MUL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.89579993
2Golgi transport vesicle coating (GO:0048200)5.89579993
3L-phenylalanine metabolic process (GO:0006558)5.60736590
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.60736590
5L-phenylalanine catabolic process (GO:0006559)5.40770043
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.40770043
7lysine metabolic process (GO:0006553)4.89763277
8lysine catabolic process (GO:0006554)4.89763277
9NADH metabolic process (GO:0006734)4.83370615
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70550029
11sulfur amino acid catabolic process (GO:0000098)4.66067427
12aromatic amino acid family catabolic process (GO:0009074)4.57989387
13cellular ketone body metabolic process (GO:0046950)4.54166735
14tricarboxylic acid cycle (GO:0006099)4.52186747
15aspartate family amino acid catabolic process (GO:0009068)4.47279510
16kynurenine metabolic process (GO:0070189)4.45704959
17barbed-end actin filament capping (GO:0051016)4.44384396
18protein maturation by protein folding (GO:0022417)4.38098217
19succinate metabolic process (GO:0006105)4.36503040
20oxaloacetate metabolic process (GO:0006107)4.22757422
21amino-acid betaine metabolic process (GO:0006577)4.18616980
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.18570625
23cysteine metabolic process (GO:0006534)4.17211034
24glyoxylate metabolic process (GO:0046487)4.15315133
25regulation of triglyceride catabolic process (GO:0010896)4.05516410
26pinocytosis (GO:0006907)4.05009392
27urea metabolic process (GO:0019627)4.04805217
28urea cycle (GO:0000050)4.04805217
29tryptophan catabolic process (GO:0006569)4.03999417
30indole-containing compound catabolic process (GO:0042436)4.03999417
31indolalkylamine catabolic process (GO:0046218)4.03999417
32serine family amino acid catabolic process (GO:0009071)4.00868197
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.00185697
342-oxoglutarate metabolic process (GO:0006103)3.98818272
35alpha-linolenic acid metabolic process (GO:0036109)3.96765238
36protein localization to endosome (GO:0036010)3.92132242
37bile acid biosynthetic process (GO:0006699)3.90263027
38ketone body metabolic process (GO:1902224)3.86072116
39high-density lipoprotein particle remodeling (GO:0034375)3.82632625
40glycosphingolipid catabolic process (GO:0046479)3.75273179
41alpha-amino acid catabolic process (GO:1901606)3.69436132
42glutamate metabolic process (GO:0006536)3.69222914
43regulation of cholesterol homeostasis (GO:2000188)3.67692129
44nitrogen cycle metabolic process (GO:0071941)3.67081438
45tryptophan metabolic process (GO:0006568)3.66543913
46acetyl-CoA metabolic process (GO:0006084)3.66039467
47glycolipid catabolic process (GO:0019377)3.65213503
48negative regulation of cholesterol transport (GO:0032375)3.63436223
49negative regulation of sterol transport (GO:0032372)3.63436223
50amyloid precursor protein catabolic process (GO:0042987)3.62030200
51short-chain fatty acid metabolic process (GO:0046459)3.61499994
52carnitine metabolic process (GO:0009437)3.58257445
53fatty acid beta-oxidation (GO:0006635)3.57551810
54regulation of cholesterol esterification (GO:0010872)3.56419286
55cellular amino acid catabolic process (GO:0009063)3.55751335
56negative regulation of fibrinolysis (GO:0051918)3.54444565
57fatty acid transmembrane transport (GO:1902001)3.52246183
58pentose-phosphate shunt (GO:0006098)3.51568969
59coenzyme catabolic process (GO:0009109)3.50552768
60homocysteine metabolic process (GO:0050667)3.49076732
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.48002174
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.47605430
63aromatic amino acid family metabolic process (GO:0009072)3.46684614
64drug catabolic process (GO:0042737)3.43597078
65dicarboxylic acid biosynthetic process (GO:0043650)3.43243623
66fatty acid catabolic process (GO:0009062)3.43084272
67triglyceride homeostasis (GO:0070328)3.42865116
68acylglycerol homeostasis (GO:0055090)3.42865116
69flavonoid metabolic process (GO:0009812)3.42085455
70chaperone mediated protein folding requiring cofactor (GO:0051085)3.41730248
71carnitine shuttle (GO:0006853)3.41123149
72fructose metabolic process (GO:0006000)3.40242181
73bile acid metabolic process (GO:0008206)3.38982510
74fatty acid oxidation (GO:0019395)3.38085408
75reverse cholesterol transport (GO:0043691)3.37867574
76dicarboxylic acid catabolic process (GO:0043649)3.36961428
77peptidyl-glutamic acid carboxylation (GO:0017187)3.35767153
78protein carboxylation (GO:0018214)3.35767153
79NAD metabolic process (GO:0019674)3.35497539
80lipid oxidation (GO:0034440)3.33768331
81monocarboxylic acid catabolic process (GO:0072329)3.33658809
82protein retention in ER lumen (GO:0006621)3.32024148
83phospholipid homeostasis (GO:0055091)3.31069291
84protein-lipid complex remodeling (GO:0034368)3.30554543
85macromolecular complex remodeling (GO:0034367)3.30554543
86plasma lipoprotein particle remodeling (GO:0034369)3.30554543
87carboxylic acid catabolic process (GO:0046395)3.27613252
88organic acid catabolic process (GO:0016054)3.27613252
89regulation of fibrinolysis (GO:0051917)3.24966842
90positive regulation of lipid catabolic process (GO:0050996)3.21055977
91NADPH regeneration (GO:0006740)3.20906055
92phospholipid efflux (GO:0033700)3.19060556
93complement activation, alternative pathway (GO:0006957)3.18482998
94cellular modified amino acid catabolic process (GO:0042219)3.17305842
95drug transmembrane transport (GO:0006855)3.15559541
96bile acid and bile salt transport (GO:0015721)3.15250966
97fatty acid homeostasis (GO:0055089)3.14917442
98gluconeogenesis (GO:0006094)3.11979233
99cofactor catabolic process (GO:0051187)3.10858104
100plasma lipoprotein particle clearance (GO:0034381)3.10852902
101regulation of protein activation cascade (GO:2000257)3.09355774
102benzene-containing compound metabolic process (GO:0042537)3.08579618
103carnitine transport (GO:0015879)3.08019298
104amino-acid betaine transport (GO:0015838)3.08019298
105exogenous drug catabolic process (GO:0042738)3.07442136
106heme transport (GO:0015886)3.05177747
107glycine metabolic process (GO:0006544)3.04955699
108lipopolysaccharide biosynthetic process (GO:0009103)3.04593093
109carnitine transmembrane transport (GO:1902603)3.04470176
110endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.04415302
111hexose biosynthetic process (GO:0019319)3.03851962
112peptidyl-arginine omega-N-methylation (GO:0035247)3.03413817
113mitochondrial fusion (GO:0008053)3.02872874
