MYH11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hypotonic response (GO:0006971)7.44777477
2cGMP-mediated signaling (GO:0019934)5.74564828
3urinary tract smooth muscle contraction (GO:0014848)5.60000598
4tonic smooth muscle contraction (GO:0014820)5.22045827
5galactose catabolic process (GO:0019388)4.86417930
6relaxation of smooth muscle (GO:0044557)4.51344929
7response to parathyroid hormone (GO:0071107)4.31910719
8UDP-N-acetylglucosamine metabolic process (GO:0006047)3.89655926
9protein heterotrimerization (GO:0070208)3.78242322
10renal filtration (GO:0097205)3.75920093
11peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.69902939
12* smooth muscle contraction (GO:0006939)3.69249744
13apoptotic cell clearance (GO:0043277)3.67565572
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.65266222
15glomerular filtration (GO:0003094)3.64367689
16transcytosis (GO:0045056)3.58941026
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.56056864
18interkinetic nuclear migration (GO:0022027)3.50513609
19cellular response to osmotic stress (GO:0071470)3.48397896
20fibroblast migration (GO:0010761)3.47067205
21negative regulation of myotube differentiation (GO:0010832)3.41456897
22endothelial cell chemotaxis (GO:0035767)3.38182633
23regulation of skeletal muscle contraction (GO:0014819)3.36794327
24hemidesmosome assembly (GO:0031581)3.29534309
25mannose metabolic process (GO:0006013)3.29436069
26smooth muscle tissue development (GO:0048745)3.28437088
27branching involved in prostate gland morphogenesis (GO:0060442)3.24259561
28relaxation of muscle (GO:0090075)3.17308789
29ovulation from ovarian follicle (GO:0001542)3.16734301
30nucleus localization (GO:0051647)3.15248139
31endocrine hormone secretion (GO:0060986)3.13011856
32sulfur amino acid catabolic process (GO:0000098)3.11811939
33extracellular fibril organization (GO:0043206)3.11798957
34lung lobe morphogenesis (GO:0060463)3.11736717
35epithelial cell differentiation involved in prostate gland development (GO:0060742)3.11290550
36positive regulation of vascular permeability (GO:0043117)3.05562343
37Golgi transport vesicle coating (GO:0048200)3.04377620
38COPI coating of Golgi vesicle (GO:0048205)3.04377620
39negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.04250199
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.03919457
41retina vasculature morphogenesis in camera-type eye (GO:0061299)3.02128905
42positive regulation of respiratory burst (GO:0060267)2.97436331
43regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.96386480
44multicellular organismal macromolecule metabolic process (GO:0044259)2.96063585
45collagen metabolic process (GO:0032963)2.95741663
46phospholipid scrambling (GO:0017121)2.94751350
47response to inactivity (GO:0014854)2.94140703
48prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.91915657
49positive regulation of glycogen biosynthetic process (GO:0045725)2.91343965
50negative regulation of smooth muscle contraction (GO:0045986)2.89949632
51collagen fibril organization (GO:0030199)2.89821625
52collagen catabolic process (GO:0030574)2.88815492
53potassium ion homeostasis (GO:0055075)2.87750753
54keratan sulfate catabolic process (GO:0042340)2.86824420
55regulation of p38MAPK cascade (GO:1900744)2.86782899
56valine metabolic process (GO:0006573)2.86367516
57multicellular organismal metabolic process (GO:0044236)2.85588443
58multicellular organismal catabolic process (GO:0044243)2.84926436
59import into cell (GO:0098657)2.84564122
60vascular endothelial growth factor signaling pathway (GO:0038084)2.84290651
61cyclooxygenase pathway (GO:0019371)2.77117205
62galactose metabolic process (GO:0006012)2.76935283
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75978382
64negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.75392582
65protein localization to cell surface (GO:0034394)2.74472198
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73936474
67fibril organization (GO:0097435)2.73908522
68cellular response to epinephrine stimulus (GO:0071872)2.72751869
69actin filament depolymerization (GO:0030042)2.71732363
70epithelial cell-cell adhesion (GO:0090136)2.71556579
71positive regulation of natural killer cell differentiation (GO:0032825)2.71534726
72cell-substrate junction assembly (GO:0007044)2.71111929
73pathway-restricted SMAD protein phosphorylation (GO:0060389)2.69716799
74endothelial cell morphogenesis (GO:0001886)2.69132725
75growth hormone receptor signaling pathway (GO:0060396)2.67788236
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67654080
77lung vasculature development (GO:0060426)2.65473086
78stress fiber assembly (GO:0043149)2.65387314
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.64404864
80response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.64132356
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63797401
82sexual reproduction (GO:0019953)2.63348096
83barbed-end actin filament capping (GO:0051016)2.62907721
84bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62761988
85glomerular basement membrane development (GO:0032836)2.62348423
86platelet aggregation (GO:0070527)2.59933474
87skin morphogenesis (GO:0043589)2.59443333
88carnitine shuttle (GO:0006853)2.58405507
89mesodermal cell differentiation (GO:0048333)2.55203759
90regulation of cardiac muscle hypertrophy (GO:0010611)2.54309271
