MUM1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a mutated melanoma-associated antigen 1 domain. Proteins which contain mutated antigens are expressed at high levels on certain types of cancers. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.16738725
2muscle filament sliding (GO:0030049)6.16738725
3piRNA metabolic process (GO:0034587)6.05963570
4synaptonemal complex organization (GO:0070193)5.86209244
5synaptonemal complex assembly (GO:0007130)5.85245932
6regulation of meiosis I (GO:0060631)5.61641965
7cardiac muscle hypertrophy (GO:0003300)5.51529028
8regulation of relaxation of muscle (GO:1901077)5.41301836
9positive regulation of male gonad development (GO:2000020)5.35438067
10actin-mediated cell contraction (GO:0070252)5.26627645
11sarcoplasmic reticulum calcium ion transport (GO:0070296)5.22235816
12striated muscle hypertrophy (GO:0014897)5.20358075
13myofibril assembly (GO:0030239)5.03998335
14regulation of male gonad development (GO:2000018)5.02853716
15male meiosis (GO:0007140)4.94348969
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.87750970
17sarcomere organization (GO:0045214)4.84376230
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.73619435
19muscle hypertrophy (GO:0014896)4.56399528
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.56048105
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.51302632
22sex determination (GO:0007530)4.43674442
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.42908868
24DNA methylation involved in gamete generation (GO:0043046)4.42629412
25muscle hypertrophy in response to stress (GO:0003299)4.31716607
26cardiac muscle adaptation (GO:0014887)4.31716607
27cardiac muscle hypertrophy in response to stress (GO:0014898)4.31716607
28gonadal mesoderm development (GO:0007506)4.28312989
29relaxation of cardiac muscle (GO:0055119)4.23342777
30striated muscle contraction (GO:0006941)4.18611816
31cardiac muscle contraction (GO:0060048)4.12145599
32regulation of skeletal muscle contraction (GO:0014819)4.09925052
33cell communication by electrical coupling (GO:0010644)4.09839268
34regulation of actin filament-based movement (GO:1903115)4.04393158
35fusion of sperm to egg plasma membrane (GO:0007342)4.03585096
36COPI coating of Golgi vesicle (GO:0048205)3.94239673
37Golgi transport vesicle coating (GO:0048200)3.94239673
38actin filament-based movement (GO:0030048)3.87586327
39sex differentiation (GO:0007548)3.86749956
40cardiac muscle cell development (GO:0055013)3.86484450
41nuclear pore complex assembly (GO:0051292)3.73493842
42cell communication involved in cardiac conduction (GO:0086065)3.71323191
43positive regulation of meiosis (GO:0045836)3.68345776
44chromosome organization involved in meiosis (GO:0070192)3.66859405
45response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.63376012
46regulation of the force of heart contraction (GO:0002026)3.63374849
47skeletal muscle contraction (GO:0003009)3.62533326
48response to inactivity (GO:0014854)3.61909538
49relaxation of muscle (GO:0090075)3.58226905
50cardiac cell development (GO:0055006)3.55613091
51nuclear pore organization (GO:0006999)3.53877418
52actomyosin structure organization (GO:0031032)3.52945006
53regulation of cell communication by electrical coupling (GO:0010649)3.48738984
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.45545260
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39683676
56oocyte development (GO:0048599)3.38622919
57negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36941798
58meiotic nuclear division (GO:0007126)3.36413236
59adult heart development (GO:0007512)3.33571298
60positive regulation of meiotic cell cycle (GO:0051446)3.32935136
61embryonic foregut morphogenesis (GO:0048617)3.32492287
62male meiosis I (GO:0007141)3.28757400
63regulation of cardiac muscle cell contraction (GO:0086004)3.25370655
64poly(A)+ mRNA export from nucleus (GO:0016973)3.24515905
65negative regulation of DNA repair (GO:0045738)3.18315384
66striated muscle adaptation (GO:0014888)3.17709699
67cellular sodium ion homeostasis (GO:0006883)3.17194807
68creatine metabolic process (GO:0006600)3.17105912
69paraxial mesoderm development (GO:0048339)3.16804764
70gene silencing by RNA (GO:0031047)3.14443053
71negative regulation of meiosis (GO:0045835)3.13038216
72muscle fiber development (GO:0048747)3.11350498
73cardiac muscle tissue morphogenesis (GO:0055008)3.08851811
74sodium ion export (GO:0071436)3.07556788
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.04162884
76male sex determination (GO:0030238)3.03341995
77plasma membrane fusion (GO:0045026)3.02970458
78cardiac myofibril assembly (GO:0055003)3.02544220
79relaxation of smooth muscle (GO:0044557)3.01691396
80response to muscle activity (GO:0014850)3.00275724
81body morphogenesis (GO:0010171)2.99817914
82glucocorticoid biosynthetic process (GO:0006704)2.99749434
83muscle contraction (GO:0006936)2.99736544
84ventricular cardiac muscle cell action potential (GO:0086005)2.99308044
85negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.98907222
86genitalia morphogenesis (GO:0035112)2.98276727
87otic vesicle formation (GO:0030916)2.95128565
88muscle tissue morphogenesis (GO:0060415)2.95072105
89regulation of striated muscle contraction (GO:0006942)2.93023823
90cilium or flagellum-dependent cell motility (GO:0001539)2.91402950
91heterochromatin organization (GO:0070828)2.87079973
92striated muscle cell development (GO:0055002)2.86553828
93endocardial cushion development (GO:0003197)2.85186528
94muscle cell cellular homeostasis (GO:0046716)2.84883711
95muscle system process (GO:0003012)2.83565092
96atrial septum morphogenesis (GO:0060413)2.80850821
97myotube cell development (GO:0014904)2.79382325
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.78787463
99intraciliary transport (GO:0042073)2.74846216
100mitotic chromosome condensation (GO:0007076)2.72824648
101regulation of heart rate (GO:0002027)2.65111200
102meiosis I (GO:0007127)2.64841877
103cardiac muscle cell action potential (GO:0086001)2.64746056
104negative regulation of potassium ion transmembrane transport (GO:1901380)2.64197939
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.63879478
106ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.61387560
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61152237
108glomerular basement membrane development (GO:0032836)2.61008464
