MX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.86647406
2regulation of RIG-I signaling pathway (GO:0039535)5.74582814
3positive regulation of natural killer cell differentiation (GO:0032825)5.68831768
4regulation of activation of Janus kinase activity (GO:0010533)5.64141884
5* cellular response to type I interferon (GO:0071357)5.62072182
6* type I interferon signaling pathway (GO:0060337)5.62072182
7* response to type I interferon (GO:0034340)5.55327736
8positive regulation of interferon-alpha production (GO:0032727)5.49709133
9response to interferon-alpha (GO:0035455)5.18877928
10regulation of interferon-alpha production (GO:0032647)5.15049974
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07132282
12T-helper 1 type immune response (GO:0042088)5.02349073
13positive regulation of type 2 immune response (GO:0002830)4.85830450
14regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.85083566
15NIK/NF-kappaB signaling (GO:0038061)4.63162002
16regulation of T-helper 1 cell differentiation (GO:0045625)4.60748775
17positive regulation of interleukin-12 production (GO:0032735)4.60142219
18neutrophil activation (GO:0042119)4.57820334
19granulocyte activation (GO:0036230)4.51178408
20antigen processing and presentation of endogenous antigen (GO:0019883)4.48380970
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44078670
22negative regulation of cell killing (GO:0031342)4.44078670
23regulation of dendritic cell antigen processing and presentation (GO:0002604)4.43734182
24* negative regulation of viral genome replication (GO:0045071)4.38185353
25regulation of MHC class I biosynthetic process (GO:0045343)4.34489285
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26715940
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26715940
28cellular response to interferon-beta (GO:0035458)4.22111748
29myeloid dendritic cell differentiation (GO:0043011)4.19429761
30natural killer cell mediated cytotoxicity (GO:0042267)4.17244422
31natural killer cell mediated immunity (GO:0002228)4.17244422
32negative regulation of interleukin-12 production (GO:0032695)4.14720720
33positive regulation of interleukin-17 production (GO:0032740)4.12862799
34cellular response to interferon-alpha (GO:0035457)4.12706352
35positive regulation of T cell cytokine production (GO:0002726)4.12426813
36regulation of interleukin-12 biosynthetic process (GO:0045075)4.11464711
37response to peptidoglycan (GO:0032494)4.11271207
38interferon-gamma-mediated signaling pathway (GO:0060333)4.03855106
39cellular response to exogenous dsRNA (GO:0071360)3.99655945
40positive regulation by symbiont of host defense response (GO:0052509)3.97042751
41modulation by symbiont of host defense response (GO:0052031)3.97042751
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97042751
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97042751
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.97042751
45modulation by symbiont of host immune response (GO:0052553)3.97042751
46cellular response to virus (GO:0098586)3.96061600
47positive regulation of antigen processing and presentation (GO:0002579)3.91037027
48positive regulation of response to biotic stimulus (GO:0002833)3.90826183
49positive regulation of interferon-beta production (GO:0032728)3.89691888
50regulation of immunoglobulin secretion (GO:0051023)3.88951351
51positive regulation of T-helper cell differentiation (GO:0045624)3.87507238
52defense response to protozoan (GO:0042832)3.87291568
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.85430450
54negative regulation of T cell mediated immunity (GO:0002710)3.84611867
55negative regulation of interleukin-17 production (GO:0032700)3.81866311
56myeloid dendritic cell activation (GO:0001773)3.80082954
57* regulation of viral genome replication (GO:0045069)3.76251330
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.72859504
59B cell mediated immunity (GO:0019724)3.68246342
60detection of other organism (GO:0098543)3.68152050
61detection of bacterium (GO:0016045)3.65806799
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.63868615
63natural killer cell activation involved in immune response (GO:0002323)3.63830700
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62857586
65response to interferon-beta (GO:0035456)3.60236019
66regulation of interleukin-17 production (GO:0032660)3.60105602
67regulation of natural killer cell differentiation (GO:0032823)3.59579532
68* negative regulation of viral process (GO:0048525)3.57255988
69regulation of T-helper 2 cell differentiation (GO:0045628)3.57175102
70regulation of B cell receptor signaling pathway (GO:0050855)3.56062755
71regulation of gamma-delta T cell activation (GO:0046643)3.55484575
