MVD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)9.88933993
2* sterol biosynthetic process (GO:0016126)9.19531890
3axon ensheathment in central nervous system (GO:0032291)9.01900054
4central nervous system myelination (GO:0022010)9.01900054
5* isoprenoid biosynthetic process (GO:0008299)6.92980535
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.46554839
7low-density lipoprotein particle clearance (GO:0034383)6.16243418
8ensheathment of neurons (GO:0007272)6.10337738
9axon ensheathment (GO:0008366)6.10337738
10long-chain fatty acid biosynthetic process (GO:0042759)6.05994988
11myelination (GO:0042552)5.98690723
12fatty-acyl-CoA biosynthetic process (GO:0046949)5.80163484
13regulation of cholesterol homeostasis (GO:2000188)5.79789038
14long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.68591620
15regulation of cholesterol biosynthetic process (GO:0045540)5.53237767
16proline biosynthetic process (GO:0006561)5.47085538
17establishment of mitochondrion localization (GO:0051654)5.42441182
18Golgi transport vesicle coating (GO:0048200)5.15896081
19COPI coating of Golgi vesicle (GO:0048205)5.15896081
20fatty-acyl-CoA metabolic process (GO:0035337)5.06775298
21amyloid precursor protein metabolic process (GO:0042982)4.96930007
22thioester biosynthetic process (GO:0035384)4.93601612
23acyl-CoA biosynthetic process (GO:0071616)4.93601612
24response to lipoprotein particle (GO:0055094)4.88440130
25proline metabolic process (GO:0006560)4.62355579
26amyloid precursor protein catabolic process (GO:0042987)4.60699354
27regulation of collateral sprouting (GO:0048670)4.50586342
28response to methylmercury (GO:0051597)4.49556241
29substantia nigra development (GO:0021762)4.48360312
30tricarboxylic acid metabolic process (GO:0072350)4.44983937
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.39993875
32myelin maintenance (GO:0043217)4.25493753
33glucose 6-phosphate metabolic process (GO:0051156)4.24161849
34very long-chain fatty acid metabolic process (GO:0000038)4.24063278
35* cholesterol metabolic process (GO:0008203)4.21386210
36positive regulation of actin filament depolymerization (GO:0030836)4.20708395
37plasma lipoprotein particle clearance (GO:0034381)4.20552554
38intestinal cholesterol absorption (GO:0030299)4.07216748
39protein retention in ER lumen (GO:0006621)4.01934831
40glycerophospholipid catabolic process (GO:0046475)4.01526650
41linoleic acid metabolic process (GO:0043651)4.00856694
42* alcohol biosynthetic process (GO:0046165)3.92273269
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91374846
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.88240164
45regulation of cholesterol storage (GO:0010885)3.86589328
46peptidyl-arginine omega-N-methylation (GO:0035247)3.86515386
47L-serine metabolic process (GO:0006563)3.86372598
48NADPH regeneration (GO:0006740)3.83832132
49creatine metabolic process (GO:0006600)3.82940070
50* sterol metabolic process (GO:0016125)3.81687503
51regulation of cholesterol metabolic process (GO:0090181)3.79083003
52plasma lipoprotein particle assembly (GO:0034377)3.78588547
53very-low-density lipoprotein particle assembly (GO:0034379)3.77205718
54* steroid biosynthetic process (GO:0006694)3.76797121
55pyrimidine nucleobase catabolic process (GO:0006208)3.70038696
56negative regulation of cholesterol transport (GO:0032375)3.66511509
57negative regulation of sterol transport (GO:0032372)3.66511509
58oligodendrocyte differentiation (GO:0048709)3.63048414
59protein-lipid complex assembly (GO:0065005)3.62874144
60establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.57517723
61mitochondrion transport along microtubule (GO:0047497)3.57517723
62protein insertion into membrane (GO:0051205)3.53259393
63detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.51618518
64detection of temperature stimulus involved in sensory perception (GO:0050961)3.51618518
65serine transport (GO:0032329)3.50348934
66protein carboxylation (GO:0018214)3.48099636
67peptidyl-glutamic acid carboxylation (GO:0017187)3.48099636
68negative regulation of neurotransmitter secretion (GO:0046929)3.46994360
69pentose-phosphate shunt (GO:0006098)3.42970692
70* thioester metabolic process (GO:0035383)3.41042450
71* acyl-CoA metabolic process (GO:0006637)3.41042450
72adhesion of symbiont to host cell (GO:0044650)3.39871435
73virion attachment to host cell (GO:0019062)3.39871435
74negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.39863619
75terpenoid biosynthetic process (GO:0016114)3.38573011
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.37370001
77layer formation in cerebral cortex (GO:0021819)3.36378433
78apical protein localization (GO:0045176)3.33860143
79L-serine transport (GO:0015825)3.29158814
80oxaloacetate metabolic process (GO:0006107)3.28595070
81fatty acid homeostasis (GO:0055089)3.27780942
82negative regulation of neurotransmitter transport (GO:0051589)3.27444571
83aldehyde catabolic process (GO:0046185)3.26612733
84glucose catabolic process (GO:0006007)3.25674040
85NADH metabolic process (GO:0006734)3.24688817
86triglyceride biosynthetic process (GO:0019432)3.24363118
87glyoxylate metabolic process (GO:0046487)3.22780036
88cellular response to cholesterol (GO:0071397)3.22071478
89L-phenylalanine catabolic process (GO:0006559)3.21832873
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.21832873
91GDP-mannose metabolic process (GO:0019673)3.21613196
92response to follicle-stimulating hormone (GO:0032354)3.20405515
93regulation of translational fidelity (GO:0006450)3.19004097
94cell-cell junction maintenance (GO:0045217)3.18311190
95peptidyl-arginine N-methylation (GO:0035246)3.14642659
96peptidyl-arginine methylation (GO:0018216)3.14642659
97positive regulation of cellular amine metabolic process (GO:0033240)3.13572714
98negative regulation of fibrinolysis (GO:0051918)3.13171637
99regulation of cholesterol esterification (GO:0010872)3.13047613
100histone arginine methylation (GO:0034969)3.10821773
101coenzyme A metabolic process (GO:0015936)3.10211050