114serine family amino acid metabolic process (GO:0009069)3.01279013
115amino sugar catabolic process (GO:0046348)2.96593731
116positive regulation of fatty acid beta-oxidation (GO:0032000)2.96517026
117pyrimidine nucleoside catabolic process (GO:0046135)2.95479575
118positive regulation of triglyceride lipase activity (GO:0061365)2.95226379
119positive regulation of lipoprotein lipase activity (GO:0051006)2.95226379
120cholesterol efflux (GO:0033344)2.94782190
121arginine metabolic process (GO:0006525)2.94675265
122lipopolysaccharide metabolic process (GO:0008653)2.89921486
123ceramide catabolic process (GO:0046514)2.89376005
124glucose catabolic process (GO:0006007)2.87220037
125cellular response to arsenic-containing substance (GO:0071243)2.87019546
126membrane lipid catabolic process (GO:0046466)2.85893884
127sphingolipid catabolic process (GO:0030149)2.84794310
128negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.82475112
129mitotic nuclear envelope reassembly (GO:0007084)2.78400264
130nuclear envelope reassembly (GO:0031468)2.78400264
131iron-sulfur cluster assembly (GO:0016226)2.77565380
132metallo-sulfur cluster assembly (GO:0031163)2.77565380
133cellular copper ion homeostasis (GO:0006878)2.74238413
134protein deneddylation (GO:0000338)2.71682555
135skin morphogenesis (GO:0043589)2.69078016
136proline biosynthetic process (GO:0006561)2.66360146
137regulation of superoxide anion generation (GO:0032928)2.64797266
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.62913109
139positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61807023
140monosaccharide biosynthetic process (GO:0046364)2.61514967
141membrane protein intracellular domain proteolysis (GO:0031293)2.60767674
142GDP-mannose metabolic process (GO:0019673)2.59995509
143oligosaccharide catabolic process (GO:0009313)2.59623969
144stress fiber assembly (GO:0043149)2.58243018
145glucose 6-phosphate metabolic process (GO:0051156)2.56050374
146spliceosomal tri-snRNP complex assembly (GO:0000244)2.52288364
147histone arginine methylation (GO:0034969)2.51734065
148activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.50746720
149response to peptidoglycan (GO:0032494)2.49680842
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49293014
151protein hydroxylation (GO:0018126)2.48533656
152peptidyl-proline hydroxylation (GO:0019511)2.46664831
153hyaluronan catabolic process (GO:0030214)2.46308022
154serine transport (GO:0032329)2.45849415
155amyloid precursor protein metabolic process (GO:0042982)2.45800520
156glycolytic process (GO:0006096)2.45358205
1574-hydroxyproline metabolic process (GO:0019471)2.43270120
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43182247
159NIK/NF-kappaB signaling (GO:0038061)2.42815362
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41654698
161endoplasmic reticulum unfolded protein response (GO:0030968)2.41588270
162positive regulation of nuclease activity (GO:0032075)2.38861216
163regulation of metalloenzyme activity (GO:0048552)2.37610520
164regulation of membrane protein ectodomain proteolysis (GO:0051043)2.36763020
165response to thyroid hormone (GO:0097066)2.35350577
166positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.35162052
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.33207058
168vesicle coating (GO:0006901)2.32487872
169negative regulation of myeloid cell apoptotic process (GO:0033033)2.32458219
170pyrimidine-containing compound salvage (GO:0008655)2.32359401
171pyrimidine nucleoside salvage (GO:0043097)2.32359401
172cell adhesion mediated by integrin (GO:0033627)2.31216647
173regulation of early endosome to late endosome transport (GO:2000641)2.30931942
174hemidesmosome assembly (GO:0031581)2.30866748
175antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.30402507
176peptidyl-arginine N-methylation (GO:0035246)2.30158751
177peptidyl-arginine methylation (GO:0018216)2.30158751
178heme biosynthetic process (GO:0006783)2.30005018
179membrane protein ectodomain proteolysis (GO:0006509)2.28661409
180tricarboxylic acid metabolic process (GO:0072350)2.28555981
181proteasome assembly (GO:0043248)2.27512865
182cellular response to unfolded protein (GO:0034620)2.27134101
183negative regulation of cell size (GO:0045792)2.26742780
184ER-nucleus signaling pathway (GO:0006984)2.25632690
185* negative regulation of mitochondrion organization (GO:0010823)2.24964840
186negative regulation of nitric oxide biosynthetic process (GO:0045019)2.24671755
187basement membrane organization (GO:0071711)2.24122399
188heme metabolic process (GO:0042168)2.22727932
189positive regulation of chemokine biosynthetic process (GO:0045080)2.20433919
190maintenance of protein localization in organelle (GO:0072595)2.20133944
191cellular response to topologically incorrect protein (GO:0035967)2.19400280
192membrane raft organization (GO:0031579)2.17554800
193response to muramyl dipeptide (GO:0032495)2.16825366
194immunoglobulin mediated immune response (GO:0016064)2.16759432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.34499985
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.82576692
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.38628758
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.35063410
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.54611997
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.32480579
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.77347344
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.20041597
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10868685
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.04686975
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93435835
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67959757
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52069104
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46163123
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.30426490
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26971527
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26809837
18ZNF263_19887448_ChIP-Seq_K562_Human2.19229126
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16141067
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13063740
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11083410
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.07271049
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00280961
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85001704
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83872233
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83680704