72positive regulation of defense response to virus by host (GO:0002230)3.55210093
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.54577849
74lipopolysaccharide-mediated signaling pathway (GO:0031663)3.54522269
75monocyte chemotaxis (GO:0002548)3.52386344
76immunoglobulin mediated immune response (GO:0016064)3.50331727
77negative regulation of cytokine production involved in immune response (GO:0002719)3.49667672
78positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.49084134
79regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.49084134
80cellular response to zinc ion (GO:0071294)3.48236473
81regulation of interleukin-12 production (GO:0032655)3.47775646
82regulation of defense response to virus by host (GO:0050691)3.46339416
83regulation of type 2 immune response (GO:0002828)3.44113388
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.43532936
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43246059
86* defense response to virus (GO:0051607)3.40577339
87striated muscle atrophy (GO:0014891)3.39802351
88response to muramyl dipeptide (GO:0032495)3.39703244
89regulation of alpha-beta T cell proliferation (GO:0046640)3.36287875
90germinal center formation (GO:0002467)3.35906069
91regulation of hypersensitivity (GO:0002883)3.35631203
92response to exogenous dsRNA (GO:0043330)3.34820407
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34147902
94response to host immune response (GO:0052572)3.34147902
95regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.33576778
96regulation of antigen processing and presentation (GO:0002577)3.33090255
97positive regulation of monocyte chemotaxis (GO:0090026)3.32957452
98cellular response to interferon-gamma (GO:0071346)3.32951071
99response to host (GO:0075136)3.32436119
100response to host defenses (GO:0052200)3.32436119
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32436119
102dendritic cell differentiation (GO:0097028)3.31333490
103natural killer cell differentiation (GO:0001779)3.30398136
104regulation of memory T cell differentiation (GO:0043380)3.29653734
105positive regulation of natural killer cell activation (GO:0032816)3.29395947
106regulation of T-helper cell differentiation (GO:0045622)3.29237116
107regulation of type I interferon-mediated signaling pathway (GO:0060338)3.27578335
108lymphocyte chemotaxis (GO:0048247)3.27401372
109eosinophil chemotaxis (GO:0048245)3.26971084
110positive regulation of toll-like receptor signaling pathway (GO:0034123)3.25477163
111B cell proliferation (GO:0042100)3.22888743
112positive regulation of gamma-delta T cell activation (GO:0046645)3.21452342
113detection of external biotic stimulus (GO:0098581)3.20279903
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20005623
115macrophage activation involved in immune response (GO:0002281)3.18145391
116response to protozoan (GO:0001562)3.17552029
117regulation of interferon-beta production (GO:0032648)3.15280978
118detection of molecule of bacterial origin (GO:0032490)3.14290609
119positive regulation of humoral immune response (GO:0002922)3.12832984
120regulation of interferon-beta biosynthetic process (GO:0045357)3.12724621
121positive regulation of cellular amide metabolic process (GO:0034250)3.12550592
122natural killer cell activation (GO:0030101)3.12499358
123negative regulation of lymphocyte mediated immunity (GO:0002707)3.11882553
124B cell receptor signaling pathway (GO:0050853)3.11682345
125positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.11094477
126negative regulation of type I interferon production (GO:0032480)3.10683565
127leukocyte mediated cytotoxicity (GO:0001909)3.08649989
128negative regulation of innate immune response (GO:0045824)3.07902381
129CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.06747732
130regulation of mononuclear cell migration (GO:0071675)3.06489686
131T cell migration (GO:0072678)3.06254063
132myeloid cell activation involved in immune response (GO:0002275)3.05568397
133regulation of interferon-gamma biosynthetic process (GO:0045072)3.04731731
134negative regulation of type 2 immune response (GO:0002829)3.04418175
135regulation of T cell tolerance induction (GO:0002664)3.03682231
136response to interferon-gamma (GO:0034341)3.03604555
137regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96923201
138JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.95192532
139negative thymic T cell selection (GO:0045060)2.94638516
140interferon-gamma secretion (GO:0072643)2.91413356
141negative regulation of myeloid cell apoptotic process (GO:0033033)2.91163547
142regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87751564
143regulation of toll-like receptor signaling pathway (GO:0034121)2.87470330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.39571616
