MYH13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle tissue regeneration (GO:0043403)9.89321063
2actin-mediated cell contraction (GO:0070252)9.03208582
3negative regulation of skeletal muscle tissue development (GO:0048642)9.00428430
4response to muscle activity (GO:0014850)9.00231190
5vitamin A metabolic process (GO:0006776)7.64695136
6actin filament-based movement (GO:0030048)6.62117534
7cellular response to dexamethasone stimulus (GO:0071549)6.34863725
8response to activity (GO:0014823)6.15304890
9detection of light stimulus involved in visual perception (GO:0050908)6.14211393
10detection of light stimulus involved in sensory perception (GO:0050962)6.14211393
11protein-chromophore linkage (GO:0018298)6.02641574
12regulation of rhodopsin mediated signaling pathway (GO:0022400)6.00365234
13striated muscle adaptation (GO:0014888)5.94273677
14response to dexamethasone (GO:0071548)5.86312389
15skeletal muscle contraction (GO:0003009)5.80594042
16regulation of posttranscriptional gene silencing (GO:0060147)5.79490933
17regulation of gene silencing by miRNA (GO:0060964)5.79490933
18regulation of gene silencing by RNA (GO:0060966)5.79490933
19cellular response to electrical stimulus (GO:0071257)5.75335241
20rhodopsin mediated signaling pathway (GO:0016056)5.61108974
21regulation of muscle hypertrophy (GO:0014743)5.55516561
22response to electrical stimulus (GO:0051602)5.47891112
23regulation of helicase activity (GO:0051095)5.43655402
24somatic hypermutation of immunoglobulin genes (GO:0016446)5.19587932
25somatic diversification of immune receptors via somatic mutation (GO:0002566)5.19587932
26determination of adult lifespan (GO:0008340)5.08213366
27nuclear pore organization (GO:0006999)5.01057994
28myotube cell development (GO:0014904)4.90654688
29muscle adaptation (GO:0043500)4.84438831
30formation of translation preinitiation complex (GO:0001731)4.84245785
31negative regulation of striated muscle tissue development (GO:0045843)4.70519540
32nuclear pore complex assembly (GO:0051292)4.68457818
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.66573321
34skeletal muscle fiber development (GO:0048741)4.58662394
35muscle organ development (GO:0007517)4.58092702
36histone arginine methylation (GO:0034969)4.57497092
37histone H4-K12 acetylation (GO:0043983)4.52720551
38negative regulation of muscle tissue development (GO:1901862)4.51238696
39muscle structure development (GO:0061061)4.49673088
40protein trimerization (GO:0070206)4.46633381
41negative regulation of muscle organ development (GO:0048635)4.43794923
42DNA replication initiation (GO:0006270)4.43295812
43mitotic sister chromatid segregation (GO:0000070)4.42684838
44regulation of translational fidelity (GO:0006450)4.30046464
45anterior/posterior axis specification, embryo (GO:0008595)4.15127532
46DNA replication-dependent nucleosome organization (GO:0034723)4.14994285
47DNA replication-dependent nucleosome assembly (GO:0006335)4.14994285
48protein localization to kinetochore (GO:0034501)4.06289160
49tissue regeneration (GO:0042246)4.02476569
50response to inactivity (GO:0014854)4.00043624
51negative regulation of fatty acid biosynthetic process (GO:0045717)3.99050314
52negative regulation of heart growth (GO:0061117)3.97916558
53negative regulation of cardiac muscle tissue growth (GO:0055022)3.97916558
54positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.97525146
55negative regulation of androgen receptor signaling pathway (GO:0060766)3.93680372
56regulation of female gonad development (GO:2000194)3.93040708
57IMP biosynthetic process (GO:0006188)3.91898433
58folic acid-containing compound biosynthetic process (GO:0009396)3.91759323
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.85393965
60mitotic metaphase plate congression (GO:0007080)3.81349004
61establishment of apical/basal cell polarity (GO:0035089)3.78051625
62response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.75257658
63mitotic nuclear envelope disassembly (GO:0007077)3.75027581
64proline biosynthetic process (GO:0006561)3.74315429
65negative regulation of cardiac muscle hypertrophy (GO:0010614)3.71457141
66nucleobase biosynthetic process (GO:0046112)3.70547084
67sister chromatid segregation (GO:0000819)3.70414359
68ribosome biogenesis (GO:0042254)3.68091513
69DNA unwinding involved in DNA replication (GO:0006268)3.66036973
70ribosome assembly (GO:0042255)3.65776384
71cellular response to glucocorticoid stimulus (GO:0071385)3.64824856
72positive regulation of guanylate cyclase activity (GO:0031284)3.63246035
73regulation of relaxation of muscle (GO:1901077)3.62267021
74sarcoplasmic reticulum calcium ion transport (GO:0070296)3.59565603
75peptidyl-arginine omega-N-methylation (GO:0035247)3.59195926
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.57955292
77heterochromatin organization (GO:0070828)3.57663663
78DNA replication checkpoint (GO:0000076)3.57135844
79DNA strand elongation involved in DNA replication (GO:0006271)3.55993120
80muscle cell cellular homeostasis (GO:0046716)3.54527569
81membrane disassembly (GO:0030397)3.53168880
82nuclear envelope disassembly (GO:0051081)3.53168880
83DNA geometric change (GO:0032392)3.52911060
84striated muscle contraction (GO:0006941)3.52724847
85DNA duplex unwinding (GO:0032508)3.51940336
86sarcomere organization (GO:0045214)3.51146046
87regulation of translational termination (GO:0006449)3.49012967
88intestinal epithelial cell development (GO:0060576)3.48066381
89IMP metabolic process (GO:0046040)3.47961144
90chaperone-mediated protein complex assembly (GO:0051131)3.46824047
91pore complex assembly (GO:0046931)3.46473119
92* muscle system process (GO:0003012)3.43394274
93embryonic process involved in female pregnancy (GO:0060136)3.41744447
94negative regulation of organelle assembly (GO:1902116)3.38420938
95regulation of centrosome cycle (GO:0046605)3.36625722
96negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.35826263
97paraxial mesoderm development (GO:0048339)3.35174474
98response to testosterone (GO:0033574)3.35143139
99spliceosomal tri-snRNP complex assembly (GO:0000244)3.34930657
100cellular response to corticosteroid stimulus (GO:0071384)3.34585805
101histone H4-K5 acetylation (GO:0043981)3.33499959
102histone H4-K8 acetylation (GO:0043982)3.33499959
103* muscle contraction (GO:0006936)3.32386507
104DNA strand elongation (GO:0022616)3.29905697
105regulation of telomere maintenance via telomerase (GO:0032210)3.29217641
106pre-miRNA processing (GO:0031054)3.28206314
107establishment of monopolar cell polarity (GO:0061162)3.28077027
108establishment or maintenance of monopolar cell polarity (GO:0061339)3.28077027
109regulation of mitotic spindle organization (GO:0060236)3.27665155
110regulation of histone H3-K9 methylation (GO:0051570)3.25804430
