MUSTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1creatine metabolic process (GO:0006600)7.31401967
2muscle filament sliding (GO:0030049)6.68092105
3actin-myosin filament sliding (GO:0033275)6.68092105
4actin-mediated cell contraction (GO:0070252)5.94525081
5regulation of skeletal muscle contraction (GO:0014819)5.83740636
6keratan sulfate catabolic process (GO:0042340)5.71170767
7response to inactivity (GO:0014854)5.61363819
8glycogen catabolic process (GO:0005980)5.34309322
9atrioventricular valve morphogenesis (GO:0003181)5.16840896
10glucan catabolic process (GO:0009251)5.00469823
11glucan biosynthetic process (GO:0009250)4.98947299
12glycogen biosynthetic process (GO:0005978)4.98947299
13cardiac muscle contraction (GO:0060048)4.97827527
14negative regulation of smooth muscle cell differentiation (GO:0051151)4.86851974
15cellular polysaccharide catabolic process (GO:0044247)4.68539783
16skeletal muscle tissue development (GO:0007519)4.67708866
17regulation of actin filament-based movement (GO:1903115)4.65423921
18skeletal muscle fiber development (GO:0048741)4.61991497
19skeletal muscle contraction (GO:0003009)4.59705287
20plasma membrane repair (GO:0001778)4.56074979
21skeletal muscle tissue regeneration (GO:0043403)4.52783595
22actin filament-based movement (GO:0030048)4.50019551
23collagen fibril organization (GO:0030199)4.46781153
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.41489457
25cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.33820811
26cartilage condensation (GO:0001502)4.33584880
27cell aggregation (GO:0098743)4.33584880
28neuronal action potential propagation (GO:0019227)4.24502961
29polysaccharide catabolic process (GO:0000272)4.22372015
30muscle cell fate commitment (GO:0042693)4.15898582
31NADH metabolic process (GO:0006734)4.13897304
32sarcoplasmic reticulum calcium ion transport (GO:0070296)4.08038467
33fructose metabolic process (GO:0006000)4.07771567
34muscle cell cellular homeostasis (GO:0046716)4.07401113
35myotube cell development (GO:0014904)4.04482943
36otic vesicle formation (GO:0030916)4.01478906
37negative regulation of muscle contraction (GO:0045932)3.96042095
382-oxoglutarate metabolic process (GO:0006103)3.84579276
39cGMP-mediated signaling (GO:0019934)3.81204032
40glycogen metabolic process (GO:0005977)3.81157412
41regulation of striated muscle contraction (GO:0006942)3.79990435
42response to activity (GO:0014823)3.79603281
43sarcomere organization (GO:0045214)3.78780713
44cellular glucan metabolic process (GO:0006073)3.72994102
45glucan metabolic process (GO:0044042)3.72994102
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.72672820
47adult heart development (GO:0007512)3.72022420
48muscle tissue morphogenesis (GO:0060415)3.71148943
49positive regulation of myotube differentiation (GO:0010831)3.64839365
50chondrocyte development (GO:0002063)3.64448221
51muscle hypertrophy (GO:0014896)3.63835400
52myotube differentiation (GO:0014902)3.62710947
53skin morphogenesis (GO:0043589)3.61830215
54gluconeogenesis (GO:0006094)3.61432279
55heart valve morphogenesis (GO:0003179)3.60651109
56relaxation of muscle (GO:0090075)3.60316053
57myoblast fusion (GO:0007520)3.58402475
58muscle organ morphogenesis (GO:0048644)3.53076726
59ubiquinone biosynthetic process (GO:0006744)3.53026780
60cardiac muscle tissue morphogenesis (GO:0055008)3.51230291
61negative regulation of heart growth (GO:0061117)3.50772868
62negative regulation of cardiac muscle tissue growth (GO:0055022)3.50772868
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50311298
64negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.49297911
65negative regulation of calcium ion transmembrane transport (GO:1903170)3.49297911
66positive regulation of extracellular matrix organization (GO:1903055)3.42644917
67muscle contraction (GO:0006936)3.41310016
68tricarboxylic acid cycle (GO:0006099)3.39383049
69regulation of calcium ion transmembrane transporter activity (GO:1901019)3.36698800
70regulation of calcium ion transmembrane transport (GO:1903169)3.36698800
71regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.36388096
72neuromuscular synaptic transmission (GO:0007274)3.35661659
73notochord development (GO:0030903)3.32962819
74negative regulation of potassium ion transmembrane transport (GO:1901380)3.31827190
75oxidative phosphorylation (GO:0006119)3.31586265
76muscle cell development (GO:0055001)3.31318985
77myofibril assembly (GO:0030239)3.28819665
78striated muscle tissue development (GO:0014706)3.28560621
79hypotonic response (GO:0006971)3.28269003
80respiratory electron transport chain (GO:0022904)3.27021454
81endocardial cushion morphogenesis (GO:0003203)3.26051013
82heart contraction (GO:0060047)3.25842138
83heart process (GO:0003015)3.25842138
84protein heterotrimerization (GO:0070208)3.25732974
85cardiac muscle adaptation (GO:0014887)3.25706689
86cardiac muscle hypertrophy in response to stress (GO:0014898)3.25706689
87muscle hypertrophy in response to stress (GO:0003299)3.25706689
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25044525
89cell migration involved in heart development (GO:0060973)3.24910388
90regulation of myoblast differentiation (GO:0045661)3.24242285
91basement membrane organization (GO:0071711)3.24060492
92replacement ossification (GO:0036075)3.22915052
93endochondral ossification (GO:0001958)3.22915052
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20806739
95cardiac muscle cell development (GO:0055013)3.20776049
96muscle adaptation (GO:0043500)3.20591359
97collagen metabolic process (GO:0032963)3.20068923
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.19884669
