MYC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.06964036
2DNA deamination (GO:0045006)6.01245831
3viral transcription (GO:0019083)5.31021776
4translational termination (GO:0006415)5.14679926
5translational elongation (GO:0006414)4.62146742
6nuclear pore complex assembly (GO:0051292)4.60801890
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41182314
8ribosomal small subunit biogenesis (GO:0042274)4.40086598
9protein targeting to ER (GO:0045047)4.28397216
10cotranslational protein targeting to membrane (GO:0006613)4.27130615
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25738152
12translational initiation (GO:0006413)4.22739005
13maturation of SSU-rRNA (GO:0030490)4.19451787
14formation of translation preinitiation complex (GO:0001731)4.10636952
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.07343162
16telomere maintenance via semi-conservative replication (GO:0032201)4.02657005
17protein localization to endoplasmic reticulum (GO:0070972)4.01301111
18viral life cycle (GO:0019058)4.00613557
19DNA strand elongation involved in DNA replication (GO:0006271)3.96233016
20nuclear pore organization (GO:0006999)3.94825172
21mitotic chromosome condensation (GO:0007076)3.89808573
22cellular protein complex disassembly (GO:0043624)3.89075449
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.83496451
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.83496451
25folic acid metabolic process (GO:0046655)3.83287360
26DNA strand elongation (GO:0022616)3.78891303
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.75815914
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.59605850
29negative regulation of RNA splicing (GO:0033119)3.58555838
30ribosome assembly (GO:0042255)3.57430174
31ribonucleoprotein complex biogenesis (GO:0022613)3.55639182
32DNA unwinding involved in DNA replication (GO:0006268)3.55293345
33protein complex disassembly (GO:0043241)3.52574157
34pore complex assembly (GO:0046931)3.51635053
35rRNA transcription (GO:0009303)3.49105644
36ribosomal large subunit biogenesis (GO:0042273)3.45384408
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.44476443
38telomere maintenance via recombination (GO:0000722)3.37118631
39regulation of translational termination (GO:0006449)3.36282817
40pseudouridine synthesis (GO:0001522)3.35910543
41ribosome biogenesis (GO:0042254)3.35129600
42positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.32055924
43mRNA catabolic process (GO:0006402)3.29139165
44macromolecular complex disassembly (GO:0032984)3.25244979
45peptidyl-arginine omega-N-methylation (GO:0035247)3.24495667
46mitotic sister chromatid segregation (GO:0000070)3.24380986
47rRNA processing (GO:0006364)3.22003455
48DNA replication initiation (GO:0006270)3.20097934
49RNA catabolic process (GO:0006401)3.18751012
50folic acid-containing compound biosynthetic process (GO:0009396)3.17611063
51IMP biosynthetic process (GO:0006188)3.15525889
52antigen processing and presentation of endogenous antigen (GO:0019883)3.14900456
53rRNA metabolic process (GO:0016072)3.09923705
54definitive hemopoiesis (GO:0060216)3.07151046
55nucleobase biosynthetic process (GO:0046112)3.06942551
56regulation of RNA export from nucleus (GO:0046831)3.06283521
57cellular protein complex localization (GO:0034629)3.06000846
58dosage compensation (GO:0007549)3.05248229
59mitotic recombination (GO:0006312)3.02835419
60sister chromatid segregation (GO:0000819)3.02777023
61telomere maintenance via telomere lengthening (GO:0010833)3.01820522
62negative regulation of mRNA processing (GO:0050686)3.00512571
63IMP metabolic process (GO:0046040)2.99892725
64nucleotide-excision repair, DNA gap filling (GO:0006297)2.97026008
65snRNA metabolic process (GO:0016073)2.96684538
66glucocorticoid receptor signaling pathway (GO:0042921)2.96534478
67positive regulation of gamma-delta T cell activation (GO:0046645)2.92487626
68DNA conformation change (GO:0071103)2.90707745
69regulation of mammary gland epithelial cell proliferation (GO:0033599)2.90206062
70proline biosynthetic process (GO:0006561)2.89526234
71regulation of histone H3-K4 methylation (GO:0051569)2.88742344
72regulation of histone H3-K27 methylation (GO:0061085)2.88303941
73protoporphyrinogen IX metabolic process (GO:0046501)2.88224115
74mitotic nuclear envelope disassembly (GO:0007077)2.87045257
75nucleosome disassembly (GO:0006337)2.85351032
76protein-DNA complex disassembly (GO:0032986)2.85351032
77protein localization to chromosome, centromeric region (GO:0071459)2.83468325
78corticosteroid receptor signaling pathway (GO:0031958)2.83251057
79translation (GO:0006412)2.83151997
803-UTR-mediated mRNA stabilization (GO:0070935)2.81966121
81viral mRNA export from host cell nucleus (GO:0046784)2.80657530
82termination of RNA polymerase II transcription (GO:0006369)2.80037465
83pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.79628969
84protein targeting to membrane (GO:0006612)2.77587533
85positive regulation of B cell differentiation (GO:0045579)2.77300406
86nuclear envelope organization (GO:0006998)2.76668261
87protein export from nucleus (GO:0006611)2.74831818
88regulation of gamma-delta T cell differentiation (GO:0045586)2.74790468
89protein complex localization (GO:0031503)2.74594145
