MYBL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.23422230
2regulation of gene silencing by miRNA (GO:0060964)5.23422230
3regulation of gene silencing by RNA (GO:0060966)5.23422230
4DNA replication initiation (GO:0006270)5.04445474
5DNA unwinding involved in DNA replication (GO:0006268)4.89501633
6nuclear pore organization (GO:0006999)4.77657099
7protein localization to kinetochore (GO:0034501)4.71695384
8DNA replication-dependent nucleosome assembly (GO:0006335)4.66781961
9DNA replication-dependent nucleosome organization (GO:0034723)4.66781961
10DNA strand elongation involved in DNA replication (GO:0006271)4.53766684
11folic acid-containing compound biosynthetic process (GO:0009396)4.53484565
12nuclear pore complex assembly (GO:0051292)4.52344391
13mitotic sister chromatid cohesion (GO:0007064)4.43368766
14DNA strand elongation (GO:0022616)4.30467344
15mitotic metaphase plate congression (GO:0007080)4.28538584
16nucleobase biosynthetic process (GO:0046112)4.27652828
17mitotic nuclear envelope disassembly (GO:0007077)4.26555548
18mitotic sister chromatid segregation (GO:0000070)4.19293578
19DNA replication checkpoint (GO:0000076)4.18626902
20regulation of helicase activity (GO:0051095)4.13528296
21formation of translation preinitiation complex (GO:0001731)4.12323975
22somatic hypermutation of immunoglobulin genes (GO:0016446)4.11071885
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.11071885
24IMP biosynthetic process (GO:0006188)4.09670470
25telomere maintenance via semi-conservative replication (GO:0032201)4.03591756
26ribosomal small subunit biogenesis (GO:0042274)4.03200572
27nuclear envelope disassembly (GO:0051081)3.96392944
28membrane disassembly (GO:0030397)3.96392944
29establishment of integrated proviral latency (GO:0075713)3.95320296
30protein localization to chromosome, centromeric region (GO:0071459)3.93974022
31chromosome condensation (GO:0030261)3.87957748
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.86601178
33DNA topological change (GO:0006265)3.83347412
34purine nucleobase biosynthetic process (GO:0009113)3.83127616
35heterochromatin organization (GO:0070828)3.79906523
36regulation of histone H3-K9 methylation (GO:0051570)3.79831737
37DNA duplex unwinding (GO:0032508)3.73894407
38DNA geometric change (GO:0032392)3.73690435
39sister chromatid segregation (GO:0000819)3.73153866
40protein K6-linked ubiquitination (GO:0085020)3.73041632
41maturation of SSU-rRNA (GO:0030490)3.71957129
42protein complex localization (GO:0031503)3.69887718
43metaphase plate congression (GO:0051310)3.68555911
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67067154
45negative regulation of histone methylation (GO:0031061)3.66268440
46ribosome assembly (GO:0042255)3.64542843
47positive regulation of chromosome segregation (GO:0051984)3.63978651
48determination of adult lifespan (GO:0008340)3.62369595
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61178226
50IMP metabolic process (GO:0046040)3.57462373
51telomere maintenance via recombination (GO:0000722)3.55071757
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.53177298
53pre-miRNA processing (GO:0031054)3.52474081
54ribosome biogenesis (GO:0042254)3.51781127
55regulation of translational fidelity (GO:0006450)3.50147323
56pore complex assembly (GO:0046931)3.46812198
57mitotic recombination (GO:0006312)3.45962603
58telomere maintenance via telomere lengthening (GO:0010833)3.44420536
59mitotic chromosome condensation (GO:0007076)3.43374359
60regulation of gene silencing (GO:0060968)3.40360105
61regulation of spindle organization (GO:0090224)3.39576052
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.39115487
63chromatin remodeling at centromere (GO:0031055)3.37305663
64negative regulation of mRNA processing (GO:0050686)3.36846738
65DNA packaging (GO:0006323)3.34106902
66histone H4-K12 acetylation (GO:0043983)3.32413216
67ribosomal small subunit assembly (GO:0000028)3.31827524
68establishment of chromosome localization (GO:0051303)3.30047932
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.28685636
70regulation of telomere maintenance via telomerase (GO:0032210)3.26447128
71L-serine metabolic process (GO:0006563)3.23981289
72histone arginine methylation (GO:0034969)3.23732485
73DNA synthesis involved in DNA repair (GO:0000731)3.22279465
74chromatin assembly (GO:0031497)3.21791097
75proline biosynthetic process (GO:0006561)3.21190530
76negative regulation of mRNA metabolic process (GO:1903312)3.20497207
77kinetochore organization (GO:0051383)3.20146078
78cellular protein complex localization (GO:0034629)3.18745804
79ribonucleoprotein complex biogenesis (GO:0022613)3.18266102
80regulation of centrosome cycle (GO:0046605)3.16479383
81negative regulation of RNA splicing (GO:0033119)3.16361617
