MXI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)4.00195762
2synaptic vesicle maturation (GO:0016188)3.61584475
3negative regulation of glial cell proliferation (GO:0060253)3.49255916
4microglial cell activation (GO:0001774)3.45005398
5layer formation in cerebral cortex (GO:0021819)3.37001163
6activated T cell proliferation (GO:0050798)3.33461142
7hemoglobin metabolic process (GO:0020027)3.29847980
8potassium ion import (GO:0010107)3.24279330
9oxygen transport (GO:0015671)3.22192080
10sodium ion export (GO:0071436)3.21402876
11cellular response to epinephrine stimulus (GO:0071872)3.21156724
12protoporphyrinogen IX metabolic process (GO:0046501)3.15061623
13negative regulation of inclusion body assembly (GO:0090084)3.11697437
14cellular response to monoamine stimulus (GO:0071868)3.11151966
15cellular response to catecholamine stimulus (GO:0071870)3.11151966
16gas transport (GO:0015669)3.10360617
17axon ensheathment in central nervous system (GO:0032291)3.08576505
18central nervous system myelination (GO:0022010)3.08576505
19locomotory exploration behavior (GO:0035641)3.08571631
20positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.06395874
21mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.06395874
22macroautophagy (GO:0016236)3.02267224
23histone H3-K9 demethylation (GO:0033169)2.99940373
24positive regulation of insulin receptor signaling pathway (GO:0046628)2.97308283
25peptidyl-tyrosine autophosphorylation (GO:0038083)2.96985437
26synaptic vesicle exocytosis (GO:0016079)2.94407493
27postsynaptic membrane organization (GO:0001941)2.93332913
28positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.91867742
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90527680
30neurotransmitter uptake (GO:0001504)2.89325620
31potassium ion homeostasis (GO:0055075)2.89261203
32negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.88554081
33negative regulation of cAMP-mediated signaling (GO:0043951)2.85675781
34L-amino acid import (GO:0043092)2.82714726
35exploration behavior (GO:0035640)2.81400537
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81345683
37regulation of voltage-gated calcium channel activity (GO:1901385)2.80977912
38positive regulation of dendritic spine morphogenesis (GO:0061003)2.80721246
39cell differentiation in hindbrain (GO:0021533)2.78375219
40amino acid import (GO:0043090)2.77995084
41gamma-aminobutyric acid transport (GO:0015812)2.76697659
42response to catecholamine (GO:0071869)2.76057152
43response to monoamine (GO:0071867)2.76057152
44auditory behavior (GO:0031223)2.75329944
45positive regulation of neurological system process (GO:0031646)2.74415985
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73739864
47regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73150194
48erythrocyte development (GO:0048821)2.72594188
49dendritic spine morphogenesis (GO:0060997)2.71591792
50response to epinephrine (GO:0071871)2.71060085
51protein K11-linked deubiquitination (GO:0035871)2.70925437
52synaptic vesicle endocytosis (GO:0048488)2.70106899
53regulation of dendritic spine morphogenesis (GO:0061001)2.69206293
54neuronal action potential propagation (GO:0019227)2.68677627
55phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67311971
56regulation of synaptic vesicle exocytosis (GO:2000300)2.66608155
57neutrophil mediated immunity (GO:0002446)2.61528892
58regulation of glial cell proliferation (GO:0060251)2.60821621
59neurotransmitter-gated ion channel clustering (GO:0072578)2.60018972
60long-term synaptic potentiation (GO:0060291)2.59331638
61regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.59312008
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.59312008
63neuron cell-cell adhesion (GO:0007158)2.58000123
64regulation of inositol phosphate biosynthetic process (GO:0010919)2.57032363
65regulation of neurotransmitter uptake (GO:0051580)2.55829317
66positive regulation of dendritic spine development (GO:0060999)2.55166315
67positive regulation of response to oxidative stress (GO:1902884)2.54492352
68positive regulation of cellular response to oxidative stress (GO:1900409)2.54492352
69dopamine biosynthetic process (GO:0042416)2.53068142
70myeloid leukocyte mediated immunity (GO:0002444)2.52637012
71eye photoreceptor cell differentiation (GO:0001754)2.50570322
72photoreceptor cell differentiation (GO:0046530)2.50570322
73positive regulation of neurotransmitter secretion (GO:0001956)2.49987335
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49296033
75detection of molecule of bacterial origin (GO:0032490)2.48681691
76vocalization behavior (GO:0071625)2.48363268
77regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.48168249
78regulation of dendritic spine development (GO:0060998)2.48152219
79protein localization to synapse (GO:0035418)2.47808502
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.43156602
81establishment of nucleus localization (GO:0040023)2.43142194
82regulation of neurotransmitter secretion (GO:0046928)2.41895532
83import into cell (GO:0098657)2.41022211
84regulation of synaptic vesicle transport (GO:1902803)2.40508161
85pyrimidine nucleobase catabolic process (GO:0006208)2.39653383
86positive T cell selection (GO:0043368)2.38589719