90negative regulation of erythrocyte differentiation (GO:0045647)2.73899560
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72566460
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70989066
93pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.69330821
94T cell apoptotic process (GO:0070231)2.68589162
95nucleobase-containing small molecule interconversion (GO:0015949)2.68398832
96positive regulation of DNA-dependent DNA replication (GO:2000105)2.68226182
97mRNA export from nucleus (GO:0006406)2.67239061
98nuclear envelope reassembly (GO:0031468)2.67077357
99mitotic nuclear envelope reassembly (GO:0007084)2.67077357
100positive regulation of osteoblast proliferation (GO:0033690)2.66297705
101transcription from mitochondrial promoter (GO:0006390)2.66266736
102regulation of interleukin-12 biosynthetic process (GO:0045075)2.65801184
103negative regulation of mRNA metabolic process (GO:1903312)2.65155241
104mitochondrial DNA metabolic process (GO:0032042)2.64837357
105maturation of 5.8S rRNA (GO:0000460)2.64766924
106replication fork processing (GO:0031297)2.64309216
107folic acid-containing compound metabolic process (GO:0006760)2.64238312
108antigen processing and presentation via MHC class Ib (GO:0002475)2.63678457
109poly(A)+ mRNA export from nucleus (GO:0016973)2.63523812
110tRNA aminoacylation for protein translation (GO:0006418)2.62838875
111nuclear envelope disassembly (GO:0051081)2.61827541
112membrane disassembly (GO:0030397)2.61827541
113base-excision repair (GO:0006284)2.61136431
114regulation of DNA damage checkpoint (GO:2000001)2.59642920
115RNA export from nucleus (GO:0006405)2.59087533
116regulation of mitochondrial translation (GO:0070129)2.58866933
117pentose-phosphate shunt (GO:0006098)2.57036608
118protein localization to kinetochore (GO:0034501)2.56729540
119snRNA processing (GO:0016180)2.56509814
120negative regulation of phagocytosis (GO:0050765)2.55270829
121protoporphyrinogen IX biosynthetic process (GO:0006782)2.54800567
122DNA topological change (GO:0006265)2.54554859
123tRNA aminoacylation (GO:0043039)2.54061311
124amino acid activation (GO:0043038)2.54061311
125regulation of translational fidelity (GO:0006450)2.53957263
126NIK/NF-kappaB signaling (GO:0038061)2.52715597
127peptidyl-arginine N-methylation (GO:0035246)2.52267259
128peptidyl-arginine methylation (GO:0018216)2.52267259
129Golgi transport vesicle coating (GO:0048200)2.52242520
130COPI coating of Golgi vesicle (GO:0048205)2.52242520
131RNA methylation (GO:0001510)2.52144130
132mRNA cleavage (GO:0006379)2.51227147
133DNA duplex unwinding (GO:0032508)2.50432326
134lymphocyte apoptotic process (GO:0070227)2.49330125
135embryonic process involved in female pregnancy (GO:0060136)2.48940311
136Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48935048
137purine nucleobase biosynthetic process (GO:0009113)2.48884229
138mRNA splicing, via spliceosome (GO:0000398)2.47527849
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.47527849
140cellular component biogenesis (GO:0044085)2.47374450
141tRNA methylation (GO:0030488)2.47056900
142regulation of protein heterodimerization activity (GO:0043497)2.47017902
143DNA geometric change (GO:0032392)2.45919475
144regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45683502
145RNA splicing, via transesterification reactions (GO:0000375)2.45338667
146mitochondrial RNA metabolic process (GO:0000959)2.41365120
147mitotic G1 DNA damage checkpoint (GO:0031571)2.41285877
148spliceosomal snRNP assembly (GO:0000387)2.40643265
149regulation of gamma-delta T cell activation (GO:0046643)2.40478729
150T cell homeostasis (GO:0043029)2.40226658
151negative regulation of B cell apoptotic process (GO:0002903)2.35685120
152telomere maintenance (GO:0000723)2.35342150
153ncRNA processing (GO:0034470)2.34897031
154response to protozoan (GO:0001562)2.34708354
155telomere organization (GO:0032200)2.34319298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.66147954
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89317122
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80681284
4MYC_22102868_ChIP-Seq_BL_Human3.01863304
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.98980572
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56770641
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45997285
8* VDR_21846776_ChIP-Seq_THP-1_Human2.44176511
9* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42595434
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38545117
11TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30346782
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29806506
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19924663
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.10927297
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.10200401
16* NOTCH1_21737748_ChIP-Seq_TLL_Human2.08657416
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08579166
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04906967
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.03185725
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.03039452
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02324725
22SCL_19346495_ChIP-Seq_HPC-7_Human2.01013425
23* XRN2_22483619_ChIP-Seq_HELA_Human1.98721301
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95350521
