

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein heterotrimerization (GO:0070208) | 5.49237259 |
| 2 | collagen fibril organization (GO:0030199) | 5.10776344 |
| 3 | chondrocyte proliferation (GO:0035988) | 4.99526830 |
| 4 | bone trabecula formation (GO:0060346) | 4.77589227 |
| 5 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 4.76118289 |
| 6 | axon extension involved in axon guidance (GO:0048846) | 4.76118289 |
| 7 | sequestering of extracellular ligand from receptor (GO:0035581) | 4.62961199 |
| 8 | metanephric mesenchyme development (GO:0072075) | 4.41115892 |
| 9 | kidney mesenchyme development (GO:0072074) | 4.21436870 |
| 10 | glomerular basement membrane development (GO:0032836) | 3.95949121 |
| 11 | endodermal cell differentiation (GO:0035987) | 3.82930934 |
| 12 | ganglion development (GO:0061548) | 3.81071686 |
| 13 | outer ear morphogenesis (GO:0042473) | 3.80353034 |
| 14 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 3.68821179 |
| 15 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.65649234 |
| 16 | collagen metabolic process (GO:0032963) | 3.44903131 |
| 17 | wound healing, spreading of epidermal cells (GO:0035313) | 3.43631978 |
| 18 | basement membrane organization (GO:0071711) | 3.39068388 |
| 19 | collagen catabolic process (GO:0030574) | 3.38096229 |
| 20 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 3.35958376 |
| 21 | extracellular fibril organization (GO:0043206) | 3.30195801 |
| 22 | dermatan sulfate biosynthetic process (GO:0030208) | 3.28923844 |
| 23 | lymphangiogenesis (GO:0001946) | 3.27764020 |
| 24 | craniofacial suture morphogenesis (GO:0097094) | 3.27098568 |
| 25 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.26723170 |
| 26 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.25383664 |
| 27 | cell migration involved in heart development (GO:0060973) | 3.25318400 |
| 28 | paraxial mesoderm development (GO:0048339) | 3.14247810 |
| 29 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.14205436 |
| 30 | negative regulation of fatty acid transport (GO:2000192) | 3.11197577 |
| 31 | multicellular organismal catabolic process (GO:0044243) | 3.09765252 |
| 32 | negative regulation of embryonic development (GO:0045992) | 3.07751987 |
| 33 | middle ear morphogenesis (GO:0042474) | 3.06637469 |
| 34 | extracellular regulation of signal transduction (GO:1900115) | 3.06381542 |
| 35 | extracellular negative regulation of signal transduction (GO:1900116) | 3.06381542 |
| 36 | negative regulation of chondrocyte differentiation (GO:0032331) | 3.05359908 |
| 37 | plasma membrane repair (GO:0001778) | 3.03736178 |
| 38 | multicellular organismal metabolic process (GO:0044236) | 3.03645488 |
| 39 | dermatan sulfate metabolic process (GO:0030205) | 3.01714459 |
| 40 | positive regulation of gastrulation (GO:2000543) | 2.99012996 |
| 41 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.98903011 |
| 42 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.97644774 |
| 43 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.97087497 |
| 44 | cardiac myofibril assembly (GO:0055003) | 2.96290724 |
| 45 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.95593180 |
| 46 | mesenchyme morphogenesis (GO:0072132) | 2.95561821 |
| 47 | camera-type eye morphogenesis (GO:0048593) | 2.95211687 |
| 48 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.93789514 |
| 49 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.93349566 |
| 50 | hippo signaling (GO:0035329) | 2.88252327 |
| 51 | cell proliferation involved in metanephros development (GO:0072203) | 2.87075419 |
| 52 | smooth muscle tissue development (GO:0048745) | 2.86354905 |
| 53 | skin morphogenesis (GO:0043589) | 2.84552195 |
| 54 | extracellular matrix disassembly (GO:0022617) | 2.83378994 |
| 55 | venous blood vessel morphogenesis (GO:0048845) | 2.79100672 |
| 56 | cell adhesion mediated by integrin (GO:0033627) | 2.76558230 |
| 57 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 2.73392080 |
| 58 | substrate-dependent cell migration (GO:0006929) | 2.72904469 |
| 59 | embryonic camera-type eye development (GO:0031076) | 2.71879726 |
| 60 | glomerular visceral epithelial cell development (GO:0072015) | 2.71704965 |
| 61 | protein localization to cell surface (GO:0034394) | 2.69377545 |
| 62 | negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394) | 2.67937433 |
| 63 | eye morphogenesis (GO:0048592) | 2.67288442 |
| 64 | fibril organization (GO:0097435) | 2.65407156 |
| 65 | face morphogenesis (GO:0060325) | 2.63257624 |
| 66 | myoblast fusion (GO:0007520) | 2.63032493 |
| 67 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 2.62643315 |
| 68 | blood vessel maturation (GO:0001955) | 2.61459447 |
| 69 | pattern specification involved in kidney development (GO:0061004) | 2.61269500 |
| 70 | chondrocyte development (GO:0002063) | 2.61213288 |
| 71 | mesenchyme development (GO:0060485) | 2.60387856 |
| 72 | negative regulation of catenin import into nucleus (GO:0035414) | 2.59772226 |
| 73 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.59451463 |
| 74 | endothelial cell morphogenesis (GO:0001886) | 2.59008474 |
| 75 | facial nerve structural organization (GO:0021612) | 2.57841408 |
| 76 | cell proliferation involved in kidney development (GO:0072111) | 2.57745906 |
| 77 | glomerulus development (GO:0032835) | 2.57083448 |
| 78 | lymph vessel development (GO:0001945) | 2.57031711 |
| 79 | negative regulation of cartilage development (GO:0061037) | 2.57001076 |
| 80 | cartilage morphogenesis (GO:0060536) | 2.56429042 |
| 81 | extracellular matrix organization (GO:0030198) | 2.55877431 |
| 82 | extracellular structure organization (GO:0043062) | 2.54957873 |
| 83 | regulation of tight junction assembly (GO:2000810) | 2.54256240 |
| 84 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.53428404 |
| 85 | cellular response to vitamin (GO:0071295) | 2.52479984 |
| 86 | neural crest cell development (GO:0014032) | 2.52226888 |
