MYB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.74764467
2poly(A)+ mRNA export from nucleus (GO:0016973)5.13415052
3V(D)J recombination (GO:0033151)4.99805191
4DNA unwinding involved in DNA replication (GO:0006268)4.79075432
5positive regulation of gamma-delta T cell activation (GO:0046645)4.73192589
6positive regulation of B cell differentiation (GO:0045579)4.60079981
7DNA strand elongation involved in DNA replication (GO:0006271)4.31590205
8viral transcription (GO:0019083)4.30038071
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24256079
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24256079
11telomere maintenance via semi-conservative replication (GO:0032201)4.22643460
12DNA strand elongation (GO:0022616)4.18024358
13definitive hemopoiesis (GO:0060216)4.17394305
14translational termination (GO:0006415)4.11082605
15regulation of gamma-delta T cell differentiation (GO:0045586)4.04513871
16negative regulation of phagocytosis (GO:0050765)4.03862400
17regulation of granulocyte differentiation (GO:0030852)3.85854765
18DNA replication initiation (GO:0006270)3.73617349
19DNA deamination (GO:0045006)3.69949605
20translational elongation (GO:0006414)3.69669195
21telomere maintenance via recombination (GO:0000722)3.67286353
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.64948499
23T cell homeostasis (GO:0043029)3.63305425
24regulation of gamma-delta T cell activation (GO:0046643)3.59547074
25cotranslational protein targeting to membrane (GO:0006613)3.55717526
26mitotic recombination (GO:0006312)3.55034163
27protein targeting to ER (GO:0045047)3.53691660
28ribosomal small subunit biogenesis (GO:0042274)3.52111776
29granulocyte differentiation (GO:0030851)3.50561663
30protein localization to kinetochore (GO:0034501)3.50447758
31formation of translation preinitiation complex (GO:0001731)3.47887220
32nuclear pore complex assembly (GO:0051292)3.45291893
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44267940
34antigen processing and presentation of endogenous antigen (GO:0019883)3.43940141
35DNA topological change (GO:0006265)3.39827559
36somatic cell DNA recombination (GO:0016444)3.39094350
37somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.39094350
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36965673
39megakaryocyte development (GO:0035855)3.35950261
40protein localization to endoplasmic reticulum (GO:0070972)3.32350060
41maturation of SSU-rRNA (GO:0030490)3.30423807
42Peyers patch development (GO:0048541)3.30236181
43mucosal-associated lymphoid tissue development (GO:0048537)3.30236181
44mitotic sister chromatid cohesion (GO:0007064)3.27102721
45negative regulation of RNA splicing (GO:0033119)3.26614037
46regulation of B cell differentiation (GO:0045577)3.24231764
47mast cell activation (GO:0045576)3.23252229
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23153101
49nuclear pore organization (GO:0006999)3.22201482
50antigen processing and presentation via MHC class Ib (GO:0002475)3.20738932
51interkinetic nuclear migration (GO:0022027)3.20459364
52somatic diversification of immune receptors (GO:0002200)3.20318962
53positive regulation of granulocyte differentiation (GO:0030854)3.17257152
54telomere maintenance via telomere lengthening (GO:0010833)3.16609336
55translesion synthesis (GO:0019985)3.15981100
56negative regulation of granulocyte differentiation (GO:0030853)3.15862892
57cellular protein complex disassembly (GO:0043624)3.15579501
58protein localization to chromosome, centromeric region (GO:0071459)3.15127930
59viral life cycle (GO:0019058)3.12877708
60translational initiation (GO:0006413)3.12849257
61B cell receptor signaling pathway (GO:0050853)3.09542792
62DNA duplex unwinding (GO:0032508)3.07636956
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.06264392
64protein complex disassembly (GO:0043241)3.05866709
65mast cell degranulation (GO:0043303)3.05262570
66mast cell activation involved in immune response (GO:0002279)3.05262570
67negative regulation of thymocyte apoptotic process (GO:0070244)3.03104808
68DNA geometric change (GO:0032392)3.02851545
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01593133
70Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99799272
71protoporphyrinogen IX metabolic process (GO:0046501)2.99262311
72negative regulation of erythrocyte differentiation (GO:0045647)2.95804671
73protein-DNA complex disassembly (GO:0032986)2.94573680
74nucleosome disassembly (GO:0006337)2.94573680
75mature B cell differentiation involved in immune response (GO:0002313)2.93284311
76cellular hyperosmotic response (GO:0071474)2.92894288
