MYEOV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.57546927
2establishment of integrated proviral latency (GO:0075713)4.93298378
3COPI coating of Golgi vesicle (GO:0048205)4.78405176
4Golgi transport vesicle coating (GO:0048200)4.78405176
5establishment of viral latency (GO:0019043)4.54148359
6positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.32474813
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.30075681
8DNA unwinding involved in DNA replication (GO:0006268)4.20735637
9mitotic nuclear envelope reassembly (GO:0007084)4.19850324
10nuclear envelope reassembly (GO:0031468)4.19850324
11mesodermal cell differentiation (GO:0048333)3.86724620
12mitotic chromosome condensation (GO:0007076)3.84697835
13membrane raft organization (GO:0031579)3.78403291
14regulation of metalloenzyme activity (GO:0048552)3.77752785
15desmosome organization (GO:0002934)3.70501488
16negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.67675832
17proteasome assembly (GO:0043248)3.61451288
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61267873
19negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.56385068
20hemidesmosome assembly (GO:0031581)3.56095545
21ribosome assembly (GO:0042255)3.54083722
22muscle cell migration (GO:0014812)3.52923671
23nucleobase-containing small molecule interconversion (GO:0015949)3.43204104
24positive regulation of DNA-dependent DNA replication (GO:2000105)3.35232150
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32469436
26regulation of translational termination (GO:0006449)3.29311644
27mitotic sister chromatid segregation (GO:0000070)3.29252657
28regulation of mitotic spindle organization (GO:0060236)3.26829402
29skin morphogenesis (GO:0043589)3.25109550
30protein retention in ER lumen (GO:0006621)3.18497107
31response to gravity (GO:0009629)3.17066111
32activation of Rac GTPase activity (GO:0032863)3.16290739
33proline biosynthetic process (GO:0006561)3.15428372
34protein localization to endosome (GO:0036010)3.09353522
35barbed-end actin filament capping (GO:0051016)3.06727861
36mitotic metaphase plate congression (GO:0007080)3.05611518
37positive regulation of actin filament depolymerization (GO:0030836)3.04133770
38extracellular fibril organization (GO:0043206)3.03589517
39glucose catabolic process (GO:0006007)3.01326944
40regulation of spindle organization (GO:0090224)3.00121432
41mitochondrial calcium ion transport (GO:0006851)2.99963969
42formation of translation preinitiation complex (GO:0001731)2.99629793
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93163229
44positive regulation of pseudopodium assembly (GO:0031274)2.92333881
45telomere maintenance via semi-conservative replication (GO:0032201)2.91277639
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90226267
47hepatocyte apoptotic process (GO:0097284)2.89016086
48tRNA methylation (GO:0030488)2.88527907
49hypotonic response (GO:0006971)2.87639335
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84725415
51pentose-phosphate shunt (GO:0006098)2.83927429
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80089519
53pyrimidine nucleoside salvage (GO:0043097)2.77562652
54pyrimidine-containing compound salvage (GO:0008655)2.77562652
55sister chromatid segregation (GO:0000819)2.74952951
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74469340
57negative regulation of ligase activity (GO:0051352)2.74469340
58DNA strand elongation involved in DNA replication (GO:0006271)2.74274061
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73491482
60DNA strand elongation (GO:0022616)2.70859332
61regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67555201
62nucleoside salvage (GO:0043174)2.65959344
63epithelial cell-cell adhesion (GO:0090136)2.64415373
64protein autoprocessing (GO:0016540)2.63601108
65heterochromatin organization (GO:0070828)2.63345148
66de novo protein folding (GO:0006458)2.63208477
67retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61091151
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61063675
69cellular copper ion homeostasis (GO:0006878)2.60456033
70regulation of cellular amino acid metabolic process (GO:0006521)2.60013107
