MYBPHL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.71427818
2sarcomere organization (GO:0045214)8.80816804
3actin-myosin filament sliding (GO:0033275)8.65713334
4muscle filament sliding (GO:0030049)8.65713334
5myofibril assembly (GO:0030239)8.27662950
6cardiac muscle tissue morphogenesis (GO:0055008)7.68039147
7cardiac muscle hypertrophy (GO:0003300)7.67467991
8cardiac muscle contraction (GO:0060048)7.66713941
9heart contraction (GO:0060047)7.54118626
10heart process (GO:0003015)7.54118626
11actin-mediated cell contraction (GO:0070252)7.28988766
12striated muscle hypertrophy (GO:0014897)7.24282513
13potassium ion export (GO:0071435)7.09801654
14ventricular cardiac muscle tissue morphogenesis (GO:0055010)7.07587318
15cardiac muscle cell development (GO:0055013)7.02079886
16muscle tissue morphogenesis (GO:0060415)6.83115739
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.80067671
18cardiac cell development (GO:0055006)6.62358237
19regulation of sarcomere organization (GO:0060297)6.55364673
20muscle hypertrophy (GO:0014896)6.45647038
21regulation of relaxation of muscle (GO:1901077)6.40438156
22ATP synthesis coupled proton transport (GO:0015986)6.28396468
23energy coupled proton transport, down electrochemical gradient (GO:0015985)6.28396468
24adult heart development (GO:0007512)6.22273715
25negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.12542498
26actomyosin structure organization (GO:0031032)6.08035414
27tricarboxylic acid cycle (GO:0006099)5.94536815
28heart trabecula formation (GO:0060347)5.78013711
29detection of calcium ion (GO:0005513)5.77925583
30cardiac muscle hypertrophy in response to stress (GO:0014898)5.73448870
31muscle hypertrophy in response to stress (GO:0003299)5.73448870
32cardiac muscle adaptation (GO:0014887)5.73448870
33negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.69495686
34striated muscle contraction (GO:0006941)5.67313726
35regulation of cardioblast differentiation (GO:0051890)5.65025373
36negative regulation of potassium ion transmembrane transport (GO:1901380)5.54623303
37oxidative phosphorylation (GO:0006119)5.54506067
38regulation of the force of heart contraction (GO:0002026)5.54424480
39cardiac ventricle formation (GO:0003211)5.44075195
40regulation of actin filament-based movement (GO:1903115)5.41532026
41regulation of cell communication by electrical coupling (GO:0010649)5.40982218
42actin filament-based movement (GO:0030048)5.39187842
43ventricular cardiac muscle cell development (GO:0055015)5.10406532
44negative regulation of striated muscle cell apoptotic process (GO:0010664)5.06335808
45regulation of cardiac muscle cell contraction (GO:0086004)4.97174008
46respiratory electron transport chain (GO:0022904)4.92953926
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.92003928
48bundle of His cell to Purkinje myocyte communication (GO:0086069)4.82455805
49electron transport chain (GO:0022900)4.80882084
50regulation of striated muscle contraction (GO:0006942)4.80646007
51regulation of skeletal muscle contraction (GO:0014819)4.77969906
52regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.74669165
53ventricular cardiac muscle cell action potential (GO:0086005)4.68029622
54negative regulation of cardiac muscle tissue growth (GO:0055022)4.55179936
55negative regulation of heart growth (GO:0061117)4.55179936
56regulation of ATPase activity (GO:0043462)4.53986535
57regulation of ATP catabolic process (GO:1903289)4.53986535
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.49306184
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.45806559
60regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.20957520
61atrioventricular valve morphogenesis (GO:0003181)4.17413925
62regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.17128061
63sarcoplasmic reticulum calcium ion transport (GO:0070296)4.17075761
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.14243730
65NADH metabolic process (GO:0006734)4.13936429
66ATP biosynthetic process (GO:0006754)4.12677574
67regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.12256336
68endocardial cushion development (GO:0003197)4.04538180
69positive regulation of cardiac muscle cell proliferation (GO:0060045)4.01976307
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.93014014
71atrial septum morphogenesis (GO:0060413)3.91971661
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.91688327
73regulation of striated muscle cell apoptotic process (GO:0010662)3.88054173
74positive regulation of cardiac muscle tissue growth (GO:0055023)3.86943978
75regulation of lipoprotein metabolic process (GO:0050746)3.82611168
76trabecula formation (GO:0060343)3.81404130
77regulation of cardioblast proliferation (GO:0003264)3.80422176
78regulation of secondary heart field cardioblast proliferation (GO:0003266)3.80422176
79regulation of acyl-CoA biosynthetic process (GO:0050812)3.80253285
80striated muscle adaptation (GO:0014888)3.78532889
81negative regulation of cytosolic calcium ion concentration (GO:0051481)3.76631038
82striated muscle cell development (GO:0055002)3.74185955
83carnitine shuttle (GO:0006853)3.72814839
84positive regulation of cardiac muscle tissue development (GO:0055025)3.72019384
85cardiac right ventricle morphogenesis (GO:0003215)3.70684077
86negative regulation of protein localization to cell surface (GO:2000009)3.68319430
87cardiac chamber formation (GO:0003207)3.67521902
