MYD88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.62918977
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.62918977
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.02561694
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.02561694
5detection of other organism (GO:0098543)4.97151191
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91716027
7detection of bacterium (GO:0016045)4.84481186
8antigen processing and presentation of endogenous antigen (GO:0019883)4.77393489
9positive regulation by symbiont of host defense response (GO:0052509)4.48114878
10modulation by symbiont of host defense response (GO:0052031)4.48114878
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48114878
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48114878
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.48114878
14modulation by symbiont of host immune response (GO:0052553)4.48114878
15detection of external biotic stimulus (GO:0098581)4.19422979
16positive regulation of interferon-alpha production (GO:0032727)4.09797623
17type I interferon signaling pathway (GO:0060337)4.07044371
18cellular response to type I interferon (GO:0071357)4.07044371
19response to type I interferon (GO:0034340)4.05722949
20* immunoglobulin mediated immune response (GO:0016064)3.97942278
21detection of molecule of bacterial origin (GO:0032490)3.93539158
22positive regulation of gamma-delta T cell activation (GO:0046645)3.92424423
23regulation of interferon-alpha production (GO:0032647)3.89155798
24neutrophil activation involved in immune response (GO:0002283)3.86734262
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.74964468
26detection of biotic stimulus (GO:0009595)3.69886475
27interferon-gamma-mediated signaling pathway (GO:0060333)3.66304960
28respiratory burst (GO:0045730)3.60586941
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57405950
30negative regulation of T cell mediated immunity (GO:0002710)3.54447924
31* response to peptidoglycan (GO:0032494)3.54304179
32regulation of mast cell degranulation (GO:0043304)3.54017471
33regulation of interferon-beta biosynthetic process (GO:0045357)3.51862805
34regulation of T cell tolerance induction (GO:0002664)3.49207330
35regulation of B cell receptor signaling pathway (GO:0050855)3.39590928
36response to interleukin-15 (GO:0070672)3.38749073
37negative regulation of leukocyte mediated immunity (GO:0002704)3.38742409
38regulation of tolerance induction (GO:0002643)3.38266326
39leukocyte aggregation (GO:0070486)3.37497264
40defense response to protozoan (GO:0042832)3.34771224
41microglial cell activation (GO:0001774)3.34051789
42response to muramyl dipeptide (GO:0032495)3.32207072
43cellular response to interferon-beta (GO:0035458)3.31950378
44response to interferon-beta (GO:0035456)3.30344705
45macrophage activation involved in immune response (GO:0002281)3.30099468
46negative regulation of erythrocyte differentiation (GO:0045647)3.26393142
47macrophage activation (GO:0042116)3.24047814
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24018947
49interferon-gamma production (GO:0032609)3.23118353
50regulation of mast cell activation involved in immune response (GO:0033006)3.22320182
51germinal center formation (GO:0002467)3.21728167
52positive regulation of mast cell activation (GO:0033005)3.19431883
53polyketide metabolic process (GO:0030638)3.19167396
54doxorubicin metabolic process (GO:0044598)3.19167396
55daunorubicin metabolic process (GO:0044597)3.19167396
56B cell receptor signaling pathway (GO:0050853)3.17534091
57response to interferon-alpha (GO:0035455)3.16531789
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.15380260
59regulation of leukocyte degranulation (GO:0043300)3.14024768
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13979042
61negative thymic T cell selection (GO:0045060)3.13444761
62response to protozoan (GO:0001562)3.12995408
63cellular response to interleukin-15 (GO:0071350)3.11630622
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09235700
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08106108
66* B cell mediated immunity (GO:0019724)3.07964541
67response to host immune response (GO:0052572)3.07888086
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07888086
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07859960
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07499832
71negative regulation of cytokine production involved in immune response (GO:0002719)3.07161841
72regulation of type I interferon-mediated signaling pathway (GO:0060338)3.06406075
73regulation of T-helper 2 cell differentiation (GO:0045628)3.05025484
74regulation of mast cell activation (GO:0033003)3.04795489