91cell migration involved in heart development (GO:0060973)2.53735978
92adherens junction assembly (GO:0034333)2.53713292
93ovulation (GO:0030728)2.53402396
94regulation of pigment cell differentiation (GO:0050932)2.52726805
95relaxation of cardiac muscle (GO:0055119)2.50789778
96cell volume homeostasis (GO:0006884)2.49940224
97fatty acid transmembrane transport (GO:1902001)2.49544490
98motile cilium assembly (GO:0044458)2.49288414
99positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.47669435
100focal adhesion assembly (GO:0048041)2.46709189
101cell-substrate adherens junction assembly (GO:0007045)2.46709189
102coronary vasculature morphogenesis (GO:0060977)2.46421647
103extracellular matrix disassembly (GO:0022617)2.46160226
104intestinal epithelial cell development (GO:0060576)2.46094711
105gland morphogenesis (GO:0022612)2.44937527
106regulation of muscle hypertrophy (GO:0014743)2.44781275
107positive regulation of glycogen metabolic process (GO:0070875)2.43741102
108* muscle contraction (GO:0006936)2.42235586
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41525741
110hormone catabolic process (GO:0042447)2.41270015
111negative regulation of fatty acid transport (GO:2000192)2.39717244
112metanephric nephron tubule development (GO:0072234)2.38437285
113metanephric tubule development (GO:0072170)2.38437285
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.38036050
115regulation of muscle contraction (GO:0006937)2.37095872
116regulation of muscle system process (GO:0090257)2.36615146
117negative regulation of protein autophosphorylation (GO:0031953)2.36572500
118myofibril assembly (GO:0030239)2.36161984
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.36155931
120sequestering of extracellular ligand from receptor (GO:0035581)2.35718270
121regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.35544267
122endocardial cushion morphogenesis (GO:0003203)2.34648887
123basement membrane organization (GO:0071711)2.34149186
124protein localization to endosome (GO:0036010)2.34081009
125* muscle system process (GO:0003012)2.33900696
126regulation of smooth muscle cell differentiation (GO:0051150)2.33729494
127low-density lipoprotein particle clearance (GO:0034383)2.33500379
128positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.32972169
129cellular response to growth hormone stimulus (GO:0071378)2.31666278
130N-glycan processing (GO:0006491)2.30862745
131negative regulation of muscle contraction (GO:0045932)2.30311250
132artery development (GO:0060840)2.30266730
133positive regulation of fatty acid oxidation (GO:0046321)2.29043751
134regulation of smooth muscle contraction (GO:0006940)2.29013844
135creatine metabolic process (GO:0006600)2.28338400
136cardiac myofibril assembly (GO:0055003)2.28147729
137complement activation, alternative pathway (GO:0006957)2.28095346
138response to epinephrine (GO:0071871)2.27048321
139sodium ion homeostasis (GO:0055078)2.26462086
140insulin-like growth factor receptor signaling pathway (GO:0048009)2.26009486
141anterior/posterior axis specification, embryo (GO:0008595)2.25425360
142one-carbon compound transport (GO:0019755)2.24907242
143iron ion import (GO:0097286)2.24819754
144positive regulation of cGMP biosynthetic process (GO:0030828)2.22617514
145mesenchyme morphogenesis (GO:0072132)2.22059729
146heart morphogenesis (GO:0003007)2.21984143
147regulation of muscle adaptation (GO:0043502)2.21167037
148positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.21120362
149peptide cross-linking (GO:0018149)2.20763893
150regulation of cGMP biosynthetic process (GO:0030826)2.20643331
151* extracellular matrix assembly (GO:0085029)2.20615644
152metanephric nephron epithelium development (GO:0072243)2.20533877
153regulation of SMAD protein import into nucleus (GO:0060390)2.20258631
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19948221
155uterus development (GO:0060065)2.18898104
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17951952
157negative regulation of complement activation (GO:0045916)2.17720370
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.17447467
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.17447467
160regulation of macrophage cytokine production (GO:0010935)2.17370078
161growth hormone secretion (GO:0030252)2.17215931
162fucose catabolic process (GO:0019317)2.17039100
163L-fucose metabolic process (GO:0042354)2.17039100
164L-fucose catabolic process (GO:0042355)2.17039100
165L-serine transport (GO:0015825)2.16924419
166negative regulation of cardiac muscle tissue growth (GO:0055022)2.16469670
167negative regulation of heart growth (GO:0061117)2.16469670
168cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.16403796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.33079514
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.31015700
3CLOCK_20551151_ChIP-Seq_293T_Human3.17907247
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.89467406
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.74423202
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.73859305
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.73197758
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.67801171
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49762997
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38386915