109limb bud formation (GO:0060174)2.59915829
110dorsal/ventral axis specification (GO:0009950)2.59854876
111regulation of cardioblast differentiation (GO:0051890)2.59815207
112metanephric mesenchyme development (GO:0072075)2.59271899
113cardiac chamber formation (GO:0003207)2.58260075
114establishment of apical/basal cell polarity (GO:0035089)2.54298326
115regulation of acyl-CoA biosynthetic process (GO:0050812)2.52738493
116cilium movement (GO:0003341)2.51290670
117response to epinephrine (GO:0071871)2.51120922
118carnitine shuttle (GO:0006853)2.50333949
119regulation of cAMP-dependent protein kinase activity (GO:2000479)2.50274059
120skeletal muscle fiber development (GO:0048741)2.50226158
121cardiac conduction (GO:0061337)2.48597134
122muscle cell development (GO:0055001)2.47810886
123regulation of sarcomere organization (GO:0060297)2.47202258
124left/right pattern formation (GO:0060972)2.47063272
125glucocorticoid receptor signaling pathway (GO:0042921)2.45203184
126kidney mesenchyme development (GO:0072074)2.45048111
127notochord development (GO:0030903)2.45036647
128bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44210210
129cellular response to epinephrine stimulus (GO:0071872)2.44109724
130regulation of transforming growth factor beta2 production (GO:0032909)2.44080900
131regulation of calcium ion transmembrane transport (GO:1903169)2.43896735
132regulation of calcium ion transmembrane transporter activity (GO:1901019)2.43896735
133epithelial cilium movement (GO:0003351)2.43622262
134plasma membrane repair (GO:0001778)2.43571289
135negative regulation of hormone biosynthetic process (GO:0032353)2.43539046
136DNA replication-dependent nucleosome organization (GO:0034723)2.43197545
137DNA replication-dependent nucleosome assembly (GO:0006335)2.43197545
138pore complex assembly (GO:0046931)2.42546782
139muscle cell fate commitment (GO:0042693)2.41672616
140cardiac muscle cell action potential involved in contraction (GO:0086002)2.41005770
141positive regulation of response to oxidative stress (GO:1902884)2.40366320
142positive regulation of cellular response to oxidative stress (GO:1900409)2.40366320
143cardiac right ventricle morphogenesis (GO:0003215)2.40061272
144vascular smooth muscle contraction (GO:0014829)2.40052865
145regulation of RNA export from nucleus (GO:0046831)2.39937131
146myotube differentiation (GO:0014902)2.39539318
147regulation of cardiac muscle contraction (GO:0055117)2.38827163
148spermatid development (GO:0007286)2.38139599
149response to misfolded protein (GO:0051788)2.37699592
150anatomical structure regression (GO:0060033)2.37229024
151neuromuscular junction development (GO:0007528)2.37205842
152hippo signaling (GO:0035329)2.37120972
153mitotic sister chromatid cohesion (GO:0007064)2.37062991
154peptidyl-lysine dimethylation (GO:0018027)2.36226842
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.35730751
156axon extension involved in axon guidance (GO:0048846)2.35730751
157tricarboxylic acid cycle (GO:0006099)2.35616187
158germ cell development (GO:0007281)2.35597038
159response to parathyroid hormone (GO:0071107)2.35208947
160ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.35003504
161cardiac ventricle formation (GO:0003211)2.34305246
162negative regulation of calcium ion transmembrane transport (GO:1903170)2.33772622
163negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.33772622
164regulation of meiosis (GO:0040020)2.32819352
165meiotic cell cycle process (GO:1903046)2.31399156
166axonemal dynein complex assembly (GO:0070286)2.31364849
167histone H4-K8 acetylation (GO:0043982)2.31348609
168histone H4-K5 acetylation (GO:0043981)2.31348609
169establishment of monopolar cell polarity (GO:0061162)2.30791697
170establishment or maintenance of monopolar cell polarity (GO:0061339)2.30791697
171pre-miRNA processing (GO:0031054)2.30746294
172histone H4-K12 acetylation (GO:0043983)2.30471540
173epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30332372
174histone H2A acetylation (GO:0043968)2.29993153
175chromatin assembly (GO:0031497)2.29991107
176gene silencing (GO:0016458)2.29615041
177embryonic body morphogenesis (GO:0010172)2.29486350
178polarized epithelial cell differentiation (GO:0030859)2.28966883
179regulation of secondary heart field cardioblast proliferation (GO:0003266)2.28901752
180regulation of cardioblast proliferation (GO:0003264)2.28901752
181mesenchyme development (GO:0060485)2.28411506
182positive regulation of receptor biosynthetic process (GO:0010870)2.26113355
183DNA alkylation (GO:0006305)2.25656430
184DNA methylation (GO:0006306)2.25656430
185membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.25264292
186mesoderm formation (GO:0001707)2.25128370
187negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.24705423
188negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.24463165
189multicellular organismal aging (GO:0010259)2.21777223
190chaperone-mediated protein complex assembly (GO:0051131)2.21480986
191embryonic heart tube development (GO:0035050)2.21069686
192regulation of gonadotropin secretion (GO:0032276)2.20310694
193outflow tract septum morphogenesis (GO:0003148)2.19957818
194regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.19335333
195binding of sperm to zona pellucida (GO:0007339)2.18640394
196macroautophagy (GO:0016236)2.18278128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.99657996
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65490796
3EZH2_22144423_ChIP-Seq_EOC_Human3.59443086
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31432997
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.30997042
6GBX2_23144817_ChIP-Seq_PC3_Human3.18889225
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.04928624
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.77467484
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64350489
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46359931
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24863170
12PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.21962118
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.18965621
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16495542
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14442235
16IGF1R_20145208_ChIP-Seq_DFB_Human2.12206419