87negative regulation of immunoglobulin mediated immune response (GO:0002890)2.38009225
88negative regulation of B cell mediated immunity (GO:0002713)2.38009225
89membrane repolarization (GO:0086009)2.36682883
90response to insecticide (GO:0017085)2.35749704
91response to auditory stimulus (GO:0010996)2.35160488
92response to methylmercury (GO:0051597)2.34239343
93regulation of protein glycosylation (GO:0060049)2.34203575
94astrocyte differentiation (GO:0048708)2.34023029
95startle response (GO:0001964)2.33419306
96protein targeting to Golgi (GO:0000042)2.33413357
97positive regulation of granulocyte differentiation (GO:0030854)2.32044961
98peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.31182816
99negative regulation of cell killing (GO:0031342)2.30674044
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30674044
101axon ensheathment (GO:0008366)2.29836395
102ensheathment of neurons (GO:0007272)2.29836395
103myelination (GO:0042552)2.29628517
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.27665346
105mechanosensory behavior (GO:0007638)2.27301586
106macrophage activation (GO:0042116)2.27045909
107regulation of inclusion body assembly (GO:0090083)2.26973354
108response to lead ion (GO:0010288)2.26174395
109regulation of synapse structural plasticity (GO:0051823)2.25051341
110centrosome localization (GO:0051642)2.25035269
111cerebellar Purkinje cell differentiation (GO:0021702)2.24848362
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.24262038
113cerebellar granule cell differentiation (GO:0021707)2.23198651
114glutamate secretion (GO:0014047)2.22532158
115myelin maintenance (GO:0043217)2.22435079
116dendrite morphogenesis (GO:0048813)2.22290916
117establishment of protein localization to Golgi (GO:0072600)2.21967062
118response to pheromone (GO:0019236)2.21894465
119regulation of ARF protein signal transduction (GO:0032012)2.21302300
120adult walking behavior (GO:0007628)2.20989328
121gamma-aminobutyric acid signaling pathway (GO:0007214)2.18746539
122substrate-independent telencephalic tangential migration (GO:0021826)2.17917862
123substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.17917862
124presynaptic membrane assembly (GO:0097105)2.14502839
125negative regulation of protein localization to cell surface (GO:2000009)2.13887936
126neurotransmitter secretion (GO:0007269)2.13177420
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.13122019
128glutamate receptor signaling pathway (GO:0007215)2.12599164
129detection of light stimulus involved in sensory perception (GO:0050962)2.12063236
130detection of light stimulus involved in visual perception (GO:0050908)2.12063236
131activation of protein kinase A activity (GO:0034199)2.12022534
132regulation of beta-amyloid formation (GO:1902003)2.11808550
133mating behavior (GO:0007617)2.11364268
134retrograde transport, vesicle recycling within Golgi (GO:0000301)2.10809725
135positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.08666996
136nerve growth factor signaling pathway (GO:0038180)2.08484114
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.08142504
138positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.07847066
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.07671401
140creatine metabolic process (GO:0006600)2.07553304
141regulation of glutamate receptor signaling pathway (GO:1900449)2.06892554
142cerebral cortex radially oriented cell migration (GO:0021799)2.06667822
143membrane repolarization during action potential (GO:0086011)2.05427559
144negative regulation of potassium ion transmembrane transport (GO:1901380)2.05336149
145presynaptic membrane organization (GO:0097090)2.04129861
146negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.03005534
147acidic amino acid transport (GO:0015800)2.02162843
148positive regulation of potassium ion transport (GO:0043268)2.01831805
149synaptic vesicle docking involved in exocytosis (GO:0016081)2.00977482
150negative regulation of neurotransmitter secretion (GO:0046929)2.00890087
151negative regulation of neurotransmitter transport (GO:0051589)2.00125540
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.00101184
153positive regulation of dendrite development (GO:1900006)1.99873704
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.99408689
155myelination in peripheral nervous system (GO:0022011)1.99112768
156peripheral nervous system axon ensheathment (GO:0032292)1.99112768
157negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.98301188
158regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.97394191
159G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.96628075
160behavioral response to cocaine (GO:0048148)1.96396311
161L-glutamate transport (GO:0015813)1.94475589
162regulation of cardiac muscle cell contraction (GO:0086004)1.94084382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.87733980
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35624737
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30070835
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23042772
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22597247
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19047895
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19047895
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04913941
9* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04859283
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02680635
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00122403
12JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99193840
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97698336
14GATA1_22025678_ChIP-Seq_K562_Human1.96053124
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95877030
16* EZH2_27294783_Chip-Seq_ESCs_Mouse1.94509626
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94285952
18AR_21572438_ChIP-Seq_LNCaP_Human1.92930325
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.91737399
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88168990
21DROSHA_22980978_ChIP-Seq_HELA_Human1.86258198
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.86113177
23* RNF2_27304074_Chip-Seq_ESCs_Mouse1.83835431
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79589406
25GBX2_23144817_ChIP-Seq_PC3_Human1.60571457
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57738516
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55452470
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50777312
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.47047419
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46656816
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46521516
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45016155
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43324152
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.42479816
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42024730
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41334711
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40677014
38RUNX_20019798_ChIP-Seq_JUKART_Human1.39908477
39KDM2B_26808549_Chip-Seq_K562_Human1.39462964
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38108584
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36729850
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.36091940
43SCL_19346495_ChIP-Seq_HPC-7_Human1.35711579
44TAF15_26573619_Chip-Seq_HEK293_Human1.35084573
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30718582
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29969598
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28723380
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28696785
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28696785
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28653175
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23493539
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23236627
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22884471
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22739637
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21568522
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20028120
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.19913373
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17573598
59STAT3_23295773_ChIP-Seq_U87_Human1.16215591
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14339639
61REST_21632747_ChIP-Seq_MESCs_Mouse1.13869166
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.13484348
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.13116634
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12242320
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.10656133
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10651187
67P300_19829295_ChIP-Seq_ESCs_Human1.10393244
68GATA1_19941826_ChIP-Seq_K562_Human1.10207012
69* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09901106
70RNF2_27304074_Chip-Seq_NSC_Mouse1.08785621
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08541473
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08510912
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08387697
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08200179
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.08092313
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07705505
77TCF4_23295773_ChIP-Seq_U87_Human1.06964558
78* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06407871
79* SMAD3_21741376_ChIP-Seq_EPCs_Human1.05143017
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.05103647
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04770897
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04766730
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.04318865
84* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04006143
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.03817740
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.03303681
87AHR_22903824_ChIP-Seq_MCF-7_Human1.03192407
88RXR_22108803_ChIP-Seq_LS180_Human1.02172752
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01961111
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01612219
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01132102
92* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01011404
93VDR_22108803_ChIP-Seq_LS180_Human1.00744729
94* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00709076
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00329541
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99486118
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97752766