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.13565866
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.02657872
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00644614
14SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98502308
15PPAR_26484153_Chip-Seq_NCI-H1993_Human1.98283362
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.97611518
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94581055
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93332039
19SOX2_20726797_ChIP-Seq_SW620_Human1.91147609
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.90785557
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88419712
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87308063
23GBX2_23144817_ChIP-Seq_PC3_Human1.83344847
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.81610653
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78579580
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77334287
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.75207818
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74778360
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72725480
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71852573
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70788669
32CJUN_26792858_Chip-Seq_BT549_Human1.69697597
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.63634384
34ZNF263_19887448_ChIP-Seq_K562_Human1.61331788
35AR_21572438_ChIP-Seq_LNCaP_Human1.59895565
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.58454038
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56281730
38EZH2_22144423_ChIP-Seq_EOC_Human1.54924961
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.53724005
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53416058
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50823425
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49114603
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48803459
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48475400
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45981214
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.45146707
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44326343
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43328874
49VDR_22108803_ChIP-Seq_LS180_Human1.41980652
50* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41011287
51* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41011287
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39902147
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39545441
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.37116302
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.37116302
56GATA4_25053715_ChIP-Seq_YYC3_Human1.35200936
57RACK7_27058665_Chip-Seq_MCF-7_Human1.34743263
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33002693
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29424332
60* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29297267
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28518741
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28518741
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28493505
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27293946
65AHR_22903824_ChIP-Seq_MCF-7_Human1.26772158
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25392213
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25192435
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.24547051
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21728110
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21275734
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20424673
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20279408
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19514079
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19470549
75GATA1_22025678_ChIP-Seq_K562_Human1.18309417
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18304379
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17691220
78SMAD4_21799915_ChIP-Seq_A2780_Human1.15836435
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.13197809
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.13003881
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.12525549
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.11762370
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11700366
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.11453319
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11254279
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10923859
87TP53_16413492_ChIP-PET_HCT116_Human1.10218765
88GATA6_25053715_ChIP-Seq_YYC3_Human1.09743975
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09662913
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08931568
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.08472017
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08258879
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.08031320
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07931927
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07801798
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05692777
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.05496980
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05468195
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05417134