82positive regulation of SMAD protein import into nucleus (GO:0060391)3.16006144
83CENP-A containing nucleosome assembly (GO:0034080)3.15871172
84DNA replication-independent nucleosome organization (GO:0034724)3.15117726
85DNA replication-independent nucleosome assembly (GO:0006336)3.15117726
86attachment of spindle microtubules to kinetochore (GO:0008608)3.14759899
87regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14571952
88negative regulation of gene silencing (GO:0060969)3.13843603
89regulation of mitotic spindle organization (GO:0060236)3.13438239
90paraxial mesoderm development (GO:0048339)3.12222111
91viral mRNA export from host cell nucleus (GO:0046784)3.08705084
92chromatin assembly or disassembly (GO:0006333)3.08047356
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07121590
94regulation of translational termination (GO:0006449)3.06902671
95regulation of chromosome segregation (GO:0051983)3.05821394
96nuclear envelope organization (GO:0006998)3.04958088
97mismatch repair (GO:0006298)3.04097837
98peptidyl-arginine omega-N-methylation (GO:0035247)3.04084110
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02703581
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02703581
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.02703581
102kinetochore assembly (GO:0051382)3.00480001
103histone H2A monoubiquitination (GO:0035518)3.00009767
104ribosomal large subunit biogenesis (GO:0042273)2.98816733
105rRNA processing (GO:0006364)2.98732065
106rRNA transcription (GO:0009303)2.98481043
107negative regulation of chromosome segregation (GO:0051985)2.97791000
108nucleobase-containing small molecule interconversion (GO:0015949)2.96610208
109establishment of viral latency (GO:0019043)2.96078027
110regulation of sister chromatid cohesion (GO:0007063)2.96067095
111DNA conformation change (GO:0071103)2.95229746
112protein localization to chromosome (GO:0034502)2.95040142
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.94752361
114non-recombinational repair (GO:0000726)2.92503339
115double-strand break repair via nonhomologous end joining (GO:0006303)2.92503339
116protein-DNA complex disassembly (GO:0032986)2.91197925
117nucleosome disassembly (GO:0006337)2.91197925
118DNA ligation (GO:0006266)2.90900480
119translational initiation (GO:0006413)2.90822405
120rRNA metabolic process (GO:0016072)2.90349548
121folic acid metabolic process (GO:0046655)2.90006667
122viral transcription (GO:0019083)2.89936024
123positive regulation of DNA-dependent DNA replication (GO:2000105)2.89791217
124base-excision repair (GO:0006284)2.89202510
125meiotic chromosome segregation (GO:0045132)2.88119184
126spindle checkpoint (GO:0031577)2.86527805
127histone exchange (GO:0043486)2.85817912
128spliceosomal snRNP assembly (GO:0000387)2.83486676
129chromosome segregation (GO:0007059)2.83239590
130ATP-dependent chromatin remodeling (GO:0043044)2.83088764
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82677461
132nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80978335
133regulation of RNA export from nucleus (GO:0046831)2.80853537
134translational termination (GO:0006415)2.79864067
135peptidyl-arginine N-methylation (GO:0035246)2.77579347
136peptidyl-arginine methylation (GO:0018216)2.77579347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25063386
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.33579157
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96762342
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50241395
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16044594
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01725609
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96080986
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.74416121
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.74416121
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.74416121
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.72927666
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71855054
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62176136
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46278460
15* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.36784286
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22565618
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10163326
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08970166
19POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08295529
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07903399
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07036278
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.06053219
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.05851166
24* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.01529373
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99974768