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81570308
28TFEB_21752829_ChIP-Seq_HELA_Human1.79106494
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78402341
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76687920
31VDR_21846776_ChIP-Seq_THP-1_Human1.73094878
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72218133
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71832315
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70049250
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63775868
36DCP1A_22483619_ChIP-Seq_HELA_Human1.62995885
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62278494
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62147193
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59931845
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57607805
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.56522367
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54897811
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54649857
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49564653
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45883964
46* ETS1_20019798_ChIP-Seq_JURKAT_Human1.45408636
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43670541
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43505760
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.41254543
50* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41092157
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41022445
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39665852
53* GABP_19822575_ChIP-Seq_HepG2_Human1.39593181
54* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38394652
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.37215142
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36034815
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35742086
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.35439722
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34726959
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34679151
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33086341
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.33037711
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33032806
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32984754
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.32834034
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32092168
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.31684838
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30576523
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27132666
70MYC_22102868_ChIP-Seq_BL_Human1.26496079
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25821894
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25528139
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24584410
74BCOR_27268052_Chip-Seq_Bcells_Human1.24251332
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23268997
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23250240
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23086327
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22653662
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22425327
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.22220046
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21349869
82LXR_22292898_ChIP-Seq_THP-1_Human1.21308336
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20526110
84ATF3_27146783_Chip-Seq_COLON_Human1.20013538
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19855543
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19735644
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19716268
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19538340
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18795707
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18155471
91XRN2_22483619_ChIP-Seq_HELA_Human1.17843215
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17048560
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16845162
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15494868
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15432621
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15359276
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.15004823
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14738781
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14716093
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14658287
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.14101653
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13770849
103* BCL6_27268052_Chip-Seq_Bcells_Human1.13423746
104* MAF_26560356_Chip-Seq_TH1_Human1.12557106
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10194782
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10017565
107* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10009037
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09374118
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08459974
110GABP_17652178_ChIP-ChIP_JURKAT_Human1.08195401
111SPI1_23547873_ChIP-Seq_NB4_Human1.07366908
112FOXA2_19822575_ChIP-Seq_HepG2_Human1.06804606
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06626374
114HNF4A_19822575_ChIP-Seq_HepG2_Human1.06454085
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06418567
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05417208
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05025178
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.04474513
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.04227579
120* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03902579
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03398939
122CTCF_27219007_Chip-Seq_Bcells_Human1.01691254
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01437004
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97805903
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96459199
126* P68_20966046_ChIP-Seq_HELA_Human0.95970275
127* RARA_24833708_ChIP-Seq_LIVER_Mouse0.94807442
128* TAF2_19829295_ChIP-Seq_ESCs_Human0.94680548
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.93419438
130CLOCK_20551151_ChIP-Seq_293T_Human0.92684355
131RARB_27405468_Chip-Seq_BRAIN_Mouse0.90706917
132REST_21632747_ChIP-Seq_MESCs_Mouse0.90655881
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89134016
134HTT_18923047_ChIP-ChIP_STHdh_Human0.87528032
135* RACK7_27058665_Chip-Seq_MCF-7_Human0.86866503
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85754844
