MUT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.90764225
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.90764225
3L-phenylalanine metabolic process (GO:0006558)6.64559947
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.64559947
5aromatic amino acid family catabolic process (GO:0009074)6.11706753
6epoxygenase P450 pathway (GO:0019373)6.03835924
7exogenous drug catabolic process (GO:0042738)5.98711542
8omega-hydroxylase P450 pathway (GO:0097267)5.77279336
9glyoxylate metabolic process (GO:0046487)5.68655972
10alpha-linolenic acid metabolic process (GO:0036109)5.53308821
11lysine catabolic process (GO:0006554)5.50812025
12lysine metabolic process (GO:0006553)5.50812025
13cysteine metabolic process (GO:0006534)5.45254829
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.41698677
15tryptophan catabolic process (GO:0006569)5.40429384
16indole-containing compound catabolic process (GO:0042436)5.40429384
17indolalkylamine catabolic process (GO:0046218)5.40429384
18bile acid biosynthetic process (GO:0006699)5.36902821
19kynurenine metabolic process (GO:0070189)5.34682671
20sulfur amino acid catabolic process (GO:0000098)5.17759983
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.15588098
22tryptophan metabolic process (GO:0006568)5.12887863
23serine family amino acid catabolic process (GO:0009071)4.78895751
24urea metabolic process (GO:0019627)4.77235995
25urea cycle (GO:0000050)4.77235995
26amino-acid betaine metabolic process (GO:0006577)4.71799936
27ethanol metabolic process (GO:0006067)4.71774263
28complement activation, alternative pathway (GO:0006957)4.67284265
29cellular ketone body metabolic process (GO:0046950)4.58341187
30protein carboxylation (GO:0018214)4.57310249
31peptidyl-glutamic acid carboxylation (GO:0017187)4.57310249
32bile acid metabolic process (GO:0008206)4.55718897
33regulation of triglyceride catabolic process (GO:0010896)4.51576215
34negative regulation of fibrinolysis (GO:0051918)4.49257301
35high-density lipoprotein particle remodeling (GO:0034375)4.48998806
36regulation of protein activation cascade (GO:2000257)4.48998695
37alpha-amino acid catabolic process (GO:1901606)4.48355219
38aromatic amino acid family metabolic process (GO:0009072)4.44976696
39nitrogen cycle metabolic process (GO:0071941)4.41878564
40regulation of plasminogen activation (GO:0010755)4.40240289
41* homocysteine metabolic process (GO:0050667)4.34630589
42regulation of fibrinolysis (GO:0051917)4.34567651
43ethanol oxidation (GO:0006069)4.33431338
44* fatty acid beta-oxidation (GO:0006635)4.32106521
45* short-chain fatty acid metabolic process (GO:0046459)4.31296901
46acetyl-CoA metabolic process (GO:0006084)4.30918887
47tyrosine metabolic process (GO:0006570)4.29840224
48cellular amino acid catabolic process (GO:0009063)4.26278049
49fibrinolysis (GO:0042730)4.25020203
50regulation of complement activation (GO:0030449)4.23080001
51valine metabolic process (GO:0006573)4.22295554
52aspartate family amino acid catabolic process (GO:0009068)4.21510859
53* fatty acid oxidation (GO:0019395)4.16129654
54oxidative demethylation (GO:0070989)4.15392161
552-oxoglutarate metabolic process (GO:0006103)4.14945813
56triglyceride homeostasis (GO:0070328)4.14268103
57acylglycerol homeostasis (GO:0055090)4.14268103
58coenzyme catabolic process (GO:0009109)4.10529125
59* lipid oxidation (GO:0034440)4.09397791
60cellular modified amino acid catabolic process (GO:0042219)4.07844380
61glutamate metabolic process (GO:0006536)4.06027178
62S-adenosylmethionine metabolic process (GO:0046500)4.05471986
63serine family amino acid metabolic process (GO:0009069)4.04073660
64protein-lipid complex remodeling (GO:0034368)4.01714995
65macromolecular complex remodeling (GO:0034367)4.01714995
66plasma lipoprotein particle remodeling (GO:0034369)4.01714995
67* fatty acid catabolic process (GO:0009062)4.01694825
68branched-chain amino acid catabolic process (GO:0009083)4.00569342
69reverse cholesterol transport (GO:0043691)3.99517151
70blood coagulation, intrinsic pathway (GO:0007597)3.99278193
71ketone body metabolic process (GO:1902224)3.99191818
72plasma lipoprotein particle clearance (GO:0034381)3.97822116
73* monocarboxylic acid catabolic process (GO:0072329)3.95320347
74glycine metabolic process (GO:0006544)3.92894132
75* organic acid catabolic process (GO:0016054)3.92809734
76* carboxylic acid catabolic process (GO:0046395)3.92809734
77drug transmembrane transport (GO:0006855)3.92293276
78regulation of cholesterol esterification (GO:0010872)3.91191690
79cellular glucuronidation (GO:0052695)3.90679771
80phenylpropanoid metabolic process (GO:0009698)3.89173058
81indolalkylamine metabolic process (GO:0006586)3.83381899
82branched-chain amino acid metabolic process (GO:0009081)3.81698500
83benzene-containing compound metabolic process (GO:0042537)3.81191198
84carnitine metabolic process (GO:0009437)3.80601909
85dicarboxylic acid biosynthetic process (GO:0043650)3.79431729
86negative regulation of sterol transport (GO:0032372)3.77284986
