MXD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.31777937
2barbed-end actin filament capping (GO:0051016)3.21046350
3positive regulation of fatty acid beta-oxidation (GO:0032000)3.14794415
4alpha-linolenic acid metabolic process (GO:0036109)3.09935956
5valine metabolic process (GO:0006573)2.97354806
6regulation of ARF protein signal transduction (GO:0032012)2.93264574
7vascular endothelial growth factor signaling pathway (GO:0038084)2.90124089
8positive regulation of histone deacetylation (GO:0031065)2.83343930
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81710627
10negative regulation of cell killing (GO:0031342)2.81710627
11positive regulation of fatty acid oxidation (GO:0046321)2.81561357
12growth hormone receptor signaling pathway (GO:0060396)2.80251263
13response to laminar fluid shear stress (GO:0034616)2.79143396
14surfactant homeostasis (GO:0043129)2.78941955
15semaphorin-plexin signaling pathway (GO:0071526)2.76031858
16cytoskeletal anchoring at plasma membrane (GO:0007016)2.75683483
17regulation of fatty acid beta-oxidation (GO:0031998)2.71176874
18negative regulation of cell size (GO:0045792)2.70287886
19regulation of triglyceride catabolic process (GO:0010896)2.62752595
20protein carboxylation (GO:0018214)2.61876454
21peptidyl-glutamic acid carboxylation (GO:0017187)2.61876454
22adherens junction assembly (GO:0034333)2.61772758
23apoptotic cell clearance (GO:0043277)2.61212854
24protein targeting to plasma membrane (GO:0072661)2.60969258
25L-phenylalanine catabolic process (GO:0006559)2.60637925
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60637925
27regulation of early endosome to late endosome transport (GO:2000641)2.59983124
28vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.59424762
29regulation of ARF GTPase activity (GO:0032312)2.59241352
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.57920530
31positive regulation of receptor recycling (GO:0001921)2.56588559
32complement activation, alternative pathway (GO:0006957)2.55136650
33cell-cell junction maintenance (GO:0045217)2.53352684
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52315377
35mannose metabolic process (GO:0006013)2.52087737
36positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51433148
37cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50610021
38stress fiber assembly (GO:0043149)2.49711193
39modulation by symbiont of host cellular process (GO:0044068)2.48848926
40lymph vessel development (GO:0001945)2.47337558
41positive regulation of glycogen biosynthetic process (GO:0045725)2.46828750
42transcytosis (GO:0045056)2.46686567
43cellular response to growth hormone stimulus (GO:0071378)2.46585172
44regulation of extracellular matrix organization (GO:1903053)2.45123147
45cell-substrate adherens junction assembly (GO:0007045)2.44187636
46focal adhesion assembly (GO:0048041)2.44187636
47fatty acid beta-oxidation (GO:0006635)2.44038780
48protein heterotrimerization (GO:0070208)2.43179764
49fatty acid transmembrane transport (GO:1902001)2.42228226
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41634987
51modulation by virus of host process (GO:0019054)2.41297605
52activation of JUN kinase activity (GO:0007257)2.41075423
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40422810
54positive regulation of extracellular matrix organization (GO:1903055)2.39715788
55apoptotic process involved in morphogenesis (GO:0060561)2.37446177
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.37305417
57negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.37019524
58negative regulation of lipase activity (GO:0060192)2.36306668
59cell migration involved in heart development (GO:0060973)2.35724230
60L-phenylalanine metabolic process (GO:0006558)2.34438591
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34438591
62regulation of extracellular matrix disassembly (GO:0010715)2.33296315
63protein retention in ER lumen (GO:0006621)2.32476702
64virion attachment to host cell (GO:0019062)2.32390564
65adhesion of symbiont to host cell (GO:0044650)2.32390564
66regulation of fatty acid oxidation (GO:0046320)2.32044039
67maternal placenta development (GO:0001893)2.31642707
68fatty acid oxidation (GO:0019395)2.31141812
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.30767146
70hemidesmosome assembly (GO:0031581)2.30567614
71lipid oxidation (GO:0034440)2.28194185
72adhesion of symbiont to host (GO:0044406)2.27789914
73regulation of cholesterol homeostasis (GO:2000188)2.26738625
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26654755
75retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26396597
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.26328868
77regulation of T-helper 2 cell differentiation (GO:0045628)2.26114425
78sulfur amino acid catabolic process (GO:0000098)2.26049165
79positive regulation of protein dephosphorylation (GO:0035307)2.25742837
80positive regulation of Cdc42 GTPase activity (GO:0043089)2.25563240
81positive regulation of glycogen metabolic process (GO:0070875)2.24636901
82thymic T cell selection (GO:0045061)2.24625051
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24203075
84response to fluid shear stress (GO:0034405)2.23810839
85ethanol oxidation (GO:0006069)2.23582445
86regulation of sequestering of triglyceride (GO:0010889)2.23324421
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23272875
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.23263687
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.23263687
90fibril organization (GO:0097435)2.22025678
91regulation of gamma-delta T cell differentiation (GO:0045586)2.21723741
92regulation of lipid kinase activity (GO:0043550)2.19914591
93modulation by symbiont of host immune response (GO:0052553)2.18412544
94positive regulation by symbiont of host defense response (GO:0052509)2.18412544