26XRN2_22483619_ChIP-Seq_HELA_Human1.97937226
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92173595
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91685341
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.90578246
30* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90371604
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.88687757
32* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85363307
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84045903
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83568565
35AR_21909140_ChIP-Seq_LNCAP_Human1.82828117
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81841223
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81126784
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80518505
39* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79664310
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.71225468
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70201734
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.64017747
43* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63030291
44VDR_21846776_ChIP-Seq_THP-1_Human1.60804630
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57839917
46VDR_23849224_ChIP-Seq_CD4+_Human1.57216124
47* MYC_22102868_ChIP-Seq_BL_Human1.54469098
48* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54418836
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53816177
50* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51483678
51* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50776150
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50615968
53TTF2_22483619_ChIP-Seq_HELA_Human1.45710693
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45379328
55FOXP3_21729870_ChIP-Seq_TREG_Human1.44416280
56* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44255705
57DCP1A_22483619_ChIP-Seq_HELA_Human1.43307618
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42686212
59* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39815602
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.39542199
61* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38574704
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37182060
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35824373
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35543071
65* GABP_19822575_ChIP-Seq_HepG2_Human1.35175241
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33499136
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31497196
68CIITA_25753668_ChIP-Seq_RAJI_Human1.30863193
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30319867
70* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29875553
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.28726154
72* KDM5A_27292631_Chip-Seq_BREAST_Human1.28294931
73* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24420446
74* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20239078
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19763148
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18762693
77* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18340897
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17263200
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.14817717
80* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14213184
81* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14126162
82TFEB_21752829_ChIP-Seq_HELA_Human1.11809576
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11590414
84* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11283869
85* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10563478
86RACK7_27058665_Chip-Seq_MCF-7_Human1.07074224
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05912880
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05897095
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05778228
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04340270
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03606521
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02816642
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02763665
94* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02612867
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02110483
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01749794
97* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01534544
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00278094
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.99280837
100TET1_21451524_ChIP-Seq_MESCs_Mouse0.99163001
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99097923
102ELK1_19687146_ChIP-ChIP_HELA_Human0.98653845
103LXR_22292898_ChIP-Seq_THP-1_Human0.98458755
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98228112
105ZNF263_19887448_ChIP-Seq_K562_Human0.97162131
