

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | actin-myosin filament sliding (GO:0033275) | 9.11058974 |
| 2 | muscle filament sliding (GO:0030049) | 9.11058974 |
| 3 | sarcomere organization (GO:0045214) | 8.60694537 |
| 4 | regulation of skeletal muscle contraction (GO:0014819) | 8.21871609 |
| 5 | actin-mediated cell contraction (GO:0070252) | 7.43830920 |
| 6 | myofibril assembly (GO:0030239) | 7.41439447 |
| 7 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.36670913 |
| 8 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 7.18561972 |
| 9 | cardiac myofibril assembly (GO:0055003) | 7.14297702 |
| 10 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.10461911 |
| 11 | skeletal muscle fiber development (GO:0048741) | 6.97892373 |
| 12 | plasma membrane repair (GO:0001778) | 6.86010003 |
| 13 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.72989823 |
| 14 | skeletal muscle contraction (GO:0003009) | 6.54542271 |
| 15 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.28078972 |
| 16 | myotube cell development (GO:0014904) | 6.26582439 |
| 17 | cardiac muscle contraction (GO:0060048) | 6.23116263 |
| 18 | striated muscle contraction (GO:0006941) | 6.13648232 |
| 19 | tricarboxylic acid cycle (GO:0006099) | 6.12836151 |
| 20 | carnitine shuttle (GO:0006853) | 5.97092111 |
| 21 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.86363455 |
| 22 | regulation of cell communication by electrical coupling (GO:0010649) | 5.84180976 |
| 23 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.82104175 |
| 24 | regulation of relaxation of muscle (GO:1901077) | 5.81914054 |
| 25 | actin filament-based movement (GO:0030048) | 5.59502593 |
| 26 | actomyosin structure organization (GO:0031032) | 5.54155025 |
| 27 | cardiac muscle cell development (GO:0055013) | 5.42494821 |
| 28 | skeletal muscle adaptation (GO:0043501) | 5.41534951 |
| 29 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.40777021 |
| 30 | regulation of actin filament-based movement (GO:1903115) | 5.33943594 |
| 31 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 5.33044985 |
| 32 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.25416485 |
| 33 | fatty acid transmembrane transport (GO:1902001) | 5.06420641 |
| 34 | cardiac cell development (GO:0055006) | 5.06101006 |
| 35 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 5.05305088 |
| 36 | creatine metabolic process (GO:0006600) | 5.01518761 |
| 37 | regulation of coenzyme metabolic process (GO:0051196) | 4.89210506 |
| 38 | regulation of cofactor metabolic process (GO:0051193) | 4.89210506 |
| 39 | skeletal muscle tissue development (GO:0007519) | 4.86641987 |
| 40 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.78191371 |
| 41 | cardiac muscle hypertrophy (GO:0003300) | 4.76059356 |
| 42 | heart process (GO:0003015) | 4.75816505 |
| 43 | heart contraction (GO:0060047) | 4.75816505 |
| 44 | striated muscle hypertrophy (GO:0014897) | 4.65113051 |
| 45 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.62210433 |
| 46 | regulation of striated muscle contraction (GO:0006942) | 4.57347135 |
| 47 | skeletal muscle tissue regeneration (GO:0043403) | 4.56549401 |
| 48 | glycogen catabolic process (GO:0005980) | 4.49782296 |
| 49 | regulation of sarcomere organization (GO:0060297) | 4.47627567 |
| 50 | adult heart development (GO:0007512) | 4.41586607 |
| 51 | muscle contraction (GO:0006936) | 4.40141495 |
| 52 | carnitine transmembrane transport (GO:1902603) | 4.37631890 |
| 53 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.34805434 |
| 54 | regulation of membrane repolarization (GO:0060306) | 4.34287935 |
| 55 | muscle tissue morphogenesis (GO:0060415) | 4.27439577 |
| 56 | positive regulation of myotube differentiation (GO:0010831) | 4.26283586 |
| 57 | fructose metabolic process (GO:0006000) | 4.25294580 |
| 58 | response to inactivity (GO:0014854) | 4.18765608 |
| 59 | glucan catabolic process (GO:0009251) | 4.18638349 |
| 60 | muscle organ morphogenesis (GO:0048644) | 4.17620954 |
| 61 | striated muscle adaptation (GO:0014888) | 4.13783220 |
| 62 | glycogen metabolic process (GO:0005977) | 4.09134421 |
| 63 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.08444636 |
| 64 | muscle hypertrophy (GO:0014896) | 4.08106984 |
| 65 | oxidative phosphorylation (GO:0006119) | 4.05485073 |
| 66 | muscle organ development (GO:0007517) | 4.03681799 |
| 67 | muscle structure development (GO:0061061) | 4.03279152 |
| 68 | heart trabecula formation (GO:0060347) | 4.03121471 |
| 69 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.02172751 |
| 70 | muscle system process (GO:0003012) | 4.01800636 |
| 71 | muscle cell fate commitment (GO:0042693) | 4.01517386 |
| 72 | cellular glucan metabolic process (GO:0006073) | 4.01072334 |
| 73 | glucan metabolic process (GO:0044042) | 4.01072334 |
| 74 | carnitine transport (GO:0015879) | 3.96294099 |
| 75 | amino-acid betaine transport (GO:0015838) | 3.96294099 |
| 76 | gluconeogenesis (GO:0006094) | 3.95578553 |
| 77 | NADH metabolic process (GO:0006734) | 3.95500809 |
| 78 | response to muscle activity (GO:0014850) | 3.94641931 |
| 79 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.92537294 |
| 80 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.90331605 |
| 81 | response to activity (GO:0014823) | 3.89538721 |
| 82 | cellular polysaccharide catabolic process (GO:0044247) | 3.89419194 |
| 83 | regulation of sulfur metabolic process (GO:0042762) | 3.87961016 |
| 84 | striated muscle cell development (GO:0055002) | 3.83419421 |
| 85 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.82867268 |
| 86 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.82867268 |
