MYH14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)6.24331769
2intestinal absorption (GO:0050892)5.41866205
3intestinal cholesterol absorption (GO:0030299)5.15886730
4surfactant homeostasis (GO:0043129)4.97479501
5angiotensin maturation (GO:0002003)4.96134952
6desmosome organization (GO:0002934)4.64748962
7hemidesmosome assembly (GO:0031581)4.52130422
8ventricular cardiac muscle cell action potential (GO:0086005)4.20545973
9chemical homeostasis within a tissue (GO:0048875)4.15474616
10cell communication involved in cardiac conduction (GO:0086065)3.99927239
11virion attachment to host cell (GO:0019062)3.94370192
12adhesion of symbiont to host cell (GO:0044650)3.94370192
13epoxygenase P450 pathway (GO:0019373)3.93882212
14flavonoid metabolic process (GO:0009812)3.83606984
15axonemal dynein complex assembly (GO:0070286)3.78691243
16primary alcohol catabolic process (GO:0034310)3.76627068
17vitamin transmembrane transport (GO:0035461)3.68987073
18drug catabolic process (GO:0042737)3.68081987
19regulation of water loss via skin (GO:0033561)3.66095211
20vitamin A metabolic process (GO:0006776)3.55244550
21regulation of bile acid biosynthetic process (GO:0070857)3.55150580
22hormone catabolic process (GO:0042447)3.54831993
23actin filament depolymerization (GO:0030042)3.43741651
24positive regulation of Cdc42 GTPase activity (GO:0043089)3.43308849
25intestinal epithelial cell development (GO:0060576)3.42832345
26regulation of cholesterol homeostasis (GO:2000188)3.41726436
27water homeostasis (GO:0030104)3.41615486
28regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.41481219
29positive regulation of fatty acid beta-oxidation (GO:0032000)3.39298755
30fructose metabolic process (GO:0006000)3.36637331
31maintenance of gastrointestinal epithelium (GO:0030277)3.34284072
32cellular glucuronidation (GO:0052695)3.28132913
33sulfate transmembrane transport (GO:1902358)3.26165959
34urea cycle (GO:0000050)3.25173664
35establishment of skin barrier (GO:0061436)3.22599373
36sarcomere organization (GO:0045214)3.19054035
37adhesion of symbiont to host (GO:0044406)3.18334131
38urea metabolic process (GO:0019627)3.16347856
39cardiac conduction (GO:0061337)3.16223988
40epithelial cell-cell adhesion (GO:0090136)3.14265452
41regulation of heart rate by cardiac conduction (GO:0086091)3.13612770
42regulation of guanylate cyclase activity (GO:0031282)3.12739728
43renal system process involved in regulation of blood volume (GO:0001977)3.10571035
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10430603
45phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.09937458
46regulation of cholesterol metabolic process (GO:0090181)3.08738267
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.08525953
48uronic acid metabolic process (GO:0006063)3.08266062
49glucuronate metabolic process (GO:0019585)3.08266062
50bile acid and bile salt transport (GO:0015721)3.08158808
51digestive system process (GO:0022600)3.03266565
52membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.02527771
53regulation of cholesterol biosynthetic process (GO:0045540)2.97587229
54bicarbonate transport (GO:0015701)2.97533186
55epithelial structure maintenance (GO:0010669)2.96696897
56sodium ion export (GO:0071436)2.96503078
57glomerular filtration (GO:0003094)2.95694255
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95563741
59UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95174318
60motile cilium assembly (GO:0044458)2.95004176
61cilium or flagellum-dependent cell motility (GO:0001539)2.94297637
62regulation of p38MAPK cascade (GO:1900744)2.93151260
63membrane repolarization during action potential (GO:0086011)2.92251462
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90436688
65renal filtration (GO:0097205)2.90008526
66peptidyl-tyrosine autophosphorylation (GO:0038083)2.89013592
67nitrogen cycle metabolic process (GO:0071941)2.86101055
68lung epithelium development (GO:0060428)2.84147779
69auditory receptor cell differentiation (GO:0042491)2.83968132
70regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83689460
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.83655700
72relaxation of cardiac muscle (GO:0055119)2.83178086
73regulation of cardioblast differentiation (GO:0051890)2.83114430
74exogenous drug catabolic process (GO:0042738)2.81787801
75branching involved in mammary gland duct morphogenesis (GO:0060444)2.80701956
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.79885450
773-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.79885450
78regulation of fatty acid beta-oxidation (GO:0031998)2.79093001
79regulation of triglyceride catabolic process (GO:0010896)2.75197584
80activation of Rac GTPase activity (GO:0032863)2.73295735
81positive regulation of p38MAPK cascade (GO:1900745)2.73039123
82receptor guanylyl cyclase signaling pathway (GO:0007168)2.72993802
83regulation of systemic arterial blood pressure by hormone (GO:0001990)2.72526186
84regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.72526186
85endocrine process (GO:0050886)2.72526186
86transcytosis (GO:0045056)2.72105286
87positive regulation of lipid catabolic process (GO:0050996)2.71523205