137E2F1_20622854_ChIP-Seq_HELA_Human0.85672635
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.84308029
139SMC4_20622854_ChIP-Seq_HELA_Human0.84201892
140* OCT4_20526341_ChIP-Seq_ESCs_Human0.82513016
141* SA1_27219007_Chip-Seq_Bcells_Human0.82496450
142* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82458637
143* KLF4_19829295_ChIP-Seq_ESCs_Human0.82116627
144SOX2_21211035_ChIP-Seq_LN229_Human0.81818866
145TP63_22573176_ChIP-Seq_HFKS_Human0.80445713
146SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78522987
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76790615
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76545131
149EZH2_22144423_ChIP-Seq_EOC_Human0.76488329
150PHF8_20622854_ChIP-Seq_HELA_Human0.76102658
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.75796455
152CTCF_26484167_Chip-Seq_Bcells_Mouse0.75649637
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75379817
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74674707
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74614554
156* FOXH1_21741376_ChIP-Seq_ESCs_Human0.74422932
157CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74244980
158VDR_22108803_ChIP-Seq_LS180_Human0.73869804
159CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73724284
160JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73482353
161* RARB_24833708_ChIP-Seq_LIVER_Mouse0.73089913
162EGR1_19032775_ChIP-ChIP_M12_Human0.72557734
163* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71554226
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.71292053
165* NANOG_20526341_ChIP-Seq_ESCs_Human0.70420779
166CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70409880
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70398273
168* OCT4_19829295_ChIP-Seq_ESCs_Human0.69994634
169EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69853021
170STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.68753274
171ERA_21632823_ChIP-Seq_H3396_Human0.68149691
172CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.67390298
173P53_21459846_ChIP-Seq_SAOS-2_Human0.66619076
174SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66583176
175P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66568203
176TBX20_22328084_ChIP-Seq_HEART_Mouse0.66236052
177TBX20_22080862_ChIP-Seq_HEART_Mouse0.66236052
178SOX2_22085726_ChIP-Seq_NPCs_Mouse0.65857996
179SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.63986040
180TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.63581022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.09219766
2MP0005360_urolithiasis5.66509401
3MP0005085_abnormal_gallbladder_physiolo4.83026415
4MP0008875_abnormal_xenobiotic_pharmacok4.17103450
5MP0005365_abnormal_bile_salt4.13688720
6MP0003806_abnormal_nucleotide_metabolis3.44482784
7MP0008260_abnormal_autophagy3.41221326
8MP0009840_abnormal_foam_cell3.33842377
9MP0002837_dystrophic_cardiac_calcinosis3.29676656
10MP0010329_abnormal_lipoprotein_level2.88726980
11MP0003646_muscle_fatigue2.88044815
12MP0005332_abnormal_amino_acid2.61052576
13MP0002822_catalepsy2.45713002
14MP0005083_abnormal_biliary_tract2.41117892
15MP0003195_calcinosis2.32293839
16MP0003191_abnormal_cellular_cholesterol2.27284203
17MP0003252_abnormal_bile_duct2.25622313
18MP0008438_abnormal_cutaneous_collagen2.22418846
19MP0003436_decreased_susceptibility_to2.15969647
20MP0001666_abnormal_nutrient_absorption2.14528699
21MP0002877_abnormal_melanocyte_morpholog2.13961837
22MP0006036_abnormal_mitochondrial_physio2.07166684
23MP0000343_altered_response_to1.98973706
24MP0004130_abnormal_muscle_cell1.91504431
25MP0003075_altered_response_to1.89194719
26MP0002118_abnormal_lipid_homeostasis1.87169879
27MP0004019_abnormal_vitamin_homeostasis1.86251103
28MP0005257_abnormal_intraocular_pressure1.86028934
29MP0003172_abnormal_lysosome_physiology1.73184118
30MP0005319_abnormal_enzyme/_coenzyme1.71803455
31MP0000750_abnormal_muscle_regeneration1.71759044
32MP0005670_abnormal_white_adipose1.70392697
33MP0004043_abnormal_pH_regulation1.67935757
34MP0003566_abnormal_cell_adhesion1.67743585
35MP0006082_CNS_inflammation1.65822309
36MP0000858_altered_metastatic_potential1.65714279
37MP0003828_pulmonary_edema1.63780417
38MP0000609_abnormal_liver_physiology1.61323051
39MP0003724_increased_susceptibility_to1.60249776
40MP0005584_abnormal_enzyme/coenzyme_acti1.59705903
41MP0003303_peritoneal_inflammation1.58099426
42MP0006035_abnormal_mitochondrial_morpho1.57461389
43MP0000751_myopathy1.55291838
44MP0004272_abnormal_basement_membrane1.53326825
45MP0005410_abnormal_fertilization1.52456369
46MP0004036_abnormal_muscle_relaxation1.52324398
47MP0003329_amyloid_beta_deposits1.52208819
48MP0005165_increased_susceptibility_to1.51961606
49MP0003221_abnormal_cardiomyocyte_apopto1.47584532
50MP0004084_abnormal_cardiac_muscle1.45338172
51MP0002419_abnormal_innate_immunity1.44262335
52MP0001542_abnormal_bone_strength1.43502983
53MP0009785_altered_susceptibility_to1.43414789
54MP0002148_abnormal_hypersensitivity_rea1.43370576
55MP0005330_cardiomyopathy1.39970264
56MP0005464_abnormal_platelet_physiology1.39194217
57MP0009278_abnormal_bone_marrow1.37835215
58MP0004510_myositis1.36128788
59MP0001764_abnormal_homeostasis1.31790921
60MP0001849_ear_inflammation1.31736534
61MP0003656_abnormal_erythrocyte_physiolo1.31569456
62MP0009643_abnormal_urine_homeostasis1.30904188
63MP0001545_abnormal_hematopoietic_system1.28710547
64MP0005397_hematopoietic_system_phenotyp1.28710547
65MP0004215_abnormal_myocardial_fiber1.28372446
66MP0003300_gastrointestinal_ulcer1.27476884
67MP0000604_amyloidosis1.25437146
68MP0001533_abnormal_skeleton_physiology1.24740537
69MP0002060_abnormal_skin_morphology1.23278078
70MP0002269_muscular_atrophy1.22900871
71MP0000749_muscle_degeneration1.22557013
72MP0009333_abnormal_splenocyte_physiolog1.22464922
73MP0005000_abnormal_immune_tolerance1.20321035
74MP0005025_abnormal_response_to1.19941854
75MP0003283_abnormal_digestive_organ1.19105416
76MP0005535_abnormal_body_temperature1.18552947
77MP0003448_altered_tumor_morphology1.18014869
78MP0000465_gastrointestinal_hemorrhage1.16112962
79MP0000759_abnormal_skeletal_muscle1.15427382
80MP0005636_abnormal_mineral_homeostasis1.15402371
81MP0005451_abnormal_body_composition1.13742444
82MP0006054_spinal_hemorrhage1.12304716
83MP0003453_abnormal_keratinocyte_physiol1.10768349
84MP0004947_skin_inflammation1.10561473
85MP0005023_abnormal_wound_healing1.10361628
86MP0010234_abnormal_vibrissa_follicle1.08107878
87MP0005166_decreased_susceptibility_to1.07781407
