MUTYH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.55988031
2DNA strand elongation (GO:0022616)5.29985274
3telomere maintenance via semi-conservative replication (GO:0032201)5.29386928
4DNA unwinding involved in DNA replication (GO:0006268)5.20905598
5DNA replication initiation (GO:0006270)5.11905347
6protein localization to kinetochore (GO:0034501)4.78939281
7telomere maintenance via recombination (GO:0000722)4.73097798
8nucleobase biosynthetic process (GO:0046112)4.59372363
9mitotic metaphase plate congression (GO:0007080)4.57086682
10mitotic recombination (GO:0006312)4.56835896
11DNA replication checkpoint (GO:0000076)4.49195536
12telomere maintenance via telomere lengthening (GO:0010833)4.37563671
13DNA deamination (GO:0045006)4.36111328
14maturation of SSU-rRNA (GO:0030490)4.33013912
15nucleotide-excision repair, DNA gap filling (GO:0006297)4.30634935
16purine nucleobase biosynthetic process (GO:0009113)4.30239234
17ribosomal small subunit assembly (GO:0000028)4.27282478
18formation of translation preinitiation complex (GO:0001731)4.21585379
19CENP-A containing nucleosome assembly (GO:0034080)4.13287473
20chromatin remodeling at centromere (GO:0031055)4.06457909
21protein localization to chromosome, centromeric region (GO:0071459)4.02672304
22attachment of spindle microtubules to kinetochore (GO:0008608)4.01453730
23metaphase plate congression (GO:0051310)3.93796687
24DNA replication-independent nucleosome assembly (GO:0006336)3.87741370
25DNA replication-independent nucleosome organization (GO:0034724)3.87741370
26DNA replication-dependent nucleosome organization (GO:0034723)3.85559070
27DNA replication-dependent nucleosome assembly (GO:0006335)3.85559070
28mitotic sister chromatid segregation (GO:0000070)3.82483323
29mitotic nuclear envelope disassembly (GO:0007077)3.81798496
30kinetochore organization (GO:0051383)3.76114143
31IMP biosynthetic process (GO:0006188)3.75678430
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.69186881
33ubiquinone biosynthetic process (GO:0006744)3.66987566
34viral transcription (GO:0019083)3.66644721
35establishment of chromosome localization (GO:0051303)3.61910558
36somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61299117
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.61299117
38mitotic chromosome condensation (GO:0007076)3.61056165
39translational termination (GO:0006415)3.60635072
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60603257
41ribosome biogenesis (GO:0042254)3.56935323
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.54370208
43ribosomal large subunit biogenesis (GO:0042273)3.53330678
44iron-sulfur cluster assembly (GO:0016226)3.52474624
45metallo-sulfur cluster assembly (GO:0031163)3.52474624
46transcription-coupled nucleotide-excision repair (GO:0006283)3.52291299
47kinetochore assembly (GO:0051382)3.51612641
48regulation of spindle organization (GO:0090224)3.50842777
49nuclear envelope disassembly (GO:0051081)3.49780009
50membrane disassembly (GO:0030397)3.49780009
51regulation of double-strand break repair via homologous recombination (GO:0010569)3.48747217
52respiratory chain complex IV assembly (GO:0008535)3.47421527
53ribonucleoprotein complex biogenesis (GO:0022613)3.47307438
54DNA double-strand break processing (GO:0000729)3.44793739
55DNA catabolic process, exonucleolytic (GO:0000738)3.44439512
56histone exchange (GO:0043486)3.43782816
57cytochrome complex assembly (GO:0017004)3.43746175
58piRNA metabolic process (GO:0034587)3.43266213
59sister chromatid segregation (GO:0000819)3.42493677
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40404818
61water-soluble vitamin biosynthetic process (GO:0042364)3.39873272
62ubiquinone metabolic process (GO:0006743)3.37838855
63replication fork processing (GO:0031297)3.37116520
64ribosomal small subunit biogenesis (GO:0042274)3.36976363
65translational elongation (GO:0006414)3.36883280
66DNA duplex unwinding (GO:0032508)3.36871641
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36031780
68DNA geometric change (GO:0032392)3.35914014
69establishment of integrated proviral latency (GO:0075713)3.34827459
70pseudouridine synthesis (GO:0001522)3.33113651
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32606055
72spliceosomal snRNP assembly (GO:0000387)3.31889046
73IMP metabolic process (GO:0046040)3.31232893
74synapsis (GO:0007129)3.30960285
75translational initiation (GO:0006413)3.30659723
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30326352
77folic acid-containing compound biosynthetic process (GO:0009396)3.29405032
78telomere organization (GO:0032200)3.29167705
79telomere maintenance (GO:0000723)3.28827574
80rRNA processing (GO:0006364)3.26927038
81protein complex biogenesis (GO:0070271)3.26001569
82mitochondrial respiratory chain complex assembly (GO:0033108)3.25580883
83platelet dense granule organization (GO:0060155)3.22567123
84peptidyl-histidine modification (GO:0018202)3.22276218
85negative regulation of chromosome segregation (GO:0051985)3.17943675
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16820790
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16185175
88regulation of mitotic spindle checkpoint (GO:1903504)3.16185175
89rRNA metabolic process (GO:0016072)3.15903958
90negative regulation of telomere maintenance (GO:0032205)3.15633607
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14917575
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14443603
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.14327669
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14327669
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14327669
96negative regulation of sister chromatid segregation (GO:0033046)3.14327669
97cullin deneddylation (GO:0010388)3.13840616
98spindle checkpoint (GO:0031577)3.12212279