71mammary gland epithelial cell proliferation (GO:0033598)2.57895269
72regulation of translational fidelity (GO:0006450)2.57173974
73cell adhesion mediated by integrin (GO:0033627)2.53396479
74actin filament depolymerization (GO:0030042)2.51425680
75fibril organization (GO:0097435)2.50772408
76lung vasculature development (GO:0060426)2.50333305
77virion assembly (GO:0019068)2.49786662
78regulation of pseudopodium assembly (GO:0031272)2.49720426
79mitochondrial calcium ion homeostasis (GO:0051560)2.49292450
80deoxyribonucleotide biosynthetic process (GO:0009263)2.48514001
81positive regulation of ligase activity (GO:0051351)2.48049752
82cellular response to virus (GO:0098586)2.47710745
83platelet aggregation (GO:0070527)2.45978374
84positive regulation of Rho protein signal transduction (GO:0035025)2.45415747
85protein hydroxylation (GO:0018126)2.44101107
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.43829217
87positive regulation of macrophage differentiation (GO:0045651)2.43468457
88de novo posttranslational protein folding (GO:0051084)2.41514111
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40326351
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40116252
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40116252
92metaphase plate congression (GO:0051310)2.38898378
93SMAD protein complex assembly (GO:0007183)2.38814693
94ribosome biogenesis (GO:0042254)2.37743067
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.36486422
96signal transduction involved in DNA damage checkpoint (GO:0072422)2.36486422
97deoxyribose phosphate biosynthetic process (GO:0046385)2.35183521
982-deoxyribonucleotide biosynthetic process (GO:0009265)2.35183521
99cell-substrate junction assembly (GO:0007044)2.34818720
100NADPH regeneration (GO:0006740)2.34488565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.56552259
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.37832693
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30518433
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22002093
5ZNF263_19887448_ChIP-Seq_K562_Human2.98210790
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92506758
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.62864155
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61103011
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55648714
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51961497
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46459830
12DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.41497633
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38521388
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.24937521
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00870661
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99186669
17* ELK3_25401928_ChIP-Seq_HUVEC_Human1.98123990
18ATF3_27146783_Chip-Seq_COLON_Human1.97549977
19DCP1A_22483619_ChIP-Seq_HELA_Human1.96769507
20HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.93346352
21* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92527277
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90351096
23* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.87761096
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82519868
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82519868
26AR_21909140_ChIP-Seq_LNCAP_Human1.81958021
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75262041
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70522933
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69558142
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69108408
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67494918
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66909833
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63271191
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60458996
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60447012
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54338233
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52860603
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52301603
39RACK7_27058665_Chip-Seq_MCF-7_Human1.50627902