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05376535
101KLF5_25053715_ChIP-Seq_YYC3_Human1.04767531
102ISL1_27105846_Chip-Seq_CPCs_Mouse1.04293129
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03764216
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03594926
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03062010
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.02877164
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02850864
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02011398
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.01956771
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01349629
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00300993
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.99794197
113BCAT_22108803_ChIP-Seq_LS180_Human0.99031014
114JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98748571
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97536521
116BRD4_25478319_ChIP-Seq_HGPS_Human0.96852645
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96028992
118EZH2_27304074_Chip-Seq_ESCs_Mouse0.95659540
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.94112145
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92532755
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92248871
122RXR_22108803_ChIP-Seq_LS180_Human0.91460758
123RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91323103
124EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91323103
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91100670
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90286938
127ATF3_27146783_Chip-Seq_COLON_Human0.89234299
128KDM2B_26808549_Chip-Seq_K562_Human0.89199427
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88822632
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.88421542
131* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88344775
132DROSHA_22980978_ChIP-Seq_HELA_Human0.88246177
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87371334
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86941530
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86905225
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86160375
137* TCF4_23295773_ChIP-Seq_U87_Human0.84847232
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84377710
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83854847
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83630709
141TP53_18474530_ChIP-ChIP_U2OS_Human0.83537480
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83085867
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82921930
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82921930
145VDR_24787735_ChIP-Seq_THP-1_Human0.81720568
146AR_19668381_ChIP-Seq_PC3_Human0.80782584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder5.45127373
2MP0008438_abnormal_cutaneous_collagen4.21223273
3MP0006054_spinal_hemorrhage2.99600207
4MP0000516_abnormal_urinary_system2.96253323
5MP0005367_renal/urinary_system_phenotyp2.96253323
6MP0005275_abnormal_skin_tensile2.91060292
7MP0010234_abnormal_vibrissa_follicle2.79070943
8MP0001958_emphysema2.73312606
9MP0002837_dystrophic_cardiac_calcinosis2.49112233
10MP0008004_abnormal_stomach_pH2.48539800
11MP0004272_abnormal_basement_membrane2.48318249
12MP0002254_reproductive_system_inflammat2.43934507
13MP0000013_abnormal_adipose_tissue2.30190308
14MP0000751_myopathy2.28692611
15MP0003300_gastrointestinal_ulcer2.28520545
16MP0004036_abnormal_muscle_relaxation2.25684529
17MP0003045_fibrosis2.17012900
18MP0003705_abnormal_hypodermis_morpholog2.14450905
19MP0000537_abnormal_urethra_morphology2.09298398
20* MP0001664_abnormal_digestion1.98179906
21MP0004145_abnormal_muscle_electrophysio1.94965626
22MP0004147_increased_porphyrin_level1.94149030
23MP0003566_abnormal_cell_adhesion1.93216187
24MP0002166_altered_tumor_susceptibility1.87748285
25MP0003011_delayed_dark_adaptation1.81086123
26MP0000534_abnormal_ureter_morphology1.81016445
27MP0004185_abnormal_adipocyte_glucose1.80551675
28* MP0001756_abnormal_urination1.78432843
29MP0010352_gastrointestinal_tract_polyps1.77468295
30MP0004130_abnormal_muscle_cell1.68544607
31MP0005666_abnormal_adipose_tissue1.65315404
32MP0003866_abnormal_defecation1.64525941
33MP0003279_aneurysm1.64318908
34MP0004084_abnormal_cardiac_muscle1.51338522
35MP0000750_abnormal_muscle_regeneration1.49211792
36MP0005375_adipose_tissue_phenotype1.48778338
37MP0005164_abnormal_response_to1.48030480
38MP0009384_cardiac_valve_regurgitation1.45794193
39MP0000003_abnormal_adipose_tissue1.44165620
40MP0005503_abnormal_tendon_morphology1.43934134
41MP0004043_abnormal_pH_regulation1.41136901
42MP0005409_darkened_coat_color1.39441285
43MP0002933_joint_inflammation1.39330219
44* MP0005620_abnormal_muscle_contractility1.38186782
45* MP0000230_abnormal_systemic_arterial1.36587900
46MP0001765_abnormal_ion_homeostasis1.35041234
47MP0000767_abnormal_smooth_muscle1.33927805
48MP0002009_preneoplasia1.27621740
49MP0003879_abnormal_hair_cell1.26346328
50MP0001663_abnormal_digestive_system1.24998605
51MP0002127_abnormal_cardiovascular_syste1.24660389
52MP0001542_abnormal_bone_strength1.23097475
53MP0002006_tumorigenesis1.22068884
54MP0000749_muscle_degeneration1.19690599
55MP0009780_abnormal_chondrocyte_physiolo1.19356391
56MP0005023_abnormal_wound_healing1.17339909
