MYH16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)9.45610945
2diol metabolic process (GO:0034311)8.42302076
3sphingoid metabolic process (GO:0046519)8.21526004
4sperm motility (GO:0030317)6.67494927
5fusion of sperm to egg plasma membrane (GO:0007342)6.55367767
6regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.42699827
7protein-chromophore linkage (GO:0018298)6.07593146
8acrosome reaction (GO:0007340)5.49116343
9DNA methylation involved in gamete generation (GO:0043046)5.38601608
10hemidesmosome assembly (GO:0031581)5.31686726
11microtubule depolymerization (GO:0007019)5.30895019
12lipopolysaccharide biosynthetic process (GO:0009103)5.30011931
13regulation of cilium movement (GO:0003352)5.03749608
14spermatid development (GO:0007286)5.01674085
15microtubule polymerization or depolymerization (GO:0031109)5.00176797
16notochord development (GO:0030903)4.92842048
17centriole replication (GO:0007099)4.91639301
18piRNA metabolic process (GO:0034587)4.82811520
19regulation of meiosis I (GO:0060631)4.75275230
20regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.74412101
21chromosome condensation (GO:0030261)4.74382764
22plasma membrane fusion (GO:0045026)4.71546897
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.56579511
24L-phenylalanine metabolic process (GO:0006558)4.56579511
25DNA packaging (GO:0006323)4.53472866
26multicellular organism reproduction (GO:0032504)4.53005777
27ribonucleoprotein complex disassembly (GO:0032988)4.51327278
28positive regulation of developmental pigmentation (GO:0048087)4.43873130
29regulation of pigment cell differentiation (GO:0050932)4.27009663
30lipopolysaccharide metabolic process (GO:0008653)4.26703920
31organelle disassembly (GO:1903008)4.25486678
32bundle of His cell to Purkinje myocyte communication (GO:0086069)4.20126190
33sperm-egg recognition (GO:0035036)4.17037868
34axonemal dynein complex assembly (GO:0070286)4.14160576
35negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.00860825
36centriole assembly (GO:0098534)3.98510584
37regulation of translational termination (GO:0006449)3.94593424
38musculoskeletal movement (GO:0050881)3.87010662
39multicellular organismal movement (GO:0050879)3.87010662
40microtubule severing (GO:0051013)3.81468527
41single strand break repair (GO:0000012)3.78662380
42rRNA methylation (GO:0031167)3.75636448
43single fertilization (GO:0007338)3.75254848
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71015035
45L-phenylalanine catabolic process (GO:0006559)3.71015035
46reproduction (GO:0000003)3.69440665
47spermatogenesis (GO:0007283)3.67136089
48male gamete generation (GO:0048232)3.66043005
49sperm capacitation (GO:0048240)3.62162058
50negative regulation of glycoprotein biosynthetic process (GO:0010561)3.61766931
51establishment of protein localization to Golgi (GO:0072600)3.59379627
52regulation of hippo signaling (GO:0035330)3.59034378
53regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.55846014
54cilium or flagellum-dependent cell motility (GO:0001539)3.52360581
55paraxial mesoderm development (GO:0048339)3.51863329
56binding of sperm to zona pellucida (GO:0007339)3.51749606
57motile cilium assembly (GO:0044458)3.47250239
58rRNA modification (GO:0000154)3.47071865
59spermatid nucleus differentiation (GO:0007289)3.46751501
60regulation of protein glycosylation (GO:0060049)3.41395145
61sulfate transmembrane transport (GO:1902358)3.37866284
62glomerular visceral epithelial cell development (GO:0072015)3.37494062
63gamete generation (GO:0007276)3.32888193
64negative regulation of cell cycle G2/M phase transition (GO:1902750)3.28489540
65protein polyglutamylation (GO:0018095)3.27931844
66protein targeting to Golgi (GO:0000042)3.26706240
67regulation of gonadotropin secretion (GO:0032276)3.21772354
68response to pheromone (GO:0019236)3.19927509
69cell-cell recognition (GO:0009988)3.18812970
70fertilization (GO:0009566)3.14012026
71iron coordination entity transport (GO:1901678)3.12647574
72regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.12499988
73regulation of transforming growth factor beta2 production (GO:0032909)3.09692484