| 87 | cytidine deamination (GO:0009972) | 3.79928471 |
| 88 | cytidine metabolic process (GO:0046087) | 3.79928471 |
| 89 | cytidine catabolic process (GO:0006216) | 3.79928471 |
| 90 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.79476848 |
| 91 | striated muscle atrophy (GO:0014891) | 3.79292509 |
| 92 | neuronal action potential propagation (GO:0019227) | 3.77717876 |
| 93 | respiratory electron transport chain (GO:0022904) | 3.72864260 |
| 94 | myoblast fusion (GO:0007520) | 3.71049564 |
| 95 | 2-oxoglutarate metabolic process (GO:0006103) | 3.68458225 |
| 96 | muscle fiber development (GO:0048747) | 3.67783748 |
| 97 | polysaccharide catabolic process (GO:0000272) | 3.66155150 |
| 98 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.65213295 |
| 99 | electron transport chain (GO:0022900) | 3.61895014 |
| 100 | muscle hypertrophy in response to stress (GO:0003299) | 3.58365018 |
| 101 | cardiac muscle adaptation (GO:0014887) | 3.58365018 |
| 102 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.58365018 |
| 103 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.56865620 |
| 104 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.56865620 |
| 105 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.54142776 |
| 106 | hexose biosynthetic process (GO:0019319) | 3.54128444 |
| 107 | regulation of the force of heart contraction (GO:0002026) | 3.53118026 |
| 108 | ATP synthesis coupled proton transport (GO:0015986) | 3.52356101 |
| 109 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.52356101 |
| 110 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.52054690 |
| 111 | IMP metabolic process (GO:0046040) | 3.51723265 |
| 112 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.51148901 |
| 113 | negative regulation of potassium ion transport (GO:0043267) | 3.50202737 |
| 114 | positive regulation of cation channel activity (GO:2001259) | 3.49865665 |
| 115 | glycogen biosynthetic process (GO:0005978) | 3.49136270 |
| 116 | glucan biosynthetic process (GO:0009250) | 3.49136270 |
| 117 | regulation of myoblast differentiation (GO:0045661) | 3.49113699 |
| 118 | negative regulation of muscle contraction (GO:0045932) | 3.47875858 |
| 119 | regulation of skeletal muscle cell differentiation (GO:2001014) | 3.45957854 |
| 120 | cell communication involved in cardiac conduction (GO:0086065) | 3.44866356 |
| 121 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.43800876 |
| 122 | cardiac muscle cell action potential (GO:0086001) | 3.42150746 |
| 123 | muscle cell development (GO:0055001) | 3.41661632 |
| 124 | muscle cell cellular homeostasis (GO:0046716) | 3.41101482 |
| 125 | muscle adaptation (GO:0043500) | 3.39554804 |
| 126 | muscle atrophy (GO:0014889) | 3.39463992 |
| 127 | regulation of sequestering of triglyceride (GO:0010889) | 3.38396225 |
| 128 | myotube differentiation (GO:0014902) | 3.38381578 |
| 129 | regulation of ATPase activity (GO:0043462) | 3.36801321 |
| 130 | neuromuscular synaptic transmission (GO:0007274) | 3.34129909 |
| 131 | relaxation of muscle (GO:0090075) | 3.30088086 |
| 132 | striated muscle tissue development (GO:0014706) | 3.30023194 |
| 133 | syncytium formation by plasma membrane fusion (GO:0000768) | 3.24920243 |
| 134 | cellular carbohydrate catabolic process (GO:0044275) | 3.21395716 |
| 135 | ubiquinone biosynthetic process (GO:0006744) | 3.18984867 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.59231845 |
| 2 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.86989359 |
| 3 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.74042020 |
| 4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.64456757 |
| 5 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 3.56719519 |
| 6 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 3.56719519 |
| 7 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.41125182 |
| 8 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 3.29272150 |
| 9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.27530512 |
| 10 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.23408757 |
| 11 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.79965633 |
| 12 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.61979571 |
| 13 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.46570445 |
| 14 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.44338889 |
| 15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.24715830 |
| 16 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.23193600 |
| 17 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.15843534 |
| 18 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 2.08674024 |
| 19 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.78038555 |
| 20 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.77242343 |
| 21 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.74636151 |
| 22 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.69449160 |
| 23 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.67813210 |
| 24 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.66654354 |
| 25 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.57689335 |
| 26 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.54818672 |
| 27 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.52823895 |
| 28 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.50216839 |
| 29 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.48938129 |
| 30 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.48711811 |
| 31 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.48154478 |
| 32 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.45621478 |
| 33 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.44777068 |