25VDR_23849224_ChIP-Seq_CD4+_Human1.93980155
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.89691428
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87911124
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84031764
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82956042
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81344425
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80304498
32* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79461478
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76728401
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75875482
35FOXP3_21729870_ChIP-Seq_TREG_Human1.74577988
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73403547
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69958887
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65740981
39DCP1A_22483619_ChIP-Seq_HELA_Human1.62600838
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60852126
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.60250522
42MAF_26560356_Chip-Seq_TH1_Human1.59897972
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59320240
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59179777
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58669609
46CIITA_25753668_ChIP-Seq_RAJI_Human1.57925650
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57079326
48GABP_19822575_ChIP-Seq_HepG2_Human1.56251661
49SPI1_23547873_ChIP-Seq_NB4_Human1.55698187
50* E2F1_21310950_ChIP-Seq_MCF-7_Human1.55071632
51* TTF2_22483619_ChIP-Seq_HELA_Human1.54130475
52* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53450603
53* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51085612
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49696227
55* VDR_24763502_ChIP-Seq_THP-1_Human1.49239999
56MYB_26560356_Chip-Seq_TH2_Human1.48157018
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45970039
58UTX_26944678_Chip-Seq_JUKART_Human1.45730834
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45620884
60* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44354782
61* MYB_26560356_Chip-Seq_TH1_Human1.40928921
62* RUNX1_22412390_ChIP-Seq_EML_Mouse1.40022995
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.39707576
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38142589
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37276857
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37180592
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36119171
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35632830
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32937984
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32086137
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29470525
72KDM5A_27292631_Chip-Seq_BREAST_Human1.29328440
73RACK7_27058665_Chip-Seq_MCF-7_Human1.29235673
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27685519
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27426492
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26924174
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25708294
78* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24585849
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24152715
80LXR_22292898_ChIP-Seq_THP-1_Human1.23958954
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22835262
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22420086
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21655908
84* ELK1_19687146_ChIP-ChIP_HELA_Human1.20430920
85MAF_26560356_Chip-Seq_TH2_Human1.18976287
86* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18896283
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18419897
88NCOR1_26117541_ChIP-Seq_K562_Human1.18300468
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17320987
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15539645
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13293308
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.13030911
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12654852
94* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11463909
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.11165196
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.09797531
97* AR_21909140_ChIP-Seq_LNCAP_Human1.09682934
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09581659
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08741533
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06664310
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06266933
102ATF3_27146783_Chip-Seq_COLON_Human1.05936781
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05624024
104* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04907716
105* KDM2B_26808549_Chip-Seq_DND41_Human1.04802633
106TFEB_21752829_ChIP-Seq_HELA_Human1.04182695
107* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04001959
108* CHD1_26751641_Chip-Seq_LNCaP_Human1.03645342
109* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03384137
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02595029
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02190659
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01664726
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01437943
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00828376
115* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00736661
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00395718
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99940533
118ZNF263_19887448_ChIP-Seq_K562_Human0.99757721
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99645140
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99266478
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98513738
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97843312
123* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97714734
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96606278
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96406331
126* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96325316
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95492645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002396_abnormal_hematopoietic_system3.57823276
2MP0008057_abnormal_DNA_replication3.56228894
3MP0003693_abnormal_embryo_hatching3.07247419
4MP0003763_abnormal_thymus_physiology3.02518628
5MP0005451_abnormal_body_composition2.93571368
6MP0001545_abnormal_hematopoietic_system2.80856861
7MP0005397_hematopoietic_system_phenotyp2.80856861
8MP0004808_abnormal_hematopoietic_stem2.63112961
9MP0000685_abnormal_immune_system2.59571851
10MP0004957_abnormal_blastocyst_morpholog2.50174159
11* MP0010094_abnormal_chromosome_stability2.41478758
12MP0002166_altered_tumor_susceptibility2.34971762
13MP0000490_abnormal_crypts_of2.31103118
14MP0009333_abnormal_splenocyte_physiolog2.29462967
15MP0003111_abnormal_nucleus_morphology2.29179963
16MP0001835_abnormal_antigen_presentation2.28331797
17MP0003077_abnormal_cell_cycle2.27657156
18MP0010352_gastrointestinal_tract_polyps2.25937757
19* MP0002398_abnormal_bone_marrow2.21488791
20MP0004233_abnormal_muscle_weight2.11386963
21MP0009278_abnormal_bone_marrow2.11106671
22MP0003436_decreased_susceptibility_to2.06805197
23MP0008007_abnormal_cellular_replicative2.00555244
24MP0005671_abnormal_response_to1.96403583
25MP0002405_respiratory_system_inflammati1.95875543
26MP0001853_heart_inflammation1.95127405
27MP0001800_abnormal_humoral_immune1.94207799
28MP0000537_abnormal_urethra_morphology1.91240432
29* MP0000689_abnormal_spleen_morphology1.90276032
30MP0005083_abnormal_biliary_tract1.89152027
31MP0008058_abnormal_DNA_repair1.87431307
32* MP0002722_abnormal_immune_system1.86805683
33MP0000465_gastrointestinal_hemorrhage1.86556151
34MP0000703_abnormal_thymus_morphology1.85283769
35MP0002006_tumorigenesis1.84822413
36MP0001873_stomach_inflammation1.84755624
37MP0003315_abnormal_perineum_morphology1.82970984
38MP0005174_abnormal_tail_pigmentation1.80939801
39MP0004185_abnormal_adipocyte_glucose1.73573301
40MP0010155_abnormal_intestine_physiology1.71096278
41* MP0002420_abnormal_adaptive_immunity1.70871231
42* MP0000716_abnormal_immune_system1.69955729
43MP0010307_abnormal_tumor_latency1.68721213
44* MP0001819_abnormal_immune_cell1.67071489
45MP0009785_altered_susceptibility_to1.66325489
46* MP0002452_abnormal_antigen_presenting1.66300227
47MP0002723_abnormal_immune_serum1.65278653
48* MP0002429_abnormal_blood_cell1.64061679
49MP0005075_abnormal_melanosome_morpholog1.60633451
50MP0005025_abnormal_response_to1.60309105
51MP0005000_abnormal_immune_tolerance1.60092446
52MP0003866_abnormal_defecation1.59308142
53* MP0002019_abnormal_tumor_incidence1.58684801
54MP0006054_spinal_hemorrhage1.57950805
55MP0005464_abnormal_platelet_physiology1.55698598
56MP0003303_peritoneal_inflammation1.54541243
57MP0003786_premature_aging1.53892482
58MP0002796_impaired_skin_barrier1.50243807
59MP0005501_abnormal_skin_physiology1.49033676
60MP0003724_increased_susceptibility_to1.41142991
61MP0001790_abnormal_immune_system1.38396381
62MP0005387_immune_system_phenotype1.38396381
63MP0003300_gastrointestinal_ulcer1.34092314
64* MP0000350_abnormal_cell_proliferation1.30548026
65MP0003705_abnormal_hypodermis_morpholog1.30061429
66MP0000858_altered_metastatic_potential1.29943438
67MP0002419_abnormal_innate_immunity1.26552219
68MP0000579_abnormal_nail_morphology1.22554211
69MP0005621_abnormal_cell_physiology1.22212250
70MP0002009_preneoplasia1.19545919
71MP0008932_abnormal_embryonic_tissue1.16795096
72MP0000313_abnormal_cell_death1.16699179
73MP0002148_abnormal_hypersensitivity_rea1.16190977
74MP0010234_abnormal_vibrissa_follicle1.16028921
75MP0006035_abnormal_mitochondrial_morpho1.14028358
76MP0003656_abnormal_erythrocyte_physiolo1.10608793
77MP0005023_abnormal_wound_healing1.08593317
78MP0001845_abnormal_inflammatory_respons1.08271703
79MP0001730_embryonic_growth_arrest1.06009729
80MP0000678_abnormal_parathyroid_gland1.05148790
81MP0003453_abnormal_keratinocyte_physiol1.04911516
82MP0002132_abnormal_respiratory_system1.04646230
83MP0005384_cellular_phenotype1.02990343
84MP0009840_abnormal_foam_cell1.02038269
85MP0003718_maternal_effect1.01470291
86MP0005076_abnormal_cell_differentiation1.00419644
87MP0002933_joint_inflammation1.00315375
88MP0006036_abnormal_mitochondrial_physio0.98807198
89MP0003806_abnormal_nucleotide_metabolis0.98073371
90MP0002095_abnormal_skin_pigmentation0.97623979
91MP0000358_abnormal_cell_content/0.94862573
92MP0001216_abnormal_epidermal_layer0.94275006
93MP0001849_ear_inflammation0.94239586
