Rank | Gene Set | Z-score |
---|---|---|
1 | sphingosine metabolic process (GO:0006670) | 9.45610945 |
2 | diol metabolic process (GO:0034311) | 8.42302076 |
3 | sphingoid metabolic process (GO:0046519) | 8.21526004 |
4 | sperm motility (GO:0030317) | 6.67494927 |
5 | fusion of sperm to egg plasma membrane (GO:0007342) | 6.55367767 |
6 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 6.42699827 |
7 | protein-chromophore linkage (GO:0018298) | 6.07593146 |
8 | acrosome reaction (GO:0007340) | 5.49116343 |
9 | DNA methylation involved in gamete generation (GO:0043046) | 5.38601608 |
10 | hemidesmosome assembly (GO:0031581) | 5.31686726 |
11 | microtubule depolymerization (GO:0007019) | 5.30895019 |
12 | lipopolysaccharide biosynthetic process (GO:0009103) | 5.30011931 |
13 | regulation of cilium movement (GO:0003352) | 5.03749608 |
14 | spermatid development (GO:0007286) | 5.01674085 |
15 | microtubule polymerization or depolymerization (GO:0031109) | 5.00176797 |
16 | notochord development (GO:0030903) | 4.92842048 |
17 | centriole replication (GO:0007099) | 4.91639301 |
18 | piRNA metabolic process (GO:0034587) | 4.82811520 |
19 | regulation of meiosis I (GO:0060631) | 4.75275230 |
20 | regulation of odontogenesis of dentin-containing tooth (GO:0042487) | 4.74412101 |
21 | chromosome condensation (GO:0030261) | 4.74382764 |
22 | plasma membrane fusion (GO:0045026) | 4.71546897 |
23 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.56579511 |
24 | L-phenylalanine metabolic process (GO:0006558) | 4.56579511 |
25 | DNA packaging (GO:0006323) | 4.53472866 |
26 | multicellular organism reproduction (GO:0032504) | 4.53005777 |
27 | ribonucleoprotein complex disassembly (GO:0032988) | 4.51327278 |
28 | positive regulation of developmental pigmentation (GO:0048087) | 4.43873130 |
29 | regulation of pigment cell differentiation (GO:0050932) | 4.27009663 |
30 | lipopolysaccharide metabolic process (GO:0008653) | 4.26703920 |
31 | organelle disassembly (GO:1903008) | 4.25486678 |
32 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.20126190 |
33 | sperm-egg recognition (GO:0035036) | 4.17037868 |
34 | axonemal dynein complex assembly (GO:0070286) | 4.14160576 |
35 | negative regulation of G2/M transition of mitotic cell cycle (GO:0010972) | 4.00860825 |
36 | centriole assembly (GO:0098534) | 3.98510584 |
37 | regulation of translational termination (GO:0006449) | 3.94593424 |
38 | musculoskeletal movement (GO:0050881) | 3.87010662 |
39 | multicellular organismal movement (GO:0050879) | 3.87010662 |
40 | microtubule severing (GO:0051013) | 3.81468527 |
41 | single strand break repair (GO:0000012) | 3.78662380 |
42 | rRNA methylation (GO:0031167) | 3.75636448 |
43 | single fertilization (GO:0007338) | 3.75254848 |
44 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.71015035 |
45 | L-phenylalanine catabolic process (GO:0006559) | 3.71015035 |
46 | reproduction (GO:0000003) | 3.69440665 |
47 | spermatogenesis (GO:0007283) | 3.67136089 |
48 | male gamete generation (GO:0048232) | 3.66043005 |
49 | sperm capacitation (GO:0048240) | 3.62162058 |
50 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 3.61766931 |
51 | establishment of protein localization to Golgi (GO:0072600) | 3.59379627 |
52 | regulation of hippo signaling (GO:0035330) | 3.59034378 |
53 | regulation of nephron tubule epithelial cell differentiation (GO:0072182) | 3.55846014 |
54 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.52360581 |
55 | paraxial mesoderm development (GO:0048339) | 3.51863329 |
56 | binding of sperm to zona pellucida (GO:0007339) | 3.51749606 |
57 | motile cilium assembly (GO:0044458) | 3.47250239 |
58 | rRNA modification (GO:0000154) | 3.47071865 |
59 | spermatid nucleus differentiation (GO:0007289) | 3.46751501 |
60 | regulation of protein glycosylation (GO:0060049) | 3.41395145 |
61 | sulfate transmembrane transport (GO:1902358) | 3.37866284 |
62 | glomerular visceral epithelial cell development (GO:0072015) | 3.37494062 |
63 | gamete generation (GO:0007276) | 3.32888193 |
64 | negative regulation of cell cycle G2/M phase transition (GO:1902750) | 3.28489540 |
65 | protein polyglutamylation (GO:0018095) | 3.27931844 |