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.63465900
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.80506618
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.99566804
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.19579899
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.33821349
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.19728770
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32718728
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16766225
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.15927369
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02799774
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.02383528
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92540990
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.76391441
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54712492
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54480910
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29390322
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22934079
19MYC_22102868_ChIP-Seq_BL_Human2.09178800
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.98765673
21GATA1_22025678_ChIP-Seq_K562_Human1.95011065
22MYB_26560356_Chip-Seq_TH2_Human1.68202965
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.64578721
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.62153752
25UTX_26944678_Chip-Seq_JUKART_Human1.57144272
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56210951
27SPI1_23547873_ChIP-Seq_NB4_Human1.55269274
28VDR_24787735_ChIP-Seq_THP-1_Human1.53871468
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52774212
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50953355
31PU_27001747_Chip-Seq_BMDM_Mouse1.46500760
32MAF_26560356_Chip-Seq_TH1_Human1.43045833
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39203816
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38752496
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37736898
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37369124
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35750128
38MYB_26560356_Chip-Seq_TH1_Human1.35147136
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33277908
40GATA3_26560356_Chip-Seq_TH2_Human1.32174729
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31896867
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30716755
43TCF7_22412390_ChIP-Seq_EML_Mouse1.29455054
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26663653
45SPI1_23127762_ChIP-Seq_K562_Human1.25970971
46RUNX_20019798_ChIP-Seq_JUKART_Human1.24510222
47KDM2B_26808549_Chip-Seq_DND41_Human1.23699654
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18211353
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17803939
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13934774
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10076042
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09945583
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08646043
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08623979
55VDR_24763502_ChIP-Seq_THP-1_Human1.08065821
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.06530856
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05195184
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05038980
59EGR1_19032775_ChIP-ChIP_M12_Human1.03681059
60LXR_22292898_ChIP-Seq_THP-1_Human1.03619918
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.03429656
62GATA3_27048872_Chip-Seq_THYMUS_Human1.03170143
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02999523
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.02399121
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00851098
66RUNX1_22412390_ChIP-Seq_EML_Mouse0.99503283
67SCL_19346495_ChIP-Seq_HPC-7_Human0.97092096
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93638550
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93268142
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89568961
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87541505
72GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87446534
73GATA1_19941826_ChIP-Seq_K562_Human0.85218136
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84092406
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83558027
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82074899
77* SMRT_27268052_Chip-Seq_Bcells_Human0.81139321
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80130881
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78843752
80* SOX2_20726797_ChIP-Seq_SW620_Human0.78175088
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77829192
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77829192