88outflow tract septum morphogenesis (GO:0003148)3.66426711
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.65223603
90regulation of cofactor metabolic process (GO:0051193)3.64685210
91regulation of coenzyme metabolic process (GO:0051196)3.64685210
92cell communication involved in cardiac conduction (GO:0086065)3.57518319
93regulation of voltage-gated calcium channel activity (GO:1901385)3.57098147
94cytidine metabolic process (GO:0046087)3.55148451
95cytidine catabolic process (GO:0006216)3.55148451
96cytidine deamination (GO:0009972)3.55148451
97atrial cardiac muscle cell action potential (GO:0086014)3.53204268
98regulation of cardiac muscle cell apoptotic process (GO:0010665)3.51263728
99negative regulation of cardiac muscle hypertrophy (GO:0010614)3.51126589
100regulation of heart rate (GO:0002027)3.50304751
101cell communication by electrical coupling (GO:0010644)3.49788707
102regulation of membrane repolarization (GO:0060306)3.49304333
103plasma membrane repair (GO:0001778)3.49167959
104regulation of cardiac muscle contraction (GO:0055117)3.48041247
105cardiac muscle tissue development (GO:0048738)3.47788982
106receptor guanylyl cyclase signaling pathway (GO:0007168)3.45321484
107negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.44829895
108negative regulation of calcium ion transmembrane transport (GO:1903170)3.44829895
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42770890
110positive regulation of ATP catabolic process (GO:1903291)3.42755561
111positive regulation of ATPase activity (GO:0032781)3.42755561
112cardiac muscle cell action potential involved in contraction (GO:0086002)3.42169974
113regulation of muscle contraction (GO:0006937)3.41343212
114regulation of heart contraction (GO:0008016)3.40927775
115response to inactivity (GO:0014854)3.39026774
116positive regulation of heart growth (GO:0060421)3.36294354
117cardiac muscle cell action potential (GO:0086001)3.34822596
118cardiac conduction (GO:0061337)3.33829289
119cell migration involved in heart development (GO:0060973)3.26816538
120negative regulation of heart rate (GO:0010459)3.26377840
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.25908836
122positive regulation of sodium ion transport (GO:0010765)3.25804312
123purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25580151
124neuronal ion channel clustering (GO:0045161)3.24518491
125regulation of cardiac muscle tissue growth (GO:0055021)3.23828609
126purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23825939
127pyrimidine ribonucleoside catabolic process (GO:0046133)3.22750496
128negative regulation of potassium ion transport (GO:0043267)3.18392632
129positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.15622519
130positive regulation of action potential (GO:0045760)3.11004162
131regulation of heart rate by cardiac conduction (GO:0086091)3.11000260
132positive regulation of heart contraction (GO:0045823)3.09537782
133membrane repolarization (GO:0086009)3.06182397
134regulation of calcium ion transmembrane transporter activity (GO:1901019)3.05581323
135regulation of calcium ion transmembrane transport (GO:1903169)3.05581323
136regulation of cation channel activity (GO:2001257)3.05083640
137protein maturation by protein folding (GO:0022417)2.89832290
138negative regulation of cardiac muscle tissue development (GO:0055026)2.87782190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.79806605
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.71285282
3* EP300_21415370_ChIP-Seq_HL-1_Mouse6.28000057
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.68454235
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.04212173
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.88949657
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.67211097
8EZH2_22144423_ChIP-Seq_EOC_Human4.28845233
9TRIM28_21343339_ChIP-Seq_HEK293_Human4.15115662
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.98142964
11* TBX20_22080862_ChIP-Seq_HEART_Mouse3.88832966
12* TBX20_22328084_ChIP-Seq_HEART_Mouse3.88832966
13GATA4_21415370_ChIP-Seq_HL-1_Mouse3.45930635
14ESR1_20079471_ChIP-ChIP_T-47D_Human3.41309258
15IKZF1_21737484_ChIP-ChIP_HCT116_Human3.29969928
16GATA1_22025678_ChIP-Seq_K562_Human3.29163724
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.10933282
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.92515800
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91530771
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.69140791
21* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.57819047
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.49223185
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43141087
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42852320
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.38978825
26VDR_22108803_ChIP-Seq_LS180_Human2.33581402
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23596066
28ISL1_27105846_Chip-Seq_CPCs_Mouse2.21849854
29CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12872373
30WT1_19549856_ChIP-ChIP_CCG9911_Human2.11537136
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10434347
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85870045
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85494401
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.77440709
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76557975