88O-glycan processing (GO:0016266)2.71078654
89peptide catabolic process (GO:0043171)2.70756375
90cardiac muscle cell action potential involved in contraction (GO:0086002)2.67096427
91negative regulation of potassium ion transmembrane transport (GO:1901380)2.65164395
92regulation of pseudopodium assembly (GO:0031272)2.62903710
93renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.62596999
94cardiac muscle cell action potential (GO:0086001)2.57884570
95regulation of systemic arterial blood pressure (GO:0003073)2.57653586
96sperm capacitation (GO:0048240)2.57419649
97positive regulation of pseudopodium assembly (GO:0031274)2.56700360
98cell communication by electrical coupling (GO:0010644)2.56047898
99positive regulation of fatty acid oxidation (GO:0046321)2.55894355
100myelin maintenance (GO:0043217)2.55097339
101regulation of glucose import in response to insulin stimulus (GO:2001273)2.54370900
102negative regulation of myotube differentiation (GO:0010832)2.51589136
103positive regulation of respiratory burst (GO:0060267)2.51381789
104ethanol metabolic process (GO:0006067)2.51366396
105amino-acid betaine transport (GO:0015838)2.51141452
106carnitine transport (GO:0015879)2.51141452
107phosphate ion transmembrane transport (GO:0035435)2.49994890
108macroautophagy (GO:0016236)2.49359835
109receptor recycling (GO:0001881)2.49196583
110gap junction assembly (GO:0016264)2.49107335
111phospholipid homeostasis (GO:0055091)2.48185702
112regulation of viral release from host cell (GO:1902186)2.47034937
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.46875265
114NADH metabolic process (GO:0006734)2.46231433
115cellular potassium ion homeostasis (GO:0030007)2.45971510
116glutamine family amino acid biosynthetic process (GO:0009084)2.45303192
117carnitine transmembrane transport (GO:1902603)2.45149143
118sulfate transport (GO:0008272)2.44604589
119positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44373303
120cholesterol homeostasis (GO:0042632)2.43062750
121establishment of apical/basal cell polarity (GO:0035089)2.43015129
122phospholipid efflux (GO:0033700)2.42726941
123negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42002867
124tight junction assembly (GO:0070830)2.41748594
125sterol homeostasis (GO:0055092)2.41581491
126diacylglycerol metabolic process (GO:0046339)2.40519689
127fat-soluble vitamin biosynthetic process (GO:0042362)2.40358791
128calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.40086104
129carnitine shuttle (GO:0006853)2.39605924
130primary alcohol metabolic process (GO:0034308)2.39481573
131sodium ion homeostasis (GO:0055078)2.38529541
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.37717350
133sulfur amino acid catabolic process (GO:0000098)2.37665944
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36500328
135multicellular organismal water homeostasis (GO:0050891)2.36430342
136positive regulation of lipoprotein lipase activity (GO:0051006)2.36365602
137positive regulation of triglyceride lipase activity (GO:0061365)2.36365602
138response to food (GO:0032094)2.36234184
139glutathione biosynthetic process (GO:0006750)2.36182944
140regulation of actin filament-based movement (GO:1903115)2.35900788
141glucose 6-phosphate metabolic process (GO:0051156)2.35169153
142cell-cell junction maintenance (GO:0045217)2.34683639
143neurotransmitter biosynthetic process (GO:0042136)2.34217168
144potassium ion import (GO:0010107)2.33616304
145phenylpropanoid metabolic process (GO:0009698)2.32327664
146lipoprotein metabolic process (GO:0042157)2.31032583
147positive regulation of fatty acid biosynthetic process (GO:0045723)2.29886841
148cellular sodium ion homeostasis (GO:0006883)2.28618678
149regulation of skeletal muscle contraction (GO:0014819)2.27838791
150cardiac muscle contraction (GO:0060048)2.25133295
151tricarboxylic acid cycle (GO:0006099)2.24766548
152fatty acid transmembrane transport (GO:1902001)2.24660869
153drug metabolic process (GO:0017144)2.24323378
154membrane repolarization (GO:0086009)2.23550743
155plasma membrane repair (GO:0001778)2.23479826
156positive regulation of triglyceride metabolic process (GO:0090208)2.23455911
157transepithelial transport (GO:0070633)2.23355193
158* actomyosin structure organization (GO:0031032)2.22394894
159renal absorption (GO:0070293)2.21322348
160cholesterol efflux (GO:0033344)2.21162711
161protein localization to endosome (GO:0036010)2.20757584
162ethanol oxidation (GO:0006069)2.20697686
163intermediate filament organization (GO:0045109)2.19088784
164sulfur compound transport (GO:0072348)2.18729764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.10528492
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.03458961
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95555658
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67327786
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.48402627
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45425518
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.42689414
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.24162960
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.11689499
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10239926