99cellular carbohydrate catabolic process (GO:0044275)3.18708550
100IMP metabolic process (GO:0046040)3.17818160
101electron transport chain (GO:0022900)3.17790070
102hexose biosynthetic process (GO:0019319)3.17440240
103collagen catabolic process (GO:0030574)3.17104294
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16999562
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16872721
106atrial septum morphogenesis (GO:0060413)3.15167183
107skeletal muscle adaptation (GO:0043501)3.14987637
108muscle system process (GO:0003012)3.14158274
109negative regulation of complement activation (GO:0045916)3.14132254
110coronary vasculature morphogenesis (GO:0060977)3.13326556
111positive regulation of endothelial cell apoptotic process (GO:2000353)3.10693827
112positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08601038
113positive regulation of astrocyte differentiation (GO:0048711)3.07313490
114cardiac epithelial to mesenchymal transition (GO:0060317)3.05482715
115regulation of cardioblast proliferation (GO:0003264)3.02919033
116regulation of secondary heart field cardioblast proliferation (GO:0003266)3.02919033
117negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.02780677
118multicellular organismal macromolecule metabolic process (GO:0044259)3.00652817
119muscle fiber development (GO:0048747)2.96655110
120mesenchymal cell development (GO:0014031)2.96561732
121heart valve formation (GO:0003188)2.95660646
122multicellular organismal catabolic process (GO:0044243)2.92836354
123striated muscle contraction (GO:0006941)2.88261058
124multicellular organismal metabolic process (GO:0044236)2.88089951
125positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.87667826
126short-term memory (GO:0007614)2.86870759
127regulation of cell communication by electrical coupling (GO:0010649)2.86834576
128cardiac right ventricle morphogenesis (GO:0003215)2.85004758
129regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.82040146
130regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81292124
131response to muscle activity (GO:0014850)2.81010450
132endodermal cell differentiation (GO:0035987)2.80198575
133actomyosin structure organization (GO:0031032)2.79909350
134cardiac myofibril assembly (GO:0055003)2.78935104
135retina vasculature morphogenesis in camera-type eye (GO:0061299)2.78739202
136response to gravity (GO:0009629)2.78430645
137striated muscle adaptation (GO:0014888)2.77533417
138heart trabecula formation (GO:0060347)2.76145216
139regulation of p38MAPK cascade (GO:1900744)2.75977806
140regulation of smooth muscle cell differentiation (GO:0051150)2.75488819
141peptidyl-proline hydroxylation (GO:0019511)2.71347078
142response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.68944331
143positive regulation of cartilage development (GO:0061036)2.68393596
144striated muscle hypertrophy (GO:0014897)2.66712151
145endothelial cell morphogenesis (GO:0001886)2.66473604
146regulation of relaxation of muscle (GO:1901077)2.66337445
147cardiac muscle hypertrophy (GO:0003300)2.65626953
148keratan sulfate biosynthetic process (GO:0018146)2.65195024
149chondrocyte proliferation (GO:0035988)2.65122956
150chondroitin sulfate biosynthetic process (GO:0030206)2.65064724
151vascular endothelial growth factor signaling pathway (GO:0038084)2.64845607
152endothelium development (GO:0003158)2.64780351
153muscle organ development (GO:0007517)2.63864282
154regulation of muscle hypertrophy (GO:0014743)2.63229954
155negative regulation of protein activation cascade (GO:2000258)2.63133186
156positive regulation of p38MAPK cascade (GO:1900745)2.62791450
157regulation of integrin-mediated signaling pathway (GO:2001044)2.61934771
158muscle structure development (GO:0061061)2.61712412
159protein hydroxylation (GO:0018126)2.59801951
160endocardial cushion development (GO:0003197)2.58479012
161negative regulation of striated muscle cell apoptotic process (GO:0010664)2.57579938
162regulation of plasminogen activation (GO:0010755)2.55734729
163extracellular matrix disassembly (GO:0022617)2.55686747
164regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55205259
165striated muscle cell development (GO:0055002)2.50781684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.88747939
2EZH2_22144423_ChIP-Seq_EOC_Human6.06181221
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.57258618
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.47016511
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.52417291
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.94917249
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.39307845
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14920179
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.79260149
10CLOCK_20551151_ChIP-Seq_293T_Human2.74493696
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.65533966
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.47617030
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.42124427
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40620090
15CJUN_26792858_Chip-Seq_BT549_Human2.35173091
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.32732610
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.32709508
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31339096
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30349438
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28491587
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.25593179
22AR_21572438_ChIP-Seq_LNCaP_Human2.25244946
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.24665938
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24293457
