MYBBP1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.20051846
2nuclear pore organization (GO:0006999)5.11843513
3folic acid-containing compound biosynthetic process (GO:0009396)5.08930106
4nuclear pore complex assembly (GO:0051292)4.98982443
5protein localization to kinetochore (GO:0034501)4.77368733
6IMP biosynthetic process (GO:0006188)4.59939547
7mitotic nuclear envelope disassembly (GO:0007077)4.51810938
8nucleobase biosynthetic process (GO:0046112)4.43808534
9proline biosynthetic process (GO:0006561)4.31062700
10formation of translation preinitiation complex (GO:0001731)4.27855575
11nuclear envelope disassembly (GO:0051081)4.21408348
12membrane disassembly (GO:0030397)4.21408348
13regulation of translational fidelity (GO:0006450)4.12814605
14DNA replication initiation (GO:0006270)4.07617988
15COPI coating of Golgi vesicle (GO:0048205)4.05883004
16Golgi transport vesicle coating (GO:0048200)4.05883004
17regulation of mammary gland epithelial cell proliferation (GO:0033599)4.04123770
18maturation of SSU-rRNA (GO:0030490)4.00502510
19IMP metabolic process (GO:0046040)3.99222801
20DNA strand elongation involved in DNA replication (GO:0006271)3.90661304
21protein localization to chromosome, centromeric region (GO:0071459)3.89393039
22pre-miRNA processing (GO:0031054)3.87787989
23protein complex localization (GO:0031503)3.87677049
24ribosome assembly (GO:0042255)3.87046737
25DNA replication-dependent nucleosome assembly (GO:0006335)3.85980266
26DNA replication-dependent nucleosome organization (GO:0034723)3.85980266
27heterochromatin organization (GO:0070828)3.83327985
28DNA duplex unwinding (GO:0032508)3.79985874
29regulation of translational termination (GO:0006449)3.79506955
30DNA geometric change (GO:0032392)3.77370124
31regulation of gene silencing by RNA (GO:0060966)3.76129378
32regulation of posttranscriptional gene silencing (GO:0060147)3.76129378
33regulation of gene silencing by miRNA (GO:0060964)3.76129378
34pore complex assembly (GO:0046931)3.74037151
35cellular protein complex localization (GO:0034629)3.71931521
36DNA strand elongation (GO:0022616)3.71398209
37mitotic metaphase plate congression (GO:0007080)3.69123234
38purine nucleobase biosynthetic process (GO:0009113)3.67874686
39ribosome biogenesis (GO:0042254)3.61493098
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.61202982
41mitotic sister chromatid segregation (GO:0000070)3.59477100
42peptidyl-arginine omega-N-methylation (GO:0035247)3.47414548
43sister chromatid segregation (GO:0000819)3.44772707
44rRNA transcription (GO:0009303)3.44289753
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42038926
46regulation of spindle organization (GO:0090224)3.39940319
47nuclear envelope organization (GO:0006998)3.36786506
48apoptotic process involved in morphogenesis (GO:0060561)3.30994574
49ribonucleoprotein complex biogenesis (GO:0022613)3.29896608
50dosage compensation (GO:0007549)3.29844941
51viral transcription (GO:0019083)3.29218790
52translational initiation (GO:0006413)3.28791597
53translational termination (GO:0006415)3.28494732
54telomere maintenance via semi-conservative replication (GO:0032201)3.28025276
55negative regulation of histone methylation (GO:0031061)3.25319748
56ribosomal large subunit biogenesis (GO:0042273)3.25258682
57positive regulation of chromosome segregation (GO:0051984)3.25232636
58negative regulation of RNA splicing (GO:0033119)3.24010790
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.23636228
60activation of Rac GTPase activity (GO:0032863)3.22396771
61mitotic chromosome condensation (GO:0007076)3.21515467
62adherens junction assembly (GO:0034333)3.21191299
63focal adhesion assembly (GO:0048041)3.19494080
64cell-substrate adherens junction assembly (GO:0007045)3.19494080
65DNA replication checkpoint (GO:0000076)3.18095317
66metaphase plate congression (GO:0051310)3.17260912
67negative regulation of mRNA processing (GO:0050686)3.17103659
68negative regulation of cell size (GO:0045792)3.14798952
69regulation of histone H3-K9 methylation (GO:0051570)3.14286531
70regulation of mitotic spindle organization (GO:0060236)3.14171719
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13387789
72ribosomal small subunit assembly (GO:0000028)3.12624823
73translational elongation (GO:0006414)3.07007964
74protein-DNA complex disassembly (GO:0032986)3.06655566
75nucleosome disassembly (GO:0006337)3.06655566
76chromatin assembly (GO:0031497)3.05249669
77folic acid metabolic process (GO:0046655)3.03165173
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02587486
79histone H2A monoubiquitination (GO:0035518)3.02176332
80protein export from nucleus (GO:0006611)3.01655757
81negative regulation of mRNA metabolic process (GO:1903312)3.01006372
82peptidyl-arginine N-methylation (GO:0035246)3.00958355
83peptidyl-arginine methylation (GO:0018216)3.00958355
84rRNA processing (GO:0006364)2.99264933
85histone arginine methylation (GO:0034969)2.98343609
86mitotic sister chromatid cohesion (GO:0007064)2.96817657
87RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96226447
88mRNA splicing, via spliceosome (GO:0000398)2.96226447
89paraxial mesoderm development (GO:0048339)2.96130108