95modulation by symbiont of host defense response (GO:0052031)2.18412544
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18412544
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18412544
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.18412544
99cortical actin cytoskeleton organization (GO:0030866)2.18371803
100positive regulation of lipid catabolic process (GO:0050996)2.18282899
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.18080261
102carnitine shuttle (GO:0006853)2.17931502
103glomerular basement membrane development (GO:0032836)2.17775181
104regulation of cholesterol storage (GO:0010885)2.16618193
105regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.16250603
106activation of MAPKKK activity (GO:0000185)2.15765991
107cell-substrate junction assembly (GO:0007044)2.15597748
108positive regulation of Rap GTPase activity (GO:0032854)2.15514940
109negative regulation of granulocyte differentiation (GO:0030853)2.15319024
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14928488
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.14235936
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.13944837
113regulation of glucose import in response to insulin stimulus (GO:2001273)2.13613797
114fatty acid catabolic process (GO:0009062)2.13581649
115short-chain fatty acid metabolic process (GO:0046459)2.13576149
116negative regulation of fibrinolysis (GO:0051918)2.13386786
117gland morphogenesis (GO:0022612)2.12800299
118positive regulation of triglyceride biosynthetic process (GO:0010867)2.12617414
119extracellular fibril organization (GO:0043206)2.12047391
120regulation of triglyceride metabolic process (GO:0090207)2.11888296
121peptidyl-tyrosine autophosphorylation (GO:0038083)2.11846181
122regulation of leukocyte degranulation (GO:0043300)2.11013372
123negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.10744425
124regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.09329066
125regulation of response to osmotic stress (GO:0047484)2.09269374
126regulation of endothelial cell chemotaxis (GO:2001026)2.09243479
127positive regulation of fatty acid metabolic process (GO:0045923)2.09041068
128cerebellar granule cell differentiation (GO:0021707)2.08829034
129positive regulation of cholesterol efflux (GO:0010875)2.08741442
130positive regulation of triglyceride metabolic process (GO:0090208)2.08455362
131regulation of triglyceride biosynthetic process (GO:0010866)2.08453896
132positive regulation of cholesterol transport (GO:0032376)2.08446970
133positive regulation of sterol transport (GO:0032373)2.08446970
134chemical homeostasis within a tissue (GO:0048875)2.06632195
135endothelial cell chemotaxis (GO:0035767)2.06590342
136response to muramyl dipeptide (GO:0032495)2.06025979
137signal complex assembly (GO:0007172)2.05912802
138cell volume homeostasis (GO:0006884)2.05512078
139monocarboxylic acid catabolic process (GO:0072329)2.05038447
140regulation of macrophage cytokine production (GO:0010935)2.04778324
141regulation of fibrinolysis (GO:0051917)2.04571801
142regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.04507273
143low-density lipoprotein particle clearance (GO:0034383)2.04295314
144Rho protein signal transduction (GO:0007266)2.03900811
145modulation by virus of host morphology or physiology (GO:0019048)2.03679079
146negative regulation of fatty acid transport (GO:2000192)2.03590511
147regulation of protein activation cascade (GO:2000257)2.03525450
148negative regulation of protein autophosphorylation (GO:0031953)2.03355694
149basement membrane organization (GO:0071711)2.03160795
150negative regulation of myotube differentiation (GO:0010832)2.02726695
151triglyceride catabolic process (GO:0019433)2.02715844
152regulation of p38MAPK cascade (GO:1900744)2.02655340
153negative regulation of glial cell proliferation (GO:0060253)2.02494442
154hormone catabolic process (GO:0042447)2.02400785
155regulation of complement activation (GO:0030449)2.01951523
156acylglycerol catabolic process (GO:0046464)2.01914337
157neutral lipid catabolic process (GO:0046461)2.01914337
158venous blood vessel morphogenesis (GO:0048845)2.01592760
159lysine metabolic process (GO:0006553)2.01465564
160lysine catabolic process (GO:0006554)2.01465564
161atrioventricular valve morphogenesis (GO:0003181)2.00941184
162antigen processing and presentation of endogenous antigen (GO:0019883)2.00392068
163intracellular lipid transport (GO:0032365)2.00287389
164embryo implantation (GO:0007566)1.99927572
165retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.99880019
166positive regulation of lipid kinase activity (GO:0090218)1.99769310
167phospholipid homeostasis (GO:0055091)1.99256863
168G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.99120055
169positive thymic T cell selection (GO:0045059)1.99107596
1702-oxoglutarate metabolic process (GO:0006103)1.98773485
171protein localization to endosome (GO:0036010)1.98567619
172phospholipid efflux (GO:0033700)1.98039110
173collagen fibril organization (GO:0030199)1.97089589
174desmosome organization (GO:0002934)1.96070345
175glomerular visceral epithelial cell development (GO:0072015)1.94811736
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.94674779
177epoxygenase P450 pathway (GO:0019373)1.94549363
178regulation of cholesterol biosynthetic process (GO:0045540)1.93982351
179coronary vasculature morphogenesis (GO:0060977)1.93891818
180skin morphogenesis (GO:0043589)1.93817662
181activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.93792607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.40462604
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.24004451
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.68025279
4VDR_21846776_ChIP-Seq_THP-1_Human2.59934639
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.53320398
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38257934
