ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.78449751
2	DNA deamination (GO:0045006)	4.48214766
3	negative regulation of mast cell activation (GO:0033004)	4.26571767
4	sequestering of actin monomers (GO:0042989)	3.99246326
5	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.92127112
6	behavioral response to nicotine (GO:0035095)	3.91891600
7	somite development (GO:0061053)	3.86804614
8	kynurenine metabolic process (GO:0070189)	3.83125681
9	positive regulation of mitochondrial fission (GO:0090141)	3.82716298
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.49063568
11	indolalkylamine metabolic process (GO:0006586)	3.44686236
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.36790775
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.36348974
14	indole-containing compound catabolic process (GO:0042436)	3.33978274
15	indolalkylamine catabolic process (GO:0046218)	3.33978274
16	tryptophan catabolic process (GO:0006569)	3.33978274
17	sulfation (GO:0051923)	3.32143471
18	axoneme assembly (GO:0035082)	3.27482403
19	protein localization to cilium (GO:0061512)	3.22556472
20	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.21362647
21	protein polyglutamylation (GO:0018095)	3.19951666
22	GPI anchor metabolic process (GO:0006505)	3.19163065
23	epithelial cilium movement (GO:0003351)	3.16255091
24	piRNA metabolic process (GO:0034587)	3.11570111
25	platelet dense granule organization (GO:0060155)	3.09957930
26	cornea development in camera-type eye (GO:0061303)	3.04375094
27	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.03591077
28	endoderm formation (GO:0001706)	3.01128114
29	detection of light stimulus involved in sensory perception (GO:0050962)	2.99790218
30	detection of light stimulus involved in visual perception (GO:0050908)	2.99790218
31	tachykinin receptor signaling pathway (GO:0007217)	2.97694298
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.97100585
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.97100585
34	NADH dehydrogenase complex assembly (GO:0010257)	2.97100585
35	tryptophan metabolic process (GO:0006568)	2.96898986
36	regulation of action potential (GO:0098900)	2.93928063
37	rhodopsin mediated signaling pathway (GO:0016056)	2.92942712
38	regulation of cilium movement (GO:0003352)	2.88662883
39	multicellular organism reproduction (GO:0032504)	2.87783448
40	gamma-aminobutyric acid transport (GO:0015812)	2.87359741
41	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.86967415
42	actin nucleation (GO:0045010)	2.86279223
43	base-excision repair, AP site formation (GO:0006285)	2.85280898
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.84200375
45	embryonic epithelial tube formation (GO:0001838)	2.82930880
46	positive regulation of glomerulus development (GO:0090193)	2.79960901
47	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.74605153
48	indole-containing compound metabolic process (GO:0042430)	2.74309196
49	regulation of mitochondrial fission (GO:0090140)	2.73746220
50	fucose catabolic process (GO:0019317)	2.73353875
51	L-fucose metabolic process (GO:0042354)	2.73353875
52	L-fucose catabolic process (GO:0042355)	2.73353875
53	cytidine metabolic process (GO:0046087)	2.71867736
54	cytidine catabolic process (GO:0006216)	2.71867736
55	cytidine deamination (GO:0009972)	2.71867736
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.71706078
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.71706078
58	protein complex biogenesis (GO:0070271)	2.71186299
59	positive regulation of calcium-mediated signaling (GO:0050850)	2.67979485
60	iron-sulfur cluster assembly (GO:0016226)	2.67963116
61	metallo-sulfur cluster assembly (GO:0031163)	2.67963116
62	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.65879554
63	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.65448849
64	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.65448849
65	mannosylation (GO:0097502)	2.64519006
66	rRNA catabolic process (GO:0016075)	2.62940087
67	neural tube formation (GO:0001841)	2.62841583
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.62467673
69	regulation of mesoderm development (GO:2000380)	2.61021209
70	epithelial tube formation (GO:0072175)	2.60911640
71	negative T cell selection (GO:0043383)	2.60856529
72	primary amino compound metabolic process (GO:1901160)	2.60265488
73	protein neddylation (GO:0045116)	2.57918027