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07074123
18ZNF274_21170338_ChIP-Seq_K562_Hela1.99921584
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95220917
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90613373
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.85693033
22AR_21909140_ChIP-Seq_LNCAP_Human1.85074977
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.84938056
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84703219
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84703219
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84703219
27* TAF15_26573619_Chip-Seq_HEK293_Human1.83282519
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.82312448
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.79096423
30* RNF2_27304074_Chip-Seq_NSC_Mouse1.78884024
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77113702
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75361361
33VDR_22108803_ChIP-Seq_LS180_Human1.74932183
34FUS_26573619_Chip-Seq_HEK293_Human1.72339930
35CLOCK_20551151_ChIP-Seq_293T_Human1.69392539
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66536105
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.66198835
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64815571
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64160473
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63559801
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62534231
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62534231
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56275629
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52973739
45P300_19829295_ChIP-Seq_ESCs_Human1.52762611
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52687121
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51421368
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50576130
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47736792
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47514579
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.46138249
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45232177
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.44340413
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42319975
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.42129323
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41435739
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.40633764
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40583765
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40238923
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38387657
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.36262762
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35467115
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34688089
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34281062
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34100761
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32634046
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31659387
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30875253
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.29894241
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29359027
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29034110
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28837363
73EWS_26573619_Chip-Seq_HEK293_Human1.27474170
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26980016
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26914044
76GATA1_22025678_ChIP-Seq_K562_Human1.25979564
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25725634
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25205059
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24731680
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24722090
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24298584
82AR_21572438_ChIP-Seq_LNCaP_Human1.22960703
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22906794
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22905042
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22905042
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.22235777
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22198049
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.22082402
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22002638
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.21907933
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21658958
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21495257
93E2F7_22180533_ChIP-Seq_HELA_Human1.21053842
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.20943679
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20894421
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20644381
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20644381
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20382826
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19769356
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19742001
101CHD1_26751641_Chip-Seq_LNCaP_Human1.18594721
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18369724
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17731500
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17428365
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17381159
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16876415
107MYC_18555785_ChIP-Seq_MESCs_Mouse1.16766782
108* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16552510
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16077696
110REST_19997604_ChIP-ChIP_NEURONS_Mouse1.16034126
111* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15389704
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14412644
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14110018
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13946672
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13721449
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13373770
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13060979
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.12656653
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12253739
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12240395
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11421273
122* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11292335