25EP300_21415370_ChIP-Seq_HL-1_Mouse2.18026994
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16915310
27BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.14053977
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.09679549
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06345998
30ESR1_20079471_ChIP-ChIP_T-47D_Human2.02292182
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87137463
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.85483203
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.85483203
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75896567
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75049117
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.73783912
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.73783912
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.73456754
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66749095
40CTCF_27219007_Chip-Seq_Bcells_Human1.65663534
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.61827486
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60905156
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.59863254
44VDR_22108803_ChIP-Seq_LS180_Human1.57999515
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.56627919
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.49735991
47TP53_18474530_ChIP-ChIP_U2OS_Human1.47754745
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45196869
49ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44946792
50SOX2_20726797_ChIP-Seq_SW620_Human1.40663867
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40137930
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37694742
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.37238736
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36534939
55JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34091723
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32373652
57GATA4_21415370_ChIP-Seq_HL-1_Mouse1.32157631
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31463093
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31463093
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30060387
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30060387
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28932416
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27166437
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26659414
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26477134
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26237145
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26208612
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25131855
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.23755724
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23363452
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23202496
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22675388
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22325406
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19674183
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19465304
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18933203
77STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18668157
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14068541
79BRD4_25478319_ChIP-Seq_HGPS_Human1.12296208
80DROSHA_22980978_ChIP-Seq_HELA_Human1.12200569
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11334670
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.10929061
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10716904
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09542248
85RXR_22108803_ChIP-Seq_LS180_Human1.08938961
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08114736
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07373504
88SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06458025
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05855827
90MYC_27129775_Chip-Seq_CORNEA_Mouse1.04395736
91IGF1R_20145208_ChIP-Seq_DFB_Human1.04323074
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.04090766
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.04021464
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03647581
95SA1_27219007_Chip-Seq_Bcells_Human1.03331608
96TP53_16413492_ChIP-PET_HCT116_Human1.02048043
97OCT4_20526341_ChIP-Seq_ESCs_Human1.02017086
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99871371
99CSB_26484114_Chip-Seq_FIBROBLAST_Human0.99305997
100BCAT_22108803_ChIP-Seq_LS180_Human0.99098858
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97315298
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97244673
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97222741
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96700827
105SOX2_19829295_ChIP-Seq_ESCs_Human0.96689685
106NANOG_19829295_ChIP-Seq_ESCs_Human0.96689685
107LXR_22158963_ChIP-Seq_LIVER_Mouse0.96543348
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.95663559
109STAT1_20625510_ChIP-Seq_HELA_Human0.95337527
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95330931
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93658044
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93118626
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92863931
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92452710
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92155302
116CRX_20693478_ChIP-Seq_RETINA_Mouse0.91890813
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.91443370
118SPI1_20517297_ChIP-Seq_HL60_Human0.91154908
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.90680304
