MXRA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.88553026
2collagen fibril organization (GO:0030199)6.09459720
3sequestering of extracellular ligand from receptor (GO:0035581)5.15221791
4chondrocyte proliferation (GO:0035988)5.14477486
5bone trabecula formation (GO:0060346)5.04809256
6type B pancreatic cell proliferation (GO:0044342)4.78026338
7endodermal cell differentiation (GO:0035987)4.57731178
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.54035685
9collagen metabolic process (GO:0032963)4.44504143
10collagen catabolic process (GO:0030574)4.37348809
11neuron projection extension involved in neuron projection guidance (GO:1902284)4.35253961
12axon extension involved in axon guidance (GO:0048846)4.35253961
13extracellular fibril organization (GO:0043206)4.29392643
14adhesion of symbiont to host (GO:0044406)4.28269624
15basement membrane organization (GO:0071711)4.27325043
16multicellular organismal macromolecule metabolic process (GO:0044259)4.23088059
17blood vessel maturation (GO:0001955)4.20185038
18multicellular organismal catabolic process (GO:0044243)4.08556335
19keratan sulfate catabolic process (GO:0042340)4.05794145
20skin morphogenesis (GO:0043589)4.04359920
21multicellular organismal metabolic process (GO:0044236)4.01284067
22retina vasculature morphogenesis in camera-type eye (GO:0061299)4.01208853
23vascular endothelial growth factor signaling pathway (GO:0038084)3.99594789
24dermatan sulfate biosynthetic process (GO:0030208)3.99027984
25tooth mineralization (GO:0034505)3.94937923
26glomerular basement membrane development (GO:0032836)3.89150075
27fibril organization (GO:0097435)3.87370143
28extracellular matrix disassembly (GO:0022617)3.82982675
29cell adhesion mediated by integrin (GO:0033627)3.77033518
30peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.72671683
31extracellular matrix assembly (GO:0085029)3.69172389
32dermatan sulfate metabolic process (GO:0030205)3.61848201
33barbed-end actin filament capping (GO:0051016)3.60613759
34cell migration involved in heart development (GO:0060973)3.60566334
35wound healing, spreading of epidermal cells (GO:0035313)3.59418706
36positive regulation of endothelial cell apoptotic process (GO:2000353)3.58679866
37regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.56431887
38plasma membrane repair (GO:0001778)3.49711458
39metanephric mesenchyme development (GO:0072075)3.49505440
40mesenchymal-epithelial cell signaling (GO:0060638)3.48825773
41apoptotic cell clearance (GO:0043277)3.48039754
42endothelial cell morphogenesis (GO:0001886)3.43152208
43cellular response to vitamin (GO:0071295)3.40956303
44lymphangiogenesis (GO:0001946)3.35257555
45endocardial cushion development (GO:0003197)3.35235238
46epithelial cell-cell adhesion (GO:0090136)3.29478506
47negative regulation of chondrocyte differentiation (GO:0032331)3.26854981
48kidney mesenchyme development (GO:0072074)3.24805942
49peptidyl-proline hydroxylation (GO:0019511)3.23679544
50regulation of extracellular matrix disassembly (GO:0010715)3.20456426
51extracellular matrix organization (GO:0030198)3.20136976
52extracellular structure organization (GO:0043062)3.18872068
53cell-substrate junction assembly (GO:0007044)3.17878314
54glomerular filtration (GO:0003094)3.17337998
55negative regulation of fatty acid transport (GO:2000192)3.16446081
56renal filtration (GO:0097205)3.16043789
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.15363625
58craniofacial suture morphogenesis (GO:0097094)3.08224584
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.05272580
60venous blood vessel morphogenesis (GO:0048845)3.00743974
61negative regulation of osteoblast proliferation (GO:0033689)3.00043489
62endothelial cell proliferation (GO:0001935)2.98542510
63regulation of plasminogen activation (GO:0010755)2.96053911
64positive regulation of epithelial to mesenchymal transition (GO:0010718)2.96022191
65atrioventricular valve morphogenesis (GO:0003181)2.95376602
66negative regulation of BMP signaling pathway (GO:0030514)2.94454744
67regulation of tight junction assembly (GO:2000810)2.94441079
68cochlea morphogenesis (GO:0090103)2.93139266
69adherens junction assembly (GO:0034333)2.92248233
70cell migration involved in sprouting angiogenesis (GO:0002042)2.91251372
71stress fiber assembly (GO:0043149)2.91227112
72trabecula formation (GO:0060343)2.90784780
73protein localization to cell surface (GO:0034394)2.90170667
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89833079
75cellular response to vitamin D (GO:0071305)2.89687575