88MP0004859_abnormal_synaptic_plasticity1.07345017
89MP0005266_abnormal_metabolism1.05897827
90MP0009046_muscle_twitch1.03016185
91MP0002332_abnormal_exercise_endurance1.02739672
92MP0002909_abnormal_adrenal_gland1.02575936
93MP0008469_abnormal_protein_level1.02286363
94MP0001756_abnormal_urination1.01573285
95MP0002078_abnormal_glucose_homeostasis1.00647229
96MP0008007_abnormal_cellular_replicative1.00144628
97MP0009764_decreased_sensitivity_to0.99834902
98MP0001243_abnormal_dermal_layer0.99547085
99MP0001853_heart_inflammation0.99332080
100MP0002971_abnormal_brown_adipose0.97062565
101MP0001915_intracranial_hemorrhage0.97013299
102MP0003186_abnormal_redox_activity0.96815915
103MP0005666_abnormal_adipose_tissue0.96507044
104MP0002736_abnormal_nociception_after0.94427532
105MP0001765_abnormal_ion_homeostasis0.94334400
106MP0004147_increased_porphyrin_level0.93771846
107MP0002876_abnormal_thyroid_physiology0.92864065
108MP0001845_abnormal_inflammatory_respons0.92757227
109MP0002723_abnormal_immune_serum0.92099043
110MP0002998_abnormal_bone_remodeling0.92027627
111MP0003111_abnormal_nucleus_morphology0.90613331
112MP0002452_abnormal_antigen_presenting0.90345725
113MP0003091_abnormal_cell_migration0.90246568
114MP0005387_immune_system_phenotype0.89758681
115MP0001790_abnormal_immune_system0.89758681
116MP0003950_abnormal_plasma_membrane0.89550691
117MP0000358_abnormal_cell_content/0.89166687
118MP0003879_abnormal_hair_cell0.88039255
119MP0005501_abnormal_skin_physiology0.86921805
120MP0004087_abnormal_muscle_fiber0.86557996
121MP0009763_increased_sensitivity_to0.86557342
122MP0005448_abnormal_energy_balance0.85691248
123MP0001440_abnormal_grooming_behavior0.85135611
124MP0005620_abnormal_muscle_contractility0.83340749
125MP0001661_extended_life_span0.82418925
126MP0002972_abnormal_cardiac_muscle0.82339597
127MP0009780_abnormal_chondrocyte_physiolo0.82030744
128MP0003868_abnormal_feces_composition0.81820704
129MP0008961_abnormal_basal_metabolism0.81534960
130MP0005621_abnormal_cell_physiology0.81158753
131MP0004484_altered_response_of0.81096995
132MP0000747_muscle_weakness0.80936402
133MP0008872_abnormal_physiological_respon0.80841019
134MP0008789_abnormal_olfactory_epithelium0.80482411
135MP0003279_aneurysm0.80366793
136MP0002064_seizures0.80179931
137MP0005623_abnormal_meninges_morphology0.79820746
138MP0005164_abnormal_response_to0.79517291
139MP0000003_abnormal_adipose_tissue0.79493885
140MP0009745_abnormal_behavioral_response0.76824685
141MP0005376_homeostasis/metabolism_phenot0.76795518
142MP0010030_abnormal_orbit_morphology0.76289039
143MP0008874_decreased_physiological_sensi0.75937337
144MP0005058_abnormal_lysosome_morphology0.75706433
145MP0009642_abnormal_blood_homeostasis0.75438218
146MP0005390_skeleton_phenotype0.75035320
147MP0001501_abnormal_sleep_pattern0.74454316
148MP0004270_analgesia0.74293633
149MP0002106_abnormal_muscle_physiology0.73583678
150MP0001968_abnormal_touch/_nociception0.72920566
151MP0004233_abnormal_muscle_weight0.72743746
152MP0003705_abnormal_hypodermis_morpholog0.71864904
153MP0001819_abnormal_immune_cell0.71573343
154MP0002138_abnormal_hepatobiliary_system0.71287759
155MP0003635_abnormal_synaptic_transmissio0.70560918
156MP0002420_abnormal_adaptive_immunity0.70492371
157MP0001216_abnormal_epidermal_layer0.70451032
158MP0000685_abnormal_immune_system0.69939011
159MP0002405_respiratory_system_inflammati0.69088641
160MP0003137_abnormal_impulse_conducting0.68362753
161MP0003795_abnormal_bone_structure0.68277338
162MP0003011_delayed_dark_adaptation0.68196790
163MP0005385_cardiovascular_system_phenoty0.68024214
164MP0001544_abnormal_cardiovascular_syste0.68024214
165MP0000598_abnormal_liver_morphology0.67964923
166MP0006138_congestive_heart_failure0.66038854
167MP0004085_abnormal_heartbeat0.64012518
168MP0000230_abnormal_systemic_arterial0.63949987
169MP0009697_abnormal_copulation0.61753828
170MP0004142_abnormal_muscle_tone0.61504993
171MP0005334_abnormal_fat_pad0.60044445
172MP0003953_abnormal_hormone_level0.59962406
173MP0005167_abnormal_blood-brain_barrier0.59235857
174MP0008775_abnormal_heart_ventricle0.56772676
175MP0005647_abnormal_sex_gland0.55773948
176MP0002063_abnormal_learning/memory/cond0.54497393

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.10224789
2Abnormality of glycolipid metabolism (HP:0010969)4.76393487
3Abnormality of liposaccharide metabolism (HP:0010968)4.76393487
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.76393487
5Xanthomatosis (HP:0000991)4.34755198
6Deep venous thrombosis (HP:0002625)4.17401549
7Intrahepatic cholestasis (HP:0001406)4.14407962
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.07231267
9Hyperammonemia (HP:0001987)3.98436946
10Hyperglycinuria (HP:0003108)3.94942166
11Vertebral compression fractures (HP:0002953)3.92567221
12Hyperglycinemia (HP:0002154)3.88731533
13Hypobetalipoproteinemia (HP:0003563)3.85394768
14Ketosis (HP:0001946)3.79185892
15Hyperlipoproteinemia (HP:0010980)3.78913220
16Abnormality of glycine metabolism (HP:0010895)3.59101203
17Abnormality of serine family amino acid metabolism (HP:0010894)3.59101203
18Loss of speech (HP:0002371)3.52279242
19Cerebral edema (HP:0002181)3.37359748
20Vacuolated lymphocytes (HP:0001922)3.36868919
21Gout (HP:0001997)3.33363994
22Prolonged partial thromboplastin time (HP:0003645)3.26714765
23Distal lower limb muscle weakness (HP:0009053)3.18877764
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.18244222
25Dicarboxylic aciduria (HP:0003215)3.18244222
26Centrally nucleated skeletal muscle fibers (HP:0003687)3.16211670
27Ketoacidosis (HP:0001993)3.11902883
28Hypolipoproteinemia (HP:0010981)3.11521632
29Acute encephalopathy (HP:0006846)3.10105063
30Hepatic necrosis (HP:0002605)3.09318035
31Lethargy (HP:0001254)3.07655580
32Abnormality of fatty-acid metabolism (HP:0004359)3.06891571
33Premature rupture of membranes (HP:0001788)3.06261155
34Abnormal gallbladder physiology (HP:0012438)3.05701979
35Cholecystitis (HP:0001082)3.05701979
36Exercise-induced myalgia (HP:0003738)3.02039316
37Hypoglycemic coma (HP:0001325)2.99398911
38Myoglobinuria (HP:0002913)2.96404768
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96132308
40Increased connective tissue (HP:0009025)2.95993639
41Axonal loss (HP:0003447)2.95734655
42Hypoalphalipoproteinemia (HP:0003233)2.91210662
43Abnormal mitochondria in muscle tissue (HP:0008316)2.83707009
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.82179928
45Hepatocellular necrosis (HP:0001404)2.80578309
46Cholelithiasis (HP:0001081)2.80491434