90RNA splicing, via transesterification reactions (GO:0000375)2.96046015
91regulation of RNA export from nucleus (GO:0046831)2.95924717
92tetrahydrofolate metabolic process (GO:0046653)2.95748171
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94875124
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.94875124
95DNA conformation change (GO:0071103)2.92197348
96pentose-phosphate shunt (GO:0006098)2.92147301
97nucleobase-containing small molecule interconversion (GO:0015949)2.91711122
98mitotic recombination (GO:0006312)2.91366577
99establishment of integrated proviral latency (GO:0075713)2.91364213
100viral mRNA export from host cell nucleus (GO:0046784)2.91030285
101rRNA metabolic process (GO:0016072)2.90252468
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.88739579
103telomere maintenance via recombination (GO:0000722)2.87789908
104mRNA stabilization (GO:0048255)2.87425536
105RNA stabilization (GO:0043489)2.87425536
106mRNA transport (GO:0051028)2.87016439
107spliceosomal snRNP assembly (GO:0000387)2.86555932
108chromosome condensation (GO:0030261)2.86378276
109protein maturation by protein folding (GO:0022417)2.86323696
110protein localization to chromosome (GO:0034502)2.84949969
111DNA topological change (GO:0006265)2.84576845
112telomere maintenance via telomere lengthening (GO:0010833)2.83539504
113regulation of NFAT protein import into nucleus (GO:0051532)2.82869257
114regulation of nucleobase-containing compound transport (GO:0032239)2.82416363
115mitochondrial DNA metabolic process (GO:0032042)2.80733807
116mitotic G1 DNA damage checkpoint (GO:0031571)2.80585277
117chromatin assembly or disassembly (GO:0006333)2.80212543
118ribosomal small subunit biogenesis (GO:0042274)2.79633083
119L-serine metabolic process (GO:0006563)2.78065307
120tRNA methylation (GO:0030488)2.77943759
121nuclear envelope reassembly (GO:0031468)2.77941411
122mitotic nuclear envelope reassembly (GO:0007084)2.77941411
123regulation of sister chromatid cohesion (GO:0007063)2.77066009
124positive regulation of DNA-dependent DNA replication (GO:2000105)2.75904984
125glucocorticoid receptor signaling pathway (GO:0042921)2.75365394
126establishment of chromosome localization (GO:0051303)2.75302165
127pteridine-containing compound biosynthetic process (GO:0042559)2.73022602
128regulation of translational elongation (GO:0006448)2.72945069
129regulation of chromosome segregation (GO:0051983)2.72759450
130maternal placenta development (GO:0001893)2.72258665
131proline metabolic process (GO:0006560)2.71368702
132cell-substrate junction assembly (GO:0007044)2.70170405
133snRNA processing (GO:0016180)2.68893610
134regulation of centrosome cycle (GO:0046605)2.68757310
135transcription from mitochondrial promoter (GO:0006390)2.67503691
1363-UTR-mediated mRNA stabilization (GO:0070935)2.66943533
137negative regulation of chromosome segregation (GO:0051985)2.66477957
138chaperone-mediated protein complex assembly (GO:0051131)2.66165662
139snRNA metabolic process (GO:0016073)2.66134906
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.62989644
141protein retention in ER lumen (GO:0006621)2.58978470
142regulation of histone H3-K27 methylation (GO:0061085)2.57819328
143glucose catabolic process (GO:0006007)2.57323328
144cellular response to epidermal growth factor stimulus (GO:0071364)2.55756979
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55092862
146NADPH regeneration (GO:0006740)2.54850413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55363653
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.35751837
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.12960239
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54437365
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29514101
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09874617
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.92611389
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87295069
9MYC_22102868_ChIP-Seq_BL_Human2.63268877
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62947609
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41515511
12* XRN2_22483619_ChIP-Seq_HELA_Human2.20007835
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16642414
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.10852820
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.05091218
16AR_21909140_ChIP-Seq_LNCAP_Human2.02736631
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02706426
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.93778764
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89346111
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88852199
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78284127
22LXR_22292898_ChIP-Seq_THP-1_Human1.78144073
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78143894
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77099215
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74645749
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74541493
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73799664
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73113103
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71438247
30* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71423223
31CIITA_25753668_ChIP-Seq_RAJI_Human1.69516372
32RACK7_27058665_Chip-Seq_MCF-7_Human1.66287810
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63378672
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.61612492
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61379767
36VDR_23849224_ChIP-Seq_CD4+_Human1.60278105
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57880793
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57650099
39TTF2_22483619_ChIP-Seq_HELA_Human1.57460557
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56119574
41FOXP3_21729870_ChIP-Seq_TREG_Human1.55734820
42KDM5A_27292631_Chip-Seq_BREAST_Human1.53971069
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50596841
44DCP1A_22483619_ChIP-Seq_HELA_Human1.50373661
45VDR_21846776_ChIP-Seq_THP-1_Human1.49605539
46* GABP_19822575_ChIP-Seq_HepG2_Human1.48486156
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48022016
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44131673
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39994268
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39452342
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39151628
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39059475
53* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38527435
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37506962
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36380326
56* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35870148
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34651515
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32990790
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32990790
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32990790
61KDM2B_26808549_Chip-Seq_DND41_Human1.32987223
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32504998
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31477754
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31432094
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30709870
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29163262
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.28246855
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.27918263
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27694584
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27314446
71TFEB_21752829_ChIP-Seq_HELA_Human1.24977440
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22834042
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22188465
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21105872
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19587944
76* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19439078
77P68_20966046_ChIP-Seq_HELA_Human1.18804679
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17181960
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17101361
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16235251
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15751715
82CLOCK_20551151_ChIP-Seq_293T_Human1.15604225
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12879078
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11431323
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11242571
86ELK1_19687146_ChIP-ChIP_HELA_Human1.10529307
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10225129
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09990817
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09916729
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09796203
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.09783334
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09572927
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09453943
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08374398
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07308139
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06774016
97* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06557250
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06114615
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05206000
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.04743926
101NCOR1_26117541_ChIP-Seq_K562_Human1.04423400
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04296881
103* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02894195
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.02335517
105ZNF263_19887448_ChIP-Seq_K562_Human1.02135307
106MAF_26560356_Chip-Seq_TH2_Human1.00512431
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00289886
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99676921
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.99655450
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99456683
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98669854
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98185482
113ATF3_27146783_Chip-Seq_COLON_Human0.97306248
114KDM2B_26808549_Chip-Seq_K562_Human0.96221748
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96137437
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.95033206
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94442215