87negative regulation of cholesterol transport (GO:0032375)3.77284986
88drug catabolic process (GO:0042737)3.75899481
89serine family amino acid biosynthetic process (GO:0009070)3.75389586
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.74028723
91amine catabolic process (GO:0009310)3.68396788
92cellular biogenic amine catabolic process (GO:0042402)3.68396788
93bile acid and bile salt transport (GO:0015721)3.66454832
94urate metabolic process (GO:0046415)3.64951350
95positive regulation of lipid catabolic process (GO:0050996)3.61483466
96biotin metabolic process (GO:0006768)3.61193805
97phospholipid efflux (GO:0033700)3.59792359
98fatty acid transmembrane transport (GO:1902001)3.57999703
99phospholipid homeostasis (GO:0055091)3.55732259
100aldehyde catabolic process (GO:0046185)3.55699483
101uronic acid metabolic process (GO:0006063)3.51183791
102glucuronate metabolic process (GO:0019585)3.51183791
103imidazole-containing compound metabolic process (GO:0052803)3.47215912
104heme transport (GO:0015886)3.46243689
105negative regulation of protein activation cascade (GO:2000258)3.45563930
106regulation of cholesterol metabolic process (GO:0090181)3.41405071
107polyketide metabolic process (GO:0030638)3.38902316
108doxorubicin metabolic process (GO:0044598)3.38902316
109daunorubicin metabolic process (GO:0044597)3.38902316
110cholesterol efflux (GO:0033344)3.38585590
111low-density lipoprotein particle remodeling (GO:0034374)3.38547853
112drug metabolic process (GO:0017144)3.38381804
113intestinal cholesterol absorption (GO:0030299)3.36765133
114cholesterol homeostasis (GO:0042632)3.36731424
115very-low-density lipoprotein particle assembly (GO:0034379)3.35287998
116positive regulation of fatty acid oxidation (GO:0046321)3.34089541
117cofactor catabolic process (GO:0051187)3.33584714
118aminoglycoside antibiotic metabolic process (GO:0030647)3.30686106
119peroxisome fission (GO:0016559)3.18463917
120COPII vesicle coating (GO:0048208)3.15247951
121negative regulation of lipase activity (GO:0060192)3.10181410
122protein activation cascade (GO:0072376)3.07790661
123negative regulation of hemostasis (GO:1900047)3.05718041
124negative regulation of blood coagulation (GO:0030195)3.05718041
125response to mercury ion (GO:0046689)3.04390318
126primary alcohol catabolic process (GO:0034310)3.03075886
127primary alcohol metabolic process (GO:0034308)3.00602979
128tricarboxylic acid cycle (GO:0006099)2.98786730
129positive regulation of triglyceride lipase activity (GO:0061365)2.89880257
130positive regulation of lipoprotein lipase activity (GO:0051006)2.89880257
131oxaloacetate metabolic process (GO:0006107)2.88241772
132pyrimidine nucleobase catabolic process (GO:0006208)2.88039495
133complement activation, classical pathway (GO:0006958)2.87667504
134negative regulation of complement activation (GO:0045916)2.87354393
135negative regulation of wound healing (GO:0061045)2.85098312
136negative regulation of coagulation (GO:0050819)2.81745616
137complement activation (GO:0006956)2.81200989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.71998416
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66425494
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.60920685
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.11166965
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.94909950
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.76906670
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.39143072
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83842007
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.82461809
10* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34233369
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.11437466
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54829345
13IGF1R_20145208_ChIP-Seq_DFB_Human2.20799429
14CLOCK_20551151_ChIP-Seq_293T_Human2.20427706
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10571163
16* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.10427571
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01992107
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9297291
19AR_21909140_ChIP-Seq_LNCAP_Human1.92430729
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86299751
21GBX2_23144817_ChIP-Seq_PC3_Human1.86082418
22GATA1_22025678_ChIP-Seq_K562_Human1.77217947
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70274981
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.65900560
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58440171
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56673893
27* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49676335
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49474772
29* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48781094
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42263960
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41199879
32* FUS_26573619_Chip-Seq_HEK293_Human1.40088700
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.39892476
34* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38564707
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37745616
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.37677670
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36569625
38HTT_18923047_ChIP-ChIP_STHdh_Human1.34870073
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33512184
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.33094543
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25459632
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23906446
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23670016
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19855456
45CBP_20019798_ChIP-Seq_JUKART_Human1.19855456
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19049520
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19001814
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.18528087
49* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15722667
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12922006
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.12158092
52* P300_19829295_ChIP-Seq_ESCs_Human1.11547134
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11390323
54EOMES_21245162_ChIP-Seq_HESCs_Human1.09437436
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08356208
56ZNF263_19887448_ChIP-Seq_K562_Human1.07512801
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06873640
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06550752
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.06369312
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04878589
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04830845
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.04480247
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04157355
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03318400
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02969417
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02016689
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01933766
68STAT3_23295773_ChIP-Seq_U87_Human1.00973965
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.00329081
70* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00211449
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00166794
72WT1_19549856_ChIP-ChIP_CCG9911_Human0.99362159
73GATA4_25053715_ChIP-Seq_YYC3_Human0.99340202
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97676912
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97676912
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.97631823
77AR_25329375_ChIP-Seq_VCAP_Human0.97409457
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96854083
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96786656
80P53_22387025_ChIP-Seq_ESCs_Mouse0.96492001
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96088764
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.94897842
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94654488
84ER_23166858_ChIP-Seq_MCF-7_Human0.94578430
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94308783
86TP53_18474530_ChIP-ChIP_U2OS_Human0.92984824
87SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92769822
88RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92709000
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92528541
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.92106846
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91850317
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.91251195
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.91053303
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90740653
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90685435
96TCF4_22108803_ChIP-Seq_LS180_Human0.90581711
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90239564
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89881535
99* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89858703
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89079598
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88982001
102PHF8_20622853_ChIP-Seq_HELA_Human0.88734848
103OCT4_18555785_Chip-Seq_ESCs_Mouse0.88039585
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87419763
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85632428
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.83134440
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80700705
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.75071194
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.75071194
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74639915
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71399922
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.71111950
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70871753
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70749581
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70053642
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.65969515
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65864086