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50477122
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49494756
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48413882
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47659795
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.47326874
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46283818
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44183262
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43930223
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39384275
49XRN2_22483619_ChIP-Seq_HELA_Human1.38617542
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37850191
51GABP_19822575_ChIP-Seq_HepG2_Human1.36071038
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33940626
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.31348898
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31321393
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31149208
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30285513
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28542716
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27827047
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26556490
60* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25490945
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24019798
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23689112
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20648162
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20506640
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19757583
66CLOCK_20551151_ChIP-Seq_293T_Human1.19191799
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.19164751
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18895203
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16199037
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.15136097
71* NCOR1_26117541_ChIP-Seq_K562_Human1.14720985
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14308588
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13590582
74TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12710373
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12230688
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11715623
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11285943
78LXR_22292898_ChIP-Seq_THP-1_Human1.09212109
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08983458
80TFEB_21752829_ChIP-Seq_HELA_Human1.08365191
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.08173290
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07469404
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07233368
84KDM5A_27292631_Chip-Seq_BREAST_Human1.06963354
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06773791
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06598555
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06588504
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.03234060
89* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02944032
90GATA6_25053715_ChIP-Seq_YYC3_Human1.02499025
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02001533
92MYC_22102868_ChIP-Seq_BL_Human1.00857584
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00802260
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00684857
95* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99559885
96TTF2_22483619_ChIP-Seq_HELA_Human0.99300738
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.96982461
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96894314
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96273198
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.95907262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.86066107
2MP0003950_abnormal_plasma_membrane3.35721650
3MP0010234_abnormal_vibrissa_follicle3.22084543
4MP0003566_abnormal_cell_adhesion3.06702796
5MP0005464_abnormal_platelet_physiology2.87453719
6MP0003191_abnormal_cellular_cholesterol2.79312428
7MP0005451_abnormal_body_composition2.27061929
8MP0005501_abnormal_skin_physiology2.26391404
9MP0004185_abnormal_adipocyte_glucose2.25845030
10MP0003806_abnormal_nucleotide_metabolis2.25127390
