MUS81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after interstrand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)7.00679654
2pyrimidine dimer repair (GO:0006290)5.85329679
3multicellular organismal aging (GO:0010259)5.54296219
4DNA deamination (GO:0045006)5.32311294
5negative regulation of erythrocyte differentiation (GO:0045647)5.15297331
6viral transcription (GO:0019083)5.02953175
7translational termination (GO:0006415)4.79159526
8somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.64447099
9somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.64447099
10isotype switching (GO:0045190)4.64447099
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.32530685
12translational elongation (GO:0006414)4.30569445
13respiratory chain complex IV assembly (GO:0008535)4.30068211
14UV protection (GO:0009650)4.29532309
15cotranslational protein targeting to membrane (GO:0006613)4.22965571
16protein targeting to ER (GO:0045047)4.17581073
17ribosomal small subunit assembly (GO:0000028)4.07226540
18mannose metabolic process (GO:0006013)4.03895998
19NIK/NF-kappaB signaling (GO:0038061)4.02195721
20maturation of SSU-rRNA (GO:0030490)4.00763608
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.97238439
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.97210152
23protein localization to endoplasmic reticulum (GO:0070972)3.94233252
24activation of MAPKKK activity (GO:0000185)3.91166521
25cellular protein complex disassembly (GO:0043624)3.83529510
26somatic recombination of immunoglobulin gene segments (GO:0016447)3.82268762
27viral life cycle (GO:0019058)3.79955318
28regulation of telomere maintenance (GO:0032204)3.68469791
29modulation by symbiont of host defense response (GO:0052031)3.59895160
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59895160
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59895160
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.59895160
33modulation by symbiont of host immune response (GO:0052553)3.59895160
34positive regulation by symbiont of host defense response (GO:0052509)3.59895160
35establishment of integrated proviral latency (GO:0075713)3.59337887
36translational initiation (GO:0006413)3.59154496
37leukocyte aggregation (GO:0070486)3.59016854
38negative regulation of cell size (GO:0045792)3.59009895
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56845884
40antigen processing and presentation of endogenous antigen (GO:0019883)3.55957924
41protein complex disassembly (GO:0043241)3.54969135
42positive regulation of interleukin-8 secretion (GO:2000484)3.50798293
43oxidative phosphorylation (GO:0006119)3.49084011
44somatic diversification of immunoglobulins (GO:0016445)3.48888472
45modulation by virus of host process (GO:0019054)3.45180908
46substrate-independent telencephalic tangential migration (GO:0021826)3.43855524
47substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.43855524
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40660978
49response to peptidoglycan (GO:0032494)3.39928193
50modulation by symbiont of host cellular process (GO:0044068)3.39517294
51response to muramyl dipeptide (GO:0032495)3.39363788
52macromolecular complex disassembly (GO:0032984)3.39037200
53mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35800812
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34569475
55negative regulation of cell killing (GO:0031342)3.34422637
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34422637
57embryonic foregut morphogenesis (GO:0048617)3.28704144
58Peyers patch development (GO:0048541)3.26112164
59mucosal-associated lymphoid tissue development (GO:0048537)3.26112164
60mitotic recombination (GO:0006312)3.21375799
61negative regulation of multicellular organism growth (GO:0040015)3.19787495
62intracellular estrogen receptor signaling pathway (GO:0030520)3.17549651
63somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.17234305
64somatic cell DNA recombination (GO:0016444)3.17234305
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15761287
66negative regulation of granulocyte differentiation (GO:0030853)3.15478019
67proteasome assembly (GO:0043248)3.14957721
68regulation of mitochondrial translation (GO:0070129)3.12141956
69thymic T cell selection (GO:0045061)3.10603083
70galactose catabolic process (GO:0019388)3.10215441
71apoptotic process involved in morphogenesis (GO:0060561)3.09742487
723-UTR-mediated mRNA stabilization (GO:0070935)3.08912489
73nucleotide-excision repair, DNA damage removal (GO:0000718)3.07842894
74DNA excision (GO:0044349)3.07842894
75regulation of monocyte differentiation (GO:0045655)3.07378538
76establishment of viral latency (GO:0019043)3.07265330
77cytochrome complex assembly (GO:0017004)3.07030138
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05835515
79ATP synthesis coupled proton transport (GO:0015986)3.05835515
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05145854
81epithelial cell fate commitment (GO:0072148)3.05031737
82positive regulation of Cdc42 GTPase activity (GO:0043089)3.04877705
83spliceosomal complex assembly (GO:0000245)3.03426110
84somatic diversification of immune receptors (GO:0002200)2.99050949
85DNA strand elongation involved in DNA replication (GO:0006271)2.98309432
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97608243
87transcription-coupled nucleotide-excision repair (GO:0006283)2.94276950
88ubiquinone biosynthetic process (GO:0006744)2.93308013
89quinone biosynthetic process (GO:1901663)2.93308013
90renal absorption (GO:0070293)2.92836397
91DNA strand elongation (GO:0022616)2.92053125
92mitotic metaphase plate congression (GO:0007080)2.91736164
93mitochondrial respiratory chain complex assembly (GO:0033108)2.89764406
94translation (GO:0006412)2.89379693
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89153371
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.89153371
97NADH dehydrogenase complex assembly (GO:0010257)2.89153371
98lymphangiogenesis (GO:0001946)2.88624622
99positive regulation of B cell differentiation (GO:0045579)2.88474962
100erythrocyte maturation (GO:0043249)2.85182963
101protein retention in ER lumen (GO:0006621)2.84830569
102B cell activation involved in immune response (GO:0002312)2.84128876
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83509950
104regulation of defense response to virus by virus (GO:0050690)2.80013193
