MYDGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.07183760
2DNA deamination (GO:0045006)5.25225271
3doxorubicin metabolic process (GO:0044598)5.23614908
4daunorubicin metabolic process (GO:0044597)5.23614908
5polyketide metabolic process (GO:0030638)5.23614908
6COPI coating of Golgi vesicle (GO:0048205)4.79978610
7Golgi transport vesicle coating (GO:0048200)4.79978610
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.69047326
9protein targeting to ER (GO:0045047)4.60359363
10cotranslational protein targeting to membrane (GO:0006613)4.60240647
11ribosomal small subunit assembly (GO:0000028)4.50738868
12protein localization to endoplasmic reticulum (GO:0070972)4.41737527
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36040809
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02215837
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.94457663
16proteasome assembly (GO:0043248)3.88890447
17viral transcription (GO:0019083)3.72952457
18protein retention in ER lumen (GO:0006621)3.66249366
19translational termination (GO:0006415)3.62661665
20GDP-mannose metabolic process (GO:0019673)3.52833546
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52826906
22lipopolysaccharide biosynthetic process (GO:0009103)3.51887381
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49917753
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48362265
25protein maturation by protein folding (GO:0022417)3.46460437
26mitotic nuclear envelope reassembly (GO:0007084)3.44423392
27nuclear envelope reassembly (GO:0031468)3.44423392
28translation (GO:0006412)3.43765321
29L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.42065940
30pinocytosis (GO:0006907)3.39637157
31aminoglycoside antibiotic metabolic process (GO:0030647)3.33284691
32negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.32302103
33antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.30957127
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28553302
35ATP synthesis coupled proton transport (GO:0015986)3.28553302
36translational elongation (GO:0006414)3.27767946
37respiratory chain complex IV assembly (GO:0008535)3.25808286
38ribosomal small subunit biogenesis (GO:0042274)3.25715499
39retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16422994
40aldehyde catabolic process (GO:0046185)3.16229996
41pteridine-containing compound biosynthetic process (GO:0042559)3.15973624
42lipopolysaccharide metabolic process (GO:0008653)3.13649201
43protein complex biogenesis (GO:0070271)3.12919833
44telomere maintenance via semi-conservative replication (GO:0032201)3.11927154
45mannosylation (GO:0097502)3.09220335
46extracellular fibril organization (GO:0043206)3.07395604
47proline biosynthetic process (GO:0006561)3.06103840
48regulation of mitochondrial translation (GO:0070129)3.05894566
49antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.02199654
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99890176
51UV protection (GO:0009650)2.99278204
52mitochondrial respiratory chain complex assembly (GO:0033108)2.99218841
53membrane raft organization (GO:0031579)2.98996086
54regulation of cellular amino acid metabolic process (GO:0006521)2.98923738
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.97386188
56NADH dehydrogenase complex assembly (GO:0010257)2.97386188
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97386188
58dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.97221347
59protein targeting to membrane (GO:0006612)2.95739628
60skin morphogenesis (GO:0043589)2.94113691
61viral life cycle (GO:0019058)2.92405124
62L-methionine salvage (GO:0071267)2.91628392
63L-methionine biosynthetic process (GO:0071265)2.91628392
64amino acid salvage (GO:0043102)2.91628392
65nucleotide transmembrane transport (GO:1901679)2.89147134
66Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88906607
67establishment of viral latency (GO:0019043)2.87118191
68COPII vesicle coating (GO:0048208)2.86454556
69protein deneddylation (GO:0000338)2.86012519
70fibril organization (GO:0097435)2.85497743
71type B pancreatic cell proliferation (GO:0044342)2.83497075
72hyaluronan catabolic process (GO:0030214)2.82748422
73DNA strand elongation involved in DNA replication (GO:0006271)2.82406645
74peptidyl-histidine modification (GO:0018202)2.81834590
75barbed-end actin filament capping (GO:0051016)2.80698595
76translational initiation (GO:0006413)2.79987495
77signal transduction involved in cell cycle checkpoint (GO:0072395)2.79826740
78virion attachment to host cell (GO:0019062)2.79780847
79adhesion of symbiont to host cell (GO:0044650)2.79780847
80cullin deneddylation (GO:0010388)2.79319807
81cytochrome complex assembly (GO:0017004)2.79271485
82maturation of SSU-rRNA (GO:0030490)2.78378425
832-deoxyribonucleotide biosynthetic process (GO:0009265)2.78240880
84deoxyribose phosphate biosynthetic process (GO:0046385)2.78240880
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76795498
86negative regulation of ligase activity (GO:0051352)2.76795498
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76370067
88regulation of metalloenzyme activity (GO:0048552)2.76189335
89pseudouridine synthesis (GO:0001522)2.75059884
90protein N-linked glycosylation via asparagine (GO:0018279)2.73950059
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73397810
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.72596766
93adhesion of symbiont to host (GO:0044406)2.72474387
94ribosomal large subunit biogenesis (GO:0042273)2.72144347
95tRNA methylation (GO:0030488)2.71199338
96positive regulation of monocyte chemotaxis (GO:0090026)2.71189560
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70968003
98positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.70818427