| 34 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.43692681 |
| 35 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.42776758 |
| 36 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.42669490 |
| 37 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.40541753 |
| 38 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.38161847 |
| 39 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.31071836 |
| 40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.30766910 |
| 41 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.26372291 |
| 42 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.24581907 |
| 43 | P68_20966046_ChIP-Seq_HELA_Human | 1.23052789 |
| 44 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.20907889 |
| 45 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.18768687 |
| 46 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.18655456 |
| 47 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.17122959 |
| 48 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.16904405 |
| 49 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.15896022 |
| 50 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.14460725 |
| 51 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.13680166 |
| 52 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.12918502 |
| 53 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.12559281 |
| 54 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.12122876 |
| 55 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.11352682 |
| 56 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.10974892 |
| 57 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.09789785 |
| 58 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.09689025 |
| 59 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.08930987 |
| 60 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.07688402 |
| 61 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.06689104 |
| 62 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.04949786 |
| 63 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.04346280 |
| 64 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.03797171 |
| 65 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.03233751 |
| 66 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.02115381 |
| 67 | SA1_27219007_Chip-Seq_Bcells_Human | 1.01620737 |
| 68 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.01288746 |
| 69 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.00889902 |
| 70 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.98416830 |
| 71 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.98320768 |
| 72 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.98118422 |
| 73 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.97385545 |
| 74 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.97083546 |
| 75 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.95931317 |
| 76 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.94877081 |
| 77 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.94708134 |
| 78 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.93024722 |
| 79 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92972208 |
| 80 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.92936590 |
| 81 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.92516700 |
| 82 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.91439839 |
| 83 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.91095041 |
| 84 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.90168972 |
| 85 | KDM2B_26808549_Chip-Seq_K562_Human | 0.89509433 |
| 86 | ATF3_27146783_Chip-Seq_COLON_Human | 0.88265620 |
| 87 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.87929020 |
| 88 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.87874323 |
| 89 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.87747772 |
| 90 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.87469074 |
| 91 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.87330968 |
| 92 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.86708360 |
| 93 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.86708360 |
| 94 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.86691421 |
| 95 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.86483600 |
| 96 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.86126908 |
| 97 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.85902311 |
| 98 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.85768410 |
| 99 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.85727377 |
| 100 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.85306750 |
| 101 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.85236117 |
| 102 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.84368369 |
| 103 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.84342387 |
| 104 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.84247538 |
| 105 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.84033727 |
| 106 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.82681276 |
| 107 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.81280968 |
| 108 | SPI1_23127762_ChIP-Seq_K562_Human | 0.81192207 |
| 109 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.81190955 |
| 110 | GATA1_19941826_ChIP-Seq_K562_Human | 0.81093959 |
| 111 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.80833025 |
| 112 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.80762856 |
| 113 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.80475271 |
| 114 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.80268830 |
| 115 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.80244140 |