75positive regulation of interferon-beta production (GO:0032728)3.04409379
76hydrogen peroxide biosynthetic process (GO:0050665)3.04005612
77positive thymic T cell selection (GO:0045059)3.03849171
78positive regulation of antigen processing and presentation (GO:0002579)3.03732970
79positive regulation of type 2 immune response (GO:0002830)3.02130122
80cellular extravasation (GO:0045123)3.00872698
81negative T cell selection (GO:0043383)3.00635144
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00295779
83negative regulation of innate immune response (GO:0045824)3.00197516
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98305102
85cellular response to exogenous dsRNA (GO:0071360)2.97658791
86leukocyte migration involved in inflammatory response (GO:0002523)2.96646789
87T cell migration (GO:0072678)2.96248959
88NIK/NF-kappaB signaling (GO:0038061)2.94846572
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94403177
90reactive oxygen species biosynthetic process (GO:1903409)2.93079734
91* lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91206575
92antigen processing and presentation via MHC class Ib (GO:0002475)2.91144920
93positive regulation of B cell differentiation (GO:0045579)2.90946418
94negative regulation of interleukin-12 production (GO:0032695)2.90399685
95granulocyte activation (GO:0036230)2.90363067
96* positive regulation of chemokine biosynthetic process (GO:0045080)2.89947118
97positive regulation of mast cell degranulation (GO:0043306)2.89868911
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.89868911
99regulation of response to interferon-gamma (GO:0060330)2.89792016
100neutrophil mediated immunity (GO:0002446)2.89392814
101negative regulation of type 2 immune response (GO:0002829)2.88136931
102positive regulation of defense response to virus by host (GO:0002230)2.88009240
103myeloid cell activation involved in immune response (GO:0002275)2.87737381
104regulation of alpha-beta T cell proliferation (GO:0046640)2.87367955
105neutrophil activation (GO:0042119)2.87285983
106positive regulation of tolerance induction (GO:0002645)2.86889273
107natural killer cell mediated immunity (GO:0002228)2.86425615
108natural killer cell mediated cytotoxicity (GO:0042267)2.86425615
109regulation of type 2 immune response (GO:0002828)2.85998700
110regulation of T cell mediated cytotoxicity (GO:0001914)2.84653585
111positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.83943581
112regulation of B cell differentiation (GO:0045577)2.83102659
113regulation of gamma-delta T cell differentiation (GO:0045586)2.82736328
114negative regulation of phagocytosis (GO:0050765)2.82489096
115regulation of gamma-delta T cell activation (GO:0046643)2.81612819
116JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80312661
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79762535
118response to host (GO:0075136)2.79762535
119response to host defenses (GO:0052200)2.79762535
120regulation of RIG-I signaling pathway (GO:0039535)2.79257907
121negative regulation of viral genome replication (GO:0045071)2.78423854
122regulation of antigen processing and presentation (GO:0002577)2.77808969
123cellular response to interferon-gamma (GO:0071346)2.76955434
124natural killer cell activation (GO:0030101)2.75385065
125* regulation of chemokine biosynthetic process (GO:0045073)2.74204780
126positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73826704
127regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.73653119
128T-helper 1 type immune response (GO:0042088)2.73520824
129production of molecular mediator involved in inflammatory response (GO:0002532)2.73059723
130cellular response to virus (GO:0098586)2.72383398
131positive regulation of natural killer cell differentiation (GO:0032825)2.71798556
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71362407
133cellular response to zinc ion (GO:0071294)2.69560297
134myeloid dendritic cell activation (GO:0001773)2.69547443
135myeloid dendritic cell differentiation (GO:0043011)2.69380232
136positive regulation of isotype switching (GO:0045830)2.68413951
137natural killer cell differentiation (GO:0001779)2.64645216
138pinocytosis (GO:0006907)2.60913105
139positive regulation of protein import into nucleus, translocation (GO:0033160)2.60608332
140dendritic cell differentiation (GO:0097028)2.59370360
141regulation of necroptotic process (GO:0060544)2.58789802
142positive regulation of B cell mediated immunity (GO:0002714)2.57468683
143positive regulation of immunoglobulin mediated immune response (GO:0002891)2.57468683
144regulation of interleukin-2 biosynthetic process (GO:0045076)2.56550830
145regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56168155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.39407562