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63637637
119CBP_21632823_ChIP-Seq_H3396_Human0.63420273
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.63333224
121AR_20517297_ChIP-Seq_VCAP_Human0.63207093
122CEBPB_22108803_ChIP-Seq_LS180_Human0.62452304
123EGR1_19032775_ChIP-ChIP_M12_Human0.62161286
124BCAT_22108803_ChIP-Seq_LS180_Human0.62100423
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61190674
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59955679
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59749027
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58109444
129* EP300_21415370_ChIP-Seq_HL-1_Mouse0.56474918
130SOX2_20726797_ChIP-Seq_SW620_Human0.55997344
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.54589832
132FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53977909
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.53196004
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.52872259
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.52743773
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.52427537
137GATA1_19941826_ChIP-Seq_K562_Human0.52084303
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.51480746
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51152881
140GATA6_25053715_ChIP-Seq_YYC3_Human0.50332614
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.50302469
142ERG_20517297_ChIP-Seq_VCAP_Human0.48971285
143KAP1_22055183_ChIP-Seq_ESCs_Mouse0.48704518
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48638475
145MYC_19915707_ChIP-ChIP_AK7_Human0.48292444
146GATA2_19941826_ChIP-Seq_K562_Human0.48109309
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48081505
148* CDX2_22108803_ChIP-Seq_LS180_Human0.47311490
149* PIAS1_25552417_ChIP-Seq_VCAP_Human0.47130192
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46752967
151TAF2_19829295_ChIP-Seq_ESCs_Human0.46478350
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.46148830
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43716310
154RARB_24833708_ChIP-Seq_LIVER_Mouse0.43586941
155IRF8_22096565_ChIP-ChIP_GC-B_Human0.43529895
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43350005
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.42402630
158TAF15_26573619_Chip-Seq_HEK293_Human0.41824977
159P53_21459846_ChIP-Seq_SAOS-2_Human0.41124830
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40667513
161TP63_23658742_ChIP-Seq_EP156T_Human0.40228225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.61125927
2MP0005360_urolithiasis7.07819019
3MP0005085_abnormal_gallbladder_physiolo5.82556785
4MP0005365_abnormal_bile_salt5.67895006
5MP0008875_abnormal_xenobiotic_pharmacok4.63566622
6MP0003806_abnormal_nucleotide_metabolis4.10105792
7MP0003252_abnormal_bile_duct3.64834472
8MP0010329_abnormal_lipoprotein_level3.41578552
9* MP0005332_abnormal_amino_acid3.09610727
10MP0003195_calcinosis3.06827115
11MP0005083_abnormal_biliary_tract2.74755097
12MP0009840_abnormal_foam_cell2.73096089
13MP0001666_abnormal_nutrient_absorption2.56567781
14MP0002118_abnormal_lipid_homeostasis2.22586812
15MP0004019_abnormal_vitamin_homeostasis2.22024901
16MP0003191_abnormal_cellular_cholesterol2.06724122
17* MP0000609_abnormal_liver_physiology2.02203477
18MP0002138_abnormal_hepatobiliary_system1.93576204
19MP0005319_abnormal_enzyme/_coenzyme1.87701442
20MP0005670_abnormal_white_adipose1.82828546
21MP0005584_abnormal_enzyme/coenzyme_acti1.71706882
22MP0002837_dystrophic_cardiac_calcinosis1.69779041
23MP0004130_abnormal_muscle_cell1.65526382
24MP0003868_abnormal_feces_composition1.63273984
25* MP0009643_abnormal_urine_homeostasis1.62404229
26MP0001764_abnormal_homeostasis1.61586387
27MP0003186_abnormal_redox_activity1.58924089
28MP0009780_abnormal_chondrocyte_physiolo1.44360722
29MP0005666_abnormal_adipose_tissue1.33688197
30* MP0006036_abnormal_mitochondrial_physio1.30270855
31MP0003705_abnormal_hypodermis_morpholog1.25234995
32MP0005451_abnormal_body_composition1.23515483
33MP0002909_abnormal_adrenal_gland1.21956518
34MP0010234_abnormal_vibrissa_follicle1.21500477
35MP0000751_myopathy1.21329564
36MP0009697_abnormal_copulation1.21165234
37MP0002971_abnormal_brown_adipose1.17787660
38MP0005636_abnormal_mineral_homeostasis1.15332326
39MP0005187_abnormal_penis_morphology1.13806366
40MP0003011_delayed_dark_adaptation1.09527689
41MP0001661_extended_life_span1.08690735
42MP0003656_abnormal_erythrocyte_physiolo1.06847789
43MP0000372_irregular_coat_pigmentation1.06676169
44* MP0000598_abnormal_liver_morphology1.05997923
45MP0005535_abnormal_body_temperature1.03190224
46MP0001756_abnormal_urination1.02827616
47MP0002078_abnormal_glucose_homeostasis1.01319311
48MP0005647_abnormal_sex_gland1.00889081
49MP0005367_renal/urinary_system_phenotyp1.00479485
50MP0000516_abnormal_urinary_system1.00479485
51MP0001984_abnormal_olfaction0.98345668
52MP0003718_maternal_effect0.97903946
53MP0010386_abnormal_urinary_bladder0.97629970
54MP0002876_abnormal_thyroid_physiology0.94645962
55MP0000604_amyloidosis0.94298621