76protein hydroxylation (GO:0018126)2.88799206
77negative regulation of catenin import into nucleus (GO:0035414)2.87890502
78planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86624902
79substrate adhesion-dependent cell spreading (GO:0034446)2.86163297
80wound healing, spreading of cells (GO:0044319)2.85466746
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82600721
82positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81830346
83smooth muscle tissue development (GO:0048745)2.80731428
84negative regulation of cartilage development (GO:0061037)2.80227148
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79635794
86hippo signaling (GO:0035329)2.77942262
87positive regulation of cartilage development (GO:0061036)2.76770112
88positive regulation of osteoblast proliferation (GO:0033690)2.76461534
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75639421
90cell-substrate adherens junction assembly (GO:0007045)2.75589118
91focal adhesion assembly (GO:0048041)2.75589118
92regulation of establishment of planar polarity (GO:0090175)2.75267555
93glomerular visceral epithelial cell development (GO:0072015)2.75097523
94adhesion of symbiont to host cell (GO:0044650)2.74557357
95virion attachment to host cell (GO:0019062)2.74557357
96protein retention in ER lumen (GO:0006621)2.73232870
97positive regulation of blood vessel endothelial cell migration (GO:0043536)2.72605897
98branching involved in salivary gland morphogenesis (GO:0060445)2.72571426
99negative regulation of leukocyte chemotaxis (GO:0002689)2.72344850
100extracellular negative regulation of signal transduction (GO:1900116)2.72041762
101extracellular regulation of signal transduction (GO:1900115)2.72041762
102heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.71524479
103muscle cell migration (GO:0014812)2.71116968
104lymph vessel development (GO:0001945)2.70908679
105negative regulation of smooth muscle cell migration (GO:0014912)2.70330056
106chondroitin sulfate catabolic process (GO:0030207)2.70157791
107cellular response to interferon-alpha (GO:0035457)2.70101521
108substrate-dependent cell migration (GO:0006929)2.68396806
109middle ear morphogenesis (GO:0042474)2.66386823
110regulation of integrin-mediated signaling pathway (GO:2001044)2.65993800
111Golgi transport vesicle coating (GO:0048200)2.65491655
112COPI coating of Golgi vesicle (GO:0048205)2.65491655
113cell proliferation involved in metanephros development (GO:0072203)2.64239218
114negative regulation of cardiac muscle tissue growth (GO:0055022)2.64040396
115negative regulation of heart growth (GO:0061117)2.64040396
116regulation of endothelial cell differentiation (GO:0045601)2.63620098
117positive regulation of glycogen biosynthetic process (GO:0045725)2.62221997
118cellular response to amino acid stimulus (GO:0071230)2.62025068
119cell-matrix adhesion (GO:0007160)2.61687622
120outer ear morphogenesis (GO:0042473)2.61435682
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.61413287
122positive regulation of extracellular matrix organization (GO:1903055)2.60649830
123lung lobe morphogenesis (GO:0060463)2.60616495
124chondroitin sulfate biosynthetic process (GO:0030206)2.60310145
125regulation of SMAD protein import into nucleus (GO:0060390)2.59697842
126regulation of smooth muscle cell migration (GO:0014910)2.58888486
127regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58823852
128regulation of osteoblast proliferation (GO:0033688)2.58332381
129positive regulation of axon extension (GO:0045773)2.58155473
130hemidesmosome assembly (GO:0031581)2.54179534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.86217043
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.07965539
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.10316952
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.04346812
5CLOCK_20551151_ChIP-Seq_293T_Human3.76612563
6* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.13251903
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.84555653
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.83320819
9CJUN_26792858_Chip-Seq_BT549_Human2.65837843
10CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.63881073
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.60760830
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.51862652
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.47398071
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41258616
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39016158
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.27109463