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33249440
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.22166176
9* TRIM28_21343339_ChIP-Seq_HEK293_Human2.21226124
10CLOCK_20551151_ChIP-Seq_293T_Human2.14953317
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12558320
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11975934
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03097806
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01647417
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91976964
16GATA1_22025678_ChIP-Seq_K562_Human1.90700660
17MYC_22102868_ChIP-Seq_BL_Human1.87998462
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80508227
19ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77114589
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76475027
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.76387175
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76080877
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75633129
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.73036417
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72777076
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.71244844
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.66923271
28VDR_24763502_ChIP-Seq_THP-1_Human1.66161490
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.63577142
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.61061271
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58856885
32P68_20966046_ChIP-Seq_HELA_Human1.56858023
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54402411
34* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53632637
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.52881746
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52437511
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50940415
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50536053
39SMC4_20622854_ChIP-Seq_HELA_Human1.49685736
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45579108
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45552963
42* TBX20_22328084_ChIP-Seq_HEART_Mouse1.43275446
43* TBX20_22080862_ChIP-Seq_HEART_Mouse1.43275446
44* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42327361
45CREB1_26743006_Chip-Seq_LNCaP_Human1.41697318
46RUNX_20019798_ChIP-Seq_JUKART_Human1.41110929
47* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40984525
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39436530
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.38721471
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.36139300
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35843401
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35065586
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33415952
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32716621
55* CTCF_27219007_Chip-Seq_Bcells_Human1.31548455
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.30522134
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28717025
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27891674
59MAF_26560356_Chip-Seq_TH1_Human1.26989347
60LXR_22292898_ChIP-Seq_THP-1_Human1.26134140
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.24889706
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23656607
63KDM2B_26808549_Chip-Seq_DND41_Human1.22582859
64UTX_26944678_Chip-Seq_JUKART_Human1.22316821
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22180145
66DROSHA_22980978_ChIP-Seq_HELA_Human1.22130344
67KDM2B_26808549_Chip-Seq_K562_Human1.20975944
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20945416
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20890185
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20848969
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20350695
72MAF_26560356_Chip-Seq_TH2_Human1.19803323
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.19377997
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18872891
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18017101
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.17905583
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17799809
78SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15652682
79* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15311799
80GATA1_19941826_ChIP-Seq_K562_Human1.15245284
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14672811
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14669207
83* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13943150
84TCF7_22412390_ChIP-Seq_EML_Mouse1.13715004
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13481620
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.12797590
87* BCOR_27268052_Chip-Seq_Bcells_Human1.12601245
88EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11069023
89RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11069023
90AHR_22903824_ChIP-Seq_MCF-7_Human1.11044733
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10835254
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09687781
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08360878
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07684225
95* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07684087
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07679000
97* BCL6_27268052_Chip-Seq_Bcells_Human1.07518597
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06837538
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06565838
100CJUN_26792858_Chip-Seq_BT549_Human1.06404157
101TP63_22573176_ChIP-Seq_HFKS_Human1.06268518
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05053507
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03875480
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.03806646
105TP53_22127205_ChIP-Seq_IMR90_Human1.03585236