| 116 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.78863959 |
| 117 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.78315082 |
| 118 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.78250590 |
| 119 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.77938954 |
| 120 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.77070247 |
| 121 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.76999207 |
| 122 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.76993798 |
| 123 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.76406907 |
| 124 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.76131159 |
| 125 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.76010145 |
| 126 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.75741226 |
| 127 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.75149732 |
| 128 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.75149727 |
| 129 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75070449 |
| 130 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.75011124 |
| 131 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.74746544 |
| 132 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.74524556 |
| 133 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.74516958 |
| 134 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.74091801 |
| 135 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.73157340 |
| 136 | * PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.72832086 |
| 137 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.71554001 |
| 138 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.71454987 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 6.48598146 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 6.01448621 |
| 3 | MP0000751_myopathy | 5.64762612 |
| 4 | MP0000749_muscle_degeneration | 5.09374286 |
| 5 | MP0004145_abnormal_muscle_electrophysio | 4.62180316 |
| 6 | MP0004084_abnormal_cardiac_muscle | 4.41334368 |
| 7 | MP0004036_abnormal_muscle_relaxation | 4.38308203 |
| 8 | MP0004215_abnormal_myocardial_fiber | 3.75161731 |
| 9 | MP0005330_cardiomyopathy | 3.42843138 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.38022293 |
| 11 | MP0002106_abnormal_muscle_physiology | 3.32554286 |
| 12 | MP0004130_abnormal_muscle_cell | 3.07195653 |
| 13 | MP0002269_muscular_atrophy | 3.06215231 |
| 14 | MP0000747_muscle_weakness | 3.03727374 |
| 15 | MP0005620_abnormal_muscle_contractility | 2.96664567 |
| 16 | MP0000750_abnormal_muscle_regeneration | 2.91624760 |
| 17 | MP0000759_abnormal_skeletal_muscle | 2.77889864 |
| 18 | MP0005369_muscle_phenotype | 2.72617954 |
| 19 | MP0002972_abnormal_cardiac_muscle | 2.54042250 |
| 20 | MP0004233_abnormal_muscle_weight | 2.48036016 |
| 21 | MP0003137_abnormal_impulse_conducting | 2.41098481 |
| 22 | MP0010630_abnormal_cardiac_muscle | 2.23587421 |
| 23 | MP0008775_abnormal_heart_ventricle | 2.18420727 |
| 24 | MP0004484_altered_response_of | 2.17392497 |
| 25 | MP0006036_abnormal_mitochondrial_physio | 2.09412456 |
| 26 | MP0005385_cardiovascular_system_phenoty | 2.08980150 |
| 27 | MP0001544_abnormal_cardiovascular_syste | 2.08980150 |
| 28 | MP0003221_abnormal_cardiomyocyte_apopto | 1.94238552 |
| 29 | MP0002332_abnormal_exercise_endurance | 1.89217163 |
| 30 | MP0006138_congestive_heart_failure | 1.64452461 |
| 31 | MP0003828_pulmonary_edema | 1.61481931 |
| 32 | MP0004085_abnormal_heartbeat | 1.54406653 |
| 33 | MP0004510_myositis | 1.47671888 |
| 34 | MP0005666_abnormal_adipose_tissue | 1.43934961 |
| 35 | MP0002108_abnormal_muscle_morphology | 1.34838243 |
| 36 | MP0002127_abnormal_cardiovascular_syste | 1.30080997 |
| 37 | MP0003950_abnormal_plasma_membrane | 1.25559348 |
| 38 | MP0004185_abnormal_adipocyte_glucose | 1.24894549 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.15836774 |
| 40 | MP0000733_abnormal_muscle_development | 1.11162363 |
| 41 | MP0005670_abnormal_white_adipose | 1.06415900 |
| 42 | MP0005375_adipose_tissue_phenotype | 1.04554244 |
| 43 | MP0005266_abnormal_metabolism | 1.03680811 |
| 44 | MP0000013_abnormal_adipose_tissue | 1.02854467 |
| 45 | MP0000343_altered_response_to | 1.02603702 |
| 46 | MP0000266_abnormal_heart_morphology | 0.97418952 |
| 47 | MP0001661_extended_life_span | 0.96343378 |
| 48 | MP0003567_abnormal_fetal_cardiomyocyte | 0.91671126 |
| 49 | MP0002971_abnormal_brown_adipose | 0.85190656 |
| 50 | MP0004043_abnormal_pH_regulation | 0.83553158 |
| 51 | MP0002234_abnormal_pharynx_morphology | 0.80961971 |
| 52 | MP0009780_abnormal_chondrocyte_physiolo | 0.79612003 |
| 53 | MP0003806_abnormal_nucleotide_metabolis | 0.75493089 |
| 54 | MP0003879_abnormal_hair_cell | 0.72744713 |
| 55 | MP0005165_increased_susceptibility_to | 0.70792802 |
| 56 | MP0000003_abnormal_adipose_tissue | 0.67774441 |
| 57 | MP0002909_abnormal_adrenal_gland | 0.67494415 |
| 58 | MP0004147_increased_porphyrin_level | 0.62671250 |
| 59 | MP0000230_abnormal_systemic_arterial | 0.62108737 |
| 60 | MP0004134_abnormal_chest_morphology | 0.61510349 |
| 61 | MP0008961_abnormal_basal_metabolism | 0.61327903 |
| 62 | MP0002078_abnormal_glucose_homeostasis | 0.60879202 |
| 63 | MP0000372_irregular_coat_pigmentation | 0.58506341 |
| 64 | MP0001299_abnormal_eye_distance/ | 0.55868304 |
| 65 | MP0002128_abnormal_blood_circulation | 0.52602224 |
| 66 | MP0005423_abnormal_somatic_nervous | 0.51249808 |
| 67 | MP0003279_aneurysm | 0.50276858 |
| 68 | MP0002822_catalepsy | 0.47410144 |
| 69 | MP0002734_abnormal_mechanical_nocicepti | 0.46328621 |
| 70 | MP0008569_lethality_at_weaning | 0.46139777 |
| 71 | MP0001346_abnormal_lacrimal_gland | 0.45371935 |
| 72 | MP0003705_abnormal_hypodermis_morpholog | 0.45000203 |