102cellular modified amino acid catabolic process (GO:0042219)3.09676071
103monosaccharide biosynthetic process (GO:0046364)3.09020314
104peptidyl-cysteine modification (GO:0018198)3.08917766
105regulation of early endosome to late endosome transport (GO:2000641)3.06828709
106* acetyl-CoA metabolic process (GO:0006084)3.04858325
107protein neddylation (GO:0045116)3.04722152
108positive regulation of pseudopodium assembly (GO:0031274)3.04713344
109heme transport (GO:0015886)3.04616143
110response to redox state (GO:0051775)3.04534188
111regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04011578
112neutral lipid biosynthetic process (GO:0046460)3.00458505
113acylglycerol biosynthetic process (GO:0046463)3.00458505
114positive regulation of oligodendrocyte differentiation (GO:0048714)3.00372309
115asymmetric protein localization (GO:0008105)2.99799227
116myelination in peripheral nervous system (GO:0022011)2.98929811
117peripheral nervous system axon ensheathment (GO:0032292)2.98929811
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97870550
119L-phenylalanine metabolic process (GO:0006558)2.97870550
120biotin metabolic process (GO:0006768)2.97445524
121astrocyte development (GO:0014002)2.95410603
122coenzyme catabolic process (GO:0009109)2.94868151
123neural nucleus development (GO:0048857)2.94641224
124glutamine family amino acid biosynthetic process (GO:0009084)2.93902731
125glutathione biosynthetic process (GO:0006750)2.93755353
126gluconeogenesis (GO:0006094)2.92830866
127coenzyme A biosynthetic process (GO:0015937)2.92529739
128negative regulation of axonogenesis (GO:0050771)2.92298949
129regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.92222091
130serine family amino acid biosynthetic process (GO:0009070)2.91313753
131chaperone-mediated protein transport (GO:0072321)2.91062854
132iron coordination entity transport (GO:1901678)2.91032966
133enteric nervous system development (GO:0048484)2.89966848
134diacylglycerol metabolic process (GO:0046339)2.88708023
135cholesterol efflux (GO:0033344)2.86226487
136estrogen biosynthetic process (GO:0006703)2.85347493
137receptor catabolic process (GO:0032801)2.84507975
138axon development (GO:0061564)2.83362859
139glycolytic process (GO:0006096)2.82762627
140regulation of lipoprotein metabolic process (GO:0050746)2.82669516
141hemidesmosome assembly (GO:0031581)2.82138555
142mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82035612
143positive regulation of fatty acid biosynthetic process (GO:0045723)2.81231483
144pyrimidine-containing compound transmembrane transport (GO:0072531)2.80394849
145positive regulation of triglyceride biosynthetic process (GO:0010867)2.79971058
146protein palmitoylation (GO:0018345)2.79933043
147alpha-linolenic acid metabolic process (GO:0036109)2.79877894
148hexose biosynthetic process (GO:0019319)2.78812947
149nucleobase catabolic process (GO:0046113)2.78766564
150fatty acid biosynthetic process (GO:0006633)2.77517025
151L-amino acid import (GO:0043092)2.74765632
152mitotic nuclear envelope reassembly (GO:0007084)2.74481188
153nuclear envelope reassembly (GO:0031468)2.74481188
154cellular response to hepatocyte growth factor stimulus (GO:0035729)2.74319954
155response to hepatocyte growth factor (GO:0035728)2.74319954
156detection of temperature stimulus (GO:0016048)2.73049577
157regulation of extracellular matrix disassembly (GO:0010715)2.72946918
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72871630
159negative regulation of fatty acid biosynthetic process (GO:0045717)2.71887423
160response to phenylpropanoid (GO:0080184)2.71329129
161* organic hydroxy compound biosynthetic process (GO:1901617)2.70558738
162ATP synthesis coupled proton transport (GO:0015986)2.70532249
163regulation of triglyceride biosynthetic process (GO:0010866)2.69177573
1644-hydroxyproline metabolic process (GO:0019471)2.66706305
165regulation of apoptotic cell clearance (GO:2000425)2.66697477
166maternal placenta development (GO:0001893)2.65595172
167positive regulation of lipid storage (GO:0010884)2.65476581
168response to vitamin A (GO:0033189)2.65159989
169positive regulation of lipoprotein lipase activity (GO:0051006)2.62334287
170positive regulation of triglyceride lipase activity (GO:0061365)2.62334287
171phospholipid efflux (GO:0033700)2.61522760
172positive regulation of nuclease activity (GO:0032075)2.61119327
1732-oxoglutarate metabolic process (GO:0006103)2.61086526
174adenine nucleotide transport (GO:0051503)2.60168242
175* cholesterol biosynthetic process (GO:0006695)10.4698793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.74662962
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.20501465
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.98363405
4* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73000379
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70486247
6CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47958852
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46193036
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42674765
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42650657
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.31935797
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26888129
12MYC_22102868_ChIP-Seq_BL_Human2.23492561
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04085827
14VDR_21846776_ChIP-Seq_THP-1_Human2.03888847
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02698047
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98853316
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.96999477
18ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.96813142
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.90283378
20ZNF263_19887448_ChIP-Seq_K562_Human1.89599323
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.83091806
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81639619
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.80426273
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80170220
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80170220