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.06776620
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05229371
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05092789
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.00093379
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95734395
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.94866804
17ZNF263_19887448_ChIP-Seq_K562_Human1.85047521
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81872122
19GATA4_25053715_ChIP-Seq_YYC3_Human1.80434740
20* SOX2_20726797_ChIP-Seq_SW620_Human1.78981560
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72319719
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69202921
23GATA6_25053715_ChIP-Seq_YYC3_Human1.66005589
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63571185
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60000272
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.59852126
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.56750179
28CLOCK_20551151_ChIP-Seq_293T_Human1.54523624
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.53509983
30SMC4_20622854_ChIP-Seq_HELA_Human1.51451242
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49631793
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48220798
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46551616
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.40521962
35* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40169865
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39914215
37* DROSHA_22980978_ChIP-Seq_HELA_Human1.37408224
38GATA1_22025678_ChIP-Seq_K562_Human1.36364699
39* KLF5_25053715_ChIP-Seq_YYC3_Human1.36094220
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36017001
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.33960085
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33858635
43P68_20966046_ChIP-Seq_HELA_Human1.30148349
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.29559378
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.29559378
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28434922
47LXR_22292898_ChIP-Seq_THP-1_Human1.27772501
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27506622
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26746637
50AHR_22903824_ChIP-Seq_MCF-7_Human1.25079463
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24985057
52* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23904571
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.23076856
54TCF7_22412390_ChIP-Seq_EML_Mouse1.21981486
55* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21308520
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21016417
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19917519
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18936055
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.18071013
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16952748
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16330236
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16122449
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15447864
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14107297
65* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13186624
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13136600
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.12776806
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12745302
69KDM2B_26808549_Chip-Seq_K562_Human1.12048161
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11627674
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10342529
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09379546
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08234251
74* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08123758
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07415113
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07120476
77* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06957015
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06762152
79* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06708864
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06149543
81CTCF_27219007_Chip-Seq_Bcells_Human1.03912820
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03873171
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03193935
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02653773
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.02541925
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01941723
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01349249
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01117206
89* ATF3_27146783_Chip-Seq_COLON_Human1.00551290
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99040165
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99028326
92GATA2_19941826_ChIP-Seq_K562_Human0.98578817
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98541430
94* CREB1_26743006_Chip-Seq_LNCaP_Human0.97584476
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.97520920
96* BCOR_27268052_Chip-Seq_Bcells_Human0.97397982
97TP63_22573176_ChIP-Seq_HFKS_Human0.97352755