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.90099976
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88051519
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.88008559
123EZH2_27294783_Chip-Seq_ESCs_Mouse0.87896045
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87289148
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87199881
126* RXR_22158963_ChIP-Seq_LIVER_Mouse0.87198053
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86770567
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86393011
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86006631
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.85762666
131SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85754449
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85502862
133CBP_21632823_ChIP-Seq_H3396_Human0.85396160
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85196427
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84818244
136JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84480371
137RACK7_27058665_Chip-Seq_MCF-7_Human0.83966449
138* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83839165
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83359070
140* HTT_18923047_ChIP-ChIP_STHdh_Human0.82809206
141CBP_20019798_ChIP-Seq_JUKART_Human0.82691729
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82691729
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81874910
144NANOG_20526341_ChIP-Seq_ESCs_Human0.81745069
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81146388
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80549405
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80163044
148RNF2_27304074_Chip-Seq_NSC_Mouse0.80092048
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79665356
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79290802
151FUS_26573619_Chip-Seq_HEK293_Human0.78800718
152EGR1_19032775_ChIP-ChIP_M12_Human0.78624761
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78423800
154CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78007334
155ATF3_27146783_Chip-Seq_COLON_Human0.77639511
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77151629
157GATA6_21074721_ChIP-Seq_CACO-2_Human0.77095275
158TP63_23658742_ChIP-Seq_EP156T_Human0.76867323
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76723708
160ER_23166858_ChIP-Seq_MCF-7_Human0.75778104
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.75689070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration4.08907295
2MP0000751_myopathy4.00115480
3MP0008438_abnormal_cutaneous_collagen3.59807475
4MP0009384_cardiac_valve_regurgitation3.37873401
5MP0005503_abnormal_tendon_morphology3.34502938
6MP0004145_abnormal_muscle_electrophysio3.09289648
7MP0005451_abnormal_body_composition3.04910716
8MP0005275_abnormal_skin_tensile3.02356739
9MP0003279_aneurysm2.98792358
10MP0002837_dystrophic_cardiac_calcinosis2.83106937
11MP0003646_muscle_fatigue2.62040955
12MP0004036_abnormal_muscle_relaxation2.51430155
13MP0001542_abnormal_bone_strength2.49063414
14MP0000747_muscle_weakness2.48694085
15MP0004272_abnormal_basement_membrane2.39867866
16MP0000750_abnormal_muscle_regeneration2.39177129
17MP0005620_abnormal_muscle_contractility2.32628423
18MP0003950_abnormal_plasma_membrane2.25101603
19MP0004084_abnormal_cardiac_muscle2.24671586
20MP0009250_abnormal_appendicular_skeleto2.16037563
21MP0004087_abnormal_muscle_fiber2.13785728
22MP0004134_abnormal_chest_morphology2.11316302
23MP0002108_abnormal_muscle_morphology2.10450450
24MP0002106_abnormal_muscle_physiology2.09960927
25MP0003705_abnormal_hypodermis_morpholog2.07491797
26MP0005330_cardiomyopathy2.01656168
27MP0000759_abnormal_skeletal_muscle2.01104947
28MP0005369_muscle_phenotype1.97773047
29MP0006036_abnormal_mitochondrial_physio1.94956455
30MP0002933_joint_inflammation1.90582859
31MP0002282_abnormal_trachea_morphology1.90126701
32MP0002269_muscular_atrophy1.89661233
33MP0000013_abnormal_adipose_tissue1.79157247
34MP0001958_emphysema1.77742452
35MP0000163_abnormal_cartilage_morphology1.74280114
36MP0005623_abnormal_meninges_morphology1.69278115
37MP0006054_spinal_hemorrhage1.65409960
38MP0002972_abnormal_cardiac_muscle1.62918248
39MP0005508_abnormal_skeleton_morphology1.62672985
40MP0000733_abnormal_muscle_development1.61559864
41MP0004484_altered_response_of1.61074143
42MP0003566_abnormal_cell_adhesion1.59954765
43MP0008775_abnormal_heart_ventricle1.56808620
44MP0004233_abnormal_muscle_weight1.54709845
45MP0001299_abnormal_eye_distance/1.47411660
46MP0000767_abnormal_smooth_muscle1.46990074
47MP0004215_abnormal_myocardial_fiber1.46492643
48MP0000343_altered_response_to1.39789879
49MP0002896_abnormal_bone_mineralization1.39570149
50MP0003941_abnormal_skin_development1.37892835
51MP0004270_analgesia1.37125188
52MP0004185_abnormal_adipocyte_glucose1.36892331
53MP0002115_abnormal_skeleton_extremities1.33857472
54MP0004130_abnormal_muscle_cell1.32371324
55MP0005266_abnormal_metabolism1.29814553
56MP0010368_abnormal_lymphatic_system1.26919162
57MP0005023_abnormal_wound_healing1.26555823
58MP0003136_yellow_coat_color1.26210421
59MP0000762_abnormal_tongue_morphology1.21361305
60MP0001879_abnormal_lymphatic_vessel1.20466353
61MP0003091_abnormal_cell_migration1.19620816
62MP0003283_abnormal_digestive_organ1.17711308
63MP0001544_abnormal_cardiovascular_syste1.16803585
64MP0005385_cardiovascular_system_phenoty1.16803585
65MP0005390_skeleton_phenotype1.16501156
66MP0002127_abnormal_cardiovascular_syste1.14008660
67MP0002089_abnormal_postnatal_growth/wei1.13963752
68MP0002332_abnormal_exercise_endurance1.13490802
69MP0006138_congestive_heart_failure1.13411599