66 | protein targeting to Golgi (GO:0000042) | 3.26706240 |
67 | regulation of gonadotropin secretion (GO:0032276) | 3.21772354 |
68 | response to pheromone (GO:0019236) | 3.19927509 |
69 | cell-cell recognition (GO:0009988) | 3.18812970 |
70 | fertilization (GO:0009566) | 3.14012026 |
71 | iron coordination entity transport (GO:1901678) | 3.12647574 |
72 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.12499988 |
73 | regulation of transforming growth factor beta2 production (GO:0032909) | 3.09692484 |
74 | regulation of microtubule-based movement (GO:0060632) | 3.08154008 |
75 | SMAD protein complex assembly (GO:0007183) | 3.01967937 |
76 | glomerular epithelial cell development (GO:0072310) | 2.98994752 |
77 | protein localization to Golgi apparatus (GO:0034067) | 2.98924923 |
78 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.97945818 |
79 | phosphatidylethanolamine metabolic process (GO:0046337) | 2.95095363 |
80 | regulation of epithelial cell differentiation involved in kidney development (GO:2000696) | 2.94973120 |
81 | opioid receptor signaling pathway (GO:0038003) | 2.91117612 |
82 | germ cell development (GO:0007281) | 2.90744227 |
83 | regulation of Rab GTPase activity (GO:0032313) | 2.89927283 |
84 | positive regulation of Rab GTPase activity (GO:0032851) | 2.89927283 |
85 | protein retention in ER lumen (GO:0006621) | 2.87831435 |
86 | mitochondrial fission (GO:0000266) | 2.87782823 |
87 | cell-cell junction maintenance (GO:0045217) | 2.86239440 |
88 | cellular ketone body metabolic process (GO:0046950) | 2.85466806 |
89 | sulfate transport (GO:0008272) | 2.85462443 |
90 | detection of light stimulus involved in visual perception (GO:0050908) | 2.84728964 |
91 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.84728964 |
92 | calcium ion-dependent exocytosis (GO:0017156) | 2.83528200 |
93 | cellular response to gamma radiation (GO:0071480) | 2.82962908 |
94 | epithelial cilium movement (GO:0003351) | 2.81923751 |
95 | nodal signaling pathway (GO:0038092) | 2.79665405 |
96 | protein K48-linked deubiquitination (GO:0071108) | 2.79422823 |
97 | regulation of keratinocyte proliferation (GO:0010837) | 2.78122110 |
98 | primary amino compound metabolic process (GO:1901160) | 2.78117011 |
99 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 2.77644669 |
100 | membrane raft organization (GO:0031579) | 2.74043811 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.43460955 |
2 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.67475162 |
3 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.46122864 |
4 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.41198247 |
5 | CJUN_26792858_Chip-Seq_BT549_Human | 2.35307679 |
6 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.32592019 |
7 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.21130122 |
8 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.17249477 |
9 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 2.12547458 |
10 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 2.09953350 |
11 | TP53_18474530_ChIP-ChIP_U2OS_Human | 2.08101876 |
12 | VDR_22108803_ChIP-Seq_LS180_Human | 2.04579495 |
13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.02068043 |
14 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 2.01742170 |
15 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.90945695 |
16 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.90945695 |
17 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.88641566 |
18 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.80018374 |
19 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.77870032 |
20 | P300_19829295_ChIP-Seq_ESCs_Human | 1.77287315 |
21 | TP53_16413492_ChIP-PET_HCT116_Human | 1.75162612 |
22 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.74724243 |
23 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.74724243 |
24 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.74434502 |
25 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.74434502 |
26 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.72122029 |
27 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.71276864 |
28 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.69422501 |