94* MP0002080_prenatal_lethality0.93771049
95MP0004947_skin_inflammation0.93501059
96MP0001697_abnormal_embryo_size0.92118721
97MP0008961_abnormal_basal_metabolism0.91342284
98MP0001661_extended_life_span0.90815393
99* MP0002086_abnormal_extraembryonic_tissu0.90235902
100MP0005666_abnormal_adipose_tissue0.90152444
101MP0002877_abnormal_melanocyte_morpholog0.89975209
102MP0003567_abnormal_fetal_cardiomyocyte0.86792480
103MP0001533_abnormal_skeleton_physiology0.86118790
104MP0009379_abnormal_foot_pigmentation0.85334815
105MP0000015_abnormal_ear_pigmentation0.85207060
106MP0000477_abnormal_intestine_morphology0.85010406
107MP0000003_abnormal_adipose_tissue0.82564218
108MP0008260_abnormal_autophagy0.82432260
109MP0003448_altered_tumor_morphology0.81848684
110MP0004197_abnormal_fetal_growth/weight/0.81028197
111MP0005380_embryogenesis_phenotype0.80502534
112MP0001672_abnormal_embryogenesis/_devel0.80502534
113MP0000627_abnormal_mammary_gland0.77843823
114* MP0003984_embryonic_growth_retardation0.77065459
115MP0003959_abnormal_lean_body0.75759094
116MP0003943_abnormal_hepatobiliary_system0.75658315
117MP0003566_abnormal_cell_adhesion0.75458673
118MP0004381_abnormal_hair_follicle0.74881567
119* MP0002088_abnormal_embryonic_growth/wei0.74136586
120MP0005375_adipose_tissue_phenotype0.73296391
121* MP0002970_abnormal_white_adipose0.73287034
122MP0001348_abnormal_lacrimal_gland0.72463839
123MP0008995_early_reproductive_senescence0.71901922
124MP0000609_abnormal_liver_physiology0.70229157
125* MP0000598_abnormal_liver_morphology0.67824906
126MP0009672_abnormal_birth_weight0.67596756
127MP0001881_abnormal_mammary_gland0.67535260
128MP0004782_abnormal_surfactant_physiolog0.67297909
129* MP0005220_abnormal_exocrine_pancreas0.67280857
130MP0004858_abnormal_nervous_system0.65765092
131MP0009931_abnormal_skin_appearance0.65703899
132MP0001915_intracranial_hemorrhage0.64919851
133MP0008469_abnormal_protein_level0.64375328
134MP0000371_diluted_coat_color0.64225184
135* MP0002084_abnormal_developmental_patter0.64092644
136MP0009697_abnormal_copulation0.63443672
137MP0004147_increased_porphyrin_level0.63345029
138MP0002060_abnormal_skin_morphology0.63315339
139MP0001663_abnormal_digestive_system0.63172648
140MP0004264_abnormal_extraembryonic_tissu0.61894185
141MP0005390_skeleton_phenotype0.60103714
142MP0002085_abnormal_embryonic_tissue0.58758010
143MP0002075_abnormal_coat/hair_pigmentati0.56344836

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)6.06573148
2Abnormality of cells of the erythroid lineage (HP:0012130)5.99071767
3Microvesicular hepatic steatosis (HP:0001414)5.22274308
4Thrombocytosis (HP:0001894)4.93728369
5Reticulocytopenia (HP:0001896)4.39259004
6Aplastic anemia (HP:0001915)4.20999106
7IgM deficiency (HP:0002850)3.84491131
8Testicular atrophy (HP:0000029)3.83107081
9Elevated erythrocyte sedimentation rate (HP:0003565)3.76990033
10Ragged-red muscle fibers (HP:0003200)3.65322795
11Poikiloderma (HP:0001029)3.41566674
12Chronic otitis media (HP:0000389)3.41564888
13Pallor (HP:0000980)3.36525584
14Petechiae (HP:0000967)3.29233466
15Pustule (HP:0200039)3.18325927
16Reticulocytosis (HP:0001923)3.16703860
17Abnormality of T cell physiology (HP:0011840)3.09785182
18Premature ovarian failure (HP:0008209)3.00017838
19Progressive external ophthalmoplegia (HP:0000590)2.98152984
20Macrocytic anemia (HP:0001972)2.94258635
21Septate vagina (HP:0001153)2.93084629
22Urethral obstruction (HP:0000796)2.91853198
23Hyperacusis (HP:0010780)2.86369550
24Prolonged bleeding time (HP:0003010)2.82392352
25Panhypogammaglobulinemia (HP:0003139)2.80040639
26Recurrent bronchitis (HP:0002837)2.77497951
27Abnormality of T cells (HP:0002843)2.75793117
28Basal cell carcinoma (HP:0002671)2.74596428
29Muscle fiber atrophy (HP:0100295)2.73099025
30Recurrent viral infections (HP:0004429)2.70612333
31Recurrent fungal infections (HP:0002841)2.68909692
32Acute myeloid leukemia (HP:0004808)2.65706175
33Sparse lateral eyebrow (HP:0005338)2.62739087
34Nasal polyposis (HP:0100582)2.60969913
35IgG deficiency (HP:0004315)2.59882195
36IgA deficiency (HP:0002720)2.58642874
37Myelodysplasia (HP:0002863)2.57054300
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55822240
39Acute lymphatic leukemia (HP:0006721)2.55531429
40Reduced antithrombin III activity (HP:0001976)2.55227329
41Oral leukoplakia (HP:0002745)2.55066240
42Trismus (HP:0000211)2.53499579
43Impaired proprioception (HP:0010831)2.50468202
4411 pairs of ribs (HP:0000878)2.50178809
45Squamous cell carcinoma (HP:0002860)2.49957685
46Broad face (HP:0000283)2.49767852
47Abnormality of glycolysis (HP:0004366)2.45506026
48* Lymphoma (HP:0002665)2.45094534
49Chromsome breakage (HP:0040012)2.44258447
50Deviation of the thumb (HP:0009603)2.43579962
51Selective tooth agenesis (HP:0001592)2.42013050
52Multiple enchondromatosis (HP:0005701)2.40943903
53Type 2 muscle fiber atrophy (HP:0003554)2.37267326
54Entropion (HP:0000621)2.36321457
55Premature graying of hair (HP:0002216)2.35699397
56Abnormality of the nasal mucosa (HP:0000433)2.35010579
57Lip pit (HP:0100267)2.34217921
58Colon cancer (HP:0003003)2.34032686
59Dysmetric saccades (HP:0000641)2.33719739
60Type I transferrin isoform profile (HP:0003642)2.33407846
61Impaired platelet aggregation (HP:0003540)2.25228421