| 87 | regulation of mesenchymal cell proliferation (GO:0010464) | 2.52187538 |
| 88 | positive regulation of mesenchymal cell proliferation (GO:0002053) | 2.51631491 |
| 89 | endocardial cushion development (GO:0003197) | 2.50482878 |
| 90 | extracellular matrix assembly (GO:0085029) | 2.48973768 |
| 91 | glomerular filtration (GO:0003094) | 2.48508655 |
| 92 | syncytium formation (GO:0006949) | 2.47920324 |
| 93 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.47651166 |
| 94 | outflow tract septum morphogenesis (GO:0003148) | 2.46702267 |
| 95 | myofibril assembly (GO:0030239) | 2.46374262 |
| 96 | protein retention in ER lumen (GO:0006621) | 2.45830926 |
| 97 | regulation of heart morphogenesis (GO:2000826) | 2.45191499 |
| 98 | renal filtration (GO:0097205) | 2.44872654 |
| 99 | axon extension (GO:0048675) | 2.44214586 |
| 100 | adhesion of symbiont to host (GO:0044406) | 2.44004571 |
| 101 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.43836052 |
| 102 | mesonephric tubule development (GO:0072164) | 2.43516019 |
| 103 | cellular response to interferon-alpha (GO:0035457) | 2.43454997 |
| 104 | embryonic skeletal system development (GO:0048706) | 2.43317532 |
| 105 | type B pancreatic cell proliferation (GO:0044342) | 2.42969185 |
| 106 | endocardial cushion morphogenesis (GO:0003203) | 2.42341868 |
| 107 | negative regulation of hormone biosynthetic process (GO:0032353) | 2.42181168 |
| 108 | sarcomere organization (GO:0045214) | 2.41277240 |
| 109 | syncytium formation by plasma membrane fusion (GO:0000768) | 2.41059142 |
| 110 | glomerular epithelial cell development (GO:0072310) | 2.40957579 |
| 111 | wound healing, spreading of cells (GO:0044319) | 2.40850781 |
| 112 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 2.40778198 |
| 113 | peptidyl-proline hydroxylation (GO:0019511) | 2.40528928 |
| 114 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.40446552 |
| 115 | cell communication by electrical coupling (GO:0010644) | 2.39826663 |
| 116 | myelination in peripheral nervous system (GO:0022011) | 2.38245730 |
| 117 | peripheral nervous system axon ensheathment (GO:0032292) | 2.38245730 |
| 118 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 2.34934822 |
| 119 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.32848807 |
| 120 | adhesion of symbiont to host cell (GO:0044650) | 2.31999329 |
| 121 | virion attachment to host cell (GO:0019062) | 2.31999329 |
| 122 | cell migration involved in sprouting angiogenesis (GO:0002042) | 2.30952234 |
| 123 | protein hydroxylation (GO:0018126) | 2.30941871 |
| 124 | neuronal ion channel clustering (GO:0045161) | 2.30374708 |
| 125 | cell-substrate junction assembly (GO:0007044) | 2.26572803 |
| 126 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.26400127 |
| 127 | regulation of the force of heart contraction (GO:0002026) | 2.25316698 |
| 128 | actin filament depolymerization (GO:0030042) | 2.24606579 |
| 129 | adrenal gland development (GO:0030325) | 2.23635305 |
| 130 | heart trabecula formation (GO:0060347) | 2.23037411 |
| 131 | positive regulation of axon extension (GO:0045773) | 2.21081469 |
| 132 | trabecula formation (GO:0060343) | 2.21022624 |
| 133 | regulation of integrin-mediated signaling pathway (GO:2001044) | 2.19476189 |
| 134 | hemidesmosome assembly (GO:0031581) | 2.18755219 |
| 135 | detection of calcium ion (GO:0005513) | 2.17773413 |
| 136 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.16072857 |
| 137 | metanephric nephron tubule development (GO:0072234) | 2.15338005 |
| 138 | metanephric tubule development (GO:0072170) | 2.15338005 |
| 139 | atrial septum morphogenesis (GO:0060413) | 2.14899076 |
| 140 | cellular response to monoamine stimulus (GO:0071868) | 2.14713724 |
| 141 | cellular response to catecholamine stimulus (GO:0071870) | 2.14713724 |
| 142 | negative regulation of hormone metabolic process (GO:0032351) | 2.14100014 |
| 143 | regulation of cardioblast differentiation (GO:0051890) | 2.13403290 |
| 144 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.12794847 |
| 145 | actomyosin structure organization (GO:0031032) | 2.10335183 |
| 146 | regulation of axon guidance (GO:1902667) | 2.09172492 |
| 147 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.09057406 |
| 148 | cellular response to vitamin D (GO:0071305) | 2.08614918 |
| 149 | cellular potassium ion homeostasis (GO:0030007) | 2.07742886 |
| 150 | positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511) | 2.07399912 |
| 151 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 2.06976349 |
| 152 | glutamate secretion (GO:0014047) | 2.05902044 |
| 153 | neuron projection extension (GO:1990138) | 2.05336783 |
| 154 | axonal fasciculation (GO:0007413) | 2.04945875 |
| 155 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.04938866 |
| 156 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.04845914 |
| 157 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.04023219 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 5.59454398 |
| 2 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.48411095 |
| 3 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.08739373 |
| 4 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.81340860 |
| 5 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.73461701 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.45211324 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.45211324 |
| 8 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.38261223 |
| 9 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.34674339 |
| 10 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 2.33543066 |
| 11 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.26559501 |
| 12 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.19099519 |
| 13 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.18745097 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.18299209 |
| 15 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.16239974 |