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80170220
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.78526736
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71731147
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70654932
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68868668
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.67502832
32EOMES_21245162_ChIP-Seq_HESCs_Human1.66706155
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65991714
34* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65681756
35P68_20966046_ChIP-Seq_HELA_Human1.63608628
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59018424
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57885091
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56724347
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.55754948
40* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55185200
41SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.53861763
42SOX17_20123909_ChIP-Seq_XEN_Mouse1.52554663
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52299850
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.51185756
45SOX2_18692474_ChIP-Seq_MEFs_Mouse1.51006008
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47901312
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47633082
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47401086
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47166002
50NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46318263
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44039996
52KDM2B_26808549_Chip-Seq_K562_Human1.43516845
53KDM2B_26808549_Chip-Seq_DND41_Human1.42903680
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42055824
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41736948
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.40963427
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40696411
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40042028
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39743361
60* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36506897
61SMC4_20622854_ChIP-Seq_HELA_Human1.33127368
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32800123
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.31880862
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31502070
65NCOR1_26117541_ChIP-Seq_K562_Human1.30952789
66CTCF_20526341_ChIP-Seq_ESCs_Human1.30803540
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30552061
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26793155
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.26694270
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26150725
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25966622
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25764446
73TCF7_22412390_ChIP-Seq_EML_Mouse1.25452061
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24795794
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24614220
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.24438337
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24405684
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23678998
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23481996
80* CLOCK_20551151_ChIP-Seq_293T_Human1.23317727
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23166171
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22676436
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22252514
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21858663
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21274204
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.20843955
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20649261
88STAT1_20625510_ChIP-Seq_HELA_Human1.19134729
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17154107
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16968357
91CREB1_26743006_Chip-Seq_LNCaP_Human1.16583492
92RARA_24833708_ChIP-Seq_LIVER_Mouse1.16442306
93ATF3_27146783_Chip-Seq_COLON_Human1.16431694
94TP53_22127205_ChIP-Seq_IMR90_Human1.15885701
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.13046716
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12407696
97XRN2_22483619_ChIP-Seq_HELA_Human1.11736350
98BCOR_27268052_Chip-Seq_Bcells_Human1.11159924
99* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11037226
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10416523
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.09519767
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.09411217
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08052922
104GABP_19822575_ChIP-Seq_HepG2_Human1.07661090
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07395952
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07361721
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07137980
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06918349
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.06257789
110PHF8_20622854_ChIP-Seq_HELA_Human1.05048348
111* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04988145
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04826084
113BCL6_27268052_Chip-Seq_Bcells_Human1.04737908
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04219444
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04049549
116SOX2_20726797_ChIP-Seq_SW620_Human1.02825695
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02638894
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02587807
119KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01887642
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01047203
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00750886
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.00700850
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00056232
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99222537
125JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98179558
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97641091
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96895043