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75820756
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73227789
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.73010677
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68580482
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67823301
41REST_21632747_ChIP-Seq_MESCs_Mouse1.67603887
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61810544
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60006106
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.59353373
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.55613917
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.51840174
47CLOCK_20551151_ChIP-Seq_293T_Human1.45674883
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43640618
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38411642
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37297157
51ZNF274_21170338_ChIP-Seq_K562_Hela1.35799677
52TBX5_21415370_ChIP-Seq_HL-1_Mouse1.31919392
53CTCF_27219007_Chip-Seq_Bcells_Human1.31647877
54GBX2_23144817_ChIP-Seq_PC3_Human1.31391863
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30066381
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.30028692
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29721388
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29568076
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29405446
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27213688
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26730416
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26137928
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.23649706
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20498351
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20117263
66SMAD4_21799915_ChIP-Seq_A2780_Human1.18159001
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18114600
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.12171144
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11744965
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09781099
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02119823
72IGF1R_20145208_ChIP-Seq_DFB_Human1.01790589
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01123142
74RNF2_27304074_Chip-Seq_NSC_Mouse1.00381578
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00027712
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00027712
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99450643
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99387794
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98693427
80BCAT_22108803_ChIP-Seq_LS180_Human0.97283858
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96675546
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96670549
83CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96565011
84* RBPJ_21746931_ChIP-Seq_IB4_Human0.96414885
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95998576
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95939912
87SPI1_20517297_ChIP-Seq_HL60_Human0.95642482
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95326576
89* GATA3_21878914_ChIP-Seq_MCF-7_Human0.94808210
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94324917
91* PHF8_20622853_ChIP-Seq_HELA_Human0.94105983
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93703612
93STAT1_20625510_ChIP-Seq_HELA_Human0.93528618
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92412937
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91687393
96* MYC_19829295_ChIP-Seq_ESCs_Human0.90929592
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88097463
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87610913
99* RARB_27405468_Chip-Seq_BRAIN_Mouse0.86764213
100* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86685979
101JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85792459
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85366970
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84723166
104* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84648025
105YY1_21170310_ChIP-Seq_MESCs_Mouse0.84289208
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83448172
107THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82038898
108* HNFA_21074721_ChIP-Seq_CACO-2_Human0.81721088
109* NFYA_21822215_ChIP-Seq_K562_Human0.81538951
110* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80276327
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79693178
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79619991
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78870742
114FOXH1_21741376_ChIP-Seq_ESCs_Human0.78754119
115* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78669056
116* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78469225
117NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78254016
118CBP_21632823_ChIP-Seq_H3396_Human0.76808084
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.76420133
120* TBL1_22424771_ChIP-Seq_293T_Human0.75912976
121SMC4_20622854_ChIP-Seq_HELA_Human0.75868718
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75628788
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75610907
124NCOR_22424771_ChIP-Seq_293T_Human0.75243166
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.75001921
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74986862
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74567674
128RING1B_27294783_Chip-Seq_ESCs_Mouse0.73443359