56MP0003690_abnormal_glial_cell0.92610119
57MP0005334_abnormal_fat_pad0.91285613
58MP0003880_abnormal_central_pattern0.90940713
59MP0003941_abnormal_skin_development0.90373407
60* MP0004043_abnormal_pH_regulation0.89534999
61MP0004270_analgesia0.88658119
62MP0009764_decreased_sensitivity_to0.88569615
63MP0009763_increased_sensitivity_to0.87596714
64MP0004185_abnormal_adipocyte_glucose0.87338375
65MP0002638_abnormal_pupillary_reflex0.85672520
66* MP0009642_abnormal_blood_homeostasis0.85208617
67MP0010368_abnormal_lymphatic_system0.83188272
68MP0005408_hypopigmentation0.82492802
69MP0002090_abnormal_vision0.82320324
70MP0006035_abnormal_mitochondrial_morpho0.81676579
71MP0003950_abnormal_plasma_membrane0.79708766
72MP0005376_homeostasis/metabolism_phenot0.79036388
73MP0001188_hyperpigmentation0.77550445
74MP0002254_reproductive_system_inflammat0.76773173
75MP0005266_abnormal_metabolism0.76717038
76MP0005084_abnormal_gallbladder_morpholo0.76449954
77MP0005375_adipose_tissue_phenotype0.74904758
78MP0006276_abnormal_autonomic_nervous0.73933691
79MP0008469_abnormal_protein_level0.73886141
80MP0003122_maternal_imprinting0.73509048
81MP0004272_abnormal_basement_membrane0.72282829
82MP0005058_abnormal_lysosome_morphology0.71919571
83MP0005330_cardiomyopathy0.71420814
84MP0005646_abnormal_pituitary_gland0.70938269
85MP0002822_catalepsy0.69018222
86MP0003329_amyloid_beta_deposits0.68569320
87MP0009384_cardiac_valve_regurgitation0.68384626
88MP0003646_muscle_fatigue0.68024799
89* MP0002136_abnormal_kidney_physiology0.66705545
90MP0000230_abnormal_systemic_arterial0.65795682
91MP0005448_abnormal_energy_balance0.65450276
92MP0001765_abnormal_ion_homeostasis0.64099256
93MP0000749_muscle_degeneration0.62676908
94MP0009765_abnormal_xenobiotic_induced0.61971697
95MP0001529_abnormal_vocalization0.59251521
96MP0005409_darkened_coat_color0.59242349
97MP0004145_abnormal_muscle_electrophysio0.58204867
98MP0009115_abnormal_fat_cell0.57842607
99MP0008995_early_reproductive_senescence0.57370475
100MP0003567_abnormal_fetal_cardiomyocyte0.57301853
101* MP0005220_abnormal_exocrine_pancreas0.56558894
102MP0002269_muscular_atrophy0.56474925
103MP0004036_abnormal_muscle_relaxation0.54816129
104MP0000647_abnormal_sebaceous_gland0.54682014
105MP0000013_abnormal_adipose_tissue0.52096690
106MP0003953_abnormal_hormone_level0.52082726
107MP0004147_increased_porphyrin_level0.52051861
108* MP0002069_abnormal_eating/drinking_beha0.51525522
109MP0002970_abnormal_white_adipose0.49797652
110MP0008872_abnormal_physiological_respon0.49165570
111MP0004085_abnormal_heartbeat0.48831659
112MP0003890_abnormal_embryonic-extraembry0.48081264
113MP0005551_abnormal_eye_electrophysiolog0.47953067
114MP0005248_abnormal_Harderian_gland0.47184011
115MP0003638_abnormal_response/metabolism_0.46351968
116MP0005452_abnormal_adipose_tissue0.46318714
117MP0002168_other_aberrant_phenotype0.45511853
118MP0006138_congestive_heart_failure0.45485510
119MP0002234_abnormal_pharynx_morphology0.44889426
120MP0003959_abnormal_lean_body0.44846804
121MP0002796_impaired_skin_barrier0.43914894
122MP0000639_abnormal_adrenal_gland0.43610038
123MP0005395_other_phenotype0.43095152
124MP0002928_abnormal_bile_duct0.42848233
125MP0008438_abnormal_cutaneous_collagen0.42704796
126MP0001299_abnormal_eye_distance/0.42508675
127MP0000003_abnormal_adipose_tissue0.40742749
128MP0005253_abnormal_eye_physiology0.40690594
129MP0004215_abnormal_myocardial_fiber0.39935358
130MP0005385_cardiovascular_system_phenoty0.39419899
131MP0001544_abnormal_cardiovascular_syste0.39419899
132MP0008775_abnormal_heart_ventricle0.38784813
133MP0003724_increased_susceptibility_to0.38531116
134MP0000747_muscle_weakness0.38461320
135MP0003075_altered_response_to0.38289453
136MP0009053_abnormal_anal_canal0.37446106
137MP0003221_abnormal_cardiomyocyte_apopto0.37198729
138MP0004087_abnormal_muscle_fiber0.37051199
139MP0008874_decreased_physiological_sensi0.36971761
140MP0005620_abnormal_muscle_contractility0.35714847
141MP0002332_abnormal_exercise_endurance0.35692134
142MP0005165_increased_susceptibility_to0.35020721

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.32789333
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.31687080
3Deep venous thrombosis (HP:0002625)5.94461282
4Xanthomatosis (HP:0000991)5.65593806
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.45029003
6Prolonged partial thromboplastin time (HP:0003645)5.16491390
7Hypobetalipoproteinemia (HP:0003563)5.13651519
8Hyperglycinuria (HP:0003108)5.08634699
9Hyperlipoproteinemia (HP:0010980)4.86386509
10* Hyperammonemia (HP:0001987)4.81912332
11* Ketosis (HP:0001946)4.67103331
12Complement deficiency (HP:0004431)4.57038323
13* Abnormality of glycine metabolism (HP:0010895)4.56735877
14* Abnormality of serine family amino acid metabolism (HP:0010894)4.56735877
15Hypoglycemic coma (HP:0001325)4.55947096
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.22118475
17Abnormality of fatty-acid metabolism (HP:0004359)4.21272428
18* Hyperglycinemia (HP:0002154)4.20156473