62Abnormal platelet function (HP:0011869)2.25228421
63Onycholysis (HP:0001806)2.24328757
64Proximal placement of thumb (HP:0009623)2.22997583
65Albinism (HP:0001022)2.22872050
66Pulmonary fibrosis (HP:0002206)2.21666136
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.21334994
68Myositis (HP:0100614)2.20815462
69Epistaxis (HP:0000421)2.20803125
70Abnormality of B cell number (HP:0010975)2.18806347
71B lymphocytopenia (HP:0010976)2.18806347
72Amaurosis fugax (HP:0100576)2.18267724
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17762033
74Increased density of long bones (HP:0006392)2.16032643
75Fatigue (HP:0012378)2.12077101
76Cellulitis (HP:0100658)2.10516546
77Absent thumb (HP:0009777)2.10116606
78Ankyloglossia (HP:0010296)2.09469864
79Abnormal gallbladder physiology (HP:0012438)2.09242589
80Cholecystitis (HP:0001082)2.09242589
81Viral hepatitis (HP:0006562)2.09183368
82Abnormality of the fingertips (HP:0001211)2.08662870
83Gastrointestinal inflammation (HP:0004386)2.07716944
84Abnormal platelet volume (HP:0011876)2.05780735
85Hypergonadotropic hypogonadism (HP:0000815)2.05325590
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.05148609
87Rough bone trabeculation (HP:0100670)2.04161571
88Long palpebral fissure (HP:0000637)2.03737087
89Increased serum pyruvate (HP:0003542)2.03448576
90Insomnia (HP:0100785)2.03277959
91Short middle phalanx of the 5th finger (HP:0004220)2.02227499
92Birth length less than 3rd percentile (HP:0003561)2.01111625
93Sensory axonal neuropathy (HP:0003390)2.00804503
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.00005768
95Abnormality of the thoracic spine (HP:0100711)1.99173972
96Hypochromic anemia (HP:0001931)1.98672506
97Inflammation of the large intestine (HP:0002037)1.98041144
98Pancytopenia (HP:0001876)1.97301529
99T lymphocytopenia (HP:0005403)1.97250964
100Abnormality of reticulocytes (HP:0004312)1.95006874
101Agammaglobulinemia (HP:0004432)1.94699656
102Tongue fasciculations (HP:0001308)1.93603615
103Abnormality of the prostate (HP:0008775)1.92958708
104Colitis (HP:0002583)1.92928459
105Lymphopenia (HP:0001888)1.91882547
106Achilles tendon contracture (HP:0001771)1.90495427
107Deep philtrum (HP:0002002)1.90056962
108Milia (HP:0001056)1.89425980
109Microretrognathia (HP:0000308)1.88740133
110Seborrheic dermatitis (HP:0001051)1.88489946
111Hypertensive crisis (HP:0100735)1.87391972
112Abnormal hair laboratory examination (HP:0003328)1.87270940
113Cutaneous melanoma (HP:0012056)1.87082882
114Short 5th finger (HP:0009237)1.86586926
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86183051
116Abnormal protein N-linked glycosylation (HP:0012347)1.86183051
117Abnormal protein glycosylation (HP:0012346)1.86183051
118Abnormal glycosylation (HP:0012345)1.86183051
119Severe combined immunodeficiency (HP:0004430)1.86109280
120Abnormality of the anterior horn cell (HP:0006802)1.85227862
121Degeneration of anterior horn cells (HP:0002398)1.85227862
122Ureteral duplication (HP:0000073)1.83480451
123Eczematoid dermatitis (HP:0000976)1.83323711
124Mediastinal lymphadenopathy (HP:0100721)1.82048224
125Abnormality of T cell number (HP:0011839)1.81889341
126Nasolacrimal duct obstruction (HP:0000579)1.81887489
127Deep palmar crease (HP:0006191)1.81822664
128Joint stiffness (HP:0001387)1.81380438
129Pili torti (HP:0003777)1.79256729
130Long eyelashes (HP:0000527)1.79060571
131Hepatitis (HP:0012115)1.78954534
132Thoracic kyphosis (HP:0002942)1.78822263
133Ridged nail (HP:0001807)1.75962201
134Abnormal number of incisors (HP:0011064)1.73958179
135Prostate neoplasm (HP:0100787)1.73899933
136Self-mutilation (HP:0000742)1.72907129
137Increased mean platelet volume (HP:0011877)1.72368371
138Overlapping toe (HP:0001845)1.72272541
139Natal tooth (HP:0000695)1.71923418
140Abnormal trabecular bone morphology (HP:0100671)1.71840453
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71495618
142Facial hemangioma (HP:0000329)1.71142293
143Abnormality of the preputium (HP:0100587)1.70971174
144Increased serum ferritin (HP:0003281)1.70539682
145Exertional dyspnea (HP:0002875)1.70428958
146Prominent nose (HP:0000448)1.69887527
147Progressive muscle weakness (HP:0003323)1.69562143
148Secondary amenorrhea (HP:0000869)1.69164276
149Abnormality of the columella (HP:0009929)1.69117362
150Meningitis (HP:0001287)1.69106752
151Preauricular skin tag (HP:0000384)1.69100972
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68788020
153Micronodular cirrhosis (HP:0001413)1.68705356
154Skin ulcer (HP:0200042)1.67937113
155Elbow flexion contracture (HP:0002987)1.67857630
156Aplasia/Hypoplasia of the thymus (HP:0010515)1.66836193
157Increased IgM level (HP:0003496)1.65449778
158Recurrent abscess formation (HP:0002722)1.64803122
159Broad palm (HP:0001169)1.64785136
160Bone marrow hypocellularity (HP:0005528)1.64674560
161Muscle fibrillation (HP:0010546)1.64397447
162Microcytic anemia (HP:0001935)1.64197382
163Abnormality of oral frenula (HP:0000190)1.64041948
164Abnormality of male internal genitalia (HP:0000022)1.63730728
165Nail dystrophy (HP:0008404)1.63462283
166Abnormality of the Achilles tendon (HP:0005109)1.62927105
167Missing ribs (HP:0000921)1.60508122
168Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.59503019