111nodal signaling pathway (GO:0038092)3.24349784
112telomere maintenance via semi-conservative replication (GO:0032201)3.23207918
113muscle fiber development (GO:0048747)3.22367180
114regulation of guanylate cyclase activity (GO:0031282)3.21904982
115metaphase plate congression (GO:0051310)3.20250501
116regulation of DNA methylation (GO:0044030)3.19801217
117phototransduction, visible light (GO:0007603)3.18499507
118positive regulation of histone H3-K4 methylation (GO:0051571)3.17558717
119cellular response to ketone (GO:1901655)3.16737354
120regulation of centriole replication (GO:0046599)3.11282852
121negative regulation of cardiac muscle tissue development (GO:0055026)3.09676258
122DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.07584391
123regulation of gene silencing (GO:0060968)3.07176384
124replication fork processing (GO:0031297)3.06363994
125myofibril assembly (GO:0030239)3.05398886
126purine nucleobase biosynthetic process (GO:0009113)3.05392841
127DNA strand renaturation (GO:0000733)3.03247083
128negative regulation of histone methylation (GO:0031061)3.02023180
129tRNA aminoacylation for protein translation (GO:0006418)3.01839766
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01295879
131protein localization to chromosome, centromeric region (GO:0071459)3.01192174
132ribonucleoprotein complex biogenesis (GO:0022613)3.00391674
133skeletal muscle tissue development (GO:0007519)3.00319170
134mitotic G1 DNA damage checkpoint (GO:0031571)2.98705548
135regulation of SMAD protein import into nucleus (GO:0060390)2.98285195
136dosage compensation (GO:0007549)2.96984202
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.96977225
138trophectodermal cell differentiation (GO:0001829)2.93608315
139regulation of centrosome duplication (GO:0010824)2.93167355
140detection of visible light (GO:0009584)2.92904872
141mitochondrial DNA metabolic process (GO:0032042)2.92167199
142peptidyl-arginine N-methylation (GO:0035246)2.90646855
143peptidyl-arginine methylation (GO:0018216)2.90646855
144phototransduction (GO:0007602)2.88569073
145regulation of double-strand break repair (GO:2000779)2.87258497
146regulation of translation in response to stress (GO:0043555)2.86047853
147regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85750757
148DNA double-strand break processing (GO:0000729)2.85102835
149protein K6-linked ubiquitination (GO:0085020)2.84633394
150negative regulation of telomerase activity (GO:0051974)2.84295620
151negative regulation of histone acetylation (GO:0035067)2.83273087
152amino acid activation (GO:0043038)2.83227655
153tRNA aminoacylation (GO:0043039)2.83227655
154establishment of chromosome localization (GO:0051303)2.81256011
155negative regulation of DNA recombination (GO:0045910)2.80828502
156telomere maintenance via telomere lengthening (GO:0010833)2.80652844
157maturation of SSU-rRNA (GO:0030490)2.80476546
158notochord development (GO:0030903)2.79911251
159regulation of spindle organization (GO:0090224)2.79185753
160regulation of hippo signaling (GO:0035330)2.77752960
161rRNA processing (GO:0006364)2.77519718
162chromatin assembly (GO:0031497)2.77403895
163heparin biosynthetic process (GO:0030210)2.75906897
164heparin metabolic process (GO:0030202)2.75906897
165regulation of muscle system process (GO:0090257)2.75315677
166nuclear envelope organization (GO:0006998)2.75297051
167detection of light stimulus (GO:0009583)2.73822749
168embryonic placenta development (GO:0001892)2.73496615
169negative regulation of gene silencing (GO:0060969)2.73422156
170spindle assembly involved in mitosis (GO:0090307)2.73388828
171myoblast fusion (GO:0007520)2.72565124
172DNA damage response, signal transduction resulting in transcription (GO:0042772)2.71856927
173regulation of cardiac muscle cell differentiation (GO:2000725)2.69859853
174negative regulation of peptidyl-lysine acetylation (GO:2000757)2.61910955
175regulation of striated muscle contraction (GO:0006942)2.61219370
176negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.61120186
177visual perception (GO:0007601)2.60587741
178sensory perception of light stimulus (GO:0050953)2.58929485
179regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.53884825
180cardiac myofibril assembly (GO:0055003)2.51752666
181lymphangiogenesis (GO:0001946)2.50472693
182actomyosin structure organization (GO:0031032)2.47368160
183plasma membrane repair (GO:0001778)2.47142465
184regulation of muscle adaptation (GO:0043502)2.46119795
185regulation of cardiac muscle hypertrophy (GO:0010611)2.45911382
186muscle cell fate commitment (GO:0042693)2.43177835
187regulation of skeletal muscle tissue development (GO:0048641)2.41433580
188regulation of sarcomere organization (GO:0060297)2.40647690
189positive regulation of cGMP biosynthetic process (GO:0030828)2.39670628
190response to gravity (GO:0009629)12.9172336
191striated muscle atrophy (GO:0014891)12.5650329
192skeletal muscle adaptation (GO:0043501)12.5339929
193negative regulation of muscle hypertrophy (GO:0014741)11.9483654
194muscle atrophy (GO:0014889)11.1781717
195actin-myosin filament sliding (GO:0033275)10.8752799
196muscle filament sliding (GO:0030049)10.8752799
197regulation of skeletal muscle contraction (GO:0014819)10.2299650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human8.26162957
2E2F7_22180533_ChIP-Seq_HELA_Human7.39307374
3EZH2_22144423_ChIP-Seq_EOC_Human5.47288612
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.80251117
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.32707046
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.32707046
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.32707046
8AR_21572438_ChIP-Seq_LNCaP_Human4.24281896
9TAF15_26573619_Chip-Seq_HEK293_Human4.09749815
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.79959582
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.78858217
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.64890077
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.28104430
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.21912337
15MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16409307
16FOXM1_23109430_ChIP-Seq_U2OS_Human3.07357272
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.05203081
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91186199
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79202675
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.74739228
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.73494521
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66871879
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.65337359
24GBX2_23144817_ChIP-Seq_PC3_Human2.61443116
25SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.58314691
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57808680