70MP0002822_catalepsy1.10450517
71MP0005164_abnormal_response_to1.10118390
72MP0009780_abnormal_chondrocyte_physiolo1.09526642
73MP0001533_abnormal_skeleton_physiology1.08952749
74MP0002113_abnormal_skeleton_development1.08431871
75MP0003385_abnormal_body_wall1.07595608
76MP0002295_abnormal_pulmonary_circulatio1.07345619
77MP0005595_abnormal_vascular_smooth1.07328980
78MP0010630_abnormal_cardiac_muscle1.04329127
79MP0002009_preneoplasia1.00444790
80MP0001346_abnormal_lacrimal_gland1.00280771
81MP0002971_abnormal_brown_adipose1.00204377
82MP0005666_abnormal_adipose_tissue0.99982571
83MP0002060_abnormal_skin_morphology0.96625209
84MP0004085_abnormal_heartbeat0.96042208
85MP0005165_increased_susceptibility_to0.95511253
86MP0003011_delayed_dark_adaptation0.94840240
87MP0004510_myositis0.94416290
88MP0005375_adipose_tissue_phenotype0.94384193
89MP0000230_abnormal_systemic_arterial0.92141968
90MP0003221_abnormal_cardiomyocyte_apopto0.90260401
91MP0005670_abnormal_white_adipose0.88544129
92MP0002128_abnormal_blood_circulation0.86206526
93MP0001243_abnormal_dermal_layer0.85528521
94MP0002909_abnormal_adrenal_gland0.83383084
95MP0003724_increased_susceptibility_to0.83336323
96MP0009379_abnormal_foot_pigmentation0.83085867
97MP0003045_fibrosis0.81391789
98MP0004142_abnormal_muscle_tone0.79767865
99MP0004147_increased_porphyrin_level0.79714668
100MP0000249_abnormal_blood_vessel0.78346306
101MP0000003_abnormal_adipose_tissue0.78317555
102MP0000372_irregular_coat_pigmentation0.77456375
103MP0003828_pulmonary_edema0.77256825
104MP0003795_abnormal_bone_structure0.76332565
105MP0000049_abnormal_middle_ear0.75525823
106MP0005423_abnormal_somatic_nervous0.74284186
107MP0002998_abnormal_bone_remodeling0.73406017
108MP0003879_abnormal_hair_cell0.72271269
109MP0003137_abnormal_impulse_conducting0.72194566
110MP0002109_abnormal_limb_morphology0.70251602
111MP0002638_abnormal_pupillary_reflex0.67309893
112MP0002234_abnormal_pharynx_morphology0.66336407
113MP0001614_abnormal_blood_vessel0.65140664
114MP0010030_abnormal_orbit_morphology0.63993812
115MP0004883_abnormal_blood_vessel0.63610560
116MP0002796_impaired_skin_barrier0.60979081
117MP0005388_respiratory_system_phenotype0.58534264
118MP0002133_abnormal_respiratory_system0.58534264
119MP0000266_abnormal_heart_morphology0.58400325
120MP0002734_abnormal_mechanical_nocicepti0.49883900
121MP0001661_extended_life_span0.48753295
122MP0001529_abnormal_vocalization0.48130541
123MP0002078_abnormal_glucose_homeostasis0.46427369
124MP0006276_abnormal_autonomic_nervous0.45793796
125MP0005376_homeostasis/metabolism_phenot0.44059941
126MP0005167_abnormal_blood-brain_barrier0.42936246
127MP0002938_white_spotting0.42923925
128MP0008569_lethality_at_weaning0.40627000
129MP0004043_abnormal_pH_regulation0.40478200
130MP0005083_abnormal_biliary_tract0.40079855
131MP0005187_abnormal_penis_morphology0.36168659
132MP0005535_abnormal_body_temperature0.33826873
133MP0002114_abnormal_axial_skeleton0.33723785
134MP0002249_abnormal_larynx_morphology0.31425226
135MP0005452_abnormal_adipose_tissue0.30975835
136MP0009672_abnormal_birth_weight0.30938709
137MP0005584_abnormal_enzyme/coenzyme_acti0.29700042
138MP0003315_abnormal_perineum_morphology0.29419653
139MP0000026_abnormal_inner_ear0.28286704
140MP0002066_abnormal_motor_capabilities/c0.27438915
141MP0003806_abnormal_nucleotide_metabolis0.27313337
142MP0000534_abnormal_ureter_morphology0.26741524
143MP0001943_abnormal_respiration0.26322046
144MP0005332_abnormal_amino_acid0.26120835
145MP0003948_abnormal_gas_homeostasis0.25841785
146MP0003938_abnormal_ear_development0.24861468
147MP0002067_abnormal_sensory_capabilities0.24815218
148MP0008789_abnormal_olfactory_epithelium0.24722979
149MP0003567_abnormal_fetal_cardiomyocyte0.22848456

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)5.81465410
2Muscle fiber inclusion bodies (HP:0100299)5.59291979
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.57045049
4Nemaline bodies (HP:0003798)5.25164408
5Hypoplastic ischia (HP:0003175)5.11640756
6Epiphyseal dysplasia (HP:0002656)4.88803783
7Rhabdomyolysis (HP:0003201)4.66965677
8Distal arthrogryposis (HP:0005684)4.66506448
9Abnormality of the ischium (HP:0003174)4.53876860
10Ulnar deviation of the wrist (HP:0003049)4.50599404
11Rimmed vacuoles (HP:0003805)4.41740905
12Round ear (HP:0100830)4.33825294
13Centrally nucleated skeletal muscle fibers (HP:0003687)4.27058391
14Muscle fiber splitting (HP:0003555)4.23283640
15Vitreoretinal degeneration (HP:0000655)4.22114112
16Irregular epiphyses (HP:0010582)4.18512907
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.02868249
18Cupped ribs (HP:0000887)4.00852128
19Abnormality of the left ventricular outflow tract (HP:0011103)3.99855945
20Subaortic stenosis (HP:0001682)3.99855945
21Increased connective tissue (HP:0009025)3.64899781
22Exercise-induced muscle cramps (HP:0003710)3.63515070
23Hyporeflexia of lower limbs (HP:0002600)3.62986842
24Exercise-induced myalgia (HP:0003738)3.62608027
25Myopathic facies (HP:0002058)3.56788096
26Metaphyseal cupping (HP:0003021)3.45409534
27Metaphyseal dysplasia (HP:0100255)3.34899434
28Absent phalangeal crease (HP:0006109)3.32596215
29Muscle hypertrophy of the lower extremities (HP:0008968)3.32069092
30Calf muscle hypertrophy (HP:0008981)3.29054275
31Abnormality of the calf musculature (HP:0001430)3.28655124
32Aortic aneurysm (HP:0004942)3.24014151
33Calcaneovalgus deformity (HP:0001848)3.22336919
34Areflexia of lower limbs (HP:0002522)3.22332289
35Asymmetric septal hypertrophy (HP:0001670)3.19390927
36Premature rupture of membranes (HP:0001788)3.14952641
37EMG: myopathic abnormalities (HP:0003458)3.11436904