123ELK1_19687146_ChIP-ChIP_HELA_Human1.11166472
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09106290
125TCF4_23295773_ChIP-Seq_U87_Human1.09095271
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08720893
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.07478510
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.07478510
129AR_25329375_ChIP-Seq_VCAP_Human1.07433784
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07218922
131HTT_18923047_ChIP-ChIP_STHdh_Human1.06032005
132BCAT_22108803_ChIP-Seq_LS180_Human1.05997314
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05893020
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05027369
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03440914
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02376070
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01583730
138SOX17_20123909_ChIP-Seq_XEN_Mouse1.01307392
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01151219
140AHR_22903824_ChIP-Seq_MCF-7_Human1.00432668
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99871276
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98847101
143STAT3_23295773_ChIP-Seq_U87_Human0.98786039
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98631319
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.98434408
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98391781
147EGR1_19374776_ChIP-ChIP_THP-1_Human0.98043456
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97918753
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97814369
150SOX2_16153702_ChIP-ChIP_HESCs_Human0.97684783
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97604073
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96299614
153SOX9_26525672_Chip-Seq_HEART_Mouse0.95885581
154CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94121384
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91861429
156BRD4_25478319_ChIP-Seq_HGPS_Human0.91778414
157NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86988200
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.86717964
159CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86098742
160GATA4_21415370_ChIP-Seq_HL-1_Mouse0.84822850
161HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83802410
162XRN2_22483619_ChIP-Seq_HELA_Human0.83651499
163TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83133519
164MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81957243
165POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81945928
166PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80125688
167SMAD4_21799915_ChIP-Seq_A2780_Human0.79569899
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.79399413
169TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78236523
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77271615
171CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76444847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.57912505
2MP0003122_maternal_imprinting4.12915709
3MP0003123_paternal_imprinting4.10473248
4MP0003121_genomic_imprinting3.26980068
5MP0008995_early_reproductive_senescence3.01338204
6MP0003646_muscle_fatigue2.95211803
7MP0004215_abnormal_myocardial_fiber2.94708449
8MP0008775_abnormal_heart_ventricle2.79141750
9MP0004272_abnormal_basement_membrane2.51954464
10MP0003878_abnormal_ear_physiology2.32537447
11MP0005377_hearing/vestibular/ear_phenot2.32537447
12MP0000013_abnormal_adipose_tissue2.31166748
13MP0000537_abnormal_urethra_morphology2.28310541
14MP0005620_abnormal_muscle_contractility2.23679798
15MP0002106_abnormal_muscle_physiology2.19481166
16MP0004087_abnormal_muscle_fiber2.19133766
17MP0005330_cardiomyopathy2.18546042
18MP0004270_analgesia1.96801235
19MP0005369_muscle_phenotype1.93321259
20MP0003942_abnormal_urinary_system1.90792872
21MP0002972_abnormal_cardiac_muscle1.90602855
22MP0000566_synostosis1.90525951
23MP0005623_abnormal_meninges_morphology1.84591471
24MP0002269_muscular_atrophy1.82299311
25MP0000750_abnormal_muscle_regeneration1.79978272
26MP0004084_abnormal_cardiac_muscle1.79792552
27MP0002210_abnormal_sex_determination1.69996710
28MP0009384_cardiac_valve_regurgitation1.69241575
29MP0003786_premature_aging1.68416052
30MP0003283_abnormal_digestive_organ1.58548227
31MP0003787_abnormal_imprinting1.57569973
32MP0008004_abnormal_stomach_pH1.56578292
33MP0010630_abnormal_cardiac_muscle1.55553514
34MP0008057_abnormal_DNA_replication1.54685936
35MP0008438_abnormal_cutaneous_collagen1.53899468
36MP0000759_abnormal_skeletal_muscle1.53592385
37MP0004510_myositis1.53293549
38MP0004085_abnormal_heartbeat1.53169248
39MP0003119_abnormal_digestive_system1.50339853
40MP0003115_abnormal_respiratory_system1.50325024
41MP0004484_altered_response_of1.49754032
42MP0000747_muscle_weakness1.47361049
43MP0001929_abnormal_gametogenesis1.47329708
44MP0001145_abnormal_male_reproductive1.45412457
45MP0003385_abnormal_body_wall1.44647704
46MP0005410_abnormal_fertilization1.42474192
47MP0004145_abnormal_muscle_electrophysio1.40789429
48MP0005503_abnormal_tendon_morphology1.39956057
49MP0002837_dystrophic_cardiac_calcinosis1.38345371
50MP0005645_abnormal_hypothalamus_physiol1.34936244
51MP0004197_abnormal_fetal_growth/weight/1.31819130
52MP0004233_abnormal_muscle_weight1.31010502
53MP0003698_abnormal_male_reproductive1.30468043
54MP0009053_abnormal_anal_canal1.28188558
55MP0004130_abnormal_muscle_cell1.27512111
56MP0003315_abnormal_perineum_morphology1.27176733
57MP0010030_abnormal_orbit_morphology1.26479961
58MP0000428_abnormal_craniofacial_morphol1.26183049
59MP0009780_abnormal_chondrocyte_physiolo1.25447896
60MP0005385_cardiovascular_system_phenoty1.24794835
61MP0001544_abnormal_cardiovascular_syste1.24794835
62MP0000653_abnormal_sex_gland1.24029228
63MP0003890_abnormal_embryonic-extraembry1.23740147
64MP0003937_abnormal_limbs/digits/tail_de1.23355802
65MP0003137_abnormal_impulse_conducting1.23314748
66MP0003880_abnormal_central_pattern1.20696262
67MP0002084_abnormal_developmental_patter1.20114198
68MP0004036_abnormal_muscle_relaxation1.19777618
69MP0003705_abnormal_hypodermis_morpholog1.16811046
70MP0000751_myopathy1.16471771
71MP0000534_abnormal_ureter_morphology1.15704952
72MP0002160_abnormal_reproductive_system1.15100968
73MP0006072_abnormal_retinal_apoptosis1.14033472
74MP0001727_abnormal_embryo_implantation1.12535028
75MP0006138_congestive_heart_failure1.11799611
