MUC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epidermal cell differentiation (GO:0009913)9.58794060
2negative regulation of biomineral tissue development (GO:0070168)9.53429947
3apical protein localization (GO:0045176)9.13597127
4negative regulation of homotypic cell-cell adhesion (GO:0034111)8.38140013
5long-chain fatty acid biosynthetic process (GO:0042759)7.78382557
6establishment of skin barrier (GO:0061436)7.49890027
7positive regulation of endothelial cell differentiation (GO:0045603)7.01177529
8membrane raft organization (GO:0031579)6.55790284
9lipoxygenase pathway (GO:0019372)6.51522034
10localization within membrane (GO:0051668)6.49349503
11hair cell differentiation (GO:0035315)6.40433705
12regulation of water loss via skin (GO:0033561)6.27984825
13negative regulation of interleukin-17 production (GO:0032700)6.23372050
14asymmetric protein localization (GO:0008105)6.20049421
15regulation of platelet aggregation (GO:0090330)6.15669821
16linoleic acid metabolic process (GO:0043651)6.11881694
17epidermis development (GO:0008544)5.69509216
18positive regulation of p38MAPK cascade (GO:1900745)5.37238203
19multicellular organismal water homeostasis (GO:0050891)5.31834232
20regulation of mitochondrial depolarization (GO:0051900)5.24149157
21superoxide anion generation (GO:0042554)5.18326638
22positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.13429598
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.12688864
24negative regulation of cell-cell adhesion (GO:0022408)5.06193280
25regulation of endothelial cell differentiation (GO:0045601)4.81152818
26water homeostasis (GO:0030104)4.65526453
27regulation of protein polyubiquitination (GO:1902914)4.61731473
28negative regulation of platelet activation (GO:0010544)4.58123863
29antimicrobial humoral response (GO:0019730)4.50451016
30negative regulation of cytokine-mediated signaling pathway (GO:0001960)4.49844010
31regulation of bile acid biosynthetic process (GO:0070857)4.42988674
32regulation of cholesterol homeostasis (GO:2000188)4.38362424
33positive regulation of chemokine biosynthetic process (GO:0045080)4.34326313
34regulation of integrin-mediated signaling pathway (GO:2001044)4.16935213
35regulation of hippo signaling (GO:0035330)4.14286132
36negative regulation of response to cytokine stimulus (GO:0060761)4.13918541
37positive regulation of vasodilation (GO:0045909)4.01368677
38intestinal epithelial cell development (GO:0060576)3.99523446
39regulation of p38MAPK cascade (GO:1900744)3.90662442
40regulation of interleukin-17 production (GO:0032660)3.82955474
41negative regulation of muscle cell apoptotic process (GO:0010656)3.68437252
42ectoderm development (GO:0007398)3.66284013
43* O-glycan processing (GO:0016266)3.56850796
44regulation of homotypic cell-cell adhesion (GO:0034110)3.56642138
45regulation of interferon-beta biosynthetic process (GO:0045357)3.50392433
46interkinetic nuclear migration (GO:0022027)3.44847906
47N-terminal protein amino acid acetylation (GO:0006474)3.42905816
48early endosome to late endosome transport (GO:0045022)3.34004523
49desmosome organization (GO:0002934)3.27816282
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22254838
51microtubule nucleation (GO:0007020)3.21167334
52eyelid development in camera-type eye (GO:0061029)3.21022855
53hippo signaling (GO:0035329)3.20619964
54regulation of chemokine biosynthetic process (GO:0045073)3.17253168
55vitamin A metabolic process (GO:0006776)3.16718002
56regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.14520980
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.13557527
58wound healing (GO:0042060)3.11889846
59enteric nervous system development (GO:0048484)3.11196113
60regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.08086031
61response to leptin (GO:0044321)3.05483927
62defense response to fungus (GO:0050832)3.00178176
63keratinization (GO:0031424)20.1397481
64negative regulation of cell-substrate adhesion (GO:0010812)2.99696049
65negative regulation of ossification (GO:0030279)2.99258688
66lymph node development (GO:0048535)2.94255403
67negative regulation of interferon-gamma production (GO:0032689)2.89729630