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.27931692
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.61562936
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68355686
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.40813323
6E2F7_22180533_ChIP-Seq_HELA_Human2.91396272
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89114467
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.86619026
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86208765
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75286877
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74226901
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65854621
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62590404
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57638083
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44080264
16* EGR1_19374776_ChIP-ChIP_THP-1_Human2.35402732
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23572487
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14587785
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12079047
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10369931
21* SPI1_23547873_ChIP-Seq_NB4_Human2.09397238
22SCL_19346495_ChIP-Seq_HPC-7_Human2.07852802
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05054959
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94915624
25MYB_26560356_Chip-Seq_TH2_Human1.92880954
26MAF_26560356_Chip-Seq_TH1_Human1.92363475
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92349833
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91980518
29MYC_22102868_ChIP-Seq_BL_Human1.89758231
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86044604
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84277286
32VDR_21846776_ChIP-Seq_THP-1_Human1.82901502
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.76626643
34MYB_26560356_Chip-Seq_TH1_Human1.75317770
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72051322
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67941665
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66502050
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64082974
39VDR_24787735_ChIP-Seq_THP-1_Human1.60873545
40* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60827635
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60454655
42VDR_24763502_ChIP-Seq_THP-1_Human1.57876378
43UTX_26944678_Chip-Seq_JUKART_Human1.53803954
44* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50282895
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49743100
46RUNX_20019798_ChIP-Seq_JUKART_Human1.45026745
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44871117
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.42220658
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41345910
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.40930372
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40185168
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.39695284
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.38648686
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38426652
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38426652
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38426652
57* TCF7_22412390_ChIP-Seq_EML_Mouse1.36533336
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36174412
59* SPI1_23127762_ChIP-Seq_K562_Human1.35571283
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.34250197
61* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33981104
62GATA1_22025678_ChIP-Seq_K562_Human1.30045841
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28097949
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25872945
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24399469
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24067383
67MAF_26560356_Chip-Seq_TH2_Human1.21343364
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20942835
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20859402
70PU_27001747_Chip-Seq_BMDM_Mouse1.17051693
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13983247
72GATA3_27048872_Chip-Seq_THYMUS_Human1.13858510
73* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11381528
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08572364
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08466460
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08141596
77* BCL6_27268052_Chip-Seq_Bcells_Human1.07511675
78* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06482482
79* GATA1_19941826_ChIP-Seq_K562_Human1.03309944
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03007094
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02782369