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.73340549
130OCT4_19829295_ChIP-Seq_ESCs_Human0.73070709
131GATA1_19941826_ChIP-Seq_K562_Human0.72377126
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71999611
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70508369
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70412360
135E2F1_18555785_ChIP-Seq_MESCs_Mouse0.68910733
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.68899428
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.68447107
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68247928
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.67827442
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67567725
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67237361
142HTT_18923047_ChIP-ChIP_STHdh_Human0.66474518
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66374242
144EGR1_19032775_ChIP-ChIP_M12_Human0.63613549
145NFI_21473784_ChIP-Seq_ESCs_Mouse0.63421292
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.62171124
147EOMES_21245162_ChIP-Seq_HESCs_Human0.61910485
148GF1_26923725_Chip-Seq_HPCs_Mouse0.60762788
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.59130377
150ZNF263_19887448_ChIP-Seq_K562_Human0.58804449
151EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.57685557
152NANOG_18555785_ChIP-Seq_MESCs_Mouse0.57655410
153JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.57119646
154CJUN_26792858_Chip-Seq_BT549_Human0.56323282
155* OCT4_20526341_ChIP-Seq_ESCs_Human0.55618476
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.55554194
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.55463127
158* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.55246138
159TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.54927217
160* LXR_22158963_ChIP-Seq_LIVER_Mouse0.54826096
161* TP63_22573176_ChIP-Seq_HFKS_Human0.54747725
162PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53924662
163LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.53410831
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.52667783
165ERA_21632823_ChIP-Seq_H3396_Human0.52303727
166MYC_19030024_ChIP-ChIP_MESCs_Mouse0.52216056
167SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.50743968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.69651534
2MP0002837_dystrophic_cardiac_calcinosis5.20255311
3MP0000749_muscle_degeneration4.68015162
4MP0004036_abnormal_muscle_relaxation4.65780522
5MP0004215_abnormal_myocardial_fiber4.33682224
6MP0005330_cardiomyopathy4.12581439
7MP0000751_myopathy3.93688232
8MP0002972_abnormal_cardiac_muscle3.75698677
9MP0008775_abnormal_heart_ventricle3.74822850
10MP0003646_muscle_fatigue3.65490701
11MP0003828_pulmonary_edema3.00085536
12MP0004087_abnormal_muscle_fiber2.99126813
13MP0003137_abnormal_impulse_conducting2.97056585
14MP0010630_abnormal_cardiac_muscle2.95975880
15MP0006138_congestive_heart_failure2.90300815
16MP0001544_abnormal_cardiovascular_syste2.89941020
17MP0005385_cardiovascular_system_phenoty2.89941020
18MP0005620_abnormal_muscle_contractility2.78432760
19MP0003221_abnormal_cardiomyocyte_apopto2.72613791
20MP0004085_abnormal_heartbeat2.63178456
21MP0004510_myositis2.47655888
22MP0002127_abnormal_cardiovascular_syste2.37086948
23MP0002106_abnormal_muscle_physiology2.23203891
24MP0004484_altered_response_of2.19678961
25MP0005451_abnormal_body_composition2.12407716
26MP0002269_muscular_atrophy2.11748812
27MP0004145_abnormal_muscle_electrophysio2.08476546
28MP0003950_abnormal_plasma_membrane2.07292175
29MP0006036_abnormal_mitochondrial_physio2.04758545
30MP0008004_abnormal_stomach_pH2.01752284
31MP0002822_catalepsy1.96545078
32MP0003567_abnormal_fetal_cardiomyocyte1.95941781
33MP0000750_abnormal_muscle_regeneration1.93608476
34MP0009780_abnormal_chondrocyte_physiolo1.86912892
35MP0005369_muscle_phenotype1.78746951
36MP0003787_abnormal_imprinting1.74034708
37MP0002653_abnormal_ependyma_morphology1.64081317
38MP0003122_maternal_imprinting1.55370155
39MP0000747_muscle_weakness1.54397156
40MP0008877_abnormal_DNA_methylation1.54161941
41MP0000759_abnormal_skeletal_muscle1.51885993
42MP0003011_delayed_dark_adaptation1.44405579
43MP0002332_abnormal_exercise_endurance1.43756066
44MP0002909_abnormal_adrenal_gland1.39723604
45MP0003806_abnormal_nucleotide_metabolis1.37571301
46MP0000266_abnormal_heart_morphology1.34980530
47MP0004233_abnormal_muscle_weight1.33940306
48MP0004130_abnormal_muscle_cell1.33095059
49MP0001529_abnormal_vocalization1.28985018
50MP0004270_analgesia1.20765757
51MP0003566_abnormal_cell_adhesion1.18447753
52MP0006035_abnormal_mitochondrial_morpho1.17801222
53MP0004272_abnormal_basement_membrane1.17678380
54MP0005551_abnormal_eye_electrophysiolog1.11731557
55MP0005083_abnormal_biliary_tract1.10923318
56MP0003941_abnormal_skin_development1.08798598
57MP0003880_abnormal_central_pattern1.06805496
58MP0001968_abnormal_touch/_nociception1.06637370
59MP0009745_abnormal_behavioral_response1.06305857
60MP0003279_aneurysm1.06056441
61MP0000343_altered_response_to1.05826080
62MP0005167_abnormal_blood-brain_barrier1.02797369
63MP0002736_abnormal_nociception_after0.98945201
64MP0002234_abnormal_pharynx_morphology0.98635615
65MP0000230_abnormal_systemic_arterial0.95359981
66MP0002078_abnormal_glucose_homeostasis0.94792616
67MP0002735_abnormal_chemical_nociception0.88971599
68MP0009384_cardiac_valve_regurgitation0.84350032