74	sperm motility (GO:0030317)	2.55607598
75	transmission of nerve impulse (GO:0019226)	2.55013031
76	negative regulation of telomere maintenance (GO:0032205)	2.54130019
77	amino acid salvage (GO:0043102)	2.51507621
78	L-methionine salvage (GO:0071267)	2.51507621
79	L-methionine biosynthetic process (GO:0071265)	2.51507621
80	C4-dicarboxylate transport (GO:0015740)	2.50127817
81	sleep (GO:0030431)	2.49899484
82	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49837986
83	neuronal action potential (GO:0019228)	2.48241778
84	behavioral response to ethanol (GO:0048149)	2.47427954
85	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.47370261
86	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.47140801
87	parturition (GO:0007567)	2.46519137
88	phosphatidylethanolamine metabolic process (GO:0046337)	2.46279738
89	negative regulation of astrocyte differentiation (GO:0048712)	2.45713094
90	benzene-containing compound metabolic process (GO:0042537)	2.45447042
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.44171857
92	cilium movement (GO:0003341)	2.42720369
93	GPI anchor biosynthetic process (GO:0006506)	2.41906459
94	DNA methylation involved in gamete generation (GO:0043046)	2.41377371
95	cellular ketone body metabolic process (GO:0046950)	2.41371542
96	cilium or flagellum-dependent cell motility (GO:0001539)	2.41157156
97	transepithelial transport (GO:0070633)	2.41026091
98	positive regulation of action potential (GO:0045760)	2.39611350
99	regulation of glomerulus development (GO:0090192)	2.38988531
100	cellular response to interleukin-15 (GO:0071350)	2.38405209

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.56534464
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.50629718
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.45385656
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39000097
5	VDR_22108803_ChIP-Seq_LS180_Human	2.94196501
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.87260482
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.49983740
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.26782755
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22394117
10	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20166463
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14366789
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.10965326
13	P300_19829295_ChIP-Seq_ESCs_Human	1.85318273
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.83132467
15	FUS_26573619_Chip-Seq_HEK293_Human	1.81548277
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.77284783
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73610066
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73292197
19	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.70935286
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68693004
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64575613
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63740079
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61389101
24	EWS_26573619_Chip-Seq_HEK293_Human	1.57396915
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.55580049
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55580049
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50128758
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.47304951
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47034998
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45423502
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43376414
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43050099
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.41988735
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37117318
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33243279
36	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.32671559
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31741568
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31566023
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31566023
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.31253489
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.30640669
42	AR_25329375_ChIP-Seq_VCAP_Human	1.29356582
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27179768
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25629550
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25113894