82* BCOR_27268052_Chip-Seq_Bcells_Human1.01698644
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99237048
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98446481
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97599356
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97138105
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97004171
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96205608
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95934514
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.95654695
91GATA3_26560356_Chip-Seq_TH2_Human0.94778963
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93992339
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93334896
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93082486
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92158066
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91792621
97NCOR1_26117541_ChIP-Seq_K562_Human0.90876408
98* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90065463
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89817159
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88071388
101TFEB_21752829_ChIP-Seq_HELA_Human0.87727895
102RACK7_27058665_Chip-Seq_MCF-7_Human0.87683426
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85841893
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85510537
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85244948
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.83598859
107RXR_22158963_ChIP-Seq_LIVER_Mouse0.82890282
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82879969
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82506658
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82072452
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81464247
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80653578
113LXR_22292898_ChIP-Seq_THP-1_Human0.79822702
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78858474
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78425604
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76189527
117SPI1_20517297_ChIP-Seq_HL60_Human0.75771743
118E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75031734
119KDM2B_26808549_Chip-Seq_DND41_Human0.74744181
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74035425
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73694612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.07944458
2MP0003436_decreased_susceptibility_to3.68119376
3MP0009785_altered_susceptibility_to3.58777693
4MP0006082_CNS_inflammation2.91952966
5MP0005671_abnormal_response_to2.86823596
6MP0000685_abnormal_immune_system2.86155555
7MP0003724_increased_susceptibility_to2.83239500
8* MP0005000_abnormal_immune_tolerance2.81244804
9* MP0005025_abnormal_response_to2.76959379
10MP0002148_abnormal_hypersensitivity_rea2.74658511
11* MP0005387_immune_system_phenotype2.57868447
12* MP0001790_abnormal_immune_system2.57868447
13* MP0002419_abnormal_innate_immunity2.55443460
14* MP0001800_abnormal_humoral_immune2.53478084
15MP0003303_peritoneal_inflammation2.45311517
16* MP0002452_abnormal_antigen_presenting2.43940774
17* MP0002723_abnormal_immune_serum2.37019568
18* MP0001819_abnormal_immune_cell2.22906714
19* MP0002420_abnormal_adaptive_immunity2.21662127
20MP0002405_respiratory_system_inflammati2.03677271
21MP0001853_heart_inflammation1.99899781
22MP0003763_abnormal_thymus_physiology1.92906062
23MP0004947_skin_inflammation1.89746812
24MP0005464_abnormal_platelet_physiology1.89639954
25MP0009333_abnormal_splenocyte_physiolog1.83703970
26MP0001533_abnormal_skeleton_physiology1.83302527
27* MP0002398_abnormal_bone_marrow1.80884491
28* MP0000716_abnormal_immune_system1.77701624
29* MP0001845_abnormal_inflammatory_respons1.76959625
30* MP0010155_abnormal_intestine_physiology1.76098936
31MP0008260_abnormal_autophagy1.74930012
32MP0002166_altered_tumor_susceptibility1.70491660
33MP0002396_abnormal_hematopoietic_system1.69948206
34MP0002006_tumorigenesis1.68972664
35MP0004510_myositis1.68191885
36MP0000343_altered_response_to1.64059649
37MP0005451_abnormal_body_composition1.63448462
38MP0000858_altered_metastatic_potential1.60136271
39MP0000689_abnormal_spleen_morphology1.60052142
40MP0005397_hematopoietic_system_phenotyp1.59619422
41MP0001545_abnormal_hematopoietic_system1.59619422
42MP0009278_abnormal_bone_marrow1.58494035
43MP0009764_decreased_sensitivity_to1.57922167
44MP0005058_abnormal_lysosome_morphology1.57740604
45MP0003448_altered_tumor_morphology1.57129413
46* MP0008469_abnormal_protein_level1.55337377
47MP0002722_abnormal_immune_system1.54767508
48MP0002254_reproductive_system_inflammat1.53627144
49* MP0002429_abnormal_blood_cell1.52888323