68epithelial cell differentiation (GO:0030855)2.89510831
69biomineral tissue development (GO:0031214)2.88302492
70regulation of bone mineralization (GO:0030500)2.80035773
71regulation of developmental pigmentation (GO:0048070)2.79799317
72epithelium development (GO:0060429)2.77666467
73embryonic process involved in female pregnancy (GO:0060136)2.75877250
74positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75108073
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74362333
76regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.71709120
77regulation of membrane depolarization (GO:0003254)2.70742465
78negative regulation of potassium ion transmembrane transport (GO:1901380)2.67795035
79nephron tubule formation (GO:0072079)2.67029175
80regulation of apoptotic process involved in morphogenesis (GO:1902337)2.65309971
81regulation of biomineral tissue development (GO:0070167)2.64919513
82hypotonic response (GO:0006971)2.64807487
83negative regulation of DNA repair (GO:0045738)2.64509619
84Rho protein signal transduction (GO:0007266)2.63529755
85cytoplasmic mRNA processing body assembly (GO:0033962)2.61942283
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.61355510
87excretion (GO:0007588)2.60269058
88establishment of planar polarity (GO:0001736)2.58867296
89establishment of tissue polarity (GO:0007164)2.58867296
90negative regulation of vascular permeability (GO:0043116)2.58301597
91transepithelial transport (GO:0070633)2.56883372
92regulation of vasodilation (GO:0042312)2.55800923
93sodium ion homeostasis (GO:0055078)2.51766773
94* protein O-linked glycosylation (GO:0006493)2.50994524
95regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.50040806
96regulation of type 2 immune response (GO:0002828)2.49962534
97digestive system process (GO:0022600)2.48025031
98peptide cross-linking (GO:0018149)13.2607675
99keratinocyte differentiation (GO:0030216)11.3673523
100negative regulation of bone mineralization (GO:0030502)10.8155284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.93406568
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.60903139
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.52940011
4ZNF217_24962896_ChIP-Seq_MCF-7_Human3.40256744
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.14062567
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.55715016
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41154408
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.38473774
9FOXO3_23340844_ChIP-Seq_DLD1_Human2.27963562
10FOXM1_26456572_ChIP-Seq_MCF-7_Human2.26886448
11ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human2.24333460
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21001813
13SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20508109
14SOX2_20726797_ChIP-Seq_SW620_Human2.16891368
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12260690
16GATA3_24758297_ChIP-Seq_MCF-7_Human2.11808524
17AHR_22903824_ChIP-Seq_MCF-7_Human2.00454161
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92403174
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91930346
20FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.90336792
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90200485
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90200485
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.90114736
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88225328
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85716515
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85115709
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84278302
28RXR_22108803_ChIP-Seq_LS180_Human1.79622122
29VDR_22108803_ChIP-Seq_LS180_Human1.79599192
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.79286264
31KLF5_25053715_ChIP-Seq_YYC3_Human1.77494464
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.75467178
33CJUN_26792858_Chip-Seq_BT549_Human1.74756815
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.69699514
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68656560
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.66342854