77positive regulation of megakaryocyte differentiation (GO:0045654)2.92095476
78DNA ligation (GO:0006266)2.91528435
79IMP metabolic process (GO:0046040)2.91500935
80ribosomal large subunit biogenesis (GO:0042273)2.90247675
81regulation of RNA export from nucleus (GO:0046831)2.88761653
82T cell differentiation in thymus (GO:0033077)2.88744415
83alternative mRNA splicing, via spliceosome (GO:0000380)2.88171412
84IMP biosynthetic process (GO:0006188)2.87538218
85nuclear-transcribed mRNA catabolic process (GO:0000956)2.87411254
86meiotic chromosome segregation (GO:0045132)2.87354215
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86215909
88embryonic hemopoiesis (GO:0035162)2.85796110
89telomere maintenance (GO:0000723)2.85517140
90regulation of histone H3-K27 methylation (GO:0061085)2.84566352
91histone H3-K9 methylation (GO:0051567)2.84115032
92telomere organization (GO:0032200)2.83717272
93macromolecular complex disassembly (GO:0032984)2.82951186
94establishment of integrated proviral latency (GO:0075713)2.82107492
95regulation of erythrocyte differentiation (GO:0045646)2.81820939
96positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.81114421
97hematopoietic stem cell differentiation (GO:0060218)2.80204204
98DNA replication checkpoint (GO:0000076)2.79477569
99lymphoid progenitor cell differentiation (GO:0002320)2.79312744
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79181231
101pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79117577
102centriole replication (GO:0007099)2.77036027
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76987094
104mRNA catabolic process (GO:0006402)2.75077203
105regulation of DNA endoreduplication (GO:0032875)2.74518529
106CENP-A containing nucleosome assembly (GO:0034080)2.73209623
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70670823
108L-fucose catabolic process (GO:0042355)2.69759998
109fucose catabolic process (GO:0019317)2.69759998
110L-fucose metabolic process (GO:0042354)2.69759998
111* regulation of histone H3-K4 methylation (GO:0051569)2.69430201
112RNA catabolic process (GO:0006401)2.69367648
113lymphocyte homeostasis (GO:0002260)2.69095853
114centriole assembly (GO:0098534)2.65688499
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65575973
116pore complex assembly (GO:0046931)2.64631116
1173-UTR-mediated mRNA stabilization (GO:0070935)2.64359858
118DNA replication-independent nucleosome organization (GO:0034724)2.63714897
119DNA replication-independent nucleosome assembly (GO:0006336)2.63714897
120pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.63333472
121chromatin remodeling at centromere (GO:0031055)2.60264886
122negative regulation of histone methylation (GO:0031061)2.59971793
123protoporphyrinogen IX biosynthetic process (GO:0006782)2.59315341
124dosage compensation (GO:0007549)2.59169583
125mitotic chromosome condensation (GO:0007076)2.58378677
126regulation of chromatin silencing (GO:0031935)2.57901345
127DNA conformation change (GO:0071103)2.57521555
128mRNA export from nucleus (GO:0006406)2.57133323
129RNA export from nucleus (GO:0006405)2.56790594
130* regulation of histone H3-K9 methylation (GO:0051570)2.56449137
131histone H3-K9 modification (GO:0061647)2.56288541
132DNA synthesis involved in DNA repair (GO:0000731)2.54893856
133mRNA splice site selection (GO:0006376)2.53323321
134sister chromatid segregation (GO:0000819)2.53181995
135positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52847071
136regulation of B cell receptor signaling pathway (GO:0050855)2.51667040
137positive regulation by host of viral transcription (GO:0043923)2.50965778
138negative thymic T cell selection (GO:0045060)2.49103604
139regulation of translational fidelity (GO:0006450)2.47985409
140folic acid-containing compound biosynthetic process (GO:0009396)2.46443325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.04089450
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.38269565
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33633611
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.25700398
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12517655
6MYC_22102868_ChIP-Seq_BL_Human3.11425642
7* SCL_19346495_ChIP-Seq_HPC-7_Human2.99783702
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70207082
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.68921049
10* VDR_21846776_ChIP-Seq_THP-1_Human2.68446692
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65445333
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55397254
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43148541
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.33266799
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28809828