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94337172
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94119082
120TCF7_22412390_ChIP-Seq_EML_Mouse0.93828890
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92333198
122TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91112907
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91106150
124UTX_26944678_Chip-Seq_JUKART_Human0.90905270
125CHD1_26751641_Chip-Seq_LNCaP_Human0.90580202
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.90474910
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.90142596
128* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89888587
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88257951
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87139288
131MAF_26560356_Chip-Seq_TH1_Human0.86534275
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85789700
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85038000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.22052186
2MP0003111_abnormal_nucleus_morphology3.99747541
3MP0004957_abnormal_blastocyst_morpholog3.88502362
4MP0010094_abnormal_chromosome_stability3.78970750
5MP0003077_abnormal_cell_cycle3.44289752
6MP0008057_abnormal_DNA_replication3.28538928
7MP0010352_gastrointestinal_tract_polyps3.21620988
8MP0005451_abnormal_body_composition2.70645573
9MP0001730_embryonic_growth_arrest2.67282824
10MP0000350_abnormal_cell_proliferation2.42247762
11MP0008007_abnormal_cellular_replicative2.42220602
12MP0003705_abnormal_hypodermis_morpholog2.37895670
13MP0005076_abnormal_cell_differentiation2.28223364
14MP0008058_abnormal_DNA_repair2.21857107
15MP0003123_paternal_imprinting2.17291669
16MP0008932_abnormal_embryonic_tissue2.16757898
17MP0002396_abnormal_hematopoietic_system2.15684194
18MP0010307_abnormal_tumor_latency2.14836709
19MP0005380_embryogenesis_phenotype2.07413235
20MP0001672_abnormal_embryogenesis/_devel2.07413235
21MP0004197_abnormal_fetal_growth/weight/1.95437604
22MP0003984_embryonic_growth_retardation1.93579225
23MP0001697_abnormal_embryo_size1.92935547
24MP0002084_abnormal_developmental_patter1.91055855
25MP0002088_abnormal_embryonic_growth/wei1.90736627
26MP0002085_abnormal_embryonic_tissue1.85420881
27MP0002080_prenatal_lethality1.78012403
28MP0002086_abnormal_extraembryonic_tissu1.77259049
29MP0010030_abnormal_orbit_morphology1.68810794
30MP0008438_abnormal_cutaneous_collagen1.63644273
31MP0004858_abnormal_nervous_system1.63610476
32MP0000537_abnormal_urethra_morphology1.61207017
33MP0002796_impaired_skin_barrier1.58823076
34MP0001661_extended_life_span1.55308809
35MP0000490_abnormal_crypts_of1.53360402
36MP0004808_abnormal_hematopoietic_stem1.52970871
37MP0000678_abnormal_parathyroid_gland1.49779894
38MP0003567_abnormal_fetal_cardiomyocyte1.48673572
39MP0003566_abnormal_cell_adhesion1.48111013
40MP0001348_abnormal_lacrimal_gland1.47517562
41MP0000003_abnormal_adipose_tissue1.46677740
42MP0003786_premature_aging1.40752360
43MP0009053_abnormal_anal_canal1.39646621
44MP0008260_abnormal_autophagy1.38040761
45MP0003890_abnormal_embryonic-extraembry1.33858873
46MP0000313_abnormal_cell_death1.33579340
47MP0002060_abnormal_skin_morphology1.33276150
48MP0001293_anophthalmia1.32524368
49MP0002653_abnormal_ependyma_morphology1.32041948
50MP0001849_ear_inflammation1.30479148
51MP0003119_abnormal_digestive_system1.29672036
52MP0002019_abnormal_tumor_incidence1.28438581
53MP0009278_abnormal_bone_marrow1.27034556
54MP0005023_abnormal_wound_healing1.26133461
55MP0005666_abnormal_adipose_tissue1.23579252
56MP0002249_abnormal_larynx_morphology1.20843004
57MP0000733_abnormal_muscle_development1.20785569
58MP0004272_abnormal_basement_membrane1.20389358
59MP0009672_abnormal_birth_weight1.18284473
60MP0009333_abnormal_splenocyte_physiolog1.17734948
61MP0003806_abnormal_nucleotide_metabolis1.17620270
62MP0005375_adipose_tissue_phenotype1.16057788
63MP0008877_abnormal_DNA_methylation1.14284803
64MP0003121_genomic_imprinting1.13378515
65MP0000703_abnormal_thymus_morphology1.12880597
66MP0000579_abnormal_nail_morphology1.11734233
67MP0001915_intracranial_hemorrhage1.11451029
68MP0000428_abnormal_craniofacial_morphol1.10976975
69MP0005058_abnormal_lysosome_morphology1.09492321
70MP0002089_abnormal_postnatal_growth/wei1.08765500
71MP0000751_myopathy1.07084402
72MP0003091_abnormal_cell_migration1.05795730
73MP0000747_muscle_weakness1.05576452
74MP0002111_abnormal_tail_morphology1.02979384
75MP0003763_abnormal_thymus_physiology1.01325403
76MP0000759_abnormal_skeletal_muscle1.01214602
77MP0001545_abnormal_hematopoietic_system0.99213821
78MP0005397_hematopoietic_system_phenotyp0.99213821
79MP0005257_abnormal_intraocular_pressure0.99031301
80MP0009703_decreased_birth_body0.98270228
81MP0001346_abnormal_lacrimal_gland0.98106482
82MP0002009_preneoplasia0.95803951
83MP0002092_abnormal_eye_morphology0.94989953
84MP0001216_abnormal_epidermal_layer0.93692237
85MP0004087_abnormal_muscle_fiber0.89947791
86MP0002722_abnormal_immune_system0.89391734
87MP0002877_abnormal_melanocyte_morpholog0.89328676
88MP0002398_abnormal_bone_marrow0.89260750
89MP0010630_abnormal_cardiac_muscle0.89235995
90MP0002697_abnormal_eye_size0.89128957
91MP0001873_stomach_inflammation0.89017376
