MYH15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-chromophore linkage (GO:0018298)9.58780142
2cellular response to electrical stimulus (GO:0071257)9.06050822
3retinol metabolic process (GO:0042572)8.60140309
4cell wall macromolecule catabolic process (GO:0016998)8.18599895
5cell wall macromolecule metabolic process (GO:0044036)8.18599895
6fusion of sperm to egg plasma membrane (GO:0007342)7.95000727
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)7.81086079
8positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)7.23739503
9multicellular organism reproduction (GO:0032504)7.00123563
10fat-soluble vitamin metabolic process (GO:0006775)6.70000871
11detection of light stimulus involved in visual perception (GO:0050908)6.16258997
12detection of light stimulus involved in sensory perception (GO:0050962)6.16258997
13plasma membrane fusion (GO:0045026)6.07141380
14acrosome assembly (GO:0001675)6.02269950
15cilium or flagellum-dependent cell motility (GO:0001539)5.97869957
16reproduction (GO:0000003)5.95861404
17mitotic cytokinesis (GO:0000281)5.80707648
18sperm motility (GO:0030317)5.71423428
19tyrosine metabolic process (GO:0006570)5.67344274
20regulation of rhodopsin mediated signaling pathway (GO:0022400)5.61034988
21cytoskeleton-dependent cytokinesis (GO:0061640)5.59264803
22sperm-egg recognition (GO:0035036)5.44075820
23primary alcohol metabolic process (GO:0034308)5.42815146
24positive regulation of Rho protein signal transduction (GO:0035025)5.38684621
25mitotic metaphase plate congression (GO:0007080)5.38392328
26cytokinetic process (GO:0032506)5.25014050
27rhodopsin mediated signaling pathway (GO:0016056)5.22639741
28piRNA metabolic process (GO:0034587)5.15564506
29mitotic chromosome condensation (GO:0007076)4.98749751
30retinoic acid metabolic process (GO:0042573)4.98328695
31acrosome reaction (GO:0007340)4.98031616
32cell-cell recognition (GO:0009988)4.91403859
33epithelial cilium movement (GO:0003351)4.81400031
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.67456099
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.67456099
36positive regulation of mitotic sister chromatid separation (GO:1901970)4.67456099
37male meiosis (GO:0007140)4.65758485
38spermatid development (GO:0007286)4.53577313
39protein localization to chromosome, centromeric region (GO:0071459)4.48183435
40microtubule depolymerization (GO:0007019)4.45708790
41motile cilium assembly (GO:0044458)4.41500115
42axonemal dynein complex assembly (GO:0070286)4.37179492
43positive regulation of cytokinesis (GO:0032467)4.33424864
44mitotic sister chromatid cohesion (GO:0007064)4.32397301
45binding of sperm to zona pellucida (GO:0007339)4.30789436
46positive regulation of DNA-templated transcription, elongation (GO:0032786)4.29944284
47camera-type eye morphogenesis (GO:0048593)4.29700472
48apoptotic DNA fragmentation (GO:0006309)4.28666981
49metaphase plate congression (GO:0051310)4.28005476
50peptidyl-threonine dephosphorylation (GO:0035970)4.19016877
51sensory perception of smell (GO:0007608)4.16260846
52keratinocyte proliferation (GO:0043616)4.11769977
53single fertilization (GO:0007338)4.10995383
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.02760972
55regulation of spindle organization (GO:0090224)3.98963096
56replicative senescence (GO:0090399)3.97691071
57protein localization to chromosome (GO:0034502)3.96026320
58cilium movement (GO:0003341)3.96007062
59regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.95657605
60G-protein coupled receptor internalization (GO:0002031)3.92880503
61phenol-containing compound biosynthetic process (GO:0046189)3.90893590
62positive regulation of chromosome segregation (GO:0051984)3.89851279
63regulation of mitotic spindle organization (GO:0060236)3.86281122
64positive regulation of guanylate cyclase activity (GO:0031284)3.85824827
65sulfate transport (GO:0008272)3.84927648
66regulation of double-strand break repair via homologous recombination (GO:0010569)3.84353586
67bicarbonate transport (GO:0015701)3.84319079
687-methylguanosine mRNA capping (GO:0006370)3.83612556
69phototransduction (GO:0007602)3.73191920
70detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.72441893
71RNA capping (GO:0036260)3.70905309
727-methylguanosine RNA capping (GO:0009452)3.70905309
73N-terminal protein amino acid acetylation (GO:0006474)3.69890398
74positive regulation of histone acetylation (GO:0035066)3.69649898
75secondary metabolic process (GO:0019748)3.69050514
76synaptonemal complex organization (GO:0070193)3.63361477
77neuroblast proliferation (GO:0007405)3.63038487
78synaptonemal complex assembly (GO:0007130)3.60818598
79stress fiber assembly (GO:0043149)3.54286490
80mitochondrion distribution (GO:0048311)3.54084481
81retinoid metabolic process (GO:0001523)3.49642686
82detection of light stimulus (GO:0009583)3.49371787
83melanocyte differentiation (GO:0030318)3.49234020
84diterpenoid biosynthetic process (GO:0016102)3.49116395
85establishment of chromosome localization (GO:0051303)3.45878706
86regulation of guanylate cyclase activity (GO:0031282)3.45826270
87microtubule polymerization or depolymerization (GO:0031109)3.38624125
88retina homeostasis (GO:0001895)3.37425949
89fertilization (GO:0009566)3.36323094
90DNA methylation involved in gamete generation (GO:0043046)3.34715215
91somatic stem cell division (GO:0048103)3.33965048
92protein localization to kinetochore (GO:0034501)3.33912222
93sister chromatid cohesion (GO:0007062)3.33452756
94diterpenoid metabolic process (GO:0016101)3.29532106
95cellular aldehyde metabolic process (GO:0006081)3.28039364
96phototransduction, visible light (GO:0007603)3.27241446
97sperm capacitation (GO:0048240)3.26540036
98retinal rod cell development (GO:0046548)3.21254969
99nuclear pore complex assembly (GO:0051292)3.20510210
100female gamete generation (GO:0007292)3.13852361
101regulation of cilium movement (GO:0003352)3.13141325
102positive regulation of protein acetylation (GO:1901985)3.10859437
103positive regulation of peptidyl-lysine acetylation (GO:2000758)3.10859437
104DNA synthesis involved in DNA repair (GO:0000731)3.10569231
105ear development (GO:0043583)3.10416642
106sensory perception of chemical stimulus (GO:0007606)3.09559281