29 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.67231557 |
30 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.64326068 |
31 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.62851649 |
32 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.60943491 |
33 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.60276134 |
34 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.58428772 |
35 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.58227130 |
36 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.56347393 |
37 | * TP63_23658742_ChIP-Seq_EP156T_Human | 1.55118445 |
38 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.53791949 |
39 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.51387747 |
40 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.50058932 |
41 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.48001095 |
42 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.47897354 |
43 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.47688082 |
44 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.47587845 |
45 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.46592164 |
46 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.45642974 |
47 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.45362374 |
48 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.44476797 |
49 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.44266750 |
50 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.43752921 |
51 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.40668923 |
52 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.40656734 |
53 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.40104217 |
54 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.39957122 |
55 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.39957122 |
56 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.38904719 |
57 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.38082530 |
58 | AR_25329375_ChIP-Seq_VCAP_Human | 1.37278911 |
59 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 1.37190365 |
60 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.37011740 |
61 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.33781203 |
62 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.33051104 |
63 | CBP_21632823_ChIP-Seq_H3396_Human | 1.33036908 |
64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.32251447 |
65 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.31935683 |
66 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.29108816 |
67 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.28637502 |
68 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.27503513 |
69 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.27370289 |
70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.27075421 |
71 | TCF4_23295773_ChIP-Seq_U87_Human | 1.25878554 |
72 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.24781579 |
73 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23819180 |
74 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.23043640 |
75 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.21549705 |
76 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.21050402 |
77 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.20588211 |
78 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.18419426 |
79 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.17354443 |
80 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.17354443 |
81 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.15023050 |
82 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.14813474 |
83 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.14693603 |
84 | * ERA_21632823_ChIP-Seq_H3396_Human | 1.13651015 |
85 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.13206201 |
86 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.09628665 |
87 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.08304892 |
88 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.07931208 |
89 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.06478128 |
90 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.05399910 |