92MP0004133_heterotaxia0.88391931
93MP0000762_abnormal_tongue_morphology0.87768704
94MP0004233_abnormal_muscle_weight0.86698724
95MP0005621_abnormal_cell_physiology0.86455937
96MP0003937_abnormal_limbs/digits/tail_de0.85155097
97MP0000467_abnormal_esophagus_morphology0.84497152
98MP0003115_abnormal_respiratory_system0.82956056
99MP0000858_altered_metastatic_potential0.82608988
100MP0002925_abnormal_cardiovascular_devel0.82370083
101MP0004185_abnormal_adipocyte_glucose0.82249244
102MP0005384_cellular_phenotype0.81969957
103MP0000477_abnormal_intestine_morphology0.81089325
104MP0000689_abnormal_spleen_morphology0.80230404
105MP0005409_darkened_coat_color0.80079678
106MP0002166_altered_tumor_susceptibility0.79784942
107MP0010234_abnormal_vibrissa_follicle0.79597308
108MP0003941_abnormal_skin_development0.79391737
109MP0004264_abnormal_extraembryonic_tissu0.78957473
110MP0003718_maternal_effect0.78869910
111MP0005670_abnormal_white_adipose0.76970617
112MP0009931_abnormal_skin_appearance0.76901465
113MP0000432_abnormal_head_morphology0.76659360
114MP0003300_gastrointestinal_ulcer0.75983291
115MP0000358_abnormal_cell_content/0.75953009
116MP0002269_muscular_atrophy0.75825547
117MP0003935_abnormal_craniofacial_develop0.74279872
118MP0005330_cardiomyopathy0.74082281
119MP0008770_decreased_survivor_rate0.73498594
120MP0002970_abnormal_white_adipose0.71752701
121MP0002210_abnormal_sex_determination0.70326334
122MP0005501_abnormal_skin_physiology0.70137731
123MP0000750_abnormal_muscle_regeneration0.69762358
124MP0003942_abnormal_urinary_system0.68235223
125MP0000627_abnormal_mammary_gland0.68120645
126MP0003221_abnormal_cardiomyocyte_apopto0.68057526
127MP0001145_abnormal_male_reproductive0.68023422
128MP0001286_abnormal_eye_development0.67769576
129MP0004381_abnormal_hair_follicle0.67518665
130MP0002429_abnormal_blood_cell0.65061250
131MP0006054_spinal_hemorrhage0.64679931
132MP0003303_peritoneal_inflammation0.63830407
133MP0000266_abnormal_heart_morphology0.63545890
134MP0005623_abnormal_meninges_morphology0.63309921
135MP0003448_altered_tumor_morphology0.59632997
136MP0003861_abnormal_nervous_system0.58769529
137MP0003315_abnormal_perineum_morphology0.58349621
138MP0003453_abnormal_keratinocyte_physiol0.55669770
139MP0002932_abnormal_joint_morphology0.55270911
140MP0003283_abnormal_digestive_organ0.54987036

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.25345050
2Selective tooth agenesis (HP:0001592)3.75552177
3Progressive muscle weakness (HP:0003323)3.44288098
4Medulloblastoma (HP:0002885)3.20879939
5Reticulocytopenia (HP:0001896)3.06998845
6Abnormality of the astrocytes (HP:0100707)3.02370650
7Astrocytoma (HP:0009592)3.02370650
8Colon cancer (HP:0003003)3.00987521
9Deviation of the thumb (HP:0009603)2.91956668
10Proximal placement of thumb (HP:0009623)2.91643476
11Broad face (HP:0000283)2.80891181
12Premature rupture of membranes (HP:0001788)2.80522003
13Birth length less than 3rd percentile (HP:0003561)2.78520279
14Distal lower limb amyotrophy (HP:0008944)2.78186855
15Abnormality of the anterior horn cell (HP:0006802)2.76072311
16Degeneration of anterior horn cells (HP:0002398)2.76072311
17Basal cell carcinoma (HP:0002671)2.72575003
18Achilles tendon contracture (HP:0001771)2.70672100
19Rhabdomyosarcoma (HP:0002859)2.67717499
20Dysmetric saccades (HP:0000641)2.64568359
21Microvesicular hepatic steatosis (HP:0001414)2.59093483
22Abnormality of the labia minora (HP:0012880)2.57230414
23Insomnia (HP:0100785)2.55708447
24Increased connective tissue (HP:0009025)2.54409890
25Breast hypoplasia (HP:0003187)2.50981196
26Increased nuchal translucency (HP:0010880)2.50466975
27Ragged-red muscle fibers (HP:0003200)2.49233483
28Urethral obstruction (HP:0000796)2.48437194
29Abnormal number of incisors (HP:0011064)2.48433881
30Glioma (HP:0009733)2.46897872
31Long palpebral fissure (HP:0000637)2.46721081
32Trismus (HP:0000211)2.46600635
33Agnosia (HP:0010524)2.45588163
34Chromsome breakage (HP:0040012)2.44945184
35Patellar aplasia (HP:0006443)2.44576243
36Aplasia/Hypoplasia of the patella (HP:0006498)2.38770114
37Abnormality of cells of the erythroid lineage (HP:0012130)2.38008168
38Missing ribs (HP:0000921)2.36850604
39Neoplasm of striated muscle (HP:0009728)2.35833086
40Neoplasm of the oral cavity (HP:0100649)2.34966259
41Oral leukoplakia (HP:0002745)2.34520587
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.33594522
43Absent radius (HP:0003974)2.33211571
44Abnormality of the Achilles tendon (HP:0005109)2.32348806
45Progressive external ophthalmoplegia (HP:0000590)2.27346334
46Disproportionate tall stature (HP:0001519)2.26962344
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26816735
48Hyperacusis (HP:0010780)2.23086314
49Neoplasm of the pancreas (HP:0002894)2.22558157
50Absent thumb (HP:0009777)2.22161552
51Short 4th metacarpal (HP:0010044)2.20118274
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20118274
53Abnormality of the calcaneus (HP:0008364)2.19126445
54Impulsivity (HP:0100710)2.18914377
55Increased density of long bones (HP:0006392)2.18418138
56Vertebral compression fractures (HP:0002953)2.17923593
57Pseudobulbar signs (HP:0002200)2.16073192