19Hypolipoproteinemia (HP:0010981)4.19973084
20Epidermoid cyst (HP:0200040)4.05933166
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.02047634
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93577391
23Hypoalphalipoproteinemia (HP:0003233)3.92996704
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.83958739
25* Ketoacidosis (HP:0001993)3.76933787
26Joint hemorrhage (HP:0005261)3.72226073
27Abnormality of the common coagulation pathway (HP:0010990)3.70676271
28Abnormality of methionine metabolism (HP:0010901)3.68861798
29Fat malabsorption (HP:0002630)3.63908263
30Increased serum pyruvate (HP:0003542)3.63370011
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.62370995
32Abnormality of glycolysis (HP:0004366)3.37291155
33Abnormality of the intrinsic pathway (HP:0010989)3.35588884
34* Dicarboxylic aciduria (HP:0003215)3.28998918
35* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28998918
36Gout (HP:0001997)3.26292943
37Abnormality of complement system (HP:0005339)3.21300369
38Hypercholesterolemia (HP:0003124)3.10877480
39Abnormality of purine metabolism (HP:0004352)3.10201538
40Generalized aminoaciduria (HP:0002909)3.05516326
41* Abnormality of serum amino acid levels (HP:0003112)3.03631876
42* Metabolic acidosis (HP:0001942)3.02893529
43Abnormality of nucleobase metabolism (HP:0010932)3.01654720
44Cerebral edema (HP:0002181)3.01053810
45Conjugated hyperbilirubinemia (HP:0002908)2.97802244
46* Lethargy (HP:0001254)2.96154475
47Hyperbilirubinemia (HP:0002904)2.91470868
48Abnormality of pyrimidine metabolism (HP:0004353)2.84561084
49Proximal tubulopathy (HP:0000114)2.77111512
50Steatorrhea (HP:0002570)2.76914861
51Skin nodule (HP:0200036)2.75421891
52Abnormality of alanine metabolism (HP:0010916)2.72823252
53Hyperalaninemia (HP:0003348)2.72823252
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72823252
55Hepatocellular carcinoma (HP:0001402)2.69648418
56Myoglobinuria (HP:0002913)2.68647749
57Osteomalacia (HP:0002749)2.59045170
58Hyperphosphaturia (HP:0003109)2.56310414
59Vascular calcification (HP:0004934)2.54754687
60* Abnormality of vitamin metabolism (HP:0100508)2.52740342
61* Vomiting (HP:0002013)2.52506389
62Hypoglycemic seizures (HP:0002173)2.51506755
63Myocardial infarction (HP:0001658)2.49550689
64Increased purine levels (HP:0004368)2.41501534
65Hyperuricemia (HP:0002149)2.41501534
66Hydroxyprolinuria (HP:0003080)2.38103938
67Abnormality of proline metabolism (HP:0010907)2.38103938
68Spastic diplegia (HP:0001264)2.34334255
69* Delayed CNS myelination (HP:0002188)2.33461702
70Glycosuria (HP:0003076)2.30865597
71Abnormality of urine glucose concentration (HP:0011016)2.30865597
72Cardiovascular calcification (HP:0011915)2.30297818
73Enlarged kidneys (HP:0000105)2.29597985
74Hyperinsulinemic hypoglycemia (HP:0000825)2.29595113
75Systemic lupus erythematosus (HP:0002725)2.28654729
76Irritability (HP:0000737)2.28198052
77Renal cortical cysts (HP:0000803)2.27725242
78Alkalosis (HP:0001948)2.25285639
79Abnormal gallbladder morphology (HP:0012437)2.24081937
80Sensorimotor neuropathy (HP:0007141)2.23811389
81Cholelithiasis (HP:0001081)2.21522907
82Neonatal onset (HP:0003623)2.20815673
83Late onset (HP:0003584)2.19409776
84Malnutrition (HP:0004395)2.15363443
85Nausea (HP:0002018)2.12612469
86* Pancreatitis (HP:0001733)2.10827589
87Spontaneous abortion (HP:0005268)2.07535965
88Hypochromic microcytic anemia (HP:0004840)2.05030259
89Hepatic necrosis (HP:0002605)2.00523109
90Abnormal cartilage morphology (HP:0002763)1.99976748
91Abnormal urine phosphate concentration (HP:0012599)1.99315076
92Atrioventricular block (HP:0001678)1.99279643
93Acanthocytosis (HP:0001927)1.98793630
94Rhabdomyolysis (HP:0003201)1.98599637
95Cholecystitis (HP:0001082)1.97576420
96Abnormal gallbladder physiology (HP:0012438)1.97576420
97Brushfield spots (HP:0001088)1.96867121
98Acute encephalopathy (HP:0006846)1.96679670
99Reduced antithrombin III activity (HP:0001976)1.94197732
100Fair hair (HP:0002286)1.90602983
101Esophageal varix (HP:0002040)1.90554062
102Symptomatic seizures (HP:0011145)1.88943566
103Exercise-induced muscle cramps (HP:0003710)1.87340930
104Amyloidosis (HP:0011034)1.86729277
105Rickets (HP:0002748)1.86370031
106Hyperglycemia (HP:0003074)1.85800136
107Glomerulonephritis (HP:0000099)1.85484043
108Hypertriglyceridemia (HP:0002155)1.84950124
109Acute hepatic failure (HP:0006554)1.82376598
110Opisthotonus (HP:0002179)1.81761818
111Mitral stenosis (HP:0001718)1.81635462
112Abnormality of the gallbladder (HP:0005264)1.80605574
113Elevated hepatic transaminases (HP:0002910)1.79529404
114Nephritis (HP:0000123)1.78280264
115Increased muscle lipid content (HP:0009058)1.77480928
116Papillary thyroid carcinoma (HP:0002895)1.75601086
117Megaloblastic anemia (HP:0001889)1.74477503
118Insulin-resistant diabetes mellitus (HP:0000831)1.72638621
119Pancreatic islet-cell hyperplasia (HP:0004510)1.71482130
120Rimmed vacuoles (HP:0003805)1.63352712
121Renal tubular dysfunction (HP:0000124)1.62887078