| 73 | MP0009672_abnormal_birth_weight | 0.43576879 |
| 74 | MP0010030_abnormal_orbit_morphology | 0.42653416 |
| 75 | MP0005334_abnormal_fat_pad | 0.42101915 |
| 76 | MP0003656_abnormal_erythrocyte_physiolo | 0.41703267 |
| 77 | MP0004270_analgesia | 0.41598697 |
| 78 | MP0005167_abnormal_blood-brain_barrier | 0.41582634 |
| 79 | MP0010368_abnormal_lymphatic_system | 0.40628232 |
| 80 | MP0005451_abnormal_body_composition | 0.39700909 |
| 81 | MP0002638_abnormal_pupillary_reflex | 0.39133916 |
| 82 | MP0005319_abnormal_enzyme/_coenzyme | 0.38489672 |
| 83 | MP0005535_abnormal_body_temperature | 0.38086518 |
| 84 | MP0005166_decreased_susceptibility_to | 0.37925017 |
| 85 | MP0002114_abnormal_axial_skeleton | 0.37853844 |
| 86 | MP0003045_fibrosis | 0.35346157 |
| 87 | MP0005623_abnormal_meninges_morphology | 0.35273361 |
| 88 | MP0009250_abnormal_appendicular_skeleto | 0.32908858 |
| 89 | MP0005452_abnormal_adipose_tissue | 0.31388435 |
| 90 | MP0003948_abnormal_gas_homeostasis | 0.31335389 |
| 91 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.30363081 |
| 92 | MP0004924_abnormal_behavior | 0.30291075 |
| 93 | MP0005386_behavior/neurological_phenoty | 0.30291075 |
| 94 | MP0009115_abnormal_fat_cell | 0.28129654 |
| 95 | MP0002896_abnormal_bone_mineralization | 0.27695587 |
| 96 | MP0002925_abnormal_cardiovascular_devel | 0.27662818 |
| 97 | MP0003566_abnormal_cell_adhesion | 0.27589391 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.27555790 |
| 99 | MP0001943_abnormal_respiration | 0.26890307 |
| 100 | MP0001879_abnormal_lymphatic_vessel | 0.26747617 |
| 101 | MP0003959_abnormal_lean_body | 0.25383160 |
| 102 | MP0002249_abnormal_larynx_morphology | 0.24938215 |
| 103 | MP0002067_abnormal_sensory_capabilities | 0.24329377 |
| 104 | MP0005083_abnormal_biliary_tract | 0.24078978 |
| 105 | MP0004142_abnormal_muscle_tone | 0.23632258 |
| 106 | MP0005187_abnormal_penis_morphology | 0.23030939 |
| 107 | MP0004858_abnormal_nervous_system | 0.22934695 |
| 108 | MP0005376_homeostasis/metabolism_phenot | 0.22901392 |
| 109 | MP0000767_abnormal_smooth_muscle | 0.22469380 |
| 110 | MP0008874_decreased_physiological_sensi | 0.22095791 |
| 111 | MP0002118_abnormal_lipid_homeostasis | 0.21916040 |
| 112 | MP0005332_abnormal_amino_acid | 0.21604901 |
| 113 | MP0001784_abnormal_fluid_regulation | 0.21257307 |
| 114 | MP0005058_abnormal_lysosome_morphology | 0.20275448 |
| 115 | MP0002970_abnormal_white_adipose | 0.19743380 |
| 116 | MP0006072_abnormal_retinal_apoptosis | 0.18420956 |
| 117 | MP0004859_abnormal_synaptic_plasticity | 0.16997166 |
| 118 | MP0002066_abnormal_motor_capabilities/c | 0.16959188 |
| 119 | MP0001440_abnormal_grooming_behavior | 0.16818437 |
| 120 | MP0001614_abnormal_blood_vessel | 0.16435022 |
| 121 | MP0003984_embryonic_growth_retardation | 0.16302929 |
| 122 | MP0003633_abnormal_nervous_system | 0.16049216 |
| 123 | MP0002088_abnormal_embryonic_growth/wei | 0.14656984 |
| 124 | MP0000762_abnormal_tongue_morphology | 0.13792916 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 8.04982536 |
| 2 | Exercise-induced muscle cramps (HP:0003710) | 7.60181345 |
| 3 | Muscle hypertrophy of the lower extremities (HP:0008968) | 7.21912000 |
| 4 | Calf muscle hypertrophy (HP:0008981) | 7.12415751 |
| 5 | Muscle fiber inclusion bodies (HP:0100299) | 6.26640821 |
| 6 | Sudden death (HP:0001699) | 6.11561881 |
| 7 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 5.99376304 |
| 8 | Muscle fiber splitting (HP:0003555) | 5.70034854 |
| 9 | Myoglobinuria (HP:0002913) | 5.64253404 |
| 10 | Nemaline bodies (HP:0003798) | 5.35978912 |
| 11 | Hyporeflexia of lower limbs (HP:0002600) | 5.24594812 |
| 12 | Abnormality of the calf musculature (HP:0001430) | 5.18316684 |
| 13 | Ventricular tachycardia (HP:0004756) | 5.01997345 |
| 14 | Type 1 muscle fiber predominance (HP:0003803) | 4.77947806 |
| 15 | EMG: myopathic abnormalities (HP:0003458) | 4.73998111 |
| 16 | Difficulty running (HP:0009046) | 4.71635231 |
| 17 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.62527947 |
| 18 | Subaortic stenosis (HP:0001682) | 4.62527947 |
| 19 | Rhabdomyolysis (HP:0003201) | 4.46558748 |
| 20 | Increased connective tissue (HP:0009025) | 4.19265086 |
| 21 | Myotonia (HP:0002486) | 4.18211075 |
| 22 | Asymmetric septal hypertrophy (HP:0001670) | 4.15684073 |
| 23 | Atrial fibrillation (HP:0005110) | 4.09895102 |
| 24 | Muscle stiffness (HP:0003552) | 4.06142753 |
| 25 | Distal arthrogryposis (HP:0005684) | 3.88499873 |
| 26 | Lipoatrophy (HP:0100578) | 3.85726167 |
| 27 | Primary atrial arrhythmia (HP:0001692) | 3.83281057 |
| 28 | Myopathic facies (HP:0002058) | 3.80362613 |
| 29 | Supraventricular tachycardia (HP:0004755) | 3.69715023 |
| 30 | Supraventricular arrhythmia (HP:0005115) | 3.60380121 |
| 31 | Bundle branch block (HP:0011710) | 3.56869580 |
| 32 | Round ear (HP:0100830) | 3.46557940 |
| 33 | Difficulty climbing stairs (HP:0003551) | 3.40578172 |
| 34 | Palpitations (HP:0001962) | 3.39815913 |
| 35 | Dilated cardiomyopathy (HP:0001644) | 3.33852836 |
| 36 | Areflexia of lower limbs (HP:0002522) | 3.19564244 |
| 37 | Right ventricular cardiomyopathy (HP:0011663) | 3.18631657 |
| 38 | Neck muscle weakness (HP:0000467) | 3.17160887 |
| 39 | Syncope (HP:0001279) | 3.09456306 |
| 40 | Prolonged QT interval (HP:0001657) | 3.07318700 |
| 41 | Ulnar deviation of the wrist (HP:0003049) | 3.07165486 |
| 42 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.05985143 |
| 43 | Ventricular arrhythmia (HP:0004308) | 2.99947198 |
| 44 | Increased variability in muscle fiber diameter (HP:0003557) | 2.97263907 |
| 45 | Rimmed vacuoles (HP:0003805) | 2.94852658 |
| 46 | Heart block (HP:0012722) | 2.94670980 |