11MP0009697_abnormal_copulation2.20060039
12MP0004957_abnormal_blastocyst_morpholog2.17811471
13MP0000858_altered_metastatic_potential2.13939402
14MP0005257_abnormal_intraocular_pressure2.06147175
15MP0009780_abnormal_chondrocyte_physiolo2.05897828
16MP0003453_abnormal_keratinocyte_physiol2.02356806
17MP0002796_impaired_skin_barrier2.01783769
18MP0004510_myositis1.92306285
19MP0004272_abnormal_basement_membrane1.88032823
20MP0005083_abnormal_biliary_tract1.87503911
21MP0008932_abnormal_embryonic_tissue1.86907261
22MP0003111_abnormal_nucleus_morphology1.83567264
23MP0003705_abnormal_hypodermis_morpholog1.82490445
24MP0003693_abnormal_embryo_hatching1.72108255
25MP0005023_abnormal_wound_healing1.68968878
26MP0003077_abnormal_cell_cycle1.68153011
27MP0005165_increased_susceptibility_to1.64844075
28MP0005670_abnormal_white_adipose1.60256760
29MP0000751_myopathy1.55071305
30MP0001216_abnormal_epidermal_layer1.53211708
31MP0002332_abnormal_exercise_endurance1.53019633
32MP0010352_gastrointestinal_tract_polyps1.52594449
33MP0009053_abnormal_anal_canal1.51896947
34MP0010094_abnormal_chromosome_stability1.51692175
35MP0000343_altered_response_to1.49803511
36MP0000750_abnormal_muscle_regeneration1.47817670
37MP0008007_abnormal_cellular_replicative1.46475126
38MP0002060_abnormal_skin_morphology1.44593183
39MP0000537_abnormal_urethra_morphology1.41312740
40MP0005666_abnormal_adipose_tissue1.40921735
41MP0010030_abnormal_orbit_morphology1.39855287
42MP0000762_abnormal_tongue_morphology1.31067120
43MP0000358_abnormal_cell_content/1.30465812
44MP0000749_muscle_degeneration1.28367702
45MP0005058_abnormal_lysosome_morphology1.27717260
46MP0004947_skin_inflammation1.26713426
47MP0001730_embryonic_growth_arrest1.24722462
48MP0004233_abnormal_muscle_weight1.23354195
49MP0003123_paternal_imprinting1.22936578
50MP0000350_abnormal_cell_proliferation1.21071884
51MP0008058_abnormal_DNA_repair1.19212642
52MP0003786_premature_aging1.19176370
53MP0005076_abnormal_cell_differentiation1.18859018
54MP0001853_heart_inflammation1.17745768
55MP0003315_abnormal_perineum_morphology1.15285033
56MP0009840_abnormal_foam_cell1.15240048
57MP0003091_abnormal_cell_migration1.14768443
58MP0010771_integument_phenotype1.12021238
59MP0000003_abnormal_adipose_tissue1.09855505
60MP0003656_abnormal_erythrocyte_physiolo1.09517426
61MP0003718_maternal_effect1.09148302
62MP0002080_prenatal_lethality1.09113093
63MP0005330_cardiomyopathy1.08463305
64MP0003186_abnormal_redox_activity1.07817135
65MP0005375_adipose_tissue_phenotype1.06827457
66MP0001849_ear_inflammation1.03284322
67MP0005164_abnormal_response_to1.01613452
68MP0001697_abnormal_embryo_size0.96271013
69MP0008775_abnormal_heart_ventricle0.94724298
70MP0002019_abnormal_tumor_incidence0.93873588
71MP0001881_abnormal_mammary_gland0.93856512
72MP0000647_abnormal_sebaceous_gland0.93809095
73MP0005621_abnormal_cell_physiology0.92853965
74MP0000678_abnormal_parathyroid_gland0.88280276
75MP0000627_abnormal_mammary_gland0.88250000
76MP0006036_abnormal_mitochondrial_physio0.87425315
77MP0002970_abnormal_white_adipose0.87078177
78MP0002086_abnormal_extraembryonic_tissu0.86331311
79MP0003075_altered_response_to0.84840745
80MP0004808_abnormal_hematopoietic_stem0.83794276
81MP0005384_cellular_phenotype0.80441332
82MP0009931_abnormal_skin_appearance0.79884848
83MP0000313_abnormal_cell_death0.79675334
84MP0000490_abnormal_crypts_of0.78984849
85MP0010678_abnormal_skin_adnexa0.78721096
86MP0001873_stomach_inflammation0.78129411
87MP0005197_abnormal_uvea_morphology0.77683483
88MP0004264_abnormal_extraembryonic_tissu0.76986682
89MP0009333_abnormal_splenocyte_physiolog0.76767134
90MP0001243_abnormal_dermal_layer0.75542286
91MP0001672_abnormal_embryogenesis/_devel0.75429968
92MP0005380_embryogenesis_phenotype0.75429968
93MP0000613_abnormal_salivary_gland0.75035708
94MP0000467_abnormal_esophagus_morphology0.74729918
95MP0003828_pulmonary_edema0.74633387
96MP0008260_abnormal_autophagy0.74112681
97MP0002972_abnormal_cardiac_muscle0.73656180
98MP0004084_abnormal_cardiac_muscle0.72616771
99MP0006035_abnormal_mitochondrial_morpho0.71400450
100MP0003984_embryonic_growth_retardation0.70558528