69MP0005266_abnormal_metabolism0.84025817
70MP0000013_abnormal_adipose_tissue0.83558324
71MP0002088_abnormal_embryonic_growth/wei0.83424670
72MP0002128_abnormal_blood_circulation0.83294610
73MP0003879_abnormal_hair_cell0.82837781
74MP0003984_embryonic_growth_retardation0.82376528
75MP0001986_abnormal_taste_sensitivity0.80791084
76MP0002090_abnormal_vision0.79314043
77MP0005423_abnormal_somatic_nervous0.78207113
78MP0004924_abnormal_behavior0.77447142
79MP0005386_behavior/neurological_phenoty0.77447142
80MP0005448_abnormal_energy_balance0.77392781
81MP0002272_abnormal_nervous_system0.76472627
82MP0002925_abnormal_cardiovascular_devel0.75865339
83MP0008874_decreased_physiological_sensi0.74682939
84MP0002064_seizures0.73353815
85MP0001984_abnormal_olfaction0.73317580
86MP0003123_paternal_imprinting0.73188283
87MP0005165_increased_susceptibility_to0.72658938
88MP0000767_abnormal_smooth_muscle0.72533695
89MP0005253_abnormal_eye_physiology0.71957435
90MP0010368_abnormal_lymphatic_system0.69888568
91MP0002971_abnormal_brown_adipose0.68260901
92MP0009697_abnormal_copulation0.67085503
93MP0004133_heterotaxia0.66421464
94MP0003121_genomic_imprinting0.64215279
95MP0002063_abnormal_learning/memory/cond0.64070926
96MP0002163_abnormal_gland_morphology0.63865595
97MP0001970_abnormal_pain_threshold0.62275915
98MP0001905_abnormal_dopamine_level0.61640255
99MP0005377_hearing/vestibular/ear_phenot0.60688202
100MP0003878_abnormal_ear_physiology0.60688202
101MP0005379_endocrine/exocrine_gland_phen0.60415689
102MP0003953_abnormal_hormone_level0.60077929
103MP0006072_abnormal_retinal_apoptosis0.60049916
104MP0002693_abnormal_pancreas_physiology0.59972839
105MP0002572_abnormal_emotion/affect_behav0.58999471
106MP0002133_abnormal_respiratory_system0.58593538
107MP0005388_respiratory_system_phenotype0.58593538
108MP0008875_abnormal_xenobiotic_pharmacok0.58042720
109MP0001672_abnormal_embryogenesis/_devel0.56343259
110MP0005380_embryogenesis_phenotype0.56343259
111MP0001944_abnormal_pancreas_morphology0.56211405
112MP0000003_abnormal_adipose_tissue0.55493196
113MP0001784_abnormal_fluid_regulation0.55171907
114MP0005535_abnormal_body_temperature0.55046551
115MP0004147_increased_porphyrin_level0.53663082
116MP0003635_abnormal_synaptic_transmissio0.53112071
117MP0005666_abnormal_adipose_tissue0.52296831
118MP0001614_abnormal_blood_vessel0.51612062
119MP0002733_abnormal_thermal_nociception0.51142914
120MP0001730_embryonic_growth_arrest0.48523539
121MP0005670_abnormal_white_adipose0.47210735
122MP0001879_abnormal_lymphatic_vessel0.45703135
123MP0004043_abnormal_pH_regulation0.44490265
124MP0005595_abnormal_vascular_smooth0.44421606
125MP0003115_abnormal_respiratory_system0.42624797
126MP0005503_abnormal_tendon_morphology0.40679441
127MP0001175_abnormal_lung_morphology0.39799146
128MP0005171_absent_coat_pigmentation0.39749741
129MP0002108_abnormal_muscle_morphology0.39270466
130MP0000762_abnormal_tongue_morphology0.36364061
131MP0001697_abnormal_embryo_size0.36250948
132MP0002132_abnormal_respiratory_system0.36071659
133MP0002933_joint_inflammation0.35957844
134MP0008438_abnormal_cutaneous_collagen0.34970420
135MP0005584_abnormal_enzyme/coenzyme_acti0.34504039
136MP0003186_abnormal_redox_activity0.34257519
137MP0003948_abnormal_gas_homeostasis0.33742277
138MP0003119_abnormal_digestive_system0.31840523
139MP0002086_abnormal_extraembryonic_tissu0.31211944
140MP0005319_abnormal_enzyme/_coenzyme0.30708646
141MP0005623_abnormal_meninges_morphology0.27128494
142MP0003385_abnormal_body_wall0.26814343
143MP0002282_abnormal_trachea_morphology0.26067054
144MP0000537_abnormal_urethra_morphology0.24703728
145MP0005332_abnormal_amino_acid0.24466908
146MP0005375_adipose_tissue_phenotype0.24221591
147MP0005376_homeostasis/metabolism_phenot0.23818355
148MP0003935_abnormal_craniofacial_develop0.23033736
149MP0002295_abnormal_pulmonary_circulatio0.22876725

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.18336032
2Exercise-induced muscle cramps (HP:0003710)6.93160306
3Ventricular tachycardia (HP:0004756)6.56665753
4Atrial fibrillation (HP:0005110)6.52639705
5Calf muscle hypertrophy (HP:0008981)6.45421985
6Primary atrial arrhythmia (HP:0001692)6.07909456
7Supraventricular tachycardia (HP:0004755)5.89748560
8Supraventricular arrhythmia (HP:0005115)5.75025506
9Muscle hypertrophy of the lower extremities (HP:0008968)5.74173212
10Lipoatrophy (HP:0100578)5.69274555
11Exercise-induced myalgia (HP:0003738)5.65594330
12Subaortic stenosis (HP:0001682)4.92540493
13Abnormality of the left ventricular outflow tract (HP:0011103)4.92540493
14Myoglobinuria (HP:0002913)4.86268381
15Abnormality of the calf musculature (HP:0001430)4.80489167
16Dilated cardiomyopathy (HP:0001644)4.51210274
17Right ventricular cardiomyopathy (HP:0011663)4.41723782
18Syncope (HP:0001279)4.36498180
19Palpitations (HP:0001962)4.27468058
20Prolonged QT interval (HP:0001657)4.24598820
21Hyporeflexia of lower limbs (HP:0002600)4.07138949
22Acute necrotizing encephalopathy (HP:0006965)4.06099285
23Ventricular arrhythmia (HP:0004308)4.05011849
24Abnormal mitochondria in muscle tissue (HP:0008316)3.93490247
25Rhabdomyolysis (HP:0003201)3.93287705
26Mesangial abnormality (HP:0001966)3.68928262
27EMG: myopathic abnormalities (HP:0003458)3.55886051
28Asymmetric septal hypertrophy (HP:0001670)3.54389726
29Muscle fiber splitting (HP:0003555)3.44516441
30Anomalous pulmonary venous return (HP:0010772)3.44015440