| 16 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 2.16140286 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.14968220 |
| 18 | CJUN_26792858_Chip-Seq_BT549_Human | 2.14148768 |
| 19 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.01697342 |
| 20 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.01084231 |
| 21 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.00223660 |
| 22 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.98801326 |
| 23 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.95926870 |
| 24 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.94557990 |
| 25 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.94428628 |
| 26 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.92642639 |
| 27 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.91449000 |
| 28 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.88547474 |
| 29 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.85990909 |
| 30 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.85535035 |
| 31 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.82111726 |
| 32 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.74018753 |
| 33 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.72470870 |
| 34 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.69971654 |
| 35 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.69245656 |
| 36 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.63645046 |
| 37 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.61831071 |
| 38 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.52470744 |
| 39 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.48951173 |
| 40 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.48637300 |
| 41 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.45341032 |
| 42 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.44584250 |
| 43 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.44584250 |
| 44 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.43972031 |
| 45 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.43521161 |
| 46 | TP53_16413492_ChIP-PET_HCT116_Human | 1.43356678 |
| 47 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.42430482 |
| 48 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.42388604 |
| 49 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.42323087 |
| 50 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.41475276 |
| 51 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.40189806 |
| 52 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.38456770 |
| 53 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.37219622 |
| 54 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.30216482 |
| 55 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.29144057 |
| 56 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.28849221 |
| 57 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.27678355 |
| 58 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.27231164 |
| 59 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.26783208 |
| 60 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.26409439 |
| 61 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.25886937 |
| 62 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.25257655 |
| 63 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24873132 |
| 64 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.22074969 |
| 65 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.21806221 |
| 66 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.21520642 |
| 67 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.21247175 |
| 68 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.21139201 |
| 69 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.19739415 |
| 70 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.17113301 |
| 71 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.16739431 |
| 72 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.16257869 |
| 73 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.15721778 |
| 74 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.13461596 |
| 75 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.11792650 |
| 76 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.11251664 |
| 77 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.10107930 |
| 78 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.09355352 |
| 79 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.08946559 |
| 80 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.08648758 |
| 81 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.07503657 |
| 82 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.06966317 |
| 83 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06629162 |
| 84 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.06271566 |
| 85 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.05822255 |
| 86 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.04777006 |
| 87 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.04696538 |
| 88 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.04652024 |
| 89 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.04397844 |
| 90 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.04160602 |
| 91 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.03764364 |
| 92 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.03764364 |
| 93 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.02679246 |
| 94 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.02615093 |
| 95 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.00401811 |
| 96 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.00147237 |
| 97 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.00103497 |
| 98 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.99059429 |
| 99 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.99059429 |
| 100 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.97293027 |
| 101 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.96497641 |