| 47 | Distal lower limb muscle weakness (HP:0009053) | 2.83501821 |
| 48 | Abnormal atrioventricular conduction (HP:0005150) | 2.75448773 |
| 49 | Fetal akinesia sequence (HP:0001989) | 2.70502621 |
| 50 | Atrioventricular block (HP:0001678) | 2.60220173 |
| 51 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.55727204 |
| 52 | Slender build (HP:0001533) | 2.55571627 |
| 53 | Ventricular fibrillation (HP:0001663) | 2.55539232 |
| 54 | Calcaneovalgus deformity (HP:0001848) | 2.51980097 |
| 55 | Acute necrotizing encephalopathy (HP:0006965) | 2.50623505 |
| 56 | Abnormality of the calcaneus (HP:0008364) | 2.49951339 |
| 57 | Weak cry (HP:0001612) | 2.48707877 |
| 58 | EMG: neuropathic changes (HP:0003445) | 2.48549118 |
| 59 | Scapular winging (HP:0003691) | 2.48159105 |
| 60 | Left ventricular hypertrophy (HP:0001712) | 2.43015439 |
| 61 | Ketoacidosis (HP:0001993) | 2.39002323 |
| 62 | Abnormal EKG (HP:0003115) | 2.35596414 |
| 63 | Spinal rigidity (HP:0003306) | 2.33918600 |
| 64 | Limb-girdle muscle atrophy (HP:0003797) | 2.32652446 |
| 65 | Absent phalangeal crease (HP:0006109) | 2.31592390 |
| 66 | Hepatic necrosis (HP:0002605) | 2.31105752 |
| 67 | Frequent falls (HP:0002359) | 2.30999364 |
| 68 | Muscular dystrophy (HP:0003560) | 2.29803257 |
| 69 | Hypoplastic ischia (HP:0003175) | 2.27471508 |
| 70 | Hip contracture (HP:0003273) | 2.25918444 |
| 71 | Deformed tarsal bones (HP:0008119) | 2.24169077 |
| 72 | Abnormality of alanine metabolism (HP:0010916) | 2.22773113 |
| 73 | Hyperalaninemia (HP:0003348) | 2.22773113 |
| 74 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.22773113 |
| 75 | Progressive muscle weakness (HP:0003323) | 2.21573547 |
| 76 | Acute encephalopathy (HP:0006846) | 2.18082144 |
| 77 | Gowers sign (HP:0003391) | 2.15339798 |
| 78 | Generalized muscle weakness (HP:0003324) | 2.15233741 |
| 79 | Exercise intolerance (HP:0003546) | 2.11905647 |
| 80 | Proximal amyotrophy (HP:0007126) | 2.10269424 |
| 81 | Hepatocellular necrosis (HP:0001404) | 2.07903248 |
| 82 | Distal lower limb amyotrophy (HP:0008944) | 2.07451304 |
| 83 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.07078236 |
| 84 | Progressive macrocephaly (HP:0004481) | 2.06974131 |
| 85 | Facial diplegia (HP:0001349) | 2.06563528 |
| 86 | Waddling gait (HP:0002515) | 2.04508697 |
| 87 | Malignant hyperthermia (HP:0002047) | 2.01629034 |
| 88 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.00680130 |
| 89 | Lower limb amyotrophy (HP:0007210) | 2.00185823 |
| 90 | Increased muscle lipid content (HP:0009058) | 1.99340094 |
| 91 | Pheochromocytoma (HP:0002666) | 1.98963413 |
| 92 | Hyperkalemia (HP:0002153) | 1.98672308 |
| 93 | Mitochondrial inheritance (HP:0001427) | 1.97828044 |
| 94 | Testicular atrophy (HP:0000029) | 1.96999689 |
| 95 | Abnormality of the ischium (HP:0003174) | 1.96839339 |
| 96 | Abnormality of the neuromuscular junction (HP:0003398) | 1.94704296 |
| 97 | Fatigable weakness (HP:0003473) | 1.94704296 |
| 98 | Bulbar palsy (HP:0001283) | 1.94667427 |
| 99 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.91989881 |
| 100 | Large for gestational age (HP:0001520) | 1.91755048 |
| 101 | Neuroendocrine neoplasm (HP:0100634) | 1.91364437 |
| 102 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.91220444 |
| 103 | Limb-girdle muscle weakness (HP:0003325) | 1.89940307 |
| 104 | Palmoplantar keratoderma (HP:0000982) | 1.89617190 |
| 105 | Increased CSF lactate (HP:0002490) | 1.88868015 |
| 106 | Abnormal finger flexion creases (HP:0006143) | 1.87861715 |
| 107 | Conjunctival hamartoma (HP:0100780) | 1.84013675 |
| 108 | Abnormality of the foot musculature (HP:0001436) | 1.83908199 |
| 109 | Foot dorsiflexor weakness (HP:0009027) | 1.83480576 |
| 110 | Cerebral edema (HP:0002181) | 1.83006210 |
| 111 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.82897538 |
| 112 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.82897538 |
| 113 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.82819723 |
| 114 | Metatarsus adductus (HP:0001840) | 1.81078083 |
| 115 | Long clavicles (HP:0000890) | 1.80578971 |
| 116 | Shoulder girdle muscle weakness (HP:0003547) | 1.79417780 |
| 117 | Pelvic girdle muscle weakness (HP:0003749) | 1.77967523 |
| 118 | Ragged-red muscle fibers (HP:0003200) | 1.75439674 |
| 119 | Popliteal pterygium (HP:0009756) | 1.74230952 |
| 120 | Nonprogressive disorder (HP:0003680) | 1.67744731 |
| 121 | Paralysis (HP:0003470) | 1.67527012 |
| 122 | Ulnar deviation of finger (HP:0009465) | 1.63160502 |
| 123 | Limited hip movement (HP:0008800) | 1.51165143 |
| 124 | Type 2 muscle fiber atrophy (HP:0003554) | 1.50937870 |
| 125 | Increased intramyocellular lipid droplets (HP:0012240) | 1.48569691 |
| 126 | Muscle fiber atrophy (HP:0100295) | 1.40903892 |
| 127 | Ulnar deviation of the hand or of fingers of the hand (HP:0001193) | 1.35878408 |
| 128 | Steppage gait (HP:0003376) | 1.35255857 |
| 129 | Oligomenorrhea (HP:0000876) | 1.28955352 |
| 130 | Adducted thumb (HP:0001181) | 1.27835256 |
| 131 | Congenital hip dislocation (HP:0001374) | 1.27545996 |
| 132 | Amniotic constriction ring (HP:0009775) | 1.24530326 |
| 133 | Abnormality of placental membranes (HP:0011409) | 1.24530326 |
| 134 | Easy fatigability (HP:0003388) | 1.22500877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 6.73196493 |
| 2 | TTN | 6.33390227 |
| 3 | PHKG2 | 5.18391999 |
| 4 | PHKG1 | 5.18391999 |
| 5 | PDK4 | 3.06022078 |
| 6 | PDK3 | 3.06022078 |
| 7 | PINK1 | 2.96741225 |
| 8 | NEK1 | 2.71821420 |
| 9 | DMPK | 2.49691710 |
| 10 | LMTK2 | 2.28947391 |
| 11 | BCKDK | 2.25563131 |
| 12 | TRIB3 | 2.11912403 |
| 13 | NME1 | 2.00476541 |