105protein complex biogenesis (GO:0070271)2.78879115
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78686644
107positive T cell selection (GO:0043368)2.78316161
108regulation of gamma-delta T cell differentiation (GO:0045586)2.77035368
109nuclear-transcribed mRNA catabolic process (GO:0000956)2.76533639
110mitotic chromosome condensation (GO:0007076)2.75635544
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73923633
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73875369
113immunoglobulin mediated immune response (GO:0016064)2.73087257
114positive regulation of histone deacetylation (GO:0031065)2.72606886
115positive thymic T cell selection (GO:0045059)2.72210289
116regulation of mammary gland epithelial cell proliferation (GO:0033599)2.70542648
117binding of sperm to zona pellucida (GO:0007339)2.68596857
118GTP biosynthetic process (GO:0006183)2.68433508
119cellular response to interleukin-4 (GO:0071353)2.68296102
120B cell receptor signaling pathway (GO:0050853)2.67384487
121negative regulation of DNA-templated transcription, elongation (GO:0032785)2.67173843
122cellular response to virus (GO:0098586)2.66619639
123ncRNA 3-end processing (GO:0043628)2.66288916
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65876312
125oogenesis (GO:0048477)2.65212200
126protein targeting to membrane (GO:0006612)2.65197394
127histone H4 deacetylation (GO:0070933)2.65130743
128germinal center formation (GO:0002467)2.64580235
129GDP-mannose metabolic process (GO:0019673)2.64125139
130granulocyte differentiation (GO:0030851)2.63776430
131telomere maintenance via semi-conservative replication (GO:0032201)2.63255145
132T cell migration (GO:0072678)2.63140730
133negative regulation of necroptotic process (GO:0060546)2.62674285
134detection of bacterium (GO:0016045)2.62161048
135UTP biosynthetic process (GO:0006228)2.61459271
136mRNA catabolic process (GO:0006402)2.60428190
137negative thymic T cell selection (GO:0045060)2.60422087
138proline biosynthetic process (GO:0006561)2.59832072
139response to interleukin-4 (GO:0070670)2.59786978
140metaphase plate congression (GO:0051310)2.58996566
141regulation of gamma-delta T cell activation (GO:0046643)2.58809152
142protein maturation by protein folding (GO:0022417)2.58709703
143mature B cell differentiation involved in immune response (GO:0002313)2.58587662
144positive regulation of gamma-delta T cell activation (GO:0046645)2.57898053
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57699016
146ribosomal small subunit biogenesis (GO:0042274)2.56849641
147COPI coating of Golgi vesicle (GO:0048205)2.56007217
148Golgi transport vesicle coating (GO:0048200)2.56007217
149regulation of ARF GTPase activity (GO:0032312)2.55539926
150pyrimidine nucleotide catabolic process (GO:0006244)2.54243477
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53217785
152deoxyribose phosphate catabolic process (GO:0046386)2.50633345
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50370308
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.49457676
155modulation by virus of host morphology or physiology (GO:0019048)2.48564078
156protein localization to endosome (GO:0036010)2.47858363
157regulation of necrotic cell death (GO:0010939)2.46755865
158detection of other organism (GO:0098543)2.46057667
159morphogenesis of an endothelium (GO:0003159)2.45624704
160endothelial tube morphogenesis (GO:0061154)2.45624704
161post-embryonic morphogenesis (GO:0009886)2.45554159
162de novo posttranslational protein folding (GO:0051084)2.45458413
163anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.45329427
164regulation of necroptotic process (GO:0060544)2.45249636
165antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44790895
166positive regulation of protein deacetylation (GO:0090312)2.44765370
167protein insertion into membrane (GO:0051205)2.44749717
168tumor necrosis factor-mediated signaling pathway (GO:0033209)2.44304454
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41430106
170regulation of B cell receptor signaling pathway (GO:0050855)2.41248215
171pentose-phosphate shunt (GO:0006098)2.40940299
172vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39240392
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.36800085
174regulation of granulocyte differentiation (GO:0030852)2.36592090
175negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35844724
176regulation of leukocyte degranulation (GO:0043300)2.35788890
177actin nucleation (GO:0045010)2.35534010
178pinocytosis (GO:0006907)2.34226019
179semaphorin-plexin signaling pathway (GO:0071526)2.33982429
180positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32282944
181response to laminar fluid shear stress (GO:0034616)2.31724532
182positive regulation of myotube differentiation (GO:0010831)2.30301571
183regulation of mast cell degranulation (GO:0043304)2.29135367
184macrophage activation involved in immune response (GO:0002281)2.28804888
185cell-substrate adherens junction assembly (GO:0007045)2.28650287
186focal adhesion assembly (GO:0048041)2.28650287
187negative regulation of B cell apoptotic process (GO:0002903)2.28304002
188negative T cell selection (GO:0043383)2.28192175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.28427709
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23100119
3E2F7_22180533_ChIP-Seq_HELA_Human3.04524431
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.97033371
5VDR_21846776_ChIP-Seq_THP-1_Human2.94473442
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87014502
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80046189
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66787600
9MYC_22102868_ChIP-Seq_BL_Human2.59529270
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53454034
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.53360070
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.39295612
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35200083
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.33085939
15XRN2_22483619_ChIP-Seq_HELA_Human2.29090134
16* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27016253
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.25010446
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23954014
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20930216