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70805205
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70805205
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70657439
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69441049
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69441049
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69441049
105DNA strand elongation (GO:0022616)2.69158394
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.68129304
107termination of RNA polymerase III transcription (GO:0006386)2.68129304
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67411031
109L-phenylalanine metabolic process (GO:0006558)2.67411031
110peptidyl-asparagine modification (GO:0018196)2.66588696
111nucleobase-containing small molecule interconversion (GO:0015949)2.66420154
112cellular protein complex disassembly (GO:0043624)2.65619107
113eosinophil chemotaxis (GO:0048245)2.65614017
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.65069723
115metallo-sulfur cluster assembly (GO:0031163)2.62802348
116iron-sulfur cluster assembly (GO:0016226)2.62802348
117GTP biosynthetic process (GO:0006183)2.62274045
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60999523
119protein autoprocessing (GO:0016540)2.60918979
120respiratory electron transport chain (GO:0022904)2.60808650
121negative regulation of myeloid cell apoptotic process (GO:0033033)2.60232983
122telomere maintenance via recombination (GO:0000722)2.60125984
123heme biosynthetic process (GO:0006783)2.59838659
124nucleotide-sugar biosynthetic process (GO:0009226)2.58096945
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56760225
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.56760225
127pyrimidine nucleoside salvage (GO:0043097)2.56581933
128pyrimidine-containing compound salvage (GO:0008655)2.56581933
129negative regulation of mitochondrion organization (GO:0010823)2.56064349
130pyrimidine nucleoside biosynthetic process (GO:0046134)2.55444134
131electron transport chain (GO:0022900)2.55369279
132L-serine metabolic process (GO:0006563)2.54130555
133regulation of cellular amine metabolic process (GO:0033238)2.53778924
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.53463066
135positive regulation of interleukin-8 secretion (GO:2000484)2.52633522
136positive regulation of ligase activity (GO:0051351)2.51565869
137pentose-phosphate shunt (GO:0006098)2.50152007
138protein localization to endosome (GO:0036010)2.48218542
139positive regulation of cell cycle arrest (GO:0071158)2.48063627
140cell redox homeostasis (GO:0045454)2.46732806
141peptidyl-proline hydroxylation (GO:0019511)2.46334275
142chaperone-mediated protein transport (GO:0072321)2.45992919
143positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45815384
144apoptotic cell clearance (GO:0043277)2.45464012
145activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45373634
1464-hydroxyproline metabolic process (GO:0019471)2.42397079
147endoplasmic reticulum unfolded protein response (GO:0030968)2.41564336
148protein hydroxylation (GO:0018126)2.40599940
149glycosphingolipid catabolic process (GO:0046479)2.39707767
150endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.39559115
151positive regulation of nuclease activity (GO:0032075)2.38078202
152glucose catabolic process (GO:0006007)2.36599538
153response to interferon-beta (GO:0035456)2.35827934
154eosinophil migration (GO:0072677)2.35038298
155regulation of ubiquitin-protein transferase activity (GO:0051438)2.33189791
156macrophage chemotaxis (GO:0048246)2.30717722
157regulation of mitochondrial membrane potential (GO:0051881)2.30467980
158regulation of monocyte chemotaxis (GO:0090025)2.29838734
159purine deoxyribonucleotide catabolic process (GO:0009155)2.28771048
160glial cell migration (GO:0008347)2.28446276
161cellular response to unfolded protein (GO:0034620)2.27289884
162cellular copper ion homeostasis (GO:0006878)2.26920640
163pentose metabolic process (GO:0019321)2.25546910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43821268
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.10973510
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.02943344
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86687038
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69151599
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.55480438
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.54957905
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.54599250
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.16323811
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.10153153
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88524858
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87195789
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.69775014
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59439806
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.57505321
16E2F7_22180533_ChIP-Seq_HELA_Human2.56516932
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56322322
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.55930396
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47305076
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.41974430
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40939236
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36593513
23DCP1A_22483619_ChIP-Seq_HELA_Human2.32769098
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32396533
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30405941
26VDR_23849224_ChIP-Seq_CD4+_Human2.29397339
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28179748
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22438930
