MYADML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)9.11058974
2muscle filament sliding (GO:0030049)9.11058974
3sarcomere organization (GO:0045214)8.60694537
4regulation of skeletal muscle contraction (GO:0014819)8.21871609
5actin-mediated cell contraction (GO:0070252)7.43830920
6myofibril assembly (GO:0030239)7.41439447
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.36670913
8sarcoplasmic reticulum calcium ion transport (GO:0070296)7.18561972
9cardiac myofibril assembly (GO:0055003)7.14297702
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.10461911
11skeletal muscle fiber development (GO:0048741)6.97892373
12plasma membrane repair (GO:0001778)6.86010003
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.72989823
14skeletal muscle contraction (GO:0003009)6.54542271
15negative regulation of potassium ion transmembrane transport (GO:1901380)6.28078972
16myotube cell development (GO:0014904)6.26582439
17cardiac muscle contraction (GO:0060048)6.23116263
18striated muscle contraction (GO:0006941)6.13648232
19tricarboxylic acid cycle (GO:0006099)6.12836151
20carnitine shuttle (GO:0006853)5.97092111
21regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.86363455
22regulation of cell communication by electrical coupling (GO:0010649)5.84180976
23regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.82104175
24regulation of relaxation of muscle (GO:1901077)5.81914054
25actin filament-based movement (GO:0030048)5.59502593
26actomyosin structure organization (GO:0031032)5.54155025
27cardiac muscle cell development (GO:0055013)5.42494821
28skeletal muscle adaptation (GO:0043501)5.41534951
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.40777021
30regulation of actin filament-based movement (GO:1903115)5.33943594
31regulation of acyl-CoA biosynthetic process (GO:0050812)5.33044985
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.25416485
33fatty acid transmembrane transport (GO:1902001)5.06420641
34cardiac cell development (GO:0055006)5.06101006
35response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.05305088
36creatine metabolic process (GO:0006600)5.01518761
37regulation of coenzyme metabolic process (GO:0051196)4.89210506
38regulation of cofactor metabolic process (GO:0051193)4.89210506
39skeletal muscle tissue development (GO:0007519)4.86641987
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.78191371
41cardiac muscle hypertrophy (GO:0003300)4.76059356
42heart process (GO:0003015)4.75816505
43heart contraction (GO:0060047)4.75816505
44striated muscle hypertrophy (GO:0014897)4.65113051
45cardiac muscle tissue morphogenesis (GO:0055008)4.62210433
46regulation of striated muscle contraction (GO:0006942)4.57347135
47skeletal muscle tissue regeneration (GO:0043403)4.56549401
48glycogen catabolic process (GO:0005980)4.49782296
49regulation of sarcomere organization (GO:0060297)4.47627567
50adult heart development (GO:0007512)4.41586607
51muscle contraction (GO:0006936)4.40141495
52carnitine transmembrane transport (GO:1902603)4.37631890
53ventricular cardiac muscle cell action potential (GO:0086005)4.34805434
54regulation of membrane repolarization (GO:0060306)4.34287935
55muscle tissue morphogenesis (GO:0060415)4.27439577
56positive regulation of myotube differentiation (GO:0010831)4.26283586
57fructose metabolic process (GO:0006000)4.25294580
58response to inactivity (GO:0014854)4.18765608
59glucan catabolic process (GO:0009251)4.18638349
60muscle organ morphogenesis (GO:0048644)4.17620954
61striated muscle adaptation (GO:0014888)4.13783220
62glycogen metabolic process (GO:0005977)4.09134421
63pyrimidine ribonucleoside catabolic process (GO:0046133)4.08444636
64muscle hypertrophy (GO:0014896)4.08106984
65oxidative phosphorylation (GO:0006119)4.05485073
66muscle organ development (GO:0007517)4.03681799
67muscle structure development (GO:0061061)4.03279152
68heart trabecula formation (GO:0060347)4.03121471
69positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.02172751
70muscle system process (GO:0003012)4.01800636
71muscle cell fate commitment (GO:0042693)4.01517386
72cellular glucan metabolic process (GO:0006073)4.01072334
73glucan metabolic process (GO:0044042)4.01072334
74carnitine transport (GO:0015879)3.96294099
75amino-acid betaine transport (GO:0015838)3.96294099
76gluconeogenesis (GO:0006094)3.95578553
77NADH metabolic process (GO:0006734)3.95500809
78response to muscle activity (GO:0014850)3.94641931
79ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.92537294
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.90331605
81response to activity (GO:0014823)3.89538721
82cellular polysaccharide catabolic process (GO:0044247)3.89419194
83regulation of sulfur metabolic process (GO:0042762)3.87961016