57MP0002060_abnormal_skin_morphology1.16342430
58MP0005670_abnormal_white_adipose1.16011408
59MP0004264_abnormal_extraembryonic_tissu1.14455695
60MP0003091_abnormal_cell_migration1.13436033
61MP0010155_abnormal_intestine_physiology1.13131364
62MP0002295_abnormal_pulmonary_circulatio1.13067749
63* MP0005381_digestive/alimentary_phenotyp1.11525268
64MP0001873_stomach_inflammation1.10643676
65MP0005508_abnormal_skeleton_morphology1.05944707
66MP0001881_abnormal_mammary_gland1.05455019
67MP0005166_decreased_susceptibility_to1.05252389
68MP0002115_abnormal_skeleton_extremities1.05158301
69MP0003868_abnormal_feces_composition1.02911278
70MP0001501_abnormal_sleep_pattern1.02851555
71MP0001666_abnormal_nutrient_absorption1.01793800
72MP0005310_abnormal_salivary_gland1.01450123
73MP0001879_abnormal_lymphatic_vessel1.00479069
74MP0004215_abnormal_myocardial_fiber0.97986264
75MP0010368_abnormal_lymphatic_system0.97479366
76MP0000465_gastrointestinal_hemorrhage0.96163648
77MP0006138_congestive_heart_failure0.95162074
78MP0002128_abnormal_blood_circulation0.94125727
79MP0001270_distended_abdomen0.93980231
80MP0000343_altered_response_to0.93560883
81MP0004484_altered_response_of0.93054784
82* MP0005330_cardiomyopathy0.92973231
83MP0005167_abnormal_blood-brain_barrier0.91848995
84MP0000566_synostosis0.91508328
85MP0000477_abnormal_intestine_morphology0.91288239
86MP0003724_increased_susceptibility_to0.90599638
87MP0009643_abnormal_urine_homeostasis0.90244902
88MP0001661_extended_life_span0.89637800
89MP0002998_abnormal_bone_remodeling0.89412521
90MP0005369_muscle_phenotype0.88471984
91MP0005595_abnormal_vascular_smooth0.86903147
92MP0003828_pulmonary_edema0.85748596
93MP0000470_abnormal_stomach_morphology0.85325286
94MP0000163_abnormal_cartilage_morphology0.84919542
95MP0000249_abnormal_blood_vessel0.84466070
96* MP0000462_abnormal_digestive_system0.84061226
97MP0005076_abnormal_cell_differentiation0.83494564
98MP0009115_abnormal_fat_cell0.82693183
99MP0004085_abnormal_heartbeat0.81767999
100MP0002896_abnormal_bone_mineralization0.80488306
101MP0002106_abnormal_muscle_physiology0.79425837
102MP0005165_increased_susceptibility_to0.78478047
103MP0002136_abnormal_kidney_physiology0.77281842
104MP0005390_skeleton_phenotype0.76717998
105MP0002249_abnormal_larynx_morphology0.76600005
106MP0002972_abnormal_cardiac_muscle0.76387431
107MP0002168_other_aberrant_phenotype0.75538174
108MP0003283_abnormal_digestive_organ0.75092536
109MP0005623_abnormal_meninges_morphology0.75044092
110MP0003303_peritoneal_inflammation0.75011464
111MP0003191_abnormal_cellular_cholesterol0.74806220
112MP0003385_abnormal_body_wall0.74628774
113* MP0004087_abnormal_muscle_fiber0.74297070
114MP0004883_abnormal_blood_vessel0.73053636
115MP0005647_abnormal_sex_gland0.72784639
116MP0002269_muscular_atrophy0.72528898
117MP0010630_abnormal_cardiac_muscle0.72359115
118MP0003950_abnormal_plasma_membrane0.72345821
119MP0002108_abnormal_muscle_morphology0.70079725
120MP0002133_abnormal_respiratory_system0.69738104
121MP0005388_respiratory_system_phenotype0.69738104
122MP0005385_cardiovascular_system_phenoty0.69487345
123MP0001544_abnormal_cardiovascular_syste0.69487345
124MP0004510_myositis0.69349221
125MP0010678_abnormal_skin_adnexa0.69039428
126MP0005187_abnormal_penis_morphology0.68566535
127MP0001533_abnormal_skeleton_physiology0.68421439
128MP0003137_abnormal_impulse_conducting0.67423120
129MP0008775_abnormal_heart_ventricle0.67226716
130MP0000627_abnormal_mammary_gland0.66585302
131MP0000733_abnormal_muscle_development0.65669653
132* MP0001614_abnormal_blood_vessel0.65140959
133MP0010030_abnormal_orbit_morphology0.64616101
134MP0001502_abnormal_circadian_rhythm0.63860352

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)8.02487979
2* Aortic aneurysm (HP:0004942)6.91460511
3Facial diplegia (HP:0001349)6.85405348
4Increased density of long bones (HP:0006392)6.16066534
5* Aortic dissection (HP:0002647)6.02813813
6Ankle contracture (HP:0006466)4.88245824
7Cerebral aneurysm (HP:0004944)4.48950434
8Gastrointestinal dysmotility (HP:0002579)4.11936185
9Type 1 muscle fiber predominance (HP:0003803)4.08508735
10Neoplasm of the heart (HP:0100544)4.02062867
11Malnutrition (HP:0004395)3.85511566
12Right ventricular cardiomyopathy (HP:0011663)3.72381562
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.52069465
14Short hallux (HP:0010109)3.50182555
15Ulnar bowing (HP:0003031)3.33300326
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.33205403
17Osteolytic defects of the hand bones (HP:0009699)3.33205403
18Aplasia/Hypoplasia of the hallux (HP:0008362)3.22104390
19Bronchomalacia (HP:0002780)3.21164755
20Pulmonary artery stenosis (HP:0004415)3.11849834
21Broad metatarsal (HP:0001783)3.05251255
22Increased connective tissue (HP:0009025)3.04410972
23Radial bowing (HP:0002986)3.01261929
24* Aneurysm (HP:0002617)2.96527787
25Broad ribs (HP:0000885)2.94154150
26Scapular winging (HP:0003691)2.91064978
27Hyporeflexia of lower limbs (HP:0002600)2.90126976
28Rectal prolapse (HP:0002035)2.85178001
29Long toe (HP:0010511)2.79387250
30Prolonged QT interval (HP:0001657)2.78199843
31Overgrowth (HP:0001548)2.76008919
32Dilatation of the ascending aorta (HP:0005111)2.71242664
33Premature rupture of membranes (HP:0001788)2.68674240
34Absent frontal sinuses (HP:0002688)2.63428671
35Mitral valve prolapse (HP:0001634)2.61018772