50MP0010352_gastrointestinal_tract_polyps1.49805832
51MP0003191_abnormal_cellular_cholesterol1.47786144
52MP0003300_gastrointestinal_ulcer1.46356019
53MP0005310_abnormal_salivary_gland1.31764294
54MP0003172_abnormal_lysosome_physiology1.28483038
55MP0004808_abnormal_hematopoietic_stem1.26603809
56MP0009840_abnormal_foam_cell1.24658785
57MP0000490_abnormal_crypts_of1.20836679
58MP0003183_abnormal_peptide_metabolism1.20681364
59MP0001873_stomach_inflammation1.20658354
60MP0003075_altered_response_to1.18711997
61MP0003186_abnormal_redox_activity1.16926316
62MP0005075_abnormal_melanosome_morpholog1.15718132
63MP0004883_abnormal_blood_vessel1.14131877
64MP0000465_gastrointestinal_hemorrhage1.11787467
65MP0005023_abnormal_wound_healing1.11293986
66MP0003806_abnormal_nucleotide_metabolis1.11277788
67MP0003566_abnormal_cell_adhesion1.06911137
68MP0002933_joint_inflammation1.06117257
69MP0004782_abnormal_surfactant_physiolog1.05018932
70MP0005390_skeleton_phenotype1.03691836
71MP0003705_abnormal_hypodermis_morpholog1.03636250
72MP0000703_abnormal_thymus_morphology1.02343711
73MP0008004_abnormal_stomach_pH1.02250201
74MP0009763_increased_sensitivity_to1.01786037
75MP0002998_abnormal_bone_remodeling1.01705002
76MP0003011_delayed_dark_adaptation0.95626105
77MP0000604_amyloidosis0.95295834
78MP0002277_abnormal_respiratory_mucosa0.93934977
79MP0001851_eye_inflammation0.93158271
80MP0004381_abnormal_hair_follicle0.93138642
81MP0003690_abnormal_glial_cell0.89266093
82MP0002019_abnormal_tumor_incidence0.86775007
83MP0001663_abnormal_digestive_system0.86389182
84MP0005164_abnormal_response_to0.86164492
85MP0003828_pulmonary_edema0.85506496
86MP0010307_abnormal_tumor_latency0.84674455
87MP0005166_decreased_susceptibility_to0.83055361
88MP0002132_abnormal_respiratory_system0.82463706
89MP0003453_abnormal_keratinocyte_physiol0.81066587
90MP0003866_abnormal_defecation0.80711640
91MP0004264_abnormal_extraembryonic_tissu0.80011181
92MP0000249_abnormal_blood_vessel0.76718126
93MP0005257_abnormal_intraocular_pressure0.75667553
94MP0005319_abnormal_enzyme/_coenzyme0.73899850
95MP0002332_abnormal_exercise_endurance0.72484781
96MP0000609_abnormal_liver_physiology0.72033954
97MP0008057_abnormal_DNA_replication0.71683067
98MP0009765_abnormal_xenobiotic_induced0.71311582
99MP0005167_abnormal_blood-brain_barrier0.70859648
100MP0008438_abnormal_cutaneous_collagen0.70785974
101MP0003795_abnormal_bone_structure0.70165959
102MP0002138_abnormal_hepatobiliary_system0.70134863
103MP0003045_fibrosis0.68881059
104MP0005076_abnormal_cell_differentiation0.67751856
105MP0003091_abnormal_cell_migration0.65736413
106MP0000598_abnormal_liver_morphology0.64746916
107MP0003656_abnormal_erythrocyte_physiolo0.63271787
108MP0008874_decreased_physiological_sensi0.63118758
109MP0003279_aneurysm0.61783945
110MP0001348_abnormal_lacrimal_gland0.59781056
111MP0002136_abnormal_kidney_physiology0.59263879
112MP0002877_abnormal_melanocyte_morpholog0.57437761
113MP0001216_abnormal_epidermal_layer0.56225488
114MP0002139_abnormal_hepatobiliary_system0.50935381
115MP0005381_digestive/alimentary_phenotyp0.49143246
116MP0000015_abnormal_ear_pigmentation0.44825453
117MP0003221_abnormal_cardiomyocyte_apopto0.44614360
118MP0005365_abnormal_bile_salt0.43448591
119MP0002693_abnormal_pancreas_physiology0.42963929

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.02687277
2Eczematoid dermatitis (HP:0000976)5.70736387
3Recurrent abscess formation (HP:0002722)5.55236619
4Recurrent bacterial skin infections (HP:0005406)4.97845634
5Myositis (HP:0100614)4.77713251
6Recurrent gram-negative bacterial infections (HP:0005420)4.41965882
7Orchitis (HP:0100796)4.14486873
8Autoimmune thrombocytopenia (HP:0001973)4.02523628
9Abnormality of macrophages (HP:0004311)3.83537517
10Nasal polyposis (HP:0100582)3.68031925
11Recurrent fungal infections (HP:0002841)3.64979454
12Mediastinal lymphadenopathy (HP:0100721)3.62091606
13Abnormality of the nasal mucosa (HP:0000433)3.57202998
14Chronic otitis media (HP:0000389)3.53784028
15Recurrent viral infections (HP:0004429)3.51895018
16Recurrent skin infections (HP:0001581)3.41827173
17Vacuolated lymphocytes (HP:0001922)3.32578987
18Keratoconjunctivitis (HP:0001096)3.27588833
19Gingivitis (HP:0000230)3.26807383
20Cellulitis (HP:0100658)3.18335521
21Petechiae (HP:0000967)3.14521059
22Systemic lupus erythematosus (HP:0002725)3.12116739
23Interstitial pulmonary disease (HP:0006530)3.03518941
24* Vasculitis (HP:0002633)3.02454262
25Chronic obstructive pulmonary disease (HP:0006510)3.00972557
26Obstructive lung disease (HP:0006536)3.00972557
27Recurrent bronchitis (HP:0002837)2.96914878
28Retrobulbar optic neuritis (HP:0100654)2.88480611