84striated muscle cell development (GO:0055002)3.83419421
85regulation of calcium ion transmembrane transport (GO:1903169)3.82867268
86regulation of calcium ion transmembrane transporter activity (GO:1901019)3.82867268
87cytidine deamination (GO:0009972)3.79928471
88cytidine metabolic process (GO:0046087)3.79928471
89cytidine catabolic process (GO:0006216)3.79928471
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79476848
91striated muscle atrophy (GO:0014891)3.79292509
92neuronal action potential propagation (GO:0019227)3.77717876
93respiratory electron transport chain (GO:0022904)3.72864260
94myoblast fusion (GO:0007520)3.71049564
952-oxoglutarate metabolic process (GO:0006103)3.68458225
96muscle fiber development (GO:0048747)3.67783748
97polysaccharide catabolic process (GO:0000272)3.66155150
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65213295
99electron transport chain (GO:0022900)3.61895014
100muscle hypertrophy in response to stress (GO:0003299)3.58365018
101cardiac muscle adaptation (GO:0014887)3.58365018
102cardiac muscle hypertrophy in response to stress (GO:0014898)3.58365018
103negative regulation of calcium ion transmembrane transport (GO:1903170)3.56865620
104negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.56865620
105bundle of His cell to Purkinje myocyte communication (GO:0086069)3.54142776
106hexose biosynthetic process (GO:0019319)3.54128444
107regulation of the force of heart contraction (GO:0002026)3.53118026
108ATP synthesis coupled proton transport (GO:0015986)3.52356101
109energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52356101
110positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.52054690
111IMP metabolic process (GO:0046040)3.51723265
112regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.51148901
113negative regulation of potassium ion transport (GO:0043267)3.50202737
114positive regulation of cation channel activity (GO:2001259)3.49865665
115glycogen biosynthetic process (GO:0005978)3.49136270
116glucan biosynthetic process (GO:0009250)3.49136270
117regulation of myoblast differentiation (GO:0045661)3.49113699
118negative regulation of muscle contraction (GO:0045932)3.47875858
119regulation of skeletal muscle cell differentiation (GO:2001014)3.45957854
120cell communication involved in cardiac conduction (GO:0086065)3.44866356
121cardiac muscle cell action potential involved in contraction (GO:0086002)3.43800876
122cardiac muscle cell action potential (GO:0086001)3.42150746
123muscle cell development (GO:0055001)3.41661632
124muscle cell cellular homeostasis (GO:0046716)3.41101482
125muscle adaptation (GO:0043500)3.39554804
126muscle atrophy (GO:0014889)3.39463992
127regulation of sequestering of triglyceride (GO:0010889)3.38396225
128myotube differentiation (GO:0014902)3.38381578
129regulation of ATPase activity (GO:0043462)3.36801321
130neuromuscular synaptic transmission (GO:0007274)3.34129909
131relaxation of muscle (GO:0090075)3.30088086
132striated muscle tissue development (GO:0014706)3.30023194
133syncytium formation by plasma membrane fusion (GO:0000768)3.24920243
134cellular carbohydrate catabolic process (GO:0044275)3.21395716
135ubiquinone biosynthetic process (GO:0006744)3.18984867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.59231845
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.86989359
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.74042020
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.64456757
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.56719519
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.56719519
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41125182
8EP300_21415370_ChIP-Seq_HL-1_Mouse3.29272150
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.27530512
10ZNF263_19887448_ChIP-Seq_K562_Human3.23408757
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.79965633
12EZH2_22144423_ChIP-Seq_EOC_Human2.61979571
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.46570445
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.44338889
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24715830
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23193600
17GATA4_21415370_ChIP-Seq_HL-1_Mouse2.15843534
18BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.08674024
19CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.78038555
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77242343
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74636151
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69449160
23CTCF_27219007_Chip-Seq_Bcells_Human1.67813210
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66654354
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57689335
26NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.54818672
27LXR_22292898_ChIP-Seq_THP-1_Human1.52823895
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50216839
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48938129
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48711811
31KDM2B_26808549_Chip-Seq_DND41_Human1.48154478
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45621478
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.44777068
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43692681
35DROSHA_22980978_ChIP-Seq_HELA_Human1.42776758
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42669490
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40541753
38CTCF_21964334_ChIP-Seq_BJAB-B_Human1.38161847
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31071836
40ZNF274_21170338_ChIP-Seq_K562_Hela1.30766910
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26372291
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.24581907
43P68_20966046_ChIP-Seq_HELA_Human1.23052789
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20907889
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.18768687
46STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18655456
47TP63_22573176_ChIP-Seq_HFKS_Human1.17122959
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16904405
49OCT4_20526341_ChIP-Seq_ESCs_Human1.15896022
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14460725
51SPI1_20517297_ChIP-Seq_HL60_Human1.13680166
52FOXH1_21741376_ChIP-Seq_ESCs_Human1.12918502
53RACK7_27058665_Chip-Seq_MCF-7_Human1.12559281
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12122876
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11352682
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10974892
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09789785
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09689025
59BCL6_27268052_Chip-Seq_Bcells_Human1.08930987
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07688402
61IGF1R_20145208_ChIP-Seq_DFB_Human1.06689104
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04949786
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04346280
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03797171
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.03233751
66BCOR_27268052_Chip-Seq_Bcells_Human1.02115381
67SA1_27219007_Chip-Seq_Bcells_Human1.01620737
68CTCF_21964334_Chip-Seq_Bcells_Human1.01288746
69E2F1_20622854_ChIP-Seq_HELA_Human1.00889902
70ERG_21242973_ChIP-ChIP_JURKAT_Human0.98416830
71JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98320768
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98118422
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97385545
74SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97083546
75CLOCK_20551151_ChIP-Seq_293T_Human0.95931317
76EZH2_27304074_Chip-Seq_ESCs_Mouse0.94877081
77CREB1_26743006_Chip-Seq_LNCaP_Human0.94708134
78TP53_23651856_ChIP-Seq_MEFs_Mouse0.93024722
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92972208
80PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92936590
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92516700
82RUNX1_27514584_Chip-Seq_MCF-7_Human0.91439839
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91095041
84P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90168972
85KDM2B_26808549_Chip-Seq_K562_Human0.89509433
86ATF3_27146783_Chip-Seq_COLON_Human0.88265620
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.87929020
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87874323
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.87747772
90SMC4_20622854_ChIP-Seq_HELA_Human0.87469074
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87330968
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86708360
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86708360
94MYC_27129775_Chip-Seq_CORNEA_Mouse0.86691421
95TCF7_22412390_ChIP-Seq_EML_Mouse0.86483600
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86126908
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85902311
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.85768410
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85727377
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.85306750
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.85236117
102RXR_22158963_ChIP-Seq_LIVER_Mouse0.84368369
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84342387
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84247538
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84033727
106DPY_21335234_ChIP-Seq_ESCs_Mouse0.82681276
107OCT4_19829295_ChIP-Seq_ESCs_Human0.81280968
108SPI1_23127762_ChIP-Seq_K562_Human0.81192207
109TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81190955
110GATA1_19941826_ChIP-Seq_K562_Human0.81093959
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80833025
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80762856
113STAT1_20625510_ChIP-Seq_HELA_Human0.80475271
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80268830
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80244140
116EGR1_19032775_ChIP-ChIP_M12_Human0.78863959
117RAC3_21632823_ChIP-Seq_H3396_Human0.78315082
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78250590
119KLF4_19829295_ChIP-Seq_ESCs_Human0.77938954
120GBX2_23144817_ChIP-Seq_PC3_Human0.77070247
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.76999207
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76993798
123VDR_21846776_ChIP-Seq_THP-1_Human0.76406907
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76131159
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76010145
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.75741226
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75149732
128SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.75149727
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75070449
130AR_21572438_ChIP-Seq_LNCaP_Human0.75011124
131SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74746544
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.74524556
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74516958
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74091801
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.73157340
136* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72832086
137HTT_18923047_ChIP-ChIP_STHdh_Human0.71554001
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.71454987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.48598146
2MP0002837_dystrophic_cardiac_calcinosis6.01448621
3MP0000751_myopathy5.64762612
4MP0000749_muscle_degeneration5.09374286
5MP0004145_abnormal_muscle_electrophysio4.62180316
6MP0004084_abnormal_cardiac_muscle4.41334368
7MP0004036_abnormal_muscle_relaxation4.38308203
8MP0004215_abnormal_myocardial_fiber3.75161731
9MP0005330_cardiomyopathy3.42843138
10MP0004087_abnormal_muscle_fiber3.38022293
11MP0002106_abnormal_muscle_physiology3.32554286
12MP0004130_abnormal_muscle_cell3.07195653
13MP0002269_muscular_atrophy3.06215231
14MP0000747_muscle_weakness3.03727374
15MP0005620_abnormal_muscle_contractility2.96664567
16MP0000750_abnormal_muscle_regeneration2.91624760
17MP0000759_abnormal_skeletal_muscle2.77889864
18MP0005369_muscle_phenotype2.72617954
19MP0002972_abnormal_cardiac_muscle2.54042250
20MP0004233_abnormal_muscle_weight2.48036016
21MP0003137_abnormal_impulse_conducting2.41098481
22MP0010630_abnormal_cardiac_muscle2.23587421
23MP0008775_abnormal_heart_ventricle2.18420727
24MP0004484_altered_response_of2.17392497
25MP0006036_abnormal_mitochondrial_physio2.09412456
26MP0005385_cardiovascular_system_phenoty2.08980150
27MP0001544_abnormal_cardiovascular_syste2.08980150
28MP0003221_abnormal_cardiomyocyte_apopto1.94238552
29MP0002332_abnormal_exercise_endurance1.89217163
30MP0006138_congestive_heart_failure1.64452461
31MP0003828_pulmonary_edema1.61481931
32MP0004085_abnormal_heartbeat1.54406653
33MP0004510_myositis1.47671888
34MP0005666_abnormal_adipose_tissue1.43934961
35MP0002108_abnormal_muscle_morphology1.34838243
36MP0002127_abnormal_cardiovascular_syste1.30080997
37MP0003950_abnormal_plasma_membrane1.25559348
38MP0004185_abnormal_adipocyte_glucose1.24894549
39MP0006035_abnormal_mitochondrial_morpho1.15836774
40MP0000733_abnormal_muscle_development1.11162363
41MP0005670_abnormal_white_adipose1.06415900
42MP0005375_adipose_tissue_phenotype1.04554244
43MP0005266_abnormal_metabolism1.03680811
44MP0000013_abnormal_adipose_tissue1.02854467
45MP0000343_altered_response_to1.02603702
46MP0000266_abnormal_heart_morphology0.97418952
47MP0001661_extended_life_span0.96343378
48MP0003567_abnormal_fetal_cardiomyocyte0.91671126
49MP0002971_abnormal_brown_adipose0.85190656
50MP0004043_abnormal_pH_regulation0.83553158
51MP0002234_abnormal_pharynx_morphology0.80961971
52MP0009780_abnormal_chondrocyte_physiolo0.79612003
53MP0003806_abnormal_nucleotide_metabolis0.75493089
54MP0003879_abnormal_hair_cell0.72744713
55MP0005165_increased_susceptibility_to0.70792802
56MP0000003_abnormal_adipose_tissue0.67774441
57MP0002909_abnormal_adrenal_gland0.67494415
58MP0004147_increased_porphyrin_level0.62671250
59MP0000230_abnormal_systemic_arterial0.62108737
60MP0004134_abnormal_chest_morphology0.61510349
61MP0008961_abnormal_basal_metabolism0.61327903
62MP0002078_abnormal_glucose_homeostasis0.60879202
63MP0000372_irregular_coat_pigmentation0.58506341
64MP0001299_abnormal_eye_distance/0.55868304