| 102 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.96183724 |
| 103 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.96051512 |
| 104 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.95216962 |
| 105 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.94538579 |
| 106 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.94391506 |
| 107 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.94311476 |
| 108 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.94066151 |
| 109 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.93291930 |
| 110 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.93158753 |
| 111 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.93026600 |
| 112 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.92537841 |
| 113 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.92235521 |
| 114 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 0.91794972 |
| 115 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.91719061 |
| 116 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.91585350 |
| 117 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.90537651 |
| 118 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.90020196 |
| 119 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.89442181 |
| 120 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.88698670 |
| 121 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.87358984 |
| 122 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.84861257 |
| 123 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.83385112 |
| 124 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.82763490 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 6.92705143 |
| 2 | MP0005503_abnormal_tendon_morphology | 5.20644909 |
| 3 | MP0005275_abnormal_skin_tensile | 3.94087786 |
| 4 | MP0003279_aneurysm | 3.36405924 |
| 5 | MP0005623_abnormal_meninges_morphology | 3.17000303 |
| 6 | MP0010030_abnormal_orbit_morphology | 3.04037799 |
| 7 | MP0005257_abnormal_intraocular_pressure | 2.71335931 |
| 8 | MP0001958_emphysema | 2.70358094 |
| 9 | MP0004272_abnormal_basement_membrane | 2.69529400 |
| 10 | MP0009780_abnormal_chondrocyte_physiolo | 2.66107144 |
| 11 | MP0003705_abnormal_hypodermis_morpholog | 2.40862306 |
| 12 | MP0005508_abnormal_skeleton_morphology | 2.28479311 |
| 13 | MP0010368_abnormal_lymphatic_system | 2.19358235 |
| 14 | MP0003385_abnormal_body_wall | 1.98759794 |
| 15 | MP0002108_abnormal_muscle_morphology | 1.97474489 |
| 16 | MP0009250_abnormal_appendicular_skeleto | 1.96413733 |
| 17 | MP0001879_abnormal_lymphatic_vessel | 1.79382056 |
| 18 | MP0000049_abnormal_middle_ear | 1.71636074 |
| 19 | MP0000733_abnormal_muscle_development | 1.66838768 |
| 20 | MP0000751_myopathy | 1.65964266 |
| 21 | MP0009384_cardiac_valve_regurgitation | 1.57124220 |
| 22 | MP0000003_abnormal_adipose_tissue | 1.56898969 |
| 23 | MP0003942_abnormal_urinary_system | 1.55800887 |
| 24 | MP0003566_abnormal_cell_adhesion | 1.49564971 |
| 25 | MP0000767_abnormal_smooth_muscle | 1.44142744 |
| 26 | MP0002060_abnormal_skin_morphology | 1.43286879 |
| 27 | MP0000534_abnormal_ureter_morphology | 1.43071168 |
| 28 | MP0006054_spinal_hemorrhage | 1.42777378 |
| 29 | MP0003091_abnormal_cell_migration | 1.41101021 |
| 30 | MP0000749_muscle_degeneration | 1.39490238 |
| 31 | MP0002909_abnormal_adrenal_gland | 1.38310949 |
| 32 | MP0000428_abnormal_craniofacial_morphol | 1.37857716 |
| 33 | MP0003941_abnormal_skin_development | 1.36661659 |
| 34 | MP0002295_abnormal_pulmonary_circulatio | 1.33308432 |
| 35 | MP0004859_abnormal_synaptic_plasticity | 1.31852361 |
| 36 | MP0002249_abnormal_larynx_morphology | 1.31764258 |
| 37 | MP0001299_abnormal_eye_distance/ | 1.31592628 |
| 38 | MP0003755_abnormal_palate_morphology | 1.29993161 |
| 39 | MP0002697_abnormal_eye_size | 1.29772933 |
| 40 | MP0005367_renal/urinary_system_phenotyp | 1.28145234 |
| 41 | MP0000516_abnormal_urinary_system | 1.28145234 |
| 42 | MP0002932_abnormal_joint_morphology | 1.27385607 |
| 43 | MP0004134_abnormal_chest_morphology | 1.26755125 |
| 44 | MP0002896_abnormal_bone_mineralization | 1.24367134 |
| 45 | MP0010386_abnormal_urinary_bladder | 1.23263115 |
| 46 | MP0005171_absent_coat_pigmentation | 1.22909798 |
| 47 | MP0004036_abnormal_muscle_relaxation | 1.20049573 |
| 48 | MP0002877_abnormal_melanocyte_morpholog | 1.18715384 |
| 49 | MP0005197_abnormal_uvea_morphology | 1.18451680 |
| 50 | MP0008775_abnormal_heart_ventricle | 1.18232833 |
| 51 | MP0003283_abnormal_digestive_organ | 1.14214226 |
| 52 | MP0002089_abnormal_postnatal_growth/wei | 1.12663655 |
| 53 | MP0001542_abnormal_bone_strength | 1.12440144 |
| 54 | MP0000163_abnormal_cartilage_morphology | 1.12332043 |
| 55 | MP0003935_abnormal_craniofacial_develop | 1.12133084 |
| 56 | MP0000750_abnormal_muscle_regeneration | 1.11461335 |
| 57 | MP0004130_abnormal_muscle_cell | 1.11268325 |
| 58 | MP0004084_abnormal_cardiac_muscle | 1.11174956 |
| 59 | MP0002116_abnormal_craniofacial_bone | 1.10076619 |
| 60 | MP0005409_darkened_coat_color | 1.08971799 |
| 61 | MP0000462_abnormal_digestive_system | 1.06968547 |
| 62 | MP0009053_abnormal_anal_canal | 1.06029397 |
| 63 | MP0004215_abnormal_myocardial_fiber | 1.04723692 |
| 64 | MP0003115_abnormal_respiratory_system | 1.03873549 |
| 65 | MP0005390_skeleton_phenotype | 1.03201587 |
| 66 | MP0005620_abnormal_muscle_contractility | 1.02414036 |
| 67 | MP0000759_abnormal_skeletal_muscle | 1.02259424 |
| 68 | MP0000762_abnormal_tongue_morphology | 1.02146400 |
| 69 | MP0003045_fibrosis | 0.99664275 |
| 70 | MP0002938_white_spotting | 0.98262051 |
| 71 | MP0002282_abnormal_trachea_morphology | 0.97548839 |
| 72 | MP0002233_abnormal_nose_morphology | 0.97361825 |
| 73 | MP0005330_cardiomyopathy | 0.96972310 |
| 74 | MP0002115_abnormal_skeleton_extremities | 0.95114762 |
| 75 | MP0005248_abnormal_Harderian_gland | 0.94925497 |
| 76 | MP0005551_abnormal_eye_electrophysiolog | 0.93044385 |
| 77 | MP0006072_abnormal_retinal_apoptosis | 0.92473312 |