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77787887
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77342827
85BCOR_27268052_Chip-Seq_Bcells_Human0.75671183
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74796343
87* BCL6_27268052_Chip-Seq_Bcells_Human0.74785489
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73986236
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72722057
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72491412
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72282725
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71102270
93STAT1_20625510_ChIP-Seq_HELA_Human0.70128468
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.69131371
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.68317785
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.68030854
97TRIM28_21343339_ChIP-Seq_HEK293_Human0.66873406
98CIITA_25753668_ChIP-Seq_RAJI_Human0.66478822
99CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66371403
100TFEB_21752829_ChIP-Seq_HELA_Human0.65976238
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64048654
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64004439
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.63889845
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62355531
105MAF_26560356_Chip-Seq_TH2_Human0.62300366
106KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61822276
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61802600
108PU1_27457419_Chip-Seq_LIVER_Mouse0.61684002
109CMYC_18555785_Chip-Seq_ESCs_Mouse0.61388149
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60193583
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.58674679
112VDR_21846776_ChIP-Seq_THP-1_Human0.57651693
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56748439
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.56479694
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.56127143
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.56127143
117NMYC_18555785_Chip-Seq_ESCs_Mouse0.54805433
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54176837
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.53766038
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.53325579
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.53037507
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52623631
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.52353212
124SMAD1_18555785_Chip-Seq_ESCs_Mouse0.51687939
125RUNX1_27457419_Chip-Seq_LIVER_Mouse0.51360637
126TP53_18474530_ChIP-ChIP_U2OS_Human0.51029498
127P53_22387025_ChIP-Seq_ESCs_Mouse0.49889252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.53828420
2* MP0009785_altered_susceptibility_to4.28187274
3MP0002148_abnormal_hypersensitivity_rea4.22482722
4MP0000685_abnormal_immune_system3.97516965
5MP0001790_abnormal_immune_system3.71578121
6MP0005387_immune_system_phenotype3.71578121
7MP0003436_decreased_susceptibility_to3.49383895
8MP0004510_myositis3.45453683
9MP0005000_abnormal_immune_tolerance3.17978815
10MP0005671_abnormal_response_to3.16235363
11* MP0005025_abnormal_response_to3.12264788
12MP0006082_CNS_inflammation2.87112876
13MP0002419_abnormal_innate_immunity2.86695680
14MP0003724_increased_susceptibility_to2.83409110
15MP0002452_abnormal_antigen_presenting2.72877482
16MP0002723_abnormal_immune_serum2.69899102
17MP0001800_abnormal_humoral_immune2.67293783
18MP0003300_gastrointestinal_ulcer2.42226579
19MP0002138_abnormal_hepatobiliary_system2.39194112
20MP0001819_abnormal_immune_cell2.35002970
21MP0003303_peritoneal_inflammation2.29839554
22MP0002420_abnormal_adaptive_immunity2.25162585
23MP0003191_abnormal_cellular_cholesterol2.25137495
24MP0009840_abnormal_foam_cell2.20144729
25MP0009764_decreased_sensitivity_to2.12028837
26MP0001348_abnormal_lacrimal_gland2.03881899
27MP0002163_abnormal_gland_morphology2.02741387
28MP0002277_abnormal_respiratory_mucosa2.02507432
29MP0001853_heart_inflammation2.02138883
30MP0005310_abnormal_salivary_gland2.00871536
31MP0002006_tumorigenesis1.99913129
32MP0002254_reproductive_system_inflammat1.97556272
33MP0004782_abnormal_surfactant_physiolog1.84990951
34MP0005058_abnormal_lysosome_morphology1.78197018
35MP0004947_skin_inflammation1.77145866
36MP0001533_abnormal_skeleton_physiology1.75464336
37MP0002405_respiratory_system_inflammati1.73514372
38* MP0000716_abnormal_immune_system1.71911159
39MP0001845_abnormal_inflammatory_respons1.69327178
40MP0005451_abnormal_body_composition1.67212029
41MP0002166_altered_tumor_susceptibility1.66995824
42MP0008469_abnormal_protein_level1.65425461
43MP0010155_abnormal_intestine_physiology1.64794825
44MP0002398_abnormal_bone_marrow1.61170929
45MP0003448_altered_tumor_morphology1.54504854