29Optic neuritis (HP:0100653)2.88480611
30Pustule (HP:0200039)2.87895062
31Peritonitis (HP:0002586)2.87382427
32Recurrent cutaneous fungal infections (HP:0011370)2.86913236
33Chronic mucocutaneous candidiasis (HP:0002728)2.86913236
34Periodontitis (HP:0000704)2.83601146
35Stomatitis (HP:0010280)2.80796225
36Leukocytosis (HP:0001974)2.74368258
37Abnormality of T cell physiology (HP:0011840)2.72446228
38Multiple enchondromatosis (HP:0005701)2.70873728
39Abnormality of liposaccharide metabolism (HP:0010968)2.70749863
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.70749863
41Abnormality of glycolipid metabolism (HP:0010969)2.70749863
42Episodic fever (HP:0001954)2.70154320
43Thrombocytosis (HP:0001894)2.66296633
44Meningitis (HP:0001287)2.64504197
45Pulmonary embolism (HP:0002204)2.64272106
46Loss of speech (HP:0002371)2.62749439
47Gangrene (HP:0100758)2.61777728
48Abnormality of T cells (HP:0002843)2.61496004
49Increased cerebral lipofuscin (HP:0011813)2.60619535
50IgM deficiency (HP:0002850)2.59362237
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.55702422
52Reduced antithrombin III activity (HP:0001976)2.51919939
53Hemoptysis (HP:0002105)2.51868451
54Spontaneous hematomas (HP:0007420)2.50932119
55Basal ganglia calcification (HP:0002135)2.50021409
56Agammaglobulinemia (HP:0004432)2.49354734
57* Gingival bleeding (HP:0000225)2.48741290
58Cheilitis (HP:0100825)2.48315338
59Abnormality of T cell number (HP:0011839)2.47925996
60Hypochromic microcytic anemia (HP:0004840)2.43614721
61Combined immunodeficiency (HP:0005387)2.40783212
62Poor head control (HP:0002421)2.39167500
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.38841752
64T lymphocytopenia (HP:0005403)2.37631335
65Chest pain (HP:0100749)2.36387598
66* Anorexia (HP:0002039)2.34413608
67Gastrointestinal infarctions (HP:0005244)2.33829396
68Eosinophilia (HP:0001880)2.32264688
69* Pulmonary infiltrates (HP:0002113)2.30113616
70Sepsis (HP:0100806)2.27626485
71Increased serum ferritin (HP:0003281)2.25595165
72Abnormality of the peritoneum (HP:0002585)2.24838702
73Hepatosplenomegaly (HP:0001433)2.24686513
74Purpura (HP:0000979)2.24251130
75* Hypergammaglobulinemia (HP:0010702)2.22813757
76Autoimmune hemolytic anemia (HP:0001890)2.21260473
77* Urticaria (HP:0001025)2.19500929
78Osteomyelitis (HP:0002754)2.19497040
79Glomerulopathy (HP:0100820)2.19470249
80Arterial thrombosis (HP:0004420)2.18932268
81Abnormality of the prostate (HP:0008775)2.16059845
82Increased IgE level (HP:0003212)2.16053452
83Inflammation of the large intestine (HP:0002037)2.14238714
84Gastrointestinal stroma tumor (HP:0100723)2.12643507
85Granulocytopenia (HP:0001913)2.11796957
86Gastrointestinal inflammation (HP:0004386)2.11507310
87Amyloidosis (HP:0011034)2.09271430
88Axonal loss (HP:0003447)2.09158571
89Skin rash (HP:0000988)2.05760980
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.05217806
91Panhypogammaglobulinemia (HP:0003139)2.04343847
92Lymphopenia (HP:0001888)2.04068243
93* Skin ulcer (HP:0200042)2.03840981
94* Increased IgM level (HP:0003496)2.03572648
95Colitis (HP:0002583)2.03385396
96Recurrent lower respiratory tract infections (HP:0002783)2.03132895
97Abnormality of the pericardium (HP:0001697)2.03053494
98* Epistaxis (HP:0000421)2.02047494
99Keratoconjunctivitis sicca (HP:0001097)2.01732079
100Osteolytic defects of the hand bones (HP:0009699)2.01271266
101Osteolytic defects of the phalanges of the hand (HP:0009771)2.01271266
102Microcytic anemia (HP:0001935)1.99566383
103Emphysema (HP:0002097)1.98115775
104Vertebral compression fractures (HP:0002953)1.98069820
105Acne (HP:0001061)1.97510875
106Prolonged bleeding time (HP:0003010)1.96827465
107Encephalitis (HP:0002383)1.96025630
108Joint swelling (HP:0001386)1.95763295
109Dysostosis multiplex (HP:0000943)1.95573620
110Hypochromic anemia (HP:0001931)1.95370440
111Abnormality of iron homeostasis (HP:0011031)1.94816038
112Abnormality of eosinophils (HP:0001879)1.93318890
113Abnormality of the endocardium (HP:0004306)1.93127445
114Myocardial infarction (HP:0001658)1.92321855
115Restrictive lung disease (HP:0002091)1.91617114
116* Abnormality of the pleura (HP:0002103)1.90685713
117Tetraparesis (HP:0002273)1.90604089
118Hypertensive crisis (HP:0100735)1.90584182
119Acute hepatic failure (HP:0006554)1.90147348
120Hematochezia (HP:0002573)1.90095593
121Premature loss of primary teeth (HP:0006323)1.90040100
122Arthralgia (HP:0002829)1.89747044
123Recurrent pneumonia (HP:0006532)1.89727813
124Amaurosis fugax (HP:0100576)1.87958204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.61762044
2MAP4K13.38597743
3TBK12.82778223
4MAP3K142.74039942
5TYK22.71512441
6BLK2.69825047
7PRPF4B2.66275106
8CDK122.47327774
9TXK2.35727784