27STAT3_1855785_ChIP-Seq_MESCs_Mouse2.53196575
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50600630
29TCF3_18692474_ChIP-Seq_MESCs_Mouse2.42258837
30* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33099616
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.30635594
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28998405
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.25173369
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.21342520
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20810368
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.20638214
37SOX2_18555785_ChIP-Seq_MESCs_Mouse2.12288248
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12250196
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10606457
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.10245968
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08873737
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07741701
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07736681
44NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.07365313
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.07153819
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.00443216
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94099880
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93285763
49FUS_26573619_Chip-Seq_HEK293_Human1.92891399
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92323812
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91297092
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91162532
53ER_23166858_ChIP-Seq_MCF-7_Human1.87194728
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86876615
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.86457906
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85394660
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.83619328
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82775808
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80181008
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.79923651
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.78243834
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77822817
63CJUN_26792858_Chip-Seq_BT549_Human1.77319669
64SMAD4_21799915_ChIP-Seq_A2780_Human1.77265092
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76744861
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76235916
67SOX2_18692474_ChIP-Seq_MEFs_Mouse1.75573579
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74692386
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.74631712
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.73009786
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.72441477
72NANOG_18692474_ChIP-Seq_MEFs_Mouse1.66715586
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61056977
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60122038
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59188454
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.58901921
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.58901921
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57295393
79XRN2_22483619_ChIP-Seq_HELA_Human1.57096235
80SOX2_18692474_ChIP-Seq_MESCs_Mouse1.55886839
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.55308035
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54366712
83NANOG_18692474_ChIP-Seq_MESCs_Mouse1.53520305
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53078987
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51756029
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48292172
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.47672181
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.47572669
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.47082400
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43780638
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42087784
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40587206
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.40534701
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39276107
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.39115824
96GATA1_22025678_ChIP-Seq_K562_Human1.38763157
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38664025
98POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.36251843
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.35571501
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.35120640
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33457519
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.33104154
103RXR_22108803_ChIP-Seq_LS180_Human1.31918521
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31005708
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30899076
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29562647
107* KDM2B_26808549_Chip-Seq_REH_Human1.28062584
108KAP1_27257070_Chip-Seq_ESCs_Mouse1.26877213
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25751851
110IRF1_19129219_ChIP-ChIP_H3396_Human1.24391725
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.23720370
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22847148
113NANOG_16518401_ChIP-PET_MESCs_Mouse1.20217398
114TTF2_22483619_ChIP-Seq_HELA_Human1.19232335
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17938539
116* STAT3_23295773_ChIP-Seq_U87_Human1.17270460
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16266102
118AR_21909140_ChIP-Seq_LNCAP_Human1.16264876
119VDR_23849224_ChIP-Seq_CD4+_Human1.15883564
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15513390
121EZH2_27304074_Chip-Seq_ESCs_Mouse1.14989554
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.14780053
123BCAT_22108803_ChIP-Seq_LS180_Human1.14252815
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13008152
125E2F1_21310950_ChIP-Seq_MCF-7_Human1.12392033
126* TCF4_23295773_ChIP-Seq_U87_Human1.11192145
127SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09476190
128* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09226606
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08484834
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08450810
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08198348
132DCP1A_22483619_ChIP-Seq_HELA_Human1.06665428
133SOX9_26525672_Chip-Seq_HEART_Mouse1.06494242
134ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06432664
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05863675
136POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05512305
137JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03975627
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02919357
139SPI1_23127762_ChIP-Seq_K562_Human1.02741524
140ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02534596
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01307374
142MYC_22102868_ChIP-Seq_BL_Human1.00340845