36Abnormality of the calcaneus (HP:0008364)2.60109536
37Sudden death (HP:0001699)2.59185062
38Wrist flexion contracture (HP:0001239)2.52743201
39Obstructive sleep apnea (HP:0002870)2.46179608
40Mildly elevated creatine phosphokinase (HP:0008180)2.45254413
41Increased variability in muscle fiber diameter (HP:0003557)2.44850482
42Muscle fiber splitting (HP:0003555)2.44763924
43Abnormality of the 2nd finger (HP:0004100)2.43412514
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43157950
45Short 4th metacarpal (HP:0010044)2.43157950
46Testicular atrophy (HP:0000029)2.42431543
47Persistence of primary teeth (HP:0006335)2.40192300
48Stridor (HP:0010307)2.37859631
49Tarsal synostosis (HP:0008368)2.37509814
50Arterial tortuosity (HP:0005116)2.34670822
51Protrusio acetabuli (HP:0003179)2.34543214
52Bowing of the arm (HP:0006488)2.34260755
53Bowed forearm bones (HP:0003956)2.34260755
54Hip contracture (HP:0003273)2.33238074
55Laryngomalacia (HP:0001601)2.31225704
56Abnormal foot bone ossification (HP:0010675)2.30897653
57Abnormality of the 4th metacarpal (HP:0010012)2.28600153
58Vascular tortuosity (HP:0004948)2.27259868
59Neonatal short-limb short stature (HP:0008921)2.26321330
60Hydroureter (HP:0000072)2.25405577
61Atrophic scars (HP:0001075)2.24898827
62Wide anterior fontanel (HP:0000260)2.24444806
63Limited hip movement (HP:0008800)2.23833151
64Syncope (HP:0001279)2.22527093
65Abnormality of the calf musculature (HP:0001430)2.17065287
66Myopathic facies (HP:0002058)2.16388107
67Mesomelia (HP:0003027)2.16202211
68Round ear (HP:0100830)2.15381369
69Tracheomalacia (HP:0002779)2.14523635
70Dysmetric saccades (HP:0000641)2.13876155
71Genetic anticipation (HP:0003743)2.13567906
72Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.12944602
73Abnormality of the phalanges of the hallux (HP:0010057)2.11743053
74Elbow flexion contracture (HP:0002987)2.11094152
75Spinal rigidity (HP:0003306)2.10954430
76Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.10439650
77Abnormality of abdominal situs (HP:0011620)2.10162227
78Abdominal situs inversus (HP:0003363)2.10162227
79Long foot (HP:0001833)2.09913575
80Synostosis involving bones of the feet (HP:0009140)2.08653907
81Synostosis involving bones of the lower limbs (HP:0009138)2.08653907
82Follicular hyperkeratosis (HP:0007502)2.07161308
83Wormian bones (HP:0002645)2.06005344
84Hypoventilation (HP:0002791)2.05462009
85Abnormality of skeletal muscle fiber size (HP:0012084)2.05430236
86Camptodactyly of toe (HP:0001836)2.04015583
87Abnormality of the fingertips (HP:0001211)1.98674498
88Ureteral stenosis (HP:0000071)1.98425732
89Knee flexion contracture (HP:0006380)1.98186233
90Ulnar deviation of the wrist (HP:0003049)1.97307057
91Distal arthrogryposis (HP:0005684)1.96759824
92Short clavicles (HP:0000894)1.95548255
93Broad distal phalanx of finger (HP:0009836)1.94750958
94Ileus (HP:0002595)1.93727805
95Craniofacial hyperostosis (HP:0004493)1.93233154
96Preaxial foot polydactyly (HP:0001841)1.91777270
97* Aortic regurgitation (HP:0001659)1.87280569
98Decreased circulating renin level (HP:0003351)1.87001711
99Ureteral obstruction (HP:0006000)1.86931397
100Ventricular tachycardia (HP:0004756)1.86259881
101Facial shape deformation (HP:0011334)1.85943849
102Potter facies (HP:0002009)1.85943849
103Fibular hypoplasia (HP:0003038)1.84435918
104Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83381849
105Lymphangioma (HP:0100764)1.83346632
106Atrial fibrillation (HP:0005110)1.83324908
107Mesangial abnormality (HP:0001966)1.82780697
108Broad face (HP:0000283)1.81233058
109Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80772283
110Spastic diplegia (HP:0001264)1.80645390
111Short chin (HP:0000331)1.79944536
112Coronal craniosynostosis (HP:0004440)1.79534844
113Fragile skin (HP:0001030)1.78614134
114Hyperparathyroidism (HP:0000843)1.78415654
115Abnormal cortical bone morphology (HP:0003103)1.78066438
116Hyperventilation (HP:0002883)1.77259472
117Hypoplasia of the iris (HP:0007676)1.76628772
118Complement deficiency (HP:0004431)1.75795038
119Joint laxity (HP:0001388)1.75477131
120Choanal stenosis (HP:0000452)1.75308069
121Hematochezia (HP:0002573)1.74508991
122Abnormality of the epiphyses of the hand (HP:0005924)1.74498241
123Flared iliac wings (HP:0002869)1.74481391
124Increased mean platelet volume (HP:0011877)1.74389717
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.74276114
126Soft skin (HP:0000977)1.73782027
127Hydronephrosis (HP:0000126)1.73390494
128Tibial bowing (HP:0002982)1.73374864
129Visceral angiomatosis (HP:0100761)1.73204526
130Abnormality of the right ventricle (HP:0001707)1.72933530
131Abnormality of the axillary hair (HP:0100134)1.72777698
132Abnormality of secondary sexual hair (HP:0009888)1.72777698
133Round face (HP:0000311)1.72314687
134Cervical subluxation (HP:0003308)1.72298556
135Abnormal ossification of hand bones (HP:0005921)1.72269395
136Spondylolisthesis (HP:0003302)1.72034443
137Short metatarsal (HP:0010743)1.70883189
138Lipoatrophy (HP:0100578)1.70854670
139Aplasia/Hypoplasia of the clavicles (HP:0006710)1.70418823
140Shallow orbits (HP:0000586)1.70263362
141Hypoplasia of the maxilla (HP:0000327)1.68335199
142Vertebral arch anomaly (HP:0008438)1.67079883
143Striae distensae (HP:0001065)1.62755708
144Emphysema (HP:0002097)1.62240946
145Omphalocele (HP:0001539)1.61298956