Predicted human phenotypes

RankGene SetZ-score
1Distal lower limb amyotrophy (HP:0008944)4.39494711
2Upper limb muscle weakness (HP:0003484)4.18473710
3Reduced subcutaneous adipose tissue (HP:0003758)3.97129451
4Menorrhagia (HP:0000132)3.96719555
5Increased mean platelet volume (HP:0011877)3.72268078
6Osteolytic defects of the phalanges of the hand (HP:0009771)3.50771485
7Osteolytic defects of the hand bones (HP:0009699)3.50771485
8Short nail (HP:0001799)3.48270986
9Distal lower limb muscle weakness (HP:0009053)3.25761148
10Abnormality of the distal phalanges of the toes (HP:0010182)3.22292992
11Abnormal platelet volume (HP:0011876)3.21879787
12Increased connective tissue (HP:0009025)3.05891005
13Trismus (HP:0000211)3.01866481
14Entropion (HP:0000621)2.99873487
15Impaired platelet aggregation (HP:0003540)2.98589057
16Abnormal platelet function (HP:0011869)2.98589057
17Glucose intolerance (HP:0000833)2.95048219
18Onycholysis (HP:0001806)2.93496127
19Nail dystrophy (HP:0008404)2.92956960
20Broad face (HP:0000283)2.88903892
21Lower limb amyotrophy (HP:0007210)2.87645376
22Insulin resistance (HP:0000855)2.86611244
23Rough bone trabeculation (HP:0100670)2.83312603
24Distal upper limb amyotrophy (HP:0007149)2.75580266
25Upper limb amyotrophy (HP:0009129)2.75580266
26Abnormal gallbladder physiology (HP:0012438)2.74711759
27Cholecystitis (HP:0001082)2.74711759
28Deviation of the thumb (HP:0009603)2.72908007
29Premature rupture of membranes (HP:0001788)2.67790058
30Hyperacusis (HP:0010780)2.65000547
31Sparse eyelashes (HP:0000653)2.64206768
32Petechiae (HP:0000967)2.64179772
33Achilles tendon contracture (HP:0001771)2.60485572
34Proximal placement of thumb (HP:0009623)2.55538053
35Abnormality of the Achilles tendon (HP:0005109)2.54273586
36Vascular calcification (HP:0004934)2.53941334
37Acanthosis nigricans (HP:0000956)2.53215168
38Tongue fasciculations (HP:0001308)2.50687365
39Difficulty climbing stairs (HP:0003551)2.49483660
40Glomerulosclerosis (HP:0000096)2.48018378
41Myocardial infarction (HP:0001658)2.47378222
42Focal segmental glomerulosclerosis (HP:0000097)2.46907057
43Selective tooth agenesis (HP:0001592)2.41702497
44Vertebral compression fractures (HP:0002953)2.40270181
45Insomnia (HP:0100785)2.38608646
46Abnormality of oral frenula (HP:0000190)2.34077138
47Progressive muscle weakness (HP:0003323)2.31716473
48Axonal loss (HP:0003447)2.30627173
49Adrenal hypoplasia (HP:0000835)2.29597132
50Hypokinesia (HP:0002375)2.28823027
51Hypertriglyceridemia (HP:0002155)2.24854554
52Poikiloderma (HP:0001029)2.21116850
53Ankyloglossia (HP:0010296)2.20798526
54Abnormality of the umbilical cord (HP:0010881)2.17963209
55Hypertensive crisis (HP:0100735)2.14430372
56Orthostatic hypotension (HP:0001278)2.12493068
57Cardiovascular calcification (HP:0011915)2.11887349
58Prolonged bleeding time (HP:0003010)2.11014549
59Male infertility (HP:0003251)2.10592632
60Unilateral renal agenesis (HP:0000122)2.08050687
61Fasciculations (HP:0002380)2.07797297
62Muscle fibrillation (HP:0010546)2.06200018
63Progressive hearing impairment (HP:0001730)2.05111679
64Decreased subcutaneous fat (HP:0001002)2.02788303
65Abnormal trabecular bone morphology (HP:0100671)2.02082737
66Conjugated hyperbilirubinemia (HP:0002908)2.00933594
67Fatigue (HP:0012378)1.98653387
68Milia (HP:0001056)1.96245078
69Alopecia of scalp (HP:0002293)1.95724303
70Ileus (HP:0002595)1.94729350
71Atrophic scars (HP:0001075)1.94726638
72Hand muscle atrophy (HP:0009130)1.94524655
73Abnormality of glycolysis (HP:0004366)1.94343037
74Hepatosplenomegaly (HP:0001433)1.93983299
75Spinal rigidity (HP:0003306)1.93796009
76Abnormal pupillary function (HP:0007686)1.93595198
77Fragile nails (HP:0001808)1.91771792
78Right ventricular cardiomyopathy (HP:0011663)1.90714349
79Pili torti (HP:0003777)1.89359766
80Dysautonomia (HP:0002459)1.88758842
81Abnormal autonomic nervous system physiology (HP:0012332)1.88029171
82Generalized amyotrophy (HP:0003700)1.87371556
83Interstitial pulmonary disease (HP:0006530)1.87276604
84Thick nail (HP:0001805)1.86299679
85Limb-girdle muscle atrophy (HP:0003797)1.85165134
86Abnormalities of placenta or umbilical cord (HP:0001194)1.85120688