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19518101
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12726745
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10952701
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.10083049
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07806188
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07471306
26SRY_22984422_ChIP-ChIP_TESTIS_Rat2.03933384
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.03623989
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01925941
29CIITA_25753668_ChIP-Seq_RAJI_Human2.01243177
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95274756
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93906352
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92063991
33RACK7_27058665_Chip-Seq_MCF-7_Human1.90969658
34* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87824424
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85780538
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85618397
37* VDR_23849224_ChIP-Seq_CD4+_Human1.83913003
38DCP1A_22483619_ChIP-Seq_HELA_Human1.83445783
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81419232
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76950015
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74716712
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74128758
43GABP_19822575_ChIP-Seq_HepG2_Human1.69787126
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.68905409
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66472791
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64756826
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63435499
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.62168904
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61262402
50FOXP3_21729870_ChIP-Seq_TREG_Human1.60315049
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60103149
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59735326
53* SRF_21415370_ChIP-Seq_HL-1_Mouse1.57695370
54VDR_24763502_ChIP-Seq_THP-1_Human1.56482315
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55963694
56KDM2B_26808549_Chip-Seq_K562_Human1.51554590
57ZNF263_19887448_ChIP-Seq_K562_Human1.49736860
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.49672181
59* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49378983
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.49189536
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48889393
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46409660
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44780441
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44298414
65SMC4_20622854_ChIP-Seq_HELA_Human1.43909662
66BCOR_27268052_Chip-Seq_Bcells_Human1.43458777
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42658553
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41500507
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40882203
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.40270208
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40221815
72TTF2_22483619_ChIP-Seq_HELA_Human1.40130252
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.40123955
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39734470
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39646604
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38970871
77* UTX_26944678_Chip-Seq_JUKART_Human1.38197234
78* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37889021
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37160741
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.34567471
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.33575792
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33365911
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32557265
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.32251074
85NCOR1_26117541_ChIP-Seq_K562_Human1.31321973
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29901725
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29535914
88* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27269721
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26949998
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26585138
91MYC_18940864_ChIP-ChIP_HL60_Human1.26210826
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26059409
93LXR_22292898_ChIP-Seq_THP-1_Human1.25476973
94* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24968923
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24754871
96BCL6_27268052_Chip-Seq_Bcells_Human1.24486067
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23688033
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.23539066
99* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22868178
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22313367
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21829195
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21789839
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20753726
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20720055
105CREB1_26743006_Chip-Seq_LNCaP_Human1.19841457
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19792460
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19610605
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.19459046
109P68_20966046_ChIP-Seq_HELA_Human1.18967432
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18779887
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18377963
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.17872723
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.17033974
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15477404
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15411115
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14689596
117* SA1_27219007_Chip-Seq_Bcells_Human1.14018104
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13561608
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12927877
120* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12863162
121* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12795307
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12302086
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12295052
124TP53_22127205_ChIP-Seq_IMR90_Human1.11777146
125PHF8_20622854_ChIP-Seq_HELA_Human1.11687134
126CTCF_27219007_Chip-Seq_Bcells_Human1.11194214
127* KDM5A_27292631_Chip-Seq_BREAST_Human1.11171418