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03233581
107RACK7_27058665_Chip-Seq_MCF-7_Human1.02549819
108SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02441088
109SCL_19346495_ChIP-Seq_HPC-7_Human1.02133258
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01850537
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.01786247
112* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01648056
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00498825
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99915068
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99422387
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.99380847
117* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98733474
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98344884
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98282278
120GATA2_19941826_ChIP-Seq_K562_Human0.97621641
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97393521
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97393521
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.97340521
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97244520
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.97120827
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96609514
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96439214
128SPI1_23127762_ChIP-Seq_K562_Human0.95978023
129EGR1_19374776_ChIP-ChIP_THP-1_Human0.95585367
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.95400554
131* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95332250
132EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95300066
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94384837
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93863052
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93376076
136IRF8_22096565_ChIP-ChIP_GC-B_Human0.92151766
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91874218
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90590010
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89993744
140* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89905428
141SOX2_20726797_ChIP-Seq_SW620_Human0.89765519
142VDR_24787735_ChIP-Seq_THP-1_Human0.89688018
143EED_16625203_ChIP-ChIP_MESCs_Mouse0.89276480
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88518280
145* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88159246
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87724265
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87461956
148P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87227526
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85583413
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.85041853
151* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84355787
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83522798
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83167216
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.82711767
155CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82300889
156SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82261215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.61638674
2MP0002139_abnormal_hepatobiliary_system2.91042244
3MP0005275_abnormal_skin_tensile2.62128973
4MP0005365_abnormal_bile_salt2.56471691
5MP0004858_abnormal_nervous_system2.55274099
6MP0010368_abnormal_lymphatic_system2.44138049
7MP0003191_abnormal_cellular_cholesterol2.38257891
8MP0003300_gastrointestinal_ulcer2.37203493
9MP0003705_abnormal_hypodermis_morpholog2.34409037
10MP0005409_darkened_coat_color2.25376846
11MP0003303_peritoneal_inflammation2.23791279
12MP0001879_abnormal_lymphatic_vessel2.17509529
13MP0004272_abnormal_basement_membrane2.15818605
14MP0003436_decreased_susceptibility_to2.14427796
15MP0005670_abnormal_white_adipose2.11578801
16MP0004130_abnormal_muscle_cell2.10064963
17MP0009384_cardiac_valve_regurgitation2.09988706
18MP0003252_abnormal_bile_duct2.09694879
19MP0003172_abnormal_lysosome_physiology2.09217652
20MP0005360_urolithiasis2.04977942
21MP0003045_fibrosis2.01444613
22MP0005451_abnormal_body_composition1.99073568
23MP0008260_abnormal_autophagy1.98559570
24MP0009780_abnormal_chondrocyte_physiolo1.97214917
25MP0010329_abnormal_lipoprotein_level1.92554419
26MP0002166_altered_tumor_susceptibility1.87768721
27MP0004185_abnormal_adipocyte_glucose1.84409764
28MP0003329_amyloid_beta_deposits1.83589881
29MP0001958_emphysema1.78166135
30MP0005058_abnormal_lysosome_morphology1.76679020
31MP0002254_reproductive_system_inflammat1.75514853
32MP0005666_abnormal_adipose_tissue1.72924649
33MP0001348_abnormal_lacrimal_gland1.72887231
34MP0002249_abnormal_larynx_morphology1.72323401
35MP0010234_abnormal_vibrissa_follicle1.67952407
36MP0002877_abnormal_melanocyte_morpholog1.67229871
37MP0000013_abnormal_adipose_tissue1.66150559
38MP0009278_abnormal_bone_marrow1.66117462
39MP0003724_increased_susceptibility_to1.65417208
40MP0002060_abnormal_skin_morphology1.63892909
41MP0003091_abnormal_cell_migration1.61067897
42MP0003279_aneurysm1.60233005
43MP0002837_dystrophic_cardiac_calcinosis1.55305420
44MP0004859_abnormal_synaptic_plasticity1.54408257
45MP0005375_adipose_tissue_phenotype1.53711832
46MP0005503_abnormal_tendon_morphology1.52398070
47MP0005085_abnormal_gallbladder_physiolo1.46973672
48MP0004510_myositis1.44641898
49MP0005076_abnormal_cell_differentiation1.43203927
50MP0008961_abnormal_basal_metabolism1.38973494
51MP0001666_abnormal_nutrient_absorption1.37657605
52MP0000003_abnormal_adipose_tissue1.34916420
53MP0003879_abnormal_hair_cell1.34387730
54MP0004084_abnormal_cardiac_muscle1.34354776
55MP0002118_abnormal_lipid_homeostasis1.34250228
56MP0006082_CNS_inflammation1.32646650
57MP0008875_abnormal_xenobiotic_pharmacok1.32139551
58MP0003183_abnormal_peptide_metabolism1.30617014
59MP0000604_amyloidosis1.28496029
60MP0006054_spinal_hemorrhage1.21433060