87Micronodular cirrhosis (HP:0001413)1.82576161
88Brittle hair (HP:0002299)1.81723155
89Shoulder girdle muscle weakness (HP:0003547)1.80148623
90Ureteral duplication (HP:0000073)1.77504269
91Microglossia (HP:0000171)1.77456387
92Epistaxis (HP:0000421)1.77312560
93Abnormal glucose tolerance (HP:0001952)1.77038400
94Pelvic girdle muscle weakness (HP:0003749)1.76850586
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75896018
96Congenital ichthyosiform erythroderma (HP:0007431)1.75577930
97Fragile skin (HP:0001030)1.73643408
98Increased serum pyruvate (HP:0003542)1.73380636
99Growth hormone excess (HP:0000845)1.72376815
100Abnormal auditory evoked potentials (HP:0006958)1.72181060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.30840551
2MST1R5.38030640
3IRAK33.70643496
4NME23.65495016
5BUB12.95379189
6TESK12.91689750
7MET2.63012717
8MST42.62968883
9TESK22.52225085
10VRK22.37340620
11LIMK12.17950262
12PTK22.14279511
13EIF2AK12.10502524
14PAK42.10493423
15LMTK21.95967069
16ARAF1.84135141
17BMX1.63932818
18CDK81.62664481
19ERN11.60320248
20MAP3K121.60165280
21ERBB41.56296873
22ICK1.54388831
23STK101.51385443
24EPHB21.32209747
25SIK11.32138363
26EPHB11.31448797
27NEK11.25408730
28ILK1.21553032
29TTN1.21190376
30PIM21.20130012
31SIK31.19148063
32SCYL21.17213437
33TAOK21.15929281
34DAPK11.10948401
35PBK1.09595594
36ABL21.01310203
37MYLK1.01229017
38SMG10.98744073
39MAP3K30.94540451
40BRSK10.92239491
41MAP3K80.90466398
42PRKCI0.84039047
43LATS20.82494641
44PTK2B0.79140496
45LATS10.78970138
46AURKA0.78248958
47SRPK10.77458860
48PAK10.76688575
49BMPR20.74454523
50MAP2K30.66072743
51TSSK60.65526594
52BRAF0.65281364
53CCNB10.64837024
54NEK20.64118404
55MOS0.62489975
56AURKB0.61029981
57MAP2K70.60760633
58MAPKAPK30.56360989
59CDK70.56018479
60LRRK20.54375607
61NTRK10.52414323
62STK30.50980643
63RAF10.50296035
64PRKG20.49697015
65STK380.47878593
66WEE10.46814668
67TTK0.44951976
68TRIB30.44662803
69PTK60.44343862
70RPS6KA40.43612465
71TRIM280.42823964
72PLK10.39817464
73CAMK2G0.37871081
74MAPKAPK20.37843534
75MAP3K20.37785545
76CHEK20.37502520
77MAP3K60.36987078
78IRAK20.36077107
79STK160.35655763
80PHKG10.33465207
81PHKG20.33465207
82NME10.32793655
83CDK90.32723597
84KDR0.32341776
85KSR10.31251514
86RPS6KB20.29948716
87EIF2AK20.29776481
88DMPK0.28031451
89STK40.27880475
90PDGFRA0.27864853
91MAP3K10.26902326
92MELK0.25934281
93MAP3K110.25716114
94MTOR0.25371206
95DAPK30.25300153
96MATK0.24181044
97GSK3A0.24099743
98PLK30.23524848
99HIPK20.23276011
100CDK120.22947690

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.99383526
2DNA replication_Homo sapiens_hsa030303.29528187
3Mismatch repair_Homo sapiens_hsa034302.61310076
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.57693630
5Sulfur relay system_Homo sapiens_hsa041222.38791274
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.29867126
7Pyrimidine metabolism_Homo sapiens_hsa002402.23815051
8Pentose phosphate pathway_Homo sapiens_hsa000302.16529287
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15870168
10Base excision repair_Homo sapiens_hsa034102.10392987
11Nucleotide excision repair_Homo sapiens_hsa034202.06057435
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99940092
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93109159
14Shigellosis_Homo sapiens_hsa051311.82894752
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80605247
16Galactose metabolism_Homo sapiens_hsa000521.75911418
17Biosynthesis of amino acids_Homo sapiens_hsa012301.75542533
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.74272527
19Bladder cancer_Homo sapiens_hsa052191.72382857
20Cell cycle_Homo sapiens_hsa041101.65145135
21Thyroid cancer_Homo sapiens_hsa052161.59812396
22Glutathione metabolism_Homo sapiens_hsa004801.59727614
23Fructose and mannose metabolism_Homo sapiens_hsa000511.59166458
24Fatty acid elongation_Homo sapiens_hsa000621.57577762
25Pancreatic cancer_Homo sapiens_hsa052121.52609454
26N-Glycan biosynthesis_Homo sapiens_hsa005101.48502023
27Folate biosynthesis_Homo sapiens_hsa007901.40590099
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37409348
