MYCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.93616418
2mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)6.06544204
3positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021106.06544204
4nucleobase catabolic process (GO:0046113)5.87731766
5glial cell proliferation (GO:0014009)5.24468835
6lateral sprouting from an epithelium (GO:0060601)5.10423787
7positive regulation of mitochondrial membrane permeability (GO:0035794)4.48411042
8limb bud formation (GO:0060174)4.48142828
9axonal fasciculation (GO:0007413)4.43000355
10pre-miRNA processing (GO:0031054)4.37146608
11negative regulation of axon guidance (GO:1902668)4.36897973
12mesoderm development (GO:0007498)4.31261009
13negative regulation of axon extension involved in axon guidance (GO:0048843)4.30741318
14positive regulation by symbiont of host defense response (GO:0052509)4.28734540
15modulation by symbiont of host defense response (GO:0052031)4.28734540
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28734540
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28734540
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.28734540
19modulation by symbiont of host immune response (GO:0052553)4.28734540
20establishment of planar polarity (GO:0001736)4.15973447
21establishment of tissue polarity (GO:0007164)4.15973447
22negative regulation of translation, ncRNA-mediated (GO:0040033)4.15569956
23regulation of translation, ncRNA-mediated (GO:0045974)4.15569956
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.15569956
25central nervous system projection neuron axonogenesis (GO:0021952)4.02113601
26neuronal stem cell maintenance (GO:0097150)4.00530205
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99958243
28detection of other organism (GO:0098543)3.95129535
29dendritic spine morphogenesis (GO:0060997)3.94928549
30detection of bacterium (GO:0016045)3.88937177
31spinal cord development (GO:0021510)3.85352139
32layer formation in cerebral cortex (GO:0021819)3.80022839
33cell migration in hindbrain (GO:0021535)3.76257653
34nucleosome disassembly (GO:0006337)3.71432177
35protein-DNA complex disassembly (GO:0032986)3.71432177
36primitive streak formation (GO:0090009)3.69905489
37ganglion development (GO:0061548)3.69902054
38regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.68762897
39histone H3-K36 demethylation (GO:0070544)3.67564212
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.67540875
41paraxial mesoderm development (GO:0048339)3.66921564
42neuron recognition (GO:0008038)3.65198261
43neuron cell-cell adhesion (GO:0007158)3.63515963
44leukocyte migration involved in inflammatory response (GO:0002523)3.57308535
45respiratory burst (GO:0045730)3.56383602
46peptidyl-arginine methylation (GO:0018216)3.54363488
47peptidyl-arginine N-methylation (GO:0035246)3.54363488
48regulation of posttranscriptional gene silencing (GO:0060147)3.53630560
49regulation of gene silencing by miRNA (GO:0060964)3.53630560
50regulation of gene silencing by RNA (GO:0060966)3.53630560
51regulation of hippo signaling (GO:0035330)3.53511805
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46574313
53dopaminergic neuron differentiation (GO:0071542)3.45332762
54positive regulation of gastrulation (GO:2000543)3.44703103
55negative regulation of catenin import into nucleus (GO:0035414)3.36568702
56peptidyl-arginine omega-N-methylation (GO:0035247)3.34042863
57cranial nerve morphogenesis (GO:0021602)3.33963333
58artery development (GO:0060840)3.32445373
59kidney morphogenesis (GO:0060993)3.32001966
60regulation of axon guidance (GO:1902667)3.31292271
61gastrulation with mouth forming second (GO:0001702)3.27124139
62cerebral cortex neuron differentiation (GO:0021895)3.21026235
63negative regulation of oligodendrocyte differentiation (GO:0048715)3.15208402
64negative regulation of axon extension (GO:0030517)3.15025237
65proximal/distal pattern formation (GO:0009954)3.14038356
66regulation of axon extension involved in axon guidance (GO:0048841)3.13517517
67eyelid development in camera-type eye (GO:0061029)3.11494096
68cochlea morphogenesis (GO:0090103)3.10784901
69face development (GO:0060324)3.10725053
70lung morphogenesis (GO:0060425)3.09575080
71negative regulation of glial cell proliferation (GO:0060253)3.03061674
72positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.02530107
73positive regulation of cell cycle G2/M phase transition (GO:1902751)3.02530107
74epithelial cell differentiation involved in prostate gland development (GO:0060742)3.00954742
75neuron projection extension involved in neuron projection guidance (GO:1902284)3.00608781
76axon extension involved in axon guidance (GO:0048846)3.00608781
77gonadal mesoderm development (GO:0007506)21.5820238
78ephrin receptor signaling pathway (GO:0048013)2.98484788
79spinal cord association neuron differentiation (GO:0021527)2.98218722
80dendrite morphogenesis (GO:0048813)2.97808766
81neutrophil mediated immunity (GO:0002446)2.97432209
82regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.97303149
83mesenchyme development (GO:0060485)2.96938828
84negative regulation of microtubule polymerization (GO:0031115)2.96334588
85post-anal tail morphogenesis (GO:0036342)2.94955268
86axon extension (GO:0048675)2.93525597
87negative regulation of transcription by competitive promoter binding (GO:0010944)2.92685745
88hair cycle (GO:0042633)2.92523733
89molting cycle (GO:0042303)2.92523733
90detection of external biotic stimulus (GO:0098581)2.91608329
91L-serine metabolic process (GO:0006563)2.91590338
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89926196
93central nervous system neuron axonogenesis (GO:0021955)2.89847524
94positive regulation of Notch signaling pathway (GO:0045747)2.88485758
95histone arginine methylation (GO:0034969)2.86970126
96detection of biotic stimulus (GO:0009595)2.86309280
97detection of temperature stimulus involved in sensory perception (GO:0050961)2.85825038
98detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.85825038
99hippocampus development (GO:0021766)2.85648555
100cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85420875
101semaphorin-plexin signaling pathway (GO:0071526)2.84543535
102regulation of NFAT protein import into nucleus (GO:0051532)2.84081966
103forebrain neuron differentiation (GO:0021879)2.83872476
104behavioral response to nicotine (GO:0035095)2.83000506
105respiratory tube development (GO:0030323)2.82028077
106negative regulation of RNA splicing (GO:0033119)2.81512865
107desmosome organization (GO:0002934)2.80771538
108hippo signaling (GO:0035329)2.80502702
109collecting duct development (GO:0072044)2.79941182
110epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.78847824
111dorsal/ventral neural tube patterning (GO:0021904)2.75255494
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.74736440
113branching involved in prostate gland morphogenesis (GO:0060442)2.73073281
114histone lysine demethylation (GO:0070076)2.71124173
115negative regulation of epidermis development (GO:0045683)2.70472447
116regulation of catenin import into nucleus (GO:0035412)2.69805976
117retinal ganglion cell axon guidance (GO:0031290)2.68388527
118negative regulation of cell killing (GO:0031342)2.68201563
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68201563
120sex differentiation (GO:0007548)2.68173454
121dendritic cell chemotaxis (GO:0002407)2.67645856
122neutrophil activation involved in immune response (GO:0002283)2.67640642
123regulation of protein heterodimerization activity (GO:0043497)2.67361354
124regulation of growth hormone secretion (GO:0060123)2.66847836
125histone H3-K9 demethylation (GO:0033169)2.66800920
126nucleosome assembly (GO:0006334)2.66570540
127nucleosome organization (GO:0034728)2.66310930
128heterochromatin organization (GO:0070828)2.66192590
129regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.65553158
130dorsal/ventral axis specification (GO:0009950)2.63255923
131intracellular estrogen receptor signaling pathway (GO:0030520)2.63236497
132ectodermal placode formation (GO:0060788)2.62881359
133regulation of DNA methylation (GO:0044030)2.62280973
134prostate gland epithelium morphogenesis (GO:0060740)2.61385300
135protein-DNA complex subunit organization (GO:0071824)2.60984610
136positive regulation of gamma-delta T cell activation (GO:0046645)2.60457926
137protein-DNA complex assembly (GO:0065004)2.60082209
138negative regulation of mRNA processing (GO:0050686)2.58795762
139neuron migration (GO:0001764)2.58489204
140positive regulation of synapse assembly (GO:0051965)2.57852108
141negative regulation of gene silencing (GO:0060969)2.57792358
142microtubule depolymerization (GO:0007019)2.57357304
143regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.56843643
144regulation of somitogenesis (GO:0014807)2.56444109
145hindlimb morphogenesis (GO:0035137)2.55615104
146macrophage activation involved in immune response (GO:0002281)2.55171160
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54965768
148urogenital system development (GO:0001655)2.54714086
149detection of temperature stimulus (GO:0016048)2.54475810
150regulation of mRNA splicing, via spliceosome (GO:0048024)2.54192171
151cell proliferation in forebrain (GO:0021846)2.54136564
152positive regulation of mast cell activation (GO:0033005)2.53442008
153positive regulation of synapse maturation (GO:0090129)2.53321523
154polarized epithelial cell differentiation (GO:0030859)2.52903613
155embryonic hindlimb morphogenesis (GO:0035116)2.52558597
156sympathetic nervous system development (GO:0048485)2.52358575
157establishment or maintenance of monopolar cell polarity (GO:0061339)2.52298333
158establishment of monopolar cell polarity (GO:0061162)2.52298333
159regulation of chromatin binding (GO:0035561)2.52183436
160locomotory exploration behavior (GO:0035641)2.51670493
161positive regulation of growth hormone secretion (GO:0060124)2.50637415
162histone demethylation (GO:0016577)2.50189329
163cerebral cortex radially oriented cell migration (GO:0021799)2.49914451
164lens fiber cell development (GO:0070307)2.49240760
165histone H4 deacetylation (GO:0070933)2.48813444
166hindbrain development (GO:0030902)2.48235150
167activated T cell proliferation (GO:0050798)2.48016124
168cerebellar granule cell differentiation (GO:0021707)2.47156875
169negative regulation of histone methylation (GO:0031061)2.43414197
170regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42767105
171regulation of podosome assembly (GO:0071801)2.41876750
172positive regulation of protein homooligomerization (GO:0032464)2.41601474
173G-protein coupled receptor internalization (GO:0002031)2.40965649
174dendritic cell migration (GO:0036336)2.40020083
175ATP-dependent chromatin remodeling (GO:0043044)2.38504455
176establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36963656
177RNA stabilization (GO:0043489)2.36348503
178mRNA stabilization (GO:0048255)2.36348503
179response to peptidoglycan (GO:0032494)2.35979428
180antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31685679
181modulation by virus of host process (GO:0019054)2.28144761
182detection of molecule of bacterial origin (GO:0032490)2.27785952
183myeloid leukocyte mediated immunity (GO:0002444)2.27441523
184N-acetylneuraminate metabolic process (GO:0006054)2.27087191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.08377123
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82732850
3EZH2_22144423_ChIP-Seq_EOC_Human3.50156393
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78086526
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.71240511
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.64864922
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64767886
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.52144479
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44570010