99nuclear pore organization (GO:0006999)3.12003800
100ribosome assembly (GO:0042255)3.11532383
101G1/S transition of mitotic cell cycle (GO:0000082)3.10230437
102cell cycle G1/S phase transition (GO:0044843)3.10230437
103mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09537060
104mitochondrial respiratory chain complex I assembly (GO:0032981)3.09537060
105NADH dehydrogenase complex assembly (GO:0010257)3.09537060
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08597320
107regulation of chromosome segregation (GO:0051983)3.08164527
108* base-excision repair, AP site formation (GO:0006285)3.07774270
109spindle assembly checkpoint (GO:0071173)3.07477855
110pyrimidine nucleotide catabolic process (GO:0006244)3.04996509
111mitotic spindle assembly checkpoint (GO:0007094)3.04134891
112tRNA modification (GO:0006400)3.02608829
113negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02323500
114* mismatch repair (GO:0006298)3.01825826
115spliceosomal complex assembly (GO:0000245)3.01585725
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01113375
117chromatin assembly or disassembly (GO:0006333)3.00139264
118proteasome assembly (GO:0043248)2.99866114
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99687897
120L-fucose catabolic process (GO:0042355)2.99123021
121fucose catabolic process (GO:0019317)2.99123021
122L-fucose metabolic process (GO:0042354)2.99123021
123positive regulation of chromosome segregation (GO:0051984)2.98989848
124* base-excision repair (GO:0006284)2.98391877
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97342048
126regulation of mitochondrial translation (GO:0070129)2.97037877
127protein localization to chromosome (GO:0034502)2.95216397
128viral mRNA export from host cell nucleus (GO:0046784)2.95177815
129regulation of centrosome cycle (GO:0046605)2.94367673
130cotranslational protein targeting to membrane (GO:0006613)2.93371357
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93300089
132energy coupled proton transport, down electrochemical gradient (GO:0015985)2.93186866
133ATP synthesis coupled proton transport (GO:0015986)2.93186866
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92543906
135mitotic spindle checkpoint (GO:0071174)2.91678107
136protein targeting to ER (GO:0045047)2.91148936
137tRNA processing (GO:0008033)2.91132869
138mitochondrial RNA metabolic process (GO:0000959)2.88494312
139protein deneddylation (GO:0000338)2.85653836
140positive regulation of prostaglandin secretion (GO:0032308)2.85147445
141meiotic chromosome segregation (GO:0045132)2.84451251
142quinone biosynthetic process (GO:1901663)2.84382743
143DNA methylation involved in gamete generation (GO:0043046)2.81330404
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80286490
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80286490
146histone H2A acetylation (GO:0043968)2.78345418
147protein-cofactor linkage (GO:0018065)2.74166410
148preassembly of GPI anchor in ER membrane (GO:0016254)2.71942273
149protein K6-linked ubiquitination (GO:0085020)2.70435381
150behavioral response to nicotine (GO:0035095)2.68746317
151mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.67913962
152reciprocal meiotic recombination (GO:0007131)2.67032341
153reciprocal DNA recombination (GO:0035825)2.67032341
154tRNA metabolic process (GO:0006399)2.66938498
155negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64936434
156transcription elongation from RNA polymerase III promoter (GO:0006385)2.63429873
157termination of RNA polymerase III transcription (GO:0006386)2.63429873
158intra-S DNA damage checkpoint (GO:0031573)2.63139578
159recombinational repair (GO:0000725)2.60107154
160double-strand break repair via homologous recombination (GO:0000724)2.60069027
161mannosylation (GO:0097502)2.59911796
162DNA recombination (GO:0006310)2.56920297
163somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.52979721
164somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.52979721
165isotype switching (GO:0045190)2.52979721
166axoneme assembly (GO:0035082)2.52267682
167male meiosis I (GO:0007141)2.50582075
168branched-chain amino acid catabolic process (GO:0009083)2.50533947
169ncRNA metabolic process (GO:0034660)2.47797404
170DNA damage response, detection of DNA damage (GO:0042769)2.44825168
171* deoxyribonucleotide catabolic process (GO:0009264)2.44161445
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43108311
173anterograde synaptic vesicle transport (GO:0048490)2.42879459
174rRNA modification (GO:0000154)2.42006926
175ncRNA processing (GO:0034470)2.41511891
176positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41291273
177GPI anchor metabolic process (GO:0006505)2.40348115
178L-serine metabolic process (GO:0006563)2.40179732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.41945565
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.27507076
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.24910915
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82940962
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60245525
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21656036
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18041076
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04664430
9ZNF274_21170338_ChIP-Seq_K562_Hela2.96525024
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.90644692
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85460589
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81804634
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75582415
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.74245011
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.64836512
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53366690