76MP0002938_white_spotting1.11124698
77MP0001984_abnormal_olfaction1.10557178
78MP0000003_abnormal_adipose_tissue1.10229781
79MP0010386_abnormal_urinary_bladder1.09706522
80MP0002876_abnormal_thyroid_physiology1.08605569
81MP0001529_abnormal_vocalization1.08201569
82MP0000631_abnormal_neuroendocrine_gland1.07146784
83MP0001299_abnormal_eye_distance/1.06544836
84MP0000462_abnormal_digestive_system1.06444031
85MP0004957_abnormal_blastocyst_morpholog1.06293051
86MP0005248_abnormal_Harderian_gland1.06118025
87MP0001730_embryonic_growth_arrest1.04136313
88MP0003935_abnormal_craniofacial_develop1.02456040
89MP0003567_abnormal_fetal_cardiomyocyte1.02408377
90MP0005076_abnormal_cell_differentiation1.01386769
91MP0009703_decreased_birth_body0.98285334
92MP0002234_abnormal_pharynx_morphology0.97689811
93MP0004859_abnormal_synaptic_plasticity0.97489151
94MP0000049_abnormal_middle_ear0.97219177
95MP0009250_abnormal_appendicular_skeleto0.97108137
96MP0003195_calcinosis0.94687176
97MP0006276_abnormal_autonomic_nervous0.94134031
98MP0002085_abnormal_embryonic_tissue0.93404886
99MP0001697_abnormal_embryo_size0.93372828
100MP0002822_catalepsy0.92259159
101MP0000733_abnormal_muscle_development0.91419881
102MP0002734_abnormal_mechanical_nocicepti0.89927380
103MP0005380_embryogenesis_phenotype0.89116816
104MP0001672_abnormal_embryogenesis/_devel0.89116816
105MP0002638_abnormal_pupillary_reflex0.88703195
106MP0002088_abnormal_embryonic_growth/wei0.88632495
107MP0008932_abnormal_embryonic_tissue0.88526728
108MP0003755_abnormal_palate_morphology0.88522967
109MP0002332_abnormal_exercise_endurance0.88413928
110MP0003984_embryonic_growth_retardation0.88027751
111MP0002697_abnormal_eye_size0.87904426
112MP0009672_abnormal_birth_weight0.87598963
113MP0003045_fibrosis0.87233353
114MP0008007_abnormal_cellular_replicative0.87227792
115MP0002108_abnormal_muscle_morphology0.84394300
116MP0002116_abnormal_craniofacial_bone0.82455539
117MP0003941_abnormal_skin_development0.82080851
118MP0002282_abnormal_trachea_morphology0.81927048
119MP0002896_abnormal_bone_mineralization0.81651827
120MP0000678_abnormal_parathyroid_gland0.81544794
121MP0006054_spinal_hemorrhage0.81271209
122MP0002233_abnormal_nose_morphology0.80621872
123MP0002127_abnormal_cardiovascular_syste0.80550476
124MP0002168_other_aberrant_phenotype0.80400197
125MP0002086_abnormal_extraembryonic_tissu0.80181530
126MP0005187_abnormal_penis_morphology0.79505315
127MP0002751_abnormal_autonomic_nervous0.79468252
128MP0003221_abnormal_cardiomyocyte_apopto0.78804833
129MP0003936_abnormal_reproductive_system0.78165212
130MP0001486_abnormal_startle_reflex0.77516211
131MP0000516_abnormal_urinary_system0.77034772
132MP0005367_renal/urinary_system_phenotyp0.77034772
133MP0001346_abnormal_lacrimal_gland0.77026967
134MP0003635_abnormal_synaptic_transmissio0.76145675
135MP0002254_reproductive_system_inflammat0.76074758
136MP0005394_taste/olfaction_phenotype0.75584975
137MP0005499_abnormal_olfactory_system0.75584975
138MP0001661_extended_life_span0.74637351
139MP0000778_abnormal_nervous_system0.74473094
140MP0003077_abnormal_cell_cycle0.73707277
141MP0002102_abnormal_ear_morphology0.71729259
142MP0000266_abnormal_heart_morphology0.71372782
143MP0000639_abnormal_adrenal_gland0.71258126
144MP0005389_reproductive_system_phenotype0.71102829
145MP0002909_abnormal_adrenal_gland0.70456488
146MP0000749_muscle_degeneration0.70050722
147MP0008789_abnormal_olfactory_epithelium0.69136963
148MP0002557_abnormal_social/conspecific_i0.66231474
149MP0000579_abnormal_nail_morphology0.66081173
150MP0002272_abnormal_nervous_system0.63618715
151MP0004924_abnormal_behavior0.63112596
152MP0005386_behavior/neurological_phenoty0.63112596
153MP0002063_abnormal_learning/memory/cond0.61555387
154MP0000383_abnormal_hair_follicle0.60386877
155MP0005275_abnormal_skin_tensile0.59953064
156MP0005423_abnormal_somatic_nervous0.57626302
157MP0002971_abnormal_brown_adipose0.56607387
158MP0002064_seizures0.55858379

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.42746477
2Nemaline bodies (HP:0003798)6.41344117
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.26029772
4Calf muscle hypertrophy (HP:0008981)5.32762896
5Muscle hypertrophy of the lower extremities (HP:0008968)5.29514784
6Exercise-induced muscle cramps (HP:0003710)5.13410776
7Exercise-induced myalgia (HP:0003738)4.92574408
8Abnormality of the calf musculature (HP:0001430)4.70552362
9Distal arthrogryposis (HP:0005684)4.53163219
10Sudden death (HP:0001699)4.45956058
1111 pairs of ribs (HP:0000878)4.00263665
12Ventricular tachycardia (HP:0004756)3.76950564
13Missing ribs (HP:0000921)3.72547961
14EMG: myopathic abnormalities (HP:0003458)3.67377740
15Hyporeflexia of lower limbs (HP:0002600)3.57273857
16Bundle branch block (HP:0011710)3.43870191
17Male infertility (HP:0003251)3.43745002
18Gonadotropin excess (HP:0000837)3.42650200
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.35783835
20Abnormality of dentin (HP:0010299)3.30144690
21Round ear (HP:0100830)3.26193798
22Atrial fibrillation (HP:0005110)3.22820664
23Right ventricular cardiomyopathy (HP:0011663)3.20459126
24Gonadal dysgenesis (HP:0000133)3.19264623
25Ulnar deviation of the wrist (HP:0003049)3.14779783
26Testicular neoplasm (HP:0010788)3.10317383
27Muscle fiber splitting (HP:0003555)3.09483731
28Hip contracture (HP:0003273)3.04741092
29Absent phalangeal crease (HP:0006109)3.00475098
30Myopathic facies (HP:0002058)2.96614191
31Neck muscle weakness (HP:0000467)2.94705691
32Subaortic stenosis (HP:0001682)2.90590475
33Abnormality of the left ventricular outflow tract (HP:0011103)2.90590475
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.89918791
35Myoglobinuria (HP:0002913)2.88970064
36Primary atrial arrhythmia (HP:0001692)2.86647440
37Hand muscle atrophy (HP:0009130)2.86029167
38Limited hip movement (HP:0008800)2.84141074
39Supraventricular tachycardia (HP:0004755)2.76786881
40Supraventricular arrhythmia (HP:0005115)2.72508434
41Fibular hypoplasia (HP:0003038)2.65512752
42Difficulty running (HP:0009046)2.61796173
43Asymmetric septal hypertrophy (HP:0001670)2.61253518
44Calcaneovalgus deformity (HP:0001848)2.59479052
45Lipoatrophy (HP:0100578)2.56568198
46Rhabdomyolysis (HP:0003201)2.54355994
47Metaphyseal cupping (HP:0003021)2.52209424
48Hypoventilation (HP:0002791)2.49539106