29ZNF263_19887448_ChIP-Seq_K562_Human2.20197107
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18075859
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08754330
32GABP_19822575_ChIP-Seq_HepG2_Human2.06625966
33FOXP3_21729870_ChIP-Seq_TREG_Human2.05253029
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04825040
35ELK3_25401928_ChIP-Seq_HUVEC_Human2.03010971
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98254997
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97099802
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92688917
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91866600
40XRN2_22483619_ChIP-Seq_HELA_Human1.88095068
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87261642
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.86126703
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86090535
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.82275269
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82211867
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81889729
47ELK1_19687146_ChIP-ChIP_HELA_Human1.74774493
48LXR_22292898_ChIP-Seq_THP-1_Human1.74472898
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73832886
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72153975
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71573416
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70606976
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70295023
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65110854
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62319353
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.61343632
57TTF2_22483619_ChIP-Seq_HELA_Human1.59787432
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.57717766
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57711327
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48951247
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.47461748
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46995992
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45549892
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.45224825
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44485276
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43215059
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42767151
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41589055
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41412164
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.39488740
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39430317
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37292299
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37157769
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.37005266
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33798855
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33430249
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32317060
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32200657
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31902948
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28957045
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.28946038
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28830320
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27784631
84RACK7_27058665_Chip-Seq_MCF-7_Human1.27759698
85SPI1_23547873_ChIP-Seq_NB4_Human1.23939357
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23680352
87ATF3_27146783_Chip-Seq_COLON_Human1.22178405
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.20603726
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20476662
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20368587
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19568113
92TFEB_21752829_ChIP-Seq_HELA_Human1.15808894
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15397590
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14521149
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13530006
96BCL6_27268052_Chip-Seq_Bcells_Human1.13122859
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11428977
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10826299
99CLOCK_20551151_ChIP-Seq_293T_Human1.10560253
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08991536
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08792242
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07138676
103CIITA_25753668_ChIP-Seq_RAJI_Human1.06900936
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05796958
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05121623
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04458545
107VDR_24763502_ChIP-Seq_THP-1_Human1.03976025
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03775128
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03057213
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02826262
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02345280
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01895941
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00786542
114P68_20966046_ChIP-Seq_HELA_Human1.00278402
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00122128
116KDM5A_27292631_Chip-Seq_BREAST_Human0.99822110
117MYC_22102868_ChIP-Seq_BL_Human0.99679379
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99641827
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98940296
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98864369
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98839050
122BCOR_27268052_Chip-Seq_Bcells_Human0.98808566
123MYC_18940864_ChIP-ChIP_HL60_Human0.98798719
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98436896
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98104997