107positive regulation of muscle cell apoptotic process (GO:0010661)3.09160438
108meiotic cell cycle (GO:0051321)3.07755363
109ketone body metabolic process (GO:1902224)3.06610621
110mitotic sister chromatid segregation (GO:0000070)3.06207623
111pigment cell differentiation (GO:0050931)3.03485993
112gene silencing by RNA (GO:0031047)3.02088473
113negative regulation of inclusion body assembly (GO:0090084)3.01759891
114regulation of cytokinesis (GO:0032465)3.01362147
115terpenoid metabolic process (GO:0006721)3.00819471
116vitamin A metabolic process (GO:0006776)27.0062243
117detection of chemical stimulus involved in sensory perception (GO:0050907)2.98844113
118detection of visible light (GO:0009584)2.94062883
119visual perception (GO:0007601)2.92661230
120mRNA cleavage (GO:0006379)2.91296365
121synapsis (GO:0007129)2.90631096
122sensory perception of light stimulus (GO:0050953)2.88274827
123regulation of double-strand break repair (GO:2000779)2.86037357
124nuclear pore organization (GO:0006999)2.84578375
125response to electrical stimulus (GO:0051602)2.84383486
126negative regulation of interleukin-8 production (GO:0032717)2.83973075
127spermatogenesis (GO:0007283)2.82068202
128male meiosis I (GO:0007141)2.81489979
129histone phosphorylation (GO:0016572)2.81339706
130male gamete generation (GO:0048232)2.80165870
131histone-serine phosphorylation (GO:0035404)2.80027844
132regulation of nucleobase-containing compound transport (GO:0032239)2.79851293
133chromosome organization involved in meiosis (GO:0070192)2.77842495
134regulation of chromosome segregation (GO:0051983)2.75952138
135N-terminal protein amino acid modification (GO:0031365)2.75492294
136calcium ion-dependent exocytosis (GO:0017156)2.75312499
137positive regulation of viral transcription (GO:0050434)2.75044739
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.74375385
139cell recognition (GO:0008037)2.74275469
140sister chromatid segregation (GO:0000819)2.73008252
141organic cation transport (GO:0015695)2.72454281
142regulation of DNA methylation (GO:0044030)2.71787109
143spermatid nucleus differentiation (GO:0007289)2.70917399
144cellular process involved in reproduction in multicellular organism (GO:0022412)2.70310222
145actin filament bundle organization (GO:0061572)2.70056476
146actin filament bundle assembly (GO:0051017)2.70056476
147retinal cone cell development (GO:0046549)2.69406638
148ventricular system development (GO:0021591)2.69080463
149negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.66302022
150gamete generation (GO:0007276)2.65110734
151cytokinesis (GO:0000910)2.64332249
152detection of external stimulus (GO:0009581)2.63275004
153microtubule severing (GO:0051013)2.62939327
154chromosome condensation (GO:0030261)2.62290544
155regulation of DNA-templated transcription, elongation (GO:0032784)2.62069644
156germ cell development (GO:0007281)2.61719778
157coronary vasculature morphogenesis (GO:0060977)2.61210608
158bone remodeling (GO:0046849)2.58594718
159detection of abiotic stimulus (GO:0009582)2.57643892
160skin morphogenesis (GO:0043589)2.57336924
161cellular hormone metabolic process (GO:0034754)2.56336978
162arachidonic acid secretion (GO:0050482)2.55813934
163icosanoid secretion (GO:0032309)2.55813934
164ribosome assembly (GO:0042255)2.54423195
165SMAD protein complex assembly (GO:0007183)2.54284899
166regulation of inclusion body assembly (GO:0090083)2.52643753
167peripheral nervous system axon ensheathment (GO:0032292)2.49496421
168myelination in peripheral nervous system (GO:0022011)2.49496421
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42870533
170branch elongation of an epithelium (GO:0060602)2.40539701
171positive regulation of neuroblast proliferation (GO:0002052)2.38869278
172negative regulation of hormone metabolic process (GO:0032351)2.35596694
173negative regulation of hormone biosynthetic process (GO:0032353)2.35596694
174neuroepithelial cell differentiation (GO:0060563)2.35571818
175ovulation cycle (GO:0042698)2.33931120
176genitalia morphogenesis (GO:0035112)2.31607598
177isoprenoid metabolic process (GO:0006720)2.31084675
178sexual reproduction (GO:0019953)2.30943850
179monoubiquitinated protein deubiquitination (GO:0035520)2.29812248
180response to pheromone (GO:0019236)2.29738190
181phosphatidylinositol acyl-chain remodeling (GO:0036149)2.25351210
182meiotic nuclear division (GO:0007126)2.23316399
183melanin biosynthetic process (GO:0042438)12.2526939
184retinal metabolic process (GO:0042574)11.3951315
185melanin metabolic process (GO:0006582)11.0363691
186secondary metabolite biosynthetic process (GO:0044550)10.1538055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.81842630
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.34019845
3E2F7_22180533_ChIP-Seq_HELA_Human5.04390442
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14224509
5AR_21909140_ChIP-Seq_LNCAP_Human3.13112677
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08186718
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79973191
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66516707
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46681560
10EZH2_22144423_ChIP-Seq_EOC_Human2.34023125
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33528826
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28509958
13TP53_16413492_ChIP-PET_HCT116_Human2.27621763
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.23636923
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.22101855
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19733580
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17108972
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.16250549
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.13171871
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08503755
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06448628
22CTNNB1_20460455_ChIP-Seq_HCT116_Human2.05468296
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90535269
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.90229516
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89633305
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84641159
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77614105
28MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71746345
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70611016
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68828783
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67148110
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67148110
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67148110
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58005658
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55147037
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54218949
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54183788
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47338633
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47025708
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45722045
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45363356
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.45358953
43KDM2B_26808549_Chip-Seq_REH_Human1.42691334
44CMYC_18555785_Chip-Seq_ESCs_Mouse1.42153160
45SMAD4_21799915_ChIP-Seq_A2780_Human1.37494067
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37328065
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37328065
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37185274
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36226754
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35003189
51GBX2_23144817_ChIP-Seq_PC3_Human1.34761122
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33787668
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33610313
54BRD4_25478319_ChIP-Seq_HGPS_Human1.33514709
55TBL1_22424771_ChIP-Seq_293T_Human1.32879035
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32648840
57* TAL1_26923725_Chip-Seq_HPCs_Mouse1.31719946
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.31700077
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30876165
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30373601
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30255930
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29625670
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29415327
64* STAT3_23295773_ChIP-Seq_U87_Human1.29239150
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28590601
66TAF15_26573619_Chip-Seq_HEK293_Human1.28129130
67TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.27937203
68P53_22387025_ChIP-Seq_ESCs_Mouse1.27675830
69* AR_25329375_ChIP-Seq_VCAP_Human1.27467834
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27021120
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26453331
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.26350318
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26181009
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26117460
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25422131
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25237533
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23088820
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23088820
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22967415
80AR_21572438_ChIP-Seq_LNCaP_Human1.22935329
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22898437
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.22694402
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22443236
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.21245315
85P300_19829295_ChIP-Seq_ESCs_Human1.20920009
86CBP_21632823_ChIP-Seq_H3396_Human1.20562188
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19998779
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.19783249
89NFYB_21822215_ChIP-Seq_K562_Human1.19756061
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19075564
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18647595
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.18341797
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17990354
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16937062
95ZNF274_21170338_ChIP-Seq_K562_Hela1.15777830
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15755559
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.14404353
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13643137
99* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13640451
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.12955166
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12701144
102TP53_18474530_ChIP-ChIP_U2OS_Human1.12673362
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.12416345
104CBP_20019798_ChIP-Seq_JUKART_Human1.12317551
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12317551
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12096757
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.12071716
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11812885
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.11264115
110OCT4_18555785_Chip-Seq_ESCs_Mouse1.11152227
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10983061
112REST_21632747_ChIP-Seq_MESCs_Mouse1.10662469
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10520181
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10188838
115DCP1A_22483619_ChIP-Seq_HELA_Human1.09245894
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.08992721
117CJUN_26792858_Chip-Seq_BT549_Human1.08370476
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07811820
119FUS_26573619_Chip-Seq_HEK293_Human1.07750458
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07555714
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.06898923
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06832299
123RNF2_27304074_Chip-Seq_NSC_Mouse1.06619628
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06314579
125TCF4_23295773_ChIP-Seq_U87_Human1.06211134
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06155655
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.06078996
128STAT1_17558387_ChIP-Seq_HELA_Human1.06073672
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05949304
130ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05770052
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05527483
132P300_18555785_Chip-Seq_ESCs_Mouse1.05489751
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05258900