146Narrow palate (HP:0000189)1.59311285
147Hyperactive renin-angiotensin system (HP:0000841)1.58621421
148Duplicated collecting system (HP:0000081)1.58468847
149Dislocated radial head (HP:0003083)1.58112224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK8.92656954
2TTN6.03776869
3DMPK3.94205434
4PIK3CG2.86929538
5LMTK22.80476903
6PAK22.66446718
7FRK2.54541924
8AKT32.28708035
9ERN11.85679040
10LATS11.81911946
11PDGFRA1.79875326
12NUAK11.76533962
13MST41.70395804
14TRIB31.70227312
15NLK1.69134598
16STK391.66919217
17EEF2K1.64900990
18RIPK11.64231990
19DDR21.56951421
20MAPKAPK31.47526770
21PIK3CA1.47490029
22MST1R1.44902211
23TESK11.36372718
24CDC42BPA1.31304701
25TGFBR21.31273723
26MAP3K61.31114037
27SIK11.19951441
28MARK21.16187210
29PDK21.14306329
30TAOK31.11295600
31EPHB21.08835935
32ACVR1B1.08768281
33FER1.05262107
34PTK61.04568979
35ROCK11.03890297
36SGK20.98316218
37DAPK30.93040657
38CAMK1D0.93039010
39MET0.91682835
40MAP3K20.88690949
41SGK2230.86192800
42SGK4940.86192800
43CAMK2G0.84300769
44PAK10.82561980
45EPHB10.81921481
46RPS6KA20.76051950
47ILK0.75872256
48LIMK10.73049232
49FGFR20.71960578
50LRRK20.71908793
51MAPK70.70391320
52STK380.70119293
53PTK20.68368415
54MAPK150.68205345
55CAMK1G0.67904860
56PDGFRB0.66659227
57BCKDK0.66132762
58TIE10.65882495
59OXSR10.65633151
60SGK30.65583165
61PKN20.64768501
62PRKAA10.64483404
63PAK30.64011870
64GSK3A0.63383015
65WNK10.63045912
66PDK30.62708388
67PDK40.62708388
68HIPK20.62669119
69CAMK40.56980601
70RAF10.55877356
71MAPK120.55433931
72ROCK20.54346684
73PRKD20.53748074
74PTK2B0.52398352
75SCYL20.51478048
76MELK0.51292756
77CHUK0.50461717
78MAP2K10.49324635
79PHKG10.47586385
80PHKG20.47586385
81CDK120.47554960
82STK30.47434223
83NEK90.47392028
84TRPM70.46702632
85MAP3K30.45945887
86RPS6KB20.45196645
87EPHA30.44666669
88KSR20.40643218
89MAPK10.39864081
90PRKG20.39723152
91CLK10.39029981
92STK38L0.38961680
93PRKAA20.38543994
94MAP2K20.37536521
95CAMK10.37386055
96MAP3K130.36817118
97TNK20.36137649
98MAPK30.35790857
99JAK10.35747331
100MTOR0.35325587
101MAP3K70.35295154
102RET0.35107172
103FGFR40.34882709
104RPS6KC10.34267896
105RPS6KL10.34267896
106IRAK10.33948645
107FYN0.33265504
108MAPKAPK20.32614339
109TGFBR10.32512473
110ERBB20.32055938
111BMPR1B0.31553369
112FGFR30.31410256
113INSRR0.30432627
114ADRBK10.29571696
115PRKACB0.28647086
116OBSCN0.28584382
117STK100.27944995
118EPHA20.27634940
119JAK30.26902633
120STK240.26516988
121RPS6KA60.26236425
122PRKCH0.26132108
123NTRK10.25062116
124JAK20.24679086
125PRKD10.24670586
126KIT0.24620857
127MAPK40.24143164
128PDPK10.23603456
129PAK40.23084135
130LATS20.22780717
131CAMK2D0.21991475
132INSR0.21887193
133SRC0.21738307
134MAPKAPK50.21669536
135ICK0.20974994

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.01189431
2Sulfur metabolism_Homo sapiens_hsa009202.80983195
3Focal adhesion_Homo sapiens_hsa045102.68629987
4* Vascular smooth muscle contraction_Homo sapiens_hsa042702.60118522
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15913154
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.04235934
7Protein digestion and absorption_Homo sapiens_hsa049741.94841572
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88522101
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.86362671
10Amoebiasis_Homo sapiens_hsa051461.86309304
11Dilated cardiomyopathy_Homo sapiens_hsa054141.77190344
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69406953
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66169852
14Gastric acid secretion_Homo sapiens_hsa049711.62020293
15PPAR signaling pathway_Homo sapiens_hsa033201.56376726
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.48161910
17Circadian rhythm_Homo sapiens_hsa047101.46371324
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42928062
19Proteoglycans in cancer_Homo sapiens_hsa052051.38211391
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.36578782
21Adherens junction_Homo sapiens_hsa045201.35647886
22Platelet activation_Homo sapiens_hsa046111.35383912
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34785762
24Small cell lung cancer_Homo sapiens_hsa052221.31506725
25Fatty acid biosynthesis_Homo sapiens_hsa000611.28262632
26Fatty acid degradation_Homo sapiens_hsa000711.26927145
27Bile secretion_Homo sapiens_hsa049761.26570577
28Nitrogen metabolism_Homo sapiens_hsa009101.26501679
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26249940
30Renin secretion_Homo sapiens_hsa049241.24872709
31* Tight junction_Homo sapiens_hsa045301.22994715
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20419304
33Propanoate metabolism_Homo sapiens_hsa006401.20308947
34Circadian entrainment_Homo sapiens_hsa047131.18003276
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17931648
36Insulin secretion_Homo sapiens_hsa049111.15033503
37Notch signaling pathway_Homo sapiens_hsa043301.13023181
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10438291
39Fatty acid metabolism_Homo sapiens_hsa012121.10371914
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08981547
41Mineral absorption_Homo sapiens_hsa049781.08504582
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06327442
43Caffeine metabolism_Homo sapiens_hsa002321.06186908
44Oxytocin signaling pathway_Homo sapiens_hsa049211.05959326
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05839997