128E2F1_21310950_ChIP-Seq_MCF-7_Human1.10764528
129E2F1_20622854_ChIP-Seq_HELA_Human1.10116296
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09627674
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09333860
132SCL_19346495_ChIP-Seq_HPC-7_Human1.09182520
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09079792
134* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08770337
135TCF7_22412390_ChIP-Seq_EML_Mouse1.08697331
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08298763
137* ETS1_21867929_ChIP-Seq_TH2_Mouse1.06148528
138MAF_26560356_Chip-Seq_TH2_Human1.05219343
139* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04714078
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04570875
141SPI1_23127762_ChIP-Seq_K562_Human1.03968334
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03579751
143P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03379722
144CTCF_21964334_Chip-Seq_Bcells_Human1.03341667
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03192864
146* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03123260
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02808512
148* SPI1_23547873_ChIP-Seq_NB4_Human1.02768123
149STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00996881
150HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00683908
151MAF_26560356_Chip-Seq_TH1_Human1.00523067
152* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00429637
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.99902795
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98857205
155KDM2B_26808549_Chip-Seq_DND41_Human0.98567886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.90197616
2MP0005451_abnormal_body_composition3.85221724
3MP0002837_dystrophic_cardiac_calcinosis3.65967834
4MP0003436_decreased_susceptibility_to3.55030054
5MP0003283_abnormal_digestive_organ3.46103636
6MP0003646_muscle_fatigue3.44917635
7MP0008007_abnormal_cellular_replicative3.39327504
8MP0002822_catalepsy3.34802914
9MP0005058_abnormal_lysosome_morphology3.14693563
10MP0003705_abnormal_hypodermis_morpholog2.87991676
11MP0010030_abnormal_orbit_morphology2.87193343
12MP0004043_abnormal_pH_regulation2.79989526
13MP0004142_abnormal_muscle_tone2.63366392
14MP0006035_abnormal_mitochondrial_morpho2.62313848
15MP0005377_hearing/vestibular/ear_phenot2.59627201
16MP0003878_abnormal_ear_physiology2.59627201
17MP0003303_peritoneal_inflammation2.57744211
18MP0000013_abnormal_adipose_tissue2.53221253
19MP0004858_abnormal_nervous_system2.42119993
20MP0000751_myopathy2.37964764
21MP0003111_abnormal_nucleus_morphology2.30730336
22MP0004145_abnormal_muscle_electrophysio2.27474433
23MP0001348_abnormal_lacrimal_gland2.27135609
24MP0009840_abnormal_foam_cell2.24579643
25MP0004957_abnormal_blastocyst_morpholog2.17363386
26MP0001835_abnormal_antigen_presentation2.08247010
27MP0004133_heterotaxia2.07980751
28MP0004947_skin_inflammation2.05868713
29MP0002909_abnormal_adrenal_gland2.04344326
30MP0008058_abnormal_DNA_repair2.01673647
31MP0003786_premature_aging2.01292307
32MP0005025_abnormal_response_to2.00060851
33MP0005000_abnormal_immune_tolerance1.98547964
34MP0001800_abnormal_humoral_immune1.96454296
35MP0001188_hyperpigmentation1.95269315
36MP0006036_abnormal_mitochondrial_physio1.94022305
37MP0001849_ear_inflammation1.93879951
38MP0003191_abnormal_cellular_cholesterol1.90596766
39MP0001790_abnormal_immune_system1.89729474
40MP0005387_immune_system_phenotype1.89729474
41MP0002419_abnormal_innate_immunity1.87584612
42MP0009333_abnormal_splenocyte_physiolog1.86997417
43MP0002249_abnormal_larynx_morphology1.83659206
44MP0008260_abnormal_autophagy1.82778174
45MP0004036_abnormal_muscle_relaxation1.82754367
46MP0002723_abnormal_immune_serum1.82396980
47MP0002420_abnormal_adaptive_immunity1.82099735
48MP0001819_abnormal_immune_cell1.79081404
49MP0000749_muscle_degeneration1.76473368
50MP0002452_abnormal_antigen_presenting1.76058421
51MP0005367_renal/urinary_system_phenotyp1.74823875
52MP0000516_abnormal_urinary_system1.74823875
53MP0004084_abnormal_cardiac_muscle1.68981907
54MP0001873_stomach_inflammation1.68469269
55MP0000015_abnormal_ear_pigmentation1.68286062
56MP0004215_abnormal_myocardial_fiber1.65093967
57MP0000858_altered_metastatic_potential1.60514846
58MP0003693_abnormal_embryo_hatching1.59792100
59MP0003172_abnormal_lysosome_physiology1.57625802
60MP0005076_abnormal_cell_differentiation1.54119510
61MP0002405_respiratory_system_inflammati1.52995673
62* MP0010094_abnormal_chromosome_stability1.52376041
63MP0000716_abnormal_immune_system1.50208352
64MP0005174_abnormal_tail_pigmentation1.49953203
65MP0004185_abnormal_adipocyte_glucose1.46318618
66MP0005464_abnormal_platelet_physiology1.45433249
67MP0000678_abnormal_parathyroid_gland1.42369545
68MP0002148_abnormal_hypersensitivity_rea1.42012222
69MP0010155_abnormal_intestine_physiology1.39808450
70MP0000750_abnormal_muscle_regeneration1.38882214
71MP0003077_abnormal_cell_cycle1.38063687
72MP0001533_abnormal_skeleton_physiology1.37703191
73MP0005083_abnormal_biliary_tract1.37001092
74MP0002269_muscular_atrophy1.35705053
75MP0003763_abnormal_thymus_physiology1.35050533
76MP0002877_abnormal_melanocyte_morpholog1.31955190
77MP0009278_abnormal_bone_marrow1.28550329
78MP0005375_adipose_tissue_phenotype1.28059295
79MP0008770_decreased_survivor_rate1.27960171
80MP0002396_abnormal_hematopoietic_system1.26580764
81MP0008569_lethality_at_weaning1.25979102
82MP0003300_gastrointestinal_ulcer1.25508263
83MP0009785_altered_susceptibility_to1.24320165
84MP0001270_distended_abdomen1.23991495
85MP0005666_abnormal_adipose_tissue1.22493290
86MP0005409_darkened_coat_color1.19262582
87MP0003724_increased_susceptibility_to1.17736432
88MP0005623_abnormal_meninges_morphology1.16460450
89MP0002998_abnormal_bone_remodeling1.12225263
90MP0000689_abnormal_spleen_morphology1.12028674
91MP0003866_abnormal_defecation1.08622737
92MP0000703_abnormal_thymus_morphology1.08455952
93MP0005257_abnormal_intraocular_pressure1.08452012
94MP0000733_abnormal_muscle_development1.07933063
95MP0001845_abnormal_inflammatory_respons1.07322803
96MP0002932_abnormal_joint_morphology1.05152824
97MP0003828_pulmonary_edema1.05100743
98MP0005220_abnormal_exocrine_pancreas1.03242190
99MP0005330_cardiomyopathy1.03132297
100MP0002398_abnormal_bone_marrow1.02043108
101MP0008469_abnormal_protein_level1.01094415