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05131848
135SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05074084
136AHR_22903824_ChIP-Seq_MCF-7_Human1.04986901
137BCAT_22108803_ChIP-Seq_LS180_Human1.04637872
138EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04094916
139RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04094916
140FOXO3_23340844_ChIP-Seq_DLD1_Human1.03887090
141* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03680603
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03592830
143MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03537070
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03327129
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03252550
146SOX2_18555785_Chip-Seq_ESCs_Mouse1.03245797
147EWS_26573619_Chip-Seq_HEK293_Human1.03012490
148CRX_20693478_ChIP-Seq_RETINA_Mouse1.03012153
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02917541
150DROSHA_22980978_ChIP-Seq_HELA_Human1.02650991
151CDX2_22108803_ChIP-Seq_LS180_Human1.01355570
152JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01175678
153KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00683516
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00492098
155ATF3_27146783_Chip-Seq_COLON_Human1.00413086
156* TP63_23658742_ChIP-Seq_EP156T_Human0.99616512
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99305728
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98648140
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96837885
160CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96461438
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95244168
162VDR_22108803_ChIP-Seq_LS180_Human0.95190167
163CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93458426
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92042921
165CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91787457
166CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89394961
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87853804
168NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86493828
169JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86384853
170MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79249200
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.79174105
172P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78927996
173* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78754150
174SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.78198712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous5.00423679
2MP0000372_irregular_coat_pigmentation4.87223539
3MP0003136_yellow_coat_color4.73399646
4MP0005257_abnormal_intraocular_pressure4.61889360
5MP0001986_abnormal_taste_sensitivity4.55803749
6MP0005410_abnormal_fertilization3.51656018
7MP0004019_abnormal_vitamin_homeostasis3.43929203
8MP0005171_absent_coat_pigmentation3.28026294
9MP0009697_abnormal_copulation3.14108851
10MP0005253_abnormal_eye_physiology3.04813574
11MP0005551_abnormal_eye_electrophysiolog2.92491995
12MP0001324_abnormal_eye_pigmentation2.87399572
13MP0002254_reproductive_system_inflammat2.47953233
14MP0001879_abnormal_lymphatic_vessel2.46466901
15MP0002090_abnormal_vision2.43682965
16MP0003950_abnormal_plasma_membrane2.23532324
17MP0003718_maternal_effect2.06402375
18MP0005409_darkened_coat_color2.03874210
19MP0003011_delayed_dark_adaptation14.5826877
20MP0005408_hypopigmentation1.98059309
21MP0000371_diluted_coat_color1.84394665
22MP0004185_abnormal_adipocyte_glucose1.80979033
23MP0000537_abnormal_urethra_morphology1.79370385
24MP0000569_abnormal_digit_pigmentation1.76189821
25MP0005391_vision/eye_phenotype1.75240048
26MP0002102_abnormal_ear_morphology1.71032250
27MP0000015_abnormal_ear_pigmentation1.66725408
28MP0004957_abnormal_blastocyst_morpholog1.60513852
29MP0008057_abnormal_DNA_replication1.51726167
30MP0005187_abnormal_penis_morphology1.49125455
31MP0001346_abnormal_lacrimal_gland1.43886288
32MP0003111_abnormal_nucleus_morphology1.43518297
33MP0003698_abnormal_male_reproductive1.42781606
34MP0010094_abnormal_chromosome_stability1.41542817
35MP0003693_abnormal_embryo_hatching1.39473350
36MP0006072_abnormal_retinal_apoptosis1.39292022
37MP0001929_abnormal_gametogenesis1.33433441
38MP0002092_abnormal_eye_morphology1.31444374
39MP0003077_abnormal_cell_cycle1.30662049
40MP0004381_abnormal_hair_follicle1.29795581
41MP0004885_abnormal_endolymph1.25776297
42MP0009780_abnormal_chondrocyte_physiolo1.24333832
43MP0001730_embryonic_growth_arrest1.22573587
44MP0008877_abnormal_DNA_methylation1.22154236
45MP0003878_abnormal_ear_physiology1.21492222
46MP0005377_hearing/vestibular/ear_phenot1.21492222
47MP0008961_abnormal_basal_metabolism1.20116294
48MP0000762_abnormal_tongue_morphology1.17723644
49MP0002160_abnormal_reproductive_system1.15006121
50MP0008058_abnormal_DNA_repair1.13256007
51MP0002075_abnormal_coat/hair_pigmentati1.11747271
52MP0005275_abnormal_skin_tensile1.11497628
53MP0005623_abnormal_meninges_morphology1.06636809
54MP0002234_abnormal_pharynx_morphology1.05578510
55MP0002095_abnormal_skin_pigmentation1.03056597
56MP0005197_abnormal_uvea_morphology1.02215158
57MP0001293_anophthalmia1.01731677
58MP0009053_abnormal_anal_canal1.01274832
59MP0000751_myopathy1.01166395
60MP0003221_abnormal_cardiomyocyte_apopto1.00962363
61MP0005195_abnormal_posterior_eye1.00538620
62MP0005076_abnormal_cell_differentiation1.00380085
63MP0000747_muscle_weakness0.98637543
64MP0002210_abnormal_sex_determination0.95872846
65MP0006054_spinal_hemorrhage0.93981472
66MP0000749_muscle_degeneration0.91781980
67MP0003315_abnormal_perineum_morphology0.91627015
68MP0000733_abnormal_muscle_development0.89208856
69MP0005503_abnormal_tendon_morphology0.89120561
70MP0000467_abnormal_esophagus_morphology0.88848955
71MP0003119_abnormal_digestive_system0.87079588
72MP0002269_muscular_atrophy0.86604538
73MP0002332_abnormal_exercise_endurance0.85867140
74MP0001186_pigmentation_phenotype0.81157960
75MP0006035_abnormal_mitochondrial_morpho0.80204794
76MP0008932_abnormal_embryonic_tissue0.79183210
77MP0004043_abnormal_pH_regulation0.78696549
78MP0005075_abnormal_melanosome_morpholog0.78267299
79MP0002877_abnormal_melanocyte_morpholog0.78068797
80MP0002085_abnormal_embryonic_tissue0.77989849