65MP0002128_abnormal_blood_circulation0.52602224
66MP0005423_abnormal_somatic_nervous0.51249808
67MP0003279_aneurysm0.50276858
68MP0002822_catalepsy0.47410144
69MP0002734_abnormal_mechanical_nocicepti0.46328621
70MP0008569_lethality_at_weaning0.46139777
71MP0001346_abnormal_lacrimal_gland0.45371935
72MP0003705_abnormal_hypodermis_morpholog0.45000203
73MP0009672_abnormal_birth_weight0.43576879
74MP0010030_abnormal_orbit_morphology0.42653416
75MP0005334_abnormal_fat_pad0.42101915
76MP0003656_abnormal_erythrocyte_physiolo0.41703267
77MP0004270_analgesia0.41598697
78MP0005167_abnormal_blood-brain_barrier0.41582634
79MP0010368_abnormal_lymphatic_system0.40628232
80MP0005451_abnormal_body_composition0.39700909
81MP0002638_abnormal_pupillary_reflex0.39133916
82MP0005319_abnormal_enzyme/_coenzyme0.38489672
83MP0005535_abnormal_body_temperature0.38086518
84MP0005166_decreased_susceptibility_to0.37925017
85MP0002114_abnormal_axial_skeleton0.37853844
86MP0003045_fibrosis0.35346157
87MP0005623_abnormal_meninges_morphology0.35273361
88MP0009250_abnormal_appendicular_skeleto0.32908858
89MP0005452_abnormal_adipose_tissue0.31388435
90MP0003948_abnormal_gas_homeostasis0.31335389
91MP0005584_abnormal_enzyme/coenzyme_acti0.30363081
92MP0004924_abnormal_behavior0.30291075
93MP0005386_behavior/neurological_phenoty0.30291075
94MP0009115_abnormal_fat_cell0.28129654
95MP0002896_abnormal_bone_mineralization0.27695587
96MP0002925_abnormal_cardiovascular_devel0.27662818
97MP0003566_abnormal_cell_adhesion0.27589391
98MP0006276_abnormal_autonomic_nervous0.27555790
99MP0001943_abnormal_respiration0.26890307
100MP0001879_abnormal_lymphatic_vessel0.26747617
101MP0003959_abnormal_lean_body0.25383160
102MP0002249_abnormal_larynx_morphology0.24938215
103MP0002067_abnormal_sensory_capabilities0.24329377
104MP0005083_abnormal_biliary_tract0.24078978
105MP0004142_abnormal_muscle_tone0.23632258
106MP0005187_abnormal_penis_morphology0.23030939
107MP0004858_abnormal_nervous_system0.22934695
108MP0005376_homeostasis/metabolism_phenot0.22901392
109MP0000767_abnormal_smooth_muscle0.22469380
110MP0008874_decreased_physiological_sensi0.22095791
111MP0002118_abnormal_lipid_homeostasis0.21916040
112MP0005332_abnormal_amino_acid0.21604901
113MP0001784_abnormal_fluid_regulation0.21257307
114MP0005058_abnormal_lysosome_morphology0.20275448
115MP0002970_abnormal_white_adipose0.19743380
116MP0006072_abnormal_retinal_apoptosis0.18420956
117MP0004859_abnormal_synaptic_plasticity0.16997166
118MP0002066_abnormal_motor_capabilities/c0.16959188
119MP0001440_abnormal_grooming_behavior0.16818437
120MP0001614_abnormal_blood_vessel0.16435022
121MP0003984_embryonic_growth_retardation0.16302929
122MP0003633_abnormal_nervous_system0.16049216
123MP0002088_abnormal_embryonic_growth/wei0.14656984
124MP0000762_abnormal_tongue_morphology0.13792916

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.04982536
2Exercise-induced muscle cramps (HP:0003710)7.60181345
3Muscle hypertrophy of the lower extremities (HP:0008968)7.21912000
4Calf muscle hypertrophy (HP:0008981)7.12415751
5Muscle fiber inclusion bodies (HP:0100299)6.26640821
6Sudden death (HP:0001699)6.11561881
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.99376304
8Muscle fiber splitting (HP:0003555)5.70034854
9Myoglobinuria (HP:0002913)5.64253404
10Nemaline bodies (HP:0003798)5.35978912
11Hyporeflexia of lower limbs (HP:0002600)5.24594812
12Abnormality of the calf musculature (HP:0001430)5.18316684
13Ventricular tachycardia (HP:0004756)5.01997345
14Type 1 muscle fiber predominance (HP:0003803)4.77947806
15EMG: myopathic abnormalities (HP:0003458)4.73998111
16Difficulty running (HP:0009046)4.71635231
17Abnormality of the left ventricular outflow tract (HP:0011103)4.62527947
18Subaortic stenosis (HP:0001682)4.62527947
19Rhabdomyolysis (HP:0003201)4.46558748
20Increased connective tissue (HP:0009025)4.19265086
21Myotonia (HP:0002486)4.18211075
22Asymmetric septal hypertrophy (HP:0001670)4.15684073
23Atrial fibrillation (HP:0005110)4.09895102
24Muscle stiffness (HP:0003552)4.06142753
25Distal arthrogryposis (HP:0005684)3.88499873
26Lipoatrophy (HP:0100578)3.85726167
27Primary atrial arrhythmia (HP:0001692)3.83281057
28Myopathic facies (HP:0002058)3.80362613
29Supraventricular tachycardia (HP:0004755)3.69715023
30Supraventricular arrhythmia (HP:0005115)3.60380121
31Bundle branch block (HP:0011710)3.56869580
32Round ear (HP:0100830)3.46557940
33Difficulty climbing stairs (HP:0003551)3.40578172
34Palpitations (HP:0001962)3.39815913
35Dilated cardiomyopathy (HP:0001644)3.33852836
36Areflexia of lower limbs (HP:0002522)3.19564244
37Right ventricular cardiomyopathy (HP:0011663)3.18631657
38Neck muscle weakness (HP:0000467)3.17160887