58Aplasia involving forearm bones (HP:0009822)2.15935541
59Absent forearm bone (HP:0003953)2.15935541
60Aplasia/hypoplasia of the humerus (HP:0006507)2.15474661
61Prominent nose (HP:0000448)2.15393078
62Ankyloglossia (HP:0010296)2.14783570
63Broad distal phalanx of finger (HP:0009836)2.12053804
64Atresia of the external auditory canal (HP:0000413)2.10494007
65Abnormal number of erythroid precursors (HP:0012131)2.09549534
66Testicular atrophy (HP:0000029)2.09509966
67Ectopic kidney (HP:0000086)2.09441953
68Biliary tract neoplasm (HP:0100574)2.08909885
69Amaurosis fugax (HP:0100576)2.08718896
70Carpal bone hypoplasia (HP:0001498)2.07331981
71Abnormality of oral frenula (HP:0000190)2.07097380
72Multiple enchondromatosis (HP:0005701)2.07053659
73Premature skin wrinkling (HP:0100678)2.07028350
74Abnormality of chromosome stability (HP:0003220)2.06348125
75Lower limb amyotrophy (HP:0007210)2.06316789
76Rough bone trabeculation (HP:0100670)2.06135103
77High pitched voice (HP:0001620)2.06108690
78Sparse lateral eyebrow (HP:0005338)2.04328616
79Abnormality of the umbilical cord (HP:0010881)2.04127759
80Septate vagina (HP:0001153)2.04086320
81Myelodysplasia (HP:0002863)2.03924725
82Skin tags (HP:0010609)2.02088456
83Squamous cell carcinoma (HP:0002860)2.01849604
84Abnormality of the distal phalanges of the toes (HP:0010182)2.01444320
85Short humerus (HP:0005792)2.01145465
86Meckel diverticulum (HP:0002245)2.00768906
87Distal upper limb amyotrophy (HP:0007149)2.00526205
88Upper limb amyotrophy (HP:0009129)2.00526205
89Stridor (HP:0010307)1.98152780
90Rib fusion (HP:0000902)1.98119698
91Short nail (HP:0001799)1.97657959
92Preauricular skin tag (HP:0000384)1.97375628
93Cafe-au-lait spot (HP:0000957)1.97132343
94Advanced eruption of teeth (HP:0006288)1.96431464
95Cholecystitis (HP:0001082)1.95838038
96Abnormal gallbladder physiology (HP:0012438)1.95838038
97Ankle contracture (HP:0006466)1.95726155
98Biconcave vertebral bodies (HP:0004586)1.95623945
99Overlapping toe (HP:0001845)1.95485436
100Pelvic girdle muscle weakness (HP:0003749)1.94709616
101Gastrointestinal carcinoma (HP:0002672)1.94306636
102Malignant gastrointestinal tract tumors (HP:0006749)1.94306636
103Angiofibromas (HP:0010615)1.93074699
104Adenoma sebaceum (HP:0009720)1.93074699
105Natal tooth (HP:0000695)1.92078688
106Abnormality of the ileum (HP:0001549)1.91939276
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.91879181
108Fragile skin (HP:0001030)1.91111627
109Esophageal atresia (HP:0002032)1.91012433
110Long eyelashes (HP:0000527)1.90682084
111Protrusio acetabuli (HP:0003179)1.90408081
112Elbow flexion contracture (HP:0002987)1.90293946
113Cerebral aneurysm (HP:0004944)1.89781817
114Pointed chin (HP:0000307)1.89719511
115Facial hemangioma (HP:0000329)1.87079918
116Renal duplication (HP:0000075)1.86892764
117Overriding aorta (HP:0002623)1.86869034
118Patellar dislocation (HP:0002999)1.86647818
119Generalized amyotrophy (HP:0003700)1.86258379
120Asymmetry of the thorax (HP:0001555)1.85029703
121Elfin facies (HP:0004428)1.83975786
122Abnormality of the preputium (HP:0100587)1.83907970
12311 pairs of ribs (HP:0000878)1.83372612
124Tracheoesophageal fistula (HP:0002575)1.82307732
125Myopathic facies (HP:0002058)1.81381617
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.81006843
127Abnormality of the salivary glands (HP:0010286)1.80903879
128Skull defect (HP:0001362)1.79999968
129Dislocated radial head (HP:0003083)1.79408814
130Distal lower limb muscle weakness (HP:0009053)1.78924542
131Thrombocytosis (HP:0001894)1.78737038
132Difficulty climbing stairs (HP:0003551)1.77790545
133Back pain (HP:0003418)1.77759836
134Macrocytic anemia (HP:0001972)1.77105362
135Obstructive sleep apnea (HP:0002870)1.75812278
136Volvulus (HP:0002580)1.75294202
137High anterior hairline (HP:0009890)1.75163933
138Shallow orbits (HP:0000586)1.74534280
139Small intestinal stenosis (HP:0012848)1.74479410
140Duodenal stenosis (HP:0100867)1.74479410
141Ulnar bowing (HP:0003031)1.73878285
142Self-mutilation (HP:0000742)1.73836126
143Deep palmar crease (HP:0006191)1.73118406
144Osteolytic defects of the hand bones (HP:0009699)1.73117721
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.73117721
146Cutaneous melanoma (HP:0012056)1.72009047
147Premature graying of hair (HP:0002216)1.71861021
148Flat acetabular roof (HP:0003180)1.71718125
149Glossoptosis (HP:0000162)1.71689426
150Spinal rigidity (HP:0003306)1.71456994
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.70811678
152Spastic diplegia (HP:0001264)1.69705058
153Reduced subcutaneous adipose tissue (HP:0003758)1.69264055
154Pallor (HP:0000980)1.68650975
155Cerebral hypomyelination (HP:0006808)1.67452286
156Horseshoe kidney (HP:0000085)1.67171088
157Abdominal situs inversus (HP:0003363)1.66950296
158Abnormality of abdominal situs (HP:0011620)1.66950296
159Supernumerary spleens (HP:0009799)1.64870282
160Spinal muscular atrophy (HP:0007269)1.64630639
161Genu recurvatum (HP:0002816)1.63891711
162Syringomyelia (HP:0003396)1.63780512
163Spinal cord lesions (HP:0100561)1.63780512
164Entropion (HP:0000621)1.63568697
165Abnormality of the thoracic spine (HP:0100711)1.61143539
166Abnormality of the radial head (HP:0003995)1.61017378