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96489159
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96393788
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.95789465
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95365467
102* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95288170
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94464755
104REST_18959480_ChIP-ChIP_MESCs_Mouse0.94056213
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.93601041
106* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93381343
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93178103
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93147593
109* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92499887
110SMAD4_21799915_ChIP-Seq_A2780_Human0.92350758
111* SMAD4_21741376_ChIP-Seq_EPCs_Human0.89736463
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89682408
113VDR_24787735_ChIP-Seq_THP-1_Human0.88755500
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85846972
115* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85658663
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85623402
117KLF5_25053715_ChIP-Seq_YYC3_Human0.85554929
118* GATA2_19941826_ChIP-Seq_K562_Human0.85054440
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84886006
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84886006
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.84839635
122TP53_18474530_ChIP-ChIP_U2OS_Human0.84763720
123TP53_16413492_ChIP-PET_HCT116_Human0.84265634
124* KDM2B_26808549_Chip-Seq_JURKAT_Human0.83655418
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83159593
126AR_25329375_ChIP-Seq_VCAP_Human0.82541483
127* KDM2B_26808549_Chip-Seq_DND41_Human0.81664668
128* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80459756
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80390956
130AR_19668381_ChIP-Seq_PC3_Human0.80370693
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.79663593
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79456574
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78952837
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77819977
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76980401
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.76268385
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76162828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.92847691
2MP0004859_abnormal_synaptic_plasticity3.47221441
3MP0003787_abnormal_imprinting3.45928890
4MP0002822_catalepsy3.06488315
5MP0010234_abnormal_vibrissa_follicle3.00685182
6MP0005377_hearing/vestibular/ear_phenot2.86066594
7MP0003878_abnormal_ear_physiology2.86066594
8MP0003880_abnormal_central_pattern2.78037449
9MP0005167_abnormal_blood-brain_barrier2.72237769
10MP0004885_abnormal_endolymph2.54986514
11MP0008260_abnormal_autophagy2.41808772
12MP0003635_abnormal_synaptic_transmissio2.30532678
13MP0001486_abnormal_startle_reflex2.22720730
14MP0009046_muscle_twitch2.13050863
15MP0005623_abnormal_meninges_morphology2.08907514
16MP0004742_abnormal_vestibular_system2.08285661
17MP0005174_abnormal_tail_pigmentation2.07452678
18MP0002064_seizures2.04874926
19MP0004270_analgesia2.01705915
20MP0000920_abnormal_myelination2.00593664
21MP0002796_impaired_skin_barrier1.94192547
22MP0003690_abnormal_glial_cell1.94051553
23MP0005551_abnormal_eye_electrophysiolog1.92900154
24MP0002638_abnormal_pupillary_reflex1.89430406
25MP0003303_peritoneal_inflammation1.84775759
26MP0009745_abnormal_behavioral_response1.83971612
27MP0008569_lethality_at_weaning1.77521456
28MP0003879_abnormal_hair_cell1.76203477
29MP0004043_abnormal_pH_regulation1.75261671
30MP0001984_abnormal_olfaction1.75118309
31MP0002063_abnormal_learning/memory/cond1.70560127
32MP0008877_abnormal_DNA_methylation1.70321111
33MP0003329_amyloid_beta_deposits1.66556981
34MP0003656_abnormal_erythrocyte_physiolo1.59690485
35MP0002090_abnormal_vision1.59667358
36MP0005409_darkened_coat_color1.57987632
37MP0002272_abnormal_nervous_system1.57609993
38MP0004147_increased_porphyrin_level1.57146745
39MP0003136_yellow_coat_color1.53873056
40MP0003122_maternal_imprinting1.51874974
41MP0000778_abnormal_nervous_system1.49991688
42MP0003075_altered_response_to1.47948789
43MP0000015_abnormal_ear_pigmentation1.47894690
44MP0001485_abnormal_pinna_reflex1.46463608
45MP0003121_genomic_imprinting1.46170301
46MP0002572_abnormal_emotion/affect_behav1.42270167
47MP0001440_abnormal_grooming_behavior1.42072607
48MP0003300_gastrointestinal_ulcer1.38805867
49MP0005410_abnormal_fertilization1.37319447
50MP0005075_abnormal_melanosome_morpholog1.36111888
51MP0002734_abnormal_mechanical_nocicepti1.29097683
52MP0002067_abnormal_sensory_capabilities1.28499233
53MP0000751_myopathy1.26585442
54MP0003633_abnormal_nervous_system1.24847097
55MP0002009_preneoplasia1.24456173
56MP0002909_abnormal_adrenal_gland1.24080885
57MP0003634_abnormal_glial_cell1.22582975
58MP0003950_abnormal_plasma_membrane1.18782834
59MP0002095_abnormal_skin_pigmentation1.18529216
60MP0003172_abnormal_lysosome_physiology1.18067865
61MP0001905_abnormal_dopamine_level1.17876833
62MP0005187_abnormal_penis_morphology1.17759456
63MP0004484_altered_response_of1.14495685
64MP0010678_abnormal_skin_adnexa1.13480730