39Syncope (HP:0001279)3.09456306
40Prolonged QT interval (HP:0001657)3.07318700
41Ulnar deviation of the wrist (HP:0003049)3.07165486
42Abnormality of skeletal muscle fiber size (HP:0012084)3.05985143
43Ventricular arrhythmia (HP:0004308)2.99947198
44Increased variability in muscle fiber diameter (HP:0003557)2.97263907
45Rimmed vacuoles (HP:0003805)2.94852658
46Heart block (HP:0012722)2.94670980
47Distal lower limb muscle weakness (HP:0009053)2.83501821
48Abnormal atrioventricular conduction (HP:0005150)2.75448773
49Fetal akinesia sequence (HP:0001989)2.70502621
50Atrioventricular block (HP:0001678)2.60220173
51Abnormal mitochondria in muscle tissue (HP:0008316)2.55727204
52Slender build (HP:0001533)2.55571627
53Ventricular fibrillation (HP:0001663)2.55539232
54Calcaneovalgus deformity (HP:0001848)2.51980097
55Acute necrotizing encephalopathy (HP:0006965)2.50623505
56Abnormality of the calcaneus (HP:0008364)2.49951339
57Weak cry (HP:0001612)2.48707877
58EMG: neuropathic changes (HP:0003445)2.48549118
59Scapular winging (HP:0003691)2.48159105
60Left ventricular hypertrophy (HP:0001712)2.43015439
61Ketoacidosis (HP:0001993)2.39002323
62Abnormal EKG (HP:0003115)2.35596414
63Spinal rigidity (HP:0003306)2.33918600
64Limb-girdle muscle atrophy (HP:0003797)2.32652446
65Absent phalangeal crease (HP:0006109)2.31592390
66Hepatic necrosis (HP:0002605)2.31105752
67Frequent falls (HP:0002359)2.30999364
68Muscular dystrophy (HP:0003560)2.29803257
69Hypoplastic ischia (HP:0003175)2.27471508
70Hip contracture (HP:0003273)2.25918444
71Deformed tarsal bones (HP:0008119)2.24169077
72Abnormality of alanine metabolism (HP:0010916)2.22773113
73Hyperalaninemia (HP:0003348)2.22773113
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22773113
75Progressive muscle weakness (HP:0003323)2.21573547
76Acute encephalopathy (HP:0006846)2.18082144
77Gowers sign (HP:0003391)2.15339798
78Generalized muscle weakness (HP:0003324)2.15233741
79Exercise intolerance (HP:0003546)2.11905647
80Proximal amyotrophy (HP:0007126)2.10269424
81Hepatocellular necrosis (HP:0001404)2.07903248
82Distal lower limb amyotrophy (HP:0008944)2.07451304
83Mildly elevated creatine phosphokinase (HP:0008180)2.07078236
84Progressive macrocephaly (HP:0004481)2.06974131
85Facial diplegia (HP:0001349)2.06563528
86Waddling gait (HP:0002515)2.04508697
87Malignant hyperthermia (HP:0002047)2.01629034
88Abnormality of the shoulder girdle musculature (HP:0001435)2.00680130
89Lower limb amyotrophy (HP:0007210)2.00185823
90Increased muscle lipid content (HP:0009058)1.99340094
91Pheochromocytoma (HP:0002666)1.98963413
92Hyperkalemia (HP:0002153)1.98672308
93Mitochondrial inheritance (HP:0001427)1.97828044
94Testicular atrophy (HP:0000029)1.96999689
95Abnormality of the ischium (HP:0003174)1.96839339
96Abnormality of the neuromuscular junction (HP:0003398)1.94704296
97Fatigable weakness (HP:0003473)1.94704296
98Bulbar palsy (HP:0001283)1.94667427
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.91989881
100Large for gestational age (HP:0001520)1.91755048
101Neuroendocrine neoplasm (HP:0100634)1.91364437
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91220444
103Limb-girdle muscle weakness (HP:0003325)1.89940307
104Palmoplantar keratoderma (HP:0000982)1.89617190
105Increased CSF lactate (HP:0002490)1.88868015
106Abnormal finger flexion creases (HP:0006143)1.87861715
107Conjunctival hamartoma (HP:0100780)1.84013675
108Abnormality of the foot musculature (HP:0001436)1.83908199
109Foot dorsiflexor weakness (HP:0009027)1.83480576
110Cerebral edema (HP:0002181)1.83006210
111Abnormality of the hip-girdle musculature (HP:0001445)1.82897538
112Abnormality of the musculature of the pelvis (HP:0001469)1.82897538
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.82819723
114Metatarsus adductus (HP:0001840)1.81078083
115Long clavicles (HP:0000890)1.80578971
116Shoulder girdle muscle weakness (HP:0003547)1.79417780
117Pelvic girdle muscle weakness (HP:0003749)1.77967523
118Ragged-red muscle fibers (HP:0003200)1.75439674
119Popliteal pterygium (HP:0009756)1.74230952
120Nonprogressive disorder (HP:0003680)1.67744731
121Paralysis (HP:0003470)1.67527012
122Ulnar deviation of finger (HP:0009465)1.63160502
123Limited hip movement (HP:0008800)1.51165143
124Type 2 muscle fiber atrophy (HP:0003554)1.50937870
125Increased intramyocellular lipid droplets (HP:0012240)1.48569691
126Muscle fiber atrophy (HP:0100295)1.40903892
127Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.35878408
128Steppage gait (HP:0003376)1.35255857
129Oligomenorrhea (HP:0000876)1.28955352
130Adducted thumb (HP:0001181)1.27835256
131Congenital hip dislocation (HP:0001374)1.27545996
132Amniotic constriction ring (HP:0009775)1.24530326