47Sudden death (HP:0001699)2.76896342
48Complement deficiency (HP:0004431)2.76251514
49Increased cerebral lipofuscin (HP:0011813)2.74191644
50Nemaline bodies (HP:0003798)2.72651448
51Dysostosis multiplex (HP:0000943)2.71215095
52Difficulty climbing stairs (HP:0003551)2.70270511
53Abnormal gallbladder morphology (HP:0012437)2.69810552
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.67919679
55Increased muscle lipid content (HP:0009058)2.66561095
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66144717
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64845737
58Distal upper limb amyotrophy (HP:0007149)2.64117259
59Upper limb amyotrophy (HP:0009129)2.64117259
60Metabolic acidosis (HP:0001942)2.61434859
61Acute necrotizing encephalopathy (HP:0006965)2.60912429
62Hyperventilation (HP:0002883)2.59059400
63Distal lower limb amyotrophy (HP:0008944)2.58034042
64Muscle fiber inclusion bodies (HP:0100299)2.57697772
65Achilles tendon contracture (HP:0001771)2.57467115
66Prolonged neonatal jaundice (HP:0006579)2.57400678
67Abnormality of serum amino acid levels (HP:0003112)2.56899624
68Hypokinesia (HP:0002375)2.54682286
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53998958
70Pheochromocytoma (HP:0002666)2.49861144
71Hand muscle atrophy (HP:0009130)2.49485078
72Mitochondrial inheritance (HP:0001427)2.48614999
73Hypercholesterolemia (HP:0003124)2.46929585
74Lactic acidosis (HP:0003128)2.44956502
75Exercise-induced muscle cramps (HP:0003710)2.42095106
76Systemic lupus erythematosus (HP:0002725)2.41695120
77Increased CSF lactate (HP:0002490)2.40891388
78Rhabdomyolysis (HP:0003201)2.40086101
79Abnormality of purine metabolism (HP:0004352)2.39003469
80Abnormality of macrophages (HP:0004311)2.37726018
81Abnormality of skeletal muscle fiber size (HP:0012084)2.37425537
82Abnormality of methionine metabolism (HP:0010901)2.37247376
83Epidermoid cyst (HP:0200040)2.37236626
84Progressive neurologic deterioration (HP:0002344)2.36828608
85Neuroendocrine neoplasm (HP:0100634)2.36508947
86Increased intramyocellular lipid droplets (HP:0012240)2.34961769
87Vomiting (HP:0002013)2.32401203
88Limb-girdle muscle atrophy (HP:0003797)2.29753665
89Abnormality of the Achilles tendon (HP:0005109)2.29415927
90Spinal rigidity (HP:0003306)2.29089635
91Ragged-red muscle fibers (HP:0003200)2.27991844
92Fat malabsorption (HP:0002630)2.27150240
93Neck muscle weakness (HP:0000467)2.26630552
94Progressive muscle weakness (HP:0003323)2.24728966
95Palpitations (HP:0001962)2.24443291
96Abnormality of glycolysis (HP:0004366)2.23569336
97Increased serum pyruvate (HP:0003542)2.23569336
98Amyloidosis (HP:0011034)2.22254939
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21281913
100Abnormality of polysaccharide metabolism (HP:0011012)2.21281913
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21281913
102Abnormal cartilage morphology (HP:0002763)2.21269800
103Hyperbilirubinemia (HP:0002904)2.20775008
104CNS demyelination (HP:0007305)2.20147112
105Hepatosplenomegaly (HP:0001433)2.18075005
106Petechiae (HP:0000967)2.17756584
107Generalized amyotrophy (HP:0003700)2.17587495
108Myopathic facies (HP:0002058)2.17374142
109Irritability (HP:0000737)2.17143364
110Apathy (HP:0000741)2.16586515
111Late onset (HP:0003584)2.16477092
112Abnormality of the distal phalanges of the toes (HP:0010182)2.16097119
113Joint hemorrhage (HP:0005261)2.15949318
114Shoulder girdle muscle weakness (HP:0003547)2.14307381
115Fatigue (HP:0012378)2.14097027
116Reduced subcutaneous adipose tissue (HP:0003758)2.13788517
117Methylmalonic aciduria (HP:0012120)2.12562622
118Abnormality of the gallbladder (HP:0005264)2.11562419
119Increased neuronal autofluorescent lipopigment (HP:0002074)2.11516518
120Abnormality of nucleobase metabolism (HP:0010932)2.11308740
121Rough bone trabeculation (HP:0100670)2.11125593
122Focal motor seizures (HP:0011153)2.08715955
123Increased variability in muscle fiber diameter (HP:0003557)2.08713732
124Progressive macrocephaly (HP:0004481)2.05452823
125Urinary glycosaminoglycan excretion (HP:0003541)2.05067716
126Mucopolysacchariduria (HP:0008155)2.05067716
127Diminished motivation (HP:0000745)2.04546137
128Increased purine levels (HP:0004368)2.03920784
129Hyperuricemia (HP:0002149)2.03920784
130Supranuclear gaze palsy (HP:0000605)2.03239846
131Upper motor neuron abnormality (HP:0002127)2.02991905
132Type 1 muscle fiber predominance (HP:0003803)2.02650169
133Glycosuria (HP:0003076)2.02537788
134Abnormality of urine glucose concentration (HP:0011016)2.02537788
135Skin nodule (HP:0200036)2.01905918
136EMG: myopathic abnormalities (HP:0003458)2.01620187
137Status epilepticus (HP:0002133)2.00721776
138Oligomenorrhea (HP:0000876)2.00499041
139Right ventricular cardiomyopathy (HP:0011663)2.00239696
140Asymmetric septal hypertrophy (HP:0001670)2.00232802
141Bulbar palsy (HP:0001283)1.99777754
142Respiratory failure (HP:0002878)1.99235321
143Abnormality of complement system (HP:0005339)1.98742742
144Spontaneous abortion (HP:0005268)1.98740688
145Malnutrition (HP:0004395)1.98351109
146Proximal tubulopathy (HP:0000114)1.98210584
147Muscle fiber splitting (HP:0003555)1.98171698
148Sensorimotor neuropathy (HP:0007141)1.97257814
149Hyporeflexia of lower limbs (HP:0002600)1.96669462
150Ventricular tachycardia (HP:0004756)1.96413981
151Abnormality of the common coagulation pathway (HP:0010990)1.95225499
152Abnormality of the intrinsic pathway (HP:0010989)1.94857909
153Atrioventricular block (HP:0001678)1.94350555
154Delayed CNS myelination (HP:0002188)1.93420080
155Atrophic scars (HP:0001075)1.91082308
156Neonatal onset (HP:0003623)1.90956131
157Ventricular fibrillation (HP:0001663)1.90498665
158Abnormality of the lower motor neuron (HP:0002366)1.88774855
159Interstitial pulmonary disease (HP:0006530)1.88370061
160Trismus (HP:0000211)1.88313688
161Entropion (HP:0000621)1.87532502
162Abnormal protein N-linked glycosylation (HP:0012347)1.86294783
163Abnormal protein glycosylation (HP:0012346)1.86294783
164Abnormal glycosylation (HP:0012345)1.86294783
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86294783
166Neoplasm of head and neck (HP:0012288)1.85056837
167Esophageal neoplasm (HP:0100751)1.85056837
168Recurrent abscess formation (HP:0002722)1.82755887
169Purpura (HP:0000979)1.81458902
170Neuronal loss in central nervous system (HP:0002529)1.81441127
171Short nail (HP:0001799)1.80630583
172Type I transferrin isoform profile (HP:0003642)1.80331965
173Reduced antithrombin III activity (HP:0001976)1.78934549
174Fasciculations (HP:0002380)1.78285315