10MYC_22102868_ChIP-Seq_BL_Human2.41224417
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40519466
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40519466
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40519466
14E2F7_22180533_ChIP-Seq_HELA_Human2.31542731
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.29916066
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17187211
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.16208726
18RING1B_27294783_Chip-Seq_NPCs_Mouse2.12845392
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.12574235
20SOX2_18555785_ChIP-Seq_MESCs_Mouse2.10919471
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09462264
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09462264
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.09272058
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.07113968
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.05319823
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05047141
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04341587
28VDR_21846776_ChIP-Seq_THP-1_Human1.98221160
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98105103
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.96906472
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.94842194
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94037218
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92431434
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91440437
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88987372
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87142942
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83691741
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83129036
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80931814
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.80161002
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79515223
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.77118229
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75879787
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75089718
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68300527
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67326638
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67125183
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65164614
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64768739
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64297768
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.63024019
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62372338
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61859946
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59124350
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58174297
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58044514
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55966293
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54722987
59AHR_22903824_ChIP-Seq_MCF-7_Human1.52235201
60KDM2B_26808549_Chip-Seq_DND41_Human1.51779777
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.50510027
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49422861
63CIITA_25753668_ChIP-Seq_RAJI_Human1.48582294
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48493693
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46948130
66TCF7_22412390_ChIP-Seq_EML_Mouse1.43570066
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43326458
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43103987
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.42076460
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42058540
71KDM2B_26808549_Chip-Seq_K562_Human1.41779228
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41751153
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41016414
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37800893
75SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.37386231
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37253070
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36175401
78UTX_26944678_Chip-Seq_JUKART_Human1.35453501
79RNF2_27304074_Chip-Seq_NSC_Mouse1.35265860
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34751754
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.34528564
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33225325
83TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.32619961
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30209440
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29335587
86XRN2_22483619_ChIP-Seq_HELA_Human1.28905066
87POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28881966
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28283053
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27599307
90ZNF263_19887448_ChIP-Seq_K562_Human1.27434415
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27385353
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24832986
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.23917198
94SPI1_23127762_ChIP-Seq_K562_Human1.23810301
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23591385
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22160034
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19464635
98ZNF274_21170338_ChIP-Seq_K562_Hela1.18725280
99IRF1_19129219_ChIP-ChIP_H3396_Human1.18212712
100MAF_26560356_Chip-Seq_TH2_Human1.17257665
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16359383
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.15367147
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.14676201
104MAF_26560356_Chip-Seq_TH1_Human1.13384849
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12677599
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12622286
107SA1_27219007_Chip-Seq_Bcells_Human1.12266877
108POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12050935
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10950020