133Abnormality of placental membranes (HP:0011409)1.24530326
134Easy fatigability (HP:0003388)1.22500877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.73196493
2TTN6.33390227
3PHKG25.18391999
4PHKG15.18391999
5PDK43.06022078
6PDK33.06022078
7PINK12.96741225
8NEK12.71821420
9DMPK2.49691710
10LMTK22.28947391
11BCKDK2.25563131
12TRIB32.11912403
13NME12.00476541
14MYLK1.92554710
15MAP2K31.87601949
16MUSK1.86850641
17PIK3CG1.85178307
18PDK21.84207820
19PKN21.82976513
20PIK3CA1.79634781
21MAP3K71.52125269
22STK241.33407637
23EEF2K1.25844743
24MAPK121.24082917
25MARK11.19617642
26PRKAA11.08487262
27ICK1.04513003
28TIE11.03714825
29MAP2K40.98097777
30CCNB10.98006088
31MOS0.94740714
32MAP3K60.92177351
33TRPM70.91491307
34LIMK10.90834581
35MAPKAPK30.90688651
36PRKAA20.89870354
37CAMK2D0.87521169
38MAP3K110.85404455
39GRK70.83516189
40PRKD10.83266241
41RIPK10.79945954
42MAP3K130.74912511
43PAK30.70412964
44MAP2K60.70093730
45ZAK0.67701250
46MAP3K50.64021689
47ILK0.63470668
48CDC42BPA0.60745736
49PKN10.60572873
50STK380.58841397
51MAP3K30.58096800
52STK38L0.58054817
53MAPK70.57948785
54NEK90.55322924
55MAPK150.52678708
56ROCK10.51619219
57FLT30.51178077
58CAMK2G0.50413898
59MAPK110.50131798
60PDGFRA0.50097431
61RPS6KL10.47781847
62RPS6KC10.47781847
63MAP2K10.45871158
64CAMK2B0.45557422
65TAOK10.44550755
66CAMK2A0.41385129
67CAMK40.40955463
68PRKACB0.40737483
69AKT20.40142124
70TAOK20.37677396
71RPS6KA60.37423194
72INSRR0.35622923
73LATS20.35424586
74SGK20.33604660
75MAPK130.33300010
76PDPK10.32694524
77ARAF0.32683130
78PRKACA0.32274443
79CAMK10.31786599
80RPS6KB10.30490072
81SGK10.29528685
82WNK10.29161849
83PDK10.29098831
84DAPK20.29096744
85STK40.28673971
86PRPF4B0.28400350
87MAP3K10.28217164
88PAK60.27392058
89DDR20.27292312
90RPS6KA10.27059883
91MARK20.26803645
92PRKACG0.26585735
93EPHB10.25780179
94MAPK100.25558772
95RPS6KA30.25100724
96CDK190.25055660
97ROCK20.23779069
98SIK10.23703422
99MAP3K100.22300980
100KSR20.22184864
101MAP3K40.22136043
102TBK10.21872277
103WNK40.21088842
104RPS6KB20.20922187
105MAP3K90.20867722
106TGFBR20.20746269
107DAPK30.20235294
108PRKD30.18691240
109SGK4940.18614975
110SGK2230.18614975
111PRKG10.17698690
112UHMK10.17542486
113PRKD20.15931452
114PTK60.15509865
115MARK30.13365756
116DYRK1B0.12798836
117RAF10.12755300
118PRKCH0.12661531
119NME20.12379727
120MAPK40.12345487
121MTOR0.12313562
122BRAF0.11850361
123RPS6KA20.11821975
124SGK30.11591494
125ERBB30.11377388
126PTK2B0.08603433
127LATS10.07616750
128STK110.07136761
129KSR10.05757588
130TNK20.05646214
131MAPK90.04276674
132GSK3B0.04011522
133MAPK80.03709468
134CDK50.02152345

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.70330330
2Cardiac muscle contraction_Homo sapiens_hsa042604.27988520
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.25594177
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.76193048
5Dilated cardiomyopathy_Homo sapiens_hsa054143.60821314
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04193648
7Parkinsons disease_Homo sapiens_hsa050123.00595678
8Propanoate metabolism_Homo sapiens_hsa006402.89048264
9Oxidative phosphorylation_Homo sapiens_hsa001902.86481250
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.67757588
11Carbon metabolism_Homo sapiens_hsa012002.40945915
12Alzheimers disease_Homo sapiens_hsa050102.28991794
13Fatty acid degradation_Homo sapiens_hsa000712.20222420
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04971298
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02747466
16Fatty acid metabolism_Homo sapiens_hsa012121.86623207
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86167058
18Huntingtons disease_Homo sapiens_hsa050161.77005495
19Pyruvate metabolism_Homo sapiens_hsa006201.72327934
20Viral myocarditis_Homo sapiens_hsa054161.53915878
21Starch and sucrose metabolism_Homo sapiens_hsa005001.49678149
22Glucagon signaling pathway_Homo sapiens_hsa049221.49190532
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47299497
24Insulin signaling pathway_Homo sapiens_hsa049101.40568137
25Biosynthesis of amino acids_Homo sapiens_hsa012301.38624047
26Circadian rhythm_Homo sapiens_hsa047101.33005460
27Insulin resistance_Homo sapiens_hsa049311.29862002
28Oxytocin signaling pathway_Homo sapiens_hsa049211.23157361
29Calcium signaling pathway_Homo sapiens_hsa040201.17159784
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13216699
31Butanoate metabolism_Homo sapiens_hsa006501.12257872
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.11533812
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11105432
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07070429
35AMPK signaling pathway_Homo sapiens_hsa041521.05927828
36Fructose and mannose metabolism_Homo sapiens_hsa000511.04590309