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.12703351
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.08306625
19BRD4_25478319_ChIP-Seq_HGPS_Human2.06005297
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97595551
21LXR_22292898_ChIP-Seq_THP-1_Human1.92683231
22* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89536012
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.84227027
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80076413
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78726719
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77645995
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77645995
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.74936855
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71796198
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65756551
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.65301933
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.61216903
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.61216903
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.55538456
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.52875154
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52441053
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52332167
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51208505
39SMC1_22415368_ChIP-Seq_MEFs_Mouse1.48915370
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45668301
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45668301
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45656981
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.40287025
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40068822
45JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39772829
46TP53_18474530_ChIP-ChIP_U2OS_Human1.39599190
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38375514
48SOX2_20726797_ChIP-Seq_SW620_Human1.37740299
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36111193
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34611586
51* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33421544
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32190807
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32022553
54* UBF1/2_26484160_Chip-Seq_HMECs_Human1.30294155
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29233053
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25053470
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24936361
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.24801154
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24736329
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24463106
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24463106
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23997064
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.23148315
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.23048902
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22632584
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22166862
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21132355
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20016851
69* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18665692
70* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18047161
71TP53_23651856_ChIP-Seq_MEFs_Mouse1.17824650
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17785594
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.17042307
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16528695
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16450814
76SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15179490
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14803775
78TP53_16413492_ChIP-PET_HCT116_Human1.14452465
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14050821
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13309454
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.12899121
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12119076
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.11295134
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11046955
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10920401
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.10607753
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10487473
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10134659
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10048566
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09791753