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25113894
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.23795166
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23103294
49	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22773379
50	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21965525
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21706157
52	AR_20517297_ChIP-Seq_VCAP_Human	1.19978649
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19924530
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19864804
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19203273
56	NCOR_22424771_ChIP-Seq_293T_Human	1.18203944
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.17654633
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17239073
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17064270
60	STAT3_23295773_ChIP-Seq_U87_Human	1.16985593
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15193483
62	TCF4_23295773_ChIP-Seq_U87_Human	1.14298482
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14207994
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13770585
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.12635709
66	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12166859
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11580755
68	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.11413903
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11284559
70	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11150745
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10992686
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10557216
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10345574
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10009223
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09786407
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08092338
77	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.07666274
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05650831
79	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.05615920
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04308576
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03526650
82	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.03494892
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.03078580
84	* TCF4_22108803_ChIP-Seq_LS180_Human	1.01714309
85	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00385849
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99437027
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98815838
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98543091
89	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.98228626
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98137163
91	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.97909977
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97846674
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97771159
94	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97621804
95	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.97509943
96	* MYC_19829295_ChIP-Seq_ESCs_Human	0.97493694
97	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.96990005
98	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96845553
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96076998
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95884345

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.46743174
2	MP0005646_abnormal_pituitary_gland	3.01248784
3	MP0006072_abnormal_retinal_apoptosis	2.78196395
4	MP0005671_abnormal_response_to	2.71435147
5	MP0003011_delayed_dark_adaptation	2.59940057
6	MP0003880_abnormal_central_pattern	2.42386353
7	MP0003724_increased_susceptibility_to	2.38204462
8	MP0005551_abnormal_eye_electrophysiolog	2.24854271
9	MP0004885_abnormal_endolymph	2.18686707
10	MP0005645_abnormal_hypothalamus_physiol	2.16877881
11	MP0005253_abnormal_eye_physiology	2.14300764
12	MP0001968_abnormal_touch/_nociception	2.08651769
13	MP0008877_abnormal_DNA_methylation	2.07791567
14	MP0001529_abnormal_vocalization	1.97727594
15	MP0005670_abnormal_white_adipose	1.87404883
16	MP0003646_muscle_fatigue	1.80843476
17	MP0002837_dystrophic_cardiac_calcinosis	1.75886724
18	MP0006292_abnormal_olfactory_placode	1.75422941
19	MP0002638_abnormal_pupillary_reflex	1.73544306
20	MP0006276_abnormal_autonomic_nervous	1.66250681