29RNA polymerase_Homo sapiens_hsa030201.34404504
30Adherens junction_Homo sapiens_hsa045201.33715660
31Homologous recombination_Homo sapiens_hsa034401.32722180
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29424343
33Chronic myeloid leukemia_Homo sapiens_hsa052201.27541824
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26578426
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.21637622
36RNA transport_Homo sapiens_hsa030131.20685218
37Apoptosis_Homo sapiens_hsa042101.20649016
38Vibrio cholerae infection_Homo sapiens_hsa051101.18891982
39Small cell lung cancer_Homo sapiens_hsa052221.17613054
40Carbon metabolism_Homo sapiens_hsa012001.17115765
41Focal adhesion_Homo sapiens_hsa045101.13259439
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09533925
43Spliceosome_Homo sapiens_hsa030401.06420961
44Endocytosis_Homo sapiens_hsa041441.01161056
45Salmonella infection_Homo sapiens_hsa051320.96382737
46Proteoglycans in cancer_Homo sapiens_hsa052050.96155436
47Pyruvate metabolism_Homo sapiens_hsa006200.95746153
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.93076862
49Sulfur metabolism_Homo sapiens_hsa009200.92336023
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91912778
51Phenylalanine metabolism_Homo sapiens_hsa003600.81576806
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80886542
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80567818
54ECM-receptor interaction_Homo sapiens_hsa045120.80326760
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80196883
56Viral carcinogenesis_Homo sapiens_hsa052030.79633977
57Purine metabolism_Homo sapiens_hsa002300.77427861
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.76028829
59One carbon pool by folate_Homo sapiens_hsa006700.75586608
60p53 signaling pathway_Homo sapiens_hsa041150.72609269
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68254108
62Ribosome_Homo sapiens_hsa030100.68014583
63Hippo signaling pathway_Homo sapiens_hsa043900.67336970
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.66046891
65Non-small cell lung cancer_Homo sapiens_hsa052230.64162751
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62800236
67Huntingtons disease_Homo sapiens_hsa050160.60452537
68Epstein-Barr virus infection_Homo sapiens_hsa051690.58563639
69Renal cell carcinoma_Homo sapiens_hsa052110.56352060
70Platelet activation_Homo sapiens_hsa046110.54818292
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53891125
72Non-homologous end-joining_Homo sapiens_hsa034500.49759340
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47433279
74Tight junction_Homo sapiens_hsa045300.46433991
75Tyrosine metabolism_Homo sapiens_hsa003500.46409722
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46009584
77HTLV-I infection_Homo sapiens_hsa051660.44413016
78Basal transcription factors_Homo sapiens_hsa030220.43578291
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43131600
80Endometrial cancer_Homo sapiens_hsa052130.42603031
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42099526
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41953288
83MicroRNAs in cancer_Homo sapiens_hsa052060.41702447
84Hepatitis C_Homo sapiens_hsa051600.41521653
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40475970
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40361167
87Alzheimers disease_Homo sapiens_hsa050100.38772468
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.37305900
89Hepatitis B_Homo sapiens_hsa051610.36753859
90Acute myeloid leukemia_Homo sapiens_hsa052210.35912465
91Starch and sucrose metabolism_Homo sapiens_hsa005000.34545190
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34087930
93ErbB signaling pathway_Homo sapiens_hsa040120.33576411
94VEGF signaling pathway_Homo sapiens_hsa043700.33408283
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33366519
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33354791
97Oocyte meiosis_Homo sapiens_hsa041140.32842766
98Legionellosis_Homo sapiens_hsa051340.31550451
99Parkinsons disease_Homo sapiens_hsa050120.31290078
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31197306

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