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.64706236
38GATA4_25053715_ChIP-Seq_YYC3_Human1.63599402
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63256525
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.62276963
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.58833558
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.57904564
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.53669412
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51739189
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.50833724
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50103245
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.49938939
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.45142082
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45019851
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44262000
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.41254930
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39179868
53ERG_20517297_ChIP-Seq_VCAP_Human1.38284923
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36882975
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34975876
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29220299
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.26636857
58GATA6_25053715_ChIP-Seq_YYC3_Human1.25352796
59TP63_23658742_ChIP-Seq_EP156T_Human1.24594564
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23959989
61FOXA1_25552417_ChIP-Seq_VCAP_Human1.23293055
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.23084970
63RUNX_20019798_ChIP-Seq_JUKART_Human1.22934072
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20413513
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19869566
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19603230
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17604121
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17213138
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17102585
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15669501
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15610032
72AR_25329375_ChIP-Seq_VCAP_Human1.14060996
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12725691
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12699239
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11701163
76TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11506507
77MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.10575990
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07810982
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07491027
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07114042
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07114042
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.06466911
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.06466911
84RBPJ_21746931_ChIP-Seq_IB4_Human1.05608841
85PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04900167
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03927054
87BRD4_25478319_ChIP-Seq_HGPS_Human1.03835394
88AR_21909140_ChIP-Seq_LNCAP_Human1.02143760
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97945616
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97606738
91AR_21572438_ChIP-Seq_LNCaP_Human0.96953593
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95213105
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94222214
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94056337
95ELF5_23300383_ChIP-Seq_T47D_Human0.93071789
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92230490
97FOXA2_19822575_ChIP-Seq_HepG2_Human0.92088222
98ATF3_27146783_Chip-Seq_COLON_Human0.92042373
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92019442
100SMAD4_21799915_ChIP-Seq_A2780_Human0.91953118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile5.18666417
2MP0002796_impaired_skin_barrier4.90603136
3MP0010352_gastrointestinal_tract_polyps4.82044690
4MP0004043_abnormal_pH_regulation4.12577971
5MP0010678_abnormal_skin_adnexa3.64610273
6MP0005501_abnormal_skin_physiology3.59920156
7MP0004185_abnormal_adipocyte_glucose2.80741438
8MP0009780_abnormal_chondrocyte_physiolo2.62552841