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97809691
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97763483
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.97514049
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97354131
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96180941
131TP53_22127205_ChIP-Seq_IMR90_Human0.96050525
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95497980
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90634144
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89798345
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.89243497
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84078084
137VDR_21846776_ChIP-Seq_THP-1_Human0.83436098
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83019803
139E2F1_21310950_ChIP-Seq_MCF-7_Human0.82780930
140GATA1_22025678_ChIP-Seq_K562_Human0.81102147
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81011357
142IRF8_21731497_ChIP-ChIP_J774_Mouse0.80686843
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80520943
144MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80176050
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79867475
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79365584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.51825287
2MP0003806_abnormal_nucleotide_metabolis3.26910417
3MP0003693_abnormal_embryo_hatching2.71545412
4MP0009379_abnormal_foot_pigmentation2.62816653
5MP0005365_abnormal_bile_salt2.61309629
6MP0006054_spinal_hemorrhage2.57468080
7MP0005257_abnormal_intraocular_pressure2.54789134
8MP0003186_abnormal_redox_activity2.53637780
9MP0005220_abnormal_exocrine_pancreas2.51517599
10MP0005083_abnormal_biliary_tract2.45765535
11MP0004272_abnormal_basement_membrane2.42433808
12MP0003195_calcinosis2.38487228
13MP0003279_aneurysm2.35009886
14MP0001666_abnormal_nutrient_absorption2.25910251
15MP0009697_abnormal_copulation2.24325006
16MP0005085_abnormal_gallbladder_physiolo2.17739459
17MP0001764_abnormal_homeostasis2.09850940
18MP0005451_abnormal_body_composition2.04625313
19MP0000343_altered_response_to2.04139404
20MP0006082_CNS_inflammation1.99244194
21MP0008004_abnormal_stomach_pH1.99081056
22MP0000678_abnormal_parathyroid_gland1.98948487
23MP0005084_abnormal_gallbladder_morpholo1.92938692
24MP0003705_abnormal_hypodermis_morpholog1.84661163
25MP0003566_abnormal_cell_adhesion1.83619197
26MP0005165_increased_susceptibility_to1.81033004
27MP0005360_urolithiasis1.79919504
28MP0001958_emphysema1.78850694
29MP0003075_altered_response_to1.77777630
30MP0009333_abnormal_splenocyte_physiolog1.74798848
31MP0008438_abnormal_cutaneous_collagen1.70575078
32MP0004957_abnormal_blastocyst_morpholog1.67876353
33MP0003436_decreased_susceptibility_to1.65206995
34MP0006036_abnormal_mitochondrial_physio1.61439413
35MP0005058_abnormal_lysosome_morphology1.59381448
36MP0003724_increased_susceptibility_to1.59355032
37MP0002132_abnormal_respiratory_system1.59108989
38MP0002060_abnormal_skin_morphology1.58233341
39MP0002693_abnormal_pancreas_physiology1.56302997
40MP0009785_altered_susceptibility_to1.52779566
41MP0001243_abnormal_dermal_layer1.46786803
42MP0001986_abnormal_taste_sensitivity1.46769590
43MP0005379_endocrine/exocrine_gland_phen1.46672652
44MP0008260_abnormal_autophagy1.46158869
45MP0005408_hypopigmentation1.45956765
46MP0005636_abnormal_mineral_homeostasis1.45747499
47MP0005023_abnormal_wound_healing1.45574397
48MP0003656_abnormal_erythrocyte_physiolo1.45113154
49MP0000490_abnormal_crypts_of1.43891744
50MP0003950_abnormal_plasma_membrane1.43752988
51MP0010386_abnormal_urinary_bladder1.43413318
52MP0009643_abnormal_urine_homeostasis1.42541038
53MP0003868_abnormal_feces_composition1.40480357
54MP0005332_abnormal_amino_acid1.39070219
55MP0000604_amyloidosis1.38540315
56MP0003448_altered_tumor_morphology1.37741059
57MP0001944_abnormal_pancreas_morphology1.36389677
58MP0004858_abnormal_nervous_system1.35958780
59MP0005075_abnormal_melanosome_morpholog1.35414095
60MP0008875_abnormal_xenobiotic_pharmacok1.32319917
61MP0002148_abnormal_hypersensitivity_rea1.30569569
62MP0001542_abnormal_bone_strength1.24472153
63MP0005275_abnormal_skin_tensile1.22411272
64MP0005623_abnormal_meninges_morphology1.22405824
65MP0004043_abnormal_pH_regulation1.21216226
66MP0000681_abnormal_thyroid_gland1.21128461
67MP0002419_abnormal_innate_immunity1.20684179
68MP0001835_abnormal_antigen_presentation1.20238782
69MP0003183_abnormal_peptide_metabolism1.20123359
70MP0001533_abnormal_skeleton_physiology1.19774717
71MP0008469_abnormal_protein_level1.19537065
72MP0008007_abnormal_cellular_replicative1.18336943
73MP0002396_abnormal_hematopoietic_system1.17209489
74MP0009764_decreased_sensitivity_to1.16664723
75MP0004782_abnormal_surfactant_physiolog1.14842297
76MP0005025_abnormal_response_to1.13955952
77MP0000372_irregular_coat_pigmentation1.13524451
78MP0002938_white_spotting1.12590745
79MP0005319_abnormal_enzyme/_coenzyme1.12520629
80MP0003329_amyloid_beta_deposits1.10785562
81MP0000613_abnormal_salivary_gland1.07893622
82MP0003252_abnormal_bile_duct1.06314930
83MP0008058_abnormal_DNA_repair1.06078704
84MP0003786_premature_aging1.04729607
85MP0003172_abnormal_lysosome_physiology1.04038006
86MP0000858_altered_metastatic_potential1.04024211
87MP0002998_abnormal_bone_remodeling1.03773377
88MP0002138_abnormal_hepatobiliary_system1.03581762
89MP0005164_abnormal_response_to1.03511834
90MP0000685_abnormal_immune_system1.02614408
91MP0009840_abnormal_foam_cell1.02466710
92MP0005166_decreased_susceptibility_to1.00974935
93MP0002163_abnormal_gland_morphology1.00039867
94MP0001845_abnormal_inflammatory_respons0.99653629
95MP0004947_skin_inflammation0.99572505