65MP0004185_abnormal_adipocyte_glucose1.12763268
66MP0001502_abnormal_circadian_rhythm1.11470707
67MP0004142_abnormal_muscle_tone1.08852554
68MP0002735_abnormal_chemical_nociception1.07449601
69MP0002882_abnormal_neuron_morphology1.07135703
70MP0004130_abnormal_muscle_cell1.06335549
71MP0006138_congestive_heart_failure1.06007524
72MP0003631_nervous_system_phenotype1.05419745
73MP0000604_amyloidosis1.03469268
74MP0003724_increased_susceptibility_to1.03077033
75MP0003221_abnormal_cardiomyocyte_apopto1.01912015
76MP0006276_abnormal_autonomic_nervous0.99903964
77MP0005253_abnormal_eye_physiology0.99683552
78MP0005423_abnormal_somatic_nervous0.98861864
79MP0002229_neurodegeneration0.98761515
80MP0002557_abnormal_social/conspecific_i0.98584659
81MP0008961_abnormal_basal_metabolism0.97744271
82MP0004858_abnormal_nervous_system0.97664676
83MP0005386_behavior/neurological_phenoty0.97272436
84MP0004924_abnormal_behavior0.97272436
85MP0004883_abnormal_blood_vessel0.97003935
86MP0005501_abnormal_skin_physiology0.96967544
87MP0001968_abnormal_touch/_nociception0.96586291
88MP0000955_abnormal_spinal_cord0.96411578
89MP0003011_delayed_dark_adaptation0.92540670
90MP0001970_abnormal_pain_threshold0.91489163
91MP0000579_abnormal_nail_morphology0.91308276
92MP0001501_abnormal_sleep_pattern0.90831594
93MP0005171_absent_coat_pigmentation0.89301475
94MP0002098_abnormal_vibrissa_morphology0.87921973
95MP0005451_abnormal_body_composition0.87486022
96MP0002653_abnormal_ependyma_morphology0.86889000
97MP0001765_abnormal_ion_homeostasis0.86758662
98MP0000427_abnormal_hair_cycle0.85518337
99MP0006072_abnormal_retinal_apoptosis0.85422110
100MP0002332_abnormal_exercise_endurance0.83944356
101MP0002066_abnormal_motor_capabilities/c0.83558402
102MP0004811_abnormal_neuron_physiology0.83396568
103MP0003632_abnormal_nervous_system0.83174627
104MP0001963_abnormal_hearing_physiology0.83032926
105MP0001666_abnormal_nutrient_absorption0.82265252
106MP0003123_paternal_imprinting0.80063687
107MP0003191_abnormal_cellular_cholesterol0.79831534
108MP0003453_abnormal_keratinocyte_physiol0.78143995
109MP0005195_abnormal_posterior_eye0.78002720
110MP0001851_eye_inflammation0.77106599
111MP0001177_atelectasis0.75670023
112MP0008874_decreased_physiological_sensi0.75095332
113MP0004215_abnormal_myocardial_fiber0.74867530
114MP0002971_abnormal_brown_adipose0.74754755
115MP0004145_abnormal_muscle_electrophysio0.72381989
116MP0005535_abnormal_body_temperature0.72025670
117MP0001879_abnormal_lymphatic_vessel0.70828404
118MP0002152_abnormal_brain_morphology0.70525779
119MP0000647_abnormal_sebaceous_gland0.69602557
120MP0005620_abnormal_muscle_contractility0.69334216
121MP0002752_abnormal_somatic_nervous0.68795053
122MP0005083_abnormal_biliary_tract0.67427890
123MP0004036_abnormal_muscle_relaxation0.67268253
124MP0002733_abnormal_thermal_nociception0.67056065
125MP0003646_muscle_fatigue0.66675187
126MP0008995_early_reproductive_senescence0.64748528
127MP0002928_abnormal_bile_duct0.64566140
128MP0005646_abnormal_pituitary_gland0.64357814
129MP0004381_abnormal_hair_follicle0.64306484
130MP0003183_abnormal_peptide_metabolism0.64054535
131MP0005310_abnormal_salivary_gland0.63337138
132MP0001324_abnormal_eye_pigmentation0.61259208
133MP0000631_abnormal_neuroendocrine_gland0.55983379
134MP0002184_abnormal_innervation0.55459734
135MP0003938_abnormal_ear_development0.54244112

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.70077083
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.80247545
3Metabolic alkalosis (HP:0200114)4.28459385
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.20068286
5Neurofibrillary tangles (HP:0002185)3.60957188
6Visual hallucinations (HP:0002367)3.48345514
7Focal motor seizures (HP:0011153)3.45886751
8Microcytic anemia (HP:0001935)3.29265259
9Myokymia (HP:0002411)3.26421543
10Action tremor (HP:0002345)3.17205524
11Exercise-induced myalgia (HP:0003738)3.07086776
12Intention tremor (HP:0002080)3.03657355
13Increased circulating renin level (HP:0000848)3.01910157
14Abnormality of chloride homeostasis (HP:0011422)2.99117860
15Hypokalemic alkalosis (HP:0001949)2.97201178
16Hypochromic anemia (HP:0001931)2.95421321
17Papillary thyroid carcinoma (HP:0002895)2.93628883
18Epileptic encephalopathy (HP:0200134)2.91254832
19Exercise-induced muscle cramps (HP:0003710)2.89158004
20Supranuclear gaze palsy (HP:0000605)2.85458622
21Papilledema (HP:0001085)2.82693341
22Clumsiness (HP:0002312)2.81203234
23Hyperactive renin-angiotensin system (HP:0000841)2.79919796
24Cholecystitis (HP:0001082)2.74523672
25Abnormal gallbladder physiology (HP:0012438)2.74523672
26Cerebral inclusion bodies (HP:0100314)2.72685135
27Focal seizures (HP:0007359)2.70357705
28Blue irides (HP:0000635)2.69859036
29Dysdiadochokinesis (HP:0002075)2.66783494
30Abnormality of macular pigmentation (HP:0008002)2.61611871
31Slow saccadic eye movements (HP:0000514)2.59341908
32Hypomagnesemia (HP:0002917)2.56136680
33Dysmetria (HP:0001310)2.54044484
34Genetic anticipation (HP:0003743)2.52921036
35Diplopia (HP:0000651)2.49120963
36Abnormality of binocular vision (HP:0011514)2.49120963
37Poikilocytosis (HP:0004447)2.48106697
38Ankle clonus (HP:0011448)2.47885319
39Generalized tonic-clonic seizures (HP:0002069)2.47314915