122Back pain (HP:0003418)1.61778231
123Cortical dysplasia (HP:0002539)1.61560496
124Neonatal hypoglycemia (HP:0001998)1.58291065
125Azoospermia (HP:0000027)1.57354105
126Abnormal delivery (HP:0001787)1.50283853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.62285481
2SIK13.81358934
3FGFR43.11712882
4ERN12.96768316
5TRIM282.83657333
6EIF2AK32.71477737
7ERBB32.68157589
8INSRR2.59958870
9PKN22.55398002
10TRIB32.45902850
11PDK42.27174110
12PDK32.27174110
13WNK42.23051321
14EIF2AK12.03078270
15BCR1.99471563
16MAP4K21.98639038
17MST1R1.97016694
18FLT31.92628857
19ERBB41.85196877
20FRK1.79236337
21TAOK31.75840299
22BRSK21.70611429
23OXSR11.70280993
24PINK11.63789282
25CCNB11.53521508
26MAP2K41.51696862
27CASK1.50984139
28NEK11.48148938
29CAMK1D1.48027485
30LATS11.47872717
31PIK3CG1.45842995
32WNK31.45016105
33PDK21.43891398
34NEK91.42951272
35MAPK111.42789088
36STK391.39312056
37MARK11.39168665
38FGFR21.37828527
39PRKAA21.36767432
40OBSCN1.27789410
41MET1.27054271
42PBK1.23677802
43PTK61.22823196
44STK38L1.22740255
45CSNK1G21.18558839
46LMTK21.18194947
47GRK11.17851498
48TTK1.17311647
49ACVR1B1.17208418
50TIE11.13516104
51TTN1.11968187
52ABL21.11809402
53MAP3K71.11479566
54ARAF1.07524949
55CSNK1G31.06874714
56TESK21.06680369
57MAP3K41.02507454
58NTRK31.02319740
59JAK20.99415765
60MYLK0.98164245
61MAP3K120.97585356
62PHKG20.97388651
63PHKG10.97388651
64EPHB10.96616993
65PLK20.94902067
66MAP3K30.93718057
67LIMK10.91803174
68TYK20.91718758
69PRKAA10.89842138
70BRSK10.87915874
71PRKCE0.86795118
72MST40.84936173
73CAMKK20.84139164
74KDR0.82989385
75PIK3CA0.82321818
76MAP2K30.81209418
77BRAF0.80284407
78PNCK0.79934720
79CAMK1G0.78686262
80SGK2230.77364704
81SGK4940.77364704
82CAMK2D0.77135506
83MAP2K70.76667525
84RIPK10.76231083
85WEE10.76048109
86JAK10.75047145
87MINK10.74917445
88PRKACG0.74862205
89SCYL20.73071512
90GSK3A0.72981111
91CSNK1A1L0.72843067
92PDPK10.72607699
93SGK30.72406498
94MAPK120.72049371
95CSNK1E0.70694597
96DAPK20.69711723
97TGFBR20.67648500
98MUSK0.67433846
99PRKCG0.67406373
100PLK10.66477233
101PAK30.64984083
102CDK90.64193084
103PLK30.63710990
104MAP3K20.63604852
105CAMK2G0.61964344
106AKT20.61816233
107EIF2AK20.60486258
108SGK20.59133074
109PDGFRA0.58560228
110TESK10.57680646
111EPHA30.56736947
112SRPK10.56203292
113PRKCZ0.55632909
114CAMK2A0.55134271
115MAP2K10.52626052
116UHMK10.52213823
117CDK60.51332310
118ERBB20.51198099
119TRPM70.51182063
120MAPK40.51047622
121FER0.50811958
122NEK60.50550129
123CSNK1A10.50157329
124MAP3K50.47974028
125CSNK1G10.47806639
126CAMK2B0.47781062
127PDK10.45959224
128FGFR30.45523275
129RET0.44239607
130MAPK150.43584820
131IGF1R0.42995686
132KSR10.41255172
133PRKCQ0.41177523
134PRKD10.40523282
135MOS0.39470080
136TNIK0.38644748
137CSNK2A20.38431083
138YES10.37793562
139NTRK20.37461419
140IRAK10.36281389
141DYRK1B0.34393247
142PTK20.34157575
143IRAK20.33006303
144LRRK20.32178769
145TBK10.32076893
146AKT30.30197144
147MAPK70.30048319
148GRK60.29775256
149PKN10.29137655
150PRKACB0.28689434
151PRKACA0.28519952
152MTOR0.27748423
153CSK0.27616838
154IRAK30.25727307
155MAP2K60.25370358
156EPHA40.25185087
157STK380.23275613
158CAMK40.22055230

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.82942726
2Nitrogen metabolism_Homo sapiens_hsa009103.39284585
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01046283
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98077163
5Fatty acid degradation_Homo sapiens_hsa000712.95795473
6* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94663544
7* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73997354
8* Propanoate metabolism_Homo sapiens_hsa006402.70639300
9Arginine biosynthesis_Homo sapiens_hsa002202.63999279
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61927557
11Tryptophan metabolism_Homo sapiens_hsa003802.59389516
12Butanoate metabolism_Homo sapiens_hsa006502.47670657
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37132878
14Fatty acid metabolism_Homo sapiens_hsa012122.32427848
15Peroxisome_Homo sapiens_hsa041462.18313206
16Complement and coagulation cascades_Homo sapiens_hsa046102.17460813
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13762353
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12550402
19PPAR signaling pathway_Homo sapiens_hsa033202.07534717
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93209263
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91367897
22beta-Alanine metabolism_Homo sapiens_hsa004101.84813812
23Pyruvate metabolism_Homo sapiens_hsa006201.79074261
24Chemical carcinogenesis_Homo sapiens_hsa052041.67189818
25Fatty acid elongation_Homo sapiens_hsa000621.66527153
26Histidine metabolism_Homo sapiens_hsa003401.66488156
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66259405
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65516736
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58824411
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.58252677
31Sulfur metabolism_Homo sapiens_hsa009201.57983821
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56907448