46MP0001346_abnormal_lacrimal_gland1.50955994
47MP0003172_abnormal_lysosome_physiology1.46192786
48MP0005464_abnormal_platelet_physiology1.40581535
49MP0000569_abnormal_digit_pigmentation1.29317522
50* MP0002429_abnormal_blood_cell1.28676399
51MP0002998_abnormal_bone_remodeling1.22536559
52MP0003183_abnormal_peptide_metabolism1.20637995
53MP0003075_altered_response_to1.19403811
54MP0003186_abnormal_redox_activity1.18774193
55MP0009333_abnormal_splenocyte_physiolog1.17584130
56MP0001545_abnormal_hematopoietic_system1.15677842
57MP0005397_hematopoietic_system_phenotyp1.15677842
58MP0000689_abnormal_spleen_morphology1.12641418
59MP0002722_abnormal_immune_system1.09920213
60MP0005379_endocrine/exocrine_gland_phen1.08213523
61MP0003763_abnormal_thymus_physiology1.08176218
62MP0010307_abnormal_tumor_latency1.07724745
63MP0000604_amyloidosis1.07366876
64MP0000858_altered_metastatic_potential1.05592286
65MP0003806_abnormal_nucleotide_metabolis0.99257916
66* MP0009763_increased_sensitivity_to0.98899991
67MP0002139_abnormal_hepatobiliary_system0.95154762
68MP0003091_abnormal_cell_migration0.93019422
69MP0010386_abnormal_urinary_bladder0.91062533
70MP0000343_altered_response_to0.90602457
71MP0009278_abnormal_bone_marrow0.89979762
72MP0001881_abnormal_mammary_gland0.88666615
73MP0004883_abnormal_blood_vessel0.85238988
74MP0000465_gastrointestinal_hemorrhage0.82558904
75MP0003646_muscle_fatigue0.82142594
76MP0008004_abnormal_stomach_pH0.79406532
77MP0008874_decreased_physiological_sensi0.79386990
78MP0005166_decreased_susceptibility_to0.78567077
79MP0003221_abnormal_cardiomyocyte_apopto0.76654084
80MP0005390_skeleton_phenotype0.76651314
81MP0005076_abnormal_cell_differentiation0.75074103
82MP0005164_abnormal_response_to0.69221872
83MP0001873_stomach_inflammation0.68865020
84MP0001663_abnormal_digestive_system0.68840888
85MP0003453_abnormal_keratinocyte_physiol0.65897619
86MP0004808_abnormal_hematopoietic_stem0.63849569
87MP0003656_abnormal_erythrocyte_physiolo0.63810567
88MP0000920_abnormal_myelination0.63544374
89MP0004381_abnormal_hair_follicle0.63426427
90MP0009765_abnormal_xenobiotic_induced0.63408664
91MP0008260_abnormal_autophagy0.62788183
92MP0001851_eye_inflammation0.62064317
93MP0000703_abnormal_thymus_morphology0.61977326
94MP0000627_abnormal_mammary_gland0.60014484
95MP0003566_abnormal_cell_adhesion0.58795927
96MP0008438_abnormal_cutaneous_collagen0.57958073
97MP0003690_abnormal_glial_cell0.57118202
98MP0002876_abnormal_thyroid_physiology0.56797629
99MP0002136_abnormal_kidney_physiology0.54250509
100MP0006054_spinal_hemorrhage0.53725522
101MP0002396_abnormal_hematopoietic_system0.53557547
102MP0003828_pulmonary_edema0.52250403
103MP0000371_diluted_coat_color0.52160966
104MP0005174_abnormal_tail_pigmentation0.51897536
105MP0005167_abnormal_blood-brain_barrier0.51762556
106MP0000609_abnormal_liver_physiology0.51602021
107MP0000249_abnormal_blood_vessel0.50866709
108MP0000490_abnormal_crypts_of0.50853998
109MP0002019_abnormal_tumor_incidence0.49439106
110MP0005023_abnormal_wound_healing0.47859281
111MP0002132_abnormal_respiratory_system0.47645230
112MP0002693_abnormal_pancreas_physiology0.46536245
113MP0003866_abnormal_defecation0.43683832
114MP0002933_joint_inflammation0.43209994
115MP0004858_abnormal_nervous_system0.43170898
116MP0003045_fibrosis0.43160034
117MP0000767_abnormal_smooth_muscle0.43034068
118MP0008057_abnormal_DNA_replication0.42015417
119MP0003795_abnormal_bone_structure0.40307586
120MP0001915_intracranial_hemorrhage0.37639289
121MP0009115_abnormal_fat_cell0.36190475
122MP0005535_abnormal_body_temperature0.35735625
123MP0002332_abnormal_exercise_endurance0.35596354

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.40996433
2Recurrent abscess formation (HP:0002722)6.04288742
3Recurrent bacterial skin infections (HP:0005406)5.93254345
4Eczematoid dermatitis (HP:0000976)5.78737176
5Autoimmune thrombocytopenia (HP:0001973)5.39278878
6Elevated erythrocyte sedimentation rate (HP:0003565)5.08942191
7Abnormality of macrophages (HP:0004311)5.03346507
8Recurrent gram-negative bacterial infections (HP:0005420)4.79566391
9Mediastinal lymphadenopathy (HP:0100721)4.67696682
10Retrobulbar optic neuritis (HP:0100654)4.65602892
11Optic neuritis (HP:0100653)4.65602892
12Gastrointestinal infarctions (HP:0005244)4.56287732
13Vasculitis (HP:0002633)4.52072967
14Orchitis (HP:0100796)4.42554953
15Basal ganglia calcification (HP:0002135)4.42228862
16Myositis (HP:0100614)4.32323391
17Hypergammaglobulinemia (HP:0010702)4.29945800
18Chronic otitis media (HP:0000389)4.18844449
19Recurrent viral infections (HP:0004429)4.01439476
20Recurrent fungal infections (HP:0002841)3.96024506
21Recurrent skin infections (HP:0001581)3.78882023