38Deformed tarsal bones (HP:0008119)3.07882237
39Abnormal tarsal ossification (HP:0008369)3.06150735
40Abnormality of skeletal muscle fiber size (HP:0012084)3.05711840
41Spinal rigidity (HP:0003306)3.01983383
42Increased variability in muscle fiber diameter (HP:0003557)2.94997574
43Abnormality of the calcaneus (HP:0008364)2.94430486
44EMG: neuropathic changes (HP:0003445)2.92014619
45Neonatal short-limb short stature (HP:0008921)2.90588872
46Hip contracture (HP:0003273)2.90336094
47Flat capital femoral epiphysis (HP:0003370)2.89534211
48Waddling gait (HP:0002515)2.86565287
49Difficulty running (HP:0009046)2.84753516
50Protrusio acetabuli (HP:0003179)2.82646310
51Generalized muscle weakness (HP:0003324)2.80389753
52Flat acetabular roof (HP:0003180)2.80135894
53Right ventricular cardiomyopathy (HP:0011663)2.71558580
54Aortic dissection (HP:0002647)2.71546717
55Slender build (HP:0001533)2.69451925
56Mild short stature (HP:0003502)2.68525923
57Abnormal finger flexion creases (HP:0006143)2.68243031
58Neck muscle weakness (HP:0000467)2.67237056
59Genu varum (HP:0002970)2.63529787
60Weak cry (HP:0001612)2.59922437
61Mildly elevated creatine phosphokinase (HP:0008180)2.59810155
62Bundle branch block (HP:0011710)2.59180602
63Cervical subluxation (HP:0003308)2.57027398
64Limited hip movement (HP:0008800)2.51358497
65Small epiphyses (HP:0010585)2.50529668
66Abnormal foot bone ossification (HP:0010675)2.48247832
67Osteoarthritis (HP:0002758)2.46688175
68Coxa vara (HP:0002812)2.45422986
69Abnormality of the vertebral endplates (HP:0005106)2.44274493
70Bulbar palsy (HP:0001283)2.44274396
71Aplasia of the musculature (HP:0100854)2.42633576
72Arthropathy (HP:0003040)2.41901364
73Long clavicles (HP:0000890)2.41580545
74Scapular winging (HP:0003691)2.40734417
75Dilated cardiomyopathy (HP:0001644)2.40347805
76Distal lower limb muscle weakness (HP:0009053)2.37681490
77Difficulty climbing stairs (HP:0003551)2.37086258
78Fatigable weakness (HP:0003473)2.34801416
79Abnormality of the neuromuscular junction (HP:0003398)2.34801416
80Myotonia (HP:0002486)2.34180994
81Abnormality of femoral epiphyses (HP:0006499)2.31137229
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.31137229
83Mesomelia (HP:0003027)2.30496140
84Progressive muscle weakness (HP:0003323)2.30481893
85Irregular vertebral endplates (HP:0003301)2.26420143
86Malignant hyperthermia (HP:0002047)2.26350089
87Ventricular tachycardia (HP:0004756)2.26242012
88Thin ribs (HP:0000883)2.26051541
89Muscle stiffness (HP:0003552)2.24464164
90Absent frontal sinuses (HP:0002688)2.21750006
91Ankle contracture (HP:0006466)2.19662173
92Limb-girdle muscle atrophy (HP:0003797)2.17895979
93Exercise intolerance (HP:0003546)2.15952094
94Abnormal vertebral ossification (HP:0100569)2.14177780
95Follicular hyperkeratosis (HP:0007502)2.12213935
96Gowers sign (HP:0003391)2.11739424
97Abnormality of the proximal phalanges of the hand (HP:0009834)2.11024976
98Hyperkalemia (HP:0002153)2.09726683
99Ovoid vertebral bodies (HP:0003300)2.08187536
100Abnormality of the pubic bones (HP:0003172)2.08043896
101Proximal amyotrophy (HP:0007126)2.06564222
102Short hallux (HP:0010109)2.05381547
103Protuberant abdomen (HP:0001538)2.04266905
104Delayed epiphyseal ossification (HP:0002663)2.02175187
105Sudden death (HP:0001699)2.00593688
106Lipoatrophy (HP:0100578)1.99357309
107Abnormality of the epiphysis of the femoral head (HP:0010574)1.97439757
108Fetal akinesia sequence (HP:0001989)1.97228734
109Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95832367
110Popliteal pterygium (HP:0009756)1.95798819
111Flattened epiphyses (HP:0003071)1.93875021
112Platyspondyly (HP:0000926)1.91717006
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.90237643
114Abnormality of the foot musculature (HP:0001436)1.89667066
115Muscular dystrophy (HP:0003560)1.88137784
116Increased intramyocellular lipid droplets (HP:0012240)1.87138073
117Distal lower limb amyotrophy (HP:0008944)1.85756581
118Myoglobinuria (HP:0002913)1.83787209
119Aplasia/Hypoplasia of the hallux (HP:0008362)1.83317664
120Frequent falls (HP:0002359)1.81963370
121Enlarged epiphyses (HP:0010580)1.80495565
122Radial bowing (HP:0002986)1.78184810
123Abnormality of the shoulder girdle musculature (HP:0001435)1.78090115
124Type 2 muscle fiber atrophy (HP:0003554)1.77093838
125Facial diplegia (HP:0001349)1.76903747
126Paralysis (HP:0003470)1.76476875
127Abnormality of the femoral head (HP:0003368)1.76462660
128Abnormality of the hip-girdle musculature (HP:0001445)1.73398770
129Abnormality of the musculature of the pelvis (HP:0001469)1.73398770
130Acute necrotizing encephalopathy (HP:0006965)1.71585655
131Shoulder girdle muscle weakness (HP:0003547)1.71406312
132Lower limb amyotrophy (HP:0007210)1.70014124
133Heart block (HP:0012722)1.68465691
134Foot dorsiflexor weakness (HP:0009027)1.66934145
135Pelvic girdle muscle weakness (HP:0003749)1.65016922
136Nonprogressive disorder (HP:0003680)1.64646629
137Ulnar deviation of finger (HP:0009465)1.63889963
138Increased muscle lipid content (HP:0009058)1.61772754
139Abnormal mitochondria in muscle tissue (HP:0008316)1.60764706
140Limb-girdle muscle weakness (HP:0003325)1.60520743
141Muscle fiber atrophy (HP:0100295)1.59376441
142Amniotic constriction ring (HP:0009775)1.55336488
143Abnormality of placental membranes (HP:0011409)1.55336488
144Abnormal atrioventricular conduction (HP:0005150)1.53281588
145Hepatic necrosis (HP:0002605)1.48602521
146Metatarsus adductus (HP:0001840)1.45341103
147Ragged-red muscle fibers (HP:0003200)1.43275213
148Mitochondrial inheritance (HP:0001427)1.43208072
149Acute encephalopathy (HP:0006846)1.42603891
150Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.37417697
151Hepatocellular necrosis (HP:0001404)1.37296478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.94677332
2OBSCN4.49123429
3MYLK4.22657757
4MAP3K34.00972811
5PIK3CG3.82631199
6NME13.31728040
7DDR22.99879291
8DMPK2.79526726
9STK38L2.55066457
10PHKG22.35673466
11PHKG12.35673466
12STK242.26079729
13TRIB32.25359817
14PIK3CA1.86248114
15LIMK11.84906362
16ERN11.74591146
17PIM21.63829839
18PRKG21.57358320
19PAK21.55782127
20TRPM71.51907406
21MAP2K31.50331163
22EPHB21.49063089
23ZAK1.48281962
24MAPK121.47391038
25PDGFRA1.43592056
26ROCK11.29013949
27MAPKAPK31.26398461
28ERBB31.24046772
29EPHA31.22717190
30TAOK11.18412747
31NUAK11.17757213
32MUSK1.14471917
33PTK2B1.12871122
34ILK1.10629860
35TGFBR21.04961045
36TESK11.04336160
37DAPK31.02411142
38NEK11.00842130
39CCNB11.00132335
40PDK20.97926339
41PAK30.97421167
42MARK10.94765119
43FER0.94172655
44LATS10.93608734
45MAP2K10.92378532
46MOS0.92283171
47DYRK1B0.89248638
48TIE10.84771911
49MET0.82307620
50MST40.80565646
51EPHB10.79178018
52MAP2K60.78866956
53KIT0.77306426
54MAPK40.74908892
55BCKDK0.72871720
56VRK20.72723454
57CDC42BPA0.72221201
58LATS20.71154673
59MAP3K70.70143417
60MAPK150.64066184
61CDK190.63868941
62CAMK2G0.63684463
63GSK3A0.62011496
64PTK20.61539104
65RIPK10.61167404
66ABL20.61012847
67WNK40.60310685
68PKN10.60150357
69NEK90.58566662
70PINK10.58152891
71PDK40.56481625
72PDK30.56481625
73PRKD10.55290129
74MAPK70.54766617
75KSR10.54155151
76PRKAA20.53771239
77PRKG10.52068329
78MAPK130.50677337
79ROCK20.50280620
80CAMK10.49981514
81PDGFRB0.49096962
82TAOK20.49060169
83SIK10.48219064
84CAMK40.47556171
85FRK0.46179625
86MST1R0.44887966
87BMX0.41467510
88KDR0.41359567
89MAP3K110.40705766
90PNCK0.39665495
91STK30.39492550
92CAMK2B0.39087298
93MAP2K40.39043666
94MAP3K50.38262818
95ADRBK10.36538496
96EEF2K0.35144413
97LRRK20.33531420
98WNK10.33509669
99NME20.31711239
100AKT30.31105605
101TGFBR10.30979963
102PKN20.29374420
103RET0.28985709
104MAPKAPK50.28703703
105CDK60.28057433
106STK160.27995113
107SGK10.27839350
108VRK10.27707595
109PAK10.26801089
110INSR0.26603286
111RAF10.25475114
112CAMK2D0.25443055
113MAPK110.24903002
114KSR20.24596887
115BCR0.24561159
116RPS6KB10.24149625
117RPS6KA30.23822845
118PRKAA10.23631364
119PRKACA0.22616281
120CAMK2A0.22203979
121DAPK20.22026306
122MARK20.21684011
123STK110.21631144
124DYRK30.20964918
125NLK0.20878301
126PLK20.17350813
127AKT20.17193102
128PRKACB0.16673616
129PRKACG0.15922281
130SGK20.15110300
131MAP3K100.14944674
132GRK10.14606809
133RPS6KA10.14072583
134TNIK0.13911822
135MAPK100.13286889
136SGK30.12920378
137BMPR1B0.12282061
138FGFR20.10359815
139EPHA40.10329266
140TBK10.10244157
141WNK30.09073668
142PDPK10.07945939
143MARK30.06957472
144MAP3K40.06034424
145UHMK10.04167888
146RPS6KB20.04130474
147RPS6KL10.03577603
148RPS6KC10.03577603

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.27417488
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.82659261
3Dilated cardiomyopathy_Homo sapiens_hsa054143.66110961
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.47527492
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.40713201
6Parkinsons disease_Homo sapiens_hsa050123.20505454
7Focal adhesion_Homo sapiens_hsa045102.97346103
8Protein digestion and absorption_Homo sapiens_hsa049742.70050580
9Vascular smooth muscle contraction_Homo sapiens_hsa042702.09124200
10Cardiac muscle contraction_Homo sapiens_hsa042602.00219222
11Ribosome_Homo sapiens_hsa030102.00123782
12Huntingtons disease_Homo sapiens_hsa050161.86208252
13Starch and sucrose metabolism_Homo sapiens_hsa005001.77272255
14Proteoglycans in cancer_Homo sapiens_hsa052051.61240269
15Amoebiasis_Homo sapiens_hsa051461.60637538
16Pentose phosphate pathway_Homo sapiens_hsa000301.60255379
17Nitrogen metabolism_Homo sapiens_hsa009101.55917307
18Malaria_Homo sapiens_hsa051441.53507366
19Oxytocin signaling pathway_Homo sapiens_hsa049211.52579926
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50606603
21cGMP-PKG signaling pathway_Homo sapiens_hsa040221.50135258
22Fructose and mannose metabolism_Homo sapiens_hsa000511.44909932
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40173016
24TGF-beta signaling pathway_Homo sapiens_hsa043501.40110243
25Tight junction_Homo sapiens_hsa045301.28000594
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24787485
27Renin secretion_Homo sapiens_hsa049241.23638201
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21142579
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20739979
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18740792
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15970995
32Viral myocarditis_Homo sapiens_hsa054161.13474703
33Adherens junction_Homo sapiens_hsa045201.09094046
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09053620
35Platelet activation_Homo sapiens_hsa046111.08458629
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.08088253
37Phenylalanine metabolism_Homo sapiens_hsa003601.07717583
38Biosynthesis of amino acids_Homo sapiens_hsa012301.05779224
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04452641
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00178834
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99107007
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97454346
43Complement and coagulation cascades_Homo sapiens_hsa046100.95904256
44Ovarian steroidogenesis_Homo sapiens_hsa049130.95627025
45Sphingolipid metabolism_Homo sapiens_hsa006000.95463420
46Sulfur relay system_Homo sapiens_hsa041220.91812488
47Butanoate metabolism_Homo sapiens_hsa006500.90949416