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96861242
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96678546
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96114619
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96098249
110* KAP1_27257070_Chip-Seq_ESCs_Mouse0.96010512
111* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95425649
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95325752
113ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94168005
114CHD1_26751641_Chip-Seq_LNCaP_Human0.92848843
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92429361
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90181790
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87674384
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86874585
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86636501
120* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85819186
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84581579
122* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83408325
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83373963
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83089141
125ATF3_27146783_Chip-Seq_COLON_Human0.82293343
126* NCOR1_26117541_ChIP-Seq_K562_Human0.81895491
127TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81838796
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81791193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.90273510
2MP0003111_abnormal_nucleus_morphology4.76087682
3MP0010094_abnormal_chromosome_stability4.67491790
4MP0008057_abnormal_DNA_replication4.48955393
5* MP0004957_abnormal_blastocyst_morpholog4.35367098
6* MP0003077_abnormal_cell_cycle3.80942026
7MP0008058_abnormal_DNA_repair3.18037677
8MP0010352_gastrointestinal_tract_polyps2.81240807
9MP0001730_embryonic_growth_arrest2.68186783
10MP0000350_abnormal_cell_proliferation2.56057098
11MP0008932_abnormal_embryonic_tissue2.49577884
12MP0002653_abnormal_ependyma_morphology2.47806174
13MP0003806_abnormal_nucleotide_metabolis2.44993205
14MP0010307_abnormal_tumor_latency2.30905986
15MP0008007_abnormal_cellular_replicative2.30200401
16MP0003123_paternal_imprinting2.24671876
17MP0004133_heterotaxia2.14915367
18MP0001672_abnormal_embryogenesis/_devel2.12041833
19MP0005380_embryogenesis_phenotype2.12041833
20MP0002084_abnormal_developmental_patter2.08170374
21* MP0002085_abnormal_embryonic_tissue2.03892256
22MP0001697_abnormal_embryo_size2.01963359
23MP0003786_premature_aging1.91965258
24MP0005076_abnormal_cell_differentiation1.91478309
25MP0002086_abnormal_extraembryonic_tissu1.89378148
26MP0003984_embryonic_growth_retardation1.84483048
27MP0004197_abnormal_fetal_growth/weight/1.83621074
28MP0002088_abnormal_embryonic_growth/wei1.81048334
29* MP0002080_prenatal_lethality1.78362489
30MP0001346_abnormal_lacrimal_gland1.77040584
31MP0008877_abnormal_DNA_methylation1.76138778
32MP0003718_maternal_effect1.69710982
33MP0003136_yellow_coat_color1.69701574
34MP0005451_abnormal_body_composition1.62854574
35MP0003119_abnormal_digestive_system1.55314018
36MP0003890_abnormal_embryonic-extraembry1.54873132
37MP0000490_abnormal_crypts_of1.53716361
38MP0001293_anophthalmia1.50182796
39MP0000566_synostosis1.46711092
40MP0003941_abnormal_skin_development1.44597414
41MP0002796_impaired_skin_barrier1.43695234
42MP0003283_abnormal_digestive_organ1.42647525
43MP0003567_abnormal_fetal_cardiomyocyte1.42526975
44MP0002396_abnormal_hematopoietic_system1.41497242
45MP0000313_abnormal_cell_death1.37245833
46MP0003121_genomic_imprinting1.36459013
47MP0003705_abnormal_hypodermis_morpholog1.31709775
48MP0002019_abnormal_tumor_incidence1.31702788
49MP0002210_abnormal_sex_determination1.27136124
50MP0010030_abnormal_orbit_morphology1.26174297
51MP0003566_abnormal_cell_adhesion1.22895769
52MP0002163_abnormal_gland_morphology1.22711962
53MP0006292_abnormal_olfactory_placode1.21790342
54MP0001145_abnormal_male_reproductive1.19258508
55MP0001849_ear_inflammation1.15717482
56MP0000678_abnormal_parathyroid_gland1.14399827
57MP0001661_extended_life_span1.10914538
58MP0004264_abnormal_extraembryonic_tissu1.10169059
59MP0006035_abnormal_mitochondrial_morpho1.08906343
60MP0000537_abnormal_urethra_morphology1.06622376
61MP0001929_abnormal_gametogenesis0.99166018
62MP0002111_abnormal_tail_morphology0.98485369
63MP0005623_abnormal_meninges_morphology0.97744722
64MP0000653_abnormal_sex_gland0.94502442
65MP0008260_abnormal_autophagy0.93719561
66MP0009053_abnormal_anal_canal0.93570681
67MP0003315_abnormal_perineum_morphology0.93114590
68MP0005023_abnormal_wound_healing0.92912370
69MP0002009_preneoplasia0.91463808
70MP0009703_decreased_birth_body0.90682647
71MP0009697_abnormal_copulation0.88707979
72MP0003937_abnormal_limbs/digits/tail_de0.87782659
73MP0001915_intracranial_hemorrhage0.87474834
