692)1.84747648
125Cystic liver disease (HP:0006706)1.84647641
126Persistence of primary teeth (HP:0006335)1.82977528
127Abnormality of calcium-phosphate metabolism (HP:0100530)1.82628895
128Abnormality of the gastric mucosa (HP:0004295)1.81928233
129Ventricular arrhythmia (HP:0004308)1.80495082
130Ulnar bowing (HP:0003031)1.80464510
131Protruding tongue (HP:0010808)1.79982639
132Sudden death (HP:0001699)1.79058455
133Pustule (HP:0200039)1.78319132
134Frequent falls (HP:0002359)1.77666673
135Gaze-evoked nystagmus (HP:0000640)1.76602830
136Urethral obstruction (HP:0000796)1.75082382
137Abnormality of the nasal septum (HP:0000419)1.74305713
138Hypocalcemia (HP:0002901)1.73031622
139Ureteral obstruction (HP:0006000)1.72065787
140Bone pain (HP:0002653)1.71276881
141Renovascular hypertension (HP:0100817)1.70848857
142Woolly hair (HP:0002224)1.70169574
143Oligodontia (HP:0000677)1.70058140
144Supraventricular tachycardia (HP:0004755)1.69281455
145Asymmetry of the thorax (HP:0001555)1.68934525
146Sleep apnea (HP:0010535)1.66655248
147Aortic aneurysm (HP:0004942)1.66627253
148Amelogenesis imperfecta (HP:0000705)1.66587424
149Supernumerary bones of the axial skeleton (HP:0009144)1.65658202
150Abdominal distention (HP:0003270)1.65395149
151Supernumerary ribs (HP:0005815)1.65214111
152Hypoplastic nipples (HP:0002557)1.65077488
153Inability to walk (HP:0002540)1.64597522
154Prostate neoplasm (HP:0100787)1.64510584
155Bowel diverticulosis (HP:0005222)1.64265053
156Supraventricular arrhythmia (HP:0005115)1.63966656
157Abnormality of glutamine family amino acid metabolism (HP:0010902)1.63450017
158Poikilocytosis (HP:0004447)1.62803896
159Distal lower limb amyotrophy (HP:0008944)1.62657325
160Precocious puberty (HP:0000826)1.61370498
161Hypoplastic labia majora (HP:0000059)1.61361180
162Abnormality of the intervertebral disk (HP:0005108)1.61292146
163Curly hair (HP:0002212)1.60462984
164Palpitations (HP:0001962)1.60169801
165Natal tooth (HP:0000695)1.58471119
166Abnormal hand bone ossification (HP:0010660)1.58147985
167Stereotypic behavior (HP:0000733)1.57662651
168Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.57637310
169Hypoplastic ischia (HP:0003175)1.57088038
170Limited hip movement (HP:0008800)1.55733610
171Hemorrhage of the eye (HP:0011885)1.55623244
172Rhinitis (HP:0012384)1.55388187
173Flat acetabular roof (HP:0003180)1.55326874
174Flared iliac wings (HP:0002869)1.55091345
175Vascular tortuosity (HP:0004948)1.54524140
176Hamartoma of the eye (HP:0010568)1.53795308
177Abnormality of incisor morphology (HP:0011063)1.53163043
178Hyperglycinuria (HP:0003108)1.53133074
179Neonatal short-limb short stature (HP:0008921)1.52663228
180Fragile skin (HP:0001030)1.52216419
181Tented upper lip vermilion (HP:0010804)1.51709754
182Narrow palate (HP:0000189)1.50082707
183Abnormal cortical bone morphology (HP:0003103)1.48607357
184Aplasia/Hypoplasia of the sternum (HP:0006714)1.47718990
185Emphysema (HP:0002097)1.45972329
186Absent radius (HP:0003974)1.45970892
187Choanal stenosis (HP:0000452)1.45942513
188Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.45922502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.76988451
2SIK15.56722906
3SIK25.20169711
4ERBB45.07327147
5EPHA24.65140510
6FGFR44.08883729
7AKT33.69494884
8LATS13.33616500
9MATK3.17825141
10MST1R2.86379630
11LMTK22.24473046
12MARK32.21784364
13MST42.19532502
14PAK42.13441069
15PRKCI2.01673583
16TNK21.86768152
17CDK121.83673763
18NTRK31.80860588
19FGFR21.77628260
20TAOK31.56686854
21CDC42BPA1.53426443
22EPHB11.45133783
23MAP2K61.38990989
24NUAK11.38503691
25CAMKK11.32765435
26RIPK11.16592502
27MAP3K61.15167376
28MTOR1.14097373
29MAP2K21.13243274
30PDGFRA1.11898622
31RPS6KA21.08258483