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97007943
99SA1_27219007_Chip-Seq_Bcells_Human0.96154884
100GATA1_19941826_ChIP-Seq_K562_Human0.95626538
101RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95552506
102* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93825341
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.93563574
104JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93520433
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93422034
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92656827
107EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92444047
108RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92444047
109CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91811330
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91803623
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91760862
112KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91757257
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.91465625
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91180074
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90755757
116IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90578428
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.90486361
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90379955
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90379955
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.90362761
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.90260623
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90184551
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89903107
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89839912
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89783755
126SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89231849
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89109611
128EZH2_27294783_Chip-Seq_ESCs_Mouse0.88789613
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87467049
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86660297
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85999387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.71223777
2MP0005360_urolithiasis4.64095352
3MP0001666_abnormal_nutrient_absorption3.75819966
4MP0004264_abnormal_extraembryonic_tissu2.96243297
5MP0005085_abnormal_gallbladder_physiolo2.81224593
6MP0002139_abnormal_hepatobiliary_system2.76350750
7MP0008875_abnormal_xenobiotic_pharmacok2.75300661
8MP0004782_abnormal_surfactant_physiolog2.72043580
9MP0003705_abnormal_hypodermis_morpholog2.38046389
10MP0005409_darkened_coat_color2.36959814
11MP0000462_abnormal_digestive_system2.34404936
12MP0002796_impaired_skin_barrier2.34063394
13MP0005167_abnormal_blood-brain_barrier2.24079731
14MP0009840_abnormal_foam_cell2.22809904
15MP0000537_abnormal_urethra_morphology2.17770539
16MP0005451_abnormal_body_composition2.17053074
17MP0003252_abnormal_bile_duct2.12835808
18MP0002837_dystrophic_cardiac_calcinosis2.10751173
19MP0002822_catalepsy2.05737178
20MP0003866_abnormal_defecation2.04897837
21MP0009379_abnormal_foot_pigmentation1.99542079
22MP0005670_abnormal_white_adipose1.99391964
23MP0000678_abnormal_parathyroid_gland1.92119917
24MP0005365_abnormal_bile_salt1.89177301
25MP0010329_abnormal_lipoprotein_level1.82844048
26MP0000751_myopathy1.80264776
27MP0008004_abnormal_stomach_pH1.74842459
28MP0003191_abnormal_cellular_cholesterol1.74616442
29MP0004084_abnormal_cardiac_muscle1.74549234
30MP0002249_abnormal_larynx_morphology1.73389999
31MP0004043_abnormal_pH_regulation1.71073793
32MP0010678_abnormal_skin_adnexa1.68812535
33MP0005083_abnormal_biliary_tract1.67814829
34MP0003283_abnormal_digestive_organ1.67037640
35MP0003878_abnormal_ear_physiology1.64475680
36MP0005377_hearing/vestibular/ear_phenot1.64475680
37MP0005076_abnormal_cell_differentiation1.60593179
38MP0001664_abnormal_digestion1.58972546
39MP0003879_abnormal_hair_cell1.56098355
40MP0001849_ear_inflammation1.50961629
41MP0003300_gastrointestinal_ulcer1.50736209
42MP0004215_abnormal_myocardial_fiber1.45488038
43MP0001958_emphysema1.45257915
44MP0000579_abnormal_nail_morphology1.42373472
45MP0002098_abnormal_vibrissa_morphology1.41432842
46MP0002138_abnormal_hepatobiliary_system1.40447574
47MP0002234_abnormal_pharynx_morphology1.35656811
48MP0004036_abnormal_muscle_relaxation1.33297549
49MP0005381_digestive/alimentary_phenotyp1.32111839
50MP0009780_abnormal_chondrocyte_physiolo1.31509170
51MP0006138_congestive_heart_failure1.26337111
52MP0002909_abnormal_adrenal_gland1.25173888
53MP0001663_abnormal_digestive_system1.24592525
54MP0003566_abnormal_cell_adhesion1.21839857
55MP0001765_abnormal_ion_homeostasis1.21126908
56MP0005501_abnormal_skin_physiology1.21047315
57MP0004019_abnormal_vitamin_homeostasis1.17536117
58MP0010352_gastrointestinal_tract_polyps1.17284149
59MP0000467_abnormal_esophagus_morphology1.16721780
60MP0003646_muscle_fatigue1.16475602
61MP0005330_cardiomyopathy1.15519246
62MP0004484_altered_response_of1.15514488
63MP0003868_abnormal_feces_composition1.15130162
64MP0009643_abnormal_urine_homeostasis1.15116232
65MP0000377_abnormal_hair_follicle1.15049825
66MP0004270_analgesia1.13937708
67MP0002254_reproductive_system_inflammat1.12293836