74MP0005266_abnormal_metabolism0.87132375
75MP0005384_cellular_phenotype0.85903874
76MP0005621_abnormal_cell_physiology0.85573870
77MP0001286_abnormal_eye_development0.85024741
78MP0005666_abnormal_adipose_tissue0.83422278
79MP0005501_abnormal_skin_physiology0.83148608
80MP0009278_abnormal_bone_marrow0.83121156
81MP0000358_abnormal_cell_content/0.82514695
82MP0003861_abnormal_nervous_system0.81352285
83MP0005397_hematopoietic_system_phenotyp0.80668249
84MP0001545_abnormal_hematopoietic_system0.80668249
85MP0009379_abnormal_foot_pigmentation0.80319680
86MP0009672_abnormal_birth_weight0.79828626
87MP0002697_abnormal_eye_size0.79671049
88MP0003942_abnormal_urinary_system0.79345210
89MP0002098_abnormal_vibrissa_morphology0.79324299
90MP0002089_abnormal_postnatal_growth/wei0.78467399
91MP0010234_abnormal_vibrissa_follicle0.77243592
92MP0002092_abnormal_eye_morphology0.76624427
93MP0003453_abnormal_keratinocyte_physiol0.76049234
94MP0001348_abnormal_lacrimal_gland0.74200677
95MP0003115_abnormal_respiratory_system0.72622755
96MP0002160_abnormal_reproductive_system0.72539694
97MP0008770_decreased_survivor_rate0.71742465
98MP0000003_abnormal_adipose_tissue0.71182473
99MP0003943_abnormal_hepatobiliary_system0.71126868
100MP0000858_altered_metastatic_potential0.70026551
101MP0000477_abnormal_intestine_morphology0.69819511
102MP0000432_abnormal_head_morphology0.69602064
103MP0000703_abnormal_thymus_morphology0.69369462
104MP0002877_abnormal_melanocyte_morpholog0.69358196
105MP0000371_diluted_coat_color0.68901211
106MP0003935_abnormal_craniofacial_develop0.67497608
107MP0000733_abnormal_muscle_development0.67250994
108MP0003936_abnormal_reproductive_system0.66623784
109MP0004185_abnormal_adipocyte_glucose0.66013567
110MP0010630_abnormal_cardiac_muscle0.65988707
111MP0000462_abnormal_digestive_system0.65748205
112MP0005367_renal/urinary_system_phenotyp0.65662345
113MP0000516_abnormal_urinary_system0.65662345
114MP0002925_abnormal_cardiovascular_devel0.65658342
115MP0002249_abnormal_larynx_morphology0.65604373
116MP0004808_abnormal_hematopoietic_stem0.65579009
117MP0000428_abnormal_craniofacial_morphol0.62817369
118MP0001119_abnormal_female_reproductive0.62497510
119MP0002075_abnormal_coat/hair_pigmentati0.61770240
120MP0005389_reproductive_system_phenotype0.60213128
121MP0004233_abnormal_muscle_weight0.58257063
122MP0009333_abnormal_splenocyte_physiolog0.56272046
123MP0002161_abnormal_fertility/fecundity0.54927395
124MP0003699_abnormal_female_reproductive0.54910488
125MP0003698_abnormal_male_reproductive0.54651907
126MP0002722_abnormal_immune_system0.53784907

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.47542826
2Birth length less than 3rd percentile (HP:0003561)4.64888689
3Abnormality of the labia minora (HP:0012880)4.31342236
4Breast hypoplasia (HP:0003187)4.18662111
5Chromsome breakage (HP:0040012)4.08283933
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07377675
7Medulloblastoma (HP:0002885)3.99642370
8Astrocytoma (HP:0009592)3.78926652
9Abnormality of the astrocytes (HP:0100707)3.78926652
10Agnosia (HP:0010524)3.75148559
11Absent radius (HP:0003974)3.67408401
12Selective tooth agenesis (HP:0001592)3.61380760
13Neoplasm of the oral cavity (HP:0100649)3.57738709
14Aplasia involving forearm bones (HP:0009822)3.45487524
15Absent forearm bone (HP:0003953)3.45487524
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.44597927
17Rhabdomyosarcoma (HP:0002859)3.43932214
18Reticulocytopenia (HP:0001896)3.33140399
19Supernumerary spleens (HP:0009799)3.28553389
20Colon cancer (HP:0003003)3.25813500
21Glioma (HP:0009733)3.23765609
22Patellar aplasia (HP:0006443)3.22064713
23Impulsivity (HP:0100710)3.18324790
24Progressive muscle weakness (HP:0003323)3.03660801
25Abnormality of chromosome stability (HP:0003220)3.01630315
26Carpal bone hypoplasia (HP:0001498)2.99065224
27Aplasia/Hypoplasia of the patella (HP:0006498)2.96426225
28Absent thumb (HP:0009777)2.95286290
29Microvesicular hepatic steatosis (HP:0001414)2.94128500
30Meckel diverticulum (HP:0002245)2.94119595
31Rib fusion (HP:0000902)2.93195651
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.92991967
33Oral leukoplakia (HP:0002745)2.91594965
34Aplasia/hypoplasia of the humerus (HP:0006507)2.90531591
35Abnormality of the ileum (HP:0001549)2.87468813
36Neoplasm of striated muscle (HP:0009728)2.85291924
37Abnormality of the preputium (HP:0100587)2.82634102
38Missing ribs (HP:0000921)2.78521840
39Hyperacusis (HP:0010780)2.76298643
40Abnormal number of incisors (HP:0011064)2.74158054
41Septate vagina (HP:0001153)2.73249090
42Basal cell carcinoma (HP:0002671)2.73012322
43Short humerus (HP:0005792)2.70616333
44Abnormality of abdominal situs (HP:0011620)2.63080679
45Abdominal situs inversus (HP:0003363)2.63080679
46Esophageal atresia (HP:0002032)2.62814617