9MP0005670_abnormal_white_adipose2.17347859
10MP0005666_abnormal_adipose_tissue2.01163439
11MP0010234_abnormal_vibrissa_follicle13.0275919
12MP0003705_abnormal_hypodermis_morpholog1.86449815
13MP0002098_abnormal_vibrissa_morphology1.82801434
14MP0003453_abnormal_keratinocyte_physiol1.78992310
15MP0010368_abnormal_lymphatic_system1.77844501
16MP0005503_abnormal_tendon_morphology1.73489324
17MP0009333_abnormal_splenocyte_physiolog1.70282245
18MP0005375_adipose_tissue_phenotype1.60689947
19MP0010771_integument_phenotype1.58619352
20MP0000465_gastrointestinal_hemorrhage1.50537736
21MP0005409_darkened_coat_color1.46560808
22MP0005365_abnormal_bile_salt1.44917845
23MP0001216_abnormal_epidermal_layer1.43670957
24MP0002138_abnormal_hepatobiliary_system1.43294844
25MP0000678_abnormal_parathyroid_gland1.43287167
26MP0004130_abnormal_muscle_cell1.33778174
27MP0001502_abnormal_circadian_rhythm1.32124464
28MP0000467_abnormal_esophagus_morphology1.25552210
29MP0000377_abnormal_hair_follicle1.22365439
30MP0000003_abnormal_adipose_tissue1.13295342
31MP0001851_eye_inflammation1.12961136
32MP0002249_abnormal_larynx_morphology1.08742828
33MP0009115_abnormal_fat_cell1.07874506
34MP0004264_abnormal_extraembryonic_tissu1.04364013
35MP0001765_abnormal_ion_homeostasis0.99997133
36MP0004947_skin_inflammation0.95941400
37MP0001756_abnormal_urination0.93796004
38MP0001784_abnormal_fluid_regulation0.92019234
39MP0000566_synostosis0.88965851
40MP0002166_altered_tumor_susceptibility0.87491741
41MP0000681_abnormal_thyroid_gland0.82264354
42MP0000613_abnormal_salivary_gland0.80434004
43MP0005646_abnormal_pituitary_gland0.78156998
44MP0010386_abnormal_urinary_bladder0.76761815
45MP0005166_decreased_susceptibility_to0.76613459
46MP0000383_abnormal_hair_follicle0.74891691
47MP0001879_abnormal_lymphatic_vessel0.72815235
48MP0002108_abnormal_muscle_morphology0.72319791
49MP0003828_pulmonary_edema0.71975888
50MP0002139_abnormal_hepatobiliary_system0.68744286
51MP0001853_heart_inflammation0.67952357
52MP0000762_abnormal_tongue_morphology0.67507369
53MP0005076_abnormal_cell_differentiation0.64613135
54MP0000733_abnormal_muscle_development0.63908019
55MP0005023_abnormal_wound_healing0.62759436
56MP0006138_congestive_heart_failure0.62528140
57MP0003567_abnormal_fetal_cardiomyocyte0.62463026
58MP0000470_abnormal_stomach_morphology0.61660189
59MP0008961_abnormal_basal_metabolism0.61468512
60MP0000920_abnormal_myelination0.58523970
61MP0001873_stomach_inflammation0.58156666
62MP0002060_abnormal_skin_morphology0.57588680
63MP0001346_abnormal_lacrimal_gland0.57228774
64MP0005636_abnormal_mineral_homeostasis0.57019327
65MP0003938_abnormal_ear_development0.55942616
66MP0003937_abnormal_limbs/digits/tail_de0.55562763
67MP0009384_cardiac_valve_regurgitation0.55388526
68MP0000631_abnormal_neuroendocrine_gland0.54669354
69MP0002136_abnormal_kidney_physiology0.50795240
70MP0000371_diluted_coat_color0.50730728
71MP0008004_abnormal_stomach_pH0.50646395
72MP0000049_abnormal_middle_ear0.50104126
73MP0004885_abnormal_endolymph0.48247274
74MP0009931_abnormal_skin_appearance0.45102522
75MP0009643_abnormal_urine_homeostasis0.44714265
76MP0002006_tumorigenesis0.44686488
77MP0010030_abnormal_orbit_morphology0.43503523
78MP0002876_abnormal_thyroid_physiology0.43271040
79MP0001270_distended_abdomen0.41604826
80MP0003943_abnormal_hepatobiliary_system0.39262240
81MP0003252_abnormal_bile_duct0.38651195
82MP0000367_abnormal_coat/_hair0.38027068
83MP0003724_increased_susceptibility_to0.37958709
84MP0005448_abnormal_energy_balance0.36886811
85MP0002095_abnormal_skin_pigmentation0.36442031
86MP0005451_abnormal_body_composition0.35240961
87MP0001324_abnormal_eye_pigmentation0.35189824
88MP0000462_abnormal_digestive_system0.35111963
89MP0003950_abnormal_plasma_membrane0.35003856
90MP0008995_early_reproductive_senescence0.34365725
91MP0002128_abnormal_blood_circulation0.33932365
92MP0010329_abnormal_lipoprotein_level0.33921539
93MP0001340_abnormal_eyelid_morphology0.33863964
94MP0001544_abnormal_cardiovascular_syste0.33858760
95MP0005385_cardiovascular_system_phenoty0.33858760
96MP0009046_muscle_twitch0.33248329
97MP0002653_abnormal_ependyma_morphology0.33174159