32FRK1.06014289
33PRKG21.03344223
34STK101.02560365
35MAPK151.02294201
36CHUK1.00871505
37FER0.99490645
38MARK20.95269721
39STK38L0.95051841
40RPS6KA60.94032506
41DMPK0.92817483
42PRKAA20.92324718
43STK30.89762620
44TGFBR20.89310548
45LATS20.87262414
46TXK0.87091045
47CDK30.86860948
48CDK80.86600560
49WNK10.85280133
50PTK60.81556985
51PRKCH0.81489413
52INSRR0.80655308
53BRD40.79744986
54MET0.79130610
55GRK10.77356447
56PRKD20.76956842
57RIPK40.76675311
58MAP3K20.74771673
59ERBB20.73645287
60EEF2K0.73264213
61MAP3K130.70763181
62RET0.70512473
63NEK20.69059786
64CAMK1G0.68640188
65FGFR30.66254335
66MAPK80.65957554
67PIK3CG0.64985903
68STK380.63298489
69TYRO30.63103985
70TRIB30.61658241
71CAMK10.59531308
72ALK0.59374450
73TAOK10.58316822
74CAMK1D0.58219125
75PAK20.56929451
76MAP2K10.54420144
77MAP3K70.54109934
78PRKAA10.53321321
79ACVR1B0.50466506
80PKN20.50379148
81ITK0.49935927
82FYN0.49574550
83EPHB20.48352370
84PDGFRB0.48027858
85TESK10.47578866
86CDK150.47491213
87ICK0.47127701
88MAPK10.47059503
89TTN0.46991874
90JAK10.45912345
91CAMK40.45659104
92SGK30.45036859
93CDK11A0.43593321
94ROCK10.43200047
95PTK20.42277586
96MAP3K90.41724194
97CDK180.40971397
98DDR20.40734835
99MAP3K30.40626513
100SRC0.39238390
101GSK3B0.38865994
102MAPK30.38363467
103CSNK1A10.37937329
104PRKG10.36453859
105TBK10.36226405
106EPHA30.36042658
107MAP3K100.35416633
108ERN10.35164634
109NME20.34936684
110DAPK20.34726960
111MAPK100.34146359
112ADRBK20.32952890
113CSNK1D0.31661928
114BMX0.31449683
115MAPK90.30981573
116MAPKAPK20.29826985
117GRK70.29526040
118CSK0.28160548
119MAP3K10.28056344
120CDK50.28032496
121MYLK0.27873691
122PIK3CA0.27814024
123GRK60.27745149
124MAP3K80.27724579
125CSNK1A1L0.27587683
126RPS6KA10.26649597
127BMPR1B0.26588796
128ILK0.26265790
129SGK20.26058619
130AKT10.25531161
131MAPK110.25450159
132BLK0.25169826
133SGK10.24601916
134MAPK70.23835428
135FGR0.23762686
136CDK70.22934638
137MAP3K140.22779064
138KIT0.22278264
139MAPK140.22116374
140CDK60.21702445
141RPS6KA40.21292237
142TTK0.19720714
143CDK40.18564187
144PRKCQ0.17380289
145HCK0.17235052
146RPS6KC10.17083811
147RPS6KL10.17083811
148PKN10.16324362
149ZAP700.16304198
150OBSCN0.15882818
151MAP3K120.15289874
152NME10.14197711
153HIPK20.13684032
154YES10.13399062

Predicted pathways (KEGG)

RankGene SetZ-score
1Gastric acid secretion_Homo sapiens_hsa049713.68974574
2Fat digestion and absorption_Homo sapiens_hsa049753.64977611
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.64930266
4Mineral absorption_Homo sapiens_hsa049783.47006889
5Vitamin digestion and absorption_Homo sapiens_hsa049772.92746559
6Other glycan degradation_Homo sapiens_hsa005112.62757569
7Cocaine addiction_Homo sapiens_hsa050302.47570047
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.44842709
9Collecting duct acid secretion_Homo sapiens_hsa049662.27429270
10Sulfur metabolism_Homo sapiens_hsa009202.11537587
11Chemical carcinogenesis_Homo sapiens_hsa052042.08693241
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97835010
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83778723
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76893930
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.70178545
16Histidine metabolism_Homo sapiens_hsa003401.59227627
17Amphetamine addiction_Homo sapiens_hsa050311.57666505
18Glutathione metabolism_Homo sapiens_hsa004801.54610753
19Pancreatic secretion_Homo sapiens_hsa049721.47514125
20Lysine degradation_Homo sapiens_hsa003101.45174858
21Phenylalanine metabolism_Homo sapiens_hsa003601.43630358
22Linoleic acid metabolism_Homo sapiens_hsa005911.43043704
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.37315975
24Choline metabolism in cancer_Homo sapiens_hsa052311.30374155