74regulation of microtubule-based movement (GO:0060632)3.08154008
75SMAD protein complex assembly (GO:0007183)3.01967937
76glomerular epithelial cell development (GO:0072310)2.98994752
77protein localization to Golgi apparatus (GO:0034067)2.98924923
78retrograde transport, vesicle recycling within Golgi (GO:0000301)2.97945818
79phosphatidylethanolamine metabolic process (GO:0046337)2.95095363
80regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.94973120
81opioid receptor signaling pathway (GO:0038003)2.91117612
82germ cell development (GO:0007281)2.90744227
83regulation of Rab GTPase activity (GO:0032313)2.89927283
84positive regulation of Rab GTPase activity (GO:0032851)2.89927283
85protein retention in ER lumen (GO:0006621)2.87831435
86mitochondrial fission (GO:0000266)2.87782823
87cell-cell junction maintenance (GO:0045217)2.86239440
88cellular ketone body metabolic process (GO:0046950)2.85466806
89sulfate transport (GO:0008272)2.85462443
90detection of light stimulus involved in visual perception (GO:0050908)2.84728964
91detection of light stimulus involved in sensory perception (GO:0050962)2.84728964
92calcium ion-dependent exocytosis (GO:0017156)2.83528200
93cellular response to gamma radiation (GO:0071480)2.82962908
94epithelial cilium movement (GO:0003351)2.81923751
95nodal signaling pathway (GO:0038092)2.79665405
96protein K48-linked deubiquitination (GO:0071108)2.79422823
97regulation of keratinocyte proliferation (GO:0010837)2.78122110
98primary amino compound metabolic process (GO:1901160)2.78117011
99phosphatidylethanolamine biosynthetic process (GO:0006646)2.77644669
100membrane raft organization (GO:0031579)2.74043811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.43460955
2JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.67475162
3CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46122864
4JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.41198247
5CJUN_26792858_Chip-Seq_BT549_Human2.35307679
6AR_21572438_ChIP-Seq_LNCaP_Human2.32592019
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21130122
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.17249477
9PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12547458
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09953350
11TP53_18474530_ChIP-ChIP_U2OS_Human2.08101876
12VDR_22108803_ChIP-Seq_LS180_Human2.04579495
13ZNF274_21170338_ChIP-Seq_K562_Hela2.02068043
14PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.01742170
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90945695
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90945695
17NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.88641566
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80018374
19P63_26484246_Chip-Seq_KERATINOCYTES_Human1.77870032
20P300_19829295_ChIP-Seq_ESCs_Human1.77287315
21TP53_16413492_ChIP-PET_HCT116_Human1.75162612
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74724243
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74724243
24CBP_20019798_ChIP-Seq_JUKART_Human1.74434502
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74434502
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72122029
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.71276864
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69422501
29* ER_23166858_ChIP-Seq_MCF-7_Human1.67231557
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64326068
31STAT1_20625510_ChIP-Seq_HELA_Human1.62851649
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60943491
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60276134
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58428772
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58227130
36* STAT3_23295773_ChIP-Seq_U87_Human1.56347393
37* TP63_23658742_ChIP-Seq_EP156T_Human1.55118445
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53791949
39RAC3_21632823_ChIP-Seq_H3396_Human1.51387747
40GBX2_23144817_ChIP-Seq_PC3_Human1.50058932
41CEBPB_22108803_ChIP-Seq_LS180_Human1.48001095
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47897354