98MP0002970_abnormal_white_adipose0.33013446
99MP0010630_abnormal_cardiac_muscle0.32895262
100MP0002971_abnormal_brown_adipose0.32746376

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.80197126
2Hyperactive renin-angiotensin system (HP:0000841)7.40163734
3Villous atrophy (HP:0011473)6.58987417
4Abnormality of small intestinal villus morphology (HP:0011472)6.58987417
5Lip pit (HP:0100267)6.38443750
6Parakeratosis (HP:0001036)6.22446970
7Hyperkalemia (HP:0002153)5.68856034
8Congenital ichthyosiform erythroderma (HP:0007431)5.30573700
9Decreased circulating renin level (HP:0003351)5.06926161
10Neonatal hypoglycemia (HP:0001998)4.96004146
11Nasal polyposis (HP:0100582)4.93542391
12Erythroderma (HP:0001019)4.89510444
13Hypokalemic alkalosis (HP:0001949)4.79245481
14Chronic bronchitis (HP:0004469)4.58842629
15Sparse scalp hair (HP:0002209)4.57755886
16Eczematoid dermatitis (HP:0000976)4.23795510
17Brittle hair (HP:0002299)4.17814809
18Abnormality of the nasal mucosa (HP:0000433)4.08753725
19Abnormality of renin-angiotensin system (HP:0000847)4.05183488
20Hyperaldosteronism (HP:0000859)4.01514337
21Abnormality of chloride homeostasis (HP:0011422)4.00293315
22Renal salt wasting (HP:0000127)3.73932322
23Cystic hygroma (HP:0000476)3.71793164
24Acanthosis nigricans (HP:0000956)3.49216678
25Dehydration (HP:0001944)3.35556607
26Papillary thyroid carcinoma (HP:0002895)3.24749641
27Oligodontia (HP:0000677)3.09544650
28Increased circulating renin level (HP:0000848)3.03711195
29Oral leukoplakia (HP:0002745)2.98504027
30Erythema (HP:0010783)2.81302964
31Absence seizures (HP:0002121)2.80846402
32Abnormality of potassium homeostasis (HP:0011042)2.69644304
33Abnormality of the salivary glands (HP:0010286)2.61912125
34Furrowed tongue (HP:0000221)2.53848667
35Hoarse voice (HP:0001609)2.46092685
36Emphysema (HP:0002097)2.45915911
37Hyponatremia (HP:0002902)2.42642101
38Delusions (HP:0000746)2.38389320
39Low posterior hairline (HP:0002162)2.34811044
40Hypergammaglobulinemia (HP:0010702)2.32887399
41Oligodactyly (hands) (HP:0001180)2.30063007
42Adrenal overactivity (HP:0002717)2.27976637
43Abnormal pancreas size (HP:0012094)2.23810030
44Alkalosis (HP:0001948)2.23218375
45Verrucae (HP:0200043)2.22001341
46Papilloma (HP:0012740)2.22001341
47Thoracolumbar scoliosis (HP:0002944)2.20369172
48Hypokalemia (HP:0002900)2.18760420
49Stenosis of the external auditory canal (HP:0000402)2.17089154
50Thickened nuchal skin fold (HP:0000474)2.12796623
51Diastasis recti (HP:0001540)2.03927533
52Dialeptic seizures (HP:0011146)2.03665880
53Skin pits (HP:0100276)2.01573482
54Hip dysplasia (HP:0001385)2.01052284
55Right ventricular cardiomyopathy (HP:0011663)2.00565548
56Pustule (HP:0200039)11.2172608
57Increased IgE level (HP:0003212)10.0306780
58Obstructive sleep apnea (HP:0002870)1.99384623
59Acne (HP:0001061)1.97916961
60Malnutrition (HP:0004395)1.96144416
61Nail dystrophy (HP:0008404)1.94529296
62Abnormality of the fingertips (HP:0001211)1.93646817
63Abnormality of sodium homeostasis (HP:0010931)1.90606055
64Autoamputation (HP:0001218)1.90127671
65Urticaria (HP:0001025)1.89222285
66Asthma (HP:0002099)1.88474380
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.88049619
68Fine hair (HP:0002213)1.85396748
69Genetic anticipation (HP:0003743)1.85208535
70Acute myeloid leukemia (HP:0004808)1.83756752
71Labial hypoplasia (HP:0000066)1.83548625
72Bilateral sensorineural hearing impairment (HP:0008619)1.82763109
73Hypoplastic labia majora (HP:0000059)1.76855942
74Choroideremia (HP:0001139)1.76195178
75Oligodactyly (HP:0012165)1.74811279
76Thyroid carcinoma (HP:0002890)1.73842482
77Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.70755498
78Melanocytic nevus (HP:0000995)1.70691310
79Ectropion (HP:0000656)1.68863744
80Asymmetry of the thorax (HP:0001555)1.67893502
81Abnormality of macular pigmentation (HP:0008002)1.66884346
82Hypoplastic female external genitalia (HP:0012815)1.64832539
83Webbed neck (HP:0000465)1.62814313
84Long eyelashes (HP:0000527)1.62051623
85Advanced eruption of teeth (HP:0006288)1.61504170
86Distal lower limb muscle weakness (HP:0009053)1.61106575