102MP0000465_gastrointestinal_hemorrhage1.00658167
103MP0005397_hematopoietic_system_phenotyp1.00278086
104MP0001545_abnormal_hematopoietic_system1.00278086
105MP0000358_abnormal_cell_content/1.00186993
106MP0003943_abnormal_hepatobiliary_system0.99592917
107MP0004484_altered_response_of0.97887436
108MP0000343_altered_response_to0.97548476
109MP0001944_abnormal_pancreas_morphology0.97255494
110MP0001663_abnormal_digestive_system0.97087312
111MP0002722_abnormal_immune_system0.96272289
112MP0003329_amyloid_beta_deposits0.95827593
113MP0003183_abnormal_peptide_metabolism0.95452611
114MP0004087_abnormal_muscle_fiber0.95111906
115MP0001502_abnormal_circadian_rhythm0.94963274
116MP0000685_abnormal_immune_system0.94936286
117MP0006072_abnormal_retinal_apoptosis0.94295946
118MP0006082_CNS_inflammation0.94166272
119MP0000003_abnormal_adipose_tissue0.93692700
120MP0001986_abnormal_taste_sensitivity0.91815790
121MP0002106_abnormal_muscle_physiology0.90617124
122MP0003091_abnormal_cell_migration0.90170629
123MP0004147_increased_porphyrin_level0.89964813
124MP0000681_abnormal_thyroid_gland0.89861953
125MP0000490_abnormal_crypts_of0.89423852
126MP0005310_abnormal_salivary_gland0.88883909
127MP0004510_myositis0.88221503
128MP0002132_abnormal_respiratory_system0.85454443
129MP0003075_altered_response_to0.85291351
130* MP0000350_abnormal_cell_proliferation0.84505603
131MP0004233_abnormal_muscle_weight0.84074396
132MP0008932_abnormal_embryonic_tissue0.83290561
133MP0001929_abnormal_gametogenesis0.83277729
134MP0004808_abnormal_hematopoietic_stem0.82378002
135MP0005671_abnormal_response_to0.82100937
136MP0003453_abnormal_keratinocyte_physiol0.78843103
137MP0008438_abnormal_cutaneous_collagen0.78469144
138MP0001853_heart_inflammation0.76714318
139MP0001919_abnormal_reproductive_system0.76516497
140MP0005381_digestive/alimentary_phenotyp0.75528474
141MP0000313_abnormal_cell_death0.75489646
142MP0002933_joint_inflammation0.75291446
143MP0003566_abnormal_cell_adhesion0.74975341
144MP0001529_abnormal_vocalization0.73986066
145MP0000759_abnormal_skeletal_muscle0.73866926
146MP0002638_abnormal_pupillary_reflex0.73859447
147MP0004085_abnormal_heartbeat0.73336382
148MP0005390_skeleton_phenotype0.73196520
149MP0001730_embryonic_growth_arrest0.72934875
150MP0000049_abnormal_middle_ear0.72872095
151MP0005084_abnormal_gallbladder_morpholo0.72306062
152MP0005410_abnormal_fertilization0.71432762
153MP0008877_abnormal_DNA_methylation0.70785713
154MP0002177_abnormal_outer_ear0.70782433
155* MP0002019_abnormal_tumor_incidence0.69682138
156MP0002080_prenatal_lethality0.68578929
157MP0005501_abnormal_skin_physiology0.68217824
158MP0000747_muscle_weakness0.67677154
159MP0001905_abnormal_dopamine_level0.67327535
160MP0009764_decreased_sensitivity_to0.67286451
161MP0008874_decreased_physiological_sensi0.67210046
162* MP0002083_premature_death0.66982183
163MP0003699_abnormal_female_reproductive0.65575225
164MP0002184_abnormal_innervation0.65340243
165MP0002429_abnormal_blood_cell0.64808976
166MP0002210_abnormal_sex_determination0.64761366
167MP0005075_abnormal_melanosome_morpholog0.63985283
168MP0002089_abnormal_postnatal_growth/wei0.63833855
169MP0003137_abnormal_impulse_conducting0.62829092
170MP0006054_spinal_hemorrhage0.62428144

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.68531462
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35030791
3Broad face (HP:0000283)5.26685031
4Hepatocellular necrosis (HP:0001404)4.62105078
5Abnormality of the aortic arch (HP:0012303)4.42268429
6Failure to thrive in infancy (HP:0001531)4.37558729
7Hyperacusis (HP:0010780)3.98601571
8Hepatic necrosis (HP:0002605)3.97053594
9Prominent metopic ridge (HP:0005487)3.82704726
10Large eyes (HP:0001090)3.79602575
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.70017307
12Bilateral microphthalmos (HP:0007633)3.64643990
13Mitochondrial inheritance (HP:0001427)3.62842832
14Morphological abnormality of the middle ear (HP:0008609)3.51680717
15Cellulitis (HP:0100658)3.43623155
16Abnormality of the metopic suture (HP:0005556)3.43343153
17Increased hepatocellular lipid droplets (HP:0006565)3.40229353
18Broad palm (HP:0001169)3.33931705
19Lipid accumulation in hepatocytes (HP:0006561)3.23557414
20Agammaglobulinemia (HP:0004432)3.08933586
21Self-mutilation (HP:0000742)3.02839936
22Thin bony cortex (HP:0002753)2.99663138
23Increased CSF lactate (HP:0002490)2.95793718
24Achilles tendon contracture (HP:0001771)2.95291828
25Eczematoid dermatitis (HP:0000976)2.94434421
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89893377
27Macrocytic anemia (HP:0001972)2.89695259
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.86674209
29Exertional dyspnea (HP:0002875)2.84643450
30Increased IgM level (HP:0003496)2.84568043
31Mesangial abnormality (HP:0001966)2.78727872
32Increased intramyocellular lipid droplets (HP:0012240)2.78139228
33Vertebral compression fractures (HP:0002953)2.77832387
34Limb dystonia (HP:0002451)2.77642360
35Respiratory difficulties (HP:0002880)2.77397562
36Difficulty climbing stairs (HP:0003551)2.77010382
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74965124
38Abnormality of alanine metabolism (HP:0010916)2.74965124
39Hyperalaninemia (HP:0003348)2.74965124
40Hypertensive crisis (HP:0100735)2.74900377
41Colitis (HP:0002583)2.64643887
42Distal lower limb amyotrophy (HP:0008944)2.62943417
43Increased muscle lipid content (HP:0009058)2.61123833
44Delayed CNS myelination (HP:0002188)2.59232203
45Fatigue (HP:0012378)2.55825597
46Obstructive lung disease (HP:0006536)2.55053432
47Chronic obstructive pulmonary disease (HP:0006510)2.55053432
48Abnormality of macrophages (HP:0004311)2.54666386
49Dislocated radial head (HP:0003083)2.52820151
50Long palpebral fissure (HP:0000637)2.52422390
51Thoracic kyphosis (HP:0002942)2.50769022
52Slender long bone (HP:0003100)2.49647248
53Abnormality of the Achilles tendon (HP:0005109)2.48379799
54Increased serum lactate (HP:0002151)2.47832294
55Broad alveolar ridges (HP:0000187)2.45983830
56Mediastinal lymphadenopathy (HP:0100721)2.44124368
57Pallor (HP:0000980)2.42992398
58Broad metatarsal (HP:0001783)2.42256400
59Dysostosis multiplex (HP:0000943)2.39522686
60Abnormality of the radial head (HP:0003995)2.37329395
61Abnormal mitochondria in muscle tissue (HP:0008316)2.35918076
62Increased connective tissue (HP:0009025)2.35553524