96MP0000750_abnormal_muscle_regeneration0.99335509
97MP0003303_peritoneal_inflammation0.98844306
98MP0002933_joint_inflammation0.98761701
99MP0005508_abnormal_skeleton_morphology0.98499410
100MP0005503_abnormal_tendon_morphology0.97923628
101MP0008932_abnormal_embryonic_tissue0.96578961
102MP0005671_abnormal_response_to0.96466564
103MP0004510_myositis0.96058432
104MP0003300_gastrointestinal_ulcer0.93317728
105MP0002723_abnormal_immune_serum0.90590471
106MP0002452_abnormal_antigen_presenting0.90422131
107MP0003795_abnormal_bone_structure0.90412617
108MP0002877_abnormal_melanocyte_morpholog0.90311306
109MP0002876_abnormal_thyroid_physiology0.89527045
110MP0010368_abnormal_lymphatic_system0.88873787
111MP0001849_ear_inflammation0.88064252
112MP0005387_immune_system_phenotype0.87880574
113MP0001790_abnormal_immune_system0.87880574
114MP0009763_increased_sensitivity_to0.87591647
115MP0005000_abnormal_immune_tolerance0.87426785
116MP0010329_abnormal_lipoprotein_level0.86439733
117MP0000609_abnormal_liver_physiology0.85704386
118MP0005330_cardiomyopathy0.85542513
119MP0000358_abnormal_cell_content/0.84775257
120MP0000751_myopathy0.84087319
121MP0005464_abnormal_platelet_physiology0.84055708
122MP0009278_abnormal_bone_marrow0.83026329
123MP0001756_abnormal_urination0.82809409
124MP0001881_abnormal_mammary_gland0.82580160
125MP0009384_cardiac_valve_regurgitation0.82138505
126MP0002420_abnormal_adaptive_immunity0.81739857
127MP0003091_abnormal_cell_migration0.81503970
128MP0004147_increased_porphyrin_level0.81409940
129MP0005390_skeleton_phenotype0.81373301
130MP0001819_abnormal_immune_cell0.81234144
131MP0003763_abnormal_thymus_physiology0.81099042
132MP0005377_hearing/vestibular/ear_phenot0.80441602
133MP0003878_abnormal_ear_physiology0.80441602
134MP0002638_abnormal_pupillary_reflex0.80106392
135MP0000598_abnormal_liver_morphology0.79451518
136MP0003011_delayed_dark_adaptation0.79090488
137MP0002295_abnormal_pulmonary_circulatio0.79082183
138MP0001727_abnormal_embryo_implantation0.78975614
139MP0003866_abnormal_defecation0.78802947
140MP0003191_abnormal_cellular_cholesterol0.77678886
141MP0010030_abnormal_orbit_morphology0.77644396
142MP0005376_homeostasis/metabolism_phenot0.77471333
143MP0001853_heart_inflammation0.77185916
144MP0000013_abnormal_adipose_tissue0.76490925
145MP0003077_abnormal_cell_cycle0.75502830
146MP0003453_abnormal_keratinocyte_physiol0.74193402
147MP0010155_abnormal_intestine_physiology0.73830347
148MP0002118_abnormal_lipid_homeostasis0.73825811
149MP0001664_abnormal_digestion0.73701630
150MP0002405_respiratory_system_inflammati0.72810652
151MP0001663_abnormal_digestive_system0.72190201
152MP0005197_abnormal_uvea_morphology0.72097702
153MP0009642_abnormal_blood_homeostasis0.71204623
154MP0004381_abnormal_hair_follicle0.70786746
155MP0005584_abnormal_enzyme/coenzyme_acti0.70732082
156MP0001661_extended_life_span0.70511324
157MP0001545_abnormal_hematopoietic_system0.70201164
158MP0005397_hematopoietic_system_phenotyp0.70201164
159MP0000003_abnormal_adipose_tissue0.68991925
160MP0002429_abnormal_blood_cell0.68922764

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.51603187
2Abnormality of glycolipid metabolism (HP:0010969)4.82896089
3Abnormality of liposaccharide metabolism (HP:0010968)4.82896089
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.82896089
5Type I transferrin isoform profile (HP:0003642)4.08655959
6Hepatic necrosis (HP:0002605)3.95791569
7Protrusio acetabuli (HP:0003179)3.92287138
8Hepatocellular necrosis (HP:0001404)3.69649054
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.69142033
10Abnormal protein N-linked glycosylation (HP:0012347)3.69142033
11Abnormal protein glycosylation (HP:0012346)3.69142033
12Abnormal glycosylation (HP:0012345)3.69142033
13Mitochondrial inheritance (HP:0001427)3.68833502
14Reduced antithrombin III activity (HP:0001976)3.56302699
15Acute necrotizing encephalopathy (HP:0006965)3.51426503
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.49360604
17Abnormal number of erythroid precursors (HP:0012131)3.45560663
18Abnormality of cells of the erythroid lineage (HP:0012130)3.41250104
19Increased hepatocellular lipid droplets (HP:0006565)3.30307764
20Aplastic anemia (HP:0001915)3.29880114
21Hypoglycemic coma (HP:0001325)3.27970943
22Acute encephalopathy (HP:0006846)3.25946966
23Lipid accumulation in hepatocytes (HP:0006561)3.25834586
24Abnormal mitochondria in muscle tissue (HP:0008316)3.23872106
25Increased CSF lactate (HP:0002490)3.21540720
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.14528046
27Generalized aminoaciduria (HP:0002909)3.05658895
28Hypoglycemic seizures (HP:0002173)3.01359821
29Reticulocytopenia (HP:0001896)3.00880915
30Renal Fanconi syndrome (HP:0001994)2.99681647
31Vacuolated lymphocytes (HP:0001922)2.95948576
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95704360
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95704360
34Symptomatic seizures (HP:0011145)2.85906288
35Abnormality of the intrinsic pathway (HP:0010989)2.82982139
36Increased serum lactate (HP:0002151)2.76963063
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73678389
383-Methylglutaconic aciduria (HP:0003535)2.71160838
39Exertional dyspnea (HP:0002875)2.70905776
40Thrombocytosis (HP:0001894)2.70445634
41Achilles tendon contracture (HP:0001771)2.69916813
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64395148
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64395148
44Abnormality of polysaccharide metabolism (HP:0011012)2.64395148
45J-shaped sella turcica (HP:0002680)2.58743187
46Progressive macrocephaly (HP:0004481)2.56841448
47Increased intramyocellular lipid droplets (HP:0012240)2.55909072