40Absent/shortened dynein arms (HP:0200106)2.42986132
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.42986132
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.41875277
43Abnormal drinking behavior (HP:0030082)2.39873778
44Polydipsia (HP:0001959)2.39873778
45Osteomalacia (HP:0002749)2.39712154
46Megalencephaly (HP:0001355)2.39255421
47Depression (HP:0000716)2.38895518
48Gastrointestinal infarctions (HP:0005244)2.38840994
49Hyperaldosteronism (HP:0000859)2.36844603
50Hemiparesis (HP:0001269)2.36740870
51Progressive cerebellar ataxia (HP:0002073)2.36118594
52Cone-rod dystrophy (HP:0000548)2.32995236
53Gaze-evoked nystagmus (HP:0000640)2.32003664
54Abnormal urine output (HP:0012590)2.29455223
55Obstructive sleep apnea (HP:0002870)2.29380215
56Polyuria (HP:0000103)2.28684971
57Hyporeflexia of lower limbs (HP:0002600)2.26798120
58Macroorchidism (HP:0000053)2.22772399
59Thickened helices (HP:0000391)2.20542883
60Recurrent bacterial skin infections (HP:0005406)2.18803802
61Central scotoma (HP:0000603)2.18240038
62Urinary bladder sphincter dysfunction (HP:0002839)2.17397389
63Synostosis involving the elbow (HP:0003938)2.15994754
64Humeroradial synostosis (HP:0003041)2.15994754
65Annular pancreas (HP:0001734)2.13955746
66Increased IgE level (HP:0003212)2.13463764
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13127214
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.13127214
69Hyperkalemia (HP:0002153)2.12249298
70Oligodactyly (hands) (HP:0001180)2.11293603
71Ocular albinism (HP:0001107)2.11152872
72Atonic seizures (HP:0010819)2.10950848
73Abnormality of renin-angiotensin system (HP:0000847)2.10121523
74Hyperventilation (HP:0002883)2.09755487
75Abnormality of renal excretion (HP:0011036)2.09297237
76Foot dorsiflexor weakness (HP:0009027)2.07448400
77Abnormality of the foot musculature (HP:0001436)2.06989761
78Acanthocytosis (HP:0001927)2.06945694
79Postural instability (HP:0002172)2.05592234
80Drooling (HP:0002307)2.04395718
81Aplasia involving bones of the upper limbs (HP:0009823)2.03371311
82Aplasia of the phalanges of the hand (HP:0009802)2.03371311
83Aplasia involving bones of the extremities (HP:0009825)2.03371311
84Abolished electroretinogram (ERG) (HP:0000550)2.03336266
85Spastic gait (HP:0002064)2.03140620
86Eczematoid dermatitis (HP:0000976)2.02745333
87Truncal ataxia (HP:0002078)2.02424067
88Hypoplasia of the iris (HP:0007676)2.01902674
89Anxiety (HP:0000739)2.01863735
90Bradykinesia (HP:0002067)2.00827917
91Onion bulb formation (HP:0003383)2.00257777
92Paralysis (HP:0003470)1.99668546
93Excessive salivation (HP:0003781)1.99334478
94Germ cell neoplasia (HP:0100728)1.98935373
95Cholelithiasis (HP:0001081)1.98243344
96Polyphagia (HP:0002591)1.98189438
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97531962
98Abnormality of incisor morphology (HP:0011063)1.97475933
99Abnormality of magnesium homeostasis (HP:0004921)1.97433810
100Broad-based gait (HP:0002136)1.96203087
101Testicular neoplasm (HP:0010788)1.94393526
102Amblyopia (HP:0000646)1.93420537
103Iris hypopigmentation (HP:0007730)1.92801343
104Delusions (HP:0000746)1.91865605
105Absent speech (HP:0001344)1.91030404
106Abnormal hemoglobin (HP:0011902)1.90335778
107Dysmetric saccades (HP:0000641)1.88649992
108Axonal loss (HP:0003447)1.87817703
109Resting tremor (HP:0002322)1.86792308
110Scanning speech (HP:0002168)1.86260758
111Sensory axonal neuropathy (HP:0003390)1.85888553
112Abnormal eating behavior (HP:0100738)1.85684403
113Abnormality of the corticospinal tract (HP:0002492)1.84079567
114Abnormal gallbladder morphology (HP:0012437)1.83742285
115Reticulocytosis (HP:0001923)1.83713422
116Rapidly progressive (HP:0003678)1.83348631
117Neuronal loss in central nervous system (HP:0002529)1.83047103
118Ventricular fibrillation (HP:0001663)1.82971483
119Insidious onset (HP:0003587)1.82933820
120Termporal pattern (HP:0011008)1.82933820
121Insomnia (HP:0100785)1.82235692
122Difficulty running (HP:0009046)1.80491236
123Abnormality of the lower motor neuron (HP:0002366)1.80446361
124Subacute progressive viral hepatitis (HP:0006572)1.80375149
125Polycythemia (HP:0001901)1.79702429
126Parakeratosis (HP:0001036)1.79683059
127Stereotypic behavior (HP:0000733)1.79469194
128Hemiplegia (HP:0002301)1.79012369
129Absence seizures (HP:0002121)1.78977999
130Decreased motor nerve conduction velocity (HP:0003431)1.78718353
131Increased CSF protein (HP:0002922)1.78708179
132Febrile seizures (HP:0002373)1.78492977
133Truncal obesity (HP:0001956)1.78436318
134Scotoma (HP:0000575)1.77999793
135Retrobulbar optic neuritis (HP:0100654)1.77152088
136Optic neuritis (HP:0100653)1.77152088
137Adrenal overactivity (HP:0002717)1.76411138
138Urinary urgency (HP:0000012)1.75349028
139Alkalosis (HP:0001948)1.75203670
140Tetany (HP:0001281)1.73821244
141Generalized hypopigmentation of hair (HP:0011358)1.73704631
142Abnormal respiratory motile cilium physiology (HP:0012261)1.73492061
143Abnormality of nail color (HP:0100643)1.73013699
144Pheochromocytoma (HP:0002666)1.72990147
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72835038
146Thyroid carcinoma (HP:0002890)1.72258779
147Peripheral hypomyelination (HP:0007182)1.71507748
148Dialeptic seizures (HP:0011146)1.71338559
149Rigidity (HP:0002063)1.71336521