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.47688082
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.47587845
45KLF5_25053715_ChIP-Seq_YYC3_Human1.46592164
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45642974
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45362374
48HOXB7_26014856_ChIP-Seq_BT474_Human1.44476797
49* ATF3_27146783_Chip-Seq_COLON_Human1.44266750
50TAF15_26573619_Chip-Seq_HEK293_Human1.43752921
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40668923
52OCT4_20526341_ChIP-Seq_ESCs_Human1.40656734
53NANOG_20526341_ChIP-Seq_ESCs_Human1.40104217
54NANOG_19829295_ChIP-Seq_ESCs_Human1.39957122
55SOX2_19829295_ChIP-Seq_ESCs_Human1.39957122
56TP53_22127205_ChIP-Seq_IMR90_Human1.38904719
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38082530
58AR_25329375_ChIP-Seq_VCAP_Human1.37278911
59OCT1_27270436_Chip-Seq_PROSTATE_Human1.37190365
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37011740
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33781203
62P53_21459846_ChIP-Seq_SAOS-2_Human1.33051104
63CBP_21632823_ChIP-Seq_H3396_Human1.33036908
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32251447
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31935683
66MYC_19829295_ChIP-Seq_ESCs_Human1.29108816
67TP63_22573176_ChIP-Seq_HFKS_Human1.28637502
68GATA4_25053715_ChIP-Seq_YYC3_Human1.27503513
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27370289
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.27075421
71TCF4_23295773_ChIP-Seq_U87_Human1.25878554
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24781579
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23819180
74TAF2_19829295_ChIP-Seq_ESCs_Human1.23043640
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21549705
76SMAD4_21799915_ChIP-Seq_A2780_Human1.21050402
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20588211
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18419426
79* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17354443
80* FOXA1_25329375_ChIP-Seq_VCAP_Human1.17354443
81CDX2_22108803_ChIP-Seq_LS180_Human1.15023050
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14813474
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.14693603
84* ERA_21632823_ChIP-Seq_H3396_Human1.13651015
85CSB_26484114_Chip-Seq_FIBROBLAST_Human1.13206201
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.09628665
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08304892
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.07931208
89BRD4_25478319_ChIP-Seq_HGPS_Human1.06478128
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.05399910
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02830067
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.02328396
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.01109238
94FUS_26573619_Chip-Seq_HEK293_Human0.99275873
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.98542265
96RXR_22108803_ChIP-Seq_LS180_Human0.96920224
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96579564
98PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.94496859
99RUNX1_27514584_Chip-Seq_MCF-7_Human0.93883029
100* E2F1_20622854_ChIP-Seq_HELA_Human0.92831363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.65709743
2MP0002837_dystrophic_cardiac_calcinosis5.65506954
3MP0003136_yellow_coat_color5.03907027
4MP0002653_abnormal_ependyma_morphology4.55217971
5MP0005171_absent_coat_pigmentation3.95587820
6MP0003879_abnormal_hair_cell3.86044180
7MP0005670_abnormal_white_adipose3.83392587
8MP0003045_fibrosis3.83177138
9MP0003950_abnormal_plasma_membrane3.78071337
10MP0003646_muscle_fatigue3.53509199
11MP0003890_abnormal_embryonic-extraembry2.51480105
12MP0000749_muscle_degeneration2.46821769
13MP0003878_abnormal_ear_physiology2.37234885
14MP0005377_hearing/vestibular/ear_phenot2.37234885
15MP0002138_abnormal_hepatobiliary_system2.05810175
16MP0003698_abnormal_male_reproductive1.95351962
17MP0002269_muscular_atrophy1.88906063
18MP0004233_abnormal_muscle_weight1.84967905
19MP0002168_other_aberrant_phenotype1.84826415