| 78 | MP0005670_abnormal_white_adipose | 0.92145579 |
| 79 | MP0002972_abnormal_cardiac_muscle | 0.92138423 |
| 80 | MP0003011_delayed_dark_adaptation | 0.91565311 |
| 81 | MP0005193_abnormal_anterior_eye | 0.91420642 |
| 82 | MP0002168_other_aberrant_phenotype | 0.90412676 |
| 83 | MP0004085_abnormal_heartbeat | 0.88929265 |
| 84 | MP0001661_extended_life_span | 0.88853507 |
| 85 | MP0002837_dystrophic_cardiac_calcinosis | 0.88475220 |
| 86 | MP0003937_abnormal_limbs/digits/tail_de | 0.88390319 |
| 87 | MP0005369_muscle_phenotype | 0.88039724 |
| 88 | MP0003123_paternal_imprinting | 0.87606806 |
| 89 | MP0002234_abnormal_pharynx_morphology | 0.87587751 |
| 90 | MP0005595_abnormal_vascular_smooth | 0.87316202 |
| 91 | MP0005023_abnormal_wound_healing | 0.87137768 |
| 92 | MP0001177_atelectasis | 0.86859985 |
| 93 | MP0003879_abnormal_hair_cell | 0.86181493 |
| 94 | MP0002128_abnormal_blood_circulation | 0.85921700 |
| 95 | MP0003329_amyloid_beta_deposits | 0.85795463 |
| 96 | MP0002109_abnormal_limb_morphology | 0.84866119 |
| 97 | MP0000678_abnormal_parathyroid_gland | 0.84377851 |
| 98 | MP0000432_abnormal_head_morphology | 0.84133814 |
| 99 | MP0002113_abnormal_skeleton_development | 0.83929259 |
| 100 | MP0003122_maternal_imprinting | 0.82723591 |
| 101 | MP0005375_adipose_tissue_phenotype | 0.82376288 |
| 102 | MP0000013_abnormal_adipose_tissue | 0.81827771 |
| 103 | MP0002177_abnormal_outer_ear | 0.81743990 |
| 104 | MP0002114_abnormal_axial_skeleton | 0.79348451 |
| 105 | MP0002933_joint_inflammation | 0.78249215 |
| 106 | MP0001614_abnormal_blood_vessel | 0.78076639 |
| 107 | MP0001286_abnormal_eye_development | 0.77644955 |
| 108 | MP0004087_abnormal_muscle_fiber | 0.77519184 |
| 109 | MP0006292_abnormal_olfactory_placode | 0.77319953 |
| 110 | MP0006138_congestive_heart_failure | 0.76840332 |
| 111 | MP0003950_abnormal_plasma_membrane | 0.76633537 |
| 112 | MP0004270_analgesia | 0.76511990 |
| 113 | MP0000537_abnormal_urethra_morphology | 0.75826649 |
| 114 | MP0001175_abnormal_lung_morphology | 0.74445355 |
| 115 | MP0005253_abnormal_eye_physiology | 0.74328383 |
| 116 | MP0000681_abnormal_thyroid_gland | 0.74227403 |
| 117 | MP0002925_abnormal_cardiovascular_devel | 0.74206239 |
| 118 | MP0002269_muscular_atrophy | 0.74055899 |
| 119 | MP0004233_abnormal_muscle_weight | 0.73495731 |
| 120 | MP0010630_abnormal_cardiac_muscle | 0.73479210 |
| 121 | MP0004858_abnormal_nervous_system | 0.72160051 |
| 122 | MP0002876_abnormal_thyroid_physiology | 0.71840462 |
| 123 | MP0005391_vision/eye_phenotype | 0.71784482 |
| 124 | MP0002106_abnormal_muscle_physiology | 0.71770889 |
| 125 | MP0004885_abnormal_endolymph | 0.71699490 |
| 126 | MP0000778_abnormal_nervous_system | 0.71316570 |
| 127 | MP0001348_abnormal_lacrimal_gland | 0.69920091 |
| 128 | MP0000747_muscle_weakness | 0.69496443 |
| 129 | MP0003137_abnormal_impulse_conducting | 0.68924079 |
| 130 | MP0002184_abnormal_innervation | 0.65615939 |
| 131 | MP0000639_abnormal_adrenal_gland | 0.65017772 |
| 132 | MP0001502_abnormal_circadian_rhythm | 0.64157405 |
| 133 | MP0003959_abnormal_lean_body | 0.64103754 |
| 134 | MP0005385_cardiovascular_system_phenoty | 0.63376961 |
| 135 | MP0001544_abnormal_cardiovascular_syste | 0.63376961 |
| 136 | MP0001270_distended_abdomen | 0.63076561 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 7.29235478 |
| 2 | Premature rupture of membranes (HP:0001788) | 7.17219445 |
| 3 | Shallow orbits (HP:0000586) | 4.39628443 |
| 4 | Aortic dissection (HP:0002647) | 4.20375106 |
| 5 | Abnormality of dentin (HP:0010299) | 4.04003030 |
| 6 | Broad metatarsal (HP:0001783) | 3.99290698 |
| 7 | Bladder diverticulum (HP:0000015) | 3.97667085 |
| 8 | Soft skin (HP:0000977) | 3.91682466 |
| 9 | Ankle contracture (HP:0006466) | 3.84773400 |
| 10 | Atrophic scars (HP:0001075) | 3.72037640 |
| 11 | Type 1 muscle fiber predominance (HP:0003803) | 3.45663377 |
| 12 | Spinal rigidity (HP:0003306) | 3.45366502 |
| 13 | Follicular hyperkeratosis (HP:0007502) | 3.39667493 |
| 14 | Fragile skin (HP:0001030) | 3.36946257 |
| 15 | Neonatal short-limb short stature (HP:0008921) | 3.32368203 |
| 16 | Cerebral aneurysm (HP:0004944) | 3.27576669 |
| 17 | Wrist flexion contracture (HP:0001239) | 3.10242561 |
| 18 | Increased connective tissue (HP:0009025) | 3.08683881 |
| 19 | Peritonitis (HP:0002586) | 2.97385858 |
| 20 | Aortic aneurysm (HP:0004942) | 2.97237753 |
| 21 | Vertebral compression fractures (HP:0002953) | 2.95049038 |
| 22 | Dilatation of the ascending aorta (HP:0005111) | 2.86979027 |
| 23 | Wormian bones (HP:0002645) | 2.80742668 |
| 24 | Bowel diverticulosis (HP:0005222) | 2.77152669 |
| 25 | Genu recurvatum (HP:0002816) | 2.75808943 |
| 26 | Overgrowth (HP:0001548) | 2.73439205 |
| 27 | Nuclear cataract (HP:0100018) | 2.70164572 |
| 28 | Blue sclerae (HP:0000592) | 2.69093439 |
| 29 | Mitral stenosis (HP:0001718) | 2.65444445 |
| 30 | Biconcave vertebral bodies (HP:0004586) | 2.64548829 |
| 31 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.64456319 |
| 32 | Cervical subluxation (HP:0003308) | 2.61878613 |
| 33 | Keratoconus (HP:0000563) | 2.53896399 |
| 34 | Increased corneal curvature (HP:0100692) | 2.53896399 |
| 35 | Mitral valve prolapse (HP:0001634) | 2.50167112 |
| 36 | Cardiovascular calcification (HP:0011915) | 2.46700835 |
| 37 | Spinal cord lesions (HP:0100561) | 2.37637622 |
| 38 | Syringomyelia (HP:0003396) | 2.37637622 |
| 39 | Hyperextensible skin (HP:0000974) | 2.30840436 |
| 40 | Atrial fibrillation (HP:0005110) | 2.30425019 |
| 41 | Joint laxity (HP:0001388) | 2.28819742 |
| 42 | Bundle branch block (HP:0011710) | 2.28114348 |
| 43 | Congenital stationary night blindness (HP:0007642) | 2.27612943 |
| 44 | Increased variability in muscle fiber diameter (HP:0003557) | 2.26716943 |
| 45 | Flat cornea (HP:0007720) | 2.25320626 |
| 46 | Vascular tortuosity (HP:0004948) | 2.24809689 |
| 47 | Abnormal delivery (HP:0001787) | 2.22282586 |
| 48 | Bradycardia (HP:0001662) | 2.21684494 |