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49396869
18XRN2_22483619_ChIP-Seq_HELA_Human2.33679412
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31716777
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19152604
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17402277
22VDR_23849224_ChIP-Seq_CD4+_Human2.15550689
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13864918
24AR_21909140_ChIP-Seq_LNCAP_Human2.11860350
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09720504
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.02900755
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98161909
28FOXP3_21729870_ChIP-Seq_TREG_Human1.96150634
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94264760
30DCP1A_22483619_ChIP-Seq_HELA_Human1.92040387
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91305402
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83404776
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83344199
34GABP_19822575_ChIP-Seq_HepG2_Human1.82243357
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81463579
36* CIITA_25753668_ChIP-Seq_RAJI_Human1.80403089
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80307427
38IRF1_19129219_ChIP-ChIP_H3396_Human1.78776266
39TTF2_22483619_ChIP-Seq_HELA_Human1.76647983
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73363784
41IGF1R_20145208_ChIP-Seq_DFB_Human1.72294875
42MYC_22102868_ChIP-Seq_BL_Human1.70552856
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69549039
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68624952
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.67890289
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66034617
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66022220
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64695228
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58583978
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.57615915
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57294947
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54945392
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51436519
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46320818
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45534097
56VDR_22108803_ChIP-Seq_LS180_Human1.45512277
57KDM5A_27292631_Chip-Seq_BREAST_Human1.40702543
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.38720551
59ELK1_19687146_ChIP-ChIP_HELA_Human1.38543432
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38459130
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38331908
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37640813
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36326879
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33773161
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.33104035
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32850086
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29308953
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27601037
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26156403
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24951072
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23383697
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.22857851
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22038314
74* TP53_22573176_ChIP-Seq_HFKS_Human1.21984446
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20996824
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20026509
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17245652
78* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16787739
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16650692
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15601143
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15040300
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12523736
83* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10797735
84* VDR_21846776_ChIP-Seq_THP-1_Human1.10690318
85EWS_26573619_Chip-Seq_HEK293_Human1.10238977
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09817294
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08643310
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06412262
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06297465
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.06066115
91* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05530147
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03698800
93TFEB_21752829_ChIP-Seq_HELA_Human1.01409931
94MYC_18940864_ChIP-ChIP_HL60_Human1.00016742
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.99267051
96BCL6_27268052_Chip-Seq_Bcells_Human0.98825580
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97384912
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97003808
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96414467
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.96239589
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94922591
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.94610908
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94359196
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.94218122
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93830718
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.93756184
107* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92738433
108PHF8_20622854_ChIP-Seq_HELA_Human0.90806975
109SPI1_23547873_ChIP-Seq_NB4_Human0.89320923
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89114928
111E2F1_20622854_ChIP-Seq_HELA_Human0.88551516
112ERA_21632823_ChIP-Seq_H3396_Human0.87865685
113GATA3_21878914_ChIP-Seq_MCF-7_Human0.87522499
114* NANOG_20526341_ChIP-Seq_ESCs_Human0.86949592
115GATA3_26560356_Chip-Seq_TH2_Human0.86639431
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.85376505