20MP0001501_abnormal_sleep_pattern1.84363122
21MP0000678_abnormal_parathyroid_gland1.76171886
22MP0005451_abnormal_body_composition1.70174828
23MP0001929_abnormal_gametogenesis1.68525110
24MP0000751_myopathy1.68061886
25MP0005395_other_phenotype1.55126221
26MP0005085_abnormal_gallbladder_physiolo1.50623315
27MP0001348_abnormal_lacrimal_gland1.49717231
28MP0009053_abnormal_anal_canal1.43427177
29MP0003718_maternal_effect1.42435075
30MP0002332_abnormal_exercise_endurance1.42371927
31MP0000762_abnormal_tongue_morphology1.34326294
32MP0004381_abnormal_hair_follicle1.32667473
33MP0000579_abnormal_nail_morphology1.30440966
34MP0000534_abnormal_ureter_morphology1.24497916
35MP0005083_abnormal_biliary_tract1.23934309
36MP0009764_decreased_sensitivity_to1.14472601
37MP0002234_abnormal_pharynx_morphology1.13042653
38MP0004272_abnormal_basement_membrane1.11805397
39MP0005423_abnormal_somatic_nervous1.10089156
40MP0002161_abnormal_fertility/fecundity1.07380075
41MP0002160_abnormal_reproductive_system1.06811742
42MP0002796_impaired_skin_barrier0.98579162
43MP0000569_abnormal_digit_pigmentation0.97999759
44MP0003195_calcinosis0.97515962
45MP0002060_abnormal_skin_morphology0.96750827
46MP0000750_abnormal_muscle_regeneration0.96729419
47MP0002210_abnormal_sex_determination0.96726945
48MP0009780_abnormal_chondrocyte_physiolo0.95478269
49MP0000427_abnormal_hair_cycle0.94943038
50MP0002938_white_spotting0.91126143
51MP0000467_abnormal_esophagus_morphology0.86217789
52MP0010352_gastrointestinal_tract_polyps0.84681141
53MP0001873_stomach_inflammation0.83440140
54MP0003137_abnormal_impulse_conducting0.83337800
55MP0003705_abnormal_hypodermis_morpholog0.80631177
56MP0010771_integument_phenotype0.79268953
57MP0001968_abnormal_touch/_nociception0.77831481
58MP0004957_abnormal_blastocyst_morpholog0.73348541
59MP0001984_abnormal_olfaction0.72722603
60MP0005551_abnormal_eye_electrophysiolog0.71955396
61MP0003806_abnormal_nucleotide_metabolis0.71222879
62MP0001216_abnormal_epidermal_layer0.70716144
63MP0010234_abnormal_vibrissa_follicle0.68675140
64MP0002876_abnormal_thyroid_physiology0.66840573
65MP0003943_abnormal_hepatobiliary_system0.65866264
66MP0002282_abnormal_trachea_morphology0.65501516
67MP0003300_gastrointestinal_ulcer0.64143843
68MP0002095_abnormal_skin_pigmentation0.62943460
69MP0000358_abnormal_cell_content/0.61915316
70MP0005266_abnormal_metabolism0.61521451
71MP0003453_abnormal_keratinocyte_physiol0.61495429
72MP0005360_urolithiasis0.61455524
73MP0002132_abnormal_respiratory_system0.61107985
74MP0005501_abnormal_skin_physiology0.60748870
75MP0002254_reproductive_system_inflammat0.60541583
76MP0000681_abnormal_thyroid_gland0.60115926
77MP0008770_decreased_survivor_rate0.58526593
78MP0002272_abnormal_nervous_system0.58423865
79MP0001145_abnormal_male_reproductive0.58308667
80MP0009115_abnormal_fat_cell0.57808483
81MP0003638_abnormal_response/metabolism_0.57250205
82MP0000653_abnormal_sex_gland0.54856923
83MP0001765_abnormal_ion_homeostasis0.54119970
84MP0005408_hypopigmentation0.53349934
85MP0000613_abnormal_salivary_gland0.50199380
86MP0005365_abnormal_bile_salt0.50024099
87MP0005023_abnormal_wound_healing0.49526716
88MP0005319_abnormal_enzyme/_coenzyme0.49162754
89MP0002928_abnormal_bile_duct0.48963913
90MP0003315_abnormal_perineum_morphology0.48706235
91MP0005389_reproductive_system_phenotype0.48217318
92MP0000470_abnormal_stomach_morphology0.47523767
93MP0008789_abnormal_olfactory_epithelium0.47505306
94MP0004510_myositis0.47494836
95MP0010678_abnormal_skin_adnexa0.47382058
96MP0009046_muscle_twitch0.47055537
97MP0003936_abnormal_reproductive_system0.47033986
98MP0002971_abnormal_brown_adipose0.46498786
99MP0002733_abnormal_thermal_nociception0.46399884
100MP0005666_abnormal_adipose_tissue0.46387492

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)6.89003268
2Focal motor seizures (HP:0011153)4.86889597
3Neonatal respiratory distress (HP:0002643)4.77617091
4Severe visual impairment (HP:0001141)4.76629384
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.34782939
6Milia (HP:0001056)3.96471250