21	MP0009745_abnormal_behavioral_response	1.65494148
22	MP0000049_abnormal_middle_ear	1.59358597
23	MP0002822_catalepsy	1.54890326
24	MP0002272_abnormal_nervous_system	1.52729453
25	MP0005410_abnormal_fertilization	1.52023969
26	MP0001486_abnormal_startle_reflex	1.51550242
27	MP0003195_calcinosis	1.51164838
28	MP0001485_abnormal_pinna_reflex	1.47979037
29	MP0002234_abnormal_pharynx_morphology	1.46278217
30	MP0008875_abnormal_xenobiotic_pharmacok	1.45358290
31	MP0002138_abnormal_hepatobiliary_system	1.44768667
32	MP0000631_abnormal_neuroendocrine_gland	1.43481588
33	MP0002736_abnormal_nociception_after	1.42511875
34	MP0004145_abnormal_muscle_electrophysio	1.41560779
35	MP0001984_abnormal_olfaction	1.41062289
36	MP0008872_abnormal_physiological_respon	1.40961939
37	MP0004133_heterotaxia	1.40710790
38	MP0001986_abnormal_taste_sensitivity	1.36375824
39	MP0002735_abnormal_chemical_nociception	1.34767848
40	MP0009046_muscle_twitch	1.28033725
41	MP0005084_abnormal_gallbladder_morpholo	1.27329572
42	MP0003119_abnormal_digestive_system	1.26853818
43	MP0002751_abnormal_autonomic_nervous	1.26520725
44	MP0002876_abnormal_thyroid_physiology	1.26286310
45	MP0004142_abnormal_muscle_tone	1.26011904
46	MP0001501_abnormal_sleep_pattern	1.25789488
47	MP0010386_abnormal_urinary_bladder	1.24872716
48	MP0005389_reproductive_system_phenotype	1.23963608
49	MP0001764_abnormal_homeostasis	1.21551565
50	MP0000372_irregular_coat_pigmentation	1.20959632
51	MP0004859_abnormal_synaptic_plasticity	1.18509726
52	MP0008789_abnormal_olfactory_epithelium	1.17814818
53	MP0001919_abnormal_reproductive_system	1.16520295
54	MP0002572_abnormal_emotion/affect_behav	1.13582242
55	MP0004147_increased_porphyrin_level	1.11042139
56	MP0000026_abnormal_inner_ear	1.08917174
57	MP0001970_abnormal_pain_threshold	1.08594968
58	MP0003938_abnormal_ear_development	1.07877772
59	MP0001963_abnormal_hearing_physiology	1.07269131
60	MP0003635_abnormal_synaptic_transmissio	1.07059084
61	MP0002653_abnormal_ependyma_morphology	1.06927445
62	MP0001905_abnormal_dopamine_level	1.05603148
63	MP0002160_abnormal_reproductive_system	1.05355094
64	MP0002282_abnormal_trachea_morphology	1.04650525
65	MP0008995_early_reproductive_senescence	1.03471673
66	MP0005085_abnormal_gallbladder_physiolo	1.02829093
67	MP0002064_seizures	1.00541944
68	MP0002733_abnormal_thermal_nociception	0.98321381
69	MP0002557_abnormal_social/conspecific_i	0.97882051
70	MP0002752_abnormal_somatic_nervous	0.97012581
71	MP0005195_abnormal_posterior_eye	0.96842274
72	MP0009053_abnormal_anal_canal	0.96759590
73	MP0000013_abnormal_adipose_tissue	0.96601074
74	MP0002063_abnormal_learning/memory/cond	0.96501767
75	MP0005394_taste/olfaction_phenotype	0.95676210
76	MP0005499_abnormal_olfactory_system	0.95676210
77	MP0005167_abnormal_blood-brain_barrier	0.94285474
78	MP0004043_abnormal_pH_regulation	0.92613604
79	MP0005075_abnormal_melanosome_morpholog	0.90115988
80	MP0002184_abnormal_innervation	0.88082515
81	MP0002734_abnormal_mechanical_nocicepti	0.85570022
82	MP0003878_abnormal_ear_physiology	0.85225313
83	MP0005377_hearing/vestibular/ear_phenot	0.85225313
84	MP0002928_abnormal_bile_duct	0.84698131
85	MP0003787_abnormal_imprinting	0.83706140
86	MP0008775_abnormal_heart_ventricle	0.81303705
87	MP0005423_abnormal_somatic_nervous	0.80064512
88	MP0009785_altered_susceptibility_to	0.79276230
89	MP0005360_urolithiasis	0.79207379
90	MP0000427_abnormal_hair_cycle	0.78859823
91	MP0005365_abnormal_bile_salt	0.78852250
92	MP0003698_abnormal_male_reproductive	0.78761735
93	MP0001440_abnormal_grooming_behavior	0.76149255
94	MP0004130_abnormal_muscle_cell	0.74647775
95	MP0003137_abnormal_impulse_conducting	0.74287424
96	MP0004924_abnormal_behavior	0.73904982
97	MP0005386_behavior/neurological_phenoty	0.73904982
98	MP0009764_decreased_sensitivity_to	0.73176545
99	MP0001835_abnormal_antigen_presentation	0.71791473
100	MP0005187_abnormal_penis_morphology	0.70713410

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.94654068
2	Congenital stationary night blindness (HP:0007642)	3.74470660
3	True hermaphroditism (HP:0010459)	3.73615414
4	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.66622318
5	Short 1st metacarpal (HP:0010034)	3.66622318
6	Nephronophthisis (HP:0000090)	3.43286167
7	Pancreatic fibrosis (HP:0100732)	3.37918048
8	Renal cortical cysts (HP:0000803)	3.35777167
9	Humeroradial synostosis (HP:0003041)	3.26894697