167Abnormality of the fingertips (HP:0001211)1.59941015
168Premature ovarian failure (HP:0008209)1.58901222
169Ureteral duplication (HP:0000073)1.57093772
170Mitral regurgitation (HP:0001653)1.56154600
171Bowed forearm bones (HP:0003956)1.53462352
172Bowing of the arm (HP:0006488)1.53462352
173Spinal cord compression (HP:0002176)1.52933558
174Progressive hearing impairment (HP:0001730)1.50289757
175Poikiloderma (HP:0001029)1.49633975
176Persistence of primary teeth (HP:0006335)1.49188314
177Arnold-Chiari malformation (HP:0002308)1.47749160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG15.00648660
2CDK123.76999272
3EEF2K3.66213060
4CDC73.61132357
5BUB13.06097695
6WEE12.97909787
7TSSK62.70491380
8IRAK32.69661105
9NEK22.59104865
10PKN22.42564509
11PRPF4B2.39145452
12MAP3K102.27949997
13SIK12.16722738
14RPS6KB22.14268534
15TTK2.10210817
16PASK2.07599679
17EPHA22.05928115
18TRIB32.05471802
19NEK12.00865273
20EIF2AK11.78503457
21STK101.74530673
22CDK71.73350875
23CDK41.67803248
24ALK1.65892749
25TESK21.65512725
26MAP3K81.62213576
27MST1R1.61411846
28SCYL21.61394211
29BRD41.55311904
30VRK21.50852283
31PLK11.50097862
32SRPK11.49447357
33MKNK11.47488005
34ATR1.42674146
35RPS6KA41.34761318
36PAK41.33805485
37TTN1.28752282
38* CHEK11.28511450
39TGFBR11.27893395
40MAP4K11.27827506
41NME21.26010838
42FGFR41.25810859
43MTOR1.23114854
44* AURKB1.21542112
45LRRK21.14281114
46CAMK1D1.11044507
47CHEK21.10240807
48PLK31.08207189
49FLT31.06916604
50BRSK21.06133162
51MKNK21.06090183
52PRKD31.04686104
53CDK61.03997689
54TLK11.01999081
55MAP2K30.98972441
56PAK20.98435657
57ICK0.96334163
58CDK20.95930078
59LATS20.92042821
60MAP3K130.91925277
61MAPK110.90873290
62ACVR1B0.90586838
63ARAF0.90025048
64PLK40.88218041
65ATM0.87816884
66PIM10.87013694
67PTK20.86370159
68LATS10.85425847
69TAF10.84567267
70PTK60.83677112
71DYRK30.82562868
72BRAF0.82421908
73STK40.79421266
74CAMK1G0.78925763
75STK30.77802806
76CDK90.77640898
77IRAK20.75825929
78FGFR10.74970769
79BMX0.74559936
80PNCK0.70534673
81PDGFRA0.70031148
82LMTK20.69309528
83PAK10.67881520
84EIF2AK30.67551993
85PBK0.67531659
86CDK80.67371247
87* AURKA0.65132574
88CSNK2A20.62574497
89CSNK1E0.61973548
90AKT20.60574420
91MAP3K110.60491008
92* CDK10.59413372
93MAP3K90.58650555
94BRSK10.58643875
95JAK30.57973864
96PRKD20.57657675
97MAPKAPK30.56975588
98GRK60.56433606
99ZAP700.54784943
100TAOK20.53626382
101MELK0.52769451
102DAPK10.48646595
103ERN10.48225968
104RAF10.48067003
105TESK10.47776547
106PRKCI0.47759380
107MAP2K20.46530011
108KSR20.46312995
109CSNK1D0.46174492
110PRKDC0.44522478
111NTRK10.44246515
112PIM20.42489245
113TAOK10.42153457
114CHUK0.40503553
115MAP3K30.39898865
116NME10.39824212
117MARK20.39277105
118VRK10.37849421
119CSNK2A10.37784785
120PDPK10.37442074
121MAP3K10.36843224
122RPS6KA20.36755549
123MAPK140.36278676
124RPS6KC10.35757120
125RPS6KL10.35757120
126CDC42BPA0.35564856
127RPS6KA10.35099138
128ERBB40.33770629
129BTK0.33464688
130MET0.32996218
131KDR0.32505518
132* MAPK10.30551576
133RIPK10.29210178
134AKT10.29097681
135MAPKAPK20.28572677
136CLK10.27289579
137ILK0.27204805

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19773379
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76455876
3Mismatch repair_Homo sapiens_hsa034303.57169052
4One carbon pool by folate_Homo sapiens_hsa006703.52691100
5RNA transport_Homo sapiens_hsa030133.41516037
6Spliceosome_Homo sapiens_hsa030403.30594436
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95779175
8Base excision repair_Homo sapiens_hsa034102.61370887
9Cell cycle_Homo sapiens_hsa041102.59292007
10Ribosome_Homo sapiens_hsa030102.46270255
11Nucleotide excision repair_Homo sapiens_hsa034202.37195198
12RNA polymerase_Homo sapiens_hsa030202.24790355
13Homologous recombination_Homo sapiens_hsa034402.21250607
14mRNA surveillance pathway_Homo sapiens_hsa030152.12068389
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07491025
16Pyrimidine metabolism_Homo sapiens_hsa002401.68712950
17Fanconi anemia pathway_Homo sapiens_hsa034601.67504632
18RNA degradation_Homo sapiens_hsa030181.64537383
19Proteasome_Homo sapiens_hsa030501.64336620
20p53 signaling pathway_Homo sapiens_hsa041151.60382865
21Non-homologous end-joining_Homo sapiens_hsa034501.56178436
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49348148
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.32422124
24Viral carcinogenesis_Homo sapiens_hsa052031.31176422
25Biosynthesis of amino acids_Homo sapiens_hsa012301.29737040
26Epstein-Barr virus infection_Homo sapiens_hsa051691.24991656
27Basal transcription factors_Homo sapiens_hsa030221.21102152
28Antigen processing and presentation_Homo sapiens_hsa046121.17432887
29MicroRNAs in cancer_Homo sapiens_hsa052061.15785249
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15019665
31Galactose metabolism_Homo sapiens_hsa000521.14843312
32Selenocompound metabolism_Homo sapiens_hsa004501.11290815
33HTLV-I infection_Homo sapiens_hsa051661.09503769
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04446649
35Small cell lung cancer_Homo sapiens_hsa052221.03758249
36Chronic myeloid leukemia_Homo sapiens_hsa052201.01020903
37Herpes simplex infection_Homo sapiens_hsa051681.00661058