7Bilateral sensorineural hearing impairment (HP:0008619)3.81074194
8Congenital ichthyosiform erythroderma (HP:0007431)3.70848118
9Parakeratosis (HP:0001036)3.41434035
10Attenuation of retinal blood vessels (HP:0007843)3.40681835
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.39463825
12Absent/shortened dynein arms (HP:0200106)3.39463825
13Thick nail (HP:0001805)3.27049405
14Pancreatic cysts (HP:0001737)3.26047461
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.26016636
16Bony spicule pigmentary retinopathy (HP:0007737)3.24109317
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.23524271
18Polydipsia (HP:0001959)3.20829831
19Abnormal drinking behavior (HP:0030082)3.20829831
20Conjugated hyperbilirubinemia (HP:0002908)3.13049293
21Abnormality of macular pigmentation (HP:0008002)3.07438054
22Difficulty walking (HP:0002355)3.00748550
23Chronic hepatic failure (HP:0100626)2.96863085
24Urethral obstruction (HP:0000796)2.91518198
25Acanthocytosis (HP:0001927)2.87858977
26Potter facies (HP:0002009)2.85905029
27Facial shape deformation (HP:0011334)2.85905029
28Tubular atrophy (HP:0000092)2.78762313
29Thyroid-stimulating hormone excess (HP:0002925)2.78462405
30Focal segmental glomerulosclerosis (HP:0000097)2.77971136
31Right ventricular cardiomyopathy (HP:0011663)2.76002343
32Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.74841865
33Atrophic scars (HP:0001075)2.71399019
34Renal tubular acidosis (HP:0001947)2.65240313
35Abnormal respiratory motile cilium physiology (HP:0012261)2.63688561
36Plantar hyperkeratosis (HP:0007556)2.62165916
37Tetany (HP:0001281)2.60706646
38Abnormal ciliary motility (HP:0012262)2.57076414
39Abnormality of the renal medulla (HP:0100957)2.49833862
40Alopecia of scalp (HP:0002293)2.49516873
41Male infertility (HP:0003251)2.48892776
42Dialeptic seizures (HP:0011146)2.48727705
43Febrile seizures (HP:0002373)2.47773529
44Horizontal nystagmus (HP:0000666)2.45754750
45Onycholysis (HP:0001806)2.43471911
46Severe muscular hypotonia (HP:0006829)2.41832537
47Hypokinesia (HP:0002375)2.37528853
48Polyuria (HP:0000103)2.33515118
49Nephronophthisis (HP:0000090)2.33382289
50Flattened epiphyses (HP:0003071)2.33044528
51Stage 5 chronic kidney disease (HP:0003774)2.29012935
52Hypoalbuminemia (HP:0003073)2.28901187
53Abnormal albumin level (HP:0012116)2.28901187
54Cerebellar dysplasia (HP:0007033)2.28695771
55Ulnar bowing (HP:0003031)2.24217987
56Glomerulosclerosis (HP:0000096)2.24052697
57Portal hypertension (HP:0001409)2.22276592
58Abnormality of the renal cortex (HP:0011035)2.22200977
59Tubulointerstitial fibrosis (HP:0005576)2.21168468
60Enlarged epiphyses (HP:0010580)2.16944804
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.15671485
62Pendular nystagmus (HP:0012043)2.14924814
63Upper limb muscle weakness (HP:0003484)2.14900709
64Hyperkalemia (HP:0002153)2.14034156
65Ileus (HP:0002595)2.11709902
66Poikiloderma (HP:0001029)2.10239839
67Abnormal respiratory motile cilium morphology (HP:0005938)2.08667721
68Abnormal respiratory epithelium morphology (HP:0012253)2.08667721
69Abnormal urine output (HP:0012590)2.07653646
70Tubulointerstitial abnormality (HP:0001969)2.06645647
71Palmoplantar hyperkeratosis (HP:0000972)2.05224853
72Abnormality of the hepatic vasculature (HP:0006707)2.03167415
73Nephrocalcinosis (HP:0000121)2.02274916
74Fragile nails (HP:0001808)2.01254263
75Fatigable weakness (HP:0003473)2.01152257
76Abnormality of the neuromuscular junction (HP:0003398)2.01152257
77Dehydration (HP:0001944)2.00553149
78Focal seizures (HP:0007359)1.98652466
79Aplastic anemia (HP:0001915)1.97896046
80Volvulus (HP:0002580)1.96278793
81Nasal polyposis (HP:0100582)1.94340956
82Inability to walk (HP:0002540)1.93035702
83Vertebral arch anomaly (HP:0008438)1.92449926
84Chronic bronchitis (HP:0004469)1.90092699
85Palmar hyperkeratosis (HP:0010765)1.88716955
86Bell-shaped thorax (HP:0001591)1.87843855
87Gaze-evoked nystagmus (HP:0000640)1.87605120
88Asymmetric septal hypertrophy (HP:0001670)1.86691469
89Type II lissencephaly (HP:0007260)1.86071376
90Infertility (HP:0000789)1.80504635