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96751392
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95859403
130ER_23166858_ChIP-Seq_MCF-7_Human0.95335093
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94701904
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93157015
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93102289
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.92459307
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.92007555
136E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91834846
137EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91483058
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90977698
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90947630
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90531867
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.89972934
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.88596683
143SA1_27219007_Chip-Seq_Bcells_Human0.87883687
144ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86939227
145SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86423656
146HTT_18923047_ChIP-ChIP_STHdh_Human0.85748894
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85104582
148RACK7_27058665_Chip-Seq_MCF-7_Human0.84688943
149EZH2_27294783_Chip-Seq_ESCs_Mouse0.84297291
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84235125
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84235125
152NCOR_22424771_ChIP-Seq_293T_Human0.82292174
153LXR_22292898_ChIP-Seq_THP-1_Human0.81795088
154* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81482820
155POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81334808
156SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81130258
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80882024
158NANOG_18692474_ChIP-Seq_MESCs_Mouse0.80266851
159GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79872305
160NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79411033
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79174483
162KLF5_25053715_ChIP-Seq_YYC3_Human0.79147681
163CTCF_27219007_Chip-Seq_Bcells_Human0.78762402
164DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78207335
165CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76727390
166AR_21572438_ChIP-Seq_LNCaP_Human0.76520635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.17447258
2MP0003806_abnormal_nucleotide_metabolis4.18228259
3MP0003329_amyloid_beta_deposits4.00291948
4MP0003122_maternal_imprinting3.15169501
5MP0003690_abnormal_glial_cell3.02808056
6MP0001529_abnormal_vocalization2.95044426
7MP0005451_abnormal_body_composition2.90521860
8MP0005083_abnormal_biliary_tract2.79317753
9MP0002139_abnormal_hepatobiliary_system2.78882737
10MP0000566_synostosis2.77556600
11MP0009840_abnormal_foam_cell2.69644308
12MP0000778_abnormal_nervous_system2.59775618
13MP0003705_abnormal_hypodermis_morpholog2.56169599
14MP0010234_abnormal_vibrissa_follicle2.53297174
15MP0001905_abnormal_dopamine_level2.47796044
16MP0003634_abnormal_glial_cell2.47166896
17MP0000604_amyloidosis2.46455048
18MP0004270_analgesia2.46387413
19MP0003136_yellow_coat_color2.40369552
20MP0005360_urolithiasis2.26365453
21MP0004885_abnormal_endolymph2.21765032
22MP0003632_abnormal_nervous_system2.08758266
23MP0000579_abnormal_nail_morphology2.06193942
24MP0000462_abnormal_digestive_system2.03792917
25MP0004742_abnormal_vestibular_system2.02590460
26MP0004142_abnormal_muscle_tone2.01918783
27MP0009672_abnormal_birth_weight2.01861022
28MP0010329_abnormal_lipoprotein_level2.00533281
29MP0005365_abnormal_bile_salt1.93807790
30MP0001348_abnormal_lacrimal_gland1.89163692
31MP0003123_paternal_imprinting1.87853694
32MP0003880_abnormal_central_pattern1.86294562
33MP0000678_abnormal_parathyroid_gland1.84306507
34MP0003011_delayed_dark_adaptation1.80975438
35MP0003950_abnormal_plasma_membrane1.79934104
36MP0005171_absent_coat_pigmentation1.79878814
37MP0001485_abnormal_pinna_reflex1.74741177
38MP0005076_abnormal_cell_differentiation1.70526911
39MP0002254_reproductive_system_inflammat1.69475810
40MP0003566_abnormal_cell_adhesion1.63419116
41MP0004134_abnormal_chest_morphology1.61749587
42MP0003195_calcinosis1.51711390
43MP0000372_irregular_coat_pigmentation1.48835694
44MP0004264_abnormal_extraembryonic_tissu1.44788273
45MP0005408_hypopigmentation1.44322802
46MP0000609_abnormal_liver_physiology1.39097065
47MP0005257_abnormal_intraocular_pressure1.37064574
48MP0002098_abnormal_vibrissa_morphology1.36734353
49MP0002229_neurodegeneration1.34319762
50MP0002295_abnormal_pulmonary_circulatio1.34171026
51MP0000003_abnormal_adipose_tissue1.33700350
52MP0000647_abnormal_sebaceous_gland1.32711490
53MP0000955_abnormal_spinal_cord1.31300742
54MP0003718_maternal_effect1.30500547
55MP0002733_abnormal_thermal_nociception1.29556907
56MP0004859_abnormal_synaptic_plasticity1.29530570
57MP0001661_extended_life_span1.27749000
58MP0004272_abnormal_basement_membrane1.27576231
59MP0005332_abnormal_amino_acid1.27138601
60MP0002734_abnormal_mechanical_nocicepti1.26568883
61MP0001299_abnormal_eye_distance/1.25298806
62MP0002796_impaired_skin_barrier1.23298207
63MP0010678_abnormal_skin_adnexa1.22463813
64MP0006082_CNS_inflammation1.21902965
65MP0003300_gastrointestinal_ulcer1.21245447
66MP0005666_abnormal_adipose_tissue1.20849507
67MP0003191_abnormal_cellular_cholesterol1.20238060
68MP0005058_abnormal_lysosome_morphology1.18768271
69MP0004381_abnormal_hair_follicle1.15593133
70MP0001440_abnormal_grooming_behavior1.14779203
71MP0003938_abnormal_ear_development1.14523419
72MP0002970_abnormal_white_adipose1.13641410
73MP0005375_adipose_tissue_phenotype1.13367502
74MP0001730_embryonic_growth_arrest1.13067153
75MP0004185_abnormal_adipocyte_glucose1.12390528
76MP0008438_abnormal_cutaneous_collagen1.12091472
77MP0001216_abnormal_epidermal_layer1.10384578
78MP0008260_abnormal_autophagy1.09071323
79MP0002882_abnormal_neuron_morphology1.08500146
80MP0004233_abnormal_muscle_weight1.08229623
81MP0003631_nervous_system_phenotype1.08224668
82MP0002735_abnormal_chemical_nociception1.07155511