38Glioma_Homo sapiens_hsa052140.98447312
39Other glycan degradation_Homo sapiens_hsa005110.98203828
40Systemic lupus erythematosus_Homo sapiens_hsa053220.98197538
41N-Glycan biosynthesis_Homo sapiens_hsa005100.97440227
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96802890
43Notch signaling pathway_Homo sapiens_hsa043300.96450279
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.94183667
45Thyroid cancer_Homo sapiens_hsa052160.93311472
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90731582
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.90529531
48VEGF signaling pathway_Homo sapiens_hsa043700.89794928
49Pentose phosphate pathway_Homo sapiens_hsa000300.87946223
50Insulin signaling pathway_Homo sapiens_hsa049100.87466631
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86674518
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85679983
53Hippo signaling pathway_Homo sapiens_hsa043900.84692205
54Bladder cancer_Homo sapiens_hsa052190.84009678
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82495776
56Basal cell carcinoma_Homo sapiens_hsa052170.82255799
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79618756
58Oocyte meiosis_Homo sapiens_hsa041140.79304289
59Lysine degradation_Homo sapiens_hsa003100.79196267
60AMPK signaling pathway_Homo sapiens_hsa041520.76757388
61Prion diseases_Homo sapiens_hsa050200.76631247
62Acute myeloid leukemia_Homo sapiens_hsa052210.75886417
63mTOR signaling pathway_Homo sapiens_hsa041500.75277189
64Adherens junction_Homo sapiens_hsa045200.72639631
65Legionellosis_Homo sapiens_hsa051340.71480004
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71263193
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70099527
68Purine metabolism_Homo sapiens_hsa002300.69632835
69Colorectal cancer_Homo sapiens_hsa052100.69352027
70Viral myocarditis_Homo sapiens_hsa054160.68796165
71Sulfur relay system_Homo sapiens_hsa041220.67341367
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67034149
73ErbB signaling pathway_Homo sapiens_hsa040120.66736727
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66287131
75Apoptosis_Homo sapiens_hsa042100.65860931
76TGF-beta signaling pathway_Homo sapiens_hsa043500.64563945
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64276766
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63343539
79Carbon metabolism_Homo sapiens_hsa012000.62067843
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60813384
81HIF-1 signaling pathway_Homo sapiens_hsa040660.60100087
82Proteoglycans in cancer_Homo sapiens_hsa052050.59857021
83Pyruvate metabolism_Homo sapiens_hsa006200.57487103
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.57225454
85Hepatitis B_Homo sapiens_hsa051610.56309953
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.54753434
87Primary immunodeficiency_Homo sapiens_hsa053400.54717361
88Glucagon signaling pathway_Homo sapiens_hsa049220.52505593
89Shigellosis_Homo sapiens_hsa051310.52244735
90Non-small cell lung cancer_Homo sapiens_hsa052230.51198700
91Alcoholism_Homo sapiens_hsa050340.50731886
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50313171
93Measles_Homo sapiens_hsa051620.49023051
94Inositol phosphate metabolism_Homo sapiens_hsa005620.48607275
95Pathways in cancer_Homo sapiens_hsa052000.47572287
96Prostate cancer_Homo sapiens_hsa052150.46659730
97Hedgehog signaling pathway_Homo sapiens_hsa043400.46283300
98Melanoma_Homo sapiens_hsa052180.45119395
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44934224
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43704377
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43553444
102Arginine biosynthesis_Homo sapiens_hsa002200.43450131
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42847215
104Arginine and proline metabolism_Homo sapiens_hsa003300.42165505
105Hepatitis C_Homo sapiens_hsa051600.40630395
106Vitamin B6 metabolism_Homo sapiens_hsa007500.40369262
107Endometrial cancer_Homo sapiens_hsa052130.39512485
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39291718
109Folate biosynthesis_Homo sapiens_hsa007900.38902591
110Pancreatic cancer_Homo sapiens_hsa052120.37614493
111T cell receptor signaling pathway_Homo sapiens_hsa046600.37403219
112Tight junction_Homo sapiens_hsa045300.36661364
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.36472326
114B cell receptor signaling pathway_Homo sapiens_hsa046620.34150930
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32250662
116Influenza A_Homo sapiens_hsa051640.31809819
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31670664
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.31626813
119Focal adhesion_Homo sapiens_hsa045100.30815591
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30681089
121Fructose and mannose metabolism_Homo sapiens_hsa000510.29414208
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29147998
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27647417
124Toxoplasmosis_Homo sapiens_hsa051450.26592693
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26546407
126Wnt signaling pathway_Homo sapiens_hsa043100.26471442
127Renal cell carcinoma_Homo sapiens_hsa052110.24345776

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