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10950020
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.10297157
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09598211
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.08054466
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07746028
115SOX3_22085726_ChIP-Seq_NPCs_Mouse1.07682192
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06483915
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06302184
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05735953
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05511291
120LXR_22292898_ChIP-Seq_THP-1_Human1.05183980
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.05087136
122SMC4_20622854_ChIP-Seq_HELA_Human1.04517630
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04346120
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01971073
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01728499
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.00990185
127REST_21632747_ChIP-Seq_MESCs_Mouse1.00618426
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00443040
129SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00330093
130TTF2_22483619_ChIP-Seq_HELA_Human1.00303428
131MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00113213
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99930414
133SPI1_23547873_ChIP-Seq_NB4_Human0.99378139
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99073590
135ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98782063
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.98161895
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.98110175
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97916633
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97903520
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97819461
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.97117461
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96739771
143MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96686558
144CLOCK_20551151_ChIP-Seq_293T_Human0.95408263
145WDR5_24793694_ChIP-Seq_LNCAP_Human0.95275643
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.94675386
147MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94647909
148SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93880712
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93445714
150NANOG_16153702_ChIP-ChIP_HESCs_Human0.93358146
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93081625
152MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92788793
153P68_20966046_ChIP-Seq_HELA_Human0.92174576
154CREB1_26743006_Chip-Seq_LNCaP_Human0.92073297
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.91447741
156PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91440216
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.91068376
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90243922
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89859887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.93461029
2MP0010030_abnormal_orbit_morphology3.82625745
3MP0005377_hearing/vestibular/ear_phenot3.58070623
4MP0003878_abnormal_ear_physiology3.58070623
5MP0000566_synostosis3.06726832
6MP0009053_abnormal_anal_canal3.00390375
7MP0008789_abnormal_olfactory_epithelium2.99577470
8MP0001188_hyperpigmentation2.96570603
9MP0000778_abnormal_nervous_system2.95518688
10MP0003890_abnormal_embryonic-extraembry2.75237578
11MP0002653_abnormal_ependyma_morphology2.61038627
12MP0002822_catalepsy2.57150354
13MP0005394_taste/olfaction_phenotype2.45493872
14MP0005499_abnormal_olfactory_system2.45493872
15MP0002638_abnormal_pupillary_reflex2.34997384
16MP0008260_abnormal_autophagy2.24842030
17MP0003119_abnormal_digestive_system2.22708121
18MP0003136_yellow_coat_color2.12945229
19MP0006292_abnormal_olfactory_placode2.12022202
20MP0003938_abnormal_ear_development2.11405441
21MP0005248_abnormal_Harderian_gland2.10380958
22MP0010234_abnormal_vibrissa_follicle2.09567266
23MP0003303_peritoneal_inflammation2.04263000
24MP0002233_abnormal_nose_morphology1.99056966
25MP0003941_abnormal_skin_development1.97270278
26MP0003315_abnormal_perineum_morphology1.90609885
27MP0000467_abnormal_esophagus_morphology1.89635186
28MP0005409_darkened_coat_color1.88928594
29MP0000049_abnormal_middle_ear1.85411831
30MP0002098_abnormal_vibrissa_morphology1.84621147
31MP0009379_abnormal_foot_pigmentation1.81742651
32MP0003937_abnormal_limbs/digits/tail_de1.80263972
33MP0004133_heterotaxia1.77637133
34MP0002282_abnormal_trachea_morphology1.76450925
35MP0003861_abnormal_nervous_system1.75385488
36MP0000647_abnormal_sebaceous_gland1.74285701
37MP0005187_abnormal_penis_morphology1.72498291
38MP0003385_abnormal_body_wall1.70184744
39MP0005076_abnormal_cell_differentiation1.66168832
40MP0000579_abnormal_nail_morphology1.64044940
41MP0002249_abnormal_larynx_morphology1.63869237
42MP0002184_abnormal_innervation1.62305016
43MP0001849_ear_inflammation1.60002135
44MP0003755_abnormal_palate_morphology1.59922892
45MP0003942_abnormal_urinary_system1.53365231
46MP0002796_impaired_skin_barrier1.50620040
47MP0000631_abnormal_neuroendocrine_gland1.49570498
48MP0002751_abnormal_autonomic_nervous1.44714803
49MP0002111_abnormal_tail_morphology1.43847012
50MP0002132_abnormal_respiratory_system1.42255942
51MP0001293_anophthalmia1.40053865
52MP0002116_abnormal_craniofacial_bone1.39637431
53MP0002234_abnormal_pharynx_morphology1.38766960
54MP0000762_abnormal_tongue_morphology1.37438653
55MP0002932_abnormal_joint_morphology1.36911198
56MP0001286_abnormal_eye_development1.35937281
57MP0003787_abnormal_imprinting1.35803785
58MP0004885_abnormal_endolymph1.32648840
59MP0003115_abnormal_respiratory_system1.27469642
60MP0005671_abnormal_response_to1.27065522
61MP0001346_abnormal_lacrimal_gland1.26065486
62MP0003121_genomic_imprinting1.24999476
63MP0000534_abnormal_ureter_morphology1.24419672