91 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.02830067 |
92 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.02328396 |
93 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.01109238 |
94 | FUS_26573619_Chip-Seq_HEK293_Human | 0.99275873 |
95 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.98542265 |
96 | RXR_22108803_ChIP-Seq_LS180_Human | 0.96920224 |
97 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96579564 |
98 | PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human | 0.94496859 |
99 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.93883029 |
100 | * E2F1_20622854_ChIP-Seq_HELA_Human | 0.92831363 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005410_abnormal_fertilization | 5.65709743 |
2 | MP0002837_dystrophic_cardiac_calcinosis | 5.65506954 |
3 | MP0003136_yellow_coat_color | 5.03907027 |
4 | MP0002653_abnormal_ependyma_morphology | 4.55217971 |
5 | MP0005171_absent_coat_pigmentation | 3.95587820 |
6 | MP0003879_abnormal_hair_cell | 3.86044180 |
7 | MP0005670_abnormal_white_adipose | 3.83392587 |
8 | MP0003045_fibrosis | 3.83177138 |
9 | MP0003950_abnormal_plasma_membrane | 3.78071337 |
10 | MP0003646_muscle_fatigue | 3.53509199 |
11 | MP0003890_abnormal_embryonic-extraembry | 2.51480105 |
12 | MP0000749_muscle_degeneration | 2.46821769 |
13 | MP0003878_abnormal_ear_physiology | 2.37234885 |
14 | MP0005377_hearing/vestibular/ear_phenot | 2.37234885 |
15 | MP0002138_abnormal_hepatobiliary_system | 2.05810175 |
16 | MP0003698_abnormal_male_reproductive | 1.95351962 |
17 | MP0002269_muscular_atrophy | 1.88906063 |
18 | MP0004233_abnormal_muscle_weight | 1.84967905 |
19 | MP0002168_other_aberrant_phenotype | 1.84826415 |
20 | MP0001501_abnormal_sleep_pattern | 1.84363122 |
21 | MP0000678_abnormal_parathyroid_gland | 1.76171886 |
22 | MP0005451_abnormal_body_composition | 1.70174828 |
23 | MP0001929_abnormal_gametogenesis | 1.68525110 |
24 | MP0000751_myopathy | 1.68061886 |
25 | MP0005395_other_phenotype | 1.55126221 |
26 | MP0005085_abnormal_gallbladder_physiolo | 1.50623315 |
27 | MP0001348_abnormal_lacrimal_gland | 1.49717231 |
28 | MP0009053_abnormal_anal_canal | 1.43427177 |
29 | MP0003718_maternal_effect | 1.42435075 |
30 | MP0002332_abnormal_exercise_endurance | 1.42371927 |
31 | MP0000762_abnormal_tongue_morphology | 1.34326294 |
32 | MP0004381_abnormal_hair_follicle | 1.32667473 |
33 | MP0000579_abnormal_nail_morphology | 1.30440966 |
34 | MP0000534_abnormal_ureter_morphology | 1.24497916 |
35 | MP0005083_abnormal_biliary_tract | 1.23934309 |
36 | MP0009764_decreased_sensitivity_to | 1.14472601 |
37 | MP0002234_abnormal_pharynx_morphology | 1.13042653 |
38 | MP0004272_abnormal_basement_membrane | 1.11805397 |
39 | MP0005423_abnormal_somatic_nervous | 1.10089156 |
40 | MP0002161_abnormal_fertility/fecundity | 1.07380075 |
41 | MP0002160_abnormal_reproductive_system | 1.06811742 |
42 | MP0002796_impaired_skin_barrier | 0.98579162 |
43 | MP0000569_abnormal_digit_pigmentation | 0.97999759 |
44 | MP0003195_calcinosis | 0.97515962 |
45 | MP0002060_abnormal_skin_morphology | 0.96750827 |
46 | MP0000750_abnormal_muscle_regeneration | 0.96729419 |
47 | MP0002210_abnormal_sex_determination | 0.96726945 |
48 | MP0009780_abnormal_chondrocyte_physiolo | 0.95478269 |
49 | MP0000427_abnormal_hair_cycle | 0.94943038 |
50 | MP0002938_white_spotting | 0.91126143 |
51 | MP0000467_abnormal_esophagus_morphology | 0.86217789 |
52 | MP0010352_gastrointestinal_tract_polyps | 0.84681141 |
53 | MP0001873_stomach_inflammation | 0.83440140 |
54 | MP0003137_abnormal_impulse_conducting | 0.83337800 |
55 | MP0003705_abnormal_hypodermis_morpholog | 0.80631177 |
56 | MP0010771_integument_phenotype | 0.79268953 |
57 | MP0001968_abnormal_touch/_nociception | 0.77831481 |
58 | MP0004957_abnormal_blastocyst_morpholog | 0.73348541 |
59 | MP0001984_abnormal_olfaction | 0.72722603 |
60 | MP0005551_abnormal_eye_electrophysiolog | 0.71955396 |
61 | MP0003806_abnormal_nucleotide_metabolis | 0.71222879 |
62 | MP0001216_abnormal_epidermal_layer | 0.70716144 |
63 | MP0010234_abnormal_vibrissa_follicle | 0.68675140 |
64 | MP0002876_abnormal_thyroid_physiology | 0.66840573 |