83MP0003315_abnormal_perineum_morphology1.07023625
84MP0005085_abnormal_gallbladder_physiolo1.05786115
85MP0002272_abnormal_nervous_system1.05450649
86MP0005499_abnormal_olfactory_system1.04526531
87MP0005394_taste/olfaction_phenotype1.04526531
88MP0002118_abnormal_lipid_homeostasis1.03460905
89MP0001915_intracranial_hemorrhage1.03415227
90MP0001486_abnormal_startle_reflex1.02962691
91MP0005584_abnormal_enzyme/coenzyme_acti1.02115760
92MP0000858_altered_metastatic_potential1.01452379
93MP0004133_heterotaxia1.01028332
94MP0002064_seizures0.98403304
95MP0002752_abnormal_somatic_nervous0.98251966
96MP0009384_cardiac_valve_regurgitation0.98246484
97MP0008875_abnormal_xenobiotic_pharmacok0.98045722
98MP0005423_abnormal_somatic_nervous0.97968672
99MP0003941_abnormal_skin_development0.97517422
100MP0004947_skin_inflammation0.96975111
101MP0002249_abnormal_larynx_morphology0.96817347
102MP0003937_abnormal_limbs/digits/tail_de0.96687351
103MP0003111_abnormal_nucleus_morphology0.95630205
104MP0000747_muscle_weakness0.95185940
105MP0005195_abnormal_posterior_eye0.94140884
106MP0002066_abnormal_motor_capabilities/c0.94052756
107MP0000383_abnormal_hair_follicle0.93199361
108MP0001970_abnormal_pain_threshold0.92863072
109MP0009931_abnormal_skin_appearance0.92817552
110MP0004858_abnormal_nervous_system0.91148524
111MP0001346_abnormal_lacrimal_gland0.89969369
112MP0000762_abnormal_tongue_morphology0.89388968
113MP0002938_white_spotting0.87945582
114MP0000537_abnormal_urethra_morphology0.85177599
115MP0002152_abnormal_brain_morphology0.84792893
116MP0001340_abnormal_eyelid_morphology0.83585878
117MP0005670_abnormal_white_adipose0.82174687
118MP0001727_abnormal_embryo_implantation0.81936786
119MP0003221_abnormal_cardiomyocyte_apopto0.81709716
120MP0003861_abnormal_nervous_system0.80795444
121MP0000467_abnormal_esophagus_morphology0.79915445
122MP0002080_prenatal_lethality0.78734210
123MP0001666_abnormal_nutrient_absorption0.78303120
124MP0000598_abnormal_liver_morphology0.77980715
125MP0005409_darkened_coat_color0.77782092
126MP0002751_abnormal_autonomic_nervous0.77637797
127MP0003186_abnormal_redox_activity0.77228342
128MP0002090_abnormal_vision0.76899800
129MP0005623_abnormal_meninges_morphology0.76716705
130MP0002971_abnormal_brown_adipose0.75947909
131MP0001881_abnormal_mammary_gland0.75677239
132MP0002653_abnormal_ependyma_morphology0.74129466
133MP0009278_abnormal_bone_marrow0.74010134
134MP0001849_ear_inflammation0.73537546
135MP0000751_myopathy0.73459999
136MP0003115_abnormal_respiratory_system0.73022516
137MP0003942_abnormal_urinary_system0.72353551
138MP0000377_abnormal_hair_follicle0.71226061
139MP0005410_abnormal_fertilization0.71100479
140MP0003656_abnormal_erythrocyte_physiolo0.71089706
141MP0002089_abnormal_postnatal_growth/wei0.70989319
142MP0003453_abnormal_keratinocyte_physiol0.70405186
143MP0001963_abnormal_hearing_physiology0.70296193
144MP0002822_catalepsy0.69631680
145MP0005501_abnormal_skin_physiology0.69124966
146MP0009703_decreased_birth_body0.68655088
147MP0005334_abnormal_fat_pad0.67640723
148MP0009379_abnormal_foot_pigmentation0.67501424
149MP0003693_abnormal_embryo_hatching0.66586096
150MP0003121_genomic_imprinting0.66445448
151MP0008932_abnormal_embryonic_tissue0.65225566
152MP0004197_abnormal_fetal_growth/weight/0.63825582
153MP0010030_abnormal_orbit_morphology0.61745153
154MP0002111_abnormal_tail_morphology0.61567407
155MP0003385_abnormal_body_wall0.60976244
156MP0003172_abnormal_lysosome_physiology0.60923087
157MP0002092_abnormal_eye_morphology0.60057316
158MP0000750_abnormal_muscle_regeneration0.59557757
159MP0003948_abnormal_gas_homeostasis0.59063221
160MP0002736_abnormal_nociception_after0.58750121
161MP0001672_abnormal_embryogenesis/_devel0.58474000
162MP0005380_embryogenesis_phenotype0.58474000

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)6.39119819
2Increased serum pyruvate (HP:0003542)6.39119819
3Parakeratosis (HP:0001036)6.10211748
4Neurofibrillary tangles (HP:0002185)5.97031210
5Degeneration of the lateral corticospinal tracts (HP:0002314)5.29315688
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.29315688
7Cerebral inclusion bodies (HP:0100314)4.83688964
8Abnormality of the corticospinal tract (HP:0002492)4.53721383
9Sensory axonal neuropathy (HP:0003390)4.17169457
10Hypoplastic pelvis (HP:0008839)4.05952428
11Cerebral hypomyelination (HP:0006808)4.01932610
12Congenital ichthyosiform erythroderma (HP:0007431)3.94636314
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.76248167
14Reticulocytosis (HP:0001923)3.67462384
15Peripheral hypomyelination (HP:0007182)3.59091431
16Insidious onset (HP:0003587)3.53101410
17Termporal pattern (HP:0011008)3.53101410
18Spastic paraparesis (HP:0002313)3.41635967
19Akinesia (HP:0002304)3.36596137
20Supranuclear gaze palsy (HP:0000605)3.29038125
21Hemorrhage of the eye (HP:0011885)3.28708820
22Partial agenesis of the corpus callosum (HP:0001338)3.22369423
23Hyperacusis (HP:0010780)3.16435343
24Leukodystrophy (HP:0002415)3.14622226
25Stridor (HP:0010307)3.12239057
26Broad alveolar ridges (HP:0000187)2.96407559
27Insomnia (HP:0100785)2.90091846
28Hypercholesterolemia (HP:0003124)2.89306116
29Spastic gait (HP:0002064)2.79302602
30Anomalous pulmonary venous return (HP:0010772)2.77557192
31Achilles tendon contracture (HP:0001771)2.76980881
32Onion bulb formation (HP:0003383)2.71840915
33Abnormality of the Achilles tendon (HP:0005109)2.69636732
34Myelomeningocele (HP:0002475)2.59763207
35Upper limb amyotrophy (HP:0009129)2.54829824
36Distal upper limb amyotrophy (HP:0007149)2.54829824
37Long palpebral fissure (HP:0000637)2.52542358
38Cortical dysplasia (HP:0002539)2.51894293
39Abnormality of reticulocytes (HP:0004312)2.49827120
40Abnormality of the gallbladder (HP:0005264)2.41321071
41Truncus arteriosus (HP:0001660)2.39623642
42Hepatosplenomegaly (HP:0001433)2.39611135
43Adrenal hypoplasia (HP:0000835)2.38926531
44Morphological abnormality of the pyramidal tract (HP:0002062)2.38840138
45Cerebral hemorrhage (HP:0001342)2.35483145
46Overlapping toe (HP:0001845)2.34418656