143GABP_19822575_ChIP-Seq_HepG2_Human1.00241334
144CEBPB_22108803_ChIP-Seq_LS180_Human0.99862634
145FOXP3_21729870_ChIP-Seq_TREG_Human0.98971691
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98641604
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.98394990
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98160172
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.98110858
150KDM5A_27292631_Chip-Seq_BREAST_Human0.98036609
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97266190
152RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96447434
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95623447
154STAT1_20625510_ChIP-Seq_HELA_Human0.95054132
155* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.94917293
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.94201424
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.94155888
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93924786
159TFEB_21752829_ChIP-Seq_HELA_Human0.91489407
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91138114
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.90958465
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90144626
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89568969
164HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89540494
165RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89055322
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88357145
167TP53_16413492_ChIP-PET_HCT116_Human0.88145864
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86821433
169NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86570940
170NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86570940
171ESR1_20079471_ChIP-ChIP_T-47D_Human0.86362241
172CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85854051
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85609980
174EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85064062
175TP63_19390658_ChIP-ChIP_HaCaT_Human0.83714326
176NANOG_16153702_ChIP-ChIP_HESCs_Human0.82415774
177* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81808924
178ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81407160
179PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80839440
180JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80468467
181SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80173187
182TP53_20018659_ChIP-ChIP_R1E_Mouse0.80116054
183CIITA_25753668_ChIP-Seq_RAJI_Human0.80086103
184ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79957087
185SA1_22415368_ChIP-Seq_MEFs_Mouse0.79646639
186SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78170562
187CBP_21632823_ChIP-Seq_H3396_Human0.78023297
188WDR5_24793694_ChIP-Seq_LNCAP_Human0.77126044
189LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75093217
190PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74286144
191PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.74221021
192SOX2_21211035_ChIP-Seq_LN229_Gbm0.73360961
193SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73251537
194TBL1_22424771_ChIP-Seq_293T_Human0.73091221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.69974478
2MP0008057_abnormal_DNA_replication5.10600408
3MP0001986_abnormal_taste_sensitivity5.01102989
4MP0005423_abnormal_somatic_nervous4.77796546
5MP0000747_muscle_weakness4.28656213
6MP0000749_muscle_degeneration4.25517828
7MP0004957_abnormal_blastocyst_morpholog4.20068959
8MP0003806_abnormal_nucleotide_metabolis4.08867620
9MP0010094_abnormal_chromosome_stability3.65983693
10MP0004036_abnormal_muscle_relaxation3.54153609
11MP0004133_heterotaxia3.52504032
12MP0003111_abnormal_nucleus_morphology3.51343032
13MP0003693_abnormal_embryo_hatching3.46326308
14MP0002653_abnormal_ependyma_morphology3.28242529
15MP0003283_abnormal_digestive_organ2.98757200
16MP0003077_abnormal_cell_cycle2.93879125
17MP0002089_abnormal_postnatal_growth/wei2.86919543
18MP0002108_abnormal_muscle_morphology2.83550396
19MP0008438_abnormal_cutaneous_collagen2.83470970
20MP0008058_abnormal_DNA_repair2.72277458
21MP0010352_gastrointestinal_tract_polyps2.71492169
22MP0004087_abnormal_muscle_fiber2.50566996
23MP0005551_abnormal_eye_electrophysiolog2.22446883
24MP0001730_embryonic_growth_arrest2.17765373
25MP0005253_abnormal_eye_physiology2.13964358
26MP0003123_paternal_imprinting2.09525170
27MP0000350_abnormal_cell_proliferation2.08917232
28MP0004264_abnormal_extraembryonic_tissu2.06222014
29MP0005620_abnormal_muscle_contractility2.02726188
30MP0003119_abnormal_digestive_system2.01892316
31MP0003890_abnormal_embryonic-extraembry1.98911708
32MP0003705_abnormal_hypodermis_morpholog1.97400848
33MP0008932_abnormal_embryonic_tissue1.88885475
34MP0000733_abnormal_muscle_development1.88117850
35MP0002085_abnormal_embryonic_tissue1.84376881
36MP0002084_abnormal_developmental_patter1.82870164
37MP0001672_abnormal_embryogenesis/_devel1.80160857
38MP0005380_embryogenesis_phenotype1.80160857
39MP0002332_abnormal_exercise_endurance1.77682655
40MP0005266_abnormal_metabolism1.76712669
41MP0005275_abnormal_skin_tensile1.73274101
42MP0003136_yellow_coat_color1.70608247
43MP0004197_abnormal_fetal_growth/weight/1.70447408
44MP0001697_abnormal_embryo_size1.68195800
45MP0003646_muscle_fatigue1.68029276
46MP0004233_abnormal_muscle_weight1.67448404
47MP0002086_abnormal_extraembryonic_tissu1.66338334
48MP0003786_premature_aging1.64112363
49MP0008007_abnormal_cellular_replicative1.62710950
50MP0003959_abnormal_lean_body1.59417673
51MP0005076_abnormal_cell_differentiation1.50990373
52MP0008877_abnormal_DNA_methylation1.49792413
53MP0004019_abnormal_vitamin_homeostasis1.48990722
54MP0005171_absent_coat_pigmentation1.48403851
55MP0003984_embryonic_growth_retardation1.47475586
56MP0005503_abnormal_tendon_morphology1.45730821
57MP0010307_abnormal_tumor_latency1.44617219
58MP0002088_abnormal_embryonic_growth/wei1.44539087
59MP0002269_muscular_atrophy1.43863365
60MP0001661_extended_life_span1.43144470
61MP0004270_analgesia1.43098699
62MP0002080_prenatal_lethality1.42989539
63MP0001348_abnormal_lacrimal_gland1.37346453
64MP0010030_abnormal_orbit_morphology1.35861831
65MP0000490_abnormal_crypts_of1.32819485
66MP0006292_abnormal_olfactory_placode1.31796107
67MP0003941_abnormal_skin_development1.27614196
68MP0000372_irregular_coat_pigmentation1.27272184
69MP0006072_abnormal_retinal_apoptosis1.24695128
70MP0003566_abnormal_cell_adhesion1.23871242
71MP0001293_anophthalmia1.23705470
72MP0002896_abnormal_bone_mineralization1.19205008
73MP0002277_abnormal_respiratory_mucosa1.18871090
74MP0003718_maternal_effect1.17550480
75MP0005623_abnormal_meninges_morphology1.17315678
76MP0009250_abnormal_appendicular_skeleto1.08853962
77MP0001145_abnormal_male_reproductive1.07376224
78MP0003950_abnormal_plasma_membrane1.05308107
79MP0006036_abnormal_mitochondrial_physio1.05094998