175Protrusio acetabuli (HP:0003179)1.77654447
176Muscle fibrillation (HP:0010546)1.77192781
177Abnormality of the umbilical cord (HP:0010881)1.76870238
178Pelvic girdle muscle weakness (HP:0003749)1.76791714
179Neurofibrillary tangles (HP:0002185)1.74966537
180Tongue fasciculations (HP:0001308)1.74955406
181Myocardial infarction (HP:0001658)1.72720664
182Growth hormone excess (HP:0000845)1.72202527
183Mildly elevated creatine phosphokinase (HP:0008180)1.70350664
184Hypertensive crisis (HP:0100735)1.69787594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.17292521
2PDK45.17292521
3TAOK35.12365690
4BCKDK4.25400449
5NME24.04714926
6TESK23.47551503
7IRAK33.15459485
8PDK23.08033671
9TRIB32.61095481
10PIM22.60001709
11TAOK22.55164955
12LIMK12.47601871
13ARAF2.46189108
14TBK12.36518180
15MAP2K41.87820403
16PKN21.85201230
17NEK11.81326594
18MAP3K91.81182545
19RIPK11.78064492
20PAK41.75043807
21PINK11.71418481
22DAPK21.69340700
23LMTK21.58653797
24SIK31.57718327
25MST1R1.50033125
26BUB11.49696502
27AKT31.42902587
28STK161.40596890
29TTN1.38191662
30PHKG11.35982453
31PHKG21.35982453
32PBK1.35765054
33MAP3K141.33179817
34SIK11.30372140
35MYLK1.30144035
36SCYL21.29871445
37EPHA41.29107600
38SMG11.28779004
39EPHB11.27925395
40VRK21.25890191
41EPHB21.25257606
42MAP3K41.24607575
43BRAF1.22291610
44KSR21.20588782
45OBSCN1.20125281
46ERBB41.17935229
47NME11.17868766
48MAP2K21.17551908
49FGFR41.13268807
50KDR1.13110681
51WNK41.13051304
52STK101.12093574
53TGFBR21.11609106
54GRK61.11398846
55ERN11.09493441
56DDR21.09197237
57MOS1.09155959
58MAP3K71.08980908
59MUSK1.07221533
60PTK2B1.06553382
61DAPK31.05567289
62GRK51.04888368
63MAP3K111.02981996
64MAP3K20.97544675
65ICK0.97394931
66TRIM280.97121639
67TAOK10.96898775
68CAMK2G0.95121348
69MAPKAPK30.90099116
70MAP3K120.86730816
71PDPK10.84630501
72CASK0.84311814
73STK380.83873675
74MAP3K80.82879542
75PDK10.81982810
76GRK70.81358910
77MATK0.80748536
78TYK20.80508858
79IKBKB0.80295054
80PRKG20.77393571
81MAP3K10.77287967
82RAF10.77101625
83IKBKE0.76732041
84DAPK10.74988983
85SGK2230.74320619
86SGK4940.74320619
87DYRK1B0.73453005
88EIF2AK10.73270068
89PTK20.73081214
90PRKD30.72524502
91TSSK60.71552266
92MAP2K60.70244842
93ZAP700.68648479
94CSNK1G30.68593579
95NTRK30.67012686
96ABL20.66200378
97MAPK120.65441610
98IRAK40.65012312
99MAP2K10.64287065
100PAK10.63478713
101CAMKK10.63426006
102MAP2K70.63089601
103PAK60.61404286
104MAPK110.61350389
105PRKD20.60189222
106CSK0.60124553
107PRKCG0.59264270
108CAMK2D0.58169321
109PRKAA10.57554980
110PRKAA20.57185597
111EPHA20.56954347
112CAMK2A0.56180401
113MAP3K130.55464941
114RPS6KA20.54212017
115CDC42BPA0.53550642
116RIPK40.53543808
117AKT20.53170127
118SGK30.52639371
119PIK3CA0.51955575
120PRKACG0.51077209
121PTK60.50273368
122TESK10.49842500
123MAPKAPK20.48825059
124MAP3K30.48655371
125AURKA0.48189924
126FGR0.47532645
127CAMK40.46864263
128TXK0.45251872
129CSNK1A1L0.45167350
130RPS6KC10.45070901
131RPS6KL10.45070901
132JAK30.44522718
133LATS20.43978026
134EIF2AK30.42427532
135BMX0.41212534
136JAK20.40465239
137OXSR10.40201612
138SGK20.39341278
139PRKCZ0.39132587
140BLK0.38536448
141CCNB10.38491948
142NTRK10.38309264
143CAMK2B0.38189000
144GSK3A0.38155403
145INSRR0.36657740
146STK110.35985369
147IRAK20.35597021
148ROCK20.34263189
149MINK10.33886724
150CDK140.32166639
151PDGFRA0.32109350
152DYRK30.31320950
153CDK50.31307366
154MAPK40.31290941
155FER0.30348223
156ILK0.29784350
157NEK90.29744433
158MAP2K30.29327915
159CDK190.27996609
160PRPF4B0.27385830
161MAP3K50.27222899
162PRKACA0.26955079

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.00929846
2Other glycan degradation_Homo sapiens_hsa005113.60263770
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.10977423
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.96815204
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.85344705
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81577821
7Propanoate metabolism_Homo sapiens_hsa006402.60282852
8Arginine biosynthesis_Homo sapiens_hsa002202.58960094
9Lysosome_Homo sapiens_hsa041422.50493897
10Fatty acid degradation_Homo sapiens_hsa000712.48719142
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.44102765
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.34934019
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33658874
14Proteasome_Homo sapiens_hsa030502.33474404
15Nitrogen metabolism_Homo sapiens_hsa009102.33327249
16Butanoate metabolism_Homo sapiens_hsa006502.32881948
17Pyruvate metabolism_Homo sapiens_hsa006202.26416327
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07818490
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.05145035
20Tryptophan metabolism_Homo sapiens_hsa003802.04141688
21Carbon metabolism_Homo sapiens_hsa012001.96310479
22Fatty acid metabolism_Homo sapiens_hsa012121.95698296
23PPAR signaling pathway_Homo sapiens_hsa033201.76697045
24Sulfur metabolism_Homo sapiens_hsa009201.75807000
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74140304
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68560261
27Oxidative phosphorylation_Homo sapiens_hsa001901.65869802
28Peroxisome_Homo sapiens_hsa041461.64121885
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59549288
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.53605045
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53468691
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53000125
33Biosynthesis of amino acids_Homo sapiens_hsa012301.52734316
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51638539
35Bile secretion_Homo sapiens_hsa049761.51410956
36Shigellosis_Homo sapiens_hsa051311.50494727
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48893653
38beta-Alanine metabolism_Homo sapiens_hsa004101.45607927
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44925878
40Legionellosis_Homo sapiens_hsa051341.44031558
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41778166
42Phenylalanine metabolism_Homo sapiens_hsa003601.39532284
43Complement and coagulation cascades_Homo sapiens_hsa046101.38169432
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37461324
45Parkinsons disease_Homo sapiens_hsa050121.36002257
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31667206
47Fatty acid elongation_Homo sapiens_hsa000621.30114414
48Vitamin B6 metabolism_Homo sapiens_hsa007501.28343661
49N-Glycan biosynthesis_Homo sapiens_hsa005101.28340527
50Chemical carcinogenesis_Homo sapiens_hsa052041.26545513
51Sulfur relay system_Homo sapiens_hsa041221.26448897
52Salmonella infection_Homo sapiens_hsa051321.26105995