49Abnormal finger flexion creases (HP:0006143)2.49281727
50Male pseudohermaphroditism (HP:0000037)2.48792653
51EMG: neuropathic changes (HP:0003445)2.48067797
52Dilated cardiomyopathy (HP:0001644)2.46455376
53Occipital encephalocele (HP:0002085)2.44796414
54Myotonia (HP:0002486)2.43551098
55Syncope (HP:0001279)2.37648524
56Protrusio acetabuli (HP:0003179)2.36430785
57Abnormal respiratory motile cilium physiology (HP:0012261)2.36245454
58Subacute progressive viral hepatitis (HP:0006572)2.34330128
59Renal duplication (HP:0000075)2.30196704
60Upper limb amyotrophy (HP:0009129)2.29697851
61Distal upper limb amyotrophy (HP:0007149)2.29697851
62Bell-shaped thorax (HP:0001591)2.29391180
63Rimmed vacuoles (HP:0003805)2.27199126
64Shoulder girdle muscle weakness (HP:0003547)2.26980625
65Abnormality of the calcaneus (HP:0008364)2.26632824
66Ventricular arrhythmia (HP:0004308)2.25436588
67Abnormal ventriculo-arterial connection (HP:0011563)2.25055974
68Transposition of the great arteries (HP:0001669)2.25055974
69Abnormal connection of the cardiac segments (HP:0011545)2.25055974
70Deformed tarsal bones (HP:0008119)2.24992110
71Bladder diverticulum (HP:0000015)2.23788782
72Popliteal pterygium (HP:0009756)2.22530626
73Rhinitis (HP:0012384)2.22009206
74Fetal akinesia sequence (HP:0001989)2.20473288
75Abnormality of the ischium (HP:0003174)2.17798843
76Embryonal renal neoplasm (HP:0011794)2.16808419
77Papillary thyroid carcinoma (HP:0002895)2.14656112
78Chronic bronchitis (HP:0004469)2.14309036
79Azoospermia (HP:0000027)2.13447493
80Abnormality of the lower motor neuron (HP:0002366)2.13058786
81Diaphragmatic weakness (HP:0009113)2.11906270
82Sex reversal (HP:0012245)2.11751365
83Abnormal sex determination (HP:0012244)2.11751365
84Heart block (HP:0012722)2.08945283
85Nephronophthisis (HP:0000090)2.08730366
86Left ventricular hypertrophy (HP:0001712)2.07943240
87Bifid tongue (HP:0010297)2.07499088
88Cerebral aneurysm (HP:0004944)2.05795897
89Short 4th metacarpal (HP:0010044)2.05664951
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05664951
91Hepatoblastoma (HP:0002884)2.04122546
92Vitreoretinal degeneration (HP:0000655)2.03345143
93Aplasia/Hypoplasia of the fibula (HP:0006492)2.01998021
94Ankle contracture (HP:0006466)2.00677487
95Distal lower limb muscle weakness (HP:0009053)1.99421456
96Areflexia of lower limbs (HP:0002522)1.98021045
97Selective tooth agenesis (HP:0001592)1.97890999
98Hypoplastic left heart (HP:0004383)1.97890883
99Back pain (HP:0003418)1.97817032
100Facial diplegia (HP:0001349)1.96358210
101Increased connective tissue (HP:0009025)1.96131721
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94478209
103Abnormal pancreas size (HP:0012094)1.94191867
104Nephroblastoma (Wilms tumor) (HP:0002667)1.93697798
105Infertility (HP:0000789)1.92387418
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.87912108
107Absent/shortened dynein arms (HP:0200106)1.87912108
108Abnormal atrioventricular conduction (HP:0005150)1.87378711
109Facial cleft (HP:0002006)1.87207392
110Gowers sign (HP:0003391)1.83935508
111Tubulointerstitial nephritis (HP:0001970)1.83310053
112Malignant hyperthermia (HP:0002047)1.82377703
113Oligomenorrhea (HP:0000876)1.82239598
114Aortic aneurysm (HP:0004942)1.81740083
115Hypoplastic ischia (HP:0003175)1.81705609
116Muscular dystrophy (HP:0003560)1.80213941
117Tubular atrophy (HP:0000092)1.80052810
118Germ cell neoplasia (HP:0100728)1.79475338
119Symphalangism affecting the phalanges of the hand (HP:0009773)1.78612237
120Pelvic girdle muscle weakness (HP:0003749)1.77719836
121Microglossia (HP:0000171)1.76955429
122Abnormality of the aortic arch (HP:0012303)1.76568463
123Abnormal spermatogenesis (HP:0008669)1.76326276
124Spontaneous abortion (HP:0005268)1.75773381
125Vertebral clefting (HP:0008428)1.75768005
126Abnormality of skeletal muscle fiber size (HP:0012084)1.75347338
127Hypoplastic heart (HP:0001961)1.74203537
128Generalized muscle weakness (HP:0003324)1.73611945
129Broad distal phalanx of finger (HP:0009836)1.72351045
130Bowel diverticulosis (HP:0005222)1.71870504
131Abnormal ciliary motility (HP:0012262)1.71668539
132Abnormality of the musculature of the hand (HP:0001421)1.70080344
133Muscle stiffness (HP:0003552)1.68328155
134Increased variability in muscle fiber diameter (HP:0003557)1.67031524
135Thin ribs (HP:0000883)1.65369917
136Mildly elevated creatine phosphokinase (HP:0008180)1.64515790
137Spinal rigidity (HP:0003306)1.63723553
138Broad long bones (HP:0005622)1.62335993
139Scapular winging (HP:0003691)1.62191694
140Premature rupture of membranes (HP:0001788)1.62120283
141Muscle fibrillation (HP:0010546)1.61726295
142Patent foramen ovale (HP:0001655)1.61197293
143Abnormality of the hip-girdle musculature (HP:0001445)1.61114398
144Abnormality of the musculature of the pelvis (HP:0001469)1.61114398
145Hypoplasia of the uterus (HP:0000013)1.60836387
146Steppage gait (HP:0003376)1.60740479
147Limb dystonia (HP:0002451)1.59838638
148Stridor (HP:0010307)1.59648661
149Supernumerary spleens (HP:0009799)1.59288654
150Metatarsus adductus (HP:0001840)1.59237053
151Tongue fasciculations (HP:0001308)1.58432227
152Broad phalanges of the hand (HP:0009768)1.58390382
153Abnormality of the 4th metacarpal (HP:0010012)1.57853685
154Abnormality of the anterior horn cell (HP:0006802)1.57726062
155Degeneration of anterior horn cells (HP:0002398)1.57726062
156Short thorax (HP:0010306)1.57393407
157Neoplasm of the heart (HP:0100544)1.57303396
158Broad finger (HP:0001500)1.57238061
159Molar tooth sign on MRI (HP:0002419)1.57166276
160Abnormality of midbrain morphology (HP:0002418)1.57166276
161Soft skin (HP:0000977)1.56872994
162Long clavicles (HP:0000890)1.55576392
163Broad phalanx (HP:0006009)1.54954551
164Thyroid carcinoma (HP:0002890)1.54915208
165Limb-girdle muscle weakness (HP:0003325)1.54877630
166Buphthalmos (HP:0000557)1.54873184
167Ovarian neoplasm (HP:0100615)1.54582644
168Broad thumb (HP:0011304)1.53452666
169Type 1 muscle fiber predominance (HP:0003803)1.52729125
170Toxemia of pregnancy (HP:0100603)1.51991384
171Focal motor seizures (HP:0011153)1.51073168
172Absent eyebrow (HP:0002223)1.50693304
173Atonic seizures (HP:0010819)1.50261342
174Cutaneous finger syndactyly (HP:0010554)1.47409767
175Abnormality of the shoulder girdle musculature (HP:0001435)1.45753893
176Palpitations (HP:0001962)1.45263785
177Frequent falls (HP:0002359)1.43674174