169Villous atrophy (HP:0011473)1.59332705
170Abnormality of small intestinal villus morphology (HP:0011472)1.59332705
171Abnormal blistering of the skin (HP:0008066)1.56923947
172Increased nuchal translucency (HP:0010880)1.56869175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.95159598
2SMG13.80149267
3MAP4K13.74975225
4NME22.71164749
5FLT32.38597367
6IRAK32.34565841
7VRK22.16399935
8MAP3K112.13221853
9PRPF4B2.09789772
10WEE12.06259365
11TXK2.06145713
12ZAP702.03496243
13RPS6KB22.02410369
14PDK21.89738950
15PKN21.82735942
16KIT1.80816898
17JAK31.80142033
18BTK1.78895374
19TEC1.77614613
20CDC71.75998780
21MAP3K101.71652688
22TGFBR11.62740798
23CDK71.62558402
24STK161.61541536
25EPHA21.58782627
26MAP2K31.57993165
27STK101.57387666
28RPS6KA41.55476392
29LRRK21.54392375
30DYRK31.53602624
31MST1R1.51529004
32EIF2AK11.46015833
33BUB11.44026646
34MATK1.41411574
35MAPKAPK31.40637343
36NME11.39031060
37SIK11.37707266
38AURKA1.37083524
39PBK1.36910892
40* MTOR1.36732724
41TSSK61.35136250
42ACVR1B1.33208888
43CAMK1D1.26098989
44IKBKB1.24135671
45MAP3K61.23834956
46TRIB31.23000174
47* PIM11.22145844
48KDR1.17786005
49PASK1.17738915
50ATR1.13993264
51TAOK11.10045501
52TTK1.07986982
53EIF2AK31.07354305
54BRSK21.06678521
55MKNK11.06453075
56TAOK21.06181782
57SCYL21.05549801
58VRK11.05523943
59CDK41.03334738
60TBK11.02949291
61NEK11.02359399
62BCKDK1.01582259
63TESK21.00447338
64ERN10.99135345
65TRPM70.99116157
66BRD40.97909779
67CSF1R0.97131950
68ITK0.94870850
69CDK80.94817466
70NEK20.94529002
71CSK0.92480515
72SYK0.91961635
73LCK0.91356017
74MAP3K30.91346337
75CHUK0.90953336
76TAOK30.89924453
77CDK60.89357910
78NLK0.86148058
79MAP3K80.85309938
80ICK0.83783703
81TYK20.83605457
82AURKB0.81202494
83RPS6KA60.80854294
84LYN0.80827426
85BLK0.80762627
86MAPK150.78901954
87MKNK20.76379127
88SRPK10.75221565
89DAPK10.75061898
90CCNB10.74959203
91RPS6KL10.73747624
92RPS6KC10.73747624
93TAF10.70372433
94IKBKE0.70040598
95EIF2AK20.69596428
96GRK60.69499325
97CAMK1G0.65507366
98CDK90.65233258
99* CDK20.64959226
100MAP3K130.64462573
101PAK40.64114917
102ARAF0.63369979
103PLK10.62047451
104TNK20.61062430
105HCK0.60981704
106IRAK40.60485235
107MAPKAPK20.60315641
108LATS20.59989150
109MAPK110.59786658
110MAP3K140.59148043
111MAPK40.58872202
112CHEK10.56861737
113ZAK0.56104068
114HIPK20.54458556
115RPS6KA10.54277453
116CDK120.54082542
117ATM0.53093522
118MAP3K10.52962983
119MAP2K20.52880810
120TLK10.52797027
121BRSK10.51602641
122DDR20.50291462
123MAPKAPK50.50205067
124MELK0.49480866
125CLK10.49460033
126ALK0.48647467
127* CDK10.48426014
128TGFBR20.47270613
129* CSNK2A20.46485983
130CDK190.45997008
131CHEK20.45287150
132ILK0.44591489
133RPS6KA50.43554204
134RPS6KB10.43156511
135AKT20.41059814
136IRAK20.40279565
137PRKCI0.40025137
138FGFR40.38967437
139NEK60.36394830
140STK40.35230883
141MARK20.32852376
142AKT10.32541031
143SIK20.31775190
144MAP3K70.30039025
145EPHA30.29868263

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.33575343
2Ribosome_Homo sapiens_hsa030104.05116254
3Mismatch repair_Homo sapiens_hsa034303.36687932
4Base excision repair_Homo sapiens_hsa034103.08485710
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87751842
6Spliceosome_Homo sapiens_hsa030402.67319773
7Primary immunodeficiency_Homo sapiens_hsa053402.20247557
8Nucleotide excision repair_Homo sapiens_hsa034202.18292396
9RNA transport_Homo sapiens_hsa030132.14504862
10Homologous recombination_Homo sapiens_hsa034402.12408524
11RNA polymerase_Homo sapiens_hsa030202.05413657
12One carbon pool by folate_Homo sapiens_hsa006701.96131399
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87528474
14Pyrimidine metabolism_Homo sapiens_hsa002401.80935495
15* Cell cycle_Homo sapiens_hsa041101.74514093
16Proteasome_Homo sapiens_hsa030501.69391937
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67262429
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66212856
19Non-homologous end-joining_Homo sapiens_hsa034501.61698277
20p53 signaling pathway_Homo sapiens_hsa041151.58259101
21Antigen processing and presentation_Homo sapiens_hsa046121.57445352
22Herpes simplex infection_Homo sapiens_hsa051681.54936680
23Fructose and mannose metabolism_Homo sapiens_hsa000511.51423344
24RNA degradation_Homo sapiens_hsa030181.46313520
25Measles_Homo sapiens_hsa051621.46283891
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.44419811
27Carbon metabolism_Homo sapiens_hsa012001.43182439
28Vitamin B6 metabolism_Homo sapiens_hsa007501.40800569
29Fanconi anemia pathway_Homo sapiens_hsa034601.40511994
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35222897
31Lysine degradation_Homo sapiens_hsa003101.27837027
32Legionellosis_Homo sapiens_hsa051341.24395021
33Leishmaniasis_Homo sapiens_hsa051401.23653285
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22582038
35Hematopoietic cell lineage_Homo sapiens_hsa046401.22132545
36* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20778658
37B cell receptor signaling pathway_Homo sapiens_hsa046621.20241256
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19376133
39mRNA surveillance pathway_Homo sapiens_hsa030151.18751271
40Sulfur relay system_Homo sapiens_hsa041221.15881828
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13473023
42Shigellosis_Homo sapiens_hsa051311.12119396