65 | MP0003943_abnormal_hepatobiliary_system | 0.65866264 |
66 | MP0002282_abnormal_trachea_morphology | 0.65501516 |
67 | MP0003300_gastrointestinal_ulcer | 0.64143843 |
68 | MP0002095_abnormal_skin_pigmentation | 0.62943460 |
69 | MP0000358_abnormal_cell_content/ | 0.61915316 |
70 | MP0005266_abnormal_metabolism | 0.61521451 |
71 | MP0003453_abnormal_keratinocyte_physiol | 0.61495429 |
72 | MP0005360_urolithiasis | 0.61455524 |
73 | MP0002132_abnormal_respiratory_system | 0.61107985 |
74 | MP0005501_abnormal_skin_physiology | 0.60748870 |
75 | MP0002254_reproductive_system_inflammat | 0.60541583 |
76 | MP0000681_abnormal_thyroid_gland | 0.60115926 |
77 | MP0008770_decreased_survivor_rate | 0.58526593 |
78 | MP0002272_abnormal_nervous_system | 0.58423865 |
79 | MP0001145_abnormal_male_reproductive | 0.58308667 |
80 | MP0009115_abnormal_fat_cell | 0.57808483 |
81 | MP0003638_abnormal_response/metabolism_ | 0.57250205 |
82 | MP0000653_abnormal_sex_gland | 0.54856923 |
83 | MP0001765_abnormal_ion_homeostasis | 0.54119970 |
84 | MP0005408_hypopigmentation | 0.53349934 |
85 | MP0000613_abnormal_salivary_gland | 0.50199380 |
86 | MP0005365_abnormal_bile_salt | 0.50024099 |
87 | MP0005023_abnormal_wound_healing | 0.49526716 |
88 | MP0005319_abnormal_enzyme/_coenzyme | 0.49162754 |
89 | MP0002928_abnormal_bile_duct | 0.48963913 |
90 | MP0003315_abnormal_perineum_morphology | 0.48706235 |
91 | MP0005389_reproductive_system_phenotype | 0.48217318 |
92 | MP0000470_abnormal_stomach_morphology | 0.47523767 |
93 | MP0008789_abnormal_olfactory_epithelium | 0.47505306 |
94 | MP0004510_myositis | 0.47494836 |
95 | MP0010678_abnormal_skin_adnexa | 0.47382058 |
96 | MP0009046_muscle_twitch | 0.47055537 |
97 | MP0003936_abnormal_reproductive_system | 0.47033986 |
98 | MP0002971_abnormal_brown_adipose | 0.46498786 |
99 | MP0002733_abnormal_thermal_nociception | 0.46399884 |
100 | MP0005666_abnormal_adipose_tissue | 0.46387492 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Amelogenesis imperfecta (HP:0000705) | 6.89003268 |
2 | Focal motor seizures (HP:0011153) | 4.86889597 |
3 | Neonatal respiratory distress (HP:0002643) | 4.77617091 |
4 | Severe visual impairment (HP:0001141) | 4.76629384 |
5 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 4.34782939 |
6 | Milia (HP:0001056) | 3.96471250 |
7 | Bilateral sensorineural hearing impairment (HP:0008619) | 3.81074194 |
8 | Congenital ichthyosiform erythroderma (HP:0007431) | 3.70848118 |
9 | Parakeratosis (HP:0001036) | 3.41434035 |
10 | Attenuation of retinal blood vessels (HP:0007843) | 3.40681835 |
11 | Absent/shortened dynein arms (HP:0200106) | 3.39463825 |
12 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.39463825 |
13 | Thick nail (HP:0001805) | 3.27049405 |
14 | Pancreatic cysts (HP:0001737) | 3.26047461 |
15 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.26016636 |
16 | Bony spicule pigmentary retinopathy (HP:0007737) | 3.24109317 |
17 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.23524271 |
18 | Abnormal drinking behavior (HP:0030082) | 3.20829831 |
19 | Polydipsia (HP:0001959) | 3.20829831 |
20 | Conjugated hyperbilirubinemia (HP:0002908) | 3.13049293 |
21 | Abnormality of macular pigmentation (HP:0008002) | 3.07438054 |
22 | Difficulty walking (HP:0002355) | 3.00748550 |
23 | Chronic hepatic failure (HP:0100626) | 2.96863085 |
24 | Urethral obstruction (HP:0000796) | 2.91518198 |
25 | Acanthocytosis (HP:0001927) | 2.87858977 |
26 | Facial shape deformation (HP:0011334) | 2.85905029 |
27 | Potter facies (HP:0002009) | 2.85905029 |
28 | Tubular atrophy (HP:0000092) | 2.78762313 |
29 | Thyroid-stimulating hormone excess (HP:0002925) | 2.78462405 |
30 | Focal segmental glomerulosclerosis (HP:0000097) | 2.77971136 |
31 | Right ventricular cardiomyopathy (HP:0011663) | 2.76002343 |
32 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.74841865 |
33 | Atrophic scars (HP:0001075) | 2.71399019 |
34 | Renal tubular acidosis (HP:0001947) | 2.65240313 |
35 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.63688561 |
36 | Plantar hyperkeratosis (HP:0007556) | 2.62165916 |
37 | Tetany (HP:0001281) | 2.60706646 |
38 | Abnormal ciliary motility (HP:0012262) | 2.57076414 |