31Hepatic necrosis (HP:0002605)3.35921594
32Acute encephalopathy (HP:0006846)3.30895964
33Heart block (HP:0012722)3.30878001
34Progressive macrocephaly (HP:0004481)3.29672834
35Atrioventricular block (HP:0001678)3.29402761
36Hypoplastic left heart (HP:0004383)3.28563323
37Bundle branch block (HP:0011710)3.27939879
38Distal lower limb muscle weakness (HP:0009053)3.20714115
39Aplasia of the musculature (HP:0100854)3.17521992
40Mitochondrial inheritance (HP:0001427)3.16101981
41Left ventricular hypertrophy (HP:0001712)3.15682406
42Ventricular fibrillation (HP:0001663)3.14772936
43Abnormal EKG (HP:0003115)3.12208723
44Bradycardia (HP:0001662)3.11847652
45Exercise intolerance (HP:0003546)3.11815759
46Abnormal atrioventricular conduction (HP:0005150)3.06640346
47Increased CSF lactate (HP:0002490)3.03946744
48Pheochromocytoma (HP:0002666)3.02018649
49Ragged-red muscle fibers (HP:0003200)3.01302648
50Congenital malformation of the right heart (HP:0011723)2.91030327
51Double outlet right ventricle (HP:0001719)2.91030327
52Abnormality of the pulmonary veins (HP:0011718)2.91003675
53Palmoplantar keratoderma (HP:0000982)2.87488529
54Cerebral edema (HP:0002181)2.84446572
55Abnormality of glycolysis (HP:0004366)2.82665090
56Increased serum pyruvate (HP:0003542)2.82665090
57Conjunctival hamartoma (HP:0100780)2.82136448
58Hypoglycemic coma (HP:0001325)2.81180872
59Hepatocellular necrosis (HP:0001404)2.76261758
60Patent foramen ovale (HP:0001655)2.72822407
61Neuroendocrine neoplasm (HP:0100634)2.72679013
62Neoplasm of the adrenal gland (HP:0100631)2.71323651
63Truncus arteriosus (HP:0001660)2.59871076
64Hypoplastic heart (HP:0001961)2.50338635
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48673391
66Dicarboxylic aciduria (HP:0003215)2.48673391
67Lactic acidosis (HP:0003128)2.41667135
68Ketoacidosis (HP:0001993)2.39714156
69Decreased circulating renin level (HP:0003351)2.39628018
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.33228166
71Respiratory failure (HP:0002878)2.32659919
72Myotonia (HP:0002486)2.29529852
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28342005
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28342005
75Myokymia (HP:0002411)2.27977246
76Abnormality of the foot musculature (HP:0001436)2.24670391
77Generalized aminoaciduria (HP:0002909)2.23989755
78Lipid accumulation in hepatocytes (HP:0006561)2.22406911
79Increased connective tissue (HP:0009025)2.20856654
80Diaphragmatic weakness (HP:0009113)2.20321273
81Increased muscle lipid content (HP:0009058)2.18494846
82Partial duplication of thumb phalanx (HP:0009944)2.16346885
83Glycosuria (HP:0003076)2.14713928
84Abnormality of urine glucose concentration (HP:0011016)2.14713928
85Congestive heart failure (HP:0001635)2.13432139
86Proximal tubulopathy (HP:0000114)2.13067365
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12726787
88Abnormality of fatty-acid metabolism (HP:0004359)2.12103979
89Nausea (HP:0002018)2.11287824
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10642750
91Neck muscle weakness (HP:0000467)2.09701500
92Increased intramyocellular lipid droplets (HP:0012240)2.09538899
93Increased hepatocellular lipid droplets (HP:0006565)2.08527059
94Increased variability in muscle fiber diameter (HP:0003557)2.08033581
95Generalized muscle weakness (HP:0003324)2.04893186
96Rimmed vacuoles (HP:0003805)2.03557578
97Abnormality of the vocal cords (HP:0008777)2.03523842
98Testicular atrophy (HP:0000029)2.03092073
99Neoplasm of the peripheral nervous system (HP:0100007)2.02746619
100Areflexia of lower limbs (HP:0002522)2.02733244
101Increased serum lactate (HP:0002151)2.01184435
102Ependymoma (HP:0002888)1.99294003
103Pulmonary artery stenosis (HP:0004415)1.98978989
104Renal cortical cysts (HP:0000803)1.96878647
105Periauricular skin pits (HP:0100277)1.95476662
106Preauricular pit (HP:0004467)1.95476662
107Foot dorsiflexor weakness (HP:0009027)1.94308528
108Abnormality of skeletal muscle fiber size (HP:0012084)1.93657896
109Limb hypertonia (HP:0002509)1.93650757
110Distal lower limb amyotrophy (HP:0008944)1.93565092
111Muscle stiffness (HP:0003552)1.91742047
112Intestinal atresia (HP:0011100)1.89812447
113Ketosis (HP:0001946)1.89329869
114Resting tremor (HP:0002322)1.88516901
115Tinnitus (HP:0000360)1.87640270
116Hemiparesis (HP:0001269)1.86551361
117EMG: neuropathic changes (HP:0003445)1.85527433
118Hyperthyroidism (HP:0000836)1.85264186
119Abnormal ventriculo-arterial connection (HP:0011563)1.85263392
120Transposition of the great arteries (HP:0001669)1.85263392
121Abnormal connection of the cardiac segments (HP:0011545)1.85263392
122Pancreatic islet-cell hyperplasia (HP:0004510)1.84052408
123Abnormality of the tricuspid valve (HP:0001702)1.83685721
124Optic disc pallor (HP:0000543)1.80736752
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76019833
126Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73880233
127Partial duplication of the phalanx of hand (HP:0009999)1.69389133
128Bulbar palsy (HP:0001283)1.68026968
129Poor suck (HP:0002033)1.66670137
130X-linked dominant inheritance (HP:0001423)1.65403843
1313-Methylglutaconic aciduria (HP:0003535)1.61755401
132Atrioventricular canal defect (HP:0006695)1.60828734
133Sudden cardiac death (HP:0001645)1.57542799
134Complete atrioventricular canal defect (HP:0001674)1.56662290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.99868646
2MYLK6.07470673
3STK244.52820419