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09466624
92RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09446974
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09082094
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08968764
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08033580
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07379505
97* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06891577
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06681990
99KDM2B_26808549_Chip-Seq_DND41_Human1.06527218
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05831305
101ATF3_27146783_Chip-Seq_COLON_Human1.05602311
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05354923
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.04853066
104TP53_22127205_ChIP-Seq_IMR90_Human1.03841569
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03661741
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02881507
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01413241
108SA1_22415368_ChIP-Seq_MEFs_Mouse1.01382008
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00989813
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00433195
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.00314507
112* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99611594
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97945178
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.97921466
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97696316
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97179947
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97039509
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96786918
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95358205
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93210097
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89600177
122KDM2B_26808549_Chip-Seq_K562_Human0.87999394
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86624084
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86544709
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85820568
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84256756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.40607591
2MP0005503_abnormal_tendon_morphology5.76234952
3MP0005275_abnormal_skin_tensile5.51106253
4MP0003705_abnormal_hypodermis_morpholog3.90889135
5MP0003279_aneurysm3.83092942
6MP0001958_emphysema3.67142169
7MP0004272_abnormal_basement_membrane3.18415647
8MP0005623_abnormal_meninges_morphology2.61619427
9MP0006054_spinal_hemorrhage2.46305396
10MP0009384_cardiac_valve_regurgitation2.34321888
11MP0010368_abnormal_lymphatic_system2.26947369
12MP0005508_abnormal_skeleton_morphology2.19564352
13MP0005257_abnormal_intraocular_pressure1.95915812
14MP0002108_abnormal_muscle_morphology1.95277492
15MP0003566_abnormal_cell_adhesion1.92773229
16MP0002295_abnormal_pulmonary_circulatio1.87470558
17MP0002060_abnormal_skin_morphology1.86452449
18MP0005023_abnormal_wound_healing1.82795450
19MP0001542_abnormal_bone_strength1.79940208
20MP0000751_myopathy1.72258949
21MP0001879_abnormal_lymphatic_vessel1.68429891
22MP0000767_abnormal_smooth_muscle1.58992375
23MP0004858_abnormal_nervous_system1.57200703
24MP0003091_abnormal_cell_migration1.50368530
25MP0009250_abnormal_appendicular_skeleto1.47024446
26MP0000013_abnormal_adipose_tissue1.44981023
27MP0003385_abnormal_body_wall1.44151070
28MP0010030_abnormal_orbit_morphology1.42706868
29MP0002896_abnormal_bone_mineralization1.37802989
30MP0000733_abnormal_muscle_development1.36813714
31MP0000750_abnormal_muscle_regeneration1.26841063
32MP0009780_abnormal_chondrocyte_physiolo1.26732767
33MP0000534_abnormal_ureter_morphology1.23903279
34MP0005390_skeleton_phenotype1.22442836
35MP0001243_abnormal_dermal_layer1.21534218
36MP0003045_fibrosis1.20145710
37MP0000749_muscle_degeneration1.19490524
38MP0004084_abnormal_cardiac_muscle1.19346179
39MP0002837_dystrophic_cardiac_calcinosis1.17831301
40MP0010352_gastrointestinal_tract_polyps1.15845482
41MP0002168_other_aberrant_phenotype1.14213061
42MP0003115_abnormal_respiratory_system1.12710014
43MP0001849_ear_inflammation1.12422458
44MP0003283_abnormal_digestive_organ1.12229802
45MP0002282_abnormal_trachea_morphology1.11708789
46MP0001299_abnormal_eye_distance/1.11433980
47MP0002254_reproductive_system_inflammat1.10692382
48MP0000163_abnormal_cartilage_morphology1.10648777
49MP0002933_joint_inflammation1.07913808
50MP0002115_abnormal_skeleton_extremities1.06963110
51MP0003942_abnormal_urinary_system1.06185455