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.84391580
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84391580
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84173661
120AR_20517297_ChIP-Seq_VCAP_Human0.84040988
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82780027
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82450669
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82439951
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82186627
125* MYB_26560356_Chip-Seq_TH2_Human0.82103343
126P300_27268052_Chip-Seq_Bcells_Human0.81915965
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81803283
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79971008
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78340242
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76387350
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75159816
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73503000
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73001370
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.72289630
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70941683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.60457100
2MP0010094_abnormal_chromosome_stability5.33151078
3MP0003111_abnormal_nucleus_morphology4.92460134
4MP0004957_abnormal_blastocyst_morpholog4.73212375
5MP0008057_abnormal_DNA_replication4.48413999
6MP0003077_abnormal_cell_cycle4.39185720
7MP0008058_abnormal_DNA_repair3.84822518
8MP0008007_abnormal_cellular_replicative3.10639215
9MP0002396_abnormal_hematopoietic_system3.04544542
10MP0008932_abnormal_embryonic_tissue2.78342588
11MP0002102_abnormal_ear_morphology2.51280777
12MP0003123_paternal_imprinting2.47912390
13MP0008877_abnormal_DNA_methylation2.44994523
14MP0001730_embryonic_growth_arrest2.44345458
15MP0000350_abnormal_cell_proliferation2.35537094
16MP0005645_abnormal_hypothalamus_physiol2.14011239
17MP0000372_irregular_coat_pigmentation2.11082599
18MP0003786_premature_aging2.05708309
19MP0006072_abnormal_retinal_apoptosis2.04502694
20MP0010352_gastrointestinal_tract_polyps1.97676971
21MP0004147_increased_porphyrin_level1.89509098
22MP0005671_abnormal_response_to1.88172503
23MP0002938_white_spotting1.80572009
24MP0001697_abnormal_embryo_size1.77807102
25MP0001672_abnormal_embryogenesis/_devel1.76635065
26MP0005380_embryogenesis_phenotype1.76635065
27MP0010307_abnormal_tumor_latency1.71145339
28MP0003718_maternal_effect1.69973750
29MP0001968_abnormal_touch/_nociception1.68139377
30MP0000490_abnormal_crypts_of1.63904969
31MP0005551_abnormal_eye_electrophysiolog1.63153552
32MP0002080_prenatal_lethality1.62034112
33* MP0002019_abnormal_tumor_incidence1.61969076
34MP0003984_embryonic_growth_retardation1.57626356
35MP0000313_abnormal_cell_death1.57461402
36MP0001986_abnormal_taste_sensitivity1.53894371
37MP0002085_abnormal_embryonic_tissue1.53158280
38MP0002088_abnormal_embryonic_growth/wei1.51904229
39MP0003646_muscle_fatigue1.51564203
40MP0004808_abnormal_hematopoietic_stem1.51450892
41MP0005253_abnormal_eye_physiology1.51284274
42MP0008872_abnormal_physiological_respon1.51010963
43MP0003763_abnormal_thymus_physiology1.50493238
44MP0003195_calcinosis1.46355097
45MP0001764_abnormal_homeostasis1.42454938
46MP0005377_hearing/vestibular/ear_phenot1.41298627
47MP0003878_abnormal_ear_physiology1.41298627
48MP0008789_abnormal_olfactory_epithelium1.41040644
49MP0004133_heterotaxia1.40470153
50MP0005084_abnormal_gallbladder_morpholo1.38057560
51MP0002084_abnormal_developmental_patter1.37016798
52MP0002210_abnormal_sex_determination1.34046623
53MP0008875_abnormal_xenobiotic_pharmacok1.33695072
54MP0000703_abnormal_thymus_morphology1.33336960
55MP0002736_abnormal_nociception_after1.32784947
56MP0002086_abnormal_extraembryonic_tissu1.32180720
57MP0009333_abnormal_splenocyte_physiolog1.32010873
58MP0008995_early_reproductive_senescence1.29188660
59MP0002837_dystrophic_cardiac_calcinosis1.28226301
60MP0003121_genomic_imprinting1.27844131
61MP0003890_abnormal_embryonic-extraembry1.26598631
62MP0003567_abnormal_fetal_cardiomyocyte1.26327419
63MP0001545_abnormal_hematopoietic_system1.25113162
64MP0005397_hematopoietic_system_phenotyp1.25113162
65MP0005646_abnormal_pituitary_gland1.24545007
66MP0006292_abnormal_olfactory_placode1.23300433
67MP0002398_abnormal_bone_marrow1.21053915
68MP0002928_abnormal_bile_duct1.20374647
69MP0004197_abnormal_fetal_growth/weight/1.18657531
70MP0002277_abnormal_respiratory_mucosa1.18254367
71MP0001145_abnormal_male_reproductive1.18022533
72MP0002722_abnormal_immune_system1.16699925
73MP0010030_abnormal_orbit_morphology1.16630713
74MP0001984_abnormal_olfaction1.16199764
75MP0001293_anophthalmia1.15179856
76MP0003787_abnormal_imprinting1.14950439
77MP0005174_abnormal_tail_pigmentation1.14313049
78MP0005499_abnormal_olfactory_system1.12310809
79MP0005394_taste/olfaction_phenotype1.12310809
80MP0000689_abnormal_spleen_morphology1.12173887
81MP0003806_abnormal_nucleotide_metabolis1.10355693
82MP0003011_delayed_dark_adaptation1.09081149
83MP0001929_abnormal_gametogenesis1.07172939
84MP0002138_abnormal_hepatobiliary_system1.06989524
85MP0001873_stomach_inflammation1.04320866
86MP0000653_abnormal_sex_gland1.00807824
87MP0003698_abnormal_male_reproductive0.99341922
88MP0003315_abnormal_perineum_morphology0.98107734
89MP0009697_abnormal_copulation0.97348133
90MP0002638_abnormal_pupillary_reflex0.96949416
91MP0002163_abnormal_gland_morphology0.96843659
92MP0002160_abnormal_reproductive_system0.96371143
93MP0003119_abnormal_digestive_system0.95557452
94MP0004142_abnormal_muscle_tone0.95368382
95MP0002429_abnormal_blood_cell0.94959382
96MP0001529_abnormal_vocalization0.91214082
97MP0002735_abnormal_chemical_nociception0.90296386
98MP0002254_reproductive_system_inflammat0.90081617