68MP0003453_abnormal_keratinocyte_physiol1.12246821
69MP0000538_abnormal_urinary_bladder1.11886548
70MP0002118_abnormal_lipid_homeostasis1.10635313
71MP0003183_abnormal_peptide_metabolism1.10281522
72MP0010155_abnormal_intestine_physiology1.10207270
73MP0002972_abnormal_cardiac_muscle1.05822165
74MP0005375_adipose_tissue_phenotype1.05771904
75MP0003045_fibrosis1.05074873
76MP0005275_abnormal_skin_tensile1.04874493
77MP0004185_abnormal_adipocyte_glucose1.04506103
78MP0010368_abnormal_lymphatic_system1.03874794
79MP0000477_abnormal_intestine_morphology1.03655959
80MP0002876_abnormal_thyroid_physiology1.03392711
81MP0000566_synostosis1.01532414
82MP0004087_abnormal_muscle_fiber0.99391546
83MP0002896_abnormal_bone_mineralization0.96389019
84MP0010771_integument_phenotype0.94394489
85MP0003806_abnormal_nucleotide_metabolis0.93701551
86MP0000749_muscle_degeneration0.93573647
87MP0000747_muscle_weakness0.93462316
88MP0002971_abnormal_brown_adipose0.92132512
89MP0005636_abnormal_mineral_homeostasis0.91727598
90MP0001544_abnormal_cardiovascular_syste0.91458346
91MP0005385_cardiovascular_system_phenoty0.91458346
92MP0004130_abnormal_muscle_cell0.90512891
93MP0006054_spinal_hemorrhage0.90439424
94MP0004858_abnormal_nervous_system0.89750919
95MP0005166_decreased_susceptibility_to0.89595072
96MP0003329_amyloid_beta_deposits0.86653463
97MP0000003_abnormal_adipose_tissue0.85676384
98MP0003950_abnormal_plasma_membrane0.84208567
99MP0000383_abnormal_hair_follicle0.83223981
100MP0001873_stomach_inflammation0.82329448
101MP0005332_abnormal_amino_acid0.81564828
102MP0003123_paternal_imprinting0.80983703
103MP0005620_abnormal_muscle_contractility0.80680390
104MP0001216_abnormal_epidermal_layer0.80567136
105MP0004147_increased_porphyrin_level0.78650039
106MP0003137_abnormal_impulse_conducting0.78391909
107MP0008775_abnormal_heart_ventricle0.77626135
108MP0002136_abnormal_kidney_physiology0.77296544
109MP0005666_abnormal_adipose_tissue0.77203554
110MP0010630_abnormal_cardiac_muscle0.77011594
111MP0001485_abnormal_pinna_reflex0.76612459
112MP0005084_abnormal_gallbladder_morpholo0.76489526
113MP0008961_abnormal_basal_metabolism0.76473414
114MP0004085_abnormal_heartbeat0.74958799
115MP0001756_abnormal_urination0.74890303
116MP0009384_cardiac_valve_regurgitation0.73935863
117MP0005023_abnormal_wound_healing0.73618118
118MP0002060_abnormal_skin_morphology0.73400360
119MP0005058_abnormal_lysosome_morphology0.73205143
120MP0004272_abnormal_basement_membrane0.72372183
121MP0000762_abnormal_tongue_morphology0.72165234
122MP0004947_skin_inflammation0.70506945
123MP0000470_abnormal_stomach_morphology0.69069336
124MP0002133_abnormal_respiratory_system0.68733194
125MP0005388_respiratory_system_phenotype0.68733194
126MP0005319_abnormal_enzyme/_coenzyme0.68710300
127MP0005165_increased_susceptibility_to0.66718812
128MP0009931_abnormal_skin_appearance0.65125262
129MP0003638_abnormal_response/metabolism_0.62951119
130MP0000013_abnormal_adipose_tissue0.62735684
131MP0000609_abnormal_liver_physiology0.60565906
132MP0000490_abnormal_crypts_of0.59708039
133MP0004145_abnormal_muscle_electrophysio0.59211877
134MP0005448_abnormal_energy_balance0.57722202
135MP0000681_abnormal_thyroid_gland0.56204063
136MP0002089_abnormal_postnatal_growth/wei0.55190881

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.09671026
2Ileus (HP:0002595)4.94296232
3Hyperactive renin-angiotensin system (HP:0000841)4.91595456
4Ventricular tachycardia (HP:0004756)4.16775138
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.98156124
6Interstitial pulmonary disease (HP:0006530)3.95749340
7Syncope (HP:0001279)3.94540899
8Bundle branch block (HP:0011710)3.72372955
9Sudden death (HP:0001699)3.69533397
10Ventricular fibrillation (HP:0001663)3.67616870
11Chronic bronchitis (HP:0004469)3.62422539
12Onycholysis (HP:0001806)3.46313568
13Milia (HP:0001056)3.42301995
14Malnutrition (HP:0004395)3.32871194
15Hemorrhage of the eye (HP:0011885)3.32667891
16Palpitations (HP:0001962)3.25449219
17Abnormal respiratory motile cilium morphology (HP:0005938)3.22099995
18Abnormal respiratory epithelium morphology (HP:0012253)3.22099995
19Abnormal respiratory motile cilium physiology (HP:0012261)3.18252125
20Distal lower limb amyotrophy (HP:0008944)3.17687035
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13929841
22Nasal polyposis (HP:0100582)3.13471098
23Rhinitis (HP:0012384)3.07851958
24Polycythemia (HP:0001901)3.06972217
25Abnormal ciliary motility (HP:0012262)3.06776482
26Hyporeflexia of lower limbs (HP:0002600)3.04164782
27Fragile nails (HP:0001808)3.03925882
28Pili torti (HP:0003777)3.03428547
29Abnormality of chloride homeostasis (HP:0011422)3.00152951
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.98155329
31Absent/shortened dynein arms (HP:0200106)2.98155329
32Abnormality of the nasal mucosa (HP:0000433)2.97355403
33Prolonged QT interval (HP:0001657)2.90256380
34Ventricular arrhythmia (HP:0004308)2.88806215
35Myopathic facies (HP:0002058)2.85110929
36Abnormal hair laboratory examination (HP:0003328)2.84450913
37Plantar hyperkeratosis (HP:0007556)2.77985126
38Flat acetabular roof (HP:0003180)2.73895599
39Gout (HP:0001997)2.73345517