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26549190
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20595529
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17760850
19CIITA_25753668_ChIP-Seq_RAJI_Human2.14080668
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.14014639
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12291927
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04212496
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94927572
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.91522735
25SPI1_23547873_ChIP-Seq_NB4_Human1.90639939
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90400123
27* MYB_26560356_Chip-Seq_TH2_Human1.88636044
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87798080
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86735259
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86295706
31VDR_23849224_ChIP-Seq_CD4+_Human1.85856946
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.84233002
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83170412
34GATA1_22025678_ChIP-Seq_K562_Human1.82218648
35FOXP3_21729870_ChIP-Seq_TREG_Human1.81988191
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78816859
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77808336
38* VDR_24763502_ChIP-Seq_THP-1_Human1.76701674
39UTX_26944678_Chip-Seq_JUKART_Human1.71296917
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71138317
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70325575
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.68455592
43* MYB_26560356_Chip-Seq_TH1_Human1.65362609
44XRN2_22483619_ChIP-Seq_HELA_Human1.65254813
45MAF_26560356_Chip-Seq_TH1_Human1.65104567
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.64797466
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.59228574
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.58616880
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55509338
50GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50848785
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48356717
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48040353
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47771792
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46326477
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45120131
56GATA1_19941826_ChIP-Seq_K562_Human1.44750199
57* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43978321
58NCOR1_26117541_ChIP-Seq_K562_Human1.43003652
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41381569
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39872997
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39492681
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37462308
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.35786242
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33998118
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33515770
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32347444
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29884668
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29874256
69ELK1_19687146_ChIP-ChIP_HELA_Human1.29732843
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29458243
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29338183
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28802717
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.26570658
74AR_21909140_ChIP-Seq_LNCAP_Human1.26434133
75RUNX_20019798_ChIP-Seq_JUKART_Human1.26312705
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26112108
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26075179
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25559414
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25219771
80GABP_19822575_ChIP-Seq_HepG2_Human1.25119169
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.23690204
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20495837
83* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18257986
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16427895
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15834918
86TTF2_22483619_ChIP-Seq_HELA_Human1.15834013
87KDM5A_27292631_Chip-Seq_BREAST_Human1.14466604
88ETS1_22383799_ChIP-Seq_G1ME_Mouse1.14089089
89* GATA3_27048872_Chip-Seq_THYMUS_Human1.13615357
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12136937
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11584720
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11545375
93DCP1A_22483619_ChIP-Seq_HELA_Human1.11354831
94MAF_26560356_Chip-Seq_TH2_Human1.09924164
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09457260