10KIT2.35013395
11TGFBR22.34509876
12JAK32.31549745
13IKBKE2.27787091
14CSF1R2.27014572
15ZAP702.26755127
16GRK62.22024499
17STK102.17615021
18IRAK42.14084897
19IKBKB1.95113585
20TNK21.82745997
21CSK1.79015601
22PIM21.75840587
23FGR1.65447669
24TAOK31.59617541
25BTK1.58630707
26FGFR41.58421591
27RIPK41.57957810
28IRAK31.54512769
29MATK1.50561854
30SIK31.50541623
31JAK11.50020608
32NME21.46735092
33SYK1.35004695
34EPHB11.33280967
35TEC1.33244169
36BMPR21.31982667
37MAP2K31.28957098
38KDR1.26979631
39ADRBK21.23565632
40HCK1.22668455
41RPS6KA41.21368553
42FGFR31.20752448
43ITK1.20496737
44MAP3K11.16689763
45FLT31.16488806
46TESK21.12642225
47LCK1.11121786
48CHUK1.09449426
49GRK51.08579369
50RIPK11.00223189
51GRK10.98957204
52MAP3K100.98297814
53LRRK20.97994206
54MOS0.96966846
55LYN0.95789664
56TRIB30.93529998
57MST40.92055681
58MAP3K30.91979718
59PIM10.90968043
60PRKG20.89336523
61GRK70.88349203
62JAK20.87453800
63PRKD20.85247186
64YES10.80779325
65PAK40.79803802
66MAP3K130.77106807
67EPHA30.76518446
68CDC42BPA0.76226465
69KSR20.75693740
70PDK10.74866746
71EIF2AK20.74627161
72NLK0.73374346
73IRAK20.70946625
74NEK90.70818605
75PDPK10.69788657
76SMG10.68128361
77CLK10.67562228
78MAP3K110.67486945
79MARK20.66997626
80TESK10.64443695
81PBK0.64239425
82SIK10.64064339
83PIK3CG0.62008892
84FYN0.60965856
85SIK20.60100261
86FES0.57991691
87MAP3K60.55489537
88PRKCD0.54042561
89BMX0.51265655
90MAPK70.50877657
91MAP3K50.50015241
92STK40.49662795
93MAPK120.48604106
94ABL20.48309981
95MAPKAPK20.47149501
96HIPK20.47020999
97ABL10.46574001
98CDK190.45493228
99MARK30.43874670
100PKN20.41248740
101RPS6KL10.40960589
102RPS6KC10.40960589
103TGFBR10.40736002
104DYRK1B0.40367140
105IGF1R0.36467262
106MAPKAPK30.35861018
107TTN0.34962101
108CDK70.34632110
109PTK2B0.34291496
110CDK40.32949724
111EEF2K0.32942308
112TRPM70.32820177
113EGFR0.32503314
114MAP2K20.32311721
115MAP3K70.31912868
116TIE10.31370116
117MAP2K60.31163962
118MAP3K80.31148846
119PTK60.31130650
120MAPK40.30410898
121MAPK110.30013651
122RPS6KA60.29307929
123ALK0.28789192
124TAOK10.28059763
125IRAK10.27846487
126TAOK20.27767109
127PRKCQ0.26641324
128RET0.24095277

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051402.98142333
2Graft-versus-host disease_Homo sapiens_hsa053322.59820846
3* NF-kappa B signaling pathway_Homo sapiens_hsa040642.53664444
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49353332
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.48093307
6Staphylococcus aureus infection_Homo sapiens_hsa051502.38815474
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30677709
8* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29055836
9Allograft rejection_Homo sapiens_hsa053302.26913224
10Primary immunodeficiency_Homo sapiens_hsa053402.26911311
11* Measles_Homo sapiens_hsa051622.19751088
12Osteoclast differentiation_Homo sapiens_hsa043802.10826294
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.09631248
14Antigen processing and presentation_Homo sapiens_hsa046122.07439525
15* Legionellosis_Homo sapiens_hsa051342.05844490
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86650109
17* Herpes simplex infection_Homo sapiens_hsa051681.84669986
18* Malaria_Homo sapiens_hsa051441.79813536
19Hematopoietic cell lineage_Homo sapiens_hsa046401.78293896
20* Influenza A_Homo sapiens_hsa051641.74063667
21Other glycan degradation_Homo sapiens_hsa005111.73826835
22TNF signaling pathway_Homo sapiens_hsa046681.70475903
23* Pertussis_Homo sapiens_hsa051331.69244408
24B cell receptor signaling pathway_Homo sapiens_hsa046621.63809930
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62333913
26* Tuberculosis_Homo sapiens_hsa051521.55367067
27* Toxoplasmosis_Homo sapiens_hsa051451.51624150
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.48834235
29Asthma_Homo sapiens_hsa053101.48425109
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.45279607
31Apoptosis_Homo sapiens_hsa042101.44153299
32* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40871935
33Shigellosis_Homo sapiens_hsa051311.35083481
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32217871
35Lysosome_Homo sapiens_hsa041421.31157280
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29912016
37T cell receptor signaling pathway_Homo sapiens_hsa046601.24266717
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.17146518
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15948531
40Acute myeloid leukemia_Homo sapiens_hsa052211.15871131
41Rheumatoid arthritis_Homo sapiens_hsa053231.15673468
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15237154
43* Salmonella infection_Homo sapiens_hsa051321.13199130
44Type I diabetes mellitus_Homo sapiens_hsa049401.12398414