48Arginine and proline metabolism_Homo sapiens_hsa003300.90799312
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87418865
50PPAR signaling pathway_Homo sapiens_hsa033200.86649963
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85987733
52Insulin resistance_Homo sapiens_hsa049310.82680018
53HIF-1 signaling pathway_Homo sapiens_hsa040660.77142292
54Calcium signaling pathway_Homo sapiens_hsa040200.76670244
55Gap junction_Homo sapiens_hsa045400.75918446
56Fatty acid elongation_Homo sapiens_hsa000620.75422003
57Arachidonic acid metabolism_Homo sapiens_hsa005900.72800742
58Hippo signaling pathway_Homo sapiens_hsa043900.71202129
59Insulin signaling pathway_Homo sapiens_hsa049100.70982484
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70073614
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69906598
62Renal cell carcinoma_Homo sapiens_hsa052110.66661751
63Fatty acid degradation_Homo sapiens_hsa000710.66646166
64Propanoate metabolism_Homo sapiens_hsa006400.65891354
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.65579568
66Bladder cancer_Homo sapiens_hsa052190.64776855
67Glucagon signaling pathway_Homo sapiens_hsa049220.63148147
68Galactose metabolism_Homo sapiens_hsa000520.62820026
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60861314
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59834418
71GnRH signaling pathway_Homo sapiens_hsa049120.59013886
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58466360
73Melanoma_Homo sapiens_hsa052180.58294328
74cAMP signaling pathway_Homo sapiens_hsa040240.58084529
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57847111
76MAPK signaling pathway_Homo sapiens_hsa040100.56856800
77Sulfur metabolism_Homo sapiens_hsa009200.56679218
78AMPK signaling pathway_Homo sapiens_hsa041520.56470741
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56304659
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55721949
81Circadian entrainment_Homo sapiens_hsa047130.55440095
82Histidine metabolism_Homo sapiens_hsa003400.54691228
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.54671496
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54464288
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54327739
86Peroxisome_Homo sapiens_hsa041460.53437794
87Insulin secretion_Homo sapiens_hsa049110.52922758
88Salivary secretion_Homo sapiens_hsa049700.51435492
89Phototransduction_Homo sapiens_hsa047440.50066121
90Ras signaling pathway_Homo sapiens_hsa040140.49502623
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49059558
92Rap1 signaling pathway_Homo sapiens_hsa040150.49033301
93Purine metabolism_Homo sapiens_hsa002300.48344321
94Melanogenesis_Homo sapiens_hsa049160.45598757
95Tyrosine metabolism_Homo sapiens_hsa003500.45255952
96beta-Alanine metabolism_Homo sapiens_hsa004100.43217715
97Caffeine metabolism_Homo sapiens_hsa002320.42875801
98Basal cell carcinoma_Homo sapiens_hsa052170.42753530
99Alzheimers disease_Homo sapiens_hsa050100.42409391
100Long-term potentiation_Homo sapiens_hsa047200.41840635
101Phagosome_Homo sapiens_hsa041450.41363945
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40274990
103Small cell lung cancer_Homo sapiens_hsa052220.40187363
104Amphetamine addiction_Homo sapiens_hsa050310.39757862
105Gastric acid secretion_Homo sapiens_hsa049710.39686749
106Fatty acid metabolism_Homo sapiens_hsa012120.39518754
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39471038
108Tryptophan metabolism_Homo sapiens_hsa003800.39453485
109Carbon metabolism_Homo sapiens_hsa012000.38691597
110Hedgehog signaling pathway_Homo sapiens_hsa043400.38658674
111Pathways in cancer_Homo sapiens_hsa052000.38537038
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37131239
113Arginine biosynthesis_Homo sapiens_hsa002200.37122024
114Salmonella infection_Homo sapiens_hsa051320.36289771
115Cholinergic synapse_Homo sapiens_hsa047250.36022560
116Circadian rhythm_Homo sapiens_hsa047100.35779948
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34503636
118Pyruvate metabolism_Homo sapiens_hsa006200.33898170
119Chemical carcinogenesis_Homo sapiens_hsa052040.33853431
120Thyroid hormone synthesis_Homo sapiens_hsa049180.33796794
121Bile secretion_Homo sapiens_hsa049760.32877594
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32428712
123Toxoplasmosis_Homo sapiens_hsa051450.32130557
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31961258
125Oxidative phosphorylation_Homo sapiens_hsa001900.31184547
126Rheumatoid arthritis_Homo sapiens_hsa053230.31083487
127Pertussis_Homo sapiens_hsa051330.31031049
128Metabolic pathways_Homo sapiens_hsa011000.31019348
129VEGF signaling pathway_Homo sapiens_hsa043700.30898781
130Long-term depression_Homo sapiens_hsa047300.30489164
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28958329
132Glutathione metabolism_Homo sapiens_hsa004800.26471129
133Olfactory transduction_Homo sapiens_hsa047400.25697670
134FoxO signaling pathway_Homo sapiens_hsa040680.24168642
135Linoleic acid metabolism_Homo sapiens_hsa005910.22054260
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21938272
137Wnt signaling pathway_Homo sapiens_hsa043100.21604298
138Folate biosynthesis_Homo sapiens_hsa007900.20374921
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.15020296
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14631052
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13011853
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.09456442
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07575256
144Dopaminergic synapse_Homo sapiens_hsa047280.07407011

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