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08684589
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08183215
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06117426
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04168427
100* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03821971
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03543902
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.02913312
103* GATA2_19941826_ChIP-Seq_K562_Human1.02621900
104* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02410090
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02084502
106* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02008317
107IRF8_27001747_Chip-Seq_BMDM_Mouse1.01976510
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01904476
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.01829194
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00201111
111* SPI1_23127762_ChIP-Seq_K562_Human0.99225395
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99142782
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98928494
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96899635
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96812638
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96776164
117ZNF263_19887448_ChIP-Seq_K562_Human0.95508241
118* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94767766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.54854719
2MP0010094_abnormal_chromosome_stability3.44505023
3MP0005397_hematopoietic_system_phenotyp3.03352257
4MP0001545_abnormal_hematopoietic_system3.03352257
5MP0008057_abnormal_DNA_replication2.97882572
6MP0003693_abnormal_embryo_hatching2.82012200
7* MP0004808_abnormal_hematopoietic_stem2.79437018
8MP0003763_abnormal_thymus_physiology2.77090326
9MP0002166_altered_tumor_susceptibility2.76389752
10MP0001835_abnormal_antigen_presentation2.63641363
11MP0005174_abnormal_tail_pigmentation2.58561960
12* MP0002398_abnormal_bone_marrow2.53248838
13MP0003111_abnormal_nucleus_morphology2.43109658
14MP0000685_abnormal_immune_system2.35576500
15MP0009278_abnormal_bone_marrow2.31423826
16MP0005671_abnormal_response_to2.29108839
17MP0003077_abnormal_cell_cycle2.24692295
18* MP0000703_abnormal_thymus_morphology2.23725902
19MP0000490_abnormal_crypts_of2.23569740
20MP0001800_abnormal_humoral_immune2.18813036
21MP0006054_spinal_hemorrhage2.15455113
22* MP0002722_abnormal_immune_system2.10829409
23MP0005464_abnormal_platelet_physiology2.09532263
24MP0009785_altered_susceptibility_to2.08009501
25MP0002006_tumorigenesis2.06686239
26* MP0000689_abnormal_spleen_morphology2.03708741
27* MP0000716_abnormal_immune_system2.02531417
28MP0002420_abnormal_adaptive_immunity2.00736087
29MP0001819_abnormal_immune_cell1.97301482
30MP0005075_abnormal_melanosome_morpholog1.96565463
31MP0004957_abnormal_blastocyst_morpholog1.95828617
32MP0002095_abnormal_skin_pigmentation1.93204419
33MP0009697_abnormal_copulation1.92525262
34MP0000465_gastrointestinal_hemorrhage1.92118022
35MP0008058_abnormal_DNA_repair1.90702444
36MP0002452_abnormal_antigen_presenting1.88055502
37* MP0002429_abnormal_blood_cell1.86739032
38MP0005409_darkened_coat_color1.85852039
39MP0005025_abnormal_response_to1.85642367
40MP0010155_abnormal_intestine_physiology1.84553303
41MP0002723_abnormal_immune_serum1.81863272
42MP0008007_abnormal_cellular_replicative1.81729093
43MP0002132_abnormal_respiratory_system1.76887359
44MP0003436_decreased_susceptibility_to1.70422569
45MP0005000_abnormal_immune_tolerance1.69837049
46MP0009333_abnormal_splenocyte_physiolog1.69213189
47MP0002019_abnormal_tumor_incidence1.62320594
48MP0002419_abnormal_innate_immunity1.57098487
49MP0008995_early_reproductive_senescence1.56408273
50MP0001873_stomach_inflammation1.55566709
51MP0002405_respiratory_system_inflammati1.54521625
52MP0001790_abnormal_immune_system1.50392290
53MP0005387_immune_system_phenotype1.50392290
54MP0003303_peritoneal_inflammation1.48708271
55MP0001853_heart_inflammation1.47034447
56MP0000015_abnormal_ear_pigmentation1.44070469
57MP0010307_abnormal_tumor_latency1.38984373
58MP0010352_gastrointestinal_tract_polyps1.37717460
59MP0003866_abnormal_defecation1.37547921
60MP0002148_abnormal_hypersensitivity_rea1.36154943
61MP0004185_abnormal_adipocyte_glucose1.31623090
62MP0003300_gastrointestinal_ulcer1.29315931
63MP0003724_increased_susceptibility_to1.29036509
64MP0001986_abnormal_taste_sensitivity1.27258464
65MP0005220_abnormal_exocrine_pancreas1.23485937
66MP0000313_abnormal_cell_death1.20545381
67MP0001845_abnormal_inflammatory_respons1.18326874
68MP0000350_abnormal_cell_proliferation1.15674063