37Nitrogen metabolism_Homo sapiens_hsa009101.02196826
38Galactose metabolism_Homo sapiens_hsa000520.97794417
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96015077
40Fatty acid biosynthesis_Homo sapiens_hsa000610.95782822
41Arginine and proline metabolism_Homo sapiens_hsa003300.91580951
42Fatty acid elongation_Homo sapiens_hsa000620.80590148
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77241359
44HIF-1 signaling pathway_Homo sapiens_hsa040660.72852641
45Type II diabetes mellitus_Homo sapiens_hsa049300.72146082
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70779392
47Arginine biosynthesis_Homo sapiens_hsa002200.70159834
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.70149706
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.65772860
50Gastric acid secretion_Homo sapiens_hsa049710.65743889
51Insulin secretion_Homo sapiens_hsa049110.64858153
52PPAR signaling pathway_Homo sapiens_hsa033200.62870948
53Tight junction_Homo sapiens_hsa045300.62839900
54mTOR signaling pathway_Homo sapiens_hsa041500.60980246
55Focal adhesion_Homo sapiens_hsa045100.59812521
56Renin secretion_Homo sapiens_hsa049240.59426624
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57887973
58Lysine degradation_Homo sapiens_hsa003100.50082162
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49742505
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49431702
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48478868
62GnRH signaling pathway_Homo sapiens_hsa049120.48395141
63Long-term depression_Homo sapiens_hsa047300.47493166
64Amphetamine addiction_Homo sapiens_hsa050310.46671527
65beta-Alanine metabolism_Homo sapiens_hsa004100.45546578
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44369918
67Circadian entrainment_Homo sapiens_hsa047130.43205700
68VEGF signaling pathway_Homo sapiens_hsa043700.39422576
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36090356
70Glioma_Homo sapiens_hsa052140.36009055
71cAMP signaling pathway_Homo sapiens_hsa040240.33518225
72Olfactory transduction_Homo sapiens_hsa047400.30749371
73Cholinergic synapse_Homo sapiens_hsa047250.30478924
74MAPK signaling pathway_Homo sapiens_hsa040100.29684478
75FoxO signaling pathway_Homo sapiens_hsa040680.28794939
76Pentose phosphate pathway_Homo sapiens_hsa000300.28526211
77Tryptophan metabolism_Homo sapiens_hsa003800.28150157
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27431631
79Melanogenesis_Homo sapiens_hsa049160.26487848
80Adherens junction_Homo sapiens_hsa045200.26326329
81Peroxisome_Homo sapiens_hsa041460.25741950
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25605821
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25585011
84Histidine metabolism_Homo sapiens_hsa003400.24934549
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24320665
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23042351
87Gap junction_Homo sapiens_hsa045400.22420330
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.20722927
89Regulation of autophagy_Homo sapiens_hsa041400.20716940
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20488387
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20361431
92Metabolic pathways_Homo sapiens_hsa011000.19120729
93Dorso-ventral axis formation_Homo sapiens_hsa043200.19083473
94Platelet activation_Homo sapiens_hsa046110.18788535
95Long-term potentiation_Homo sapiens_hsa047200.18089534
96GABAergic synapse_Homo sapiens_hsa047270.17896517
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17223781
98Oocyte meiosis_Homo sapiens_hsa041140.16979946
99Pancreatic secretion_Homo sapiens_hsa049720.15480092
100Purine metabolism_Homo sapiens_hsa002300.15200205
101Renal cell carcinoma_Homo sapiens_hsa052110.15039067
102Phenylalanine metabolism_Homo sapiens_hsa003600.14611980
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14551470
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14399534
105Taste transduction_Homo sapiens_hsa047420.14306035
106Tyrosine metabolism_Homo sapiens_hsa003500.14015296
107Thyroid cancer_Homo sapiens_hsa052160.13961947
108Bile secretion_Homo sapiens_hsa049760.11194671
109Morphine addiction_Homo sapiens_hsa050320.11063192
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09855016
111Amoebiasis_Homo sapiens_hsa051460.09509810
112Salivary secretion_Homo sapiens_hsa049700.07815206
113Proteoglycans in cancer_Homo sapiens_hsa052050.07496895
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.07150254
115Dopaminergic synapse_Homo sapiens_hsa047280.05484639
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.04201146
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03368563
118Notch signaling pathway_Homo sapiens_hsa043300.01035780

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