61MP0009643_abnormal_urine_homeostasis1.19942784
62MP0002909_abnormal_adrenal_gland1.19827507
63MP0002896_abnormal_bone_mineralization1.19371692
64MP0002168_other_aberrant_phenotype1.17514171
65MP0003690_abnormal_glial_cell1.16843276
66MP0004036_abnormal_muscle_relaxation1.16648806
67MP0000678_abnormal_parathyroid_gland1.16390306
68MP0000681_abnormal_thyroid_gland1.14629779
69MP0000733_abnormal_muscle_development1.13988709
70MP0005390_skeleton_phenotype1.13264813
71MP0000858_altered_metastatic_potential1.11432882
72MP0005257_abnormal_intraocular_pressure1.10692414
73MP0000609_abnormal_liver_physiology1.10002661
74MP0002009_preneoplasia1.09962813
75MP0003566_abnormal_cell_adhesion1.09757051
76MP0000767_abnormal_smooth_muscle1.08199673
77MP0009840_abnormal_foam_cell1.07583250
78MP0002295_abnormal_pulmonary_circulatio1.05960438
79MP0002796_impaired_skin_barrier1.04734390
80MP0001756_abnormal_urination1.04227320
81MP0002998_abnormal_bone_remodeling1.04083023
82MP0002138_abnormal_hepatobiliary_system1.00697549
83MP0001873_stomach_inflammation1.00212555
84MP0002419_abnormal_innate_immunity0.99330421
85MP0005623_abnormal_meninges_morphology0.98611172
86MP0001270_distended_abdomen0.98409454
87MP0003634_abnormal_glial_cell0.97794828
88MP0001849_ear_inflammation0.97468406
89MP0005332_abnormal_amino_acid0.97314394
90MP0005025_abnormal_response_to0.97078002
91MP0002971_abnormal_brown_adipose0.96365320
92MP0002089_abnormal_postnatal_growth/wei0.96304201
93MP0002006_tumorigenesis0.95639649
94MP0005595_abnormal_vascular_smooth0.92717809
95MP0005220_abnormal_exocrine_pancreas0.92673852
96MP0000465_gastrointestinal_hemorrhage0.92337773
97MP0005166_decreased_susceptibility_to0.91490477
98MP0001533_abnormal_skeleton_physiology0.89550150
99MP0006138_congestive_heart_failure0.89473478
100MP0005167_abnormal_blood-brain_barrier0.89380834
101MP0010155_abnormal_intestine_physiology0.88516558
102MP0000751_myopathy0.87607688
103MP0001851_eye_inflammation0.86918843
104MP0003195_calcinosis0.86079602
105MP0009379_abnormal_foot_pigmentation0.83443143
106MP0001765_abnormal_ion_homeostasis0.83309533
107MP0000759_abnormal_skeletal_muscle0.83078499
108MP0005334_abnormal_fat_pad0.82504862
109MP0003075_altered_response_to0.82246150
110MP0000230_abnormal_systemic_arterial0.81651901
111MP0010030_abnormal_orbit_morphology0.80353492
112MP0000920_abnormal_myelination0.80335898
113MP0002933_joint_inflammation0.80335683
114MP0001944_abnormal_pancreas_morphology0.80103021
115MP0009333_abnormal_splenocyte_physiolog0.79640559
116MP0009115_abnormal_fat_cell0.79552709
117MP0003763_abnormal_thymus_physiology0.78356425
118MP0000249_abnormal_blood_vessel0.77930150
119MP0002932_abnormal_joint_morphology0.77186341
120MP0002108_abnormal_muscle_morphology0.76825780
121MP0008569_lethality_at_weaning0.76766796
122MP0008874_decreased_physiological_sensi0.76138120
123MP0004381_abnormal_hair_follicle0.75994962
124MP0005319_abnormal_enzyme/_coenzyme0.74736733
125MP0002128_abnormal_blood_circulation0.74066672
126MP0002136_abnormal_kidney_physiology0.73810763
127MP0001542_abnormal_bone_strength0.73803290
128MP0002078_abnormal_glucose_homeostasis0.73242608
129MP0010630_abnormal_cardiac_muscle0.72811377
130MP0005023_abnormal_wound_healing0.71927679
131MP0005083_abnormal_biliary_tract0.71836157
132MP0005000_abnormal_immune_tolerance0.71677958
133MP0004145_abnormal_muscle_electrophysio0.71171627
134MP0003795_abnormal_bone_structure0.70495973
135MP0005385_cardiovascular_system_phenoty0.70418682
136MP0001544_abnormal_cardiovascular_syste0.70418682
137MP0001545_abnormal_hematopoietic_system0.70228311
138MP0005397_hematopoietic_system_phenotyp0.70228311
139MP0003866_abnormal_defecation0.70078004
140MP0001790_abnormal_immune_system0.69583346
141MP0005387_immune_system_phenotype0.69583346
142MP0005464_abnormal_platelet_physiology0.69378411
143MP0005584_abnormal_enzyme/coenzyme_acti0.68896467
144MP0000343_altered_response_to0.67915103
145MP0003828_pulmonary_edema0.66821697
146MP0010678_abnormal_skin_adnexa0.66632387
147MP0004087_abnormal_muscle_fiber0.66508026
148MP0000534_abnormal_ureter_morphology0.66481282
149MP0005165_increased_susceptibility_to0.65194992
150MP0005508_abnormal_skeleton_morphology0.64944013
151MP0001661_extended_life_span0.64878854
152MP0004947_skin_inflammation0.63976393
153MP0003453_abnormal_keratinocyte_physiol0.63886484
154MP0000685_abnormal_immune_system0.63529030

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.04923703
2Broad metatarsal (HP:0001783)3.52012305
3Deep venous thrombosis (HP:0002625)3.40051648
4Protrusio acetabuli (HP:0003179)3.31503837
5Cerebral aneurysm (HP:0004944)3.19117773
6Aortic dissection (HP:0002647)3.18938982
7Complement deficiency (HP:0004431)3.11624893
8Aortic aneurysm (HP:0004942)3.09804331
9Premature rupture of membranes (HP:0001788)2.94270899
10Vertebral compression fractures (HP:0002953)2.72863354
11Dysostosis multiplex (HP:0000943)2.66287469
12Right ventricular cardiomyopathy (HP:0011663)2.61286393
13Hematochezia (HP:0002573)2.59974126
14Atrophic scars (HP:0001075)2.54648652
15Xanthomatosis (HP:0000991)2.52706829
16Cervical subluxation (HP:0003308)2.49648575
17Eczematoid dermatitis (HP:0000976)2.46923424
18Mitral valve prolapse (HP:0001634)2.46521250
19Broad face (HP:0000283)2.46442324
20Hyperacusis (HP:0010780)2.45773524
21Urinary glycosaminoglycan excretion (HP:0003541)2.44570015
22Mucopolysacchariduria (HP:0008155)2.44570015
23Aneurysm (HP:0002617)2.40468111
24Shallow orbits (HP:0000586)2.39039837
25Abnormality of complement system (HP:0005339)2.38928233
26Ankle contracture (HP:0006466)2.38723935
27Increased variability in muscle fiber diameter (HP:0003557)2.38527190
28Neurofibrillary tangles (HP:0002185)2.38408603
29Hypoglycemic coma (HP:0001325)2.36941210
30Ketoacidosis (HP:0001993)2.32477747
31Arterial tortuosity (HP:0005116)2.30664790