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04794616
47TGF-beta signaling pathway_Homo sapiens_hsa043501.04212112
48Insulin resistance_Homo sapiens_hsa049311.04072008
49ABC transporters_Homo sapiens_hsa020101.01344935
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.00896339
51Phenylalanine metabolism_Homo sapiens_hsa003600.99604611
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91147273
53Bladder cancer_Homo sapiens_hsa052190.89662621
54FoxO signaling pathway_Homo sapiens_hsa040680.89163277
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87969188
56Toxoplasmosis_Homo sapiens_hsa051450.87819474
57Thyroid hormone synthesis_Homo sapiens_hsa049180.86679189
58Salivary secretion_Homo sapiens_hsa049700.85506243
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.83977532
60Cholinergic synapse_Homo sapiens_hsa047250.82748068
61mTOR signaling pathway_Homo sapiens_hsa041500.81834657
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81502844
63Type II diabetes mellitus_Homo sapiens_hsa049300.80341458
64AMPK signaling pathway_Homo sapiens_hsa041520.80315816
65Long-term potentiation_Homo sapiens_hsa047200.79587150
66Glycerolipid metabolism_Homo sapiens_hsa005610.78432543
67Other glycan degradation_Homo sapiens_hsa005110.78356961
68Renin-angiotensin system_Homo sapiens_hsa046140.77547665
69Choline metabolism in cancer_Homo sapiens_hsa052310.77161535
70Lysosome_Homo sapiens_hsa041420.75166314
71Amphetamine addiction_Homo sapiens_hsa050310.74372863
72Serotonergic synapse_Homo sapiens_hsa047260.74136764
73Hippo signaling pathway_Homo sapiens_hsa043900.73876424
74N-Glycan biosynthesis_Homo sapiens_hsa005100.73650065
75Fat digestion and absorption_Homo sapiens_hsa049750.72025690
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71102821
77Long-term depression_Homo sapiens_hsa047300.69925709
78Dorso-ventral axis formation_Homo sapiens_hsa043200.69421589
79Pancreatic secretion_Homo sapiens_hsa049720.69211997
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.68588393
81Taste transduction_Homo sapiens_hsa047420.66310055
82Linoleic acid metabolism_Homo sapiens_hsa005910.65020478
83Malaria_Homo sapiens_hsa051440.64841447
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64541858
85MAPK signaling pathway_Homo sapiens_hsa040100.63461788
86cAMP signaling pathway_Homo sapiens_hsa040240.60808553
87Renal cell carcinoma_Homo sapiens_hsa052110.60590888
88TNF signaling pathway_Homo sapiens_hsa046680.60375130
89Glutamatergic synapse_Homo sapiens_hsa047240.59742588
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58420463
91Salmonella infection_Homo sapiens_hsa051320.58290874
92Insulin signaling pathway_Homo sapiens_hsa049100.54988745
93Acute myeloid leukemia_Homo sapiens_hsa052210.54570598
94Vibrio cholerae infection_Homo sapiens_hsa051100.53500687
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53433764
96Chronic myeloid leukemia_Homo sapiens_hsa052200.53144801
97Estrogen signaling pathway_Homo sapiens_hsa049150.52725605
98Glucagon signaling pathway_Homo sapiens_hsa049220.52161140
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52113015
100Cocaine addiction_Homo sapiens_hsa050300.52099423
101Pathways in cancer_Homo sapiens_hsa052000.52082656
102Retinol metabolism_Homo sapiens_hsa008300.51899748
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50876509
104Prolactin signaling pathway_Homo sapiens_hsa049170.50772304
105Melanogenesis_Homo sapiens_hsa049160.50033847
106Pyruvate metabolism_Homo sapiens_hsa006200.49974503
107Vitamin digestion and absorption_Homo sapiens_hsa049770.49962241
108Complement and coagulation cascades_Homo sapiens_hsa046100.49933310
109Pancreatic cancer_Homo sapiens_hsa052120.49836595
110Tyrosine metabolism_Homo sapiens_hsa003500.49296826
111Arachidonic acid metabolism_Homo sapiens_hsa005900.47228511
112beta-Alanine metabolism_Homo sapiens_hsa004100.47011145
113Inositol phosphate metabolism_Homo sapiens_hsa005620.46777505
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46732991
115MicroRNAs in cancer_Homo sapiens_hsa052060.46668693
116Prostate cancer_Homo sapiens_hsa052150.46355764
117Ovarian steroidogenesis_Homo sapiens_hsa049130.45756570
118Calcium signaling pathway_Homo sapiens_hsa040200.44686823
119Endometrial cancer_Homo sapiens_hsa052130.44561199
120Rap1 signaling pathway_Homo sapiens_hsa040150.44344096
121Viral myocarditis_Homo sapiens_hsa054160.43803924
122Gap junction_Homo sapiens_hsa045400.42919685
123VEGF signaling pathway_Homo sapiens_hsa043700.42201425
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42128035
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39238296
126Histidine metabolism_Homo sapiens_hsa003400.38079473
127Tryptophan metabolism_Homo sapiens_hsa003800.37982333
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37725061
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.36479509
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36189030
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35013377
132Starch and sucrose metabolism_Homo sapiens_hsa005000.34935270
133Prion diseases_Homo sapiens_hsa050200.34624818
134GnRH signaling pathway_Homo sapiens_hsa049120.33165156
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32283238
136Lysine degradation_Homo sapiens_hsa003100.31772648

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