91Abnormality of renal excretion (HP:0011036)1.79462387
92Renovascular hypertension (HP:0100817)1.78302109
93Subcapsular cataract (HP:0000523)1.77687962
94Radial bowing (HP:0002986)1.77663256
95Cystic liver disease (HP:0006706)1.77140636
96Enlarged kidneys (HP:0000105)1.76814499
97Polar cataract (HP:0010696)1.76434757
98Fibular aplasia (HP:0002990)1.72648222
99Absent epiphyses (HP:0010577)1.72445220
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72445220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.54737966
2STK38L5.78646180
3LATS25.22142562
4EPHA24.18964515
5NEK13.38238723
6STK383.37021252
7MST1R2.82692446
8FRK2.73639371
9PLK42.61493199
10PRKD32.52284385
11IRAK32.51294731
12NEK22.44697681
13TESK11.88410570
14INSRR1.82629714
15STK31.75911374
16ZAK1.61242819
17MET1.51664757
18MAP3K91.34874374
19ADRBK21.30545362
20PTK2B1.13891691
21BMPR1B1.06844344
22MAP2K21.06710093
23NME21.03729199
24LMTK21.03167080
25MELK1.01036383
26MOS0.96711876
27KSR20.94559603
28PIK3CG0.94359801
29MAP4K20.88565352
30PDPK10.85244889
31PLK20.77920869
32DDR20.77681926
33ADRBK10.75748465
34ACVR1B0.73870298
35ARAF0.70934362
36PTK20.68371035
37MST40.67800031
38MAP3K20.66984110
39LIMK10.64041353
40NEK60.63599483
41STK100.63422157
42PAK40.58605894
43PRKCI0.57203680
44PRKAA20.57134421
45ERBB40.56242141
46TGFBR20.48058553
47MAP2K10.47993927
48STK390.45102506
49TGFBR10.43828187
50MAPK150.42543560
51NME10.41655971
52CSNK1A1L0.41003353
53CDK80.40375229
54TAF10.39419480
55EIF2AK30.38847665
56PIM20.37514457
57CDK70.36705021
58EPHB20.34701990
59MAP3K80.33741284
60AKT30.33049103
61CDK120.32920695
62MAP3K120.32450103
63SIK20.31406692
64PBK0.30865152
65MAP3K30.30474259
66BCR0.29988573
67MKNK20.27881787
68BRAF0.27195809
69FLT30.26975228
70PRKG20.26655234
71GRK70.24087694
72BUB10.23858331
73TRIM280.23456206
74AKT20.23439971
75ERN10.22904214
76CAMK2A0.22805563
77PLK10.22757138
78NLK0.22451061
79DAPK10.22414449
80FER0.20898800
81PRKCE0.20608268
82WNK40.19470367
83MAP2K70.17410190
84PAK10.16286645
85NTRK10.15859740
86PNCK0.15211828
87PDK10.14552490
88ABL20.12650228
89VRK20.12434744
90CSNK1A10.11537322
91CHEK20.11493481
92AURKA0.10609072
93BMX0.10202209
94PDK20.09740826
95STK240.09717801
96CAMK2G0.09470250
97PRKD10.09294952
98OXSR10.08501056
99NEK90.08440915
100CHUK0.08289273

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.55885892
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.55963309
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.37190904
4Sphingolipid metabolism_Homo sapiens_hsa006003.33307004
5Phototransduction_Homo sapiens_hsa047443.28754135
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.05287305
7Fatty acid biosynthesis_Homo sapiens_hsa000612.86533110
8Dorso-ventral axis formation_Homo sapiens_hsa043202.10731251
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02949739
10Taste transduction_Homo sapiens_hsa047422.00618571
11N-Glycan biosynthesis_Homo sapiens_hsa005101.98628054
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98603722
13Phenylalanine metabolism_Homo sapiens_hsa003601.95455244
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.94675296
15Olfactory transduction_Homo sapiens_hsa047401.84399100
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79089041
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73062998
18Salivary secretion_Homo sapiens_hsa049701.72731525
19ECM-receptor interaction_Homo sapiens_hsa045121.70968437
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67394781
21Sulfur relay system_Homo sapiens_hsa041221.61790557
22Nitrogen metabolism_Homo sapiens_hsa009101.61477935
23Basal transcription factors_Homo sapiens_hsa030221.50856926
24Nicotine addiction_Homo sapiens_hsa050331.43885911
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35516724
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24848281
27Butanoate metabolism_Homo sapiens_hsa006501.20160871
28ABC transporters_Homo sapiens_hsa020101.14634300
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.14035808
30Glycerolipid metabolism_Homo sapiens_hsa005611.11269749
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02871341