48Prolonged neonatal jaundice (HP:0006579)2.55529093
49Abnormal gallbladder physiology (HP:0012438)2.55482898
50Cholecystitis (HP:0001082)2.55482898
51Beaking of vertebral bodies (HP:0004568)2.54464006
52Opisthotonus (HP:0002179)2.50464138
53Atrophic scars (HP:0001075)2.49245682
54Abnormality of urine glucose concentration (HP:0011016)2.48704312
55Glycosuria (HP:0003076)2.48704312
56Abnormality of dentin (HP:0010299)2.48575895
57Mucopolysacchariduria (HP:0008155)2.47723235
58Urinary glycosaminoglycan excretion (HP:0003541)2.47723235
59Cerebral edema (HP:0002181)2.46796195
60Distal upper limb amyotrophy (HP:0007149)2.45256794
61Upper limb amyotrophy (HP:0009129)2.45256794
62Elbow flexion contracture (HP:0002987)2.44977400
63Abnormality of the Achilles tendon (HP:0005109)2.44904414
64Lactic acidosis (HP:0003128)2.43741901
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41127876
66Ankle contracture (HP:0006466)2.38748175
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37725058
68Dicarboxylic aciduria (HP:0003215)2.37725058
69Reduced subcutaneous adipose tissue (HP:0003758)2.37179004
70Hepatosplenomegaly (HP:0001433)2.36439131
71Increased muscle lipid content (HP:0009058)2.35676501
72Joint stiffness (HP:0001387)2.35492794
73Nonimmune hydrops fetalis (HP:0001790)2.34988779
74Microvesicular hepatic steatosis (HP:0001414)2.34444544
75Prolonged partial thromboplastin time (HP:0003645)2.32906803
76Cervical subluxation (HP:0003308)2.32344968
77Hand muscle atrophy (HP:0009130)2.31472402
78Progressive neurologic deterioration (HP:0002344)2.31323026
7911 pairs of ribs (HP:0000878)2.30708287
80Osteolytic defects of the hand bones (HP:0009699)2.28567693
81Osteolytic defects of the phalanges of the hand (HP:0009771)2.28567693
82Parakeratosis (HP:0001036)2.28416477
83Respiratory failure (HP:0002878)2.26579321
84Blue sclerae (HP:0000592)2.26560200
85Poor head control (HP:0002421)2.24687729
86Abnormality of renal resorption (HP:0011038)2.23673043
87Macrocytic anemia (HP:0001972)2.19991403
88Orthostatic hypotension (HP:0001278)2.19826446
89Increased cerebral lipofuscin (HP:0011813)2.19709482
90Hypobetalipoproteinemia (HP:0003563)2.17371662
91Hyperinsulinemic hypoglycemia (HP:0000825)2.17017720
92Follicular hyperkeratosis (HP:0007502)2.16944266
93Exercise intolerance (HP:0003546)2.16220913
94Abnormality of the common coagulation pathway (HP:0010990)2.15434358
95Nuclear cataract (HP:0100018)2.14024118
96Systemic lupus erythematosus (HP:0002725)2.12997848
97Loss of speech (HP:0002371)2.12837397
98Wormian bones (HP:0002645)2.12676907
99Generalized amyotrophy (HP:0003700)2.12064276
100Spinal rigidity (HP:0003306)2.10511819
101Distal lower limb muscle weakness (HP:0009053)2.09836492
102Hyperphosphaturia (HP:0003109)2.09387493
103Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09261161
104Hypertensive crisis (HP:0100735)2.08896709
105Fragile skin (HP:0001030)2.08258711
106Conjugated hyperbilirubinemia (HP:0002908)2.07740395
107Abnormal trabecular bone morphology (HP:0100671)2.07291042
108Abnormality of macrophages (HP:0004311)2.06335947
109Amyloidosis (HP:0011034)2.04976400
110Steatorrhea (HP:0002570)2.03755130
111Hypokinesia (HP:0002375)2.02002265
112Axonal loss (HP:0003447)2.01972559
113Intrahepatic cholestasis (HP:0001406)2.01488834
114Abnormality of dental color (HP:0011073)2.00601091
115Trismus (HP:0000211)2.00390563
116Pancytopenia (HP:0001876)1.99432723
117Fat malabsorption (HP:0002630)1.99256654
118Pallor (HP:0000980)1.99209015
119Increased serum ferritin (HP:0003281)1.97564033
120Lethargy (HP:0001254)1.96992545
121Abnormality of the distal phalanges of the toes (HP:0010182)1.96277602
122Short nail (HP:0001799)1.96192076
123CNS demyelination (HP:0007305)1.94874948
124Dysostosis multiplex (HP:0000943)1.94505348
125Bladder diverticulum (HP:0000015)1.92736210
126Absent eyelashes (HP:0000561)1.92496429
127Abnormality of fatty-acid metabolism (HP:0004359)1.91442469
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.90959139
129Entropion (HP:0000621)1.90937908
130Respiratory difficulties (HP:0002880)1.90650713
131Biconcave vertebral bodies (HP:0004586)1.89377931
132Ragged-red muscle fibers (HP:0003200)1.89070471
133Vertebral compression fractures (HP:0002953)1.87506260
134Abnormality of pyrimidine metabolism (HP:0004353)1.86759698
135Hyperbilirubinemia (HP:0002904)1.86163971
136Aortic dissection (HP:0002647)1.85921959
137Glucose intolerance (HP:0000833)1.85912527
138Testicular atrophy (HP:0000029)1.84732307
139Purpura (HP:0000979)1.84248969
140Ketosis (HP:0001946)1.83344489
141Esophageal neoplasm (HP:0100751)1.83044593
142Neoplasm of head and neck (HP:0012288)1.83044593
143Late onset (HP:0003584)1.82523198
144Methylmalonic aciduria (HP:0012120)1.81590945
145Oral leukoplakia (HP:0002745)1.81290628
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80373484
147Abnormality of the acetabulum (HP:0003170)1.78943291
148Petechiae (HP:0000967)1.78818628
149Irregular epiphyses (HP:0010582)1.78774203
150Cerebral hypomyelination (HP:0006808)1.77615353
151Microretrognathia (HP:0000308)1.77606107
152Irregular vertebral endplates (HP:0003301)1.77362737
153Increased serum pyruvate (HP:0003542)1.76949855
154Abnormal pupillary function (HP:0007686)1.76744061
155Myocardial infarction (HP:0001658)1.76718092
156Spondylolisthesis (HP:0003302)1.76402250
157Redundant skin (HP:0001582)1.75902526
158Premature skin wrinkling (HP:0100678)1.74774055
159Abnormality of glycolysis (HP:0004366)1.74547567
160Increased connective tissue (HP:0009025)1.73510503
161Peritonitis (HP:0002586)1.71325908
162Soft skin (HP:0000977)1.71238543
163Sparse eyelashes (HP:0000653)1.70504146
164Abnormal autonomic nervous system physiology (HP:0012332)1.70503896