10	Synostosis involving the elbow (HP:0003938)	3.26894697
11	Abnormality of the 1st metacarpal (HP:0010009)	3.26135060
12	Attenuation of retinal blood vessels (HP:0007843)	3.23081932
13	Abnormality of the renal cortex (HP:0011035)	3.22124051
14	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.15921182
15	Abolished electroretinogram (ERG) (HP:0000550)	3.10405861
16	IgG deficiency (HP:0004315)	2.92008907
17	Abnormality of the renal medulla (HP:0100957)	2.83068732
18	Keratoconus (HP:0000563)	2.81287719
19	Increased corneal curvature (HP:0100692)	2.81287719
20	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.78937402
21	Medial flaring of the eyebrow (HP:0010747)	2.78198305
22	Morphological abnormality of the middle ear (HP:0008609)	2.75723547
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.75476099
24	Abnormality of midbrain morphology (HP:0002418)	2.68237346
25	Molar tooth sign on MRI (HP:0002419)	2.68237346
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.62518812
27	Methylmalonic acidemia (HP:0002912)	2.61995270
28	Adactyly (HP:0009776)	2.57430560
29	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.57420667
30	Decreased central vision (HP:0007663)	2.51464356
31	Acute necrotizing encephalopathy (HP:0006965)	2.51413954
32	Pendular nystagmus (HP:0012043)	2.50579053
33	Methylmalonic aciduria (HP:0012120)	2.43712439
34	Gait imbalance (HP:0002141)	2.43160602
35	Congenital primary aphakia (HP:0007707)	2.40514426
36	Stenosis of the external auditory canal (HP:0000402)	2.38475127
37	Type II lissencephaly (HP:0007260)	2.36375478
38	Mitochondrial inheritance (HP:0001427)	2.35840706
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.35123297
40	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.34406765
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.32755727
42	Short tibia (HP:0005736)	2.32648073
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.31555344
44	Nephrogenic diabetes insipidus (HP:0009806)	2.30363576
45	Amyotrophic lateral sclerosis (HP:0007354)	2.30086551
46	Abnormality of the middle phalanges of the toes (HP:0010183)	2.30059496
47	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.29920334
48	Chronic hepatic failure (HP:0100626)	2.29482294
49	Short phalanx of the thumb (HP:0009660)	2.26355656
50	Severe combined immunodeficiency (HP:0004430)	2.24998643
51	Asplenia (HP:0001746)	2.24780873
52	Stomach cancer (HP:0012126)	2.24517109
53	Cystic liver disease (HP:0006706)	2.23016195
54	Sclerocornea (HP:0000647)	2.22392993
55	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.20544766
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16582919
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.16449670
58	Postaxial foot polydactyly (HP:0001830)	2.15556205
59	Short hallux (HP:0010109)	2.15440544
60	Increased CSF lactate (HP:0002490)	2.12135543
61	Progressive macrocephaly (HP:0004481)	2.11235232
62	Congenital sensorineural hearing impairment (HP:0008527)	2.10653993
63	3-Methylglutaconic aciduria (HP:0003535)	2.09333056
64	Acute encephalopathy (HP:0006846)	2.07798779
65	Hepatocellular necrosis (HP:0001404)	2.07678970
66	Hyperventilation (HP:0002883)	2.06593995
67	Thyroiditis (HP:0100646)	2.06137895
68	Lissencephaly (HP:0001339)	1.98996346
69	Hypoproteinemia (HP:0003075)	1.98374920
70	Tubular atrophy (HP:0000092)	1.98173032
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96536033
72	Absent/shortened dynein arms (HP:0200106)	1.96536033
73	Optic disc pallor (HP:0000543)	1.95281748
74	Genital tract atresia (HP:0001827)	1.94087224
75	Congenital hepatic fibrosis (HP:0002612)	1.93608996
76	Polydipsia (HP:0001959)	1.93229361
77	Abnormal drinking behavior (HP:0030082)	1.93229361
78	Vaginal atresia (HP:0000148)	1.92994266
79	Hyperglycinemia (HP:0002154)	1.92686139
80	Thyroid-stimulating hormone excess (HP:0002925)	1.91980677
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.89979700
82	Abnormal respiratory motile cilium morphology (HP:0005938)	1.89979700
83	Aplasia/hypoplasia of the uterus (HP:0008684)	1.88739412
84	Fibular aplasia (HP:0002990)	1.87384583
85	Male pseudohermaphroditism (HP:0000037)	1.86453238
86	Retinal dysplasia (HP:0007973)	1.85289375
87	Postaxial hand polydactyly (HP:0001162)	1.83548720
88	Severe muscular hypotonia (HP:0006829)	1.83167195
89	Chorioretinal atrophy (HP:0000533)	1.80520086