63Acute necrotizing encephalopathy (HP:0006965)2.33183585
64Recurrent fungal infections (HP:0002841)2.30317297
65Thrombocytosis (HP:0001894)2.29576498
66Meningitis (HP:0001287)2.29368224
67Generalized hypotonia (HP:0001290)2.26163482
68Abnormality of glycolipid metabolism (HP:0010969)2.25576290
69Abnormality of liposaccharide metabolism (HP:0010968)2.25576290
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.25576290
71Increased IgE level (HP:0003212)2.25441869
72Hemorrhage of the eye (HP:0011885)2.23242815
73Emotional lability (HP:0000712)2.22708475
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22358155
75Overlapping toe (HP:0001845)2.22320829
76Protrusio acetabuli (HP:0003179)2.19480165
77J-shaped sella turcica (HP:0002680)2.18733323
78Granulocytopenia (HP:0001913)2.15760991
79Severe visual impairment (HP:0001141)2.14973319
80Acute encephalopathy (HP:0006846)2.14352743
81Flared metaphyses (HP:0003015)2.13609653
82Reticulocytopenia (HP:0001896)2.12470331
83Myopathic facies (HP:0002058)2.11484013
84Recurrent viral infections (HP:0004429)2.10271749
85Abnormal protein N-linked glycosylation (HP:0012347)2.08241923
86Abnormal protein glycosylation (HP:0012346)2.08241923
87Abnormal glycosylation (HP:0012345)2.08241923
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08241923
89Broad distal phalanx of finger (HP:0009836)2.08132152
90Distal upper limb amyotrophy (HP:0007149)2.07142935
91Upper limb amyotrophy (HP:0009129)2.07142935
92Mitral regurgitation (HP:0001653)2.06945512
93Redundant skin (HP:0001582)2.06344780
94Type I transferrin isoform profile (HP:0003642)2.06148618
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.06095625
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05528698
97Flexion contracture of toe (HP:0005830)2.04373001
98Joint contractures involving the joints of the feet (HP:0100492)2.04373001
99Anomalous pulmonary venous return (HP:0010772)2.03897272
100Lactic acidosis (HP:0003128)2.03820769
101Nasal polyposis (HP:0100582)2.03540401
102Gastrointestinal infarctions (HP:0005244)2.02683172
103Distal lower limb muscle weakness (HP:0009053)2.02571146
104Slow saccadic eye movements (HP:0000514)2.02304485
105Renal Fanconi syndrome (HP:0001994)2.01730335
106Asymmetric septal hypertrophy (HP:0001670)2.01363279
107Split foot (HP:0001839)2.01114772
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01009886
109Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01009886
110Disproportionate tall stature (HP:0001519)1.99574593
111Joint stiffness (HP:0001387)1.99509783
112Progressive muscle weakness (HP:0003323)1.99459490
113Chronic mucocutaneous candidiasis (HP:0002728)1.98751873
114Recurrent cutaneous fungal infections (HP:0011370)1.98751873
115Muscle stiffness (HP:0003552)1.98723055
116Flattened epiphyses (HP:0003071)1.98659584
117Hydroureter (HP:0000072)1.98626327
118Abnormality of the anterior horn cell (HP:0006802)1.97822322
119Degeneration of anterior horn cells (HP:0002398)1.97822322
120Panhypogammaglobulinemia (HP:0003139)1.97228671
121Exercise intolerance (HP:0003546)1.97221451
122Pointed chin (HP:0000307)1.96494565
123Vertebral arch anomaly (HP:0008438)1.95867778
124Visual hallucinations (HP:0002367)1.94281238
125Metaphyseal cupping (HP:0003021)1.93643655
126Inflammation of the large intestine (HP:0002037)1.92148752
127Adducted thumb (HP:0001181)1.91510376
128Hypoplasia of the radius (HP:0002984)1.90963369
129Radial bowing (HP:0002986)1.90836987
130Recurrent abscess formation (HP:0002722)1.90542440
131Abnormality of polysaccharide metabolism (HP:0011012)1.89338673
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89338673
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89338673
134Gastrointestinal stroma tumor (HP:0100723)1.89110479
135Deep palmar crease (HP:0006191)1.88949584
136Ragged-red muscle fibers (HP:0003200)1.88246430
137Abnormality of the peritoneum (HP:0002585)1.88092905
138Hepatosplenomegaly (HP:0001433)1.87903128
139Gliosis (HP:0002171)1.87204883
140Respiratory failure (HP:0002878)1.85476091
141Easy fatigability (HP:0003388)1.85217356
142Urinary glycosaminoglycan excretion (HP:0003541)1.84975498
143Mucopolysacchariduria (HP:0008155)1.84975498
144Hypoplasia of the thymus (HP:0000778)1.84521590
145Hypergammaglobulinemia (HP:0010702)1.84330440
146Recurrent bacterial skin infections (HP:0005406)1.84255370
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83677916
148Late onset (HP:0003584)1.82471905
149Increased cerebral lipofuscin (HP:0011813)1.81975110
150Reticulocytosis (HP:0001923)1.81739624
151Exercise-induced myalgia (HP:0003738)1.81303127
152Ulnar bowing (HP:0003031)1.80844210
153Cervical subluxation (HP:0003308)1.80499204
154Biconcave vertebral bodies (HP:0004586)1.80172750
155Emphysema (HP:0002097)1.79997512
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.78476504
157Aplasia/Hypoplasia of the thymus (HP:0010515)1.78251714
158Sudden death (HP:0001699)1.77792000
159Myositis (HP:0100614)1.77261580
160Flat acetabular roof (HP:0003180)1.76765465
161Gingivitis (HP:0000230)1.76156361
162Abnormality of B cell number (HP:0010975)1.76049538
163B lymphocytopenia (HP:0010976)1.76049538
164Elevated erythrocyte sedimentation rate (HP:0003565)1.75844163
165Cerebral aneurysm (HP:0004944)1.75748408
166Rhabdomyolysis (HP:0003201)1.75628253
167Growth hormone excess (HP:0000845)1.75433917
168Gastrointestinal inflammation (HP:0004386)1.74697650
169Interstitial pulmonary disease (HP:0006530)1.74270844
170Abnormality of the humeroradial joint (HP:0100744)1.74207945
171Flat capital femoral epiphysis (HP:0003370)1.74114161
172Abnormality of the pulmonary veins (HP:0011718)1.73860895
173Abnormality of chromosome segregation (HP:0002916)1.72754573
174Persistence of primary teeth (HP:0006335)1.71958444
175Truncus arteriosus (HP:0001660)1.71648997
176Seborrheic dermatitis (HP:0001051)1.71547228
177Abnormality of the fingertips (HP:0001211)1.71337248
178Hypertriglyceridemia (HP:0002155)1.70983559
179Insomnia (HP:0100785)1.70561324
180Abnormality of skeletal muscle fiber size (HP:0012084)1.69491586
181Spontaneous hematomas (HP:0007420)1.68455138
182Encephalitis (HP:0002383)1.67147031
183Increased variability in muscle fiber diameter (HP:0003557)1.66631681
184Cerebellar hypoplasia (HP:0001321)1.65154585
185Abnormality of the thoracic spine (HP:0100711)1.64074940