32Hippo signaling pathway_Homo sapiens_hsa043901.01472360
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.00984043
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.00949625
35Adherens junction_Homo sapiens_hsa045200.99796233
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98853844
37Morphine addiction_Homo sapiens_hsa050320.90229085
38One carbon pool by folate_Homo sapiens_hsa006700.89043950
39Purine metabolism_Homo sapiens_hsa002300.88764354
40Calcium signaling pathway_Homo sapiens_hsa040200.88332509
41Thyroid cancer_Homo sapiens_hsa052160.87014826
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85472880
43Tight junction_Homo sapiens_hsa045300.84597518
44Histidine metabolism_Homo sapiens_hsa003400.83430868
45Dilated cardiomyopathy_Homo sapiens_hsa054140.82072204
46Arginine and proline metabolism_Homo sapiens_hsa003300.81561437
47Tryptophan metabolism_Homo sapiens_hsa003800.80673005
48Pyrimidine metabolism_Homo sapiens_hsa002400.79551697
49Focal adhesion_Homo sapiens_hsa045100.79177149
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.76790672
51Tyrosine metabolism_Homo sapiens_hsa003500.75857974
52Glutathione metabolism_Homo sapiens_hsa004800.71220929
53Homologous recombination_Homo sapiens_hsa034400.70530078
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69688622
55p53 signaling pathway_Homo sapiens_hsa041150.69660183
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69611484
57RNA transport_Homo sapiens_hsa030130.66851179
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64758136
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.64657457
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58956241
61RNA polymerase_Homo sapiens_hsa030200.58640163
62VEGF signaling pathway_Homo sapiens_hsa043700.58009262
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56492389
64Selenocompound metabolism_Homo sapiens_hsa004500.56446085
65African trypanosomiasis_Homo sapiens_hsa051430.56243836
66Metabolic pathways_Homo sapiens_hsa011000.55155491
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50287220
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.49687619
69Small cell lung cancer_Homo sapiens_hsa052220.49144278
70Ovarian steroidogenesis_Homo sapiens_hsa049130.48320540
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47153067
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47091654
73Glutamatergic synapse_Homo sapiens_hsa047240.45887428
74Bile secretion_Homo sapiens_hsa049760.45859520
75TGF-beta signaling pathway_Homo sapiens_hsa043500.42931618
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42743945
77Starch and sucrose metabolism_Homo sapiens_hsa005000.40112201
78Biosynthesis of amino acids_Homo sapiens_hsa012300.39497279
79Serotonergic synapse_Homo sapiens_hsa047260.38951767
80Pancreatic cancer_Homo sapiens_hsa052120.36067251
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35596854
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35402701
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.35239721
84Inositol phosphate metabolism_Homo sapiens_hsa005620.34458106
85Estrogen signaling pathway_Homo sapiens_hsa049150.33718193
86Retinol metabolism_Homo sapiens_hsa008300.28212072
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24760512
88Linoleic acid metabolism_Homo sapiens_hsa005910.24612222
89Cell cycle_Homo sapiens_hsa041100.24534658
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24140393
91cAMP signaling pathway_Homo sapiens_hsa040240.22603349
92Fatty acid degradation_Homo sapiens_hsa000710.20407300
93Chemical carcinogenesis_Homo sapiens_hsa052040.19649176
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.19590650
95MicroRNAs in cancer_Homo sapiens_hsa052060.19193070
96Nucleotide excision repair_Homo sapiens_hsa034200.18030067
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.17406877
98Mineral absorption_Homo sapiens_hsa049780.16809642
99Arachidonic acid metabolism_Homo sapiens_hsa005900.15273751
100Galactose metabolism_Homo sapiens_hsa000520.15267733

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