52MP0004134_abnormal_chest_morphology1.05583529
53MP0005595_abnormal_vascular_smooth1.03392502
54MP0001348_abnormal_lacrimal_gland1.02607644
55MP0002998_abnormal_bone_remodeling0.99123513
56MP0002128_abnormal_blood_circulation0.98200571
57MP0006138_congestive_heart_failure0.97894278
58MP0000003_abnormal_adipose_tissue0.95791932
59MP0005058_abnormal_lysosome_morphology0.95726513
60MP0005164_abnormal_response_to0.93086151
61MP0000428_abnormal_craniofacial_morphol0.92994169
62MP0002932_abnormal_joint_morphology0.91619603
63MP0002113_abnormal_skeleton_development0.89411529
64MP0004087_abnormal_muscle_fiber0.89326896
65MP0000343_altered_response_to0.88314823
66MP0000759_abnormal_skeletal_muscle0.87597536
67MP0001614_abnormal_blood_vessel0.87226228
68MP0005367_renal/urinary_system_phenotyp0.86656075
69MP0000516_abnormal_urinary_system0.86656075
70MP0005388_respiratory_system_phenotype0.86201480
71MP0002133_abnormal_respiratory_system0.86201480
72MP0005369_muscle_phenotype0.85471234
73MP0001533_abnormal_skeleton_physiology0.83889977
74MP0005171_absent_coat_pigmentation0.83138366
75MP0001175_abnormal_lung_morphology0.81518102
76MP0004233_abnormal_muscle_weight0.81512150
77MP0010386_abnormal_urinary_bladder0.80553163
78MP0003950_abnormal_plasma_membrane0.80455062
79MP0008775_abnormal_heart_ventricle0.80452837
80MP0009053_abnormal_anal_canal0.80375465
81MP0000762_abnormal_tongue_morphology0.79703027
82MP0004883_abnormal_blood_vessel0.79475869
83MP0002877_abnormal_melanocyte_morpholog0.76779053
84MP0002249_abnormal_larynx_morphology0.76226790
85MP0000462_abnormal_digestive_system0.75814411
86MP0002925_abnormal_cardiovascular_devel0.75207288
87MP0005670_abnormal_white_adipose0.74432818
88MP0004185_abnormal_adipocyte_glucose0.73630176
89MP0009840_abnormal_foam_cell0.73606087
90MP0005385_cardiovascular_system_phenoty0.72980861
91MP0001544_abnormal_cardiovascular_syste0.72980861
92MP0003795_abnormal_bone_structure0.72264311
93MP0004036_abnormal_muscle_relaxation0.70567522
94MP0005375_adipose_tissue_phenotype0.70038126
95MP0003300_gastrointestinal_ulcer0.69994531
96MP0003935_abnormal_craniofacial_develop0.69330632
97MP0005330_cardiomyopathy0.69231234
98MP0003828_pulmonary_edema0.67904082
99MP0003448_altered_tumor_morphology0.67310605
100MP0002109_abnormal_limb_morphology0.67275683
101MP0005620_abnormal_muscle_contractility0.66591103
102MP0002116_abnormal_craniofacial_bone0.66170861
103MP0010630_abnormal_cardiac_muscle0.65767091
104MP0005076_abnormal_cell_differentiation0.65365817
105MP0003941_abnormal_skin_development0.65207405
106MP0002089_abnormal_postnatal_growth/wei0.64741020
107MP0005165_increased_susceptibility_to0.64138128
108MP0000681_abnormal_thyroid_gland0.64121336
109MP0000432_abnormal_head_morphology0.64065514
110MP0001915_intracranial_hemorrhage0.63912829
111MP0000049_abnormal_middle_ear0.63240928
112MP0002114_abnormal_axial_skeleton0.62646440
113MP0000249_abnormal_blood_vessel0.62252051
114MP0005197_abnormal_uvea_morphology0.62109214
115MP0003755_abnormal_palate_morphology0.61568686
116MP0000538_abnormal_urinary_bladder0.58319083
117MP0003191_abnormal_cellular_cholesterol0.56131341
118MP0005193_abnormal_anterior_eye0.53273726
119MP0000858_altered_metastatic_potential0.53127247
120MP0001661_extended_life_span0.52757603

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.67431374
2Premature rupture of membranes (HP:0001788)7.34129024
3Ankle contracture (HP:0006466)5.51619191
4Broad metatarsal (HP:0001783)5.33021069
5Aortic dissection (HP:0002647)5.16614109
6Aortic aneurysm (HP:0004942)4.76707422
7Shallow orbits (HP:0000586)4.71397726
8Soft skin (HP:0000977)4.45603683
9Cerebral aneurysm (HP:0004944)4.39967476
10Type 1 muscle fiber predominance (HP:0003803)4.16906110
11Bladder diverticulum (HP:0000015)4.08511771
12Atrophic scars (HP:0001075)4.05603904
13Cervical subluxation (HP:0003308)3.98683526
14Abnormality of dentin (HP:0010299)3.87010338
15Peritonitis (HP:0002586)3.86699688
16Dilatation of the ascending aorta (HP:0005111)3.79902818
17Spinal rigidity (HP:0003306)3.79553952
18Follicular hyperkeratosis (HP:0007502)3.68432710
19Vertebral compression fractures (HP:0002953)3.64310748
20Wrist flexion contracture (HP:0001239)3.60189627
21Increased connective tissue (HP:0009025)3.59653069
22Fragile skin (HP:0001030)3.55948026
23Wormian bones (HP:0002645)3.52247998
24Neonatal short-limb short stature (HP:0008921)3.32744783
25Blue sclerae (HP:0000592)3.28014756
26Mitral valve prolapse (HP:0001634)3.16669599
27Biconcave vertebral bodies (HP:0004586)3.16647854