47Paraparesis (HP:0002385)2.34100138
48Abnormality of the pulmonary veins (HP:0011718)2.34060055
49Abnormal auditory evoked potentials (HP:0006958)2.32324161
50Cholelithiasis (HP:0001081)2.31242097
51Generalized hypotonia (HP:0001290)2.31040057
52Xanthomatosis (HP:0000991)2.30204962
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29266821
54Intrahepatic cholestasis (HP:0001406)2.28631708
55Fragile nails (HP:0001808)2.28319288
56Hand muscle atrophy (HP:0009130)2.27421549
57Segmental peripheral demyelination/remyelination (HP:0003481)2.25263873
58Abnormality of nail color (HP:0100643)2.24104561
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23775581
60Renal duplication (HP:0000075)2.22722176
61Facial hemangioma (HP:0000329)2.21022351
62Pheochromocytoma (HP:0002666)2.20494663
63Biconcave vertebral bodies (HP:0004586)2.19702179
64Intention tremor (HP:0002080)2.18894822
65Small epiphyses (HP:0010585)2.18343290
66Vertebral compression fractures (HP:0002953)2.15992825
67Abnormality of placental membranes (HP:0011409)2.15983822
68Amniotic constriction ring (HP:0009775)2.15983822
69Coronal craniosynostosis (HP:0004440)2.15339668
70Alacrima (HP:0000522)2.15278202
71Ankle clonus (HP:0011448)2.13818998
72Slow saccadic eye movements (HP:0000514)2.13327723
73Relative macrocephaly (HP:0004482)2.10043351
74Abnormal gallbladder morphology (HP:0012437)2.09751215
75Advanced eruption of teeth (HP:0006288)2.08135054
76Disproportionate tall stature (HP:0001519)2.08124064
77CNS hypomyelination (HP:0003429)2.07121173
78Multiple enchondromatosis (HP:0005701)2.05186608
79Large earlobe (HP:0009748)2.04102461
80Seborrheic dermatitis (HP:0001051)2.02525784
81Self-mutilation (HP:0000742)2.02315730
82Ulnar bowing (HP:0003031)2.01930324
83Neonatal onset (HP:0003623)2.01177982
84Hyperthyroidism (HP:0000836)2.00740483
85Axonal loss (HP:0003447)2.00326288
86Hypertensive crisis (HP:0100735)1.99146868
87Erythroderma (HP:0001019)1.98260006
88Premature skin wrinkling (HP:0100678)1.98102830
89Back pain (HP:0003418)1.97401935
90Neonatal death (HP:0003811)1.95767806
91Neuroendocrine neoplasm (HP:0100634)1.95622080
92Renovascular hypertension (HP:0100817)1.94515950
93Aplasia of the musculature (HP:0100854)1.92990831
94Diminished movement (HP:0002374)1.92977502
95Pointed chin (HP:0000307)1.92447193
96Ileus (HP:0002595)1.92207384
97Breech presentation (HP:0001623)1.91765914
98Absent septum pellucidum (HP:0001331)1.90739798
99Hypophosphatemic rickets (HP:0004912)1.89543727
100Myocardial infarction (HP:0001658)1.89185004
101Renal Fanconi syndrome (HP:0001994)1.87649923
102Bronchomalacia (HP:0002780)1.87602077
103Autoamputation (HP:0001218)1.87317113
104Retinal dysplasia (HP:0007973)1.87086448
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87017629
106Premature rupture of membranes (HP:0001788)1.86199400
107Abnormality of the fetal cardiovascular system (HP:0010948)1.85556356
108Abnormal umbilical cord blood vessels (HP:0011403)1.85556356
109Single umbilical artery (HP:0001195)1.85556356
110Acute encephalopathy (HP:0006846)1.85378598
111Morphological abnormality of the inner ear (HP:0011390)1.84884820
112Stenosis of the external auditory canal (HP:0000402)1.83698952
113Hammertoe (HP:0001765)1.83641263
114Vertebral clefting (HP:0008428)1.83424329
115Deep venous thrombosis (HP:0002625)1.83333787
116Acanthosis nigricans (HP:0000956)1.83145035
117Neuronal loss in central nervous system (HP:0002529)1.83060906
118Abnormality of the alveolar ridges (HP:0006477)1.82860943
119Peritonitis (HP:0002586)1.82199213
120Elfin facies (HP:0004428)1.81985624
121Nonimmune hydrops fetalis (HP:0001790)1.81760854
122Prolonged partial thromboplastin time (HP:0003645)1.81237027
123Methylmalonic acidemia (HP:0002912)1.81156812
124Bowel incontinence (HP:0002607)1.80120389
125Increased nuchal translucency (HP:0010880)1.79486530
126Acute necrotizing encephalopathy (HP:0006965)1.79366305
127Microglossia (HP:0000171)1.79311133
128Dysmetria (HP:0001310)1.79232518
129Postnatal microcephaly (HP:0005484)1.78991443
130Polycythemia (HP:0001901)1.78836761
131Meningocele (HP:0002435)1.78559331
132Abnormality of the parathyroid morphology (HP:0011766)1.78280025
133Onycholysis (HP:0001806)1.77948848
134Prolonged neonatal jaundice (HP:0006579)1.77072293
135Overriding aorta (HP:0002623)1.76517617
136Hypobetalipoproteinemia (HP:0003563)1.75892700
137Joint hemorrhage (HP:0005261)1.75563987
138Cupped ear (HP:0000378)1.74230873
139Thin bony cortex (HP:0002753)1.73812973
140Myokymia (HP:0002411)1.73305969
141Arnold-Chiari malformation (HP:0002308)1.73063827
142Delayed epiphyseal ossification (HP:0002663)1.72713016
143Gastrointestinal dysmotility (HP:0002579)1.71808282
144Distal sensory impairment (HP:0002936)1.71311117
145Delusions (HP:0000746)1.70485596
146Anteriorly placed anus (HP:0001545)1.70272388
147Spastic tetraparesis (HP:0001285)1.69827667
148Peripheral demyelination (HP:0011096)1.69792766
149Cholecystitis (HP:0001082)1.69709639
150Abnormal gallbladder physiology (HP:0012438)1.69709639
151Personality changes (HP:0000751)1.68607654
152Abnormalities of placenta or umbilical cord (HP:0001194)1.68554902
153Esophageal atresia (HP:0002032)1.68106843
154Upper motor neuron abnormality (HP:0002127)1.67766645
155Abnormal large intestine physiology (HP:0012700)1.67002776
156Clumsiness (HP:0002312)1.66869899
157Nail dystrophy (HP:0008404)1.66829589
158Clonus (HP:0002169)1.66796596
159Acanthocytosis (HP:0001927)1.66135751
160Epidermoid cyst (HP:0200040)1.65649942
161Vacuolated lymphocytes (HP:0001922)1.65408026
162Epiphyseal stippling (HP:0010655)1.65110024
163Hyperlipoproteinemia (HP:0010980)1.64593927
164Septate vagina (HP:0001153)1.64239321
165Delayed myelination (HP:0012448)1.63535265
166Patellar dislocation (HP:0002999)1.63348853
167Hyperglycinemia (HP:0002154)1.63308121
168Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62817781
169Flat cornea (HP:0007720)1.62809700
170Abnormality of carpal bone ossification (HP:0006257)1.62365975
171Dysostosis multiplex (HP:0000943)1.61189035