80MP0002210_abnormal_sex_determination1.03995976
81MP0003121_genomic_imprinting1.02634978
82MP0010368_abnormal_lymphatic_system1.02301398
83MP0000516_abnormal_urinary_system1.01597131
84MP0005367_renal/urinary_system_phenotyp1.01597131
85MP0002111_abnormal_tail_morphology1.01432373
86MP0000313_abnormal_cell_death1.01313573
87MP0002090_abnormal_vision0.98546704
88MP0003567_abnormal_fetal_cardiomyocyte0.97796822
89MP0000750_abnormal_muscle_regeneration0.96522336
90MP0004130_abnormal_muscle_cell0.96124074
91MP0000470_abnormal_stomach_morphology0.91838090
92MP0003787_abnormal_imprinting0.90017055
93MP0005394_taste/olfaction_phenotype0.89445110
94MP0005499_abnormal_olfactory_system0.89445110
95MP0002019_abnormal_tumor_incidence0.89312080
96MP0000371_diluted_coat_color0.88809747
97MP0005083_abnormal_biliary_tract0.85771983
98MP0001849_ear_inflammation0.85414225
99MP0005023_abnormal_wound_healing0.83795618
100MP0002638_abnormal_pupillary_reflex0.81839870
101MP0002127_abnormal_cardiovascular_syste0.80530830
102MP0009780_abnormal_chondrocyte_physiolo0.78052182
103MP0004134_abnormal_chest_morphology0.77442317
104MP0002106_abnormal_muscle_physiology0.75664055
105MP0001243_abnormal_dermal_layer0.75406751
106MP0000537_abnormal_urethra_morphology0.74083228
107MP0000751_myopathy0.73488017
108MP0002114_abnormal_axial_skeleton0.73293469
109MP0004484_altered_response_of0.72952539
110MP0006035_abnormal_mitochondrial_morpho0.72608929
111MP0001929_abnormal_gametogenesis0.72551453
112MP0004145_abnormal_muscle_electrophysio0.72465448
113MP0000653_abnormal_sex_gland0.71998629
114MP0005391_vision/eye_phenotype0.71444827
115MP0003936_abnormal_reproductive_system0.70935800
116MP0001324_abnormal_eye_pigmentation0.70053659
117MP0000467_abnormal_esophagus_morphology0.69820788
118MP0003045_fibrosis0.69331420
119MP0000858_altered_metastatic_potential0.68707000
120MP0002075_abnormal_coat/hair_pigmentati0.68401052
121MP0002249_abnormal_larynx_morphology0.68394650
122MP0003861_abnormal_nervous_system0.67835005
123MP0008770_decreased_survivor_rate0.66976007
124MP0000759_abnormal_skeletal_muscle0.66569914
125MP0001879_abnormal_lymphatic_vessel0.66561301
126MP0005384_cellular_phenotype0.66060515
127MP0000762_abnormal_tongue_morphology0.65871951
128MP0000358_abnormal_cell_content/0.65010170
129MP0005369_muscle_phenotype0.64772865
130MP0005621_abnormal_cell_physiology0.64507546
131MP0005508_abnormal_skeleton_morphology0.63967149
132MP0002796_impaired_skin_barrier0.63463237
133MP0002877_abnormal_melanocyte_morpholog0.63242783
134MP0000432_abnormal_head_morphology0.62996805
135MP0004084_abnormal_cardiac_muscle0.61494622
136MP0002697_abnormal_eye_size0.60548314
137MP0001286_abnormal_eye_development0.60338734
138MP0005376_homeostasis/metabolism_phenot0.59453189
139MP0002254_reproductive_system_inflammat0.59396927
140MP0000013_abnormal_adipose_tissue0.57629739
141MP0003385_abnormal_body_wall0.55015576
142MP0002060_abnormal_skin_morphology0.54911017
143MP0006054_spinal_hemorrhage0.53983379
144MP0002971_abnormal_brown_adipose0.52856175
145MP0003937_abnormal_limbs/digits/tail_de0.51994045
146MP0003091_abnormal_cell_migration0.51706482
147MP0004215_abnormal_myocardial_fiber0.51264957
148MP0003279_aneurysm0.50573217
149MP0005195_abnormal_posterior_eye0.49353790
150MP0004043_abnormal_pH_regulation0.47855434
151MP0010630_abnormal_cardiac_muscle0.46234251
152MP0002734_abnormal_mechanical_nocicepti0.45679215
153MP0005257_abnormal_intraocular_pressure0.45386737
154MP0006138_congestive_heart_failure0.44723123
155MP0002115_abnormal_skeleton_extremities0.44708203
156MP0005451_abnormal_body_composition0.43903054
157MP0005167_abnormal_blood-brain_barrier0.40714437
158MP0005452_abnormal_adipose_tissue0.39657366
159MP0001346_abnormal_lacrimal_gland0.38073908
160MP0001542_abnormal_bone_strength0.37663248
161MP0000266_abnormal_heart_morphology0.36680125
162MP0002972_abnormal_cardiac_muscle0.35924170
163MP0000566_synostosis0.35387046
164MP0002736_abnormal_nociception_after0.34992884
165MP0000427_abnormal_hair_cycle0.34964923
166MP0002095_abnormal_skin_pigmentation0.34724047
167MP0005334_abnormal_fat_pad0.34198083
168MP0002752_abnormal_somatic_nervous0.33856559
169MP0000163_abnormal_cartilage_morphology0.33154565
170MP0001299_abnormal_eye_distance/0.32600964
171MP0002160_abnormal_reproductive_system0.32529007
172MP0001544_abnormal_cardiovascular_syste0.32394674
173MP0005385_cardiovascular_system_phenoty0.32394674
174MP0001958_emphysema0.31340879
175MP0001968_abnormal_touch/_nociception0.30510007
176MP0002113_abnormal_skeleton_development0.29985711

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.59412871
2Nemaline bodies (HP:0003798)8.07000302
3Exercise-induced myalgia (HP:0003738)7.49064281
4Distal arthrogryposis (HP:0005684)7.19836483
5Palpebral edema (HP:0100540)7.01276304
6Round ear (HP:0100830)6.75857824
7Ependymoma (HP:0002888)6.05009694
8Type 1 muscle fiber predominance (HP:0003803)5.60302942
9Decreased electroretinogram (ERG) amplitude (HP:0000654)5.48255348
10Mask-like facies (HP:0000298)5.43367578
11Ulnar deviation of the wrist (HP:0003049)5.39621492
12Abnormality of the labia minora (HP:0012880)5.23247684
13Absent phalangeal crease (HP:0006109)5.22533865
14Calcaneovalgus deformity (HP:0001848)5.12708507
15Increased connective tissue (HP:0009025)4.67587078
16Astrocytoma (HP:0009592)4.58823039
17Abnormality of the astrocytes (HP:0100707)4.58823039
18Deformed tarsal bones (HP:0008119)4.53822330
19Abnormal finger flexion creases (HP:0006143)4.36028317
20Hyperkalemia (HP:0002153)4.11464774
21Myopathic facies (HP:0002058)4.11321153
22Rib fusion (HP:0000902)3.95417774
23Neoplasm of the oral cavity (HP:0100649)3.89298096
24Agnosia (HP:0010524)3.73336949
25Bony spicule pigmentary retinopathy (HP:0007737)3.71606570
26Abnormality of the salivary glands (HP:0010286)3.65499537
27Medulloblastoma (HP:0002885)3.62943216
28Fatigable weakness (HP:0003473)3.62328546
29Abnormality of the neuromuscular junction (HP:0003398)3.62328546
30Rectal fistula (HP:0100590)3.56877430
31Rectovaginal fistula (HP:0000143)3.56877430
32Rhabdomyosarcoma (HP:0002859)3.51953035
33Scotoma (HP:0000575)3.50398592
34Attenuation of retinal blood vessels (HP:0007843)3.50158099
35Aplasia/hypoplasia of the humerus (HP:0006507)3.47842897
36Breast hypoplasia (HP:0003187)3.46147834
37Glioma (HP:0009733)3.40145179
38Myoglobinuria (HP:0002913)3.38499460
39Nonprogressive disorder (HP:0003680)3.37950702
40Type 2 muscle fiber atrophy (HP:0003554)3.37124971
41Absent radius (HP:0003974)3.35819068
42Periorbital edema (HP:0100539)3.35767073
43Choroideremia (HP:0001139)3.34901582
44Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34131005
45Short humerus (HP:0005792)3.32864168
46Abnormality of the lower motor neuron (HP:0002366)3.26714907