| 49 | Bell-shaped thorax (HP:0001591) | 2.17702130 |
| 50 | Morphological abnormality of the middle ear (HP:0008609) | 2.14229249 |
| 51 | Asymmetry of the thorax (HP:0001555) | 2.13921330 |
| 52 | Thin ribs (HP:0000883) | 2.12996805 |
| 53 | Infantile muscular hypotonia (HP:0008947) | 2.12593762 |
| 54 | Round ear (HP:0100830) | 2.12038096 |
| 55 | Camptodactyly of toe (HP:0001836) | 2.10120200 |
| 56 | Aortic regurgitation (HP:0001659) | 2.09687339 |
| 57 | Wide anterior fontanel (HP:0000260) | 2.09381967 |
| 58 | Pulmonary artery stenosis (HP:0004415) | 2.09031257 |
| 59 | Scapular winging (HP:0003691) | 2.07302545 |
| 60 | Elbow flexion contracture (HP:0002987) | 2.07096398 |
| 61 | Zonular cataract (HP:0010920) | 2.06963668 |
| 62 | Deviation of the hallux (HP:0010051) | 2.06582010 |
| 63 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.06558494 |
| 64 | Primary atrial arrhythmia (HP:0001692) | 2.05000446 |
| 65 | Breech presentation (HP:0001623) | 2.04301863 |
| 66 | Coronal craniosynostosis (HP:0004440) | 2.02590587 |
| 67 | Ulnar bowing (HP:0003031) | 2.02145329 |
| 68 | Supraventricular arrhythmia (HP:0005115) | 2.01870615 |
| 69 | Supraventricular tachycardia (HP:0004755) | 1.98229971 |
| 70 | Striae distensae (HP:0001065) | 1.97590327 |
| 71 | Distal lower limb amyotrophy (HP:0008944) | 1.94646431 |
| 72 | Hallux valgus (HP:0001822) | 1.93406504 |
| 73 | Narrow nasal bridge (HP:0000446) | 1.91687663 |
| 74 | Aneurysm (HP:0002617) | 1.90664097 |
| 75 | Slender build (HP:0001533) | 1.90050332 |
| 76 | Osteoarthritis (HP:0002758) | 1.89961069 |
| 77 | Sudden death (HP:0001699) | 1.89146678 |
| 78 | Joint stiffness (HP:0001387) | 1.85707135 |
| 79 | Chorioretinal atrophy (HP:0000533) | 1.85363915 |
| 80 | Mitral regurgitation (HP:0001653) | 1.85133671 |
| 81 | Ectopia lentis (HP:0001083) | 1.84769061 |
| 82 | Broad ribs (HP:0000885) | 1.84255529 |
| 83 | Aortic valve stenosis (HP:0001650) | 1.84184423 |
| 84 | Vascular calcification (HP:0004934) | 1.83373695 |
| 85 | Venous abnormality (HP:0002624) | 1.83244229 |
| 86 | Asymmetric septal hypertrophy (HP:0001670) | 1.83090323 |
| 87 | Hypoventilation (HP:0002791) | 1.82830430 |
| 88 | Alopecia of scalp (HP:0002293) | 1.82756695 |
| 89 | Hip contracture (HP:0003273) | 1.82473469 |
| 90 | Coxa vara (HP:0002812) | 1.81608631 |
| 91 | Knee flexion contracture (HP:0006380) | 1.81444453 |
| 92 | Buphthalmos (HP:0000557) | 1.81159166 |
| 93 | Lipoatrophy (HP:0100578) | 1.80963853 |
| 94 | Spondylolisthesis (HP:0003302) | 1.80666019 |
| 95 | Enlarged penis (HP:0000040) | 1.80646765 |
| 96 | Ventricular tachycardia (HP:0004756) | 1.80624772 |
| 97 | Long toe (HP:0010511) | 1.80110375 |
| 98 | Short nail (HP:0001799) | 1.79824130 |
| 99 | Abnormality of the calf musculature (HP:0001430) | 1.78841211 |
| 100 | Thin bony cortex (HP:0002753) | 1.77458488 |
| 101 | Ovoid vertebral bodies (HP:0003300) | 1.77437833 |
| 102 | Venous insufficiency (HP:0005293) | 1.77375851 |
| 103 | Protruding ear (HP:0000411) | 1.77026457 |
| 104 | Difficulty climbing stairs (HP:0003551) | 1.76099469 |
| 105 | Renal duplication (HP:0000075) | 1.75705609 |
| 106 | Arterial tortuosity (HP:0005116) | 1.75222864 |
| 107 | Mild short stature (HP:0003502) | 1.75020874 |
| 108 | Osteopenia (HP:0000938) | 1.74924379 |
| 109 | Joint contractures involving the joints of the feet (HP:0100492) | 1.74305971 |
| 110 | Flexion contracture of toe (HP:0005830) | 1.74305971 |
| 111 | Inguinal hernia (HP:0000023) | 1.70146570 |
| 112 | Corneal dystrophy (HP:0001131) | 1.69994942 |
| 113 | Mesomelia (HP:0003027) | 1.68380679 |
| 114 | Congenital glaucoma (HP:0001087) | 1.68118779 |
| 115 | Abnormality of the acetabulum (HP:0003170) | 1.67629424 |
| 116 | Turricephaly (HP:0000262) | 1.66684395 |
| 117 | Redundant skin (HP:0001582) | 1.66279762 |
| 118 | Aplasia of the phalanges of the hand (HP:0009802) | 1.65786944 |
| 119 | Aplasia involving bones of the extremities (HP:0009825) | 1.65786944 |
| 120 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.65786944 |
| 121 | Popliteal pterygium (HP:0009756) | 1.65783209 |
| 122 | Hypoplasia of the iris (HP:0007676) | 1.65161767 |
| 123 | Broad long bones (HP:0005622) | 1.64519032 |
| 124 | Distal upper limb amyotrophy (HP:0007149) | 1.63113732 |
| 125 | Upper limb amyotrophy (HP:0009129) | 1.63113732 |
| 126 | Pterygium (HP:0001059) | 1.62649669 |
| 127 | Hyporeflexia of lower limbs (HP:0002600) | 1.61755260 |
| 128 | Scotoma (HP:0000575) | 1.61700414 |
| 129 | Limited hip movement (HP:0008800) | 1.61190081 |
| 130 | Thoracolumbar scoliosis (HP:0002944) | 1.60048029 |
| 131 | Abnormal atrioventricular conduction (HP:0005150) | 1.59981697 |
| 132 | Disproportionate tall stature (HP:0001519) | 1.59119606 |
| 133 | Bowed forearm bones (HP:0003956) | 1.57312287 |
| 134 | Bowing of the arm (HP:0006488) | 1.57312287 |
| 135 | Prolonged QT interval (HP:0001657) | 1.57011329 |
| 136 | Spinal cord compression (HP:0002176) | 1.56259871 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHB2 | 3.95061366 |
| 2 | LATS1 | 3.90952499 |
| 3 | DDR2 | 3.74997797 |
| 4 | PDGFRA | 3.28517514 |
| 5 | LATS2 | 3.22391948 |
| 6 | TRIB3 | 3.12668723 |
| 7 | TTN | 2.86925082 |
| 8 | STK38L | 2.48325307 |
| 9 | PKN2 | 2.26446243 |
| 10 | TIE1 | 2.02145737 |
| 11 | SIK1 | 2.01567690 |
| 12 | NTRK3 | 1.84787673 |
| 13 | FER | 1.72842215 |
| 14 | PAK2 | 1.68621462 |
| 15 | BMX | 1.61708271 |
| 16 | TGFBR2 | 1.60169672 |
| 17 | PRPF4B | 1.54796970 |
| 18 | TESK1 | 1.53752532 |
| 19 | EPHA3 | 1.53082772 |
| 20 | DMPK | 1.51706536 |
| 21 | ROCK1 | 1.50275051 |
| 22 | MAP3K9 | 1.49975387 |
| 23 | NEK9 | 1.49331492 |
| 24 | ICK | 1.46571922 |
| 25 | MYLK | 1.44960919 |
| 26 | RIPK1 | 1.34821711 |
| 27 | MOS | 1.31622012 |
| 28 | PTK2 | 1.30698608 |
| 29 | TRPM7 | 1.29562019 |
| 30 | WNK4 | 1.27736435 |
| 31 | PAK3 | 1.27402362 |
| 32 | PAK4 | 1.22803350 |
| 33 | PRKD2 | 1.22211395 |
| 34 | MUSK | 1.21286497 |
| 35 | WNK1 | 1.18818490 |
| 36 | ERBB3 | 1.18148523 |