47Degeneration of anterior horn cells (HP:0002398)2.62403066
48Abnormality of the anterior horn cell (HP:0006802)2.62403066
49Shawl scrotum (HP:0000049)2.53895011
50Broad distal phalanx of finger (HP:0009836)2.50928070
51Biliary tract neoplasm (HP:0100574)2.50634449
52Duplicated collecting system (HP:0000081)2.47410258
53Abnormality of cochlea (HP:0000375)2.47311236
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46218060
55Proximal placement of thumb (HP:0009623)2.45636707
56Duodenal stenosis (HP:0100867)2.45394113
57Small intestinal stenosis (HP:0012848)2.45394113
58Rough bone trabeculation (HP:0100670)2.43695073
59Duplication of thumb phalanx (HP:0009942)2.43661805
60Cerebral hypomyelination (HP:0006808)2.41358084
61Neoplasm of the pancreas (HP:0002894)2.41014071
62Abnormality of the salivary glands (HP:0010286)2.39143355
63Deviation of the thumb (HP:0009603)2.38824421
64Abnormality of reticulocytes (HP:0004312)2.36688837
65Abnormality of cells of the erythroid lineage (HP:0012130)2.33643327
66Myelodysplasia (HP:0002863)2.31831496
67Tracheoesophageal fistula (HP:0002575)2.31057320
68Premature ovarian failure (HP:0008209)2.30533396
69Amaurosis fugax (HP:0100576)2.24689181
70Ectopic kidney (HP:0000086)2.21305445
71Horseshoe kidney (HP:0000085)2.20442277
72Cafe-au-lait spot (HP:0000957)2.20376053
73Sloping forehead (HP:0000340)2.19113177
74Facial hemangioma (HP:0000329)2.17803744
75Abnormality of the duodenum (HP:0002246)2.17624073
76Bone marrow hypocellularity (HP:0005528)2.12295380
77Overlapping toe (HP:0001845)2.12269766
78Rectovaginal fistula (HP:0000143)2.11473479
79Rectal fistula (HP:0100590)2.11473479
80Insomnia (HP:0100785)2.11111043
81Asplenia (HP:0001746)2.09652506
82Atresia of the external auditory canal (HP:0000413)2.08960233
83Abnormal gallbladder physiology (HP:0012438)2.08553326
84Cholecystitis (HP:0001082)2.08553326
85Abnormality of pyrimidine metabolism (HP:0004353)2.07075845
86Nephroblastoma (Wilms tumor) (HP:0002667)2.06535819
87Abnormality of the umbilical cord (HP:0010881)2.05827837
88Vertebral clefting (HP:0008428)2.05812381
89Trismus (HP:0000211)2.05739157
90Angiofibromas (HP:0010615)2.04761798
91Adenoma sebaceum (HP:0009720)2.04761798
92Abnormality of the renal collecting system (HP:0004742)2.04407990
93Supernumerary bones of the axial skeleton (HP:0009144)2.04250376
94Short thumb (HP:0009778)2.04051178
95Abnormal number of erythroid precursors (HP:0012131)2.04001592
96Progressive external ophthalmoplegia (HP:0000590)2.02609829
97Spinal muscular atrophy (HP:0007269)2.02099732
98High anterior hairline (HP:0009890)2.01139549
99Choanal atresia (HP:0000453)2.00272333
100Facial cleft (HP:0002006)2.00002434
101Abnormality of the fetal cardiovascular system (HP:0010948)1.98310948
102Abnormal umbilical cord blood vessels (HP:0011403)1.98310948
103Single umbilical artery (HP:0001195)1.98310948
104Gastrointestinal atresia (HP:0002589)1.97440546
105Breast aplasia (HP:0100783)1.96442189
106Abnormality of the carotid arteries (HP:0005344)1.96178759
107Prominent nose (HP:0000448)1.95733762
108Premature graying of hair (HP:0002216)1.95713281
109Overriding aorta (HP:0002623)1.95500438
110Supernumerary ribs (HP:0005815)1.94228769
111Ragged-red muscle fibers (HP:0003200)1.94204844
112Increased nuchal translucency (HP:0010880)1.93582674
113Ureteral duplication (HP:0000073)1.92968072
114Asymmetry of the thorax (HP:0001555)1.92200845
115Triphalangeal thumb (HP:0001199)1.91757621
116Ulnar bowing (HP:0003031)1.91488978
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.91475867
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.91359977
119Long palpebral fissure (HP:0000637)1.91014589
120Poikiloderma (HP:0001029)1.90933561
121Squamous cell carcinoma (HP:0002860)1.90128866
122Malignant gastrointestinal tract tumors (HP:0006749)1.89901964
123Gastrointestinal carcinoma (HP:0002672)1.89901964
124Pallor (HP:0000980)1.89302475
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88434789
126Intestinal fistula (HP:0100819)1.87485764
127Delayed puberty (HP:0000823)1.87394879
128Ovarian neoplasm (HP:0100615)1.86722639
129Embryonal renal neoplasm (HP:0011794)1.85438981
130Abnormality of glycolysis (HP:0004366)1.84826442
131Macrocytic anemia (HP:0001972)1.84298304
132Multiple enchondromatosis (HP:0005701)1.84135434
133Abnormality of chromosome segregation (HP:0002916)1.83668261
134Anal stenosis (HP:0002025)1.82706074
135Deep palmar crease (HP:0006191)1.81079363
136Truncus arteriosus (HP:0001660)1.79363848
137High pitched voice (HP:0001620)1.79145475
138Abnormality of DNA repair (HP:0003254)1.78407015
139Cortical dysplasia (HP:0002539)1.75671102
140Embryonal neoplasm (HP:0002898)1.75141659
141Abnormal lung lobation (HP:0002101)1.73316255
142Hypergonadotropic hypogonadism (HP:0000815)1.73142401