165Ketoacidosis (HP:0001993)1.69185518
166Megaloblastic anemia (HP:0001889)1.69102336
167Elevated erythrocyte sedimentation rate (HP:0003565)1.68962794
168Fasciculations (HP:0002380)1.68903535
169Abnormal tarsal ossification (HP:0008369)1.66362802
170Rough bone trabeculation (HP:0100670)1.65702437
171Abnormal urine phosphate concentration (HP:0012599)1.64610054
172Secondary amenorrhea (HP:0000869)1.63538501
173Abnormality of T cell physiology (HP:0011840)1.61419072
174Epiphyseal stippling (HP:0010655)1.61364407
175Aplasia/hypoplasia of the uterus (HP:0008684)1.61317224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.96789712
2STK163.77033181
3EIF2AK33.38005112
4VRK23.23838905
5BCKDK3.10398011
6BUB12.83642639
7ERN12.72691197
8EIF2AK12.67308393
9PIM22.66214012
10TAOK32.32856631
11TESK22.31044566
12IRAK32.21317021
13TLK12.18938304
14PASK2.08787528
15KDR1.94143552
16VRK11.91971374
17IRAK41.87120923
18FLT31.85892911
19WEE11.79942217
20PIK3CG1.77681809
21MST1R1.72233567
22TESK11.65991271
23BRSK21.60318854
24MAP3K31.51703373
25SIK31.47228425
26MOS1.46376177
27TEC1.40971048
28BMPR1B1.38565397
29SMG11.38206556
30MAPK151.37930517
31TGFBR21.33474187
32PBK1.31847391
33CDK81.26883609
34MAP3K111.25487781
35MAPKAPK31.25176489
36RPS6KA41.22743642
37LMTK21.20197480
38NME11.16053039
39SIK11.15599533
40SCYL21.14845023
41TNIK1.12394361
42MAP3K121.12266987
43EPHA21.10507033
44BLK1.08046215
45PTK21.05354145
46SRPK11.02911676
47TBK11.01909631
48GRK71.01881414
49BRAF1.00356009
50DAPK10.98580419
51KIT0.98060754
52ACVR1B0.97960843
53ZAP700.97061072
54EPHB20.93703086
55DDR20.93333512
56DAPK30.92393438
57ABL20.92371141
58LIMK10.89961613
59CAMKK20.89907546
60MAP2K20.88940310
61TYK20.88543954
62BTK0.87678351
63FRK0.85413523
64EIF2AK20.84611912
65STK100.84348236
66PLK40.79608997
67TRIB30.79339622
68NEK10.77908067
69ZAK0.76696817
70CDK70.76218933
71NEK90.75879414
72NTRK10.75409447
73TGFBR10.73943324
74PDK20.73316530
75INSRR0.72814674
76MAP3K140.72388931
77MST40.72167035
78ADRBK20.71351706
79PAK40.70929247
80ERBB40.70366802
81TTN0.69224743
82MAPKAPK50.68768300
83IRAK10.67702386
84MYLK0.66698115
85PDGFRA0.65739512
86ICK0.64700532
87CSNK1G30.62288801
88TSSK60.61670291
89CSNK2A10.61608445
90ARAF0.61560361
91MKNK10.61295713
92PRPF4B0.60849443
93MAP4K10.60466783
94LRRK20.58898434
95IKBKB0.58197510
96CCNB10.57997763
97LYN0.56843715
98RIPK10.56166336
99ILK0.55819056
100MAP2K30.54125397
101BRSK10.53360374
102DYRK30.53293645
103CDC70.52690140
104AURKA0.51691831
105PAK20.51500833
106RPS6KB20.51239312
107AURKB0.50633540
108JAK30.49884002
109TAOK20.49370136
110PRKG20.49118047
111RPS6KA50.48782640
112CSNK2A20.46783708
113ATR0.43817050
114PLK10.43293805
115NLK0.43013528
116IKBKE0.41794591
117TXK0.41446635
118CSNK1A1L0.41310704
119EPHB10.40527412
120WNK40.39350695
121MAPKAPK20.38606885
122MAP3K10.37348245
123MAPK110.37239686
124CAMK2G0.35905107
125CLK10.35448652
126MATK0.34816962
127PRKD20.34460045
128CDK140.34148581
129CDK11A0.33759697
130RAF10.33472744
131PAK10.32842451
132MAP3K80.32607175
133NUAK10.32377303
134MKNK20.32257084
135PIM10.32069650
136MET0.31744906
137MARK30.30738001
138PRKCI0.30402078
139CDK150.30147038
140BMX0.28702247
141CDK180.27748276
142GSK3A0.27356021
143GRK50.24651913
144PTK60.22303837
145MAP3K130.19973544

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.15632679
2Ribosome_Homo sapiens_hsa030103.37662894
3Proteasome_Homo sapiens_hsa030503.19363804
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.68447041
5DNA replication_Homo sapiens_hsa030302.67346721
6Folate biosynthesis_Homo sapiens_hsa007902.34874939
7Oxidative phosphorylation_Homo sapiens_hsa001902.34355144
8Sulfur metabolism_Homo sapiens_hsa009202.12055900
9N-Glycan biosynthesis_Homo sapiens_hsa005101.97946808
10RNA polymerase_Homo sapiens_hsa030201.95002546
11Parkinsons disease_Homo sapiens_hsa050121.94112420
12Pyrimidine metabolism_Homo sapiens_hsa002401.93964160
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89923655
14Mismatch repair_Homo sapiens_hsa034301.85573737
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85363398
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71041166
17Sulfur relay system_Homo sapiens_hsa041221.65247927
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62734235
19Homologous recombination_Homo sapiens_hsa034401.61892344
20One carbon pool by folate_Homo sapiens_hsa006701.59844894
21Rheumatoid arthritis_Homo sapiens_hsa053231.59052621
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57742618
23Other glycan degradation_Homo sapiens_hsa005111.53640106
24Base excision repair_Homo sapiens_hsa034101.51519794
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43606425
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42641652
27Salmonella infection_Homo sapiens_hsa051321.42411564
28Shigellosis_Homo sapiens_hsa051311.40321449
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36202200
30Nucleotide excision repair_Homo sapiens_hsa034201.35165430
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.34757376
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30096392
33Huntingtons disease_Homo sapiens_hsa050161.29446687
34Fatty acid elongation_Homo sapiens_hsa000621.27602376
35Alzheimers disease_Homo sapiens_hsa050101.24351989
36Steroid biosynthesis_Homo sapiens_hsa001001.20451159
37Selenocompound metabolism_Homo sapiens_hsa004501.19375490
38Bladder cancer_Homo sapiens_hsa052191.17597538
39Glutathione metabolism_Homo sapiens_hsa004801.17403159
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16352199
41Spliceosome_Homo sapiens_hsa030401.14808290
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11049754
43Allograft rejection_Homo sapiens_hsa053301.08471932