22Gastrointestinal stroma tumor (HP:0100723)3.68920078
23Porencephaly (HP:0002132)3.65639296
24Tetraparesis (HP:0002273)3.54386394
25Periodontitis (HP:0000704)3.52577256
26Gingivitis (HP:0000230)3.44522240
27Encephalitis (HP:0002383)3.33216910
28Vacuolated lymphocytes (HP:0001922)3.30013587
29Systemic lupus erythematosus (HP:0002725)3.22973271
30Pulmonary infiltrates (HP:0002113)3.16410386
31Colitis (HP:0002583)3.12025958
32Prostate neoplasm (HP:0100787)3.09773714
33Abnormality of liposaccharide metabolism (HP:0010968)3.09359010
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.09359010
35Abnormality of glycolipid metabolism (HP:0010969)3.09359010
36Arterial thrombosis (HP:0004420)3.03520790
37Autoimmune hemolytic anemia (HP:0001890)2.99505544
38Stomatitis (HP:0010280)2.98288241
39Premature loss of primary teeth (HP:0006323)2.97566926
40Chronic mucocutaneous candidiasis (HP:0002728)2.95918791
41Recurrent cutaneous fungal infections (HP:0011370)2.95918791
42Nasal polyposis (HP:0100582)2.93375800
43Lymphopenia (HP:0001888)2.88516264
44Gingival bleeding (HP:0000225)2.86089948
45Hemoptysis (HP:0002105)2.85952849
46Chronic obstructive pulmonary disease (HP:0006510)2.85583041
47Obstructive lung disease (HP:0006536)2.85583041
48Emphysema (HP:0002097)2.77151710
49Cleft eyelid (HP:0000625)2.76981248
50Abnormality of T cell number (HP:0011839)2.75014991
51Panhypogammaglobulinemia (HP:0003139)2.74163981
52Inflammation of the large intestine (HP:0002037)2.73888496
53Interstitial pulmonary disease (HP:0006530)2.69267056
54Keratoconjunctivitis sicca (HP:0001097)2.68360073
55Thick nail (HP:0001805)2.66433348
56Eosinophilia (HP:0001880)2.66129091
57Recurrent sinusitis (HP:0011108)2.65254584
58Recurrent pneumonia (HP:0006532)2.64729459
59Leukocytosis (HP:0001974)2.63162403
60Gastrointestinal inflammation (HP:0004386)2.62907946
61Joint swelling (HP:0001386)2.58388138
62IgM deficiency (HP:0002850)2.56914865
63Recurrent bronchitis (HP:0002837)2.56641826
64Meningitis (HP:0001287)2.51423109
65Abnormality of the nasal mucosa (HP:0000433)2.47345665
66IgA deficiency (HP:0002720)2.47196693
67Keratoconjunctivitis (HP:0001096)2.45929976
68Spontaneous hematomas (HP:0007420)2.45733546
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.45706241
70Vertebral compression fractures (HP:0002953)2.43013090
71Cellulitis (HP:0100658)2.42626634
72Amaurosis fugax (HP:0100576)2.42523373
73Abnormality of the endocardium (HP:0004306)2.41764633
74Restrictive lung disease (HP:0002091)2.39605131
75Plagiocephaly (HP:0001357)2.38898883
76Axonal loss (HP:0003447)2.38896444
77Urticaria (HP:0001025)2.38665362
78Pustule (HP:0200039)2.38147632
79Chronic sinusitis (HP:0011109)2.37903618
80Abnormality of the pericardium (HP:0001697)2.36977609
81Increased cerebral lipofuscin (HP:0011813)2.35360142
82Recurrent lower respiratory tract infections (HP:0002783)2.34794073
83Myocardial infarction (HP:0001658)2.33996698
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32636530
85Pulmonary embolism (HP:0002204)2.32560340
86Prolonged neonatal jaundice (HP:0006579)2.31610080
87Abnormality of B cell number (HP:0010975)2.31440172
88Cheilitis (HP:0100825)2.31046523
89IgG deficiency (HP:0004315)2.30848504
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.29137091
91Anorexia (HP:0002039)2.27676438
92Gangrene (HP:0100758)2.27546761
93Increased IgE level (HP:0003212)2.26933962
94Petechiae (HP:0000967)2.26081961
95Skin ulcer (HP:0200042)2.25627744
96Chest pain (HP:0100749)2.24589653
97Osteomyelitis (HP:0002754)2.23539083
98Bone pain (HP:0002653)2.23151094
99Peritonitis (HP:0002586)2.19900785
100Granulocytopenia (HP:0001913)2.19635912
101Osteolytic defects of the hand bones (HP:0009699)2.19215392
102Osteolytic defects of the phalanges of the hand (HP:0009771)2.19215392
103Skin rash (HP:0000988)2.16656980
104Sepsis (HP:0100806)2.16186569
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14376428
106Arthralgia (HP:0002829)2.13243288
107Thrombocytosis (HP:0001894)2.12169765
108Abnormality of eosinophils (HP:0001879)2.11469228
109Poor head control (HP:0002421)2.11053510
110Polyneuropathy (HP:0001271)2.11027312
111Abnormality of the peritoneum (HP:0002585)2.11019144
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09974435
113Dysostosis multiplex (HP:0000943)2.08484755
114Chronic diarrhea (HP:0002028)2.08251359
115Abnormality of the basal ganglia (HP:0002134)2.07155007
116B lymphocytopenia (HP:0010976)2.07121648
117Loss of speech (HP:0002371)2.06963593
118Abnormality of the prostate (HP:0008775)2.06032171
119Bronchitis (HP:0012387)2.05642188
120Progressive visual loss (HP:0000529)2.04162194
121Glomerulopathy (HP:0100820)2.04098747
122T lymphocytopenia (HP:0005403)2.01981019