150Hamartoma (HP:0010566)1.71327050
151Abnormal ciliary motility (HP:0012262)1.70910605
152Abnormality of secondary sexual hair (HP:0009888)1.70593762
153Abnormality of the axillary hair (HP:0100134)1.70593762
154Sleep apnea (HP:0010535)1.67856732
155Arthropathy (HP:0003040)1.67120714
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.66662913
157Aqueductal stenosis (HP:0002410)1.65182089
158Inappropriate behavior (HP:0000719)1.64671302
159T lymphocytopenia (HP:0005403)1.62482532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.01580682
2EPHA42.61780794
3OXSR12.30580028
4KSR22.28045500
5RIPK12.18712040
6STK392.05564343
7PLK21.94828395
8PRPF4B1.92177946
9BMX1.91889972
10MST1R1.90526718
11TYRO31.88462923
12CAMK1G1.88008620
13FRK1.85254047
14EPHB11.82659137
15GRK51.80730996
16SGK2231.78640529
17SGK4941.78640529
18WNK11.77559675
19MAP3K21.75266547
20PAK61.69377384
21WNK41.68818780
22TRIB31.68359671
23CASK1.53535362
24CDK191.52140843
25CAMK1D1.49607676
26KSR11.47803903
27DAPK21.47126924
28NME11.41395602
29RIPK41.39580010
30NLK1.39059346
31DMPK1.36926352
32ICK1.36832126
33PHKG21.27380224
34PHKG11.27380224
35TAOK21.25416277
36FES1.25361547
37MARK21.22548563
38YES11.21602511
39SGK31.19649341
40MAP2K21.19416727
41SIK21.19178040
42FGR1.17716492
43PDPK11.16070136
44MAP3K91.15761356
45CAMKK11.15174448
46STK111.14902944
47MAP2K31.09791979
48PIK3CA1.09254069
49PTK61.09240543
50ERBB21.07885197
51IRAK21.07301127
52MAPK131.06833778
53PKN21.05964334
54SGK21.05334705
55GRK11.04768329
56IRAK11.00218728
57PKN10.99581536
58NTRK20.96862729
59FGFR30.96717285
60CDK50.95860244
61RET0.93388531
62IKBKE0.92943282
63PINK10.91093284
64TNIK0.91086672
65CLK10.88639508
66HIPK20.88308735
67CAMKK20.88186553
68MET0.87701299
69MAP3K30.87118585
70MAP3K60.86146227
71MAP3K40.84434958
72MAPK120.82639768
73STK40.82571919
74MARK30.81846806
75PDK10.81150405
76MINK10.79999308
77BMPR20.78634340
78SYK0.76891566
79TNK20.76132816
80DYRK1B0.75710105
81EPHB20.75272245
82BLK0.74454881
83MAP3K10.73389896
84MAP2K10.72388331
85MAP3K70.72131929
86LRRK20.72046002
87TAOK30.71464812
88SGK10.71453818
89TAOK10.71417078
90UHMK10.70529315
91GRK60.70419447
92PIM10.69760571
93MAPK150.68827803
94STK380.68738259
95TRPM70.67962843
96IRAK40.67459292
97LMTK20.67298190
98PBK0.64609827
99CDK90.64177453
100NEK60.63612645
101PNCK0.63259025
102INSRR0.62198207
103PTK2B0.61622954
104BMPR1B0.61570439
105NTRK30.60710676
106RAF10.60274891
107CAMK2A0.59410781
108ACVR1B0.58534106
109JAK20.58049642
110PAK30.57995846
111WNK30.57634002
112ROCK20.57355294
113NTRK10.56891412
114PRKD20.56225955
115MAP2K70.55886048
116CDK30.54989358
117PRKCH0.54641648
118BRD40.53731741
119MAPK100.53194202
120FGFR20.52313453
121MAP3K50.51888465
122PRKCZ0.51837650
123MAPK70.51010793
124PRKD30.49249915
125CSK0.49031033
126CDK140.48737661
127MAP2K40.48390144
128FYN0.47636443
129PDGFRB0.47574636
130JAK10.46306016
131CAMK10.45228269
132PRKAA20.45112584
133MST40.44695995
134DYRK1A0.44442281
135MAP2K60.43793958
136ADRBK10.43659516
137CAMK40.43305174
138PRKCG0.43285769
139PRKCE0.43075641
140MARK10.43070869
141ROCK10.42273033

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009101.97313061
2Salivary secretion_Homo sapiens_hsa049701.78659488
3GABAergic synapse_Homo sapiens_hsa047271.75345830
4Glutamatergic synapse_Homo sapiens_hsa047241.69469837
5Morphine addiction_Homo sapiens_hsa050321.69207849
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68124867
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62046642
8Gastric acid secretion_Homo sapiens_hsa049711.61324841
9Mineral absorption_Homo sapiens_hsa049781.60233763
10Circadian entrainment_Homo sapiens_hsa047131.58959608
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58361741
12Synaptic vesicle cycle_Homo sapiens_hsa047211.55829792
13Olfactory transduction_Homo sapiens_hsa047401.53007284
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41799483
15Renin secretion_Homo sapiens_hsa049241.41605470
16Nicotine addiction_Homo sapiens_hsa050331.37189375
17FoxO signaling pathway_Homo sapiens_hsa040681.36814397
18Dorso-ventral axis formation_Homo sapiens_hsa043201.34177442
19Bile secretion_Homo sapiens_hsa049761.32004455
20Long-term potentiation_Homo sapiens_hsa047201.26413253
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26319286
22Cholinergic synapse_Homo sapiens_hsa047251.24230840
23Dopaminergic synapse_Homo sapiens_hsa047281.19084975
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17030208
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14750827
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12226135
27Long-term depression_Homo sapiens_hsa047301.11504260
28Oxytocin signaling pathway_Homo sapiens_hsa049211.11393947
29mTOR signaling pathway_Homo sapiens_hsa041501.10650431
30Axon guidance_Homo sapiens_hsa043601.10130030
31Renal cell carcinoma_Homo sapiens_hsa052111.05461388
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05437643
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04484342
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.04366846
35cAMP signaling pathway_Homo sapiens_hsa040241.00858726
36Prolactin signaling pathway_Homo sapiens_hsa049171.00294224
37Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99798978
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98669015