178Abnormality of the pubic bones (HP:0003172)1.43177164
179Double outlet right ventricle (HP:0001719)1.42522573
180Congenital malformation of the right heart (HP:0011723)1.42522573
181Waddling gait (HP:0002515)1.40639875
182Cutaneous syndactyly (HP:0012725)1.39682940
183Proximal amyotrophy (HP:0007126)1.39616658
184Myokymia (HP:0002411)1.39600057
185Abnormal tarsal ossification (HP:0008369)1.39528102
186Hyperkalemia (HP:0002153)1.38207003
187Hyperglycemia (HP:0003074)1.37950147
188Vaginal atresia (HP:0000148)1.37414282
189Short tibia (HP:0005736)1.35476430
190Genital tract atresia (HP:0001827)1.35193314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.19263842
2PRKD33.44319679
3CDK123.27896761
4PHKG13.19895055
5PHKG23.19895055
6EPHA42.88906503
7CASK2.38264438
8WNK42.17377969
9CDC72.12610073
10MAPK152.11863203
11PASK2.06530268
12STK38L2.03915022
13LATS11.99244343
14BRD41.96950838
15TESK11.96640429
16PNCK1.93498420
17BRSK21.91444254
18MARK11.86840800
19PDK31.85026507
20PDK41.85026507
21LATS21.78562016
22MAP3K121.77806856
23PINK11.77304248
24MYLK1.75695071
25FGFR21.66532823
26OBSCN1.60051061
27WEE11.57566190
28ERBB31.56612058
29LIMK11.56052338
30TNIK1.51764997
31PTK2B1.50719649
32MAP3K41.50067036
33PDGFRA1.49711866
34WNK11.46243803
35PTK61.45279304
36CDC42BPA1.40605298
37CAMK41.40422830
38TYRO31.29575647
39CAMK11.28385060
40PIK3CA1.27789148
41STK31.27754646
42SCYL21.21688742
43PAK21.20255869
44PTK21.19377199
45PAK31.19236758
46MAP2K41.19129076
47TRIB31.18216120
48PKN21.16780323
49PLK31.16254967
50FER1.16113222
51CDK91.16078299
52TIE11.08777830
53MTOR1.08521119
54CAMK1G1.08402679
55AKT31.05432024
56FRK1.04754491
57CDK71.02037773
58TTN1.00530571
59CDK80.99081955
60DDR20.98907285
61NEK20.96594208
62SGK20.94849402
63CAMK1D0.94194223
64TGFBR10.94070418
65FGFR10.90097503
66ICK0.89341459
67DMPK0.89340321
68BCR0.89329449
69STK240.89167303
70PLK10.87985114
71PLK40.87940608
72PLK20.87767292
73TSSK60.87584773
74SGK4940.86781291
75SGK2230.86781291
76MAPK120.84738966
77CAMK2A0.83337915
78MKNK10.82287635
79BRSK10.82201120
80SRPK10.82086212
81ATM0.80968566
82MAP3K70.80761697
83BMPR1B0.78558863
84PRKAA10.78243094
85DAPK20.77937768
86CHEK10.76675260
87MKNK20.74744390
88SGK30.74278954
89CAMK2G0.74106392
90PAK40.73051747
91MAP3K50.72688880
92CCNB10.72499564
93STK390.72277448
94CAMK2D0.71276369
95PIK3CG0.70773876
96MAPKAPK30.68856214
97MAP3K90.68769032
98TRIM280.68632964
99CAMK2B0.68106303
100PDK20.67597727
101NTRK20.67205220
102RIPK10.65709519
103EPHA20.65686773
104PRKAA20.65159609
105ATR0.65125199
106MAP4K20.64529215
107STK380.61344129
108MELK0.60919070
109AKT20.60762535
110NTRK30.60381707
111ROCK10.60375759
112UHMK10.60013106
113MET0.59847032
114CDK50.59829901
115MAP3K20.59531738
116ACVR1B0.58460758
117PRKDC0.58071983
118MUSK0.58057638
119PRKCE0.58032842
120NLK0.57291769
121NME10.56487564
122MAP3K100.56290563
123PRKG10.55032280
124EPHB20.54752356
125FLT30.53879395
126CDK10.52725833
127CSNK1G30.51915182
128PAK60.51393208
129RET0.50167235
130DAPK30.48549307
131OXSR10.47255685
132ZAK0.46967061
133PRKACA0.46760719
134AURKB0.45010730
135CHEK20.44742428
136RPS6KB10.44632787
137CDK20.44588647
138DYRK30.44430053
139MAP2K10.44272642
140LMTK20.44161744
141KSR10.43181503
142VRK10.42758740
143TTK0.41955463
144DYRK20.41152478
145CSNK1A1L0.41088036
146CSNK1E0.40496153
147ILK0.40375197
148PRKCG0.39810660
149CSNK1G10.39521372
150RPS6KA50.39483704
151STK110.39386582
152NUAK10.38491496
153PRKACG0.38439392
154DYRK1A0.37799337
155MINK10.37669495
156CSNK1G20.36418521
157ROCK20.36343071
158CDK190.35867168
159RPS6KA30.35680122
160PRKACB0.35639655
161MAP2K70.35025219
162NEK90.32894949
163PRKD10.31012940
164SGK10.30925334

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.75927841
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43436304
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41598460
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.27090643
5mRNA surveillance pathway_Homo sapiens_hsa030152.25187876
6Propanoate metabolism_Homo sapiens_hsa006402.20834533
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.17399765
8RNA transport_Homo sapiens_hsa030132.08314034
9Hedgehog signaling pathway_Homo sapiens_hsa043402.02080189
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94026931
11Cell cycle_Homo sapiens_hsa041101.87775432
12Oocyte meiosis_Homo sapiens_hsa041141.83410999
13TGF-beta signaling pathway_Homo sapiens_hsa043501.80956330
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.75855081
15Basal transcription factors_Homo sapiens_hsa030221.74806880
16Hippo signaling pathway_Homo sapiens_hsa043901.71754357
17Basal cell carcinoma_Homo sapiens_hsa052171.68388145
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67740952
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59202028
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58135539
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57400595
22Cocaine addiction_Homo sapiens_hsa050301.52305516
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52120183
24ECM-receptor interaction_Homo sapiens_hsa045121.51968942
25Tight junction_Homo sapiens_hsa045301.49550187
26Cardiac muscle contraction_Homo sapiens_hsa042601.49443787
27Dorso-ventral axis formation_Homo sapiens_hsa043201.45110850
28Dilated cardiomyopathy_Homo sapiens_hsa054141.45076916
29Focal adhesion_Homo sapiens_hsa045101.41370061
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40250188
31Spliceosome_Homo sapiens_hsa030401.35137562
32Glucagon signaling pathway_Homo sapiens_hsa049221.34856199
33Huntingtons disease_Homo sapiens_hsa050161.32868701
34Steroid biosynthesis_Homo sapiens_hsa001001.32524602
35Alcoholism_Homo sapiens_hsa050341.29576522
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28967938
37Adherens junction_Homo sapiens_hsa045201.26516384
38Insulin secretion_Homo sapiens_hsa049111.26296529
39Amphetamine addiction_Homo sapiens_hsa050311.25580506
40Arginine and proline metabolism_Homo sapiens_hsa003301.25508323
41Fatty acid degradation_Homo sapiens_hsa000711.23784833
42Arginine biosynthesis_Homo sapiens_hsa002201.23783872
43RNA degradation_Homo sapiens_hsa030181.23646467
44Wnt signaling pathway_Homo sapiens_hsa043101.22478079
45Parkinsons disease_Homo sapiens_hsa050121.17531712
46Fatty acid metabolism_Homo sapiens_hsa012121.17246499
47Carbon metabolism_Homo sapiens_hsa012001.17141066