123Abnormality of the pleura (HP:0002103)2.00916034
124Abnormality of T cells (HP:0002843)1.99416678
125Nephritis (HP:0000123)1.99149145
126Pathologic fracture (HP:0002756)1.97838340
127Purpura (HP:0000979)1.96351801
128Agammaglobulinemia (HP:0004432)1.95727714
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.94291062
130Abnormality of T cell physiology (HP:0011840)1.92261435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.14025770
2TYK24.66111945
3TBK13.86830646
4IKBKE3.58158590
5RIPK43.29899409
6JAK33.23464772
7IKBKB3.10550683
8JAK13.09181014
9IRAK43.03369360
10MAP3K132.95789241
11PIM22.78183083
12PBK2.70953742
13PRPF4B2.68197736
14CHUK2.28703748
15BLK2.18610908
16BMPR22.10377273
17IRAK31.93291201
18TXK1.90940593
19KIT1.90875415
20FGFR41.71750591
21MAP4K11.62230563
22ARAF1.47035506
23EIF2AK21.45108959
24SYK1.42059806
25MST41.33925125
26TAOK21.30828489
27TAOK31.26094610
28PIM11.25035343
29IRAK11.24866100
30NEK91.24811718
31MAP2K31.23359957
32EPHB11.22646892
33BMX1.22448659
34FGFR31.14405356
35CDC42BPA1.09639454
36CSK1.08151057
37STK41.07781415
38MAP3K31.06093270
39HCK1.05588101
40ITK1.05174400
41TNK21.04801315
42EPHA31.03304484
43BCR1.02290771
44DDR21.01024195
45RPS6KA40.99789905
46TAOK10.97609710
47JAK20.97043089
48ZAP700.93810452
49SIK30.88119924
50IRAK20.87769255
51TRIB30.82703346
52ABL20.81762455
53SMG10.81328256
54LCK0.80416657
55LYN0.80098251
56TRPM70.79952211
57MAPK110.79493160
58CDK120.79437452
59HIPK20.77907819
60MAP3K50.76021899
61PKN10.73013336
62PRKCQ0.72367647
63STK100.72141211
64BTK0.71536472
65STK240.71452361
66ERBB30.70158140
67CSF1R0.68523133
68ERN10.65223923
69MATK0.64210236
70MAPK70.63775094
71STK30.63129386
72FES0.58969391
73PRKCD0.58916554
74ADRBK20.58553029
75MARK30.57937384
76MST1R0.57797876
77TEC0.56540832
78ABL10.52104477
79PDK10.51890867
80TESK20.50868048
81YES10.46732025
82GRK60.46571244
83DAPK30.45839690
84SIK20.44900920
85RPS6KA50.44304812
86EGFR0.43788214
87PIK3CG0.43589118
88NME20.41867579
89CDK40.40476470
90MOS0.38867054
91FGR0.38533629
92RPS6KA10.36620296
93PRKCE0.36141832
94FYN0.35603060
95RIPK10.34571719
96NLK0.33237796
97SIK10.33234832
98TGFBR20.32866609
99RPS6KA60.32562984
100CAMKK20.32516230
101PDPK10.32440193
102PRKD20.32192214
103MAPKAPK20.31141880
104TESK10.30374388
105PLK40.30204629
106MAP3K120.28435267
107MARK20.27644048
108PTK60.26602672
109ZAK0.25763699
110MAPK40.25635625
111MAPK120.22958474
112LRRK20.22596973
113PRKCH0.21304450
114INSR0.21188261
115GRK70.20762253
116MELK0.20323591
117RPS6KB10.20093681
118MAP2K60.17545498
119MAPK30.17396620
120DAPK20.15980542
121CLK10.15873766
122PLK20.15750235
123MAP3K10.15536317
124KSR20.14673221
125MAP3K110.14478901
126TTN0.14165854
127RAF10.14036123
128IGF1R0.14031432
129EPHB20.13429489
130NUAK10.12076813
131AKT10.11697328
132SGK10.11184328
133CDK60.10771240

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.48492938
2Graft-versus-host disease_Homo sapiens_hsa053323.70737800
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.39810238
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.17769384
5Toll-like receptor signaling pathway_Homo sapiens_hsa046203.05631989
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.99967188
7Leishmaniasis_Homo sapiens_hsa051402.88019386
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.84562509
9Type I diabetes mellitus_Homo sapiens_hsa049402.65218293
10* Measles_Homo sapiens_hsa051622.55650079
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.55011073
12Autoimmune thyroid disease_Homo sapiens_hsa053202.48768988
13* Influenza A_Homo sapiens_hsa051642.34805357
14Pertussis_Homo sapiens_hsa051332.12518226
15Herpes simplex infection_Homo sapiens_hsa051682.11946739
16Legionellosis_Homo sapiens_hsa051342.09804930
17TNF signaling pathway_Homo sapiens_hsa046682.08243336
18Rheumatoid arthritis_Homo sapiens_hsa053232.07278804
19Asthma_Homo sapiens_hsa053102.00598531
20Osteoclast differentiation_Homo sapiens_hsa043801.92802764
21African trypanosomiasis_Homo sapiens_hsa051431.89490289
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88693697
23Staphylococcus aureus infection_Homo sapiens_hsa051501.75928759
24Malaria_Homo sapiens_hsa051441.75456293
25Toxoplasmosis_Homo sapiens_hsa051451.74882466
26Tuberculosis_Homo sapiens_hsa051521.72358238
27Viral myocarditis_Homo sapiens_hsa054161.60566922
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.60180794
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59758599
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50450557
31Primary immunodeficiency_Homo sapiens_hsa053401.44370121
32Apoptosis_Homo sapiens_hsa042101.43878998
33Chemokine signaling pathway_Homo sapiens_hsa040621.37293870
34Hepatitis C_Homo sapiens_hsa051601.34645714