64MP0002092_abnormal_eye_morphology1.24225204
65MP0003077_abnormal_cell_cycle1.23786194
66MP0004264_abnormal_extraembryonic_tissu1.23319357
67MP0000026_abnormal_inner_ear1.22247376
68MP0000490_abnormal_crypts_of1.21957475
69MP0003111_abnormal_nucleus_morphology1.21944816
70MP0003693_abnormal_embryo_hatching1.20788209
71MP0009250_abnormal_appendicular_skeleto1.20618233
72MP0004858_abnormal_nervous_system1.19534077
73MP0004957_abnormal_blastocyst_morpholog1.19287951
74MP0000516_abnormal_urinary_system1.18720482
75MP0005367_renal/urinary_system_phenotyp1.18720482
76MP0009278_abnormal_bone_marrow1.18398508
77MP0003935_abnormal_craniofacial_develop1.17522492
78MP0010678_abnormal_skin_adnexa1.17381338
79MP0002697_abnormal_eye_size1.16620098
80MP0005451_abnormal_body_composition1.16478269
81MP0004859_abnormal_synaptic_plasticity1.16419184
82MP0002938_white_spotting1.15622072
83MP0000428_abnormal_craniofacial_morphol1.15193341
84MP0002152_abnormal_brain_morphology1.14786657
85MP0002177_abnormal_outer_ear1.13456453
86MP0000462_abnormal_digestive_system1.12729422
87MP0002081_perinatal_lethality1.11917483
88MP0000383_abnormal_hair_follicle1.11195472
89MP0002084_abnormal_developmental_patter1.07543478
90MP0004270_analgesia1.06843341
91MP0000955_abnormal_spinal_cord1.06539936
92MP0002557_abnormal_social/conspecific_i1.04584769
93MP0008961_abnormal_basal_metabolism1.04324142
94MP0001340_abnormal_eyelid_morphology1.04115350
95MP0000432_abnormal_head_morphology1.03679200
96MP0000569_abnormal_digit_pigmentation1.01969439
97MP0001529_abnormal_vocalization1.01586964
98MP0002085_abnormal_embryonic_tissue1.00702384
99MP0003122_maternal_imprinting1.00563009
100MP0003221_abnormal_cardiomyocyte_apopto0.98262257
101MP0003183_abnormal_peptide_metabolism0.97939512
102MP0000377_abnormal_hair_follicle0.97260815
103MP0002009_preneoplasia0.96067706
104MP0003283_abnormal_digestive_organ0.95734323
105MP0000613_abnormal_salivary_gland0.94295143
106MP0004134_abnormal_chest_morphology0.93844518
107MP0001485_abnormal_pinna_reflex0.93040137
108MP0002277_abnormal_respiratory_mucosa0.91810018
109MP0003567_abnormal_fetal_cardiomyocyte0.91605840
110MP0002102_abnormal_ear_morphology0.91409099
111MP0002882_abnormal_neuron_morphology0.90506674
112MP0003724_increased_susceptibility_to0.89453071
113MP0003705_abnormal_hypodermis_morpholog0.87753909
114MP0005423_abnormal_somatic_nervous0.87669538
115MP0002089_abnormal_postnatal_growth/wei0.87632169
116MP0008932_abnormal_embryonic_tissue0.86840135
117MP0002752_abnormal_somatic_nervous0.86776784
118MP0001299_abnormal_eye_distance/0.86208641
119MP0001730_embryonic_growth_arrest0.85983314
120MP0004811_abnormal_neuron_physiology0.85606112
121MP0004197_abnormal_fetal_growth/weight/0.85502199
122MP0005501_abnormal_skin_physiology0.84952917
123MP0009672_abnormal_birth_weight0.84771514
124MP0006276_abnormal_autonomic_nervous0.83989958
125MP0008004_abnormal_stomach_pH0.83503353
126MP0002254_reproductive_system_inflammat0.83199745
127MP0002114_abnormal_axial_skeleton0.82491870
128MP0010307_abnormal_tumor_latency0.81493752
129MP0000733_abnormal_muscle_development0.80790508
130MP0004742_abnormal_vestibular_system0.78446768
131MP0006035_abnormal_mitochondrial_morpho0.78078007
132MP0005380_embryogenesis_phenotype0.77570137
133MP0001672_abnormal_embryogenesis/_devel0.77570137
134MP0003123_paternal_imprinting0.77126996
135MP0001984_abnormal_olfaction0.77008305
136MP0004381_abnormal_hair_follicle0.76802185
137MP0005391_vision/eye_phenotype0.76485839
138MP0002909_abnormal_adrenal_gland0.75605360
139MP0004142_abnormal_muscle_tone0.73573379
140MP0002928_abnormal_bile_duct0.69850651
141MP0003984_embryonic_growth_retardation0.69058600
142MP0000350_abnormal_cell_proliferation0.67653322
143MP0003943_abnormal_hepatobiliary_system0.67056675
144MP0002088_abnormal_embryonic_growth/wei0.66685242

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.66121975
2Abnormal hair whorl (HP:0010721)4.02447474
3Partial duplication of thumb phalanx (HP:0009944)3.73807355
4Recurrent bacterial skin infections (HP:0005406)3.42351512
5Vitreoretinal degeneration (HP:0000655)3.36312688
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.25683521
7Short 4th metacarpal (HP:0010044)3.25683521
8Recurrent abscess formation (HP:0002722)2.91134977
9Oligodactyly (HP:0012165)2.91031935
10Duplication of thumb phalanx (HP:0009942)2.90064334
11Partial duplication of the phalanx of hand (HP:0009999)2.83792391
12Abnormality of the salivary glands (HP:0010286)2.82450319
13Recurrent gram-negative bacterial infections (HP:0005420)2.75239330
14Increased IgE level (HP:0003212)2.73749701
15Abnormality of the intervertebral disk (HP:0005108)2.63470543
16Woolly hair (HP:0002224)2.61451208
17Reticulocytopenia (HP:0001896)2.60172272
18Carpal bone hypoplasia (HP:0001498)2.59144277
19Labial hypoplasia (HP:0000066)2.58556328
20Abnormality of the 4th metacarpal (HP:0010012)2.57622004
21Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.53658239
22Short middle phalanx of the 5th finger (HP:0004220)2.52725480
23Abnormality of the phalanges of the 2nd finger (HP:0009541)2.52148889
24Abnormality of the aortic arch (HP:0012303)2.51636744
25Spina bifida occulta (HP:0003298)2.50246810
26Supernumerary ribs (HP:0005815)2.49733443
27Amyotrophic lateral sclerosis (HP:0007354)2.48595536
28Hepatoblastoma (HP:0002884)2.46799111
29Abnormality of macrophages (HP:0004311)2.46038276
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45418499
31Hypoplastic female external genitalia (HP:0012815)2.44222592
32Renal duplication (HP:0000075)2.43363430
33Anophthalmia (HP:0000528)2.40285544
34Oligodactyly (hands) (HP:0001180)2.40283473
35Intestinal fistula (HP:0100819)2.39804359
36Trigonocephaly (HP:0000243)2.37892031
37Slow-growing hair (HP:0002217)2.34532850
38Abnormality of hair growth rate (HP:0011363)2.34532850
39Abnormality of incisor morphology (HP:0011063)2.34230468