28Vascular tortuosity (HP:0004948)3.12583880
29Genu recurvatum (HP:0002816)2.99769278
30Increased variability in muscle fiber diameter (HP:0003557)2.97786058
31Slender build (HP:0001533)2.87544980
32Hyperextensible skin (HP:0000974)2.78366155
33Round ear (HP:0100830)2.77818382
34Aneurysm (HP:0002617)2.77403345
35Mildly elevated creatine phosphokinase (HP:0008180)2.74105352
36Bowel diverticulosis (HP:0005222)2.73105157
37Overgrowth (HP:0001548)2.71004377
38Abnormality of skeletal muscle fiber size (HP:0012084)2.68489959
39Arterial tortuosity (HP:0005116)2.66408717
40Osteolytic defects of the hand bones (HP:0009699)2.64079302
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.64079302
42Camptodactyly of toe (HP:0001836)2.60855845
43Abnormal delivery (HP:0001787)2.56138243
44Hypoventilation (HP:0002791)2.55151066
45Spondylolisthesis (HP:0003302)2.51225876
46Aortic valve stenosis (HP:0001650)2.50809826
47Abnormality of the acetabulum (HP:0003170)2.47185322
48Joint laxity (HP:0001388)2.46763304
49Mild short stature (HP:0003502)2.44414273
50Elbow flexion contracture (HP:0002987)2.39346808
51Thin bony cortex (HP:0002753)2.34058486
52Bell-shaped thorax (HP:0001591)2.26047627
53Wide anterior fontanel (HP:0000260)2.24849527
54Ectopia lentis (HP:0001083)2.24546514
55Muscle fiber splitting (HP:0003555)2.23353387
56Ulnar bowing (HP:0003031)2.18566019
57Infantile muscular hypotonia (HP:0008947)2.16638849
58Mitral regurgitation (HP:0001653)2.13733399
59Nonimmune hydrops fetalis (HP:0001790)2.13525257
60Striae distensae (HP:0001065)2.13174689
61Broad ribs (HP:0000885)2.11979666
62Deviation of the hallux (HP:0010051)2.08415862
63Venous abnormality (HP:0002624)2.04849474
64Ovoid vertebral bodies (HP:0003300)2.01978033
65Flexion contracture of toe (HP:0005830)2.01352244
66Joint contractures involving the joints of the feet (HP:0100492)2.01352244
67Venous insufficiency (HP:0005293)1.99027977
68Knee flexion contracture (HP:0006380)1.98901586
69Short hallux (HP:0010109)1.96516943
70Right ventricular cardiomyopathy (HP:0011663)1.95932179
71Mesomelia (HP:0003027)1.95791206
72Osteoarthritis (HP:0002758)1.95599538
73Pulmonary artery stenosis (HP:0004415)1.95268349
74Breech presentation (HP:0001623)1.95044135
75Hallux valgus (HP:0001822)1.94890402
76Natal tooth (HP:0000695)1.94631501
77Protruding ear (HP:0000411)1.93886209
78Osteopenia (HP:0000938)1.93197423
79Short nail (HP:0001799)1.93105708
80Scapular winging (HP:0003691)1.93047511
81Generalized amyotrophy (HP:0003700)1.92934152
82Aortic regurgitation (HP:0001659)1.91732314
83Tarsal synostosis (HP:0008368)1.91255303
84Disproportionate tall stature (HP:0001519)1.90164358
85Delayed cranial suture closure (HP:0000270)1.90062366
86Coronal craniosynostosis (HP:0004440)1.89913560
87Femoral bowing (HP:0002980)1.89727431
88Distal upper limb amyotrophy (HP:0007149)1.89697971
89Upper limb amyotrophy (HP:0009129)1.89697971
90Abnormality of skull ossification (HP:0002703)1.89136298
91Achilles tendon contracture (HP:0001771)1.87552341
92Coxa vara (HP:0002812)1.86889160
93Joint stiffness (HP:0001387)1.85026542
94Ulnar deviation of the wrist (HP:0003049)1.84725579
95Emphysema (HP:0002097)1.83542665
96Delayed closure of the anterior fontanelle (HP:0001476)1.82586388
97Hypoplasia of the iris (HP:0007676)1.82237549
98Hip contracture (HP:0003273)1.81859832
99Inguinal hernia (HP:0000023)1.80346728
100Mitral stenosis (HP:0001718)1.80251504
101Buphthalmos (HP:0000557)1.79583628
102Persistence of primary teeth (HP:0006335)1.79073613
103Redundant skin (HP:0001582)1.78923334
104Long toe (HP:0010511)1.78889419
105Aplasia/Hypoplasia of the hallux (HP:0008362)1.78184172
106Flat cornea (HP:0007720)1.78106592
107Premature skin wrinkling (HP:0100678)1.77616660
108Abnormality of the peritoneum (HP:0002585)1.77543238
109Hematochezia (HP:0002573)1.77013021
110Difficulty climbing stairs (HP:0003551)1.76693566
111Obstructive sleep apnea (HP:0002870)1.74352257
112Renal duplication (HP:0000075)1.74280391
113Absent frontal sinuses (HP:0002688)1.73966572
114Tibial bowing (HP:0002982)1.73784220
115Hyporeflexia of lower limbs (HP:0002600)1.72974970
116Abnormality of the anterior chamber (HP:0000593)1.70879322
117Turricephaly (HP:0000262)1.70823204
118Bowed forearm bones (HP:0003956)1.70105146
119Bowing of the arm (HP:0006488)1.70105146
120Platyspondyly (HP:0000926)1.69754095
121Limb-girdle muscle weakness (HP:0003325)1.67984936
122Broad long bones (HP:0005622)1.65773228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.26910329
2TRIB34.12780499
3TTN4.12737494