25Type II diabetes mellitus_Homo sapiens_hsa049301.29076814
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26409285
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22945652
28Prostate cancer_Homo sapiens_hsa052151.21917816
29Dopaminergic synapse_Homo sapiens_hsa047281.21280286
30Nitrogen metabolism_Homo sapiens_hsa009101.18018992
31Ether lipid metabolism_Homo sapiens_hsa005651.07418022
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05866937
33mTOR signaling pathway_Homo sapiens_hsa041501.04582787
34Bile secretion_Homo sapiens_hsa049761.04208276
35Folate biosynthesis_Homo sapiens_hsa007901.03668238
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03315665
37VEGF signaling pathway_Homo sapiens_hsa043701.01559700
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99118351
39Glycerolipid metabolism_Homo sapiens_hsa005610.99036711
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98921114
41Endometrial cancer_Homo sapiens_hsa052130.96207132
42Adherens junction_Homo sapiens_hsa045200.95270974
43Arginine biosynthesis_Homo sapiens_hsa002200.94941945
44Insulin signaling pathway_Homo sapiens_hsa049100.93244127
45Tyrosine metabolism_Homo sapiens_hsa003500.92842754
46Fructose and mannose metabolism_Homo sapiens_hsa000510.92349756
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.91170350
48Non-small cell lung cancer_Homo sapiens_hsa052230.90936504
49Axon guidance_Homo sapiens_hsa043600.88091369
50Thyroid hormone synthesis_Homo sapiens_hsa049180.87714209
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87214565
52Inositol phosphate metabolism_Homo sapiens_hsa005620.86759531
53Circadian entrainment_Homo sapiens_hsa047130.86544162
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86535752
55Prolactin signaling pathway_Homo sapiens_hsa049170.84386733
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83376455
57Hippo signaling pathway_Homo sapiens_hsa043900.83366747
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.82378835
59AMPK signaling pathway_Homo sapiens_hsa041520.81533106
60Melanogenesis_Homo sapiens_hsa049160.80413486
61Renal cell carcinoma_Homo sapiens_hsa052110.80408807
62Osteoclast differentiation_Homo sapiens_hsa043800.79511012
63Glucagon signaling pathway_Homo sapiens_hsa049220.77681568
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74755946
65Dorso-ventral axis formation_Homo sapiens_hsa043200.74535276
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.73223472
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72077312
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71948354
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70876256
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69357359
71Glioma_Homo sapiens_hsa052140.69293574
72Dilated cardiomyopathy_Homo sapiens_hsa054140.69078576
73ABC transporters_Homo sapiens_hsa020100.69052890
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67958631
75Caffeine metabolism_Homo sapiens_hsa002320.67696785
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66677996
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66447440
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65869125
79Salivary secretion_Homo sapiens_hsa049700.65704838
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65139401
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64503069
82Calcium signaling pathway_Homo sapiens_hsa040200.64103818
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63803824
84Proteoglycans in cancer_Homo sapiens_hsa052050.63409232
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62857812
86Renin secretion_Homo sapiens_hsa049240.62129273
87Protein digestion and absorption_Homo sapiens_hsa049740.61358973