81MP0003252_abnormal_bile_duct0.76058566
82MP0005380_embryogenesis_phenotype0.75750757
83MP0001672_abnormal_embryogenesis/_devel0.75750757
84MP0010234_abnormal_vibrissa_follicle0.75201183
85MP0002084_abnormal_developmental_patter0.74361626
86MP0002161_abnormal_fertility/fecundity0.73986619
87MP0003935_abnormal_craniofacial_develop0.71514113
88MP0009046_muscle_twitch0.70762799
89MP0003984_embryonic_growth_retardation0.70203401
90MP0001697_abnormal_embryo_size0.70009806
91MP0005193_abnormal_anterior_eye0.69610992
92MP0000350_abnormal_cell_proliferation0.68798405
93MP0001145_abnormal_male_reproductive0.68267940
94MP0001286_abnormal_eye_development0.67742040
95MP0000653_abnormal_sex_gland0.67562985
96MP0003646_muscle_fatigue0.64477223
97MP0005174_abnormal_tail_pigmentation0.64221795
98MP0002088_abnormal_embryonic_growth/wei0.62405167
99MP0005395_other_phenotype0.62388012
100MP0009250_abnormal_appendicular_skeleto0.61656871
101MP0000579_abnormal_nail_morphology0.61225465
102MP0003890_abnormal_embryonic-extraembry0.61132403
103MP0000627_abnormal_mammary_gland0.60336465
104MP0002060_abnormal_skin_morphology0.59087023
105MP0002086_abnormal_extraembryonic_tissu0.58037390
106MP0004130_abnormal_muscle_cell0.57821949
107MP0006138_congestive_heart_failure0.57317868
108MP0004859_abnormal_synaptic_plasticity0.56912866
109MP0010678_abnormal_skin_adnexa0.56849820
110MP0008438_abnormal_cutaneous_collagen0.56833359
111MP0003690_abnormal_glial_cell0.56305776
112MP0002080_prenatal_lethality0.56017595
113MP0003786_premature_aging0.55657996
114MP0005330_cardiomyopathy0.55629239
115MP0009384_cardiac_valve_regurgitation0.55292473
116MP0001661_extended_life_span0.55248593
117MP0002928_abnormal_bile_duct0.55239754
118MP0000358_abnormal_cell_content/0.54564187
119MP0002653_abnormal_ependyma_morphology0.53610542
120MP0004270_analgesia0.51139600
121MP0002089_abnormal_postnatal_growth/wei0.51039540
122MP0002638_abnormal_pupillary_reflex0.50498885
123MP0002229_neurodegeneration0.49617382
124MP0002282_abnormal_trachea_morphology0.49180444
125MP0003938_abnormal_ear_development0.49177616
126MP0003937_abnormal_limbs/digits/tail_de0.49151610
127MP0002233_abnormal_nose_morphology0.47416835
128MP0002752_abnormal_somatic_nervous0.46552661
129MP0001485_abnormal_pinna_reflex0.44803109
130MP0000383_abnormal_hair_follicle0.43797328
131MP0005248_abnormal_Harderian_gland0.43148948
132MP0005647_abnormal_sex_gland0.42677556
133MP0003329_amyloid_beta_deposits0.41208893
134MP0002249_abnormal_larynx_morphology0.40915507
135MP0002876_abnormal_thyroid_physiology0.40355346
136MP0004233_abnormal_muscle_weight0.37867158
137MP0002796_impaired_skin_barrier0.36065138
138MP0005310_abnormal_salivary_gland0.34736204
139MP0004272_abnormal_basement_membrane0.33412584
140MP0004134_abnormal_chest_morphology0.32536647
141MP0001486_abnormal_startle_reflex0.32395890
142MP0004036_abnormal_muscle_relaxation0.32061727
143MP0004215_abnormal_myocardial_fiber0.31932495
144MP0002882_abnormal_neuron_morphology0.30487819
145MP0001348_abnormal_lacrimal_gland0.30178340
146MP0002177_abnormal_outer_ear0.30024793
147MP0008569_lethality_at_weaning0.27943711
148MP0002734_abnormal_mechanical_nocicepti0.26098189
149MP0003385_abnormal_body_wall0.23458371
150MP0000428_abnormal_craniofacial_morphol0.23086007
151MP0001501_abnormal_sleep_pattern0.22855836
152MP0002108_abnormal_muscle_morphology0.22645970
153MP0003699_abnormal_female_reproductive0.22426361
154MP0003879_abnormal_hair_cell0.22190078
155MP0002009_preneoplasia0.22029925
156MP0000427_abnormal_hair_cycle0.21716664
157MP0010030_abnormal_orbit_morphology0.21080263
158MP0003634_abnormal_glial_cell0.20729750
159MP0001963_abnormal_hearing_physiology0.20531842
160MP0003755_abnormal_palate_morphology0.19891122
161MP0000631_abnormal_neuroendocrine_gland0.18893415
162MP0010329_abnormal_lipoprotein_level0.18325327
163MP0003705_abnormal_hypodermis_morpholog0.18314877
164MP0002971_abnormal_brown_adipose0.17964754

Predicted human phenotypes

RankGene SetZ-score
1Hypopigmentation of the fundus (HP:0007894)9.84259218
2Abnormality of the fovea (HP:0000493)9.44161995
3Decreased central vision (HP:0007663)8.31624069
4Hypoplasia of the fovea (HP:0007750)6.79757795
5Aplasia/Hypoplasia of the fovea (HP:0008060)6.79757795
6Sensory axonal neuropathy (HP:0003390)6.58969094
7Progressive external ophthalmoplegia (HP:0000590)6.06721363
8Keratoconus (HP:0000563)5.97057858
9Increased corneal curvature (HP:0100692)5.97057858
10Constricted visual fields (HP:0001133)5.73382746
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.69536808
12Dynein arm defect of respiratory motile cilia (HP:0012255)5.47292595
13Absent/shortened dynein arms (HP:0200106)5.47292595
14Progressive muscle weakness (HP:0003323)5.41047713
15Aplasia/Hypoplasia of the macula (HP:0008059)5.34106542
16Choroideremia (HP:0001139)5.07366801
17Aplasia/Hypoplasia affecting the retina (HP:0008061)5.00182728
18Nonprogressive disorder (HP:0003680)4.73847800
19Progressive inability to walk (HP:0002505)4.56963450
20Fatigue (HP:0012378)4.51185054
21Blue irides (HP:0000635)4.36250050
22Clumsiness (HP:0002312)4.14559446
23Abolished electroretinogram (ERG) (HP:0000550)4.05554612
24Ragged-red muscle fibers (HP:0003200)3.94894276
25Bony spicule pigmentary retinopathy (HP:0007737)3.89769929
26Impaired proprioception (HP:0010831)3.86404579
27Central scotoma (HP:0000603)3.83280297
28Premature ovarian failure (HP:0008209)3.79942286
29Abnormal respiratory motile cilium physiology (HP:0012261)3.72780376
30Abnormal rod and cone electroretinograms (HP:0008323)3.38403618
31Ocular albinism (HP:0001107)3.26149111
32Abnormal respiratory epithelium morphology (HP:0012253)3.22978758
33Abnormal respiratory motile cilium morphology (HP:0005938)3.22978758
34Progressive hearing impairment (HP:0001730)3.12262252
35Posterior subcapsular cataract (HP:0007787)3.08065598
36Type II diabetes mellitus (HP:0005978)3.07690581
37EMG: myopathic abnormalities (HP:0003458)3.07418256
38Abnormal ciliary motility (HP:0012262)3.00006187
39Insomnia (HP:0100785)2.90272736
40Iris hypopigmentation (HP:0007730)2.86717449
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83870134
42Corneal dystrophy (HP:0001131)2.79371609