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08438324
45Histidine metabolism_Homo sapiens_hsa003401.08148598
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06794332
47Peroxisome_Homo sapiens_hsa041461.05970872
48Prion diseases_Homo sapiens_hsa050201.05788386
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04653977
50Galactose metabolism_Homo sapiens_hsa000521.03656064
51Arginine and proline metabolism_Homo sapiens_hsa003301.01459990
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01237948
53Autoimmune thyroid disease_Homo sapiens_hsa053201.00224188
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99595670
55Graft-versus-host disease_Homo sapiens_hsa053320.98234903
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96985366
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95976113
58Pentose phosphate pathway_Homo sapiens_hsa000300.93927731
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.89948527
60Purine metabolism_Homo sapiens_hsa002300.89640607
61Metabolic pathways_Homo sapiens_hsa011000.89518151
62Vibrio cholerae infection_Homo sapiens_hsa051100.89218026
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87688116
64Pertussis_Homo sapiens_hsa051330.86999552
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85689159
66Asthma_Homo sapiens_hsa053100.83527938
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.83457798
68Viral myocarditis_Homo sapiens_hsa054160.81715395
69Apoptosis_Homo sapiens_hsa042100.81212372
70Tryptophan metabolism_Homo sapiens_hsa003800.80838993
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80473035
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79720816
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.78188734
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75699474
75Arachidonic acid metabolism_Homo sapiens_hsa005900.75537516
76Non-homologous end-joining_Homo sapiens_hsa034500.73804469
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73518923
78Legionellosis_Homo sapiens_hsa051340.73417668
79Fat digestion and absorption_Homo sapiens_hsa049750.72206633
80Lysosome_Homo sapiens_hsa041420.71774279
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71551286
82Primary immunodeficiency_Homo sapiens_hsa053400.70669619
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70376673
84Chemical carcinogenesis_Homo sapiens_hsa052040.69889063
85Hematopoietic cell lineage_Homo sapiens_hsa046400.69571812
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.69520192
87Malaria_Homo sapiens_hsa051440.69309454
88Fatty acid degradation_Homo sapiens_hsa000710.68399166
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68340307
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67330719
91Epstein-Barr virus infection_Homo sapiens_hsa051690.66708763
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64747637
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.64554581
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64182240
95Caffeine metabolism_Homo sapiens_hsa002320.64131032
96Pyruvate metabolism_Homo sapiens_hsa006200.62854022
97Biosynthesis of amino acids_Homo sapiens_hsa012300.62694155
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62173172
99Carbon metabolism_Homo sapiens_hsa012000.61294622
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60791092
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.59485994
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.58389864
103Type I diabetes mellitus_Homo sapiens_hsa049400.58323159
104Basal transcription factors_Homo sapiens_hsa030220.57464615
105Antigen processing and presentation_Homo sapiens_hsa046120.57316980
106Fructose and mannose metabolism_Homo sapiens_hsa000510.56603855
107Linoleic acid metabolism_Homo sapiens_hsa005910.55489297
108Tyrosine metabolism_Homo sapiens_hsa003500.55409997
109Sphingolipid metabolism_Homo sapiens_hsa006000.54613055
110RNA transport_Homo sapiens_hsa030130.54521330
111Phenylalanine metabolism_Homo sapiens_hsa003600.54438565
112Propanoate metabolism_Homo sapiens_hsa006400.54344578
113Starch and sucrose metabolism_Homo sapiens_hsa005000.53508064
114TNF signaling pathway_Homo sapiens_hsa046680.53408175
115Fanconi anemia pathway_Homo sapiens_hsa034600.53338619
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51649787
117Vitamin digestion and absorption_Homo sapiens_hsa049770.51510405
118Renin-angiotensin system_Homo sapiens_hsa046140.51023896
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50473449
120ECM-receptor interaction_Homo sapiens_hsa045120.49618955
121beta-Alanine metabolism_Homo sapiens_hsa004100.49539135
122Leishmaniasis_Homo sapiens_hsa051400.48872954
123Complement and coagulation cascades_Homo sapiens_hsa046100.48569363
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47791570
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.47054273
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46575008
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45866651
128Herpes simplex infection_Homo sapiens_hsa051680.45618620
129Staphylococcus aureus infection_Homo sapiens_hsa051500.45202331
130Tuberculosis_Homo sapiens_hsa051520.45088659
131RNA degradation_Homo sapiens_hsa030180.44981024
132Collecting duct acid secretion_Homo sapiens_hsa049660.44433028
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44178524
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41539779
135Phagosome_Homo sapiens_hsa041450.41502843
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39781686
137Systemic lupus erythematosus_Homo sapiens_hsa053220.38885393
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38489083
139Retinol metabolism_Homo sapiens_hsa008300.38272305

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