99MP0004742_abnormal_vestibular_system0.89155611
100MP0009278_abnormal_bone_marrow0.89051993
101MP0003136_yellow_coat_color0.88986614
102MP0000631_abnormal_neuroendocrine_gland0.88570916
103MP0009672_abnormal_birth_weight0.87366731
104MP0001119_abnormal_female_reproductive0.86936096
105MP0002132_abnormal_respiratory_system0.86461655
106MP0002653_abnormal_ependyma_morphology0.86399944
107MP0002693_abnormal_pancreas_physiology0.85000108
108MP0000716_abnormal_immune_system0.84095580
109MP0009379_abnormal_foot_pigmentation0.83937226
110MP0000015_abnormal_ear_pigmentation0.83729235
111MP0001853_heart_inflammation0.83421925
112MP0005389_reproductive_system_phenotype0.81475723
113MP0009046_muscle_twitch0.80950198
114MP0000358_abnormal_cell_content/0.80315558
115MP0005076_abnormal_cell_differentiation0.78896992
116MP0000858_altered_metastatic_potential0.78655243
117MP0001905_abnormal_dopamine_level0.78525545
118MP0002751_abnormal_autonomic_nervous0.78454622
119MP0005410_abnormal_fertilization0.77816808
120MP0005384_cellular_phenotype0.77783882
121MP0005332_abnormal_amino_acid0.77688871
122MP0002111_abnormal_tail_morphology0.73534505
123MP0005075_abnormal_melanosome_morpholog0.73162335
124MP0001800_abnormal_humoral_immune0.73084406
125MP0003186_abnormal_redox_activity0.72868341
126MP0005621_abnormal_cell_physiology0.71734755
127MP0006036_abnormal_mitochondrial_physio0.65735015
128MP0002420_abnormal_adaptive_immunity0.63068409
129MP0001919_abnormal_reproductive_system0.61655793
130MP0009703_decreased_birth_body0.60419169
131MP0001819_abnormal_immune_cell0.60211555
132MP0000537_abnormal_urethra_morphology0.59401401
133MP0003221_abnormal_cardiomyocyte_apopto0.58901997
134MP0001835_abnormal_antigen_presentation0.58179628
135MP0009053_abnormal_anal_canal0.57112861
136MP0002075_abnormal_coat/hair_pigmentati0.56157292
137MP0000477_abnormal_intestine_morphology0.55534773
138MP0006035_abnormal_mitochondrial_morpho0.54730434
139MP0003699_abnormal_female_reproductive0.53059737
140MP0002452_abnormal_antigen_presenting0.52610430
141MP0001286_abnormal_eye_development0.52504460
142MP0005023_abnormal_wound_healing0.52231944
143MP0005266_abnormal_metabolism0.51761745
144MP0002092_abnormal_eye_morphology0.51704666
145MP0002405_respiratory_system_inflammati0.51602163
146MP0003941_abnormal_skin_development0.50925669
147MP0002161_abnormal_fertility/fecundity0.49854068
148MP0000685_abnormal_immune_system0.49345737
149MP0003937_abnormal_limbs/digits/tail_de0.48939625
150MP0002095_abnormal_skin_pigmentation0.48807564
151MP0001915_intracranial_hemorrhage0.48551446
152MP0002723_abnormal_immune_serum0.48277935

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.32523187
2Reticulocytopenia (HP:0001896)4.48618824
3Breast hypoplasia (HP:0003187)4.48585074
4Chromsome breakage (HP:0040012)4.33533797
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22502626
6Aplastic anemia (HP:0001915)4.05457643
7Oral leukoplakia (HP:0002745)3.94461862
8Congenital stationary night blindness (HP:0007642)3.81430220
9Abnormality of cells of the erythroid lineage (HP:0012130)3.65248106
10Selective tooth agenesis (HP:0001592)3.56181441
11Abnormal number of erythroid precursors (HP:0012131)3.54760746
12Medulloblastoma (HP:0002885)3.46586783
13Patellar aplasia (HP:0006443)3.44816395
14Abnormality of the preputium (HP:0100587)3.33070918
15Rough bone trabeculation (HP:0100670)3.25428480
16Meckel diverticulum (HP:0002245)3.25051787
17Carpal bone hypoplasia (HP:0001498)3.21971601
18Aplasia/Hypoplasia of the patella (HP:0006498)3.20508823
19Abnormality of chromosome stability (HP:0003220)3.18761539
20Hepatocellular necrosis (HP:0001404)3.14270957
21Attenuation of retinal blood vessels (HP:0007843)3.13599309
22Abnormality of the ileum (HP:0001549)3.10054348
23Degeneration of anterior horn cells (HP:0002398)3.04507704
24Abnormality of the anterior horn cell (HP:0006802)3.04507704
25Pancreatic cysts (HP:0001737)2.97597017
26Cerebral hypomyelination (HP:0006808)2.97549069
27Ependymoma (HP:0002888)2.96872716
28Abnormal rod and cone electroretinograms (HP:0008323)2.95797779
29Mitochondrial inheritance (HP:0001427)2.94610647
30Absent thumb (HP:0009777)2.91974549
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.91866830
32Abnormal number of incisors (HP:0011064)2.91122275
33Impulsivity (HP:0100710)2.90199759
34Hepatic necrosis (HP:0002605)2.89305134
35Agnosia (HP:0010524)2.88419863
36* Colon cancer (HP:0003003)2.87776736
37Microretrognathia (HP:0000308)2.86962472
38Pancreatic fibrosis (HP:0100732)2.86950024
39Methylmalonic aciduria (HP:0012120)2.85728175
40Increased CSF lactate (HP:0002490)2.80778699
41Bone marrow hypocellularity (HP:0005528)2.80657596
42Macrocytic anemia (HP:0001972)2.79703762
43Myelodysplasia (HP:0002863)2.78746414
44Premature graying of hair (HP:0002216)2.78484961
45Duodenal stenosis (HP:0100867)2.75715900
46Small intestinal stenosis (HP:0012848)2.75715900
47Methylmalonic acidemia (HP:0002912)2.73006755
48Neoplasm of the pancreas (HP:0002894)2.72461400
49True hermaphroditism (HP:0010459)2.71528119
50Cellular immunodeficiency (HP:0005374)2.70986416
5111 pairs of ribs (HP:0000878)2.70470363
52Abnormal lung lobation (HP:0002101)2.69812276
53Acute necrotizing encephalopathy (HP:0006965)2.68408931
54Molar tooth sign on MRI (HP:0002419)2.63195203
55Abnormality of midbrain morphology (HP:0002418)2.63195203
56Absent radius (HP:0003974)2.62682143
57Chronic hepatic failure (HP:0100626)2.62381629
58Abnormal mitochondria in muscle tissue (HP:0008316)2.60285223
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59303749
60Abnormal biliary tract physiology (HP:0012439)2.58019753
61Bile duct proliferation (HP:0001408)2.58019753
62Pallor (HP:0000980)2.56280768
63Sloping forehead (HP:0000340)2.56041467