88Serotonergic synapse_Homo sapiens_hsa047260.60968407
89Ovarian steroidogenesis_Homo sapiens_hsa049130.60229097
90Glutamatergic synapse_Homo sapiens_hsa047240.58815691
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58197915
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56985791
93Retinol metabolism_Homo sapiens_hsa008300.55493028
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55184881
95MAPK signaling pathway_Homo sapiens_hsa040100.55138466
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55086529
97Oxytocin signaling pathway_Homo sapiens_hsa049210.54559146
98Sphingolipid metabolism_Homo sapiens_hsa006000.54449874
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54431023
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.53569259
101beta-Alanine metabolism_Homo sapiens_hsa004100.52487404
102Toxoplasmosis_Homo sapiens_hsa051450.52409547
103Long-term depression_Homo sapiens_hsa047300.52229427
104African trypanosomiasis_Homo sapiens_hsa051430.51901265
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.51536671
106Hepatitis C_Homo sapiens_hsa051600.51019655
107Renin-angiotensin system_Homo sapiens_hsa046140.50912481
108ECM-receptor interaction_Homo sapiens_hsa045120.50897205
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.50437396
110Tight junction_Homo sapiens_hsa045300.50266918
111Fatty acid degradation_Homo sapiens_hsa000710.50001141
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.49710063
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49479666
114Insulin resistance_Homo sapiens_hsa049310.49186928
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49135328
116ErbB signaling pathway_Homo sapiens_hsa040120.48574602
117Starch and sucrose metabolism_Homo sapiens_hsa005000.48399935
118Arginine and proline metabolism_Homo sapiens_hsa003300.48194228
119Pancreatic cancer_Homo sapiens_hsa052120.47761114
120PPAR signaling pathway_Homo sapiens_hsa033200.47688452
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47276721
122T cell receptor signaling pathway_Homo sapiens_hsa046600.47203023
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.46365852
124Insulin secretion_Homo sapiens_hsa049110.45914789
125Melanoma_Homo sapiens_hsa052180.44802944
126Chronic myeloid leukemia_Homo sapiens_hsa052200.44407092
127Wnt signaling pathway_Homo sapiens_hsa043100.42914389
128MicroRNAs in cancer_Homo sapiens_hsa052060.42729756
129Focal adhesion_Homo sapiens_hsa045100.42084149
130Hematopoietic cell lineage_Homo sapiens_hsa046400.41579721
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41552318
132cAMP signaling pathway_Homo sapiens_hsa040240.41308081
133Rap1 signaling pathway_Homo sapiens_hsa040150.40436073
134Cholinergic synapse_Homo sapiens_hsa047250.40031978
135Ras signaling pathway_Homo sapiens_hsa040140.39636291
136Circadian rhythm_Homo sapiens_hsa047100.39395947
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39066287
138TNF signaling pathway_Homo sapiens_hsa046680.38607592
139Bladder cancer_Homo sapiens_hsa052190.38223856
140Taste transduction_Homo sapiens_hsa047420.36573115
141Small cell lung cancer_Homo sapiens_hsa052220.34606881
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34456376
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34442259
144Notch signaling pathway_Homo sapiens_hsa043300.33477200
145Arachidonic acid metabolism_Homo sapiens_hsa005900.33441931
146Platelet activation_Homo sapiens_hsa046110.33110413
147Salmonella infection_Homo sapiens_hsa051320.32774620
148Estrogen signaling pathway_Homo sapiens_hsa049150.32382117
149GnRH signaling pathway_Homo sapiens_hsa049120.31849335
150Acute myeloid leukemia_Homo sapiens_hsa052210.31441291

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