69MP0004947_skin_inflammation1.14896354
70MP0005451_abnormal_body_composition1.10691986
71MP0000681_abnormal_thyroid_gland1.08674556
72MP0004381_abnormal_hair_follicle1.08018718
73MP0004147_increased_porphyrin_level1.06148053
74MP0003656_abnormal_erythrocyte_physiolo1.05681959
75MP0001188_hyperpigmentation0.98651236
76MP0000858_altered_metastatic_potential0.98167297
77MP0003787_abnormal_imprinting0.95862160
78MP0003786_premature_aging0.95132518
79MP0002160_abnormal_reproductive_system0.95018649
80MP0008877_abnormal_DNA_methylation0.93908447
81MP0004264_abnormal_extraembryonic_tissu0.90470501
82MP0001663_abnormal_digestive_system0.86790650
83MP0001730_embryonic_growth_arrest0.85631600
84MP0002075_abnormal_coat/hair_pigmentati0.84745473
85MP0002877_abnormal_melanocyte_morpholog0.83900684
86MP0001929_abnormal_gametogenesis0.79499287
87MP0009765_abnormal_xenobiotic_induced0.76186751
88MP0008469_abnormal_protein_level0.74737751
89MP0003718_maternal_effect0.74712517
90MP0001764_abnormal_homeostasis0.74259584
91MP0001879_abnormal_lymphatic_vessel0.73456828
92* MP0002080_prenatal_lethality0.71784664
93* MP0000598_abnormal_liver_morphology0.71065840
94MP0006292_abnormal_olfactory_placode0.70808707
95MP0000477_abnormal_intestine_morphology0.70301596
96MP0001881_abnormal_mammary_gland0.68807772
97MP0005645_abnormal_hypothalamus_physiol0.68455527
98MP0008932_abnormal_embryonic_tissue0.68451223
99MP0000372_irregular_coat_pigmentation0.68263233
100MP0005666_abnormal_adipose_tissue0.67497743
101MP0001915_intracranial_hemorrhage0.65105456
102MP0003183_abnormal_peptide_metabolism0.64901431
103MP0002009_preneoplasia0.63737793
104MP0005389_reproductive_system_phenotype0.63037173
105MP0002970_abnormal_white_adipose0.62897070
106MP0002933_joint_inflammation0.62453444
107MP0001533_abnormal_skeleton_physiology0.61644438
108MP0003567_abnormal_fetal_cardiomyocyte0.60913277
109MP0001697_abnormal_embryo_size0.60491444
110MP0003984_embryonic_growth_retardation0.59656550
111MP0003172_abnormal_lysosome_physiology0.59479781
112MP0009379_abnormal_foot_pigmentation0.59267543
113MP0006036_abnormal_mitochondrial_physio0.57072727
114MP0003828_pulmonary_edema0.56183709
115MP0008873_increased_physiological_sensi0.55814246
116MP0005076_abnormal_cell_differentiation0.55756836
117MP0002088_abnormal_embryonic_growth/wei0.55340860
118* MP0002086_abnormal_extraembryonic_tissu0.53161209
119MP0001672_abnormal_embryogenesis/_devel0.53087461
120MP0005380_embryogenesis_phenotype0.53087461
121MP0005621_abnormal_cell_physiology0.51714890
122MP0005384_cellular_phenotype0.51274457

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)6.48099119
2Abnormality of B cell number (HP:0010975)6.48099119
3Panhypogammaglobulinemia (HP:0003139)5.23252473
4Hypoplasia of the thymus (HP:0000778)5.10072033
5Thyroiditis (HP:0100646)4.84343751
6Recurrent viral infections (HP:0004429)4.83666890
7Thrombocytosis (HP:0001894)4.40442660
8Abnormal number of erythroid precursors (HP:0012131)4.36980664
9Abnormality of cells of the erythroid lineage (HP:0012130)4.31723568
10T lymphocytopenia (HP:0005403)4.21271353
11Severe combined immunodeficiency (HP:0004430)4.02394839
12Abnormality of T cell number (HP:0011839)3.89994644
13IgM deficiency (HP:0002850)3.85175321
14Eosinophilia (HP:0001880)3.82832899
15Aplastic anemia (HP:0001915)3.82072498
16Cellulitis (HP:0100658)3.76621968
17Reticulocytopenia (HP:0001896)3.75496492
18Recurrent fungal infections (HP:0002841)3.74131848
19* Acute lymphatic leukemia (HP:0006721)3.71217577
20Granulocytopenia (HP:0001913)3.69335577
21Chronic otitis media (HP:0000389)3.67785532
22Agammaglobulinemia (HP:0004432)3.63593721
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.61618686
24Autoimmune hemolytic anemia (HP:0001890)3.61423795
25Combined immunodeficiency (HP:0005387)3.45309015
26Meningitis (HP:0001287)3.45270677
27Abnormality of T cells (HP:0002843)3.40108063
28Hypoproteinemia (HP:0003075)3.33841655
29Petechiae (HP:0000967)3.31237776
30Abnormality of eosinophils (HP:0001879)3.22243953
31Prolonged bleeding time (HP:0003010)3.20974841
32Abnormality of the fingertips (HP:0001211)3.13460199
33Recurrent bronchitis (HP:0002837)3.08959945
34Verrucae (HP:0200043)3.08811276
35Papilloma (HP:0012740)3.08811276
36IgG deficiency (HP:0004315)3.06186396
37Acute myeloid leukemia (HP:0004808)2.98669792
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.88999095
39Volvulus (HP:0002580)2.83438260
40Abnormal platelet function (HP:0011869)2.74070476
41Impaired platelet aggregation (HP:0003540)2.74070476
42Myelodysplasia (HP:0002863)2.72231728
43Lymphoma (HP:0002665)2.69499828