| 14 | MYLK | 1.92554710 |
| 15 | MAP2K3 | 1.87601949 |
| 16 | MUSK | 1.86850641 |
| 17 | PIK3CG | 1.85178307 |
| 18 | PDK2 | 1.84207820 |
| 19 | PKN2 | 1.82976513 |
| 20 | PIK3CA | 1.79634781 |
| 21 | MAP3K7 | 1.52125269 |
| 22 | STK24 | 1.33407637 |
| 23 | EEF2K | 1.25844743 |
| 24 | MAPK12 | 1.24082917 |
| 25 | MARK1 | 1.19617642 |
| 26 | PRKAA1 | 1.08487262 |
| 27 | ICK | 1.04513003 |
| 28 | TIE1 | 1.03714825 |
| 29 | MAP2K4 | 0.98097777 |
| 30 | CCNB1 | 0.98006088 |
| 31 | MOS | 0.94740714 |
| 32 | MAP3K6 | 0.92177351 |
| 33 | TRPM7 | 0.91491307 |
| 34 | LIMK1 | 0.90834581 |
| 35 | MAPKAPK3 | 0.90688651 |
| 36 | PRKAA2 | 0.89870354 |
| 37 | CAMK2D | 0.87521169 |
| 38 | MAP3K11 | 0.85404455 |
| 39 | GRK7 | 0.83516189 |
| 40 | PRKD1 | 0.83266241 |
| 41 | RIPK1 | 0.79945954 |
| 42 | MAP3K13 | 0.74912511 |
| 43 | PAK3 | 0.70412964 |
| 44 | MAP2K6 | 0.70093730 |
| 45 | ZAK | 0.67701250 |
| 46 | MAP3K5 | 0.64021689 |
| 47 | ILK | 0.63470668 |
| 48 | CDC42BPA | 0.60745736 |
| 49 | PKN1 | 0.60572873 |
| 50 | STK38 | 0.58841397 |
| 51 | MAP3K3 | 0.58096800 |
| 52 | STK38L | 0.58054817 |
| 53 | MAPK7 | 0.57948785 |
| 54 | NEK9 | 0.55322924 |
| 55 | MAPK15 | 0.52678708 |
| 56 | ROCK1 | 0.51619219 |
| 57 | FLT3 | 0.51178077 |
| 58 | CAMK2G | 0.50413898 |
| 59 | MAPK11 | 0.50131798 |
| 60 | PDGFRA | 0.50097431 |
| 61 | RPS6KL1 | 0.47781847 |
| 62 | RPS6KC1 | 0.47781847 |
| 63 | MAP2K1 | 0.45871158 |
| 64 | CAMK2B | 0.45557422 |
| 65 | TAOK1 | 0.44550755 |
| 66 | CAMK2A | 0.41385129 |
| 67 | CAMK4 | 0.40955463 |
| 68 | PRKACB | 0.40737483 |
| 69 | AKT2 | 0.40142124 |
| 70 | TAOK2 | 0.37677396 |
| 71 | RPS6KA6 | 0.37423194 |
| 72 | INSRR | 0.35622923 |
| 73 | LATS2 | 0.35424586 |
| 74 | SGK2 | 0.33604660 |
| 75 | MAPK13 | 0.33300010 |
| 76 | PDPK1 | 0.32694524 |
| 77 | ARAF | 0.32683130 |
| 78 | PRKACA | 0.32274443 |
| 79 | CAMK1 | 0.31786599 |
| 80 | RPS6KB1 | 0.30490072 |
| 81 | SGK1 | 0.29528685 |
| 82 | WNK1 | 0.29161849 |
| 83 | PDK1 | 0.29098831 |
| 84 | DAPK2 | 0.29096744 |
| 85 | STK4 | 0.28673971 |
| 86 | PRPF4B | 0.28400350 |
| 87 | MAP3K1 | 0.28217164 |
| 88 | PAK6 | 0.27392058 |
| 89 | DDR2 | 0.27292312 |
| 90 | RPS6KA1 | 0.27059883 |
| 91 | MARK2 | 0.26803645 |
| 92 | PRKACG | 0.26585735 |
| 93 | EPHB1 | 0.25780179 |
| 94 | MAPK10 | 0.25558772 |
| 95 | RPS6KA3 | 0.25100724 |
| 96 | CDK19 | 0.25055660 |
| 97 | ROCK2 | 0.23779069 |
| 98 | SIK1 | 0.23703422 |
| 99 | MAP3K10 | 0.22300980 |
| 100 | KSR2 | 0.22184864 |
| 101 | MAP3K4 | 0.22136043 |
| 102 | TBK1 | 0.21872277 |
| 103 | WNK4 | 0.21088842 |
| 104 | RPS6KB2 | 0.20922187 |
| 105 | MAP3K9 | 0.20867722 |
| 106 | TGFBR2 | 0.20746269 |
| 107 | DAPK3 | 0.20235294 |
| 108 | PRKD3 | 0.18691240 |
| 109 | SGK494 | 0.18614975 |
| 110 | SGK223 | 0.18614975 |
| 111 | PRKG1 | 0.17698690 |
| 112 | UHMK1 | 0.17542486 |
| 113 | PRKD2 | 0.15931452 |
| 114 | PTK6 | 0.15509865 |
| 115 | MARK3 | 0.13365756 |
| 116 | DYRK1B | 0.12798836 |
| 117 | RAF1 | 0.12755300 |
| 118 | PRKCH | 0.12661531 |
| 119 | NME2 | 0.12379727 |
| 120 | MAPK4 | 0.12345487 |
| 121 | MTOR | 0.12313562 |
| 122 | BRAF | 0.11850361 |
| 123 | RPS6KA2 | 0.11821975 |
| 124 | SGK3 | 0.11591494 |
| 125 | ERBB3 | 0.11377388 |
| 126 | PTK2B | 0.08603433 |
| 127 | LATS1 | 0.07616750 |
| 128 | STK11 | 0.07136761 |
| 129 | KSR1 | 0.05757588 |
| 130 | TNK2 | 0.05646214 |
| 131 | MAPK9 | 0.04276674 |
| 132 | GSK3B | 0.04011522 |
| 133 | MAPK8 | 0.03709468 |
| 134 | CDK5 | 0.02152345 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.70330330 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.27988520 |
| 3 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.25594177 |
| 4 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.76193048 |
| 5 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.60821314 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.04193648 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.00595678 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.89048264 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.86481250 |
| 10 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.67757588 |
| 11 | Carbon metabolism_Homo sapiens_hsa01200 | 2.40945915 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.28991794 |
| 13 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.20222420 |
| 14 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.04971298 |
| 15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.02747466 |
| 16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.86623207 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.86167058 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.77005495 |
| 19 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.72327934 |
| 20 | Viral myocarditis_Homo sapiens_hsa05416 | 1.53915878 |
| 21 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.49678149 |
| 22 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.49190532 |
| 23 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.47299497 |
| 24 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.40568137 |
| 25 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.38624047 |
| 26 | Circadian rhythm_Homo sapiens_hsa04710 | 1.33005460 |
| 27 | Insulin resistance_Homo sapiens_hsa04931 | 1.29862002 |
| 28 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.23157361 |
| 29 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.17159784 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.13216699 |
| 31 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.12257872 |
| 32 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.11533812 |
| 33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.11105432 |
| 34 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.07070429 |