143Arteriovenous malformation (HP:0100026)1.70578627
144Morphological abnormality of the inner ear (HP:0011390)1.69306150
145Reticulocytosis (HP:0001923)1.64752944
146Ankyloglossia (HP:0010296)1.64310526
147Urethral obstruction (HP:0000796)1.64134964
148Cleft eyelid (HP:0000625)1.63132045
149Deep philtrum (HP:0002002)1.63050027
150Unilateral renal agenesis (HP:0000122)1.62924715
151Abnormal ventriculo-arterial connection (HP:0011563)1.62575372
152Transposition of the great arteries (HP:0001669)1.62575372
153Abnormal connection of the cardiac segments (HP:0011545)1.62575372
154Sparse lateral eyebrow (HP:0005338)1.60937120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.26643077
2SMG14.18260697
3CDC74.12450942
4BUB13.88574858
5CDK123.71602764
6EPHA23.61039733
7TRIB33.24935412
8NEK13.01968548
9TTK2.99224809
10NEK22.90104833
11VRK22.85515551
12TSSK62.40560103
13RPS6KB22.38128059
14IRAK32.32064903
15PBK2.26411128
16PLK12.10462236
17CDK72.07397168
18EEF2K1.94999459
19SRPK11.93995947
20PASK1.91983299
21EIF2AK11.82354275
22CHEK21.79669279
23TLK11.79365181
24ATR1.69763345
25AKT31.67485240
26CDK41.67244120
27TAF11.61410377
28PNCK1.60793828
29TESK21.59959369
30BRD41.55263200
31AURKB1.54563208
32MAP3K81.46481040
33CHEK11.44111859
34ACVR1B1.43201774
35PRPF4B1.41475727
36AURKA1.40210561
37PLK31.38482282
38BRSK21.35464176
39DYRK31.33557559
40SCYL21.31978250
41MAP3K101.23196070
42ALK1.22222676
43EIF2AK31.19593578
44STK101.19265458
45PLK41.17623522
46VRK11.15206996
47STK41.12907913
48MAPKAPK31.10130503
49NME21.09676894
50LATS21.09041673
51PAK41.07601735
52ATM1.05979808
53FLT31.05791443
54* CDK21.05723206
55SIK11.03336570
56MKNK11.01090623
57PIM11.00046148
58PKN20.97158202
59ICK0.95911792
60MKNK20.95695244
61PRKCI0.94080897
62ZAK0.90953630
63MTOR0.88079127
64STK38L0.82708900
65BRSK10.80572444
66MET0.73900650
67CDK60.73643591
68MST1R0.72614357
69MAP3K90.72473389
70IRAK20.72337307
71CSNK2A20.71441788
72* CDK10.70608317
73PAK10.69014310
74NME10.68699141
75ARAF0.66424974
76TGFBR10.65673251
77CLK10.65592047
78MELK0.65551129
79CSNK1D0.64734245
80CSNK1E0.64282173
81BRAF0.62055512
82RPS6KA40.61244695
83KSR20.61151611
84AKT20.59044489
85LATS10.56127159
86ILK0.55193475
87LMTK20.53612623
88STK30.52919981
89FGFR40.52810401
90* CSNK2A10.50017799
91KDR0.47396634
92PRKDC0.46597569
93PRKD30.45880600
94CDK150.45779018
95GRK60.44392826
96PDK40.43865356
97PDK30.43865356
98DAPK10.43722880
99RPS6KA50.43028398
100ERBB40.42222661
101CDK180.42197509
102EIF2AK20.41092666
103DYRK20.38725107
104TTN0.38337207
105PDK20.37201048
106* MAPK140.37037283
107ERN10.36859969
108BMX0.35926150
109CAMK1D0.35592884
110STK160.35172175
111CDK140.34848051
112TYRO30.32349959
113AKT10.31559906
114* GSK3B0.30932807
115IRAK40.29504376
116* MAPK10.29475731
117BCKDK0.28680085
118CAMK1G0.26900293
119PAK20.25696951
120LRRK20.25071250
121CDK80.24717041
122RPS6KA10.24596530
123MAPK110.22942990
124MAPK100.20792431
125MAP2K20.19610402
126TAOK20.19053615
127CCNB10.18855370
128MAP3K60.18382356
129CDK11A0.18189015
130CDK90.17023574

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.00983088
2Mismatch repair_Homo sapiens_hsa034304.75747321
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.90516594
4RNA transport_Homo sapiens_hsa030133.42980400
5One carbon pool by folate_Homo sapiens_hsa006703.33357995
6Spliceosome_Homo sapiens_hsa030403.24481606
7Homologous recombination_Homo sapiens_hsa034403.08168728
8Base excision repair_Homo sapiens_hsa034103.00406946
9Nucleotide excision repair_Homo sapiens_hsa034202.96903969
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.96411267
11Cell cycle_Homo sapiens_hsa041102.85538272
12RNA polymerase_Homo sapiens_hsa030202.73434148
13Ribosome_Homo sapiens_hsa030102.65923114
14Fanconi anemia pathway_Homo sapiens_hsa034602.48515077
15mRNA surveillance pathway_Homo sapiens_hsa030152.07142570
16Proteasome_Homo sapiens_hsa030502.06939035
17Non-homologous end-joining_Homo sapiens_hsa034502.06535119
18Pyrimidine metabolism_Homo sapiens_hsa002402.05813628
19RNA degradation_Homo sapiens_hsa030181.84890950
20Basal transcription factors_Homo sapiens_hsa030221.80995814
21p53 signaling pathway_Homo sapiens_hsa041151.72379221
22Systemic lupus erythematosus_Homo sapiens_hsa053221.38928716
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30257536
24Biosynthesis of amino acids_Homo sapiens_hsa012301.25023546
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.16907237
26Viral carcinogenesis_Homo sapiens_hsa052031.06832107
27Oocyte meiosis_Homo sapiens_hsa041141.06385268
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05380602
29Purine metabolism_Homo sapiens_hsa002301.01574421
30Epstein-Barr virus infection_Homo sapiens_hsa051691.01307806
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96659586