45Hepatitis C_Homo sapiens_hsa051601.10798398
46Viral myocarditis_Homo sapiens_hsa054161.08789116
47* Hepatitis B_Homo sapiens_hsa051611.04619568
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03247042
49Chemokine signaling pathway_Homo sapiens_hsa040621.01900724
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97267543
51* African trypanosomiasis_Homo sapiens_hsa051430.96513884
52Caffeine metabolism_Homo sapiens_hsa002320.90910687
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87517559
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86595380
55Autoimmune thyroid disease_Homo sapiens_hsa053200.86121211
56Phagosome_Homo sapiens_hsa041450.85757380
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82787721
58Non-small cell lung cancer_Homo sapiens_hsa052230.82528683
59Complement and coagulation cascades_Homo sapiens_hsa046100.79011101
60DNA replication_Homo sapiens_hsa030300.78403661
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75130143
62Pentose phosphate pathway_Homo sapiens_hsa000300.73312229
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72720679
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70971455
65Galactose metabolism_Homo sapiens_hsa000520.69274971
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68322751
67Ribosome_Homo sapiens_hsa030100.68065241
68Pancreatic cancer_Homo sapiens_hsa052120.66979762
69Platelet activation_Homo sapiens_hsa046110.65386742
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65170550
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65146685
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65052732
73Chronic myeloid leukemia_Homo sapiens_hsa052200.65051159
74Proteasome_Homo sapiens_hsa030500.64649055
75Epstein-Barr virus infection_Homo sapiens_hsa051690.64604361
76Amoebiasis_Homo sapiens_hsa051460.64120329
77p53 signaling pathway_Homo sapiens_hsa041150.63817393
78Endocytosis_Homo sapiens_hsa041440.60277965
79Viral carcinogenesis_Homo sapiens_hsa052030.58786613
80Small cell lung cancer_Homo sapiens_hsa052220.58208101
81Fructose and mannose metabolism_Homo sapiens_hsa000510.57497714
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.55848698
83Prolactin signaling pathway_Homo sapiens_hsa049170.55548115
84HTLV-I infection_Homo sapiens_hsa051660.53637792
85Renal cell carcinoma_Homo sapiens_hsa052110.50231082
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48381951
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48376628
88Arachidonic acid metabolism_Homo sapiens_hsa005900.46725004
89Base excision repair_Homo sapiens_hsa034100.43502330
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.42161402
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41782460
92Sulfur relay system_Homo sapiens_hsa041220.41506974
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39468967
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.39272862
95VEGF signaling pathway_Homo sapiens_hsa043700.39048426
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37430296
97Folate biosynthesis_Homo sapiens_hsa007900.36263074
98HIF-1 signaling pathway_Homo sapiens_hsa040660.35627979
99One carbon pool by folate_Homo sapiens_hsa006700.34965414
100FoxO signaling pathway_Homo sapiens_hsa040680.34944177
101Thyroid cancer_Homo sapiens_hsa052160.34493637
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34422641
103Notch signaling pathway_Homo sapiens_hsa043300.34062783
104Choline metabolism in cancer_Homo sapiens_hsa052310.32292604
105Endometrial cancer_Homo sapiens_hsa052130.31110329
106Regulation of autophagy_Homo sapiens_hsa041400.31037366
107Insulin resistance_Homo sapiens_hsa049310.30233947
108Bladder cancer_Homo sapiens_hsa052190.30081080
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29549973
110Renin-angiotensin system_Homo sapiens_hsa046140.28019975
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.27293861
112ABC transporters_Homo sapiens_hsa020100.25744132
113GnRH signaling pathway_Homo sapiens_hsa049120.25221123
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.25134680
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.24826201
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23690975
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22962174
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22345299
119Dorso-ventral axis formation_Homo sapiens_hsa043200.22279067
120Colorectal cancer_Homo sapiens_hsa052100.22265165
121MAPK signaling pathway_Homo sapiens_hsa040100.21141002
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20398952
123mTOR signaling pathway_Homo sapiens_hsa041500.19992165
124Type II diabetes mellitus_Homo sapiens_hsa049300.19733681

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