4TTN3.93790130
5LMTK23.50392410
6MAPKAPK33.41724412
7PKN23.25582408
8PIK3CA3.15600176
9ZAK2.98200188
10STK38L2.49732579
11PDK42.37676353
12PDK32.37676353
13WNK32.37254276
14MUSK2.32308817
15IRAK22.29756352
16PHKG12.20776060
17PHKG22.20776060
18BCKDK2.20074548
19NEK11.87154146
20DMPK1.85274282
21CDC42BPA1.82869010
22MAP2K71.78691736
23MST41.73405490
24TIE11.63002708
25FLT31.58710127
26ILK1.56575466
27NTRK31.46359929
28PDK21.44422545
29STK161.44327499
30PIM21.39860628
31PAK31.38514742
32TRPM71.33502149
33LIMK11.31531445
34DAPK31.28105069
35ARAF1.25471236
36GRK11.22425604
37STK41.21130783
38MAP3K41.20144524
39PINK11.13066363
40TRIB31.12809078
41MAP3K31.11107476
42MAP2K31.09644934
43ROCK11.09176787
44PRKD31.06993597
45CCNB11.06289277
46PBK1.03853208
47MAP4K21.02579418
48ERBB41.01643045
49EPHA30.98843801
50CAMK2D0.97682106
51PRKD10.94203726
52MARK10.93510238
53PRKCG0.93076879
54GRK70.90784396
55ERBB20.81174037
56CAMK10.80658120
57CASK0.79283799
58PTK2B0.75796599
59NTRK20.73606116
60MARK30.71938173
61TESK10.65688717
62SGK10.63758204
63RIPK40.59321433
64MAP3K50.59142445
65SGK2230.58942394
66SGK4940.58942394
67DAPK20.58513035
68CAMK2A0.58234106
69AKT30.57736311
70WNK40.56652138
71EPHB10.55940181
72PKN10.55685817
73PRKCI0.55419443
74STK30.55352204
75ROCK20.55298026
76MAP3K60.53914635
77MAP2K40.53466319
78RPS6KC10.53008169
79RPS6KL10.53008169
80CAMK40.52139498
81FRK0.51132954
82PRKAA10.50546262
83MINK10.50223795
84MAPK130.50147428
85RPS6KA10.49258209
86KDR0.49142862
87PRKG20.48609083
88FGFR10.48295373
89NUAK10.48157458
90MAPK120.47517527
91PRKACB0.47460479
92PRKCE0.46954271
93DAPK10.45236174
94TLK10.44029928
95FGFR40.43975041
96PRKAA20.43025471
97ADRBK20.41855949
98RPS6KA60.40554812
99SGK30.40241023
100PRKCA0.40110930
101RPS6KA30.38817000
102TGFBR20.38697391
103CSNK1G30.38494177
104TGFBR10.38310668
105CSNK1G10.35977511
106BMX0.35487648
107CSNK1G20.34923595
108PRKACA0.34747829
109CSNK1E0.34627840
110MAP2K60.34587350
111PRKG10.32487352
112UHMK10.32144520
113PRKCH0.32109477
114INSRR0.29957105
115WNK10.26366911
116BRSK20.25900653
117NEK90.25781457
118PAK20.25596875
119CAMK2G0.24314505
120EPHB20.23534160
121PRKCQ0.22494691
122PRKACG0.22418268
123MET0.21191633
124STK390.19257597
125MAPKAPK20.18745727
126AKT20.18742429
127BCR0.16863200
128LATS20.16167411
129AURKB0.15733939
130MAP3K70.13887115
131DYRK20.13569691
132TYK20.13468975
133EGFR0.13412767
134NME20.12163993
135MAPK110.12077549
136MAP3K110.09728188
137STK380.09508785
138CAMK1D0.09367305
139BRSK10.09058610
140CDK40.06277913
141PLK20.06139032
142SGK20.05710133
143ADRBK10.04922203
144RIPK10.04807204
145FER0.04769850
146MAP2K10.04758745
147PDK10.04732665

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.68895382
2Cardiac muscle contraction_Homo sapiens_hsa042605.52659771
3Parkinsons disease_Homo sapiens_hsa050124.30125343
4Oxidative phosphorylation_Homo sapiens_hsa001904.16822553
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.67718897
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.64720382
7Dilated cardiomyopathy_Homo sapiens_hsa054143.56808819
8Alzheimers disease_Homo sapiens_hsa050103.01428996
9Huntingtons disease_Homo sapiens_hsa050162.92562137
10Carbon metabolism_Homo sapiens_hsa012002.63279719
11Propanoate metabolism_Homo sapiens_hsa006402.60747692
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.52351380
13Caffeine metabolism_Homo sapiens_hsa002322.48494043
14Fatty acid degradation_Homo sapiens_hsa000712.15745971
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.99811522
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89142819
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83711895
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81130845
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79647979
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76059390
21Pyruvate metabolism_Homo sapiens_hsa006201.70555586
22Fatty acid metabolism_Homo sapiens_hsa012121.70118560
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.69160450
24Biosynthesis of amino acids_Homo sapiens_hsa012301.65591150
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47489438
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47187413
27Fatty acid elongation_Homo sapiens_hsa000621.45812769
28Morphine addiction_Homo sapiens_hsa050321.45555926
29Collecting duct acid secretion_Homo sapiens_hsa049661.45417263
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42796287
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.40514403
32GABAergic synapse_Homo sapiens_hsa047271.34635349
33Synaptic vesicle cycle_Homo sapiens_hsa047211.02463136
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02135094
35HIF-1 signaling pathway_Homo sapiens_hsa040661.01603204
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00723639
37Galactose metabolism_Homo sapiens_hsa000521.00355157
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98759180
39Phenylalanine metabolism_Homo sapiens_hsa003600.98595813
40Fat digestion and absorption_Homo sapiens_hsa049750.94710677
41Viral myocarditis_Homo sapiens_hsa054160.93839179
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93523434
43Fructose and mannose metabolism_Homo sapiens_hsa000510.93303696
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91168340
45Glucagon signaling pathway_Homo sapiens_hsa049220.87372058
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.86024240