40Woolly hair (HP:0002224)2.69138310
41Atrophic scars (HP:0001075)2.68206467
42Exercise-induced myalgia (HP:0003738)2.67062335
43Abnormality of renin-angiotensin system (HP:0000847)2.63738583
44Abdominal distention (HP:0003270)2.61466513
45Distal upper limb amyotrophy (HP:0007149)2.60605411
46Upper limb amyotrophy (HP:0009129)2.60605411
47Bronchiectasis (HP:0002110)2.59471188
48Hydroxyprolinuria (HP:0003080)2.59333910
49Abnormality of proline metabolism (HP:0010907)2.59333910
50Heart block (HP:0012722)2.57187814
51Increased connective tissue (HP:0009025)2.54604540
52Potter facies (HP:0002009)2.54175824
53Facial shape deformation (HP:0011334)2.54175824
54Dehydration (HP:0001944)2.53898505
55Hyperaldosteronism (HP:0000859)2.51776661
56Abnormal atrioventricular conduction (HP:0005150)2.49417059
57Myoglobinuria (HP:0002913)2.46630407
58Rectal prolapse (HP:0002035)2.43836133
59Stridor (HP:0010307)2.41901266
60Muscle fiber splitting (HP:0003555)2.40419112
61Abnormality of the gastric mucosa (HP:0004295)2.38848700
62Hyperkalemia (HP:0002153)2.37980674
63Hyperphosphatemia (HP:0002905)2.36489006
64Widely patent fontanelles and sutures (HP:0004492)2.32040692
65Conjugated hyperbilirubinemia (HP:0002908)2.31366167
66Decreased circulating renin level (HP:0003351)2.30885943
67Esophageal varix (HP:0002040)2.30866638
68Thin bony cortex (HP:0002753)2.30111788
69Hypobetalipoproteinemia (HP:0003563)2.28788489
70Atrial fibrillation (HP:0005110)2.28053855
71Visceral angiomatosis (HP:0100761)2.26225080
72Hyperparathyroidism (HP:0000843)2.24335662
73Alopecia of scalp (HP:0002293)2.22897929
74Exercise-induced muscle cramps (HP:0003710)2.21798855
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.21503879
76Obstructive sleep apnea (HP:0002870)2.20654093
77Systemic lupus erythematosus (HP:0002725)2.20635906
78Intrahepatic cholestasis (HP:0001406)2.20473102
79Tachypnea (HP:0002789)2.18704647
80Curly hair (HP:0002212)2.15643347
81Fat malabsorption (HP:0002630)2.14271181
82Hyponatremia (HP:0002902)2.14227975
83Alkalosis (HP:0001948)2.12981330
84Broad metatarsal (HP:0001783)2.12114477
85Cupped ribs (HP:0000887)2.10901595
86Acanthocytosis (HP:0001927)2.10076394
87Primary atrial arrhythmia (HP:0001692)2.09943662
88Bronchomalacia (HP:0002780)2.07213923
89Broad face (HP:0000283)2.06678743
90Bulbar palsy (HP:0001283)2.06377788
91Muscle fiber inclusion bodies (HP:0100299)2.05477530
92Hyperglycinuria (HP:0003108)2.04050723
93Difficulty running (HP:0009046)2.03525138
94Goiter (HP:0000853)2.02690366
95Abnormality of the 1st metacarpal (HP:0010009)2.02649122
96Hemangiomatosis (HP:0007461)2.02190260
97Abnormality of purine metabolism (HP:0004352)2.01906187
98Respiratory distress (HP:0002098)2.01688506
99Growth hormone excess (HP:0000845)2.00306702
100Acanthosis nigricans (HP:0000956)2.00258633
101Lipoatrophy (HP:0100578)1.98763665
102Ankle clonus (HP:0011448)1.98105868
103Complement deficiency (HP:0004431)1.98085821
104Renal salt wasting (HP:0000127)1.97640147
105Abnormality of complement system (HP:0005339)1.97369164
106J-shaped sella turcica (HP:0002680)1.97187592
107Metabolic alkalosis (HP:0200114)1.96547934
108Lower limb amyotrophy (HP:0007210)1.96361653
109Atelectasis (HP:0100750)1.94976132
110Supraventricular tachycardia (HP:0004755)1.94135094
111Type 1 muscle fiber predominance (HP:0003803)1.93033910
112Dilated cardiomyopathy (HP:0001644)1.92813560
113Supraventricular arrhythmia (HP:0005115)1.92753365
114Hypoplasia of dental enamel (HP:0006297)1.92674964
115Neck muscle weakness (HP:0000467)1.92641061
116Abnormal EKG (HP:0003115)1.92539459
117Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.92478032
118Axonal loss (HP:0003447)1.92361123
119Fragile skin (HP:0001030)1.92116724
120Popliteal pterygium (HP:0009756)1.92026933
121Germ cell neoplasia (HP:0100728)1.91551534
122Calf muscle hypertrophy (HP:0008981)1.91351303
123Round ear (HP:0100830)1.90553941
124Pigmentary retinal degeneration (HP:0001146)1.90356465
125Xanthomatosis (HP:0000991)1.90289439
126Easy fatigability (HP:0003388)1.90269497
127Nemaline bodies (HP:0003798)1.90160270
128Ketoacidosis (HP:0001993)1.89416557
129Abnormality of potassium homeostasis (HP:0011042)1.89365992
130Abnormality of vitamin metabolism (HP:0100508)1.87296403
131Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86557632
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.86310200
133Hypotension (HP:0002615)1.85726712
134* Mildly elevated creatine phosphokinase (HP:0008180)1.85294801
135Gastrointestinal dysmotility (HP:0002579)1.83900063
136Atrioventricular block (HP:0001678)1.83387651
137Advanced eruption of teeth (HP:0006288)1.82982300
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82727813
139Hyperuricemia (HP:0002149)1.82257970
140Increased purine levels (HP:0004368)1.82257970
141Hypolipoproteinemia (HP:0010981)1.81149367
142Abnormality of the distal phalanges of the toes (HP:0010182)1.80140548
143Congenital sensorineural hearing impairment (HP:0008527)1.79791272
144Hypoglycemic coma (HP:0001325)1.79515752
145Late onset (HP:0003584)1.79455181
146Adrenal overactivity (HP:0002717)1.78543641
147Palmoplantar keratoderma (HP:0000982)1.76467534