47Facial edema (HP:0000282)3.20019834
48Abdominal situs inversus (HP:0003363)3.18977109
49Abnormality of abdominal situs (HP:0011620)3.18977109
50Chromsome breakage (HP:0040012)3.16108753
51Muscle fiber atrophy (HP:0100295)3.14789945
52Aplasia involving forearm bones (HP:0009822)3.12080259
53Absent forearm bone (HP:0003953)3.12080259
54Shawl scrotum (HP:0000049)3.11913861
55Malignant hyperthermia (HP:0002047)3.10823657
56Selective tooth agenesis (HP:0001592)3.07177549
57Intestinal fistula (HP:0100819)3.05411524
58Supernumerary spleens (HP:0009799)3.04074019
59Vaginal fistula (HP:0004320)3.01136439
60Neoplasm of striated muscle (HP:0009728)3.00342481
61Decreased central vision (HP:0007663)2.97144994
62Cortical dysplasia (HP:0002539)2.95303251
63Muscle hypertrophy of the lower extremities (HP:0008968)2.89217869
64Difficulty running (HP:0009046)2.85438651
65Abnormality of the calcaneus (HP:0008364)2.82870387
66Birth length less than 3rd percentile (HP:0003561)2.80324849
67Popliteal pterygium (HP:0009756)2.80223268
68Pigmentary retinal degeneration (HP:0001146)2.79485623
69Gowers sign (HP:0003391)2.75243175
70Myotonia (HP:0002486)2.70332842
71Central scotoma (HP:0000603)2.69296279
72Metatarsus adductus (HP:0001840)2.68984419
73Trismus (HP:0000211)2.68073483
74Increased variability in muscle fiber diameter (HP:0003557)2.67119323
75Abnormality of skeletal muscle fiber size (HP:0012084)2.56640840
76Biliary tract neoplasm (HP:0100574)2.53819075
77Hypoplastic ischia (HP:0003175)2.52889847
78Distal lower limb muscle weakness (HP:0009053)2.51791754
79Angiofibromas (HP:0010615)2.51694588
80Adenoma sebaceum (HP:0009720)2.51694588
81Basal cell carcinoma (HP:0002671)2.48027591
82Impulsivity (HP:0100710)2.47738530
83Colon cancer (HP:0003003)2.47360062
84Muscle stiffness (HP:0003552)2.46922231
85Fused cervical vertebrae (HP:0002949)2.46312222
86Posterior subcapsular cataract (HP:0007787)2.44253654
87Carpal bone hypoplasia (HP:0001498)2.43168316
88Weak cry (HP:0001612)2.43057691
89Rhabdomyolysis (HP:0003201)2.41821217
90Microglossia (HP:0000171)2.41019351
91Multiple enchondromatosis (HP:0005701)2.40788633
92Tongue fasciculations (HP:0001308)2.40723637
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34696470
94Testicular atrophy (HP:0000029)2.33346560
95Long foot (HP:0001833)2.32434779
96Absent thumb (HP:0009777)2.30975335
97Cerebral hypomyelination (HP:0006808)2.30199958
98Abnormality of the ischium (HP:0003174)2.29825915
99Abnormality of potassium homeostasis (HP:0011042)2.25144874
100Patellar aplasia (HP:0006443)2.25113401
101Muscle fibrillation (HP:0010546)2.24357092
102Abnormality of the calf musculature (HP:0001430)2.23401258
103Oral leukoplakia (HP:0002745)2.22106477
104Vertebral clefting (HP:0008428)2.17946626
105Neck muscle weakness (HP:0000467)2.17560596
106Abnormal number of incisors (HP:0011064)2.16935960
107Abnormality of the ileum (HP:0001549)2.14470660
108Aplasia/Hypoplasia of the uvula (HP:0010293)2.14013489
109Vertebral fusion (HP:0002948)2.13232947
110Generalized muscle weakness (HP:0003324)2.12242906
111Keratoconus (HP:0000563)2.11889998
112Increased corneal curvature (HP:0100692)2.11889998
113Meckel diverticulum (HP:0002245)2.11776926
114Reduced subcutaneous adipose tissue (HP:0003758)2.10537826
115Oligomenorrhea (HP:0000876)2.10536597
116Esophageal atresia (HP:0002032)2.10201109
117Delayed puberty (HP:0000823)2.10058170
118Missing ribs (HP:0000921)2.09487669
119Spastic diplegia (HP:0001264)2.06079618
120Stenosis of the external auditory canal (HP:0000402)2.05890999
121Hypoplasia of the iris (HP:0007676)2.05469072
122Amaurosis fugax (HP:0100576)2.05166258
123Abnormality of the preputium (HP:0100587)2.03264028
124Exercise-induced muscle cramps (HP:0003710)2.03248627
125Hyporeflexia of lower limbs (HP:0002600)2.01216169
126Bilateral microphthalmos (HP:0007633)2.00930027
127Bulbar palsy (HP:0001283)2.00862964
128Long clavicles (HP:0000890)2.00703763
129Bell-shaped thorax (HP:0001591)2.00487687
130Wrist flexion contracture (HP:0001239)1.98093406
131Aplasia of the musculature (HP:0100854)1.97370544
132Gastrointestinal carcinoma (HP:0002672)1.97097029
133Malignant gastrointestinal tract tumors (HP:0006749)1.97097029
134Aplasia/Hypoplasia of the patella (HP:0006498)1.96886043
135Maternal diabetes (HP:0009800)1.96392692
136Muscle fiber inclusion bodies (HP:0100299)1.95100988
137Muscle fiber splitting (HP:0003555)1.94952933
138Subcapsular cataract (HP:0000523)1.94851013
139Hypochromic microcytic anemia (HP:0004840)1.93715878
140Duplicated collecting system (HP:0000081)1.93292893
141Easy fatigability (HP:0003388)1.92977958
142Neoplasm of the colon (HP:0100273)1.91080292
143Rough bone trabeculation (HP:0100670)1.90409037
144EMG: myopathic abnormalities (HP:0003458)1.88917298
145Calf muscle hypertrophy (HP:0008981)1.88329482
146Hip contracture (HP:0003273)1.87548342
147Premature ovarian failure (HP:0008209)1.86696138
148Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86235785
149Upper limb muscle weakness (HP:0003484)1.84707551
150Abnormality of the labia (HP:0000058)1.84053198
151Supernumerary bones of the axial skeleton (HP:0009144)1.83142771
152Breech presentation (HP:0001623)1.81059231
153Muscular dystrophy (HP:0003560)1.79728831
154Neoplasm of the rectum (HP:0100743)1.77998685
155Neoplasm of the pancreas (HP:0002894)1.77746145
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77018123
157Action tremor (HP:0002345)1.75256332
158Neoplasm of the heart (HP:0100544)1.73816341
159Amniotic constriction ring (HP:0009775)1.73060742
160Abnormality of placental membranes (HP:0011409)1.73060742
161Spinal muscular atrophy (HP:0007269)1.72608867
162Progressive muscle weakness (HP:0003323)1.72325731
163Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71337127
164Sloping forehead (HP:0000340)1.71014883
165Shoulder girdle muscle weakness (HP:0003547)1.70592203
166Hypogonadotrophic hypogonadism (HP:0000044)1.70203035
167Ovarian neoplasm (HP:0100615)1.69731062
168Orthostatic hypotension (HP:0001278)1.69578633
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.69287429
170Areflexia of lower limbs (HP:0002522)1.69183076
171Nephroblastoma (Wilms tumor) (HP:0002667)1.67797943
172Abnormality of the anterior horn cell (HP:0006802)1.67542484
173Degeneration of anterior horn cells (HP:0002398)1.67542484
174Rectal prolapse (HP:0002035)1.67419036
175Abnormality of chromosome stability (HP:0003220)1.67008767
176Premature graying of hair (HP:0002216)1.66924603
177Tracheoesophageal fistula (HP:0002575)1.66816877
178Fetal akinesia sequence (HP:0001989)1.63208477
179Toxemia of pregnancy (HP:0100603)1.59660512
180Abnormality of the left ventricular outflow tract (HP:0011103)1.58659813
181Subaortic stenosis (HP:0001682)1.58659813
182Ulnar claw (HP:0001178)1.57206958
183Type II diabetes mellitus (HP:0005978)1.56252400