47Dopaminergic synapse_Homo sapiens_hsa047280.84408133
48Nitrogen metabolism_Homo sapiens_hsa009100.84032933
49Butanoate metabolism_Homo sapiens_hsa006500.82152195
50Tight junction_Homo sapiens_hsa045300.80615879
51Serotonergic synapse_Homo sapiens_hsa047260.77022587
52Starch and sucrose metabolism_Homo sapiens_hsa005000.75952447
53Ovarian steroidogenesis_Homo sapiens_hsa049130.75311061
54Linoleic acid metabolism_Homo sapiens_hsa005910.75219888
55Glutamatergic synapse_Homo sapiens_hsa047240.73314970
56Folate biosynthesis_Homo sapiens_hsa007900.71943796
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.68988236
58Tyrosine metabolism_Homo sapiens_hsa003500.66471064
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65628377
60Vibrio cholerae infection_Homo sapiens_hsa051100.64080556
61Proteasome_Homo sapiens_hsa030500.63072990
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62813661
63beta-Alanine metabolism_Homo sapiens_hsa004100.62470283
64Focal adhesion_Homo sapiens_hsa045100.59598698
65Regulation of autophagy_Homo sapiens_hsa041400.58656047
66Insulin resistance_Homo sapiens_hsa049310.56733855
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56663752
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.55366354
69Pancreatic secretion_Homo sapiens_hsa049720.54296262
70Nicotine addiction_Homo sapiens_hsa050330.52808389
71Metabolic pathways_Homo sapiens_hsa011000.49287029
72Steroid biosynthesis_Homo sapiens_hsa001000.49229514
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49187774
74Calcium signaling pathway_Homo sapiens_hsa040200.49132827
75Bile secretion_Homo sapiens_hsa049760.48055963
76Tryptophan metabolism_Homo sapiens_hsa003800.47760743
77Sulfur relay system_Homo sapiens_hsa041220.47642121
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47470334
79PPAR signaling pathway_Homo sapiens_hsa033200.46798684
80Complement and coagulation cascades_Homo sapiens_hsa046100.45417904
81Peroxisome_Homo sapiens_hsa041460.45191720
82Insulin signaling pathway_Homo sapiens_hsa049100.44135805
83Cholinergic synapse_Homo sapiens_hsa047250.43358302
84Amphetamine addiction_Homo sapiens_hsa050310.41068534
85Sulfur metabolism_Homo sapiens_hsa009200.38858185
86Oxytocin signaling pathway_Homo sapiens_hsa049210.38569588
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37497657
88Protein export_Homo sapiens_hsa030600.37329047
89Lysine degradation_Homo sapiens_hsa003100.36730077
90Ether lipid metabolism_Homo sapiens_hsa005650.36436733
91Arginine and proline metabolism_Homo sapiens_hsa003300.35402164
92Gastric acid secretion_Homo sapiens_hsa049710.34417861
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.34338580
94Thyroid hormone synthesis_Homo sapiens_hsa049180.33205433
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31708841
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31577071
97Adherens junction_Homo sapiens_hsa045200.31308647
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.30869077
99Gap junction_Homo sapiens_hsa045400.30668937
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30225376
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.30207112
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29687944
103RNA degradation_Homo sapiens_hsa030180.24612343
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23439249
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22501550
106Mismatch repair_Homo sapiens_hsa034300.20602230
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17903621
108Pentose phosphate pathway_Homo sapiens_hsa000300.16912512
109Glutathione metabolism_Homo sapiens_hsa004800.16757407
110Purine metabolism_Homo sapiens_hsa002300.16492429
111Proteoglycans in cancer_Homo sapiens_hsa052050.13696098
112AMPK signaling pathway_Homo sapiens_hsa041520.13601179
113Hippo signaling pathway_Homo sapiens_hsa043900.12706086
114Circadian entrainment_Homo sapiens_hsa047130.11163999
115Basal cell carcinoma_Homo sapiens_hsa052170.10961303
116cAMP signaling pathway_Homo sapiens_hsa040240.10714200
117ECM-receptor interaction_Homo sapiens_hsa045120.09248229
118Arginine biosynthesis_Homo sapiens_hsa002200.09140537
119Arachidonic acid metabolism_Homo sapiens_hsa005900.08738608
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.08219697
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08037743
122Type II diabetes mellitus_Homo sapiens_hsa049300.05749116
123Renin secretion_Homo sapiens_hsa049240.05677045
124Pyrimidine metabolism_Homo sapiens_hsa002400.04397672
125Fatty acid biosynthesis_Homo sapiens_hsa000610.03421932
126Melanogenesis_Homo sapiens_hsa049160.02053588
127TGF-beta signaling pathway_Homo sapiens_hsa043500.01855103
128Amoebiasis_Homo sapiens_hsa05146-0.0774574
129Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0753706
130Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0714385
131Homologous recombination_Homo sapiens_hsa03440-0.0699369
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0648861
133Glycerolipid metabolism_Homo sapiens_hsa00561-0.0646575
134Taste transduction_Homo sapiens_hsa04742-0.0568975
135FoxO signaling pathway_Homo sapiens_hsa04068-0.0533490
136Ribosome_Homo sapiens_hsa03010-0.0531591
137HTLV-I infection_Homo sapiens_hsa05166-0.0373941
138Circadian rhythm_Homo sapiens_hsa04710-0.0306208
139RNA polymerase_Homo sapiens_hsa03020-0.0250032
140Insulin secretion_Homo sapiens_hsa04911-0.0227561

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