43Chronic bronchitis (HP:0004469)2.75625658
44Rhinitis (HP:0012384)2.75233214
45Scotoma (HP:0000575)2.70278479
46Dysphonia (HP:0001618)2.67719165
47Cone-rod dystrophy (HP:0000548)2.67685303
48Photophobia (HP:0000613)2.67107114
49Infertility (HP:0000789)2.63729153
50Overriding aorta (HP:0002623)2.60632492
51Poor eye contact (HP:0000817)2.58973807
52Wide intermamillary distance (HP:0006610)2.55775908
53Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.54988196
54Nasal polyposis (HP:0100582)2.52579352
55Epileptic encephalopathy (HP:0200134)2.46592552
56Hypergonadotropic hypogonadism (HP:0000815)2.45050787
57Nemaline bodies (HP:0003798)2.44624592
58Bradycardia (HP:0001662)2.43318498
59External ophthalmoplegia (HP:0000544)2.41562843
60Male infertility (HP:0003251)2.39476711
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37414347
62Increased connective tissue (HP:0009025)2.33096220
63Macular degeneration (HP:0000608)2.27121758
64Pigmentary retinal degeneration (HP:0001146)2.25823908
65Elfin facies (HP:0004428)2.24147588
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22935854
67Muscle fiber inclusion bodies (HP:0100299)2.22894301
68Spinal muscular atrophy (HP:0007269)2.19668592
69Popliteal pterygium (HP:0009756)2.12665091
70Chromsome breakage (HP:0040012)2.12145196
71Confusion (HP:0001289)2.10540816
72Aplasia involving bones of the upper limbs (HP:0009823)2.09186045
73Aplasia of the phalanges of the hand (HP:0009802)2.09186045
74Aplasia involving bones of the extremities (HP:0009825)2.09186045
75Pendular nystagmus (HP:0012043)2.02354598
76Apathy (HP:0000741)2.01074927
77Athetosis (HP:0002305)2.00336760
78Decreased electroretinogram (ERG) amplitude (HP:0000654)16.2992281
79Attenuation of retinal blood vessels (HP:0007843)10.2144812
80Abnormality of the nasal mucosa (HP:0000433)1.98553601
81Termporal pattern (HP:0011008)1.96905331
82Insidious onset (HP:0003587)1.96905331
83Renovascular hypertension (HP:0100817)1.95465596
84Trismus (HP:0000211)1.91959052
85Supernumerary spleens (HP:0009799)1.90414155
86Diaphragmatic weakness (HP:0009113)1.89006335
87Inability to walk (HP:0002540)1.87893816
88Hyperacusis (HP:0010780)1.87720624
89Median cleft lip (HP:0000161)1.85538595
90Spondylolisthesis (HP:0003302)1.85204143
91Nasal speech (HP:0001611)1.84276059
92Diminished motivation (HP:0000745)1.81406622
93Disinhibition (HP:0000734)1.80358854
94Narrow palate (HP:0000189)1.80308317
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79313190
96Upper limb muscle weakness (HP:0003484)1.76973105
97Abnormal auditory evoked potentials (HP:0006958)1.76825053
98Depression (HP:0000716)1.75488355
99Stereotypic behavior (HP:0000733)1.75008586
100Bronchiectasis (HP:0002110)1.74374895
101Freckling (HP:0001480)1.73976089
102Hypoplastic scapulae (HP:0000882)1.72174229
103Aplasia/Hypoplasia of the scapulae (HP:0006713)1.72174229
104Increased nuchal translucency (HP:0010880)1.71936500
105Abnormality of the fingertips (HP:0001211)1.71888952
106Pili torti (HP:0003777)1.71554593
107Generalized hypopigmentation of hair (HP:0011358)1.71291030
108Abnormal social behavior (HP:0012433)1.71012932
109Impaired social interactions (HP:0000735)1.71012932
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70725067
111Birth length less than 3rd percentile (HP:0003561)1.70292659
112Long toe (HP:0010511)1.69804568
113Hip contracture (HP:0003273)1.68500580
114Heterotopia (HP:0002282)1.67404618
115Hyperkalemia (HP:0002153)1.65803819
116Dysmetric saccades (HP:0000641)1.63891319
117Polar cataract (HP:0010696)1.63609609
118Bundle branch block (HP:0011710)1.61761105
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.60549342
120Abnormality of the labia minora (HP:0012880)1.59178502
121Bronchitis (HP:0012387)1.57307835
122Exercise-induced muscle cramps (HP:0003710)1.57044519
123Congenital stationary night blindness (HP:0007642)1.55123235
124Vertebral arch anomaly (HP:0008438)1.54712534
125Fibular aplasia (HP:0002990)1.54002357
126Abnormality of the phalanges of the hallux (HP:0010057)1.53768158
127Fair hair (HP:0002286)1.52116057
128Abnormal spermatogenesis (HP:0008669)1.51155881
129Nephronophthisis (HP:0000090)1.49154757
130Neurofibrillary tangles (HP:0002185)1.48176835
131Type 1 muscle fiber predominance (HP:0003803)1.45601145
132Microglossia (HP:0000171)1.45384082
133Flat cornea (HP:0007720)1.42397242
134White forelock (HP:0002211)1.41168977
135Humeroradial synostosis (HP:0003041)1.39730187
136Synostosis involving the elbow (HP:0003938)1.39730187
137Azoospermia (HP:0000027)1.37102603
138Wide nasal bridge (HP:0000431)1.36702862
139Blindness (HP:0000618)1.32201053
140Hypoplasia of the uterus (HP:0000013)1.30777363
141Abnormal finger flexion creases (HP:0006143)1.29947355
142Hyperlipoproteinemia (HP:0010980)1.29875906
143Hypoplasia of the iris (HP:0007676)1.28655283
144Hypoalphalipoproteinemia (HP:0003233)1.28292173
145Abnormality of the renal medulla (HP:0100957)1.27818894
146Hypermetropia (HP:0000540)1.25741199
147Patchy hypopigmentation of hair (HP:0011365)1.22119970
148Tubulointerstitial nephritis (HP:0001970)1.21030347
149Abnormality of vision evoked potentials (HP:0000649)1.20840358
150Medial flaring of the eyebrow (HP:0010747)1.17765636
151Recurrent sinusitis (HP:0011108)1.16608844
152Hemiparesis (HP:0001269)1.16357247
153Abnormality of macular pigmentation (HP:0008002)1.15910725
154Cerebral inclusion bodies (HP:0100314)1.14111813
155Keratoconjunctivitis (HP:0001096)1.13015041
156Abnormality of the dental pulp (HP:0006479)1.12811559
157Cardiovascular calcification (HP:0011915)1.12802235
158Tarsal synostosis (HP:0008368)1.12105576
159Ulnar deviation of finger (HP:0009465)1.11944691
160Exercise-induced myalgia (HP:0003738)1.11850024
161Overgrowth (HP:0001548)1.11462112
162Absent frontal sinuses (HP:0002688)1.10980906
163Focal motor seizures (HP:0011153)1.10354769
164Tubular atrophy (HP:0000092)1.10170403
165Subcapsular cataract (HP:0000523)1.09928817
166Retinitis pigmentosa (HP:0000510)1.09731538
167Round ear (HP:0100830)1.09558788
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.09477699
169Megalencephaly (HP:0001355)1.09027317
170Tubulointerstitial abnormality (HP:0001969)1.08288929
171Generalized hypopigmentation (HP:0007513)1.08137340