172Abnormality of the thoracic spine (HP:0100711)1.61013941
173Hypertriglyceridemia (HP:0002155)1.60917726
174Distal lower limb amyotrophy (HP:0008944)1.60326067
175Thin ribs (HP:0000883)1.57704816
176Capillary hemangiomas (HP:0005306)1.56338930
177Flat acetabular roof (HP:0003180)1.55042324
178Microvesicular hepatic steatosis (HP:0001414)1.54965178
179Poor suck (HP:0002033)1.54511385
180Proximal placement of thumb (HP:0009623)1.52976924
181Myopathic facies (HP:0002058)1.52960915
182Vaginal fistula (HP:0004320)1.52733788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.60706199
2EPHB14.17954403
3SIK14.13857810
4TRIB33.95606129
5OXSR13.43892986
6FGFR43.37585865
7BCR3.37411311
8PBK3.27340045
9LIMK13.21316817
10SMG12.87981048
11TESK22.86767084
12EEF2K2.75437215
13MARK12.59774561
14DYRK22.55109440
15MET2.49023052
16WNK42.44122230
17ICK2.30016318
18PKN12.26864501
19CSNK1G32.24388041
20ERN12.17821391
21IRAK32.15559426
22FGR1.96380959
23MST41.91558446
24CSNK1A1L1.83682196
25UHMK11.78384852
26MAP3K111.77128599
27RIPK11.74273164
28NTRK11.69147633
29CLK11.66013305
30CSNK1G21.57476835
31TYRO31.56758394
32CSNK1G11.54359651
33PKN21.50225397
34SIK21.46891571
35CDK121.42358720
36MAPKAPK51.41246909
37ROCK21.41054436
38BUB11.40720285
39TNIK1.38079713
40PNCK1.22085015
41PDGFRA1.21369179
42CDK141.19723930
43BRAF1.18296340
44TESK11.18055835
45FGFR21.14962255
46TAOK21.13380148
47PAK41.09841909
48CDK191.08567518
49MAP3K101.06883281
50PRKD31.03569427
51PTK61.02113300
52KDR1.01405961
53PAK61.00495870
54BMX0.99534811
55CDK150.98197350
56ERBB40.98097698
57BCKDK0.96481627
58WNK10.95737480
59CDK180.92921184
60ARAF0.91839733
61DYRK1B0.91069901
62CDK11A0.88710246
63CAMK1D0.88299221
64RPS6KA20.87342020
65MAP2K70.87262191
66KSR20.86576110
67MTOR0.84412149
68ABL20.83509426
69MAP3K10.83162286
70DDR20.82201560
71MAPK130.81348017
72SIK30.80690356
73LMTK20.80554429
74PAK10.80084846
75MAP2K20.77078980
76RAF10.73568310
77IRAK20.73562848
78BLK0.72907478
79CAMK2B0.72114936
80PAK30.71559233
81MAPKAPK30.69967845
82EPHA20.69741842
83PRKCQ0.68200944
84MAP3K60.67769386
85EPHB20.64883913
86PTK20.64056215
87MAP3K20.63663385
88LRRK20.62513140
89KSR10.61119704
90CDC42BPA0.60315530
91FGFR30.57934484
92MAPK110.57863854
93EPHA30.57826440
94GSK3A0.57355158
95AURKA0.55186727
96CAMK2D0.54224594
97AKT20.53870321
98CDK70.53723601
99MAP3K90.53281712
100CDK50.52906762
101PRPF4B0.50860311
102FYN0.50803826
103PRKCI0.50136630
104CSNK1D0.49826132
105IRAK10.49047385
106PRKG20.48308463
107DAPK30.47613690
108MAP3K80.47390455
109ILK0.46739938
110SGK2230.44657472
111SGK4940.44657472
112PHKG20.44037423
113PHKG10.44037423
114CAMK2G0.43354497
115TLK10.43026633
116PRKD20.42479143
117DAPK10.42245851
118RPS6KB20.42000077
119SCYL20.41865597
120TAOK10.41767337
121NME10.40975550
122PRKAA10.40389415
123MATK0.40372246
124NME20.40364591
125FGFR10.40229730
126NTRK20.40117047
127CSNK1E0.40077518
128TBK10.39598057
129RET0.38727722
130PRKD10.38497349
131CASK0.38277281
132MAP4K10.37355112
133RPS6KA10.37143412
134PDPK10.36448564
135MST1R0.36327092
136MAP2K10.35576479
137CDK40.35560513
138RPS6KL10.35524657
139RPS6KC10.35524657
140PAK20.35460858
141CSK0.35439264
142GRK60.35352010
143MARK20.35218302
144ALK0.34948922
145PRKCZ0.34740008
146MINK10.34558303
147ROCK10.33838672
148TSSK60.33242699
149PIM20.32809596
150RPS6KA40.32093926
151SRPK10.31237259
152CSNK1A10.30831074
153RPS6KA50.30413235
154SRC0.30237046
155CAMK2A0.29313839
156INSR0.29145193
157TTN0.28405693
158STK100.27271633
159EPHA40.26441510
160LATS20.26192976

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001007.41889995
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.91785303
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.66954548
4Fatty acid elongation_Homo sapiens_hsa000623.84952634
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.53689327
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.97363086
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.88797488
8Butanoate metabolism_Homo sapiens_hsa006502.72224393
9Other glycan degradation_Homo sapiens_hsa005112.20230291
10Fructose and mannose metabolism_Homo sapiens_hsa000512.01489211
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80634937
12Sulfur metabolism_Homo sapiens_hsa009201.79370853
13Ether lipid metabolism_Homo sapiens_hsa005651.78598975
14Fatty acid metabolism_Homo sapiens_hsa012121.75422899
15Oxidative phosphorylation_Homo sapiens_hsa001901.72690574
16Proteasome_Homo sapiens_hsa030501.72688212
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67509905
18Galactose metabolism_Homo sapiens_hsa000521.59891174
19Histidine metabolism_Homo sapiens_hsa003401.50233324
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.48787121
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45621605
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43431083
23Glutathione metabolism_Homo sapiens_hsa004801.29672258
24Parkinsons disease_Homo sapiens_hsa050121.28481448
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27058228
26Arginine and proline metabolism_Homo sapiens_hsa003301.19772637
27Axon guidance_Homo sapiens_hsa043601.16752358
28Peroxisome_Homo sapiens_hsa041461.14757228
29Pyruvate metabolism_Homo sapiens_hsa006201.08968854
30AMPK signaling pathway_Homo sapiens_hsa041521.08156955
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08135594
32Propanoate metabolism_Homo sapiens_hsa006401.07446716
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05849973
34Alzheimers disease_Homo sapiens_hsa050101.05340595
35Sphingolipid metabolism_Homo sapiens_hsa006000.99292488
36Glycosaminoglycan degradation_Homo sapiens_hsa005310.97609355
37Bladder cancer_Homo sapiens_hsa052190.94226141
38Nitrogen metabolism_Homo sapiens_hsa009100.92136918
39Fatty acid biosynthesis_Homo sapiens_hsa000610.91686336
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.89265105
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87369364
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86285702
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85904335
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85738377