4PDGFRA3.73534659
5ERN12.90079247
6LATS12.73152927
7TGFBR22.71748444
8MYLK2.58090345
9EPHB22.55324381
10TIE12.52402068
11LATS22.52146838
12SIK12.49496025
13PKN22.18548303
14RIPK12.08047827
15EPHA32.01028247
16PAK21.90741527
17FER1.77817896
18DMPK1.75323819
19MAP3K61.58288184
20PTK2B1.57081434
21PAK41.55536425
22NEK91.54522368
23TRPM71.48746184
24STK381.48530802
25PTK21.43959757
26AKT31.40305171
27PTK61.38825611
28LRRK21.38024507
29TESK11.35941324
30EPHB11.32062489
31BMX1.30265171
32MET1.29243231
33MOS1.25017632
34PDGFRB1.24291236
35ILK1.23838119
36PAK31.22524196
37ROCK11.20407473
38PIK3CA1.20251804
39KDR1.19732974
40STK31.18511371
41TGFBR11.14991752
42STK38L1.11783502
43MAPK71.06384291
44FGFR11.02373551
45FGFR41.01047792
46EPHA21.00094281
47LMTK20.97705089
48LIMK10.95804343
49RPS6KA40.95570013
50PIK3CG0.92399813
51FRK0.91447472
52PIM20.88924059
53ROCK20.86624866
54MTOR0.84790744
55GRK70.83489791
56PDK40.82303025
57PDK30.82303025
58GRK50.82092660
59MAP3K30.81997335
60MARK20.79903256
61MAP2K10.79362309
62PDK20.76786969
63NTRK10.75301413
64PRKD10.74481571
65PRPF4B0.74123137
66SMG10.73449079
67FLT30.72658058
68PAK60.72397848
69PRKD20.72139347
70CAMK1D0.71824163
71FGFR20.71399115
72PRKCH0.69866388
73RPS6KL10.67535266
74RPS6KC10.67535266
75MUSK0.66424461
76TAOK20.64849053
77JAK10.61704609
78PRKD30.60264844
79KIT0.58590831
80RET0.58205724
81OBSCN0.57798205
82EEF2K0.56300923
83ERBB30.55303931
84DAPK30.54086668
85MAPKAPK30.53913494
86FGFR30.53303771
87WNK10.52875485
88MAP2K30.52726793
89MST1R0.51389618
90INSR0.51265443
91CDC42BPA0.50113485
92ABL20.49175584
93RPS6KA60.48931049
94ERBB40.48272251
95PAK10.47351081
96CAMK1G0.44835677
97MAP3K100.44529786
98ARAF0.44445766
99HIPK20.43926417
100NUAK10.43526605
101CAMK2G0.43439736
102MAPK40.43242047
103ZAP700.42990861
104GSK3A0.41968382
105TYK20.40148281
106JAK30.40016734
107SRC0.39214504
108DYRK1B0.38232410
109PHKG20.37412993
110PHKG10.37412993
111ICK0.36245190
112TBK10.34792735
113ADRBK10.34170873
114MELK0.33607724
115PDPK10.33520530
116KSR20.33266724
117PRKG20.32923354
118CDK60.31814883
119STK100.31693945
120PLK20.31296852
121MAPK150.31110579
122CAMK10.30189959
123IGF1R0.29598030
124SCYL20.28529112
125CLK10.28285496
126PRKCE0.27886904
127MAPKAPK20.27189975
128CDK80.25509171
129MAPK10.24669785
130STK240.24628570
131CSK0.23818201
132MAP3K70.22041350
133RPS6KA20.21776921

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.85135957
2Focal adhesion_Homo sapiens_hsa045103.44618469
3Protein digestion and absorption_Homo sapiens_hsa049742.72594382
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.65226535
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.63080254
6Dilated cardiomyopathy_Homo sapiens_hsa054142.55151268
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.39921034
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.36635154
9Proteoglycans in cancer_Homo sapiens_hsa052052.30231705
10Malaria_Homo sapiens_hsa051442.27734658
11Amoebiasis_Homo sapiens_hsa051462.24066533
12TGF-beta signaling pathway_Homo sapiens_hsa043502.07384672
13Adherens junction_Homo sapiens_hsa045202.06629437
14Bladder cancer_Homo sapiens_hsa052191.96228788
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.88811950
16Small cell lung cancer_Homo sapiens_hsa052221.82192074
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.75441065
18Hippo signaling pathway_Homo sapiens_hsa043901.64864319
19Basal cell carcinoma_Homo sapiens_hsa052171.55656543
20MicroRNAs in cancer_Homo sapiens_hsa052061.46646266
21Melanoma_Homo sapiens_hsa052181.44878172
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40238305
23Viral myocarditis_Homo sapiens_hsa054161.38839880
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36123234
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.32782177
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.30500060
27Hedgehog signaling pathway_Homo sapiens_hsa043401.26584853
28Chronic myeloid leukemia_Homo sapiens_hsa052201.25954211
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21864696
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21112072
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.17825128
32Pathways in cancer_Homo sapiens_hsa052001.14167493
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13002135
34Tight junction_Homo sapiens_hsa045301.08730442
35Prostate cancer_Homo sapiens_hsa052151.07242257
36Rap1 signaling pathway_Homo sapiens_hsa040151.05650623
37Platelet activation_Homo sapiens_hsa046111.04745436
38Pancreatic cancer_Homo sapiens_hsa052121.02770694