172Symphalangism affecting the phalanges of the hand (HP:0009773)1.07202247
173Recurrent otitis media (HP:0000403)1.07137884
174Aplasia/Hypoplasia of the fibula (HP:0006492)1.07071634
175Aplasia/Hypoplasia of the lens (HP:0008063)1.06590630
176Aplasia/hypoplasia of the uterus (HP:0008684)1.06056359
177Chorioretinal atrophy (HP:0000533)1.05861956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.98162760
2PDK46.33377938
3PDK36.33377938
4PDK25.23150257
5MST1R3.68129299
6EEF2K3.54455676
7PRKD33.52056863
8OBSCN3.46082184
9LATS13.02233910
10EPHA22.57515470
11TNIK2.48775127
12STK392.35019752
13CDK122.22607077
14TRIB32.13774509
15BRD41.98715640
16TTK1.96417656
17MAPKAPK31.91709943
18DDR21.74311464
19NEK11.67522253
20LMTK21.56983682
21EPHA41.56616196
22ZAK1.38028713
23TESK11.37452411
24NTRK21.35720999
25MAP3K131.34582514
26PLK11.31316340
27AKT21.30108341
28FRK1.29333069
29MAP3K31.23235448
30TSSK61.22285508
31LATS21.21735650
32LIMK11.21692629
33WNK41.18935095
34PBK1.17105790
35PDK11.16944868
36PLK41.11901962
37PTK2B1.10878825
38STK381.09004319
39CDC71.08952873
40NEK21.06540141
41MARK31.05905626
42MAP3K21.05610734
43ARAF1.04428036
44RIPK11.01698385
45ERBB41.01669341
46BUB11.00982692
47STK31.00554856
48TTN0.98893291
49PTK20.98548047
50MET0.97050571
51EIF2AK30.96431555
52FGFR20.95428525
53RPS6KB20.91885833
54RPS6KA40.91174300
55NTRK10.89265427
56ICK0.87757917
57TYRO30.84376621
58PHKG20.82943009
59PHKG10.82943009
60PRKCI0.82151030
61NEK90.81757347
62LRRK20.81434411
63CHEK10.80981299
64MAP3K40.79881279
65PKN10.79244229
66MAP3K80.78694498
67TAOK30.78236965
68TAOK10.77885166
69BRAF0.76844957
70PDPK10.76569750
71PAK60.74947811
72ABL20.74792377
73MUSK0.72127196
74MAP3K90.71669171
75PTK60.68636874
76EPHB10.68430093
77EIF2AK10.67560941
78CDK90.66607152
79PRKCH0.65537853
80RIPK40.64882862
81AURKA0.64133703
82PIK3CG0.63371374
83RET0.62862144
84MOS0.61831621
85BMX0.60502066
86AURKB0.58484550
87STK100.58457807
88MTOR0.57524805
89CAMK1G0.57007066
90FGR0.56889306
91PDGFRB0.56669544
92MARK20.56000907
93NEK60.53879344
94PRKCQ0.53781645
95ROCK20.53729518
96MAP3K120.53436440
97FER0.51982540
98PAK40.51934577
99MAPKAPK50.50857494
100SIK10.50001073
101GRK10.49885605
102CHEK20.49289138
103MAP3K60.48009777
104EPHA30.46553635
105ROCK10.46174142
106FGFR10.46132189
107MELK0.45126896
108STK160.44866447
109HIPK20.43368786
110PDGFRA0.43010157
111BMPR20.42720388
112MAP2K40.42135467
113MAPK120.42130601
114PLK30.41649786
115MAP3K140.41561096
116KSR20.41503654
117PRKG10.40549238
118PRKD20.39959349
119CSNK1D0.39857787
120CCNB10.36684893
121ATR0.36183487
122WEE10.36074218
123OXSR10.35979121
124STK38L0.35443819
125PRKAA20.34690451
126CDK70.34025342
127GSK3A0.33375656
128PAK30.33340734
129NTRK30.33184485
130PINK10.32477691
131MAP2K70.32361014
132CAMK2A0.32009120
133CDC42BPA0.31317321
134PAK20.31204110
135CDK50.31102793
136RPS6KA30.30521658
137ERBB30.30504318
138MARK10.30313505
139WNK10.30073894
140PRKACB0.29654113
141MINK10.29444415
142CAMK1D0.29302593
143PRKD10.29257020
144MAPK110.29125656
145CDK190.29060495
146DYRK30.28846005
147DYRK1B0.28494352
148PRKCE0.28368409
149SGK10.28339394
150TRPM70.28067475
151EGFR0.27469968
152RAF10.27146846
153CSK0.25996508
154JAK10.25846924
155DMPK0.25612780
156PNCK0.25560354
157MAPK140.25456509
158MAP3K70.25354149
159MAPKAPK20.25279766
160KSR10.24433838

Predicted pathways (KEGG)

RankGene SetZ-score
1Retinol metabolism_Homo sapiens_hsa008305.91565610
2Basal transcription factors_Homo sapiens_hsa030223.94443835
3Tyrosine metabolism_Homo sapiens_hsa003503.64998142
4Nitrogen metabolism_Homo sapiens_hsa009103.58293160
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49454190
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81229160
7Linoleic acid metabolism_Homo sapiens_hsa005912.58003135
8Fatty acid biosynthesis_Homo sapiens_hsa000612.56736864
9Adherens junction_Homo sapiens_hsa045202.47794682
10Vitamin digestion and absorption_Homo sapiens_hsa049772.39929242
11Phototransduction_Homo sapiens_hsa047442.30481778
12Cell cycle_Homo sapiens_hsa041102.01074171
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94678725
14Ether lipid metabolism_Homo sapiens_hsa005651.84778673
15Phenylalanine metabolism_Homo sapiens_hsa003601.75530997
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67334085
17Wnt signaling pathway_Homo sapiens_hsa043101.59462462
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58737171
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58317184
20Histidine metabolism_Homo sapiens_hsa003401.53594701
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.50519606
22mRNA surveillance pathway_Homo sapiens_hsa030151.47663900
23Melanogenesis_Homo sapiens_hsa049161.43419011
24RNA transport_Homo sapiens_hsa030131.43238801
25Bile secretion_Homo sapiens_hsa049761.40097730
26RNA degradation_Homo sapiens_hsa030181.39144007
27RNA polymerase_Homo sapiens_hsa030201.38206261
28Salivary secretion_Homo sapiens_hsa049701.35678225
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35114053
30Dorso-ventral axis formation_Homo sapiens_hsa043201.29645170
31Mismatch repair_Homo sapiens_hsa034301.28173003
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27998082
33Homologous recombination_Homo sapiens_hsa034401.25192859
34Gastric acid secretion_Homo sapiens_hsa049711.25132087
35Nucleotide excision repair_Homo sapiens_hsa034201.24482212
36Regulation of autophagy_Homo sapiens_hsa041401.23373022
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22960612
38Olfactory transduction_Homo sapiens_hsa047401.21002582
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20883123
40Chemical carcinogenesis_Homo sapiens_hsa052041.17376586
41Glucagon signaling pathway_Homo sapiens_hsa049221.17080188
42Renin secretion_Homo sapiens_hsa049241.16708579
43Non-homologous end-joining_Homo sapiens_hsa034501.16008648
44Propanoate metabolism_Homo sapiens_hsa006401.15916075
45Vitamin B6 metabolism_Homo sapiens_hsa007501.12301549
46p53 signaling pathway_Homo sapiens_hsa041151.10070200
47DNA replication_Homo sapiens_hsa030301.07381556
48ErbB signaling pathway_Homo sapiens_hsa040121.06474491
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04568041
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.04133882