32Abnormality of the common coagulation pathway (HP:0010990)2.29710776
33Hemorrhage of the eye (HP:0011885)2.29468310
34Polycythemia (HP:0001901)2.28352597
35Hyperlipoproteinemia (HP:0010980)2.26198281
36Vascular tortuosity (HP:0004948)2.26156711
37Buphthalmos (HP:0000557)2.26149561
38Genu recurvatum (HP:0002816)2.25554844
39Ketosis (HP:0001946)2.25016421
40Myocardial infarction (HP:0001658)2.21438468
41Stridor (HP:0010307)2.20119048
42Abnormality of polysaccharide metabolism (HP:0011012)2.19716089
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19716089
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19716089
45Spondylolisthesis (HP:0003302)2.16987569
46Mitral stenosis (HP:0001718)2.16935428
47Hyporeflexia of lower limbs (HP:0002600)2.15031656
48Joint stiffness (HP:0001387)2.14525068
49Emphysema (HP:0002097)2.14401055
50Abnormality of the intrinsic pathway (HP:0010989)2.13655527
51Supranuclear gaze palsy (HP:0000605)2.12597585
52Hypercortisolism (HP:0001578)2.10760965
53Increased connective tissue (HP:0009025)2.10594071
54Biconcave vertebral bodies (HP:0004586)2.10178527
55J-shaped sella turcica (HP:0002680)2.09906784
56Prolonged partial thromboplastin time (HP:0003645)2.09620562
57Peritonitis (HP:0002586)2.09339906
58Spontaneous hematomas (HP:0007420)2.08404379
59Nephritis (HP:0000123)2.08283701
60Thin bony cortex (HP:0002753)2.07678191
61Cellulitis (HP:0100658)2.07566424
62Distal lower limb muscle weakness (HP:0009053)2.07041895
63Cerebral inclusion bodies (HP:0100314)2.05231222
64Type 1 muscle fiber predominance (HP:0003803)2.05054515
65Abnormality of skeletal muscle fiber size (HP:0012084)2.03470422
66Lymphangioma (HP:0100764)1.99802288
67Long toe (HP:0010511)1.99709965
68Mesangial abnormality (HP:0001966)1.99078380
69Systemic lupus erythematosus (HP:0002725)1.99045906
70Acanthosis nigricans (HP:0000956)1.95986310
71Asymmetric septal hypertrophy (HP:0001670)1.95958719
72Joint hemorrhage (HP:0005261)1.95345306
73Wormian bones (HP:0002645)1.94262325
74Atelectasis (HP:0100750)1.93060951
75Polygenic inheritance (HP:0010982)1.92935025
76Striae distensae (HP:0001065)1.91666239
77Annular pancreas (HP:0001734)1.91479442
78Ulnar bowing (HP:0003031)1.91010017
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90880284
80Disproportionate tall stature (HP:0001519)1.89789273
81Visceral angiomatosis (HP:0100761)1.89733722
82Joint laxity (HP:0001388)1.88853465
83Amyloidosis (HP:0011034)1.88556222
84Distal lower limb amyotrophy (HP:0008944)1.87709283
85Bundle branch block (HP:0011710)1.87168810
86Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86903645
87Spinal rigidity (HP:0003306)1.86513057
88Hypoplasia of the iris (HP:0007676)1.85836039
89Upper limb amyotrophy (HP:0009129)1.85745581
90Distal upper limb amyotrophy (HP:0007149)1.85745581
91Bladder diverticulum (HP:0000015)1.85728063
92Glomerulonephritis (HP:0000099)1.85480725
93Follicular hyperkeratosis (HP:0007502)1.84856339
94Abnormality of glycolipid metabolism (HP:0010969)1.84544351
95Abnormality of liposaccharide metabolism (HP:0010968)1.84544351
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.84544351
97Achilles tendon contracture (HP:0001771)1.83492051
98Turricephaly (HP:0000262)1.83475632
99Axonal loss (HP:0003447)1.83198562
100Hyperextensible skin (HP:0000974)1.82674447
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.81882755
102Fragile skin (HP:0001030)1.81811141
103Gingivitis (HP:0000230)1.81083265
104Dilatation of the ascending aorta (HP:0005111)1.80764323
105Mildly elevated creatine phosphokinase (HP:0008180)1.79815934
106Increased cerebral lipofuscin (HP:0011813)1.79698221
107Vacuolated lymphocytes (HP:0001922)1.78513810
108Ectopia lentis (HP:0001083)1.78463596
109Spinal canal stenosis (HP:0003416)1.78251551
110Slender build (HP:0001533)1.77347753
111Abnormality of the nasal mucosa (HP:0000433)1.77204889
112Back pain (HP:0003418)1.77134250
113Mitral regurgitation (HP:0001653)1.77034468
114Focal segmental glomerulosclerosis (HP:0000097)1.76748070
115Abnormality of fatty-acid metabolism (HP:0004359)1.76183199
116Hyperparathyroidism (HP:0000843)1.75763496
117Nuclear cataract (HP:0100018)1.75244773
118Flat acetabular roof (HP:0003180)1.75182279
119Intrahepatic cholestasis (HP:0001406)1.75136059
120Increased IgE level (HP:0003212)1.74332944
121Nasal polyposis (HP:0100582)1.72116463
122Growth hormone excess (HP:0000845)1.70693909
123Camptodactyly of toe (HP:0001836)1.70493397
124Spinal cord lesions (HP:0100561)1.69939311
125Syringomyelia (HP:0003396)1.69939311
126Hypoalphalipoproteinemia (HP:0003233)1.69736832
127Hemangiomatosis (HP:0007461)1.69635738
128Interstitial pulmonary disease (HP:0006530)1.69144950
129Hypokalemic alkalosis (HP:0001949)1.68994686
130Colitis (HP:0002583)1.68137694
131Aortic regurgitation (HP:0001659)1.67839249
132Venous abnormality (HP:0002624)1.67270994
133Abnormality of the thoracic spine (HP:0100711)1.67196602
134Increased CSF protein (HP:0002922)1.67022159
135Protuberant abdomen (HP:0001538)1.66975128
136Blue sclerae (HP:0000592)1.66538784
137Bronchomalacia (HP:0002780)1.66273294
138Bone cyst (HP:0012062)1.65934706
139Segmental peripheral demyelination/remyelination (HP:0003481)1.65420281
140Hyperglycinuria (HP:0003108)1.65131262
141Congenital glaucoma (HP:0001087)1.64109291
142Round ear (HP:0100830)1.62812674
143Soft skin (HP:0000977)1.62636581
144Nonimmune hydrops fetalis (HP:0001790)1.62266503
145Neuronal loss in central nervous system (HP:0002529)1.61822994
146Hypertriglyceridemia (HP:0002155)1.61552365
147Enlarged penis (HP:0000040)1.61145408
148Abnormality of the Achilles tendon (HP:0005109)1.60205616
149Generalized aminoaciduria (HP:0002909)1.60006176
150Purpura (HP:0000979)1.59944028
151Difficulty running (HP:0009046)1.59912252
152Facial diplegia (HP:0001349)1.59595646