48Calcium signaling pathway_Homo sapiens_hsa040201.15264325
49Phenylalanine metabolism_Homo sapiens_hsa003601.15015643
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14370052
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13220868
52Vibrio cholerae infection_Homo sapiens_hsa051101.13001907
53Nicotine addiction_Homo sapiens_hsa050331.12524990
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11382125
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08367948
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07317951
57Circadian entrainment_Homo sapiens_hsa047131.04919585
58Nucleotide excision repair_Homo sapiens_hsa034201.04831866
59Estrogen signaling pathway_Homo sapiens_hsa049151.04805781
60Fatty acid elongation_Homo sapiens_hsa000621.04113190
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03660716
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.02635991
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01437486
64Thyroid hormone synthesis_Homo sapiens_hsa049181.00809531
65N-Glycan biosynthesis_Homo sapiens_hsa005101.00486458
66Melanogenesis_Homo sapiens_hsa049160.98698844
67Gastric acid secretion_Homo sapiens_hsa049710.96707882
68Dopaminergic synapse_Homo sapiens_hsa047280.96503939
69Protein digestion and absorption_Homo sapiens_hsa049740.95862542
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.95002375
71Pancreatic secretion_Homo sapiens_hsa049720.94965523
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94287527
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93563221
74Fatty acid biosynthesis_Homo sapiens_hsa000610.92586038
75Butanoate metabolism_Homo sapiens_hsa006500.91864108
76Proteoglycans in cancer_Homo sapiens_hsa052050.91808636
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91352436
78Small cell lung cancer_Homo sapiens_hsa052220.89133002
79Starch and sucrose metabolism_Homo sapiens_hsa005000.88616698
80Thyroid cancer_Homo sapiens_hsa052160.88029971
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87557987
82beta-Alanine metabolism_Homo sapiens_hsa004100.85475206
83Prostate cancer_Homo sapiens_hsa052150.82127068
84Mismatch repair_Homo sapiens_hsa034300.81447056
85Bile secretion_Homo sapiens_hsa049760.80792042
86Renin secretion_Homo sapiens_hsa049240.80588796
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.80480204
88Oxidative phosphorylation_Homo sapiens_hsa001900.80469766
89Lysine degradation_Homo sapiens_hsa003100.78736791
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77489974
91Axon guidance_Homo sapiens_hsa043600.76160990
92HTLV-I infection_Homo sapiens_hsa051660.75026720
93GABAergic synapse_Homo sapiens_hsa047270.73163460
94Amoebiasis_Homo sapiens_hsa051460.73037753
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72098300
96Histidine metabolism_Homo sapiens_hsa003400.71987097
97Tyrosine metabolism_Homo sapiens_hsa003500.71828332
98MicroRNAs in cancer_Homo sapiens_hsa052060.71602701
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71383867
100Viral carcinogenesis_Homo sapiens_hsa052030.71201559
101Pathways in cancer_Homo sapiens_hsa052000.71131614
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70697460
103Fanconi anemia pathway_Homo sapiens_hsa034600.70182807
104Homologous recombination_Homo sapiens_hsa034400.69496681
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67088481
106Endometrial cancer_Homo sapiens_hsa052130.66726274
107Gap junction_Homo sapiens_hsa045400.66474585
108Ovarian steroidogenesis_Homo sapiens_hsa049130.66093190
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64952725
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64549458
111Insulin signaling pathway_Homo sapiens_hsa049100.64192209
112Fat digestion and absorption_Homo sapiens_hsa049750.63620537
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63236274
114Tryptophan metabolism_Homo sapiens_hsa003800.63011485
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62435300
116Chemical carcinogenesis_Homo sapiens_hsa052040.61690723
117mTOR signaling pathway_Homo sapiens_hsa041500.60526041
118Pyruvate metabolism_Homo sapiens_hsa006200.60465522
119Long-term potentiation_Homo sapiens_hsa047200.59781469
120Salivary secretion_Homo sapiens_hsa049700.59731498
121Glutamatergic synapse_Homo sapiens_hsa047240.58546774
122Sulfur metabolism_Homo sapiens_hsa009200.58349229
123PPAR signaling pathway_Homo sapiens_hsa033200.58336941
124Insulin resistance_Homo sapiens_hsa049310.58331746
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58275487
126Colorectal cancer_Homo sapiens_hsa052100.58129652
127Type II diabetes mellitus_Homo sapiens_hsa049300.57516539
128Biosynthesis of amino acids_Homo sapiens_hsa012300.56300748
129RNA polymerase_Homo sapiens_hsa030200.56281503
130cAMP signaling pathway_Homo sapiens_hsa040240.56195971
131Proteasome_Homo sapiens_hsa030500.56159609
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56153807
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56075991
134Selenocompound metabolism_Homo sapiens_hsa004500.55781684
135Antigen processing and presentation_Homo sapiens_hsa046120.55352295
136Olfactory transduction_Homo sapiens_hsa047400.54514214
137Alzheimers disease_Homo sapiens_hsa050100.54154581
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54070001
139Type I diabetes mellitus_Homo sapiens_hsa049400.53568315
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52263070
141AMPK signaling pathway_Homo sapiens_hsa041520.51880302
142Synaptic vesicle cycle_Homo sapiens_hsa047210.51434966
143Peroxisome_Homo sapiens_hsa041460.51370092
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49640799
145Mineral absorption_Homo sapiens_hsa049780.49605813
146Circadian rhythm_Homo sapiens_hsa047100.49550930
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.49229200
148Oxytocin signaling pathway_Homo sapiens_hsa049210.49122854
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48001788
150Glutathione metabolism_Homo sapiens_hsa004800.47122268
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46867039
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.46581181
153p53 signaling pathway_Homo sapiens_hsa041150.45746875
154Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45140918
155Complement and coagulation cascades_Homo sapiens_hsa046100.44624017

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