148Vascular calcification (HP:0004934)1.76019611
149Muscle hypertrophy of the lower extremities (HP:0008968)1.75457173
150EMG: myopathic abnormalities (HP:0003458)1.75152795
151Palmoplantar hyperkeratosis (HP:0000972)1.74902990
152Sudden cardiac death (HP:0001645)1.74525611
153Focal segmental glomerulosclerosis (HP:0000097)1.74433582
154Abnormality of small intestinal villus morphology (HP:0011472)1.73212071
155Villous atrophy (HP:0011473)1.73212071
156Glomerulosclerosis (HP:0000096)1.72613733
157Distal lower limb muscle weakness (HP:0009053)1.72319268
158Abnormality of the calf musculature (HP:0001430)1.71599331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.82530872
2RIPK13.65495501
3MST42.95524608
4FRK2.92258780
5MST1R2.92189364
6EPHA22.63383755
7PIK3CA2.21546255
8EPHB22.16150911
9MYLK2.05589568
10SMG12.03743159
11MAP3K22.02567455
12MAP2K22.00662035
13PRKG22.00295281
14EPHB11.96617707
15PTK61.92530527
16TTN1.89626913
17EEF2K1.84753058
18TRIB31.84089119
19FER1.77996190
20IRAK31.76979943
21DMPK1.75549926
22TIE11.70922565
23DDR21.68008260
24ERN11.64690917
25NME11.55920428
26KSR21.41349664
27PHKG11.41010190
28PHKG21.41010190
29TAOK11.38046892
30MAP3K71.25142046
31MUSK1.23922511
32RPS6KB21.23699548
33MET1.20376063
34PTK21.18435144
35TAOK31.16568405
36LATS11.12280038
37PAK41.11350205
38PDGFRA1.11329758
39SIK11.06915516
40MAP3K91.06867081
41PKN21.06834547
42MAP3K11.04482440
43ACVR1B1.04259705
44ICK1.03328623
45LRRK21.02469967
46MATK0.99176617
47STK240.98337864
48MAP3K30.98058063
49WNK40.96961416
50FGFR40.95412006
51ERBB20.93992284
52PAK30.91112780
53TESK10.87811550
54GRK60.86582037
55MAP2K10.86516094
56FGFR20.85006560
57PDPK10.83808035
58PRKD10.81079865
59CDC42BPA0.78881575
60CAMK2D0.77706746
61NEK60.77257817
62OBSCN0.76896936
63PDK40.76595896
64PDK30.76595896
65AKT30.75560921
66PRPF4B0.75467686
67PRKAA20.68290525
68ROCK10.68193594
69DAPK20.68140098
70TGFBR20.68080701
71BMX0.68054463
72FGFR30.67462350
73STK100.67026214
74MAP3K100.66537740
75PDGFRB0.66157772
76MTOR0.66137525
77MAPK150.65952895
78MAP2K60.64169962
79MARK20.64097338
80TYRO30.64007774
81MAPK110.63101876
82OXSR10.62701740
83PRKCI0.62687716
84EPHA30.61927650
85IRAK20.59751094
86STK390.59382132
87TRPM70.58126154
88RPS6KA20.57413887
89CAMK2B0.57270158
90WNK10.56067865
91PRKAA10.55787836
92INSRR0.55288511
93PDK20.54762183
94SGK30.54736935
95NEK10.53709448
96PRKD20.53567232
97MAPKAPK30.53528011
98STK380.49805534
99NTRK10.49353928
100MAP3K110.47991843
101RET0.47900212
102CDK120.47225047
103PRKD30.47076239
104ROCK20.46999971
105IRAK10.46800745
106DYRK1B0.45800160
107CAMK2G0.45715973
108TBK10.45246765
109PINK10.44950536
110STK38L0.44439974
111SCYL20.43451559
112MAP3K60.43019307
113DAPK30.41813262
114CHUK0.41280999
115PDK10.40020771
116GSK3A0.39700571
117GRK10.39552087
118ILK0.38012575
119HIPK20.36421144
120CSK0.36169011
121SRC0.35657989
122MAP2K30.35342191
123LIMK10.34648317
124LATS20.34361501
125BCKDK0.34208434
126MAP3K80.33573104
127EPHA40.30394337
128MAPKAPK20.26933350
129AKT20.25424870
130RPS6KL10.23231376
131RPS6KC10.23231376
132MAPK120.22223307
133MAP3K120.21660278

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.24793071
2Mineral absorption_Homo sapiens_hsa049783.05731179
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.88144428
4Sulfur metabolism_Homo sapiens_hsa009202.66185993
5Bile secretion_Homo sapiens_hsa049762.26960310
6Renin-angiotensin system_Homo sapiens_hsa046142.13133661
7Caffeine metabolism_Homo sapiens_hsa002322.04258400
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.03238340
9Fatty acid degradation_Homo sapiens_hsa000711.86642818
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86531612
11Starch and sucrose metabolism_Homo sapiens_hsa005001.70876565
12Nitrogen metabolism_Homo sapiens_hsa009101.69755943
13Galactose metabolism_Homo sapiens_hsa000521.61875706
14Tryptophan metabolism_Homo sapiens_hsa003801.59889902
15Vitamin digestion and absorption_Homo sapiens_hsa049771.59302404
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57941304
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56076217
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54606584
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53578625
20Histidine metabolism_Homo sapiens_hsa003401.52651586
21Tyrosine metabolism_Homo sapiens_hsa003501.49549637
22PPAR signaling pathway_Homo sapiens_hsa033201.44858084
23Protein digestion and absorption_Homo sapiens_hsa049741.43474567
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30161511
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.28897584
26Arginine biosynthesis_Homo sapiens_hsa002201.26954744
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23341240
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.23280351
29Fructose and mannose metabolism_Homo sapiens_hsa000511.19809920
30Linoleic acid metabolism_Homo sapiens_hsa005911.19340964
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19077403
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18411912
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17507084
34Fatty acid metabolism_Homo sapiens_hsa012121.16773315
35* Tight junction_Homo sapiens_hsa045301.15677237
36Gastric acid secretion_Homo sapiens_hsa049711.12474193