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03786631
52Hedgehog signaling pathway_Homo sapiens_hsa043401.02312364
53Basal cell carcinoma_Homo sapiens_hsa052171.02154870
54One carbon pool by folate_Homo sapiens_hsa006701.01772059
55Hippo signaling pathway_Homo sapiens_hsa043901.00528549
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.95842176
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.95299294
58Long-term potentiation_Homo sapiens_hsa047200.95225250
59Thyroid cancer_Homo sapiens_hsa052160.94578274
60Amphetamine addiction_Homo sapiens_hsa050310.92858042
61Circadian entrainment_Homo sapiens_hsa047130.92637091
62TGF-beta signaling pathway_Homo sapiens_hsa043500.92483868
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91850411
64PPAR signaling pathway_Homo sapiens_hsa033200.91385614
65Pancreatic secretion_Homo sapiens_hsa049720.90647645
66Fanconi anemia pathway_Homo sapiens_hsa034600.90451587
67Arachidonic acid metabolism_Homo sapiens_hsa005900.90314395
68Fatty acid metabolism_Homo sapiens_hsa012120.90106746
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89059790
70Fatty acid degradation_Homo sapiens_hsa000710.87993071
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87107944
72Arginine and proline metabolism_Homo sapiens_hsa003300.87005927
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86442378
74ABC transporters_Homo sapiens_hsa020100.86019806
75Pyruvate metabolism_Homo sapiens_hsa006200.85210551
76Fat digestion and absorption_Homo sapiens_hsa049750.82656125
77Glutamatergic synapse_Homo sapiens_hsa047240.81757968
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81338675
79beta-Alanine metabolism_Homo sapiens_hsa004100.79549073
80Glycerolipid metabolism_Homo sapiens_hsa005610.76443092
81Calcium signaling pathway_Homo sapiens_hsa040200.72478927
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72444165
83ECM-receptor interaction_Homo sapiens_hsa045120.72066690
84cAMP signaling pathway_Homo sapiens_hsa040240.69798017
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.69377426
86Gap junction_Homo sapiens_hsa045400.68970219
87Oocyte meiosis_Homo sapiens_hsa041140.68790843
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68613721
89Proteoglycans in cancer_Homo sapiens_hsa052050.67530792
90Estrogen signaling pathway_Homo sapiens_hsa049150.67257882
91Ras signaling pathway_Homo sapiens_hsa040140.64959430
92Small cell lung cancer_Homo sapiens_hsa052220.64638593
93Pyrimidine metabolism_Homo sapiens_hsa002400.63567893
94Purine metabolism_Homo sapiens_hsa002300.60603821
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60151001
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58293803
97Dilated cardiomyopathy_Homo sapiens_hsa054140.58242371
98GABAergic synapse_Homo sapiens_hsa047270.57010367
99MicroRNAs in cancer_Homo sapiens_hsa052060.56633911
100Cocaine addiction_Homo sapiens_hsa050300.56272941
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55426810
102Epstein-Barr virus infection_Homo sapiens_hsa051690.55053263
103Long-term depression_Homo sapiens_hsa047300.54891004
104Lysine degradation_Homo sapiens_hsa003100.54159916
105Axon guidance_Homo sapiens_hsa043600.53577623
106GnRH signaling pathway_Homo sapiens_hsa049120.52771755
107Nicotine addiction_Homo sapiens_hsa050330.52262983
108Inositol phosphate metabolism_Homo sapiens_hsa005620.52254293
109Glioma_Homo sapiens_hsa052140.52057286
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51774976
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51602567
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51375921
113Oxytocin signaling pathway_Homo sapiens_hsa049210.50956134
114Selenocompound metabolism_Homo sapiens_hsa004500.50202404
115Protein digestion and absorption_Homo sapiens_hsa049740.49125716
116Glutathione metabolism_Homo sapiens_hsa004800.49071280
117Synaptic vesicle cycle_Homo sapiens_hsa047210.47589409
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47138461
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47027489
120Endocytosis_Homo sapiens_hsa041440.46330779
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46272663
122Prostate cancer_Homo sapiens_hsa052150.45620211
123Pentose phosphate pathway_Homo sapiens_hsa000300.45583987
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44728819
125Ovarian steroidogenesis_Homo sapiens_hsa049130.43898115
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43591177
127* Tight junction_Homo sapiens_hsa045300.43391747
128Dopaminergic synapse_Homo sapiens_hsa047280.42264305
129Circadian rhythm_Homo sapiens_hsa047100.40420865
130Insulin secretion_Homo sapiens_hsa049110.39511797
131Rap1 signaling pathway_Homo sapiens_hsa040150.38923259
132Arginine biosynthesis_Homo sapiens_hsa002200.38500751
133Focal adhesion_Homo sapiens_hsa045100.37638293
134Serotonergic synapse_Homo sapiens_hsa047260.37558516
135Mineral absorption_Homo sapiens_hsa049780.37181759
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37063642
137Renal cell carcinoma_Homo sapiens_hsa052110.37019783
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36099546
139FoxO signaling pathway_Homo sapiens_hsa040680.35887001
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35608314
141Pathways in cancer_Homo sapiens_hsa052000.35496151
142Malaria_Homo sapiens_hsa051440.34011243
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33487769
144Cardiac muscle contraction_Homo sapiens_hsa042600.33416868
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33121993
146Pancreatic cancer_Homo sapiens_hsa052120.32727271
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.32180173
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32122029
149Spliceosome_Homo sapiens_hsa030400.31967854
150MAPK signaling pathway_Homo sapiens_hsa040100.31795924
151Fatty acid elongation_Homo sapiens_hsa000620.30836294
152Cholinergic synapse_Homo sapiens_hsa047250.30630403
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30523036
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.30287779
155Chronic myeloid leukemia_Homo sapiens_hsa052200.30181240
156Morphine addiction_Homo sapiens_hsa050320.27597640
157Melanoma_Homo sapiens_hsa052180.27361962

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