44Abnormality of T cell physiology (HP:0011840)2.65440015
45Leukocytosis (HP:0001974)2.65227265
46Elevated erythrocyte sedimentation rate (HP:0003565)2.60882089
47Aplasia/Hypoplasia of the thymus (HP:0010515)2.57818460
48Abnormality of reticulocytes (HP:0004312)2.56833343
49Pallor (HP:0000980)2.56647770
50Reticulocytosis (HP:0001923)2.56020960
51Autoimmune thrombocytopenia (HP:0001973)2.51148937
52Poikiloderma (HP:0001029)2.46264505
53Abnormality of the prostate (HP:0008775)2.40596480
54Gastrointestinal inflammation (HP:0004386)2.36037513
55Microvesicular hepatic steatosis (HP:0001414)2.35781186
56Recurrent abscess formation (HP:0002722)2.35070246
57Sepsis (HP:0100806)2.32907462
58Osteomyelitis (HP:0002754)2.29170034
59Chromsome breakage (HP:0040012)2.28185001
60Inflammation of the large intestine (HP:0002037)2.27649125
61Recurrent bacterial skin infections (HP:0005406)2.26734024
62Neutropenia (HP:0001875)2.26570057
63Epistaxis (HP:0000421)2.26489336
64Chronic mucocutaneous candidiasis (HP:0002728)2.24251773
65Recurrent cutaneous fungal infections (HP:0011370)2.24251773
66Dyschromatopsia (HP:0007641)2.23096688
67Abnormality of chromosome stability (HP:0003220)2.22982984
68Reduced antithrombin III activity (HP:0001976)2.22126229
69Nasal polyposis (HP:0100582)2.21644870
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.20744767
71Constricted visual fields (HP:0001133)2.20340969
72Increased IgE level (HP:0003212)2.19014235
7311 pairs of ribs (HP:0000878)2.18179586
74Birth length less than 3rd percentile (HP:0003561)2.17861899
75Amaurosis fugax (HP:0100576)2.16528279
76Abnormal rod and cone electroretinograms (HP:0008323)2.15620195
77Chronic sinusitis (HP:0011109)2.15191393
78Abnormality of the thymus (HP:0000777)2.15065887
79Myositis (HP:0100614)2.14510905
80Macrocytic anemia (HP:0001972)2.14083497
81Lymphopenia (HP:0001888)2.12454793
82Abnormality of cells of the lymphoid lineage (HP:0012140)2.10473492
83Cutis marmorata (HP:0000965)2.04953494
84Abnormality of DNA repair (HP:0003254)2.04881763
85Viral hepatitis (HP:0006562)2.03233617
86Obstructive lung disease (HP:0006536)2.03123479
87Chronic obstructive pulmonary disease (HP:0006510)2.03123479
88Long eyelashes (HP:0000527)2.01007121
89Thoracic kyphosis (HP:0002942)2.00587989
90Bone marrow hypocellularity (HP:0005528)1.99352398
91Poikilocytosis (HP:0004447)1.98991895
92Cutaneous melanoma (HP:0012056)1.98576308
93Papilledema (HP:0001085)1.97622870
94Basal cell carcinoma (HP:0002671)1.96447394
95Recurrent skin infections (HP:0001581)1.96371419
96Prominent nose (HP:0000448)1.94771399
97Colitis (HP:0002583)1.94617226
98Type I transferrin isoform profile (HP:0003642)1.94539993
99Seborrheic dermatitis (HP:0001051)1.93300037
100Abnormality of the nasal mucosa (HP:0000433)1.91262697
101Prostate neoplasm (HP:0100787)1.90259132
102Sandal gap (HP:0001852)1.90063865
103Cellular immunodeficiency (HP:0005374)1.89238253
104Entropion (HP:0000621)1.89179243
105Periodontitis (HP:0000704)1.88329478
106Chest pain (HP:0100749)1.87490101
107Pancytopenia (HP:0001876)1.86959791
108Abnormality of male internal genitalia (HP:0000022)1.86546798
109Skin rash (HP:0000988)1.84671177
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83753273
111Bronchitis (HP:0012387)1.83303337
112Muscle fiber atrophy (HP:0100295)1.83014417
113Clubbing of toes (HP:0100760)1.81028986
114Polycythemia (HP:0001901)1.80458092
115Encephalitis (HP:0002383)1.79049547
116Neurodegeneration (HP:0002180)1.78807183
117Abnormal platelet volume (HP:0011876)1.78108886
118Abnormality of the preputium (HP:0100587)1.78056824
119Truncus arteriosus (HP:0001660)1.75299321
120Type 2 muscle fiber atrophy (HP:0003554)1.74075772
121Hyperacusis (HP:0010780)1.73930551
122Oral leukoplakia (HP:0002745)1.73887930
123Abnormal hemoglobin (HP:0011902)1.73875572
124Abnormality of the columella (HP:0009929)1.73503909
125Abnormality of the thoracic spine (HP:0100711)1.71862550
126Short middle phalanx of the 5th finger (HP:0004220)1.71328013
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.69069784
128Absent/shortened dynein arms (HP:0200106)1.69069784
129Fatigue (HP:0012378)1.67080527
130Premature ovarian failure (HP:0008209)1.66856629
131Attenuation of retinal blood vessels (HP:0007843)1.65473873
132Ankyloglossia (HP:0010296)1.65423071
133Nephroblastoma (Wilms tumor) (HP:0002667)1.61271687
134Central scotoma (HP:0000603)1.60993483
135Microcytic anemia (HP:0001935)1.58692593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.81323934
2MAP3K103.60231533
3MAP4K12.89845791
4CDC72.77148998
5WEE12.45837632
6BTK2.37175118
7RPS6KB22.06228221
8KIT2.04453464
9TEC2.04135728
10STK161.95796017
11SMG11.88070032