43* Acute myeloid leukemia_Homo sapiens_hsa052211.11696651
44Viral carcinogenesis_Homo sapiens_hsa052031.09748896
45* Epstein-Barr virus infection_Homo sapiens_hsa051691.08743011
46N-Glycan biosynthesis_Homo sapiens_hsa005101.07830017
47Pyruvate metabolism_Homo sapiens_hsa006201.07766225
48* Bladder cancer_Homo sapiens_hsa052191.06866223
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06364854
50Fatty acid biosynthesis_Homo sapiens_hsa000610.99064910
51Apoptosis_Homo sapiens_hsa042100.96910512
52* Central carbon metabolism in cancer_Homo sapiens_hsa052300.96613815
53T cell receptor signaling pathway_Homo sapiens_hsa046600.96372450
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96020372
55* Hepatitis B_Homo sapiens_hsa051610.95740615
56* Chronic myeloid leukemia_Homo sapiens_hsa052200.95722249
57* Jak-STAT signaling pathway_Homo sapiens_hsa046300.94581089
58Allograft rejection_Homo sapiens_hsa053300.93291009
59* HTLV-I infection_Homo sapiens_hsa051660.92690189
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.92454713
61Basal transcription factors_Homo sapiens_hsa030220.89755290
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.89002201
63* Small cell lung cancer_Homo sapiens_hsa052220.87198360
64Alcoholism_Homo sapiens_hsa050340.84618829
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84150245
66Osteoclast differentiation_Homo sapiens_hsa043800.82323224
67Pentose phosphate pathway_Homo sapiens_hsa000300.79801090
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79439314
69Toxoplasmosis_Homo sapiens_hsa051450.77186430
70Viral myocarditis_Homo sapiens_hsa054160.74441544
71Purine metabolism_Homo sapiens_hsa002300.74353479
72Asthma_Homo sapiens_hsa053100.73236535
73Notch signaling pathway_Homo sapiens_hsa043300.70839190
74Influenza A_Homo sapiens_hsa051640.68301402
75Protein export_Homo sapiens_hsa030600.68122350
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67899846
77Prostate cancer_Homo sapiens_hsa052150.66250945
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64436486
79Folate biosynthesis_Homo sapiens_hsa007900.64090864
80Systemic lupus erythematosus_Homo sapiens_hsa053220.63442827
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63196570
82TNF signaling pathway_Homo sapiens_hsa046680.61633967
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59393120
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58970363
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58468065
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58441753
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56864828
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56828622
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56466772
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56068672
91* MicroRNAs in cancer_Homo sapiens_hsa052060.55693739
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55612362
93Pancreatic cancer_Homo sapiens_hsa052120.55366887
94* Thyroid cancer_Homo sapiens_hsa052160.54831226
95Malaria_Homo sapiens_hsa051440.53909170
96Platelet activation_Homo sapiens_hsa046110.52950835
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52623179
98Other glycan degradation_Homo sapiens_hsa005110.50735716
99Biosynthesis of amino acids_Homo sapiens_hsa012300.50008264
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49712161
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47569255
102Pertussis_Homo sapiens_hsa051330.45957661
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45501672
104HIF-1 signaling pathway_Homo sapiens_hsa040660.44798624
105* Colorectal cancer_Homo sapiens_hsa052100.43774591
106Hepatitis C_Homo sapiens_hsa051600.43048570
107AMPK signaling pathway_Homo sapiens_hsa041520.41627121
108Non-small cell lung cancer_Homo sapiens_hsa052230.40793550
109Salmonella infection_Homo sapiens_hsa051320.40109693
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39742718
111Oocyte meiosis_Homo sapiens_hsa041140.39540394
112Selenocompound metabolism_Homo sapiens_hsa004500.38807854
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38778805
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38673146
115Insulin signaling pathway_Homo sapiens_hsa049100.38111827
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.37879426
117Fatty acid metabolism_Homo sapiens_hsa012120.37839788
118Galactose metabolism_Homo sapiens_hsa000520.37505833
119mTOR signaling pathway_Homo sapiens_hsa041500.37236419
120Prolactin signaling pathway_Homo sapiens_hsa049170.37032811
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35809778
122Graft-versus-host disease_Homo sapiens_hsa053320.35482672
123Arginine biosynthesis_Homo sapiens_hsa002200.34382150
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.33597744
125Type I diabetes mellitus_Homo sapiens_hsa049400.33339567
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.33176586
127Glioma_Homo sapiens_hsa052140.32707852
128VEGF signaling pathway_Homo sapiens_hsa043700.30696345
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27683964
130* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27026109
131* Endometrial cancer_Homo sapiens_hsa052130.24491204
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21768104

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