87Metabolic alkalosis (HP:0200114)1.60023356
88Abnormality of the labia majora (HP:0012881)1.59587989
89Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.58720690
90Coarse hair (HP:0002208)1.56231312
91Urethral obstruction (HP:0000796)1.56122363
92Curly hair (HP:0002212)1.56037111
93Split foot (HP:0001839)1.55949425
94Abnormality of the columella (HP:0009929)1.55728664
95Bronchitis (HP:0012387)1.54938032
96Prominent nose (HP:0000448)1.54548116
97Radioulnar synostosis (HP:0002974)1.53499341
98Seborrheic dermatitis (HP:0001051)1.51402150
99Hypomagnesemia (HP:0002917)1.51313643
100Abnormality of nail color (HP:0100643)1.50059361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.20594630
2CAMK1D4.42672741
3CAMK1G3.66646762
4STK393.65870257
5WNK43.50358040
6NME13.37709246
7WNK13.37089300
8TYRO33.12598428
9SGK22.96274882
10SGK32.82016088
11MST42.70560349
12LRRK22.69967791
13MAP3K22.48648688
14RIPK12.29514436
15SGK2232.18162297
16SGK4942.18162297
17LATS11.93846662
18STK241.73972171
19MARK21.70896431
20DAPK21.57449692
21BCR1.37999374
22FGFR11.33708928
23AKT31.31749764
24PDGFRB1.29857129
25OXSR11.15940635
26CDK121.12090491
27MET1.07672720
28AKT21.06557678
29CSK1.02819472
30MAP3K71.00885912
31TRPM71.00227976
32PRKAA20.99515220
33STK30.99395148
34TAOK10.96152344
35KSR20.94518567
36PIK3CA0.94294276
37STK380.93870532
38ICK0.86753029
39MAP3K30.86301466
40CHUK0.85097681
41IRAK10.84957978
42ERBB30.81660920
43RPS6KB10.77285454
44MTOR0.74327780
45MAP3K40.72179377
46EPHA20.70661905
47SGK10.69727930
48CAMK40.69196812
49WNK30.68130625
50RPS6KA20.67048060
51SIK30.66435957
52HIPK20.65595232
53IKBKE0.65367406
54CDK90.65037813
55DMPK0.64315772
56IRAK20.63205578
57NEK20.56949287
58MAP3K10.56066271
59MELK0.55442233
60MAP3K120.52700028
61PTK20.52350433
62PINK10.50613789
63IRAK40.50311097
64CDK30.49994540
65CAMK10.48991153
66MAPK10.45222191
67SIK20.45098013
68AURKB0.41426898
69RPS6KA10.40871038
70CSNK1A1L0.40105188
71MAP2K10.39146852
72ATM0.38469225
73PRKAA10.37236438
74AKT10.36926585
75NLK0.36313874
76STK40.34783233
77PRKD30.33402732
78MAPK30.32916218
79ITK0.32200183
80FER0.31692167
81TNIK0.31519431
82STK38L0.30841841
83STK110.29441593
84GSK3B0.29043375
85PRKD20.28207343
86PRKCZ0.28168266
87RPS6KA30.27613474
88MAPKAPK50.26518097
89ZAP700.25324356
90BRD40.25006427
91PRKCH0.24356839
92MST1R0.22876884
93ROCK10.21358099
94CSNK2A20.21145500
95TAOK30.20915744
96RET0.20786809
97PRKDC0.19351840
98MAPK140.19088239
99STK100.19032355
100PIM10.18473149

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047104.90422091
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049604.12440913
3Adherens junction_Homo sapiens_hsa045203.04792660
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39667469
5Notch signaling pathway_Homo sapiens_hsa043302.38600562
6* Salivary secretion_Homo sapiens_hsa049702.36509651
7Arachidonic acid metabolism_Homo sapiens_hsa005902.22563622
8Collecting duct acid secretion_Homo sapiens_hsa049662.05301547
9Tight junction_Homo sapiens_hsa045301.99125558
10Thyroid cancer_Homo sapiens_hsa052161.86839646
11Renal cell carcinoma_Homo sapiens_hsa052111.72730100
12Acute myeloid leukemia_Homo sapiens_hsa052211.68329035
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.61051960
14Vibrio cholerae infection_Homo sapiens_hsa051101.60570611
15Dorso-ventral axis formation_Homo sapiens_hsa043201.58770796
16Lysine degradation_Homo sapiens_hsa003101.48372374
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36622046
18Prostate cancer_Homo sapiens_hsa052151.33927504
19Sulfur metabolism_Homo sapiens_hsa009201.30598866
20Endometrial cancer_Homo sapiens_hsa052131.26707963
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26013435
22Endocytosis_Homo sapiens_hsa041441.25216209
23FoxO signaling pathway_Homo sapiens_hsa040681.19146519
24Serotonergic synapse_Homo sapiens_hsa047261.18343199
25Insulin signaling pathway_Homo sapiens_hsa049101.18069346
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.16761135
27Chronic myeloid leukemia_Homo sapiens_hsa052201.15994019
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14307555
29Long-term potentiation_Homo sapiens_hsa047201.14194809