40Absent forearm bone (HP:0003953)2.33646624
41Aplasia involving forearm bones (HP:0009822)2.33646624
42Shoulder girdle muscle weakness (HP:0003547)2.30678499
43Cortical dysplasia (HP:0002539)2.28958682
44Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.28762110
45Hypoplastic labia majora (HP:0000059)2.28725503
46Abnormality of the phalanges of the 5th finger (HP:0004213)2.28471317
47Split foot (HP:0001839)2.26790879
48Abnormality of the diencephalon (HP:0010662)2.25846689
49Supernumerary bones of the axial skeleton (HP:0009144)2.23149673
50Abnormality of the 2nd finger (HP:0004100)2.19644212
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.19205030
52Chronic bronchitis (HP:0004469)2.18915332
53Increased cerebral lipofuscin (HP:0011813)2.18462706
54Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.18152729
55Absent radius (HP:0003974)2.17896272
56Abnormality of the pubic bones (HP:0003172)2.17856063
57Metaphyseal cupping (HP:0003021)2.16908477
58Abnormality of the labia majora (HP:0012881)2.16277393
59Cutaneous finger syndactyly (HP:0010554)2.13246887
60Colon cancer (HP:0003003)2.13063045
61Esophageal atresia (HP:0002032)2.11545235
62Growth hormone deficiency (HP:0000824)2.10220723
63Pachygyria (HP:0001302)2.08219669
64Aqueductal stenosis (HP:0002410)2.07822438
65Neonatal respiratory distress (HP:0002643)2.07285098
66Choanal stenosis (HP:0000452)2.06919384
67Rib fusion (HP:0000902)2.06260756
68Recurrent skin infections (HP:0001581)2.03713364
69Obsessive-compulsive behavior (HP:0000722)2.03470829
70Short 5th finger (HP:0009237)2.03468641
71Natal tooth (HP:0000695)2.02589825
72Metaphyseal dysplasia (HP:0100255)2.02481063
73Vaginal fistula (HP:0004320)2.02254837
74Concave nail (HP:0001598)2.02211316
75Rectal fistula (HP:0100590)2.01546792
76Rectovaginal fistula (HP:0000143)2.01546792
77Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.01452045
78Down-sloping shoulders (HP:0200021)2.01314410
79Hemivertebrae (HP:0002937)2.00872279
80Hyperglycinemia (HP:0002154)1.99204388
81Hypotrichosis (HP:0001006)1.98477746
82Obstructive sleep apnea (HP:0002870)1.97916016
83Anal stenosis (HP:0002025)1.96938689
84Morphological abnormality of the middle ear (HP:0008609)1.96915609
85Facial hemangioma (HP:0000329)1.94858489
86Curly hair (HP:0002212)1.94353948
87Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.94127498
88Short 1st metacarpal (HP:0010034)1.94127498
89Renovascular hypertension (HP:0100817)1.93828706
90Abnormality of the labia minora (HP:0012880)1.93522410
91Pelvic girdle muscle weakness (HP:0003749)1.93399670
92Bronchomalacia (HP:0002780)1.92646510
93Hypoplastic nipples (HP:0002557)1.92417807
94Abnormality of the parietal bone (HP:0002696)1.92177435
95Cutaneous syndactyly (HP:0012725)1.90072139
96Lip pit (HP:0100267)1.89062445
97Abnormality of the parathyroid morphology (HP:0011766)1.88056013
98Long eyelashes (HP:0000527)1.87947284
99Astrocytoma (HP:0009592)1.87563414
100Abnormality of the astrocytes (HP:0100707)1.87563414
101Aplasia involving bones of the upper limbs (HP:0009823)1.86742370
102Aplasia of the phalanges of the hand (HP:0009802)1.86742370
103Aplasia involving bones of the extremities (HP:0009825)1.86742370
104Elfin facies (HP:0004428)1.86728173
105Aplasia/Hypoplasia of the patella (HP:0006498)1.86446121
106Abnormality of the lacrimal duct (HP:0011481)1.85151711
107Shawl scrotum (HP:0000049)1.84197628
108Recurrent cutaneous fungal infections (HP:0011370)1.83663984
109Chronic mucocutaneous candidiasis (HP:0002728)1.83663984
110Abnormality of the columella (HP:0009929)1.83581579
111Apathy (HP:0000741)1.83170943
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83009051
113Hypoplasia of the brainstem (HP:0002365)1.83009051
114Osteomalacia (HP:0002749)1.81367448
115Abnormality of the fingertips (HP:0001211)1.81132442
116High anterior hairline (HP:0009890)1.80683630
117Bilateral microphthalmos (HP:0007633)1.80249454
118Abnormality of the septum pellucidum (HP:0007375)1.79761621
119Aplasia/Hypoplasia of the clavicles (HP:0006710)1.79650809
120Alacrima (HP:0000522)1.79601672
121Microglossia (HP:0000171)1.78817736
122Synostosis of carpal bones (HP:0005048)1.78809300
123Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.78724313
124Patellar aplasia (HP:0006443)1.78396844
125Absent frontal sinuses (HP:0002688)1.78011643
126Hyperacusis (HP:0010780)1.77970463
127Broad thumb (HP:0011304)1.77752882
128Advanced eruption of teeth (HP:0006288)1.77736670
129Impulsivity (HP:0100710)1.77068861
130Germ cell neoplasia (HP:0100728)1.76711541
131Bifid scrotum (HP:0000048)1.76468855
132Renal hypoplasia (HP:0000089)1.75991849
133Cupped ear (HP:0000378)1.74766143
134Absent septum pellucidum (HP:0001331)1.74230378
135Myokymia (HP:0002411)1.73984178
136Diminished motivation (HP:0000745)1.72813785
137Fibular aplasia (HP:0002990)1.72606649
138Septo-optic dysplasia (HP:0100842)1.72485740
139Abnormality of permanent molar morphology (HP:0011071)1.72190149
140Abnormality of the dental root (HP:0006486)1.72190149
141Taurodontia (HP:0000679)1.72190149
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.71638050
143Short phalanx of the thumb (HP:0009660)1.71381576
144Anencephaly (HP:0002323)1.71233657
145Ectopic kidney (HP:0000086)1.70627671
146Chin dimple (HP:0010751)1.70578129
147Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70541870
148Popliteal pterygium (HP:0009756)1.70291260
149Anomalous pulmonary venous return (HP:0010772)1.70206469
150Increased number of teeth (HP:0011069)1.70035027
151Wrist flexion contracture (HP:0001239)1.69858969
152Abnormality of the incisor (HP:0000676)1.69522917
153Abnormality of the labia (HP:0000058)1.68928461
154Stenosis of the external auditory canal (HP:0000402)1.68175366
155Aplasia of the musculature (HP:0100854)1.67122604
156Intestinal atresia (HP:0011100)1.67097637
157Generalized hypotonia (HP:0001290)1.66918861
158Agnosia (HP:0010524)1.66808507