33* Carbon metabolism_Homo sapiens_hsa012001.49146266
34Caffeine metabolism_Homo sapiens_hsa002321.47781695
35Phenylalanine metabolism_Homo sapiens_hsa003601.45740371
36Retinol metabolism_Homo sapiens_hsa008301.42008289
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41728327
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.41172066
39Bile secretion_Homo sapiens_hsa049761.39495179
40Selenocompound metabolism_Homo sapiens_hsa004501.37552154
41Starch and sucrose metabolism_Homo sapiens_hsa005001.36020425
42Tyrosine metabolism_Homo sapiens_hsa003501.32485775
43Biosynthesis of amino acids_Homo sapiens_hsa012301.26860317
44Staphylococcus aureus infection_Homo sapiens_hsa051501.26370506
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.18367393
46Fat digestion and absorption_Homo sapiens_hsa049751.17032821
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15934140
48Steroid biosynthesis_Homo sapiens_hsa001001.06225965
49Folate biosynthesis_Homo sapiens_hsa007901.06225647
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04982993
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04621494
52ABC transporters_Homo sapiens_hsa020101.04028420
53Arginine and proline metabolism_Homo sapiens_hsa003301.00705208
54Fatty acid biosynthesis_Homo sapiens_hsa000610.96041000
55Glycerolipid metabolism_Homo sapiens_hsa005610.91680128
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89287691
57Lysine degradation_Homo sapiens_hsa003100.87549633
58Vitamin digestion and absorption_Homo sapiens_hsa049770.86363818
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.86236811
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82965212
61Glutathione metabolism_Homo sapiens_hsa004800.75067096
62Sulfur relay system_Homo sapiens_hsa041220.73919348
63Vitamin B6 metabolism_Homo sapiens_hsa007500.72008174
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71699554
65Pentose phosphate pathway_Homo sapiens_hsa000300.57098534
66* Metabolic pathways_Homo sapiens_hsa011000.52997624
67Circadian rhythm_Homo sapiens_hsa047100.52933321
68One carbon pool by folate_Homo sapiens_hsa006700.46559986
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.41571642
70Protein export_Homo sapiens_hsa030600.40706092
71Insulin resistance_Homo sapiens_hsa049310.37314855
72Fructose and mannose metabolism_Homo sapiens_hsa000510.35940544
73Galactose metabolism_Homo sapiens_hsa000520.32602499
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31978635
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30495299
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30261576
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27409006
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24986725
79Glucagon signaling pathway_Homo sapiens_hsa049220.23243393
80Vibrio cholerae infection_Homo sapiens_hsa051100.20572204
81Linoleic acid metabolism_Homo sapiens_hsa005910.20045137
82AMPK signaling pathway_Homo sapiens_hsa041520.19897385
83Prion diseases_Homo sapiens_hsa050200.19479163
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.16512304
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15753538
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14116947
87Oxidative phosphorylation_Homo sapiens_hsa001900.13021629
88N-Glycan biosynthesis_Homo sapiens_hsa005100.12425684
89Serotonergic synapse_Homo sapiens_hsa047260.10739901
90Collecting duct acid secretion_Homo sapiens_hsa049660.10419087
91Parkinsons disease_Homo sapiens_hsa050120.07256540
92Oocyte meiosis_Homo sapiens_hsa041140.06240554
93Insulin secretion_Homo sapiens_hsa049110.04493286
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03168469
95Insulin signaling pathway_Homo sapiens_hsa049100.02660388
96Synaptic vesicle cycle_Homo sapiens_hsa047210.02127951
97Sphingolipid metabolism_Homo sapiens_hsa006000.01760992
98GABAergic synapse_Homo sapiens_hsa047270.01758804
99Renin secretion_Homo sapiens_hsa049240.00215160
100Cardiac muscle contraction_Homo sapiens_hsa04260-0.1595708
101Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1587762
102Mineral absorption_Homo sapiens_hsa04978-0.1483185
103Regulation of autophagy_Homo sapiens_hsa04140-0.1377092
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1282858
105Lysosome_Homo sapiens_hsa04142-0.1227259
106Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1033818
107Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1014677
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0992820
109Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0855175
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0766480
111Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0719872
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0625270
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0497516
114Renin-angiotensin system_Homo sapiens_hsa04614-0.0345525
115Protein digestion and absorption_Homo sapiens_hsa04974-0.0305792
116Alzheimers disease_Homo sapiens_hsa05010-0.0068757

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