186Congenital malformation of the right heart (HP:0011723)1.63102320
187Double outlet right ventricle (HP:0001719)1.63102320
188Atrioventricular canal defect (HP:0006695)1.63012441
18911 pairs of ribs (HP:0000878)1.62904594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.75782388
2ERN13.54597171
3NME22.73847515
4TESK22.71589099
5KDR2.69949849
6PKN22.66278631
7MAP3K92.66154310
8BRAF2.57149948
9VRK12.46837788
10NEK22.44037415
11SIK12.40880417
12TRIB32.35671108
13TESK12.32392751
14BCKDK2.24604399
15IRAK32.23698390
16MST1R2.17492684
17SMG12.08074945
18MAP2K31.98474028
19MAP3K61.87467483
20PIM21.84549619
21TLK11.80578513
22FLT31.78045405
23STK161.76676155
24PDK31.75150862
25PDK41.75150862
26MAP3K121.70612476
27RPS6KA41.68994257
28ZAP701.52890245
29MAP3K131.51007296
30PIK3CA1.49549767
31OBSCN1.49506098
32TTN1.48554947
33MAP4K11.47863747
34TAOK11.45043707
35PASK1.42771604
36SCYL21.41710383
37PRKD21.35965188
38MARK21.35352092
39TAOK21.33912492
40EEF2K1.33387389
41PAK41.29051979
42CDK191.27565318
43DAPK31.25362025
44SIK21.22871831
45TNK21.22058677
46LRRK21.18267274
47MAP3K101.18110822
48AURKA1.17336459
49CDC71.13460620
50CDC42BPA1.07410377
51TGFBR21.05092272
52STK101.03535337
53KIT1.03198861
54MYLK1.02691726
55SRPK11.02629255
56MAP3K141.02046872
57MAP3K111.01039320
58DYRK31.00290021
59PDK20.97849667
60IRAK40.95140751
61ICK0.95105672
62TNIK0.92076439
63MAPK120.91621857
64RPS6KA20.91524785
65EPHB20.90592355
66JAK30.90057346
67MAP2K20.89858880
68AURKB0.88979346
69MAP3K10.88272645
70NME10.87724022
71MARK30.87149045
72ARAF0.83714635
73RIPK10.83421634
74MAP3K80.81674038
75FGFR40.81518776
76PDPK10.80882984
77CSK0.80761054
78CCNB10.80076789
79RPS6KC10.80001335
80RPS6KL10.80001335
81EPHA20.79397556
82WEE10.77070305
83CAMKK20.76895897
84CDK120.76894044
85ABL20.76287289
86MTOR0.75023371
87PRPF4B0.74765412
88EPHB10.74760440
89BLK0.74571886
90MUSK0.72986864
91TYK20.72022775
92BMX0.71377551
93BTK0.70558889
94PLK10.67180852
95RIPK40.66845210
96CAMKK10.66304266
97MAP3K30.65691314
98RPS6KA60.63717730
99LMTK20.63314569
100FES0.61096979
101MOS0.59934220
102MAP3K70.59730278
103KSR20.59049984
104CAMK2G0.58269387
105WNK40.58020529
106RPS6KA50.57844244
107HCK0.56222518
108PIK3CG0.55783479
109PRKD30.55470723
110MAP2K10.55367944
111MAP3K40.54465954
112PDK10.54156045
113PIM10.53683518
114PTK20.53556680
115TTK0.53480731
116GRK60.52668274
117TBK10.51066422
118ILK0.50830396
119RPS6KB20.50291008
120SYK0.50213070
121CAMK2D0.49256461
122MATK0.48781458
123CDK90.45923131
124NTRK30.45677313
125ATR0.45634699
126RAF10.45462296
127MAPK110.45140691
128DYRK1B0.44797552
129PTK2B0.44339434
130PTK60.43848652
131LIMK10.43244365
132ADRBK20.43213426
133LCK0.43056162
134CDK40.42494385
135IKBKB0.42372752
136CDK11A0.41706553
137RET0.40274409
138LYN0.38269774
139TIE10.38220550
140PRKD10.38151964
141CDK80.37495684
142PHKG20.35761943
143PHKG10.35761943
144CSF1R0.34751993
145CAMK2B0.34643051
146CHUK0.33928122
147PRKCH0.33345108
148MAPK40.32829724
149ITK0.32771587
150MAP2K40.32453998
151MKNK20.31654534
152PAK10.29587488

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.10915340
2Sulfur relay system_Homo sapiens_hsa041223.18801175
3Nucleotide excision repair_Homo sapiens_hsa034202.80794674
4DNA replication_Homo sapiens_hsa030302.75071841
5Parkinsons disease_Homo sapiens_hsa050122.67116480
6Mismatch repair_Homo sapiens_hsa034302.61847262
7Oxidative phosphorylation_Homo sapiens_hsa001902.54131033
8RNA polymerase_Homo sapiens_hsa030202.34360063
9Cardiac muscle contraction_Homo sapiens_hsa042602.26231726
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26166499
11Proteasome_Homo sapiens_hsa030502.06477817
12Huntingtons disease_Homo sapiens_hsa050162.05695247
13* Homologous recombination_Homo sapiens_hsa034401.99000199
14Osteoclast differentiation_Homo sapiens_hsa043801.92545977
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.86399011
16* Fanconi anemia pathway_Homo sapiens_hsa034601.83241767
17Leishmaniasis_Homo sapiens_hsa051401.78976558
18Spliceosome_Homo sapiens_hsa030401.78620633
19Notch signaling pathway_Homo sapiens_hsa043301.78609737
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78461496
21Alzheimers disease_Homo sapiens_hsa050101.77641020
22Non-homologous end-joining_Homo sapiens_hsa034501.75786346
23Pyrimidine metabolism_Homo sapiens_hsa002401.72743945
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72302795
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.62101810
26Base excision repair_Homo sapiens_hsa034101.60297153
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60100846
28Protein export_Homo sapiens_hsa030601.59346224
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53568514
30Primary immunodeficiency_Homo sapiens_hsa053401.51173178
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47176110
32Pancreatic cancer_Homo sapiens_hsa052121.44467402
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35028745
34Apoptosis_Homo sapiens_hsa042101.34027416
35RNA degradation_Homo sapiens_hsa030181.31374913
36Cell cycle_Homo sapiens_hsa041101.31046589
37Sulfur metabolism_Homo sapiens_hsa009201.30441066
38Toxoplasmosis_Homo sapiens_hsa051451.26472754
39Viral myocarditis_Homo sapiens_hsa054161.24408806
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.24101861
41Other glycan degradation_Homo sapiens_hsa005111.23795724
42TNF signaling pathway_Homo sapiens_hsa046681.22578160
43N-Glycan biosynthesis_Homo sapiens_hsa005101.22481825
44Allograft rejection_Homo sapiens_hsa053301.22239627
45Herpes simplex infection_Homo sapiens_hsa051681.21198661
46Purine metabolism_Homo sapiens_hsa002301.20892750
47Influenza A_Homo sapiens_hsa051641.20789931
48Hepatitis B_Homo sapiens_hsa051611.20459598
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17272322
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.16366136
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.15853167
52Tuberculosis_Homo sapiens_hsa051521.14500249
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12522615
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06972331
55Nicotine addiction_Homo sapiens_hsa050331.06863396
56Hepatitis C_Homo sapiens_hsa051601.06828182
57Salmonella infection_Homo sapiens_hsa051321.04965948
58Graft-versus-host disease_Homo sapiens_hsa053321.03821705
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02006340