184Abnormality of macular pigmentation (HP:0008002)1.55237398
185Hypoplastic iliac wings (HP:0002866)1.55046205
186Limited hip movement (HP:0008800)1.54304842
187Decreased circulating renin level (HP:0003351)1.48737780
188Polar cataract (HP:0010696)1.47888982
189Aortic aneurysm (HP:0004942)1.47599600
190Down-sloping shoulders (HP:0200021)1.46814177
191Macular degeneration (HP:0000608)1.44692556
192Urethral obstruction (HP:0000796)1.43411667
193Mesomelia (HP:0003027)1.41667870
194Abnormal pupillary function (HP:0007686)1.41151463
195Congenital hip dislocation (HP:0001374)1.40328429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK6.06736748
2GRK15.71781758
3PHKG24.76753499
4PHKG14.76753499
5CDK124.50444222
6NEK14.21940475
7AKT33.95942500
8WEE13.67411178
9EPHA23.62946986
10TIE13.54277435
11WNK43.13112720
12TTK2.71874328
13RPS6KB22.67515081
14PIK3CG2.63860532
15MAPKAPK32.53147897
16CDC72.38084979
17TSSK62.30195264
18WNK12.27539122
19PDK22.05470759
20PLK12.02421708
21NEK21.97684924
22BCKDK1.92141805
23PNCK1.90420792
24EIF2AK11.89856270
25TRPM71.88099567
26PDK31.86795997
27PDK41.86795997
28CDK71.78727452
29BUB11.76008685
30CAMK1D1.71265012
31LATS21.54806916
32CAMK1G1.48211071
33FRK1.47786707
34TAOK21.46865286
35IRAK11.43367707
36ICK1.41220789
37JAK31.39347150
38MOS1.38544076
39OBSCN1.37439080
40TYRO31.35134449
41MAPK131.33098501
42STK391.30256528
43SCYL21.29704707
44CHEK21.29597850
45MST41.29589808
46PAK41.22668535
47PRKD21.22400639
48ATR1.22051623
49ILK1.21977555
50CAMKK21.21898208
51STK38L1.20892915
52CHEK11.18250526
53MATK1.17362181
54ALK1.17084235
55PRKD31.15742718
56DAPK11.14649607
57PLK31.14373910
58DDR21.12837659
59PIK3CA1.12477056
60LIMK11.11618683
61CAMK2G1.07855796
62AURKA1.06410702
63CDK41.05697197
64MAP3K81.02776751
65TRIB31.00987968
66SRPK11.00616646
67DYRK31.00209813
68EIF2AK30.98752873
69BRD40.98268388
70PRKCI0.95272128
71AURKB0.94975312
72PTK2B0.93816459
73CCNB10.93121800
74MET0.93077404
75MARK30.92343227
76CDK20.89097922
77ERN10.88529341
78MAP3K120.88336738
79STK100.86886804
80ATM0.84184660
81PASK0.83763837
82GRK50.83267765
83ARAF0.81457745
84CSNK1E0.80810894
85PAK60.78555494
86MYLK0.78348495
87BCR0.75866476
88TESK20.75857011
89YES10.75583910
90DMPK0.75396784
91PINK10.72072222
92MTOR0.71508807
93AKT20.71273586
94LMTK20.71053892
95TTN0.68920876
96CSNK2A20.66433323
97PLK40.66382967
98PIM10.65454638
99MAP3K110.65128109
100DYRK20.65038771
101MAPK120.63292860
102NME10.62622726
103CSK0.62252956
104CDK10.58460367
105CSNK1D0.57481640
106GRK60.57423201
107MAPK70.56847157
108BMX0.56319689
109ADRBK10.56028230
110IRAK30.55810053
111STK40.52807846
112MAP3K90.52408634
113PRKG10.50774081
114ADRBK20.50424276
115NUAK10.48976366
116PRPF4B0.47484857
117PRKAA20.47313118
118MAP2K10.46863165
119WNK30.46544262
120STK380.45538211
121FLT30.45043833
122MARK20.44589884
123CSNK2A10.43106048
124CDK60.42939012
125MAP3K60.42406415
126PTK20.41616143
127FGR0.41563790
128MAPK140.41217112
129PKN10.41023300
130PAK20.40538079
131TEC0.40390860
132MAPK150.40232560
133PRKDC0.39774104
134RAF10.39679617
135MAPK100.39336663
136BRSK20.38475168
137EIF2AK20.37891032
138CAMK40.36852158
139PAK10.36404164
140SGK10.35775767
141MAP2K30.35275436
142GSK3B0.34941903
143LATS10.34635529
144PDGFRB0.34415931
145ABL20.34119471
146MAPK10.33771664
147STK30.33633455
148GSK3A0.32755000
149MAPK110.31543035
150BRAF0.30888290
151PLK20.29871222
152PDPK10.27614937
153CDC42BPA0.27546018
154PDGFRA0.27370877
155MAP2K20.26874498
156CAMK10.26649155
157PRKD10.25554333
158FER0.23912981
159PRKACB0.23210511
160MELK0.23189207
161CDK90.20562258
162VRK20.20413229
163RPS6KA30.18824238
164ROCK10.17920413
165MAP3K70.17199231
166NME20.12784953
167TLK10.12116471
168EEF2K0.11356143
169PRKACA0.09657969
170MAPKAPK50.09240686
171DYRK1B0.08614513

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.90183896
2Mismatch repair_Homo sapiens_hsa034304.83264891
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14554274
4DNA replication_Homo sapiens_hsa030304.07643200
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.46214866
6RNA transport_Homo sapiens_hsa030133.22499922
7One carbon pool by folate_Homo sapiens_hsa006703.21914089
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.96668822
9Base excision repair_Homo sapiens_hsa034102.82824223
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.77863565
11Spliceosome_Homo sapiens_hsa030402.74656834
12Dilated cardiomyopathy_Homo sapiens_hsa054142.68083200
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.62243344
14Proteasome_Homo sapiens_hsa030502.40747211
15Nucleotide excision repair_Homo sapiens_hsa034202.30994749
16RNA polymerase_Homo sapiens_hsa030202.25420136
17Regulation of autophagy_Homo sapiens_hsa041402.25192885
18Ribosome_Homo sapiens_hsa030102.20282117
19Biosynthesis of amino acids_Homo sapiens_hsa012302.13233823
20Homologous recombination_Homo sapiens_hsa034402.13203352
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12904914
22Fanconi anemia pathway_Homo sapiens_hsa034602.04284316
23Calcium signaling pathway_Homo sapiens_hsa040202.00530172
24Oxytocin signaling pathway_Homo sapiens_hsa049211.93345003
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.85062640
26Cell cycle_Homo sapiens_hsa041101.80851283
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74723821
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70961884
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.70777879
30Nitrogen metabolism_Homo sapiens_hsa009101.66631976
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61078917
32Circadian rhythm_Homo sapiens_hsa047101.57731056
33mRNA surveillance pathway_Homo sapiens_hsa030151.54413211
34Fructose and mannose metabolism_Homo sapiens_hsa000511.48985050
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.45246972
36RNA degradation_Homo sapiens_hsa030181.41353844
37Gastric acid secretion_Homo sapiens_hsa049711.40936965
38Folate biosynthesis_Homo sapiens_hsa007901.38761576
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38561166
40Circadian entrainment_Homo sapiens_hsa047131.36872398
41Focal adhesion_Homo sapiens_hsa045101.36467490
42Carbon metabolism_Homo sapiens_hsa012001.33210303
43Platelet activation_Homo sapiens_hsa046111.32826569
44Pyrimidine metabolism_Homo sapiens_hsa002401.29345217
45p53 signaling pathway_Homo sapiens_hsa041151.28718188
46Non-homologous end-joining_Homo sapiens_hsa034501.28240759
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24700299
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24559719
49Olfactory transduction_Homo sapiens_hsa047401.21031082
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17726602
51ABC transporters_Homo sapiens_hsa020101.17457710
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15670938
53Basal transcription factors_Homo sapiens_hsa030221.13222306