153Cardiovascular calcification (HP:0011915)1.58837293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.92847865
2ERN13.52166158
3PRPF4B3.34296308
4TGFBR22.98356461
5SIK12.51406589
6TIE12.16569503
7SMG12.08354778
8PKN22.03960235
9RIPK11.94174866
10ICK1.86441227
11INSRR1.82023188
12EPHB11.81387854
13FGFR41.81260333
14FRK1.77200297
15PTK61.74707654
16CAMK1D1.74276188
17FGFR21.73010509
18PDGFRA1.70770390
19CAMK1G1.65419187
20PIK3CG1.63777532
21MAP3K101.59905975
22MAP3K131.59209260
23EEF2K1.56264495
24MAP3K111.55567587
25BCKDK1.54046578
26JAK11.43388462
27TTN1.42558214
28TESK11.41431845
29WNK41.38883976
30TNK21.34974316
31MAP3K71.33847839
32LATS11.29396500
33CDC42BPA1.29237106
34FGFR31.28854947
35LRRK21.27874839
36TAOK31.25744385
37RIPK41.22739582
38TAOK11.19120654
39PRKCH1.17794099
40PDGFRB1.16428546
41TAOK21.14540097
42TYK21.14514067
43PRKD11.05935216
44DDR21.03128205
45EPHA31.02661701
46FES1.01393713
47MAP3K21.01126903
48RET1.00872652
49MYLK1.00117430
50TBK10.98296170
51CDK120.97948589
52PIK3CA0.97225101
53GRK60.96633656
54KSR20.96321355
55PRKD20.96270933
56SIK20.95075301
57SGK30.95053441
58MAP4K10.94238822
59DMPK0.93695940
60EPHB20.92985603
61ITK0.92524340
62FLT30.89528455
63HIPK20.89309552
64MAP3K60.85582804
65JAK20.85547827
66MST1R0.85508016
67CSK0.85020990
68RPS6KC10.84549686
69RPS6KL10.84549686
70ARAF0.83972671
71STK390.82935084
72TYRO30.81998379
73DYRK1B0.81980254
74MTOR0.81703736
75STK380.78964762
76FER0.78774716
77KIT0.78235059
78ZAP700.77975938
79LMTK20.77383307
80IRAK30.77060378
81PRKD30.76566164
82PTK20.74364466
83BLK0.74165042
84PDK10.73938911
85CDK90.72813008
86MAP2K30.71613083
87KDR0.70354648
88PRKAA20.68011066
89TRPM70.66979112
90WNK10.65611071
91SIK30.64552162
92MAPK70.64114493
93RPS6KA60.63876860
94MAP3K30.63833157
95BTK0.63233040
96MARK20.63161408
97STK100.63118519
98MAPK120.62056033
99NEK90.62046882
100RPS6KA20.60606195
101PAK60.60518898
102PTK2B0.60511430
103CSF1R0.59899738
104MET0.59112380
105SGK20.58065885
106CAMKK20.57298746
107GSK3A0.54921136
108ILK0.54591262
109MAPK110.54069904
110PAK20.53775384
111PAK40.53528042
112MAPK40.52991693
113CAMKK10.52756948
114IGF1R0.52721401
115ROCK10.52247667
116PHKG10.52243321
117PHKG20.52243321
118TGFBR10.51730857
119MAP3K10.51389936
120IRAK20.50680687
121EPHA20.49870690
122IRAK40.49851074
123PAK30.49795170
124UHMK10.49227268
125JAK30.48761742
126TESK20.48570525
127NTRK10.48344418
128PDPK10.47988582
129NLK0.47682587
130PRKG20.46865447
131BMX0.46122077
132MAPK150.46090650
133CDK60.45991889
134SGK2230.45672020
135SGK4940.45672020
136HCK0.45297275
137MAP2K20.43482231
138MAPKAPK30.42898387
139PIM20.39957528
140NME20.39358344
141FYN0.38746326
142MAP3K140.38579358

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.28230070
2Fatty acid degradation_Homo sapiens_hsa000712.08257194
3PPAR signaling pathway_Homo sapiens_hsa033201.90254379
4Primary bile acid biosynthesis_Homo sapiens_hsa001201.86976480
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82185314
6Notch signaling pathway_Homo sapiens_hsa043301.73505187
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.68580765
8Propanoate metabolism_Homo sapiens_hsa006401.64115576
9Fatty acid metabolism_Homo sapiens_hsa012121.59564384
10Complement and coagulation cascades_Homo sapiens_hsa046101.54886638
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51047756
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50096818
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46656969
14Tryptophan metabolism_Homo sapiens_hsa003801.44431008
15ECM-receptor interaction_Homo sapiens_hsa045121.42952102
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.36128218
17Insulin resistance_Homo sapiens_hsa049311.32407491
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.28969643
19ABC transporters_Homo sapiens_hsa020101.28400571
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27015901
21Staphylococcus aureus infection_Homo sapiens_hsa051501.26593102
22Prion diseases_Homo sapiens_hsa050201.24302943
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.24143228
24GnRH signaling pathway_Homo sapiens_hsa049121.21836124
25Protein digestion and absorption_Homo sapiens_hsa049741.21706580
26Focal adhesion_Homo sapiens_hsa045101.17688693
27Sulfur metabolism_Homo sapiens_hsa009201.16654252
28Arginine biosynthesis_Homo sapiens_hsa002201.15015014
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13504806
30Lysine degradation_Homo sapiens_hsa003101.12659350
31mTOR signaling pathway_Homo sapiens_hsa041501.11707588
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10343346
33Caffeine metabolism_Homo sapiens_hsa002321.09340542
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08005202
35Renal cell carcinoma_Homo sapiens_hsa052111.07298639
36Choline metabolism in cancer_Homo sapiens_hsa052311.06611609
37Butanoate metabolism_Homo sapiens_hsa006501.06413189
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.05279906
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04237251
40Bile secretion_Homo sapiens_hsa049761.02932990
41Other glycan degradation_Homo sapiens_hsa005111.02481346
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01716077
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01276394
44Endocytosis_Homo sapiens_hsa041441.00482160
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00060237
46Long-term potentiation_Homo sapiens_hsa047200.99991870
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.98579600
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98182237
49Leishmaniasis_Homo sapiens_hsa051400.97845460
50beta-Alanine metabolism_Homo sapiens_hsa004100.97667357
51Fatty acid biosynthesis_Homo sapiens_hsa000610.97277715
52ErbB signaling pathway_Homo sapiens_hsa040120.96725288
53Amoebiasis_Homo sapiens_hsa051460.96065388
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92879412
55Malaria_Homo sapiens_hsa051440.92871112