30Hippo signaling pathway_Homo sapiens_hsa043901.13415758
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12447908
32Insulin resistance_Homo sapiens_hsa049311.09188331
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08322749
34ErbB signaling pathway_Homo sapiens_hsa040121.07344780
35Wnt signaling pathway_Homo sapiens_hsa043101.05934058
36Prolactin signaling pathway_Homo sapiens_hsa049171.05659650
37Hepatitis C_Homo sapiens_hsa051601.04687057
38Amoebiasis_Homo sapiens_hsa051461.02217716
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.02062893
40Salmonella infection_Homo sapiens_hsa051320.97301685
41Inositol phosphate metabolism_Homo sapiens_hsa005620.96862028
42Glucagon signaling pathway_Homo sapiens_hsa049220.96497042
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95660658
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92148382
45TGF-beta signaling pathway_Homo sapiens_hsa043500.92068864
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90773762
47Non-small cell lung cancer_Homo sapiens_hsa052230.89498396
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85779972
49Synaptic vesicle cycle_Homo sapiens_hsa047210.84347737
50Ras signaling pathway_Homo sapiens_hsa040140.83959518
51Influenza A_Homo sapiens_hsa051640.82671449
52AMPK signaling pathway_Homo sapiens_hsa041520.82642678
53GnRH signaling pathway_Homo sapiens_hsa049120.82234148
54Choline metabolism in cancer_Homo sapiens_hsa052310.80649410
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80108102
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79234376
57Glutathione metabolism_Homo sapiens_hsa004800.78777385
58Axon guidance_Homo sapiens_hsa043600.78190567
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.78024474
60TNF signaling pathway_Homo sapiens_hsa046680.77019184
61Pancreatic cancer_Homo sapiens_hsa052120.75609353
62Rap1 signaling pathway_Homo sapiens_hsa040150.74477103
63MAPK signaling pathway_Homo sapiens_hsa040100.70228593
64Hepatitis B_Homo sapiens_hsa051610.69035821
65Colorectal cancer_Homo sapiens_hsa052100.68454960
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67259674
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65495669
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65425880
69Pathways in cancer_Homo sapiens_hsa052000.65344867
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65324141
71Chemical carcinogenesis_Homo sapiens_hsa052040.65002319
72Pertussis_Homo sapiens_hsa051330.63458367
73Chemokine signaling pathway_Homo sapiens_hsa040620.63317593
74T cell receptor signaling pathway_Homo sapiens_hsa046600.62934352
75Tuberculosis_Homo sapiens_hsa051520.62284443
76Bladder cancer_Homo sapiens_hsa052190.61667017
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59946990
78mTOR signaling pathway_Homo sapiens_hsa041500.57547690
79Platelet activation_Homo sapiens_hsa046110.57026671
80Taste transduction_Homo sapiens_hsa047420.56960520
81Shigellosis_Homo sapiens_hsa051310.56861214
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.56665306
83B cell receptor signaling pathway_Homo sapiens_hsa046620.56595616
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55561539
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54989642
86cAMP signaling pathway_Homo sapiens_hsa040240.54208539
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.52228339
88Mineral absorption_Homo sapiens_hsa049780.52046827
89Hedgehog signaling pathway_Homo sapiens_hsa043400.51207037
90VEGF signaling pathway_Homo sapiens_hsa043700.49896171
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49661641
92Gap junction_Homo sapiens_hsa045400.49310220
93Melanogenesis_Homo sapiens_hsa049160.48046376
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.46131527
95African trypanosomiasis_Homo sapiens_hsa051430.45714972
96MicroRNAs in cancer_Homo sapiens_hsa052060.45486797
97Focal adhesion_Homo sapiens_hsa045100.44351941
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43866302
99PPAR signaling pathway_Homo sapiens_hsa033200.41802855
100Estrogen signaling pathway_Homo sapiens_hsa049150.39856799

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