12GRK61.87876364
13NEK21.86635174
14PKN21.85404192
15SYK1.78431856
16FLT31.77675047
17TXK1.77177302
18DYRK31.60772314
19TAOK31.59029908
20PRPF4B1.58923082
21ZAP701.58708450
22STK101.56967863
23TAF11.54853417
24VRK21.49909714
25PLK41.49401273
26CDK41.48301852
27NUAK11.46378793
28MKNK11.46241216
29ATR1.41412569
30NME21.38329489
31VRK11.37380218
32PIM21.37360338
33BRSK21.36198452
34MKNK21.35372887
35EIF2AK31.35006854
36CLK11.32066259
37PIM11.30632113
38LRRK21.29648071
39STK41.26731413
40IRAK41.26475079
41SRPK11.26318115
42SCYL21.23679000
43MAP3K141.22524206
44TGFBR11.21571163
45BUB11.19219575
46CSF1R1.18336320
47FES1.17016880
48MAP2K31.15782547
49TNIK1.11257888
50JAK31.10880756
51BLK1.09352046
52ERN11.08127906
53RPS6KA41.07907206
54PASK1.07893490
55MAP3K131.07094897
56BMPR21.05673419
57MATK1.05567777
58MAPKAPK31.04632566
59CDK71.00515562
60ITK0.94681531
61LYN0.91513580
62LCK0.89483601
63CDK120.88888333
64ZAK0.88624624
65ACVR1B0.87490782
66CDK60.87464381
67TYK20.86806189
68MAP4K20.83892355
69MAPKAPK50.83799679
70TLK10.83592812
71BCKDK0.82387291
72PBK0.81442668
73TESK20.79919769
74HIPK20.79736493
75HCK0.78214547
76NLK0.77867448
77CCNB10.77362884
78CDK190.76996931
79TRIB30.76700899
80AURKB0.75964061
81RAF10.74635832
82YES10.72522134
83BRD40.70610891
84EIF2AK20.70557085
85MAP3K80.69482382
86SIK20.68745132
87CDK80.68684138
88MAP2K20.67959882
89TSSK60.67906718
90TRPM70.66812110
91TBK10.64688130
92CDK30.63887420
93RPS6KA50.63848480
94JAK20.63405773
95MAP3K60.62977168
96TNK20.62893868
97MAPK110.61727935
98* MAPK40.61604203
99PRKCQ0.61509686
100CHEK10.60996713
101ALK0.57206568
102TTK0.55166283
103ATM0.54142565
104PLK10.53757238
105BRSK10.53162723
106MAP3K70.52781629
107CDK90.52723971
108RPS6KB10.52639300
109EIF2AK10.52419315
110RPS6KA60.50569557
111CHEK20.50538216
112RIPK40.50537468
113* MAPK30.49037992
114PIK3CG0.47500146
115RPS6KL10.45544080
116RPS6KC10.45544080
117* CDK10.44736646
118MAP3K120.44158774
119IKBKE0.43065210
120DAPK10.42287855
121* CDK20.41702318
122KDR0.39349546
123STK240.39132826

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86053276
2Primary immunodeficiency_Homo sapiens_hsa053403.75692743
3Non-homologous end-joining_Homo sapiens_hsa034503.56645657
4Mismatch repair_Homo sapiens_hsa034303.48335532
5Ribosome_Homo sapiens_hsa030103.36240877
6Base excision repair_Homo sapiens_hsa034102.92236868
7Homologous recombination_Homo sapiens_hsa034402.60580500
8Spliceosome_Homo sapiens_hsa030402.44319178
9Cell cycle_Homo sapiens_hsa041102.19779993
10Nucleotide excision repair_Homo sapiens_hsa034202.03946298
11B cell receptor signaling pathway_Homo sapiens_hsa046621.89626881
12Fanconi anemia pathway_Homo sapiens_hsa034601.80733266
13Pyrimidine metabolism_Homo sapiens_hsa002401.73665319
14Antigen processing and presentation_Homo sapiens_hsa046121.71408751
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63766870
16RNA transport_Homo sapiens_hsa030131.63080869
17Hematopoietic cell lineage_Homo sapiens_hsa046401.53120538
18One carbon pool by folate_Homo sapiens_hsa006701.51783312
19Herpes simplex infection_Homo sapiens_hsa051681.46257376
20Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43971852
21RNA degradation_Homo sapiens_hsa030181.42024473
22Acute myeloid leukemia_Homo sapiens_hsa052211.41982512
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.38818484
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37291817
25RNA polymerase_Homo sapiens_hsa030201.35497866
26Measles_Homo sapiens_hsa051621.34235548
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29723816
28Leishmaniasis_Homo sapiens_hsa051401.28585303
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.24647502
30Chronic myeloid leukemia_Homo sapiens_hsa052201.24147924
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20569223
32Systemic lupus erythematosus_Homo sapiens_hsa053221.17186341
33Pentose phosphate pathway_Homo sapiens_hsa000301.15403701
34N-Glycan biosynthesis_Homo sapiens_hsa005101.13847483
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10711185
36mRNA surveillance pathway_Homo sapiens_hsa030151.10280317
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09784093
38Viral carcinogenesis_Homo sapiens_hsa052031.09071922
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06439206
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05151029
41p53 signaling pathway_Homo sapiens_hsa041151.05055405
42Hepatitis B_Homo sapiens_hsa051611.03739418
43Non-small cell lung cancer_Homo sapiens_hsa052231.03060512
44Thyroid cancer_Homo sapiens_hsa052161.02443875
45T cell receptor signaling pathway_Homo sapiens_hsa046601.02052159
46Osteoclast differentiation_Homo sapiens_hsa043800.99663898