| 37 | PIM2 | 1.17185397 |
| 38 | ILK | 1.13444699 |
| 39 | ARAF | 1.10621046 |
| 40 | ZAK | 1.09491355 |
| 41 | INSRR | 1.08975912 |
| 42 | GRK1 | 1.07759913 |
| 43 | TGFBR1 | 1.05534729 |
| 44 | CDK8 | 1.04374502 |
| 45 | STK3 | 1.02839352 |
| 46 | TAOK2 | 1.02435021 |
| 47 | PTK2B | 1.02128734 |
| 48 | MKNK2 | 1.01659060 |
| 49 | BMPR1B | 1.00384512 |
| 50 | DYRK1B | 1.00350147 |
| 51 | PDGFRB | 0.97998131 |
| 52 | LMTK2 | 0.95017307 |
| 53 | NUAK1 | 0.94357207 |
| 54 | PLK2 | 0.92311946 |
| 55 | EEF2K | 0.92079431 |
| 56 | ROCK2 | 0.91744257 |
| 57 | ERN1 | 0.90822071 |
| 58 | ADRBK1 | 0.90726985 |
| 59 | ABL2 | 0.90568688 |
| 60 | PRKCE | 0.89602836 |
| 61 | CASK | 0.88598043 |
| 62 | ERBB4 | 0.83800419 |
| 63 | PRKD1 | 0.83245131 |
| 64 | PIK3CA | 0.82627485 |
| 65 | NTRK2 | 0.82579395 |
| 66 | TYRO3 | 0.82103261 |
| 67 | FGFR1 | 0.81410096 |
| 68 | PTK6 | 0.81408416 |
| 69 | CAMK1 | 0.80517013 |
| 70 | PAK6 | 0.79807796 |
| 71 | MAP3K6 | 0.78503434 |
| 72 | MKNK1 | 0.78209755 |
| 73 | LIMK1 | 0.76073352 |
| 74 | AKT3 | 0.73700381 |
| 75 | SGK494 | 0.73292270 |
| 76 | SGK223 | 0.73292270 |
| 77 | PNCK | 0.72933973 |
| 78 | CAMK2D | 0.71039450 |
| 79 | PHKG2 | 0.70520146 |
| 80 | PHKG1 | 0.70520146 |
| 81 | EPHB1 | 0.70032477 |
| 82 | STK38 | 0.68465986 |
| 83 | FGFR4 | 0.67465664 |
| 84 | MAP3K7 | 0.65652869 |
| 85 | MTOR | 0.65625486 |
| 86 | MAPKAPK3 | 0.65506932 |
| 87 | CDC42BPA | 0.64687131 |
| 88 | DAPK3 | 0.63504423 |
| 89 | MET | 0.63286313 |
| 90 | PRKCH | 0.63216463 |
| 91 | SIK3 | 0.62983461 |
| 92 | EPHA4 | 0.61885997 |
| 93 | KSR2 | 0.61813361 |
| 94 | NTRK1 | 0.61573158 |
| 95 | RPS6KA2 | 0.61418221 |
| 96 | PRKD3 | 0.60566848 |
| 97 | CAMK1G | 0.59946659 |
| 98 | RET | 0.58957372 |
| 99 | SGK3 | 0.58105833 |
| 100 | FGFR2 | 0.57733248 |
| 101 | CAMK2G | 0.56979205 |
| 102 | PRKAA1 | 0.56015715 |
| 103 | RPS6KA4 | 0.54668605 |
| 104 | TLK1 | 0.54615771 |
| 105 | ERBB2 | 0.53518794 |
| 106 | GRK5 | 0.53361356 |
| 107 | MARK2 | 0.53186475 |
| 108 | FLT3 | 0.52872244 |
| 109 | MAP3K10 | 0.52314911 |
| 110 | CDK5 | 0.52206562 |
| 111 | BRD4 | 0.52147876 |
| 112 | DAPK2 | 0.52038917 |
| 113 | MAP2K1 | 0.51549981 |
| 114 | PDPK1 | 0.51490773 |
| 115 | INSR | 0.51109650 |
| 116 | CAMK2B | 0.50918821 |
| 117 | PRKCG | 0.49264776 |
| 118 | PINK1 | 0.48722088 |
| 119 | MAP3K2 | 0.47826005 |
| 120 | EPHA2 | 0.45697170 |
| 121 | CHUK | 0.45182093 |
| 122 | CAMK2A | 0.44531075 |
| 123 | UHMK1 | 0.44467443 |
| 124 | DYRK2 | 0.43308199 |
| 125 | FGFR3 | 0.42213558 |
| 126 | STK24 | 0.40558445 |
| 127 | MAPK12 | 0.39785550 |
| 128 | CDK9 | 0.38896848 |
| 129 | MARK1 | 0.35668005 |
| 130 | AKT1 | 0.35443817 |
| 131 | SRC | 0.34609383 |
| 132 | FRK | 0.34262859 |
| 133 | RPS6KL1 | 0.33922681 |
| 134 | RPS6KC1 | 0.33922681 |
| 135 | PIK3CG | 0.31615266 |
| 136 | PRKG2 | 0.31365993 |
| 137 | MAPK1 | 0.29695941 |
| 138 | RPS6KA6 | 0.29310334 |
| 139 | GSK3A | 0.28922672 |
| 140 | MARK3 | 0.27458852 |
| 141 | AKT2 | 0.26605214 |
| 142 | MAPK13 | 0.26572940 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 3.37818908 |
| 2 | Focal adhesion_Homo sapiens_hsa04510 | 2.48026275 |
| 3 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.44902292 |
| 4 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.44582882 |
| 5 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.43489512 |
| 6 | Phototransduction_Homo sapiens_hsa04744 | 2.26750021 |
| 7 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 2.00964431 |
| 8 | Melanoma_Homo sapiens_hsa05218 | 1.84498182 |
| 9 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.83523169 |
| 10 | Amoebiasis_Homo sapiens_hsa05146 | 1.81456480 |
| 11 | Adherens junction_Homo sapiens_hsa04520 | 1.80089655 |
| 12 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.79788496 |
| 13 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.79772598 |
| 14 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.76158268 |
| 15 | Axon guidance_Homo sapiens_hsa04360 | 1.71297547 |
| 16 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.67875922 |
| 17 | Bladder cancer_Homo sapiens_hsa05219 | 1.67179732 |
| 18 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.66085670 |
| 19 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.65689550 |
| 20 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.55633316 |
| 21 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.52475724 |
| 22 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.50704098 |
| 23 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.47571659 |
| 24 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.44266514 |
| 25 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.36720323 |
| 26 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.34511107 |
| 27 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.30438622 |
| 28 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.28475343 |
| 29 | Malaria_Homo sapiens_hsa05144 | 1.27121674 |
| 30 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.24484699 |
| 31 | Glioma_Homo sapiens_hsa05214 | 1.24288227 |
| 32 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.23109521 |
| 33 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.20703885 |
| 34 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.19750040 |
| 35 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.18666950 |
| 36 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.17414419 |
| 37 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.15787007 |
| 38 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.15322970 |
| 39 | Viral myocarditis_Homo sapiens_hsa05416 | 1.14435126 |
| 40 | Prostate cancer_Homo sapiens_hsa05215 | 1.13161580 |
| 41 | Pathways in cancer_Homo sapiens_hsa05200 | 1.12174989 |
| 42 | Melanogenesis_Homo sapiens_hsa04916 | 1.07139691 |
| 43 | Tight junction_Homo sapiens_hsa04530 | 1.07099634 |
| 44 | Ras signaling pathway_Homo sapiens_hsa04014 | 1.01511173 |
| 45 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.01367908 |