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33648869
36Antigen processing and presentation_Homo sapiens_hsa046121.24990201
37Shigellosis_Homo sapiens_hsa051311.24182969
38Salmonella infection_Homo sapiens_hsa051321.23919553
39B cell receptor signaling pathway_Homo sapiens_hsa046621.16525671
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13881873
41Hepatitis B_Homo sapiens_hsa051611.09223525
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99885306
43Phagosome_Homo sapiens_hsa041450.99730554
44Hematopoietic cell lineage_Homo sapiens_hsa046400.91674962
45Prolactin signaling pathway_Homo sapiens_hsa049170.89109200
46Lysosome_Homo sapiens_hsa041420.84789977
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77164074
48T cell receptor signaling pathway_Homo sapiens_hsa046600.75378050
49Amoebiasis_Homo sapiens_hsa051460.68430696
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66685966
51Acute myeloid leukemia_Homo sapiens_hsa052210.65216449
52Caffeine metabolism_Homo sapiens_hsa002320.58493092
53Epstein-Barr virus infection_Homo sapiens_hsa051690.58306488
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.57875372
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57018805
56Prion diseases_Homo sapiens_hsa050200.55150527
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52809830
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51966533
59Type II diabetes mellitus_Homo sapiens_hsa049300.50272227
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47795523
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.46317619
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44706114
63Small cell lung cancer_Homo sapiens_hsa052220.42157973
64Other glycan degradation_Homo sapiens_hsa005110.41079420
65Collecting duct acid secretion_Homo sapiens_hsa049660.40021765
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39008037
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.37579469
68Chronic myeloid leukemia_Homo sapiens_hsa052200.37077016
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35959341
70Non-small cell lung cancer_Homo sapiens_hsa052230.35794473
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34594636
72Bladder cancer_Homo sapiens_hsa052190.33365874
73Viral carcinogenesis_Homo sapiens_hsa052030.32643092
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32633118
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.32159168
76Proteasome_Homo sapiens_hsa030500.31767238
77HIF-1 signaling pathway_Homo sapiens_hsa040660.30184003
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29874354
79Dorso-ventral axis formation_Homo sapiens_hsa043200.29198906
80p53 signaling pathway_Homo sapiens_hsa041150.28804954
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26014068
82Platelet activation_Homo sapiens_hsa046110.25716281
83HTLV-I infection_Homo sapiens_hsa051660.25184102
84Pancreatic cancer_Homo sapiens_hsa052120.24556309
85ABC transporters_Homo sapiens_hsa020100.23280368
86Endocytosis_Homo sapiens_hsa041440.22573960
87Renal cell carcinoma_Homo sapiens_hsa052110.21499740
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17350948
89One carbon pool by folate_Homo sapiens_hsa006700.14879592
90Prostate cancer_Homo sapiens_hsa052150.14825712
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.14681574
92Phenylalanine metabolism_Homo sapiens_hsa003600.14425359
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13977351
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.13814008
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13764948
96Insulin resistance_Homo sapiens_hsa049310.12798924
97Complement and coagulation cascades_Homo sapiens_hsa046100.12224608
98Sphingolipid metabolism_Homo sapiens_hsa006000.12094632
99MicroRNAs in cancer_Homo sapiens_hsa052060.10168763
100Proteoglycans in cancer_Homo sapiens_hsa052050.09782447
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09354800
102Notch signaling pathway_Homo sapiens_hsa043300.08865441
103MAPK signaling pathway_Homo sapiens_hsa040100.08702468
104Systemic lupus erythematosus_Homo sapiens_hsa053220.08673858
105GnRH signaling pathway_Homo sapiens_hsa049120.08509223
106Mineral absorption_Homo sapiens_hsa049780.07729830
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07562254
108mTOR signaling pathway_Homo sapiens_hsa041500.07251107
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06060808
110FoxO signaling pathway_Homo sapiens_hsa040680.05320422
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05135855
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.03540003
113Endometrial cancer_Homo sapiens_hsa052130.01872167
114VEGF signaling pathway_Homo sapiens_hsa043700.01709766

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