39 | Abnormality of the renal medulla (HP:0100957) | 2.49833862 |
40 | Alopecia of scalp (HP:0002293) | 2.49516873 |
41 | Male infertility (HP:0003251) | 2.48892776 |
42 | Dialeptic seizures (HP:0011146) | 2.48727705 |
43 | Febrile seizures (HP:0002373) | 2.47773529 |
44 | Horizontal nystagmus (HP:0000666) | 2.45754750 |
45 | Onycholysis (HP:0001806) | 2.43471911 |
46 | Severe muscular hypotonia (HP:0006829) | 2.41832537 |
47 | Hypokinesia (HP:0002375) | 2.37528853 |
48 | Polyuria (HP:0000103) | 2.33515118 |
49 | Nephronophthisis (HP:0000090) | 2.33382289 |
50 | Flattened epiphyses (HP:0003071) | 2.33044528 |
51 | Stage 5 chronic kidney disease (HP:0003774) | 2.29012935 |
52 | Abnormal albumin level (HP:0012116) | 2.28901187 |
53 | Hypoalbuminemia (HP:0003073) | 2.28901187 |
54 | Cerebellar dysplasia (HP:0007033) | 2.28695771 |
55 | Ulnar bowing (HP:0003031) | 2.24217987 |
56 | Glomerulosclerosis (HP:0000096) | 2.24052697 |
57 | Portal hypertension (HP:0001409) | 2.22276592 |
58 | Abnormality of the renal cortex (HP:0011035) | 2.22200977 |
59 | Tubulointerstitial fibrosis (HP:0005576) | 2.21168468 |
60 | Enlarged epiphyses (HP:0010580) | 2.16944804 |
61 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.15671485 |
62 | Pendular nystagmus (HP:0012043) | 2.14924814 |
63 | Upper limb muscle weakness (HP:0003484) | 2.14900709 |
64 | Hyperkalemia (HP:0002153) | 2.14034156 |
65 | Ileus (HP:0002595) | 2.11709902 |
66 | Poikiloderma (HP:0001029) | 2.10239839 |
67 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.08667721 |
68 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.08667721 |
69 | Abnormal urine output (HP:0012590) | 2.07653646 |
70 | Tubulointerstitial abnormality (HP:0001969) | 2.06645647 |
71 | Palmoplantar hyperkeratosis (HP:0000972) | 2.05224853 |
72 | Abnormality of the hepatic vasculature (HP:0006707) | 2.03167415 |
73 | Nephrocalcinosis (HP:0000121) | 2.02274916 |
74 | Fragile nails (HP:0001808) | 2.01254263 |
75 | Abnormality of the neuromuscular junction (HP:0003398) | 2.01152257 |
76 | Fatigable weakness (HP:0003473) | 2.01152257 |
77 | Dehydration (HP:0001944) | 2.00553149 |
78 | Focal seizures (HP:0007359) | 1.98652466 |
79 | Aplastic anemia (HP:0001915) | 1.97896046 |
80 | Volvulus (HP:0002580) | 1.96278793 |
81 | Nasal polyposis (HP:0100582) | 1.94340956 |
82 | Inability to walk (HP:0002540) | 1.93035702 |
83 | Vertebral arch anomaly (HP:0008438) | 1.92449926 |
84 | Chronic bronchitis (HP:0004469) | 1.90092699 |
85 | Palmar hyperkeratosis (HP:0010765) | 1.88716955 |
86 | Bell-shaped thorax (HP:0001591) | 1.87843855 |
87 | Gaze-evoked nystagmus (HP:0000640) | 1.87605120 |
88 | Asymmetric septal hypertrophy (HP:0001670) | 1.86691469 |
89 | Type II lissencephaly (HP:0007260) | 1.86071376 |
90 | Infertility (HP:0000789) | 1.80504635 |
91 | Abnormality of renal excretion (HP:0011036) | 1.79462387 |
92 | Renovascular hypertension (HP:0100817) | 1.78302109 |
93 | Subcapsular cataract (HP:0000523) | 1.77687962 |
94 | Radial bowing (HP:0002986) | 1.77663256 |
95 | Cystic liver disease (HP:0006706) | 1.77140636 |
96 | Enlarged kidneys (HP:0000105) | 1.76814499 |
97 | Polar cataract (HP:0010696) | 1.76434757 |
98 | Fibular aplasia (HP:0002990) | 1.72648222 |
99 | Absent epiphyses (HP:0010577) | 1.72445220 |
100 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.72445220 |
Rank | Gene Set | Z-score |
---|---|---|
1 | LATS1 | 8.54737966 |
2 | STK38L | 5.78646180 |
3 | LATS2 | 5.22142562 |
4 | EPHA2 | 4.18964515 |
5 | NEK1 | 3.38238723 |
6 | STK38 | 3.37021252 |
7 | MST1R | 2.82692446 |
8 | FRK | 2.73639371 |
9 | PLK4 | 2.61493199 |
10 | PRKD3 | 2.52284385 |
11 | IRAK3 | 2.51294731 |
12 | NEK2 | 2.44697681 |
13 | TESK1 | 1.88410570 |
14 | INSRR | 1.82629714 |
15 | STK3 | 1.75911374 |
16 | ZAK | 1.61242819 |
17 | MET | 1.51664757 |
18 | MAP3K9 | 1.34874374 |
19 | ADRBK2 | 1.30545362 |
20 | PTK2B | 1.13891691 |
21 | BMPR1B | 1.06844344 |
22 | MAP2K2 | 1.06710093 |
23 | NME2 | 1.03729199 |
24 | LMTK2 | 1.03167080 |
25 | MELK | 1.01036383 |
26 | MOS | 0.96711876 |
27 | KSR2 | 0.94559603 |
28 | PIK3CG | 0.94359801 |
29 | MAP4K2 | 0.88565352 |
30 | PDPK1 | 0.85244889 |
31 | PLK2 | 0.77920869 |