64Increased serum lactate (HP:0002151)2.54458246
65Abnormality of the labia minora (HP:0012880)2.52364379
66Type I transferrin isoform profile (HP:0003642)2.52251426
67Rhabdomyosarcoma (HP:0002859)2.49505969
68Increased hepatocellular lipid droplets (HP:0006565)2.48768597
69Lipid accumulation in hepatocytes (HP:0006561)2.47863819
70Supernumerary spleens (HP:0009799)2.47079145
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46813486
72Abnormal protein N-linked glycosylation (HP:0012347)2.46813486
73Abnormal protein glycosylation (HP:0012346)2.46813486
74Abnormal glycosylation (HP:0012345)2.46813486
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44401395
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44401395
77Tracheoesophageal fistula (HP:0002575)2.43981660
78Absent forearm bone (HP:0003953)2.41770974
79Aplasia involving forearm bones (HP:0009822)2.41770974
80Pancytopenia (HP:0001876)2.39902102
81Acute encephalopathy (HP:0006846)2.39893609
82Horseshoe kidney (HP:0000085)2.37225159
83Abolished electroretinogram (ERG) (HP:0000550)2.37097848
84Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36204947
85Duplicated collecting system (HP:0000081)2.35515008
86Multiple enchondromatosis (HP:0005701)2.35508377
87Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34242186
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32958321
89Abnormality of the duodenum (HP:0002246)2.30815661
90Abnormal trabecular bone morphology (HP:0100671)2.29628680
91Ectopic kidney (HP:0000086)2.29469515
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28641002
93Lymphoma (HP:0002665)2.28536480
94Abnormality of the renal cortex (HP:0011035)2.28456902
95Thrombocytosis (HP:0001894)2.28023367
96Basal cell carcinoma (HP:0002671)2.27628597
97Lactic acidosis (HP:0003128)2.26875564
98Abnormality of B cell number (HP:0010975)2.24604824
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24274129
100Nephronophthisis (HP:0000090)2.23848702
101Increased nuchal translucency (HP:0010880)2.22931828
102Abnormality of the carotid arteries (HP:0005344)2.20376342
103Medial flaring of the eyebrow (HP:0010747)2.20095050
104Triphalangeal thumb (HP:0001199)2.20000982
105Progressive macrocephaly (HP:0004481)2.19969726
106Trismus (HP:0000211)2.19245192
107Short thumb (HP:0009778)2.18879763
1083-Methylglutaconic aciduria (HP:0003535)2.17775004
109Severe visual impairment (HP:0001141)2.17587884
110IgG deficiency (HP:0004315)2.16985212
111Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13694948
112Dicarboxylic aciduria (HP:0003215)2.13694948
113Squamous cell carcinoma (HP:0002860)2.12811097
114Abnormality of the renal collecting system (HP:0004742)2.12113673
115Panhypogammaglobulinemia (HP:0003139)2.11643639
116Premature ovarian failure (HP:0008209)2.10782460
117Cystic liver disease (HP:0006706)2.10621496
118Atresia of the external auditory canal (HP:0000413)2.10360840
119Cleft eyelid (HP:0000625)2.09161358
120Nephroblastoma (Wilms tumor) (HP:0002667)2.09081680
121Pendular nystagmus (HP:0012043)2.08829339
122Secondary amenorrhea (HP:0000869)2.08043365
123IgM deficiency (HP:0002850)2.07537257
124Progressive microcephaly (HP:0000253)2.06898846
125Hyperglycinuria (HP:0003108)2.05069401
126Renal cortical cysts (HP:0000803)2.05047291
127Increased intramyocellular lipid droplets (HP:0012240)2.02239103
128Stomatitis (HP:0010280)2.01944734
129Asplenia (HP:0001746)1.99643227
130Cafe-au-lait spot (HP:0000957)1.99406575
131Optic nerve coloboma (HP:0000588)1.99339521
132Abnormality of the renal medulla (HP:0100957)1.99287921
133Type 2 muscle fiber atrophy (HP:0003554)1.99215763
134Hyperglycinemia (HP:0002154)1.98543971
135Embryonal renal neoplasm (HP:0011794)1.98049561
136Decreased central vision (HP:0007663)1.97872117
137Missing ribs (HP:0000921)1.97401908
138Severe combined immunodeficiency (HP:0004430)1.96763378
139Ketosis (HP:0001946)1.95247673
140Abnormality of glycine metabolism (HP:0010895)1.93952802
141Abnormality of serine family amino acid metabolism (HP:0010894)1.93952802
142Megaloblastic anemia (HP:0001889)1.93483484
143Abnormality of DNA repair (HP:0003254)1.91919865
144Proximal placement of thumb (HP:0009623)1.91524479
145Neoplasm of striated muscle (HP:0009728)1.90831877
146Abnormality of pyrimidine metabolism (HP:0004353)1.89330716
147Optic disc pallor (HP:0000543)1.88839807
148Elevated erythrocyte sedimentation rate (HP:0003565)1.88800855
149Neoplasm of the oral cavity (HP:0100649)1.88735134
150Abnormality of homocysteine metabolism (HP:0010919)1.88435987
151Homocystinuria (HP:0002156)1.88435987
152Type II lissencephaly (HP:0007260)1.86337499
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.85652093
154Clubbing of toes (HP:0100760)1.84886159
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.83758471
156Increased muscle lipid content (HP:0009058)1.82825157
157* Neoplasm of the colon (HP:0100273)1.82052375
158Prominent nose (HP:0000448)1.80798624
159Progressive inability to walk (HP:0002505)1.80369311
160Congenital primary aphakia (HP:0007707)1.80165740
161Bony spicule pigmentary retinopathy (HP:0007737)1.79922909
162Microvesicular hepatic steatosis (HP:0001414)1.79757582
163Slender long bone (HP:0003100)1.78869844
164Abnormality of the pons (HP:0007361)1.78673917
165Deviation of the thumb (HP:0009603)1.78017619
166Renal Fanconi syndrome (HP:0001994)1.77527219
167Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77343165
168* Stomach cancer (HP:0012126)1.77190658
169Hypoplasia of the pons (HP:0012110)1.76932731
170Glioma (HP:0009733)1.76493207
171Sclerocornea (HP:0000647)1.76484902
172Respiratory failure (HP:0002878)1.75591836
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.74928608
174Hypoplasia of the fovea (HP:0007750)1.74928608
175Nephrogenic diabetes insipidus (HP:0009806)1.74888808