39Toxoplasmosis_Homo sapiens_hsa051450.99695047
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.98420931
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95495175
42Glioma_Homo sapiens_hsa052140.91502653
43TNF signaling pathway_Homo sapiens_hsa046680.90770887
44Lysosome_Homo sapiens_hsa041420.87815082
45Ovarian steroidogenesis_Homo sapiens_hsa049130.87527178
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.87076220
47Wnt signaling pathway_Homo sapiens_hsa043100.85846560
48Insulin resistance_Homo sapiens_hsa049310.84859354
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84755417
50Phagosome_Homo sapiens_hsa041450.83768334
51HIF-1 signaling pathway_Homo sapiens_hsa040660.83080164
52Axon guidance_Homo sapiens_hsa043600.79366366
53PPAR signaling pathway_Homo sapiens_hsa033200.78821454
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78173973
55p53 signaling pathway_Homo sapiens_hsa041150.77416101
56Renin-angiotensin system_Homo sapiens_hsa046140.77078689
57HTLV-I infection_Homo sapiens_hsa051660.76854312
58Shigellosis_Homo sapiens_hsa051310.75280497
59Complement and coagulation cascades_Homo sapiens_hsa046100.74349441
60Vibrio cholerae infection_Homo sapiens_hsa051100.74270687
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74144873
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.73531282
63Renal cell carcinoma_Homo sapiens_hsa052110.72615361
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68519385
65Melanogenesis_Homo sapiens_hsa049160.67827873
66Notch signaling pathway_Homo sapiens_hsa043300.65402603
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64843882
68Gap junction_Homo sapiens_hsa045400.64635499
69Ras signaling pathway_Homo sapiens_hsa040140.64199677
70Thyroid hormone synthesis_Homo sapiens_hsa049180.63283745
71Estrogen signaling pathway_Homo sapiens_hsa049150.63243808
72Galactose metabolism_Homo sapiens_hsa000520.63090658
73AMPK signaling pathway_Homo sapiens_hsa041520.60142063
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59744770
75Cocaine addiction_Homo sapiens_hsa050300.59295049
76Prion diseases_Homo sapiens_hsa050200.57871569
77Endocytosis_Homo sapiens_hsa041440.57593565
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56833777
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56009140
80Apoptosis_Homo sapiens_hsa042100.55775998
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55489036
82Colorectal cancer_Homo sapiens_hsa052100.53974834
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53789242
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52437365
85Caffeine metabolism_Homo sapiens_hsa002320.52224511
86Thyroid cancer_Homo sapiens_hsa052160.51943586
87MAPK signaling pathway_Homo sapiens_hsa040100.51912697
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51890395
89Endometrial cancer_Homo sapiens_hsa052130.51120215
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50544487
91Acute myeloid leukemia_Homo sapiens_hsa052210.50117735
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50056162
93FoxO signaling pathway_Homo sapiens_hsa040680.49781093
94Salmonella infection_Homo sapiens_hsa051320.49673676
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.47982714
96N-Glycan biosynthesis_Homo sapiens_hsa005100.46701587
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45922907
98Choline metabolism in cancer_Homo sapiens_hsa052310.45507216
99Insulin signaling pathway_Homo sapiens_hsa049100.45404503
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44571926
101Sulfur relay system_Homo sapiens_hsa041220.42407347
102Other glycan degradation_Homo sapiens_hsa005110.42089788
103GnRH signaling pathway_Homo sapiens_hsa049120.41722962
104mTOR signaling pathway_Homo sapiens_hsa041500.41190450
105Sphingolipid metabolism_Homo sapiens_hsa006000.40085514
106Pertussis_Homo sapiens_hsa051330.39273778
107VEGF signaling pathway_Homo sapiens_hsa043700.39213229
108Hepatitis B_Homo sapiens_hsa051610.39191790
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38607057
110Oxytocin signaling pathway_Homo sapiens_hsa049210.38546819
111Prolactin signaling pathway_Homo sapiens_hsa049170.37028049
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.36690910
113Sulfur metabolism_Homo sapiens_hsa009200.35771323
114Glucagon signaling pathway_Homo sapiens_hsa049220.33584966
115Fatty acid degradation_Homo sapiens_hsa000710.33384038
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32636765
117Viral carcinogenesis_Homo sapiens_hsa052030.32280816

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