39Phospholipase D signaling pathway_Homo sapiens_hsa040720.98526393
40B cell receptor signaling pathway_Homo sapiens_hsa046620.98476631
41GnRH signaling pathway_Homo sapiens_hsa049120.96558577
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95389075
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95101791
44Serotonergic synapse_Homo sapiens_hsa047260.94608271
45Collecting duct acid secretion_Homo sapiens_hsa049660.94322466
46Pancreatic secretion_Homo sapiens_hsa049720.93726761
47T cell receptor signaling pathway_Homo sapiens_hsa046600.92919612
48Regulation of autophagy_Homo sapiens_hsa041400.92616807
49Notch signaling pathway_Homo sapiens_hsa043300.92199979
50Taste transduction_Homo sapiens_hsa047420.91716152
51Estrogen signaling pathway_Homo sapiens_hsa049150.91172986
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90802627
53Gap junction_Homo sapiens_hsa045400.88714438
54Choline metabolism in cancer_Homo sapiens_hsa052310.87778984
55AMPK signaling pathway_Homo sapiens_hsa041520.87756912
56Amphetamine addiction_Homo sapiens_hsa050310.86008845
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85521234
58Insulin secretion_Homo sapiens_hsa049110.85215278
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85035340
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84015605
61ErbB signaling pathway_Homo sapiens_hsa040120.83547668
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.83066667
63Fatty acid biosynthesis_Homo sapiens_hsa000610.81448195
64Phototransduction_Homo sapiens_hsa047440.79585569
65Glioma_Homo sapiens_hsa052140.79416858
66PPAR signaling pathway_Homo sapiens_hsa033200.78770221
67VEGF signaling pathway_Homo sapiens_hsa043700.78414774
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77806572
69Calcium signaling pathway_Homo sapiens_hsa040200.77767315
70Cocaine addiction_Homo sapiens_hsa050300.77527300
71Melanogenesis_Homo sapiens_hsa049160.76892395
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76369688
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.76179550
74Malaria_Homo sapiens_hsa051440.75663788
75Cardiac muscle contraction_Homo sapiens_hsa042600.75609676
76Type II diabetes mellitus_Homo sapiens_hsa049300.74526311
77Pancreatic cancer_Homo sapiens_hsa052120.74206190
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74132194
79Dilated cardiomyopathy_Homo sapiens_hsa054140.72691481
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72586276
81Sphingolipid metabolism_Homo sapiens_hsa006000.72502816
82Chronic myeloid leukemia_Homo sapiens_hsa052200.71937787
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71518456
84Rap1 signaling pathway_Homo sapiens_hsa040150.70270226
85Tight junction_Homo sapiens_hsa045300.67418875
86Ras signaling pathway_Homo sapiens_hsa040140.67155805
87Endocytosis_Homo sapiens_hsa041440.66485568
88Chemokine signaling pathway_Homo sapiens_hsa040620.66456979
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66206170
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.64611335
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63526958
92Acute myeloid leukemia_Homo sapiens_hsa052210.63395360
93Rheumatoid arthritis_Homo sapiens_hsa053230.60081779
94Colorectal cancer_Homo sapiens_hsa052100.59743043
95Ovarian steroidogenesis_Homo sapiens_hsa049130.58222984
96Thyroid hormone synthesis_Homo sapiens_hsa049180.56610304
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.56404421
98Circadian rhythm_Homo sapiens_hsa047100.56181781
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56050876
100Insulin signaling pathway_Homo sapiens_hsa049100.55858987
101Prostate cancer_Homo sapiens_hsa052150.55743634
102ABC transporters_Homo sapiens_hsa020100.55021607
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54279343
104Wnt signaling pathway_Homo sapiens_hsa043100.53881763
105MAPK signaling pathway_Homo sapiens_hsa040100.53639204
106Insulin resistance_Homo sapiens_hsa049310.53471033
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.53399197
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52856153
109Salmonella infection_Homo sapiens_hsa051320.52581652
110Platelet activation_Homo sapiens_hsa046110.51793445
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51294341
112Ether lipid metabolism_Homo sapiens_hsa005650.50327167
113HIF-1 signaling pathway_Homo sapiens_hsa040660.49251254
114Inositol phosphate metabolism_Homo sapiens_hsa005620.48424771
115Amoebiasis_Homo sapiens_hsa051460.47368591
116Alcoholism_Homo sapiens_hsa050340.45942094
117Vitamin digestion and absorption_Homo sapiens_hsa049770.45554663
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45312324
119Non-small cell lung cancer_Homo sapiens_hsa052230.44728287
120Osteoclast differentiation_Homo sapiens_hsa043800.44682059
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44280959
122Glycerolipid metabolism_Homo sapiens_hsa005610.44237663
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43517302
124Proteoglycans in cancer_Homo sapiens_hsa052050.42995306
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.42457971
126Arginine biosynthesis_Homo sapiens_hsa002200.41337580
127Endometrial cancer_Homo sapiens_hsa052130.40788642

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