159Urticaria (HP:0001025)1.66734307
160Hamartoma (HP:0010566)1.66455434
161Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.66220929
162Increased neuronal autofluorescent lipopigment (HP:0002074)1.62811644
163Bowel incontinence (HP:0002607)1.62394190
164Obstructive lung disease (HP:0006536)1.62269793
165Chronic obstructive pulmonary disease (HP:0006510)1.62269793
166Gingivitis (HP:0000230)1.59842969
167Abnormality of the nasolacrimal system (HP:0000614)1.59487681
168Deep palmar crease (HP:0006191)1.59390700
169Chromsome breakage (HP:0040012)1.59269614
170Hip dysplasia (HP:0001385)1.58276997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.20419869
2CDK193.84907168
3TYRO33.57345955
4EPHB23.41822636
5RIPK43.18845718
6DYRK23.04079717
7ERBB33.00481393
8PRPF4B2.87474382
9KSR12.56412470
10LATS12.52637916
11CAMK1D2.44482561
12ICK2.37295011
13EPHB12.32231609
14KSR22.16941723
15CAMK1G2.14693372
16FGFR22.06898238
17FES1.94003415
18FGR1.91704332
19BCR1.88785445
20MAPK131.88338201
21UHMK11.87069448
22DYRK31.81701162
23NTRK21.72140162
24SIK31.68625889
25IRAK41.67029531
26DDR21.64955091
27DYRK1B1.64508453
28EPHA21.60793602
29CSK1.54713821
30LATS21.52920532
31MAP3K101.52358777
32ERBB21.49234994
33SRPK11.46682103
34BLK1.44840786
35SIK21.42022476
36NME11.36568206
37MAP3K91.29496977
38CASK1.29432247
39LRRK21.29277455
40PDGFRA1.28651502
41TYK21.28571809
42MINK11.27983632
43TAOK11.23426416
44RIPK11.15341937
45SIK11.13677402
46STK241.12554530
47CDC71.09590518
48DYRK1A1.04833619
49PHKG11.02968349
50PHKG21.02968349
51MAP3K21.02175880
52PASK1.00720694
53FGFR10.98875235
54PLK30.98277814
55LIMK10.97503751
56JAK20.96818621
57TNK20.96494867
58BMX0.96312222
59PAK60.94091456
60MAP3K130.93331526
61MKNK10.89480718
62RPS6KA20.88430131
63EEF2K0.86983521
64SGK4940.86902979
65SGK2230.86902979
66PTK60.86067824
67MATK0.86056770
68MAP2K30.85244755
69CDK120.83508508
70TTK0.81232556
71MAP3K10.79694077
72MAP3K70.79145529
73CDK180.79126374
74BUB10.77286941
75BTK0.77164029
76EPHA40.77111193
77HCK0.77051425
78CSF1R0.76998867
79IRAK20.76897112
80PRKCZ0.76496334
81BRD40.75568870
82FER0.74831962
83EPHA30.74729919
84SMG10.74179199
85CDK30.73815357
86TRIB30.73656722
87CSNK1G30.73038506
88AKT30.72958504
89DAPK20.71965411
90RPS6KA10.71742148
91CSNK1A1L0.71577749
92NEK20.70998795
93CDK150.70698973
94MAP2K70.70424574
95CSNK1G10.70234041
96SGK20.67757700
97CDK140.67565739
98CSNK1G20.66853556
99ROCK10.66133820
100PRKCI0.64937639
101MAP3K60.64587831
102PKN20.63730872
103YES10.62335639
104CDK11A0.62330805
105STK160.61942898
106NTRK30.61670882
107PBK0.60458707
108TNIK0.58846248
109TESK10.58317811
110ATR0.58272102
111ALK0.58064071
112GRK60.57339965
113TESK20.57283684
114PTK20.57154937
115MAPK90.56971456
116CDK50.56865372
117CDK40.56812593
118STK100.56477891
119TGFBR10.56326571
120AURKA0.56266020
121SGK30.55755788
122RPS6KB20.54542715
123MAP4K10.54358834
124RPS6KA40.54186306
125LMTK20.53925005
126AKT20.52967571
127DMPK0.52382609
128STK40.52029819
129GSK3A0.51837012
130STK110.51681178
131MAP2K40.50363776
132BRAF0.50046704
133IRAK10.49948559
134RAF10.49666578
135PKN10.49502717
136CSNK1E0.48673482
137PIM10.47800282
138MAP3K50.47645213
139PAK40.46342275
140INSRR0.46246390
141CDK60.46043374
142MARK20.45943412
143MAPK70.45580868
144ROCK20.45535967
145PDGFRB0.45517474
146CHUK0.45422436
147MAP3K80.45356463
148MAP3K40.45192269
149CAMK40.45128836
150PRKD20.43993068
151WNK30.43916503
152ILK0.42541276
153MST40.42528466
154MTOR0.42504093
155BRSK10.40887359
156MELK0.40661215
157CDK10.38954920
158CDK20.38334301
159FGFR40.37701027
160PAK20.35078215
161TAOK20.34349771
162MKNK20.32837813

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.45100364
2Basal cell carcinoma_Homo sapiens_hsa052173.85259679
3Axon guidance_Homo sapiens_hsa043603.30839402
4Hippo signaling pathway_Homo sapiens_hsa043903.09598596
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.89223600
6Hedgehog signaling pathway_Homo sapiens_hsa043402.82878217
7Notch signaling pathway_Homo sapiens_hsa043302.61394273
8Endometrial cancer_Homo sapiens_hsa052132.32388327
9Spliceosome_Homo sapiens_hsa030402.21248094
10Wnt signaling pathway_Homo sapiens_hsa043102.13802937
11mRNA surveillance pathway_Homo sapiens_hsa030152.10709866
12Colorectal cancer_Homo sapiens_hsa052102.03363115
13Adherens junction_Homo sapiens_hsa045202.00620067
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00276967
15Base excision repair_Homo sapiens_hsa034101.95655676
16Tight junction_Homo sapiens_hsa045301.89566406
17Acute myeloid leukemia_Homo sapiens_hsa052211.86210500
18Leishmaniasis_Homo sapiens_hsa051401.80992681
19Staphylococcus aureus infection_Homo sapiens_hsa051501.79069494
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78690001
21TGF-beta signaling pathway_Homo sapiens_hsa043501.64289054
22Osteoclast differentiation_Homo sapiens_hsa043801.64170628
23MicroRNAs in cancer_Homo sapiens_hsa052061.62413050
24DNA replication_Homo sapiens_hsa030301.58295202
25Tuberculosis_Homo sapiens_hsa051521.56123435
26Melanogenesis_Homo sapiens_hsa049161.55935512
27ErbB signaling pathway_Homo sapiens_hsa040121.45874861
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39936871
29Mismatch repair_Homo sapiens_hsa034301.38476464
30B cell receptor signaling pathway_Homo sapiens_hsa046621.38175807
31Ribosome_Homo sapiens_hsa030101.37571683
32Viral myocarditis_Homo sapiens_hsa054161.35785993
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33666628
34Gap junction_Homo sapiens_hsa045401.33553716
35Bladder cancer_Homo sapiens_hsa052191.32461301
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31243643
37Chemokine signaling pathway_Homo sapiens_hsa040621.30434378
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.30210083
39Oocyte meiosis_Homo sapiens_hsa041141.30033808
40Chronic myeloid leukemia_Homo sapiens_hsa052201.29548025
41Glioma_Homo sapiens_hsa052141.21580499
42mTOR signaling pathway_Homo sapiens_hsa041501.19490889