176Lethargy (HP:0001254)1.73779477
177Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73598389
178Amaurosis fugax (HP:0100576)1.73582438
179Leukopenia (HP:0001882)1.73520539
180Hypoplasia of the radius (HP:0002984)1.72410718
181Aplasia/Hypoplasia of the sternum (HP:0006714)1.69499153
182Acute lymphatic leukemia (HP:0006721)1.68837148
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68405776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.82907105
2MAP4K25.75425652
3WEE14.75182855
4CDC74.39078441
5VRK23.09389905
6TAOK33.00839378
7NEK22.99240768
8TSSK62.62115311
9TTK2.60327110
10EIF2AK12.56883431
11FRK2.35691796
12SRPK12.28126931
13NME22.26572398
14PLK42.21433270
15NEK12.18067031
16CDK192.13577877
17BRSK22.11216808
18PASK2.10548506
19PLK12.09555929
20NUAK12.07361266
21STK162.07153392
22ACVR1B2.02106386
23WNK31.93685238
24TRIM281.91765340
25TXK1.91280248
26VRK11.91094551
27CDK71.84570603
28PINK11.79533188
29ATR1.74447711
30AURKB1.70682010
31MUSK1.64125445
32MAP3K101.60981069
33GRK11.53636475
34TESK21.47204460
35BRSK11.46983259
36DYRK31.46101439
37CCNB11.45903727
38PLK31.43131206
39ADRBK21.42332901
40RPS6KA41.40826165
41TAF11.39886191
42MAP3K81.38965924
43CHEK21.38112629
44TLK11.38021133
45STK101.36539384
46EIF2AK31.35581008
47CDK41.34750641
48WNK41.34449894
49RPS6KB21.31917145
50TGFBR11.27879242
51AURKA1.27772780
52MKNK11.27687596
53CHEK11.22605777
54EEF2K1.18884004
55SCYL21.17070353
56MAP4K11.14872189
57CDK121.13618156
58CSNK1G31.12124011
59STK41.07398770
60CSNK1G11.07117880
61MAP3K41.02451222
62IKBKB1.01479095
63PAK41.00873029
64FLT30.99784696
65OXSR10.93737065
66BRAF0.92482058
67BMPR1B0.91427697
68MKNK20.90482442
69IKBKE0.90470050
70MAPK130.90202827
71TIE10.87717053
72CSNK1A1L0.87054770
73TNK20.85653809
74CDK20.83633873
75ATM0.82077425
76CDK80.81255616
77IRAK40.80889512
78PIM10.80618309
79GRK60.80237533
80EPHA20.79734205
81CSNK1G20.78909924
82MAP2K20.78439778
83MELK0.77022817
84TNIK0.76242382
85PIM20.75766108
86BTK0.74617926
87CLK10.74166725
88BRD40.73032496
89LRRK20.73026003
90PRKCI0.72337396
91CSNK2A20.68503537
92INSRR0.66440326
93ZAK0.66377314
94PNCK0.65975403
95CSNK2A10.65406840
96CDK10.61517259
97NME10.61254823
98PTK2B0.60981790
99SYK0.60632024
100TBK10.59806315
101CSF1R0.59505690
102ALK0.59389605
103TEC0.58450345
104MAP2K30.55800558
105PKN20.55163742
106PAK10.52417074
107MAP2K60.52116632
108BCKDK0.51503193
109MAP2K70.50673579
110KDR0.48395811
111FES0.46472676
112LCK0.46464034
113CDK60.45826189
114DAPK10.45708739
115RPS6KA50.42432571
116MST40.41551203
117EIF2AK20.41483875
118PRKCQ0.40592729
119FGFR20.40130311
120IRAK20.40093937
121MAPKAPK30.39976761
122HCK0.39143820
123DAPK20.38924070
124CSNK1A10.38120404
125AKT20.35937505
126PRKCG0.34702969
127NTRK30.34616486
128STK390.32169880
129ERBB30.31451025
130PRKDC0.30229466
131ITK0.30219816
132DYRK20.29865518
133CSNK1E0.27425842
134RAF10.26599526
135ZAP700.26317966
136STK38L0.25909392
137KIT0.24801604
138TAOK20.24010743
139RPS6KL10.22630814
140RPS6KC10.22630814
141RPS6KA60.22451705
142LYN0.21928867
143YES10.21254977
144PDK40.20651135
145PDK30.20651135
146IRAK30.19976486
147MARK30.18525784
148BLK0.15521444
149MAPK140.15401962

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.69496022
2Mismatch repair_Homo sapiens_hsa034304.84051154
3* Base excision repair_Homo sapiens_hsa034103.52295947
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52230706
5Homologous recombination_Homo sapiens_hsa034403.40900140
6Ribosome_Homo sapiens_hsa030103.37988592
7RNA polymerase_Homo sapiens_hsa030203.33524020
8Spliceosome_Homo sapiens_hsa030403.29170240
9Nucleotide excision repair_Homo sapiens_hsa034203.19289110
10Proteasome_Homo sapiens_hsa030503.14213181
11RNA transport_Homo sapiens_hsa030132.95653026
12Cell cycle_Homo sapiens_hsa041102.79666144
13Pyrimidine metabolism_Homo sapiens_hsa002402.63552808
14One carbon pool by folate_Homo sapiens_hsa006702.47383629
15Fanconi anemia pathway_Homo sapiens_hsa034602.42004777
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41874138
17Non-homologous end-joining_Homo sapiens_hsa034502.28269080
18Oxidative phosphorylation_Homo sapiens_hsa001902.18056194
19RNA degradation_Homo sapiens_hsa030181.95181069
20Basal transcription factors_Homo sapiens_hsa030221.87402705
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61869787
22mRNA surveillance pathway_Homo sapiens_hsa030151.60275708
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52260141
24p53 signaling pathway_Homo sapiens_hsa041151.46282328
25Purine metabolism_Homo sapiens_hsa002301.42372711
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39615110
27Phototransduction_Homo sapiens_hsa047441.33349515
28Butanoate metabolism_Homo sapiens_hsa006501.33136140
29Linoleic acid metabolism_Homo sapiens_hsa005911.28183059
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26694626
31Fatty acid elongation_Homo sapiens_hsa000621.26517506
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.21487942
33Epstein-Barr virus infection_Homo sapiens_hsa051691.19443312
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19031263
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15175533
36Asthma_Homo sapiens_hsa053101.11875103
37Propanoate metabolism_Homo sapiens_hsa006401.11687290
38Peroxisome_Homo sapiens_hsa041461.06921643
39Regulation of autophagy_Homo sapiens_hsa041401.04844456
40Ether lipid metabolism_Homo sapiens_hsa005651.01345567
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98922912
42Graft-versus-host disease_Homo sapiens_hsa053320.98462250
43Oocyte meiosis_Homo sapiens_hsa041140.94241853
44Autoimmune thyroid disease_Homo sapiens_hsa053200.93530439
45Type I diabetes mellitus_Homo sapiens_hsa049400.93402931
46Biosynthesis of amino acids_Homo sapiens_hsa012300.92918403
47Tryptophan metabolism_Homo sapiens_hsa003800.90753149