| 35 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.05927828 |
| 36 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.04590309 |
| 37 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.02196826 |
| 38 | Galactose metabolism_Homo sapiens_hsa00052 | 0.97794417 |
| 39 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.96015077 |
| 40 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.95782822 |
| 41 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.91580951 |
| 42 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.80590148 |
| 43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77241359 |
| 44 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.72852641 |
| 45 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.72146082 |
| 46 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.70779392 |
| 47 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.70159834 |
| 48 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.70149706 |
| 49 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.65772860 |
| 50 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.65743889 |
| 51 | Insulin secretion_Homo sapiens_hsa04911 | 0.64858153 |
| 52 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.62870948 |
| 53 | Tight junction_Homo sapiens_hsa04530 | 0.62839900 |
| 54 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.60980246 |
| 55 | Focal adhesion_Homo sapiens_hsa04510 | 0.59812521 |
| 56 | Renin secretion_Homo sapiens_hsa04924 | 0.59426624 |
| 57 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57887973 |
| 58 | Lysine degradation_Homo sapiens_hsa00310 | 0.50082162 |
| 59 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.49742505 |
| 60 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.49431702 |
| 61 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.48478868 |
| 62 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.48395141 |
| 63 | Long-term depression_Homo sapiens_hsa04730 | 0.47493166 |
| 64 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.46671527 |
| 65 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.45546578 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.44369918 |
| 67 | Circadian entrainment_Homo sapiens_hsa04713 | 0.43205700 |
| 68 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.39422576 |
| 69 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.36090356 |
| 70 | Glioma_Homo sapiens_hsa05214 | 0.36009055 |
| 71 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.33518225 |
| 72 | Olfactory transduction_Homo sapiens_hsa04740 | 0.30749371 |
| 73 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.30478924 |
| 74 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.29684478 |
| 75 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.28794939 |
| 76 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.28526211 |
| 77 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.28150157 |
| 78 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.27431631 |
| 79 | Melanogenesis_Homo sapiens_hsa04916 | 0.26487848 |
| 80 | Adherens junction_Homo sapiens_hsa04520 | 0.26326329 |
| 81 | Peroxisome_Homo sapiens_hsa04146 | 0.25741950 |
| 82 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.25605821 |
| 83 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.25585011 |
| 84 | Histidine metabolism_Homo sapiens_hsa00340 | 0.24934549 |
| 85 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.24320665 |
| 86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23042351 |
| 87 | Gap junction_Homo sapiens_hsa04540 | 0.22420330 |
| 88 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.20722927 |
| 89 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.20716940 |
| 90 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.20488387 |
| 91 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.20361431 |
| 92 | Metabolic pathways_Homo sapiens_hsa01100 | 0.19120729 |
| 93 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.19083473 |
| 94 | Platelet activation_Homo sapiens_hsa04611 | 0.18788535 |
| 95 | Long-term potentiation_Homo sapiens_hsa04720 | 0.18089534 |
| 96 | GABAergic synapse_Homo sapiens_hsa04727 | 0.17896517 |
| 97 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.17223781 |
| 98 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.16979946 |
| 99 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.15480092 |
| 100 | Purine metabolism_Homo sapiens_hsa00230 | 0.15200205 |
| 101 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.15039067 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.14611980 |
| 103 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.14551470 |
| 104 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.14399534 |
| 105 | Taste transduction_Homo sapiens_hsa04742 | 0.14306035 |
| 106 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.14015296 |
| 107 | Thyroid cancer_Homo sapiens_hsa05216 | 0.13961947 |
| 108 | Bile secretion_Homo sapiens_hsa04976 | 0.11194671 |
| 109 | Morphine addiction_Homo sapiens_hsa05032 | 0.11063192 |
| 110 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.09855016 |
| 111 | Amoebiasis_Homo sapiens_hsa05146 | 0.09509810 |
| 112 | Salivary secretion_Homo sapiens_hsa04970 | 0.07815206 |
| 113 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.07496895 |
| 114 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.07150254 |
| 115 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.05484639 |
| 116 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.04201146 |
| 117 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.03368563 |
| 118 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.01035780 |