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19240027
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.16860625
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15554760
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08006105
47Proteoglycans in cancer_Homo sapiens_hsa052051.07619517
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06800957
49Glutamatergic synapse_Homo sapiens_hsa047241.03321017
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02734060
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01482665
52Pathways in cancer_Homo sapiens_hsa052000.98048010
53VEGF signaling pathway_Homo sapiens_hsa043700.97469101
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95950131
55Pancreatic cancer_Homo sapiens_hsa052120.95167751
56Cholinergic synapse_Homo sapiens_hsa047250.95097582
57Renal cell carcinoma_Homo sapiens_hsa052110.94759495
58Steroid biosynthesis_Homo sapiens_hsa001000.93851781
59Dopaminergic synapse_Homo sapiens_hsa047280.91630422
60Non-small cell lung cancer_Homo sapiens_hsa052230.91569008
61Melanoma_Homo sapiens_hsa052180.91032853
62Estrogen signaling pathway_Homo sapiens_hsa049150.89681505
63RNA transport_Homo sapiens_hsa030130.89093848
64Epstein-Barr virus infection_Homo sapiens_hsa051690.88912671
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88521834
66Herpes simplex infection_Homo sapiens_hsa051680.84234197
67Prostate cancer_Homo sapiens_hsa052150.84190851
68Phagosome_Homo sapiens_hsa041450.82786498
69Prion diseases_Homo sapiens_hsa050200.82527285
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81899273
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81357754
72GnRH signaling pathway_Homo sapiens_hsa049120.80682414
73Small cell lung cancer_Homo sapiens_hsa052220.80607972
74Influenza A_Homo sapiens_hsa051640.79212167
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79210015
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78462228
77AMPK signaling pathway_Homo sapiens_hsa041520.78239870
78Hepatitis B_Homo sapiens_hsa051610.76604408
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76228526
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75731466
81Prolactin signaling pathway_Homo sapiens_hsa049170.73642745
82Apoptosis_Homo sapiens_hsa042100.73395933
83Inositol phosphate metabolism_Homo sapiens_hsa005620.73288849
84T cell receptor signaling pathway_Homo sapiens_hsa046600.72864858
85Lysine degradation_Homo sapiens_hsa003100.71717004
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71582005
87Alcoholism_Homo sapiens_hsa050340.71498651
88Fanconi anemia pathway_Homo sapiens_hsa034600.71078397
89Galactose metabolism_Homo sapiens_hsa000520.71005693
90Hepatitis C_Homo sapiens_hsa051600.70419640
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70256523
92Cell cycle_Homo sapiens_hsa041100.69859290
93Type II diabetes mellitus_Homo sapiens_hsa049300.69831122
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69760866
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69231828
96Choline metabolism in cancer_Homo sapiens_hsa052310.67766268
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.67085164
98HTLV-I infection_Homo sapiens_hsa051660.66618799
99HIF-1 signaling pathway_Homo sapiens_hsa040660.66351681
100Fatty acid biosynthesis_Homo sapiens_hsa000610.65128176
101Non-homologous end-joining_Homo sapiens_hsa034500.65039042
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64987778
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64711300
104Viral carcinogenesis_Homo sapiens_hsa052030.63488386
105Rap1 signaling pathway_Homo sapiens_hsa040150.62466776
106Long-term depression_Homo sapiens_hsa047300.62208390
107Basal transcription factors_Homo sapiens_hsa030220.58379747
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58171044
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57369115
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.57338270
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56970616
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56469878
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55969684
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55257730
115Serotonergic synapse_Homo sapiens_hsa047260.54060386
116Nicotine addiction_Homo sapiens_hsa050330.53660705
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.52740953
118GABAergic synapse_Homo sapiens_hsa047270.52066331
119Linoleic acid metabolism_Homo sapiens_hsa005910.51513684
120Cocaine addiction_Homo sapiens_hsa050300.51441836
121Measles_Homo sapiens_hsa051620.50497432
122p53 signaling pathway_Homo sapiens_hsa041150.49633088
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.49314275
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48848841
125Ras signaling pathway_Homo sapiens_hsa040140.48518234
126Circadian entrainment_Homo sapiens_hsa047130.48398815
127Insulin signaling pathway_Homo sapiens_hsa049100.48375386
128Focal adhesion_Homo sapiens_hsa045100.48084481
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46929258
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45201475
131Phenylalanine metabolism_Homo sapiens_hsa003600.45015043
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44471562
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.44081649
134Dorso-ventral axis formation_Homo sapiens_hsa043200.43450864
135Oxytocin signaling pathway_Homo sapiens_hsa049210.42612080
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.42339472
137Insulin resistance_Homo sapiens_hsa049310.39712897
138Long-term potentiation_Homo sapiens_hsa047200.39582142
139MAPK signaling pathway_Homo sapiens_hsa040100.39342677
140Thyroid cancer_Homo sapiens_hsa052160.36369635
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36029750
142FoxO signaling pathway_Homo sapiens_hsa040680.35583426
143Systemic lupus erythematosus_Homo sapiens_hsa053220.35370530

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