32Selenocompound metabolism_Homo sapiens_hsa004500.94775554
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92940419
34N-Glycan biosynthesis_Homo sapiens_hsa005100.92210618
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.91612873
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90173185
37Folate biosynthesis_Homo sapiens_hsa007900.89311755
38Pancreatic cancer_Homo sapiens_hsa052120.86103926
39Pentose phosphate pathway_Homo sapiens_hsa000300.83797595
40Hippo signaling pathway_Homo sapiens_hsa043900.83174890
41MicroRNAs in cancer_Homo sapiens_hsa052060.82916249
42Vitamin B6 metabolism_Homo sapiens_hsa007500.81421645
43Basal cell carcinoma_Homo sapiens_hsa052170.74332996
44Herpes simplex infection_Homo sapiens_hsa051680.72852954
45Pyruvate metabolism_Homo sapiens_hsa006200.68983873
46Fructose and mannose metabolism_Homo sapiens_hsa000510.68837383
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68022294
48Notch signaling pathway_Homo sapiens_hsa043300.67940039
49Antigen processing and presentation_Homo sapiens_hsa046120.67417530
50Thyroid cancer_Homo sapiens_hsa052160.65637999
51Carbon metabolism_Homo sapiens_hsa012000.63697083
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.63578377
53* HTLV-I infection_Homo sapiens_hsa051660.62487614
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62185154
55Glioma_Homo sapiens_hsa052140.61415425
56TGF-beta signaling pathway_Homo sapiens_hsa043500.61133087
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60340567
58Bladder cancer_Homo sapiens_hsa052190.57339802
59Small cell lung cancer_Homo sapiens_hsa052220.56632021
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55441507
61Alcoholism_Homo sapiens_hsa050340.54757712
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54754909
63Sulfur relay system_Homo sapiens_hsa041220.54604151
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53629838
65mTOR signaling pathway_Homo sapiens_hsa041500.53186080
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53029739
67Hedgehog signaling pathway_Homo sapiens_hsa043400.49678934
68Glutathione metabolism_Homo sapiens_hsa004800.48759050
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.47874165
70Colorectal cancer_Homo sapiens_hsa052100.46686724
71Adherens junction_Homo sapiens_hsa045200.45193825
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44706112
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43716343
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43341826
75Lysine degradation_Homo sapiens_hsa003100.43312405
76Steroid biosynthesis_Homo sapiens_hsa001000.42564293
77Tight junction_Homo sapiens_hsa045300.40069446
78Insulin signaling pathway_Homo sapiens_hsa049100.39199023
79Fatty acid elongation_Homo sapiens_hsa000620.38812077
80Renal cell carcinoma_Homo sapiens_hsa052110.36645496
81Galactose metabolism_Homo sapiens_hsa000520.35577180
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34207778
83Pathways in cancer_Homo sapiens_hsa052000.33500635
84Apoptosis_Homo sapiens_hsa042100.33210386
85B cell receptor signaling pathway_Homo sapiens_hsa046620.30970736
86HIF-1 signaling pathway_Homo sapiens_hsa040660.28707156
87ErbB signaling pathway_Homo sapiens_hsa040120.28268758
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28024885
89Arginine and proline metabolism_Homo sapiens_hsa003300.27163230
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25619934
91Melanoma_Homo sapiens_hsa052180.23146853
92Legionellosis_Homo sapiens_hsa051340.23019284
93Chronic myeloid leukemia_Homo sapiens_hsa052200.22594346
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22591826
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22057492
96Wnt signaling pathway_Homo sapiens_hsa043100.22041920
97Prostate cancer_Homo sapiens_hsa052150.22029768
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16056408
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14780145
100Renin-angiotensin system_Homo sapiens_hsa046140.14604463
101Acute myeloid leukemia_Homo sapiens_hsa052210.12918499
102Non-small cell lung cancer_Homo sapiens_hsa052230.11541817
103Hepatitis B_Homo sapiens_hsa051610.11151602
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11130725
105Huntingtons disease_Homo sapiens_hsa050160.10395628
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09965960
107Endometrial cancer_Homo sapiens_hsa052130.08104912
108Metabolic pathways_Homo sapiens_hsa011000.07402185
109Proteoglycans in cancer_Homo sapiens_hsa052050.05287919
110AMPK signaling pathway_Homo sapiens_hsa041520.04723311
111Shigellosis_Homo sapiens_hsa051310.04608014
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03688355
113FoxO signaling pathway_Homo sapiens_hsa040680.03590317
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01273939

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