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12676033
55Renin secretion_Homo sapiens_hsa049241.12549917
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12479609
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09630804
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07046693
59ECM-receptor interaction_Homo sapiens_hsa045121.02062030
60Hippo signaling pathway_Homo sapiens_hsa043901.01426908
61Arginine and proline metabolism_Homo sapiens_hsa003301.00762896
62Morphine addiction_Homo sapiens_hsa050320.98907659
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98322756
64Basal cell carcinoma_Homo sapiens_hsa052170.94853745
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94304097
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91067261
67Epstein-Barr virus infection_Homo sapiens_hsa051690.89425738
68Glioma_Homo sapiens_hsa052140.88854589
69Oocyte meiosis_Homo sapiens_hsa041140.88499848
70Cholinergic synapse_Homo sapiens_hsa047250.86937466
71Long-term potentiation_Homo sapiens_hsa047200.85538577
72Long-term depression_Homo sapiens_hsa047300.84200289
73Amoebiasis_Homo sapiens_hsa051460.82064103
74mTOR signaling pathway_Homo sapiens_hsa041500.80311180
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79730805
76Huntingtons disease_Homo sapiens_hsa050160.76941535
77* Tight junction_Homo sapiens_hsa045300.76531426
78Insulin secretion_Homo sapiens_hsa049110.75614874
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75205664
80Pyruvate metabolism_Homo sapiens_hsa006200.72579693
81Pentose phosphate pathway_Homo sapiens_hsa000300.71556551
82GABAergic synapse_Homo sapiens_hsa047270.70309892
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69736976
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69041195
85Selenocompound metabolism_Homo sapiens_hsa004500.68512215
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68226217
87Serotonergic synapse_Homo sapiens_hsa047260.67925002
88Oxidative phosphorylation_Homo sapiens_hsa001900.67646002
89Pancreatic secretion_Homo sapiens_hsa049720.64333496
90Notch signaling pathway_Homo sapiens_hsa043300.62700958
91ErbB signaling pathway_Homo sapiens_hsa040120.61453841
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61235466
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60910746
94MAPK signaling pathway_Homo sapiens_hsa040100.59611547
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59320606
96Ovarian steroidogenesis_Homo sapiens_hsa049130.59214406
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57754354
98Bile secretion_Homo sapiens_hsa049760.57682699
99Viral carcinogenesis_Homo sapiens_hsa052030.56577204
100Purine metabolism_Homo sapiens_hsa002300.55567977
101Ras signaling pathway_Homo sapiens_hsa040140.55470312
102Dopaminergic synapse_Homo sapiens_hsa047280.55133161
103Hedgehog signaling pathway_Homo sapiens_hsa043400.54358593
104Cardiac muscle contraction_Homo sapiens_hsa042600.53994220
105Mineral absorption_Homo sapiens_hsa049780.53653734
106GnRH signaling pathway_Homo sapiens_hsa049120.53316447
107TGF-beta signaling pathway_Homo sapiens_hsa043500.52737871
108Proteoglycans in cancer_Homo sapiens_hsa052050.51905510
109Taste transduction_Homo sapiens_hsa047420.51677200
110Galactose metabolism_Homo sapiens_hsa000520.51656148
111Insulin signaling pathway_Homo sapiens_hsa049100.51594729
112Salivary secretion_Homo sapiens_hsa049700.50834444
113Retinol metabolism_Homo sapiens_hsa008300.50547299
114Insulin resistance_Homo sapiens_hsa049310.50096320
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50028741
116Gap junction_Homo sapiens_hsa045400.49617223
117Dorso-ventral axis formation_Homo sapiens_hsa043200.49317526
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49216304
119Protein digestion and absorption_Homo sapiens_hsa049740.49071384
120Colorectal cancer_Homo sapiens_hsa052100.48752299
121Glutathione metabolism_Homo sapiens_hsa004800.46063582
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.45158837
123Fat digestion and absorption_Homo sapiens_hsa049750.44818754
124Parkinsons disease_Homo sapiens_hsa050120.44305485
125Collecting duct acid secretion_Homo sapiens_hsa049660.44177703
126Small cell lung cancer_Homo sapiens_hsa052220.42716488
127Thyroid cancer_Homo sapiens_hsa052160.42448461
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42290117
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41885945
130cAMP signaling pathway_Homo sapiens_hsa040240.40874274
131Bladder cancer_Homo sapiens_hsa052190.38854632
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38003430
133MicroRNAs in cancer_Homo sapiens_hsa052060.37733263
134Estrogen signaling pathway_Homo sapiens_hsa049150.36632980
135Arginine biosynthesis_Homo sapiens_hsa002200.35359674
136VEGF signaling pathway_Homo sapiens_hsa043700.32699327
137Vitamin B6 metabolism_Homo sapiens_hsa007500.32268078
138Adherens junction_Homo sapiens_hsa045200.31906246
139Lysine degradation_Homo sapiens_hsa003100.31064966
140Endocytosis_Homo sapiens_hsa041440.30545616
141Synaptic vesicle cycle_Homo sapiens_hsa047210.29953185
142Prostate cancer_Homo sapiens_hsa052150.28759632
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.28703766
144HTLV-I infection_Homo sapiens_hsa051660.27894182
145Pathways in cancer_Homo sapiens_hsa052000.27049284
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26982920
147HIF-1 signaling pathway_Homo sapiens_hsa040660.26791334
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26487445
149Linoleic acid metabolism_Homo sapiens_hsa005910.24803261
150Metabolic pathways_Homo sapiens_hsa011000.22899623
151Wnt signaling pathway_Homo sapiens_hsa043100.22668762
152Legionellosis_Homo sapiens_hsa051340.22655437
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21955670
154Arachidonic acid metabolism_Homo sapiens_hsa005900.20927808
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.19976084
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19155428
157Antigen processing and presentation_Homo sapiens_hsa046120.17753780
158Herpes simplex infection_Homo sapiens_hsa051680.17244867
159Vibrio cholerae infection_Homo sapiens_hsa051100.17190910
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16782252
161Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16476132
162Glucagon signaling pathway_Homo sapiens_hsa049220.16370745
163Fatty acid biosynthesis_Homo sapiens_hsa000610.13751259
164Renin-angiotensin system_Homo sapiens_hsa046140.13267952
165AMPK signaling pathway_Homo sapiens_hsa041520.12674199
166Systemic lupus erythematosus_Homo sapiens_hsa053220.12673337
167Alzheimers disease_Homo sapiens_hsa050100.10984830
168Melanoma_Homo sapiens_hsa052180.10644907
169Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10044851

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