60RNA transport_Homo sapiens_hsa030131.01674925
61Lysosome_Homo sapiens_hsa041421.01303615
62B cell receptor signaling pathway_Homo sapiens_hsa046621.01272319
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.01078947
64Autoimmune thyroid disease_Homo sapiens_hsa053201.00917988
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99933217
66Measles_Homo sapiens_hsa051620.98626134
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97762397
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.96114923
69Systemic lupus erythematosus_Homo sapiens_hsa053220.95393449
70mTOR signaling pathway_Homo sapiens_hsa041500.94828839
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94620485
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94255429
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93280815
74Endocytosis_Homo sapiens_hsa041440.91772495
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89024657
76Malaria_Homo sapiens_hsa051440.88909871
77Alcoholism_Homo sapiens_hsa050340.87389377
78Fructose and mannose metabolism_Homo sapiens_hsa000510.85967961
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.84748056
80ErbB signaling pathway_Homo sapiens_hsa040120.80269759
81Carbon metabolism_Homo sapiens_hsa012000.79996878
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79248013
83Prolactin signaling pathway_Homo sapiens_hsa049170.77248644
84Small cell lung cancer_Homo sapiens_hsa052220.77126897
85Insulin signaling pathway_Homo sapiens_hsa049100.75828950
86Prion diseases_Homo sapiens_hsa050200.75552059
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.75353672
88Biosynthesis of amino acids_Homo sapiens_hsa012300.73654955
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73535693
90Epstein-Barr virus infection_Homo sapiens_hsa051690.72895375
91Hematopoietic cell lineage_Homo sapiens_hsa046400.71907098
92Pyruvate metabolism_Homo sapiens_hsa006200.71827686
93Insulin resistance_Homo sapiens_hsa049310.70331835
94Chemokine signaling pathway_Homo sapiens_hsa040620.70252892
95Pentose phosphate pathway_Homo sapiens_hsa000300.70233179
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69404203
97p53 signaling pathway_Homo sapiens_hsa041150.69403609
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69309710
99HTLV-I infection_Homo sapiens_hsa051660.68675085
100Oocyte meiosis_Homo sapiens_hsa041140.68359538
101VEGF signaling pathway_Homo sapiens_hsa043700.67888891
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67663145
103Endometrial cancer_Homo sapiens_hsa052130.66467475
104Renal cell carcinoma_Homo sapiens_hsa052110.66076811
105Antigen processing and presentation_Homo sapiens_hsa046120.66046621
106Phagosome_Homo sapiens_hsa041450.65933416
107Thyroid cancer_Homo sapiens_hsa052160.64503704
108Insulin secretion_Homo sapiens_hsa049110.63695310
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.62440482
110Dilated cardiomyopathy_Homo sapiens_hsa054140.61762556
111Folate biosynthesis_Homo sapiens_hsa007900.61295695
112T cell receptor signaling pathway_Homo sapiens_hsa046600.60917675
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.60588231
114Inositol phosphate metabolism_Homo sapiens_hsa005620.60469830
115Galactose metabolism_Homo sapiens_hsa000520.60196017
116Pertussis_Homo sapiens_hsa051330.60026083
117Amphetamine addiction_Homo sapiens_hsa050310.59725329
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58961866
119Glioma_Homo sapiens_hsa052140.58827294
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58576881
121AMPK signaling pathway_Homo sapiens_hsa041520.57580465
122Long-term potentiation_Homo sapiens_hsa047200.55611567
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55475763
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55441615
125Focal adhesion_Homo sapiens_hsa045100.54795865
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54624947
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54045777
128Shigellosis_Homo sapiens_hsa051310.53173895
129MAPK signaling pathway_Homo sapiens_hsa040100.53009155
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52543773
131Type I diabetes mellitus_Homo sapiens_hsa049400.51736221
132Colorectal cancer_Homo sapiens_hsa052100.51346979
133Platelet activation_Homo sapiens_hsa046110.51157934
134Bladder cancer_Homo sapiens_hsa052190.51108959
135Cocaine addiction_Homo sapiens_hsa050300.49901319
136Staphylococcus aureus infection_Homo sapiens_hsa051500.49109237
137GnRH signaling pathway_Homo sapiens_hsa049120.49061435
138Chronic myeloid leukemia_Homo sapiens_hsa052200.49042944
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48903843
140Amoebiasis_Homo sapiens_hsa051460.48457629
141Basal transcription factors_Homo sapiens_hsa030220.48066257
142Choline metabolism in cancer_Homo sapiens_hsa052310.48041042
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.47997426
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46268775
145Synaptic vesicle cycle_Homo sapiens_hsa047210.45853102
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45001264
147Acute myeloid leukemia_Homo sapiens_hsa052210.43858635
148Morphine addiction_Homo sapiens_hsa050320.42813612
149Hedgehog signaling pathway_Homo sapiens_hsa043400.42445475
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42424655
151Calcium signaling pathway_Homo sapiens_hsa040200.41143280
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40216043
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39997241
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38694176
155Long-term depression_Homo sapiens_hsa047300.38120358
156Non-small cell lung cancer_Homo sapiens_hsa052230.36803803
157Dopaminergic synapse_Homo sapiens_hsa047280.35822062
158Maturity onset diabetes of the young_Homo sapiens_hsa049500.33844014
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33320741
160Circadian entrainment_Homo sapiens_hsa047130.32508776
161Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32333300
162Metabolic pathways_Homo sapiens_hsa011000.32143123
163Viral carcinogenesis_Homo sapiens_hsa052030.31575657
164Oxytocin signaling pathway_Homo sapiens_hsa049210.31543822
165Glucagon signaling pathway_Homo sapiens_hsa049220.30792202
166Salivary secretion_Homo sapiens_hsa049700.28543950
167Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28458302

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