48Pentose phosphate pathway_Homo sapiens_hsa000300.89812359
49Folate biosynthesis_Homo sapiens_hsa007900.86563518
50Primary immunodeficiency_Homo sapiens_hsa053400.86556765
51Herpes simplex infection_Homo sapiens_hsa051680.86424515
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.86405998
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85941523
54Nitrogen metabolism_Homo sapiens_hsa009100.84750065
55Vitamin B6 metabolism_Homo sapiens_hsa007500.84605133
56Antigen processing and presentation_Homo sapiens_hsa046120.83825748
57Systemic lupus erythematosus_Homo sapiens_hsa053220.83823240
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82541875
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82205596
60Caffeine metabolism_Homo sapiens_hsa002320.81385781
61Alzheimers disease_Homo sapiens_hsa050100.81200635
62Viral carcinogenesis_Homo sapiens_hsa052030.77645383
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.76599684
64Steroid biosynthesis_Homo sapiens_hsa001000.76372101
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75482268
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73404610
67HTLV-I infection_Homo sapiens_hsa051660.71632892
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.70380450
69Selenocompound metabolism_Homo sapiens_hsa004500.70208259
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66650907
71Taste transduction_Homo sapiens_hsa047420.64330927
72Arachidonic acid metabolism_Homo sapiens_hsa005900.59809819
73Sulfur relay system_Homo sapiens_hsa041220.59358308
74Thyroid cancer_Homo sapiens_hsa052160.58993336
75Fatty acid metabolism_Homo sapiens_hsa012120.56473553
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.53745059
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53546364
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52594782
79Carbon metabolism_Homo sapiens_hsa012000.52516109
80Protein export_Homo sapiens_hsa030600.52197274
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51010517
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47494133
83Huntingtons disease_Homo sapiens_hsa050160.47231379
84Chemical carcinogenesis_Homo sapiens_hsa052040.46908795
85Fructose and mannose metabolism_Homo sapiens_hsa000510.46894158
86Fat digestion and absorption_Homo sapiens_hsa049750.45356815
87MicroRNAs in cancer_Homo sapiens_hsa052060.44716802
88Arginine and proline metabolism_Homo sapiens_hsa003300.44578702
89Legionellosis_Homo sapiens_hsa051340.43905127
90Small cell lung cancer_Homo sapiens_hsa052220.43398921
91Retinol metabolism_Homo sapiens_hsa008300.40827571
92beta-Alanine metabolism_Homo sapiens_hsa004100.39717077
93Pyruvate metabolism_Homo sapiens_hsa006200.39017360
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38711951
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38343734
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38007711
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37786554
98Glutathione metabolism_Homo sapiens_hsa004800.36267372
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36184421
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35176399
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34907377
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33561887
103Apoptosis_Homo sapiens_hsa042100.33442185
104Vitamin digestion and absorption_Homo sapiens_hsa049770.33290436
105Fatty acid degradation_Homo sapiens_hsa000710.31670380
106Measles_Homo sapiens_hsa051620.31151503
107ABC transporters_Homo sapiens_hsa020100.30521816
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30451019
109Colorectal cancer_Homo sapiens_hsa052100.29701793
110Notch signaling pathway_Homo sapiens_hsa043300.28790063
111Basal cell carcinoma_Homo sapiens_hsa052170.25869488
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.25848121
113Parkinsons disease_Homo sapiens_hsa050120.24751332
114Hepatitis B_Homo sapiens_hsa051610.23199554
115Alcoholism_Homo sapiens_hsa050340.22099068
116Shigellosis_Homo sapiens_hsa051310.21772852
117TGF-beta signaling pathway_Homo sapiens_hsa043500.21423933
118N-Glycan biosynthesis_Homo sapiens_hsa005100.20148104
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19824569
120HIF-1 signaling pathway_Homo sapiens_hsa040660.19796631
121Galactose metabolism_Homo sapiens_hsa000520.18497423
122Metabolic pathways_Homo sapiens_hsa011000.18477284
123Hippo signaling pathway_Homo sapiens_hsa043900.17787806
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.16779790
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.16533233
126Pathways in cancer_Homo sapiens_hsa052000.15814582
127Influenza A_Homo sapiens_hsa051640.15537548
128Acute myeloid leukemia_Homo sapiens_hsa052210.13819270
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13764512
130Chronic myeloid leukemia_Homo sapiens_hsa052200.12592860
131Hedgehog signaling pathway_Homo sapiens_hsa043400.10626939
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10062156
133Bladder cancer_Homo sapiens_hsa052190.10042449
134B cell receptor signaling pathway_Homo sapiens_hsa046620.09585048
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09173850
136Non-small cell lung cancer_Homo sapiens_hsa052230.08685127
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08366156
138Viral myocarditis_Homo sapiens_hsa054160.08078635
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07826602
140Hematopoietic cell lineage_Homo sapiens_hsa046400.06709903
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05996677
142Lysine degradation_Homo sapiens_hsa003100.05137619
143T cell receptor signaling pathway_Homo sapiens_hsa046600.01658949
144mTOR signaling pathway_Homo sapiens_hsa041500.01419077
145Allograft rejection_Homo sapiens_hsa053300.01180101

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