32 | DDR2 | 0.77681926 |
33 | ADRBK1 | 0.75748465 |
34 | ACVR1B | 0.73870298 |
35 | ARAF | 0.70934362 |
36 | PTK2 | 0.68371035 |
37 | MST4 | 0.67800031 |
38 | MAP3K2 | 0.66984110 |
39 | LIMK1 | 0.64041353 |
40 | NEK6 | 0.63599483 |
41 | STK10 | 0.63422157 |
42 | PAK4 | 0.58605894 |
43 | PRKCI | 0.57203680 |
44 | PRKAA2 | 0.57134421 |
45 | ERBB4 | 0.56242141 |
46 | TGFBR2 | 0.48058553 |
47 | MAP2K1 | 0.47993927 |
48 | STK39 | 0.45102506 |
49 | TGFBR1 | 0.43828187 |
50 | MAPK15 | 0.42543560 |
51 | NME1 | 0.41655971 |
52 | CSNK1A1L | 0.41003353 |
53 | CDK8 | 0.40375229 |
54 | TAF1 | 0.39419480 |
55 | EIF2AK3 | 0.38847665 |
56 | PIM2 | 0.37514457 |
57 | CDK7 | 0.36705021 |
58 | EPHB2 | 0.34701990 |
59 | MAP3K8 | 0.33741284 |
60 | AKT3 | 0.33049103 |
61 | CDK12 | 0.32920695 |
62 | MAP3K12 | 0.32450103 |
63 | SIK2 | 0.31406692 |
64 | PBK | 0.30865152 |
65 | MAP3K3 | 0.30474259 |
66 | BCR | 0.29988573 |
67 | MKNK2 | 0.27881787 |
68 | BRAF | 0.27195809 |
69 | FLT3 | 0.26975228 |
70 | PRKG2 | 0.26655234 |
71 | GRK7 | 0.24087694 |
72 | BUB1 | 0.23858331 |
73 | TRIM28 | 0.23456206 |
74 | AKT2 | 0.23439971 |
75 | ERN1 | 0.22904214 |
76 | CAMK2A | 0.22805563 |
77 | PLK1 | 0.22757138 |
78 | NLK | 0.22451061 |
79 | DAPK1 | 0.22414449 |
80 | FER | 0.20898800 |
81 | PRKCE | 0.20608268 |
82 | WNK4 | 0.19470367 |
83 | MAP2K7 | 0.17410190 |
84 | PAK1 | 0.16286645 |
85 | NTRK1 | 0.15859740 |
86 | PNCK | 0.15211828 |
87 | PDK1 | 0.14552490 |
88 | ABL2 | 0.12650228 |
89 | VRK2 | 0.12434744 |
90 | CSNK1A1 | 0.11537322 |
91 | CHEK2 | 0.11493481 |
92 | AURKA | 0.10609072 |
93 | BMX | 0.10202209 |
94 | PDK2 | 0.09740826 |
95 | STK24 | 0.09717801 |
96 | CAMK2G | 0.09470250 |
97 | PRKD1 | 0.09294952 |
98 | OXSR1 | 0.08501056 |
99 | NEK9 | 0.08440915 |
100 | CHUK | 0.08289273 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 5.55885892 |
2 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 3.55963309 |
3 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.37190904 |
4 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 3.33307004 |
5 | Phototransduction_Homo sapiens_hsa04744 | 3.28754135 |
6 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 3.05287305 |
7 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.86533110 |
8 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 2.10731251 |
9 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.02949739 |
10 | Taste transduction_Homo sapiens_hsa04742 | 2.00618571 |
11 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.98628054 |
12 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.98603722 |
13 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.95455244 |
14 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.94675296 |
15 | Olfactory transduction_Homo sapiens_hsa04740 | 1.84399100 |
16 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.79089041 |
17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.73062998 |
18 | Salivary secretion_Homo sapiens_hsa04970 | 1.72731525 |
19 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.70968437 |
20 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.67394781 |
21 | Sulfur relay system_Homo sapiens_hsa04122 | 1.61790557 |
22 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.61477935 |
23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.50856926 |
24 | Nicotine addiction_Homo sapiens_hsa05033 | 1.43885911 |
25 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.35516724 |
26 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.24848281 |
27 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.20160871 |
28 | ABC transporters_Homo sapiens_hsa02010 | 1.14634300 |
29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.14035808 |
30 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.11269749 |
31 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.02871341 |
32 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.01472360 |
33 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.00984043 |
34 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.00949625 |
35 | Adherens junction_Homo sapiens_hsa04520 | 0.99796233 |
36 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.98853844 |
37 | Morphine addiction_Homo sapiens_hsa05032 | 0.90229085 |