45Protein export_Homo sapiens_hsa030600.85326393
46Synaptic vesicle cycle_Homo sapiens_hsa047210.83811663
47VEGF signaling pathway_Homo sapiens_hsa043700.83774946
48Vitamin B6 metabolism_Homo sapiens_hsa007500.83763092
49Insulin signaling pathway_Homo sapiens_hsa049100.83361293
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82872844
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82475314
52Acute myeloid leukemia_Homo sapiens_hsa052210.82185432
53Fatty acid degradation_Homo sapiens_hsa000710.81756047
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.80923511
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80875905
56N-Glycan biosynthesis_Homo sapiens_hsa005100.80466391
57Chemical carcinogenesis_Homo sapiens_hsa052040.78589181
58Linoleic acid metabolism_Homo sapiens_hsa005910.77652914
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.74648206
60Tryptophan metabolism_Homo sapiens_hsa003800.73930407
61Biosynthesis of amino acids_Homo sapiens_hsa012300.68152128
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67278257
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67246185
64Folate biosynthesis_Homo sapiens_hsa007900.66916816
65Tyrosine metabolism_Homo sapiens_hsa003500.66296533
66Huntingtons disease_Homo sapiens_hsa050160.65094888
67Phenylalanine metabolism_Homo sapiens_hsa003600.64794467
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63741194
69Renal cell carcinoma_Homo sapiens_hsa052110.63289040
70Chronic myeloid leukemia_Homo sapiens_hsa052200.62227900
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61537324
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60236853
73Fat digestion and absorption_Homo sapiens_hsa049750.59546241
74Retinol metabolism_Homo sapiens_hsa008300.58409119
75Sulfur relay system_Homo sapiens_hsa041220.58223299
76Tight junction_Homo sapiens_hsa045300.57878412
77Carbon metabolism_Homo sapiens_hsa012000.57709867
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.54713248
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53809195
80* Metabolic pathways_Homo sapiens_hsa011000.53190184
81Pentose phosphate pathway_Homo sapiens_hsa000300.52261644
82ErbB signaling pathway_Homo sapiens_hsa040120.51811542
83Phagosome_Homo sapiens_hsa041450.50421834
84Thyroid cancer_Homo sapiens_hsa052160.49566818
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48478511
86Vibrio cholerae infection_Homo sapiens_hsa051100.47644574
87Base excision repair_Homo sapiens_hsa034100.46849351
88Ribosome_Homo sapiens_hsa030100.46628597
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.44760940
90Arginine biosynthesis_Homo sapiens_hsa002200.44389936
91Collecting duct acid secretion_Homo sapiens_hsa049660.44083488
92RNA polymerase_Homo sapiens_hsa030200.43451996
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43112454
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.43071620
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42434343
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42423386
97PPAR signaling pathway_Homo sapiens_hsa033200.41847322
98Endometrial cancer_Homo sapiens_hsa052130.41103121
99mRNA surveillance pathway_Homo sapiens_hsa030150.41062496
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40275273
101beta-Alanine metabolism_Homo sapiens_hsa004100.40236146
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38650226
103Rheumatoid arthritis_Homo sapiens_hsa053230.38638476
104Notch signaling pathway_Homo sapiens_hsa043300.35332665
105B cell receptor signaling pathway_Homo sapiens_hsa046620.34885674
106HIF-1 signaling pathway_Homo sapiens_hsa040660.34200405
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33308790
108Spliceosome_Homo sapiens_hsa030400.31494758
109Prion diseases_Homo sapiens_hsa050200.30898367
110Hepatitis C_Homo sapiens_hsa051600.30427403
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29877246
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.29253189
113Shigellosis_Homo sapiens_hsa051310.28339152
114Bile secretion_Homo sapiens_hsa049760.27177187
115Endocytosis_Homo sapiens_hsa041440.26879973
116Lysine degradation_Homo sapiens_hsa003100.26597691
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25024609
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24876395
119Lysosome_Homo sapiens_hsa041420.24391346
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24264861
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24230693
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.24116972
123Malaria_Homo sapiens_hsa051440.22515494
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22493049
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.21979030
126Apoptosis_Homo sapiens_hsa042100.21052113
127Viral carcinogenesis_Homo sapiens_hsa052030.19849697
128Prolactin signaling pathway_Homo sapiens_hsa049170.19079565
129Non-small cell lung cancer_Homo sapiens_hsa052230.18929641
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18552084
131Vitamin digestion and absorption_Homo sapiens_hsa049770.17841199
132Serotonergic synapse_Homo sapiens_hsa047260.16624012
133Long-term depression_Homo sapiens_hsa047300.15728045
134Salmonella infection_Homo sapiens_hsa051320.15271422
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15147841
136Alcoholism_Homo sapiens_hsa050340.14536128
137Estrogen signaling pathway_Homo sapiens_hsa049150.13509540
138One carbon pool by folate_Homo sapiens_hsa006700.11851543
139Arachidonic acid metabolism_Homo sapiens_hsa005900.11695784
140Hedgehog signaling pathway_Homo sapiens_hsa043400.10667045
141Glycerolipid metabolism_Homo sapiens_hsa005610.09318555
142Hippo signaling pathway_Homo sapiens_hsa043900.07043628
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.06156824
144Graft-versus-host disease_Homo sapiens_hsa053320.06103877
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05417404
146Complement and coagulation cascades_Homo sapiens_hsa046100.05113608
147Mineral absorption_Homo sapiens_hsa049780.04953547

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