| 46 | Prion diseases_Homo sapiens_hsa05020 | 1.00857735 |
| 47 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.00828315 |
| 48 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.00638309 |
| 49 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.96929223 |
| 50 | Endometrial cancer_Homo sapiens_hsa05213 | 0.96695443 |
| 51 | GABAergic synapse_Homo sapiens_hsa04727 | 0.95267858 |
| 52 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.94325781 |
| 53 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.93875373 |
| 54 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.91497734 |
| 55 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.90422682 |
| 56 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.89354389 |
| 57 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.89152938 |
| 58 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.87062383 |
| 59 | Gap junction_Homo sapiens_hsa04540 | 0.86767958 |
| 60 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.86423971 |
| 61 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.84461213 |
| 62 | Bile secretion_Homo sapiens_hsa04976 | 0.83345030 |
| 63 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.83269678 |
| 64 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.81369546 |
| 65 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.81209095 |
| 66 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.80401980 |
| 67 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.80244383 |
| 68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.79836156 |
| 69 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.79124305 |
| 70 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.78559660 |
| 71 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.78105590 |
| 72 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.77647388 |
| 73 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.77025092 |
| 74 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.77003680 |
| 75 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.76723480 |
| 76 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.76270598 |
| 77 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.74690243 |
| 78 | Colorectal cancer_Homo sapiens_hsa05210 | 0.74441687 |
| 79 | Platelet activation_Homo sapiens_hsa04611 | 0.74254296 |
| 80 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.73023931 |
| 81 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.72377434 |
| 82 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.71978716 |
| 83 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.71082786 |
| 84 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.70893643 |
| 85 | Long-term potentiation_Homo sapiens_hsa04720 | 0.70523819 |
| 86 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.70301770 |
| 87 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.70285572 |
| 88 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.69663483 |
| 89 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.69041636 |
| 90 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.68844316 |
| 91 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.68715847 |
| 92 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.68711019 |
| 93 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.67841204 |
| 94 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.67809880 |
| 95 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.67352984 |
| 96 | Renin secretion_Homo sapiens_hsa04924 | 0.66942580 |
| 97 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.66475261 |
| 98 | Phagosome_Homo sapiens_hsa04145 | 0.65870514 |
| 99 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.64138499 |
| 100 | Circadian entrainment_Homo sapiens_hsa04713 | 0.64001873 |
| 101 | Circadian rhythm_Homo sapiens_hsa04710 | 0.63521608 |
| 102 | Salivary secretion_Homo sapiens_hsa04970 | 0.62832385 |
| 103 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.62800313 |
| 104 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.62394395 |
| 105 | Insulin secretion_Homo sapiens_hsa04911 | 0.61802047 |
| 106 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.61572043 |
| 107 | Salmonella infection_Homo sapiens_hsa05132 | 0.61429643 |
| 108 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.60298168 |
| 109 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.59390996 |
| 110 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.59032618 |
| 111 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.58806902 |
| 112 | Cocaine addiction_Homo sapiens_hsa05030 | 0.57384496 |
| 113 | Taste transduction_Homo sapiens_hsa04742 | 0.55579294 |
| 114 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.54848250 |
| 115 | Long-term depression_Homo sapiens_hsa04730 | 0.54426807 |
| 116 | Morphine addiction_Homo sapiens_hsa05032 | 0.53040465 |
| 117 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.52611754 |
| 118 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.51911179 |
| 119 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.50910653 |
| 120 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.50901617 |
| 121 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.48883834 |
| 122 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.47400287 |
| 123 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47047878 |
| 124 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.46702016 |
| 125 | Insulin resistance_Homo sapiens_hsa04931 | 0.46686127 |
| 126 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.45740957 |
| 127 | Nicotine addiction_Homo sapiens_hsa05033 | 0.45097311 |
| 128 | Olfactory transduction_Homo sapiens_hsa04740 | 0.45028672 |
| 129 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.44931836 |
| 130 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.44915383 |
| 131 | Apoptosis_Homo sapiens_hsa04210 | 0.44675025 |
| 132 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.43524317 |
| 133 | Hepatitis B_Homo sapiens_hsa05161 | 0.43234488 |