53Bladder cancer_Homo sapiens_hsa052191.24649464
54Folate biosynthesis_Homo sapiens_hsa007901.23005767
55Fat digestion and absorption_Homo sapiens_hsa049751.22174094
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18431128
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.18108664
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17767519
59Fructose and mannose metabolism_Homo sapiens_hsa000511.14358983
60Pertussis_Homo sapiens_hsa051331.11943953
61Histidine metabolism_Homo sapiens_hsa003401.11891691
62Osteoclast differentiation_Homo sapiens_hsa043801.11777613
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11638239
64Phagosome_Homo sapiens_hsa041451.10490744
65Sphingolipid metabolism_Homo sapiens_hsa006001.09781955
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08649897
67Starch and sucrose metabolism_Homo sapiens_hsa005001.08115513
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07703393
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07326628
70Base excision repair_Homo sapiens_hsa034101.06453196
71Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06343906
72Selenocompound metabolism_Homo sapiens_hsa004501.04948220
73Rheumatoid arthritis_Homo sapiens_hsa053231.03085263
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01867348
75Apoptosis_Homo sapiens_hsa042101.01130180
76Alzheimers disease_Homo sapiens_hsa050100.99333671
77Cardiac muscle contraction_Homo sapiens_hsa042600.97500851
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.96184663
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94576417
80Viral myocarditis_Homo sapiens_hsa054160.92247496
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92118250
82Pentose phosphate pathway_Homo sapiens_hsa000300.92058727
83Glycerolipid metabolism_Homo sapiens_hsa005610.91391299
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90206491
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89504013
86Retinol metabolism_Homo sapiens_hsa008300.89362694
87Tyrosine metabolism_Homo sapiens_hsa003500.88930726
88Leishmaniasis_Homo sapiens_hsa051400.86868300
89Huntingtons disease_Homo sapiens_hsa050160.84129804
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84010825
91Arginine and proline metabolism_Homo sapiens_hsa003300.80927978
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80819684
93Tuberculosis_Homo sapiens_hsa051520.80283631
94Caffeine metabolism_Homo sapiens_hsa002320.79923397
95Collecting duct acid secretion_Homo sapiens_hsa049660.79419657
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.78417882
97Endocytosis_Homo sapiens_hsa041440.77200162
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77069955
99Fatty acid biosynthesis_Homo sapiens_hsa000610.74620021
100ABC transporters_Homo sapiens_hsa020100.74458748
101Malaria_Homo sapiens_hsa051440.73898197
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.72524827
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70745319
104Herpes simplex infection_Homo sapiens_hsa051680.70267904
105Galactose metabolism_Homo sapiens_hsa000520.69442867
106Influenza A_Homo sapiens_hsa051640.69068963
107Hepatitis B_Homo sapiens_hsa051610.68972234
108Synaptic vesicle cycle_Homo sapiens_hsa047210.66502354
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66120657
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62430557
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.62354832
112Epstein-Barr virus infection_Homo sapiens_hsa051690.60849823
113Staphylococcus aureus infection_Homo sapiens_hsa051500.59173597
114TNF signaling pathway_Homo sapiens_hsa046680.58147913
115Steroid biosynthesis_Homo sapiens_hsa001000.58020205
116Toxoplasmosis_Homo sapiens_hsa051450.57000386
117DNA replication_Homo sapiens_hsa030300.56955412
118Metabolic pathways_Homo sapiens_hsa011000.56196536
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.55994262
120Pyrimidine metabolism_Homo sapiens_hsa002400.55926944
121Hepatitis C_Homo sapiens_hsa051600.55370736
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55204116
123Glucagon signaling pathway_Homo sapiens_hsa049220.54768497
124p53 signaling pathway_Homo sapiens_hsa041150.54716127
125Glutathione metabolism_Homo sapiens_hsa004800.53236760
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.52997653
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49058491
128Acute myeloid leukemia_Homo sapiens_hsa052210.46184085
129Measles_Homo sapiens_hsa051620.46120169
130Vitamin digestion and absorption_Homo sapiens_hsa049770.46064631
131Amoebiasis_Homo sapiens_hsa051460.45758376
132Antigen processing and presentation_Homo sapiens_hsa046120.44771335
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43724290
134Chronic myeloid leukemia_Homo sapiens_hsa052200.43544182
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39836506
136Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38978764
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.38136052
138Small cell lung cancer_Homo sapiens_hsa052220.36437092
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36340089
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33380707
141Spliceosome_Homo sapiens_hsa030400.32962007
142Pancreatic cancer_Homo sapiens_hsa052120.32864262
143Viral carcinogenesis_Homo sapiens_hsa052030.32472976
144Insulin resistance_Homo sapiens_hsa049310.31567153
145Prion diseases_Homo sapiens_hsa050200.26807043
146Insulin signaling pathway_Homo sapiens_hsa049100.26629412
147Lysine degradation_Homo sapiens_hsa003100.23934949
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23550782
149Mineral absorption_Homo sapiens_hsa049780.22271574
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21921323
151GABAergic synapse_Homo sapiens_hsa047270.21295816
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20775004
153AMPK signaling pathway_Homo sapiens_hsa041520.20207958
154Regulation of autophagy_Homo sapiens_hsa041400.19614241
155Insulin secretion_Homo sapiens_hsa049110.15709531
156Vibrio cholerae infection_Homo sapiens_hsa051100.15352675
157Salivary secretion_Homo sapiens_hsa049700.15207480
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13811140
159Type II diabetes mellitus_Homo sapiens_hsa049300.13159603
160Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12665558
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.10218139
162Linoleic acid metabolism_Homo sapiens_hsa005910.07259227
163Dilated cardiomyopathy_Homo sapiens_hsa054140.05686475
164Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05408150

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