38 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.89043950 |
39 | Purine metabolism_Homo sapiens_hsa00230 | 0.88764354 |
40 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.88332509 |
41 | Thyroid cancer_Homo sapiens_hsa05216 | 0.87014826 |
42 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.85472880 |
43 | Tight junction_Homo sapiens_hsa04530 | 0.84597518 |
44 | Histidine metabolism_Homo sapiens_hsa00340 | 0.83430868 |
45 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.82072204 |
46 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.81561437 |
47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.80673005 |
48 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.79551697 |
49 | Focal adhesion_Homo sapiens_hsa04510 | 0.79177149 |
50 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.76790672 |
51 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.75857974 |
52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.71220929 |
53 | Homologous recombination_Homo sapiens_hsa03440 | 0.70530078 |
54 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.69688622 |
55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.69660183 |
56 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.69611484 |
57 | RNA transport_Homo sapiens_hsa03013 | 0.66851179 |
58 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.64758136 |
59 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.64657457 |
60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.58956241 |
61 | RNA polymerase_Homo sapiens_hsa03020 | 0.58640163 |
62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.58009262 |
63 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.56492389 |
64 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.56446085 |
65 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.56243836 |
66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55155491 |
67 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.50287220 |
68 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.49687619 |
69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.49144278 |
70 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.48320540 |
71 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.47153067 |
72 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.47091654 |
73 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.45887428 |
74 | Bile secretion_Homo sapiens_hsa04976 | 0.45859520 |
75 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.42931618 |
76 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.42743945 |
77 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.40112201 |
78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39497279 |
79 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38951767 |
80 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.36067251 |
81 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.35596854 |
82 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35402701 |
83 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.35239721 |
84 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.34458106 |
85 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.33718193 |
86 | Retinol metabolism_Homo sapiens_hsa00830 | 0.28212072 |
87 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.24760512 |
88 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.24612222 |
89 | Cell cycle_Homo sapiens_hsa04110 | 0.24534658 |
90 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.24140393 |
91 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.22603349 |
92 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.20407300 |
93 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.19649176 |
94 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.19590650 |
95 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.19193070 |
96 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.18030067 |
97 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.17406877 |
98 | Mineral absorption_Homo sapiens_hsa04978 | 0.16809642 |
99 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.15273751 |
100 | Galactose metabolism_Homo sapiens_hsa00052 | 0.15267733 |