56Bladder cancer_Homo sapiens_hsa052190.91691479
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91303609
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90805314
59Hepatitis C_Homo sapiens_hsa051600.89233803
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.87156610
61Glycerolipid metabolism_Homo sapiens_hsa005610.85333686
62Inositol phosphate metabolism_Homo sapiens_hsa005620.84649942
63Peroxisome_Homo sapiens_hsa041460.82969179
64Tuberculosis_Homo sapiens_hsa051520.82648451
65TNF signaling pathway_Homo sapiens_hsa046680.81501819
66Chemokine signaling pathway_Homo sapiens_hsa040620.81113710
67Chronic myeloid leukemia_Homo sapiens_hsa052200.80051088
68Type II diabetes mellitus_Homo sapiens_hsa049300.79785644
69Lysosome_Homo sapiens_hsa041420.79664237
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79268657
71Histidine metabolism_Homo sapiens_hsa003400.79059570
72Platelet activation_Homo sapiens_hsa046110.78357578
73Fat digestion and absorption_Homo sapiens_hsa049750.77734822
74Chemical carcinogenesis_Homo sapiens_hsa052040.77181664
75Rap1 signaling pathway_Homo sapiens_hsa040150.77123757
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76356160
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75850855
78Synaptic vesicle cycle_Homo sapiens_hsa047210.75151988
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74632925
80T cell receptor signaling pathway_Homo sapiens_hsa046600.74165426
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73708488
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.73644822
83Starch and sucrose metabolism_Homo sapiens_hsa005000.72488250
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.72473839
85Dilated cardiomyopathy_Homo sapiens_hsa054140.71772179
86B cell receptor signaling pathway_Homo sapiens_hsa046620.71605873
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71319319
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70699864
89Melanogenesis_Homo sapiens_hsa049160.70015448
90MAPK signaling pathway_Homo sapiens_hsa040100.69764408
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69427808
92Sulfur relay system_Homo sapiens_hsa041220.69287485
93Renin secretion_Homo sapiens_hsa049240.69231890
94Colorectal cancer_Homo sapiens_hsa052100.68863019
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68527438
96Pertussis_Homo sapiens_hsa051330.67211566
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66956323
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66472660
99Proteoglycans in cancer_Homo sapiens_hsa052050.66404414
100Thyroid cancer_Homo sapiens_hsa052160.66207120
101Hepatitis B_Homo sapiens_hsa051610.65740656
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65247884
103AMPK signaling pathway_Homo sapiens_hsa041520.65124063
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64301812
105Cholinergic synapse_Homo sapiens_hsa047250.63987074
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63789369
107Toxoplasmosis_Homo sapiens_hsa051450.63376355
108Adherens junction_Homo sapiens_hsa045200.63297940
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62386601
110FoxO signaling pathway_Homo sapiens_hsa040680.62045084
111Pancreatic cancer_Homo sapiens_hsa052120.61727322
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61713026
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61540575
114Insulin signaling pathway_Homo sapiens_hsa049100.61016613
115Endometrial cancer_Homo sapiens_hsa052130.60950963
116Salmonella infection_Homo sapiens_hsa051320.59551018
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59531592
118Thyroid hormone synthesis_Homo sapiens_hsa049180.59235194
119Primary immunodeficiency_Homo sapiens_hsa053400.59185136
120Oxytocin signaling pathway_Homo sapiens_hsa049210.58548271
121Acute myeloid leukemia_Homo sapiens_hsa052210.58526861
122Vibrio cholerae infection_Homo sapiens_hsa051100.58338361
123Small cell lung cancer_Homo sapiens_hsa052220.57952810
124Fatty acid elongation_Homo sapiens_hsa000620.57490692
125Osteoclast differentiation_Homo sapiens_hsa043800.57274135
126Cocaine addiction_Homo sapiens_hsa050300.56808692
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.56690910
128Pancreatic secretion_Homo sapiens_hsa049720.56675210
129Selenocompound metabolism_Homo sapiens_hsa004500.56656691
130Axon guidance_Homo sapiens_hsa043600.56211549
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55946442
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55495323
133Retinol metabolism_Homo sapiens_hsa008300.55454721
134Dorso-ventral axis formation_Homo sapiens_hsa043200.55066124
135Apoptosis_Homo sapiens_hsa042100.54878756
136Influenza A_Homo sapiens_hsa051640.54227243
137Glioma_Homo sapiens_hsa052140.53132153
138Non-small cell lung cancer_Homo sapiens_hsa052230.52862836
139Prostate cancer_Homo sapiens_hsa052150.52625281
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.52123263
141Glucagon signaling pathway_Homo sapiens_hsa049220.50723093
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.50351715
143Prolactin signaling pathway_Homo sapiens_hsa049170.49565061
144Estrogen signaling pathway_Homo sapiens_hsa049150.48539212
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47936077
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47635204
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47518412
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46731775
149Phenylalanine metabolism_Homo sapiens_hsa003600.46148044
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.45985205
151Gastric acid secretion_Homo sapiens_hsa049710.45716931
152VEGF signaling pathway_Homo sapiens_hsa043700.45332619
153Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45166954
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44598024
155Insulin secretion_Homo sapiens_hsa049110.43822808

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