37Pancreatic secretion_Homo sapiens_hsa049721.04539433
38Glycerolipid metabolism_Homo sapiens_hsa005611.03951094
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03936978
40Dilated cardiomyopathy_Homo sapiens_hsa054141.03581728
41Butanoate metabolism_Homo sapiens_hsa006501.00335257
42Propanoate metabolism_Homo sapiens_hsa006401.00058443
43Salivary secretion_Homo sapiens_hsa049700.98478188
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96808344
45ABC transporters_Homo sapiens_hsa020100.93148187
46Adherens junction_Homo sapiens_hsa045200.92397326
47Carbon metabolism_Homo sapiens_hsa012000.91150093
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91148488
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89010136
50AMPK signaling pathway_Homo sapiens_hsa041520.88657418
51Arachidonic acid metabolism_Homo sapiens_hsa005900.88141097
52Pyruvate metabolism_Homo sapiens_hsa006200.87852880
53Thyroid hormone synthesis_Homo sapiens_hsa049180.87050709
54Fatty acid biosynthesis_Homo sapiens_hsa000610.86949105
55beta-Alanine metabolism_Homo sapiens_hsa004100.86678332
56Glucagon signaling pathway_Homo sapiens_hsa049220.86268060
57Cardiac muscle contraction_Homo sapiens_hsa042600.86068001
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85647723
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82663090
60Glutathione metabolism_Homo sapiens_hsa004800.80079235
61Pentose phosphate pathway_Homo sapiens_hsa000300.79599843
62Chemical carcinogenesis_Homo sapiens_hsa052040.77950035
63Notch signaling pathway_Homo sapiens_hsa043300.74610380
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73696255
65Arginine and proline metabolism_Homo sapiens_hsa003300.72832234
66Other glycan degradation_Homo sapiens_hsa005110.72026932
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71335102
68Renin secretion_Homo sapiens_hsa049240.70655800
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68910003
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68088890
71Bladder cancer_Homo sapiens_hsa052190.68040101
72Type II diabetes mellitus_Homo sapiens_hsa049300.67346399
73Insulin secretion_Homo sapiens_hsa049110.64025561
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.62498415
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.62333365
76Insulin resistance_Homo sapiens_hsa049310.60369972
77ECM-receptor interaction_Homo sapiens_hsa045120.59209664
78Hepatitis C_Homo sapiens_hsa051600.58995516
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58256622
80Phenylalanine metabolism_Homo sapiens_hsa003600.56949610
81Folate biosynthesis_Homo sapiens_hsa007900.54469609
82Biosynthesis of amino acids_Homo sapiens_hsa012300.53679105
83Sulfur relay system_Homo sapiens_hsa041220.52360452
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.51887817
85Sphingolipid metabolism_Homo sapiens_hsa006000.51563063
86Fatty acid elongation_Homo sapiens_hsa000620.51545018
87Amoebiasis_Homo sapiens_hsa051460.50180666
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49968296
89Dorso-ventral axis formation_Homo sapiens_hsa043200.49120648
90GnRH signaling pathway_Homo sapiens_hsa049120.47653434
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.45538990
92Retinol metabolism_Homo sapiens_hsa008300.45453840
93Complement and coagulation cascades_Homo sapiens_hsa046100.45360800
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44695035
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44442385
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44049159
97Thyroid cancer_Homo sapiens_hsa052160.42981695
98Focal adhesion_Homo sapiens_hsa045100.42802986
99Peroxisome_Homo sapiens_hsa041460.42593624
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42591935
101Vibrio cholerae infection_Homo sapiens_hsa051100.42548387
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42503185
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.41412783
104Choline metabolism in cancer_Homo sapiens_hsa052310.40203247
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38213030
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36062316
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35154849
108Gap junction_Homo sapiens_hsa045400.35126172
109Inositol phosphate metabolism_Homo sapiens_hsa005620.35091910
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34945593
111Taste transduction_Homo sapiens_hsa047420.34689872
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33794526
113Insulin signaling pathway_Homo sapiens_hsa049100.33055977
114VEGF signaling pathway_Homo sapiens_hsa043700.32872572
115Lysine degradation_Homo sapiens_hsa003100.32650594
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32411687
117Endometrial cancer_Homo sapiens_hsa052130.31469672
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30958142
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.28910541
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.28311890
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.27618758
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27404294
123Ether lipid metabolism_Homo sapiens_hsa005650.27392958

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