90	Hepatic necrosis (HP:0002605)	1.79989138
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77581248
92	Synostosis of carpal bones (HP:0005048)	1.76740253
93	Inability to walk (HP:0002540)	1.76660547
94	Abnormality of alanine metabolism (HP:0010916)	1.76297165
95	Hyperalaninemia (HP:0003348)	1.76297165
96	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76297165
97	Abnormality of the nasal septum (HP:0000419)	1.75335332
98	Genetic anticipation (HP:0003743)	1.74175122
99	Hypoplasia of the uterus (HP:0000013)	1.72461462
100	Abnormality of the costochondral junction (HP:0000919)	1.71769599

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.34793933
2	TESK2	3.00664267
3	GRK1	2.90175745
4	TXK	2.79035489
5	MAP3K4	2.67366792
6	ADRBK2	2.60791928
7	TAOK3	2.60626582
8	FRK	2.52033556
9	KDR	2.41836486
10	MAP2K7	2.26037114
11	WNK3	2.23526188
12	TLK1	2.02082873
13	BCKDK	1.98122094
14	MAPK13	1.83969143
15	ZAK	1.83662103
16	PINK1	1.77487849
17	CDK19	1.72469432
18	BCR	1.67647157
19	INSRR	1.57326772
20	ERBB3	1.55408413
21	MUSK	1.55319875
22	LIMK1	1.49231404
23	CAMKK2	1.38916958
24	CSNK1G3	1.38439817
25	TIE1	1.35026801
26	CSNK1G2	1.34336671
27	DYRK3	1.32724693
28	MARK1	1.31796922
29	WNK4	1.29443175
30	CSNK1A1L	1.21329700
31	RPS6KA4	1.18750281
32	NUAK1	1.17208021
33	ITK	1.13640776
34	TRIM28	1.10782259
35	NME1	1.09640094
36	CASK	1.08368234
37	CSNK1G1	1.08254463
38	TESK1	1.07378785
39	EPHA4	1.05039176
40	GRK6	1.01582613
41	OXSR1	1.01077665
42	MAP4K1	1.00167868
43	DAPK2	0.95188572
44	PLK2	0.94426455
45	DYRK2	0.93265930
46	TEC	0.91968622
47	GRK7	0.91745511
48	BMPR1B	0.83304452
49	SYK	0.81816557
50	RPS6KA5	0.79606601
51	PRKCE	0.77202643
52	STK39	0.75658577
53	IKBKE	0.75180709
54	CAMKK1	0.74954005
55	PASK	0.74154164
56	KIT	0.72494241
57	DYRK1B	0.71285520
58	CDK8	0.70571244
59	ADRBK1	0.70461386
60	FES	0.68325753
61	PAK6	0.67565866
62	IKBKB	0.66163622
63	LCK	0.65137875
64	FER	0.63954714
65	PAK3	0.63947890
66	MAPKAPK3	0.62089691
67	LYN	0.60949383
68	PRKCQ	0.59522180
69	CAMK2A	0.59061712
70	OBSCN	0.58575206
71	PLK4	0.57389626
72	EPHA3	0.55706593
73	NTRK2	0.55071894
74	PRKACA	0.53923924
75	CAMK4	0.53470113
76	STK38L	0.51956950
77	PHKG1	0.51038896
78	PHKG2	0.51038896
79	PRKCG	0.50717323
80	SIK2	0.49724894
81	DYRK1A	0.49448539
82	PKN1	0.49342165
83	MAP2K2	0.49086507
84	CAMK1	0.48442945
85	IGF1R	0.47180460
86	FLT3	0.46391022
87	ERBB2	0.45086148
88	TNK2	0.43237256
89	PRKCA	0.40585412
90	MATK	0.40469912
91	SIK3	0.39513370
92	VRK1	0.39344763
93	CSF1R	0.38811960
94	MAP3K5	0.38667630
95	CAMK2B	0.36431906
96	BTK	0.36022345
97	CSNK1A1	0.35910065
98	ABL1	0.34738174
99	PIK3CG	0.33790306
100	AURKA	0.33644617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.11277386
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.87311352
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.79323555
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.49794257
5	Nicotine addiction_Homo sapiens_hsa05033	2.45307379
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.14126995
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.09872341
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07427604
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00835595
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.93008935
11	Protein export_Homo sapiens_hsa03060	1.85655521
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83239730
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.81029782
14	Taste transduction_Homo sapiens_hsa04742	1.79539236
15	Parkinsons disease_Homo sapiens_hsa05012	1.78610002
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70065699
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.65715460
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.64189635
19	Morphine addiction_Homo sapiens_hsa05032	1.62551514
20	Asthma_Homo sapiens_hsa05310	1.60048925
21	Caffeine metabolism_Homo sapiens_hsa00232	1.53167466
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.45870140
23	Butanoate metabolism_Homo sapiens_hsa00650	1.42875821
24	Olfactory transduction_Homo sapiens_hsa04740	1.41920519
25	Allograft rejection_Homo sapiens_hsa05330	1.39295789
26	GABAergic synapse_Homo sapiens_hsa04727	1.38929317
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.35064585
28	Retinol metabolism_Homo sapiens_hsa00830	1.34830127
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33137707
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27322796