47Epstein-Barr virus infection_Homo sapiens_hsa051690.98442108
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96246537
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95363579
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92443868
51Platelet activation_Homo sapiens_hsa046110.91605093
52Basal transcription factors_Homo sapiens_hsa030220.89100141
53Purine metabolism_Homo sapiens_hsa002300.84557358
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82460279
55mTOR signaling pathway_Homo sapiens_hsa041500.81069995
56Protein export_Homo sapiens_hsa030600.78504336
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.75273916
58Apoptosis_Homo sapiens_hsa042100.75228530
59Small cell lung cancer_Homo sapiens_hsa052220.74024312
60* HTLV-I infection_Homo sapiens_hsa051660.72980323
61Shigellosis_Homo sapiens_hsa051310.71020829
62Proteasome_Homo sapiens_hsa030500.70419176
63Influenza A_Homo sapiens_hsa051640.69976123
64Colorectal cancer_Homo sapiens_hsa052100.69204414
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.68600347
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68398049
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67924065
68Legionellosis_Homo sapiens_hsa051340.66668807
69Allograft rejection_Homo sapiens_hsa053300.65430341
70Sulfur relay system_Homo sapiens_hsa041220.65403650
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.64640396
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63742203
73Toxoplasmosis_Homo sapiens_hsa051450.63731176
74African trypanosomiasis_Homo sapiens_hsa051430.62350623
75Nitrogen metabolism_Homo sapiens_hsa009100.60168318
76Pancreatic cancer_Homo sapiens_hsa052120.60067816
77Prolactin signaling pathway_Homo sapiens_hsa049170.59071181
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58446338
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56794379
80Lysine degradation_Homo sapiens_hsa003100.56570107
81Olfactory transduction_Homo sapiens_hsa047400.54473417
82Asthma_Homo sapiens_hsa053100.53926311
83Renin-angiotensin system_Homo sapiens_hsa046140.53494440
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.53031593
85Inositol phosphate metabolism_Homo sapiens_hsa005620.51846929
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51226026
87Other glycan degradation_Homo sapiens_hsa005110.50627950
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49933881
89Butanoate metabolism_Homo sapiens_hsa006500.49838617
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49619568
91VEGF signaling pathway_Homo sapiens_hsa043700.48064005
92Glioma_Homo sapiens_hsa052140.47469555
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47296652
94Chemokine signaling pathway_Homo sapiens_hsa040620.47257523
95Alcoholism_Homo sapiens_hsa050340.46825520
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.45924025
97MicroRNAs in cancer_Homo sapiens_hsa052060.45625794
98Dorso-ventral axis formation_Homo sapiens_hsa043200.45459927
99Caffeine metabolism_Homo sapiens_hsa002320.44201102
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43347917
101Prostate cancer_Homo sapiens_hsa052150.41751917
102Pertussis_Homo sapiens_hsa051330.40943125
103Choline metabolism in cancer_Homo sapiens_hsa052310.40593205
104Tuberculosis_Homo sapiens_hsa051520.38878836
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36897512
106ErbB signaling pathway_Homo sapiens_hsa040120.36820148
107Carbon metabolism_Homo sapiens_hsa012000.36689461
108Endometrial cancer_Homo sapiens_hsa052130.36418041
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.36177789
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35895868
111FoxO signaling pathway_Homo sapiens_hsa040680.34693424
112Type I diabetes mellitus_Homo sapiens_hsa049400.34403756
113Selenocompound metabolism_Homo sapiens_hsa004500.32409088
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32056654
115Autoimmune thyroid disease_Homo sapiens_hsa053200.31453861
116Bladder cancer_Homo sapiens_hsa052190.29732076
117Hepatitis C_Homo sapiens_hsa051600.28653062
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.28630496
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28449989
120TNF signaling pathway_Homo sapiens_hsa046680.27982120
121Graft-versus-host disease_Homo sapiens_hsa053320.27737819
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26660420
123Viral myocarditis_Homo sapiens_hsa054160.25422151
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25329975
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24909407
126HIF-1 signaling pathway_Homo sapiens_hsa040660.24376097

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