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.26890445
32	Regulation of autophagy_Homo sapiens_hsa04140	1.26413740
33	RNA degradation_Homo sapiens_hsa03018	1.26340413
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26153319
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24383952
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.23812871
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22891233
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22695361
39	Alzheimers disease_Homo sapiens_hsa05010	1.21459046
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21331518
41	Basal transcription factors_Homo sapiens_hsa03022	1.19892543
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.19800716
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15814152
44	Huntingtons disease_Homo sapiens_hsa05016	1.15669471
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.13984384
46	RNA polymerase_Homo sapiens_hsa03020	1.10033842
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.08560659
48	Circadian entrainment_Homo sapiens_hsa04713	1.06409358
49	Antigen processing and presentation_Homo sapiens_hsa04612	1.04061420
50	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03656382
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03654270
52	Sulfur metabolism_Homo sapiens_hsa00920	1.00692782
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97337320
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96546782
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95869784
56	Peroxisome_Homo sapiens_hsa04146	0.95671811
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94235068
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.93893598
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93464406
60	Propanoate metabolism_Homo sapiens_hsa00640	0.92973981
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.91334797
62	Salivary secretion_Homo sapiens_hsa04970	0.90610595
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.87219041
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83821947
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.81917047
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.80930570
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.80227987
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78916146
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78275409
70	Fatty acid elongation_Homo sapiens_hsa00062	0.73566798
71	Proteasome_Homo sapiens_hsa03050	0.73552331
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73153976
73	Serotonergic synapse_Homo sapiens_hsa04726	0.72280061
74	Homologous recombination_Homo sapiens_hsa03440	0.68975586
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67441255
76	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66771882
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66377605
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63407300
79	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60276058
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60175549
81	ABC transporters_Homo sapiens_hsa02010	0.57599201
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.56767996
83	Metabolic pathways_Homo sapiens_hsa01100	0.55157143
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54908019
85	Purine metabolism_Homo sapiens_hsa00230	0.52513858
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.50685271
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50404423
88	One carbon pool by folate_Homo sapiens_hsa00670	0.48126321
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45727565
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.43530961
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42905352
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42899554
93	Viral myocarditis_Homo sapiens_hsa05416	0.40583682
94	Amphetamine addiction_Homo sapiens_hsa05031	0.39432979
95	Insulin secretion_Homo sapiens_hsa04911	0.38446298
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.38143145
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37903389
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37144640
99	Renin secretion_Homo sapiens_hsa04924	0.31911343
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31453141

MYADML

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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