MYH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle atrophy (GO:0014889)9.76863362
2response to stimulus involved in regulation of muscle adaptation (GO:0014874)9.69851535
3* muscle filament sliding (GO:0030049)9.28036269
4* actin-myosin filament sliding (GO:0033275)9.28036269
5positive regulation of myoblast differentiation (GO:0045663)8.96556224
6* skeletal muscle contraction (GO:0003009)8.91026494
7plasma membrane repair (GO:0001778)8.86945993
8multicellular organismal movement (GO:0050879)8.71692376
9musculoskeletal movement (GO:0050881)8.71692376
10positive regulation of skeletal muscle tissue development (GO:0048643)8.34928827
11myoblast fusion (GO:0007520)7.79092518
12* actin-mediated cell contraction (GO:0070252)7.66186150
13response to muscle activity (GO:0014850)7.47024949
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.32282748
15muscle cell cellular homeostasis (GO:0046716)6.98239966
16syncytium formation by plasma membrane fusion (GO:0000768)6.98110503
17positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)6.92648928
18cellular response to estradiol stimulus (GO:0071392)6.87189352
19muscle fiber development (GO:0048747)6.73959965
20myotube differentiation (GO:0014902)6.55347392
21regulation of skeletal muscle contraction (GO:0014819)6.44435521
22syncytium formation (GO:0006949)6.43924369
23mRNA transcription from RNA polymerase II promoter (GO:0042789)6.05177062
24skeletal muscle tissue development (GO:0007519)5.75483947
25* actin filament-based movement (GO:0030048)5.74723812
26negative regulation of potassium ion transmembrane transport (GO:1901380)5.73403444
27positive regulation of striated muscle cell differentiation (GO:0051155)5.49790263
28striated muscle adaptation (GO:0014888)5.29331030
29sarcoplasmic reticulum calcium ion transport (GO:0070296)5.29073193
30mRNA transcription (GO:0009299)5.22882137
31cellular response to lithium ion (GO:0071285)5.17095045
32neuromuscular synaptic transmission (GO:0007274)5.06752717
33skeletal muscle tissue regeneration (GO:0043403)5.04149254
34neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.89561783
35striated muscle cell development (GO:0055002)4.85025595
36* striated muscle contraction (GO:0006941)4.79598756
37regulation of myotube differentiation (GO:0010830)4.67297882
38regulation of sarcomere organization (GO:0060297)4.67207203
39negative regulation of fatty acid transport (GO:2000192)4.57595476
40response to lithium ion (GO:0010226)4.53430495
41cellular response to estrogen stimulus (GO:0071391)4.48024197
42positive regulation of muscle cell differentiation (GO:0051149)4.47820719
43regulation of myoblast differentiation (GO:0045661)4.46252502
44plasma membrane fusion (GO:0045026)4.40731282
45muscle cell development (GO:0055001)4.38773180
46extracellular fibril organization (GO:0043206)4.33574953
47positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.28595671
48response to parathyroid hormone (GO:0071107)4.25340360
49muscle adaptation (GO:0043500)4.22949914
50negative regulation of cell size (GO:0045792)4.22091203
51regulation of relaxation of muscle (GO:1901077)4.14433602
52* muscle organ development (GO:0007517)4.09856334
53negative regulation of muscle hypertrophy (GO:0014741)4.04153079
54* muscle structure development (GO:0061061)3.98391921
55regulation of pseudopodium assembly (GO:0031272)3.97714393
56* muscle contraction (GO:0006936)3.97364320
57neuromuscular junction development (GO:0007528)3.94392475
58positive regulation of glomerulus development (GO:0090193)3.88155766
59parturition (GO:0007567)3.84471654
60striated muscle tissue development (GO:0014706)3.83545132
61* muscle system process (GO:0003012)3.79696910
62regulation of muscle adaptation (GO:0043502)3.70571421
63G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.69363781
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.66546880
65negative regulation of norepinephrine secretion (GO:0010700)3.66117277
66regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.64947403
67keratan sulfate catabolic process (GO:0042340)3.64227093
68response to caffeine (GO:0031000)3.61291164
69fibril organization (GO:0097435)3.57515937
70embryonic camera-type eye development (GO:0031076)3.54354178
71negative regulation of nitric-oxide synthase activity (GO:0051001)3.54149800
72positive regulation of protein depolymerization (GO:1901881)3.54078783
73regulation of skeletal muscle fiber development (GO:0048742)3.52606240
74negative regulation of gluconeogenesis (GO:0045721)3.49196911
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47281504
76myofibril assembly (GO:0030239)3.43901263
77regulation of skeletal muscle cell differentiation (GO:2001014)3.40078993
78regulation of muscle system process (GO:0090257)3.39638985
79* sarcomere organization (GO:0045214)3.38068175
80muscle tissue development (GO:0060537)3.35492127
81cardiac muscle cell development (GO:0055013)3.33229345
82negative regulation of protein localization to cell surface (GO:2000009)3.32444996
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.30691696
84regulation of cardiac muscle cell differentiation (GO:2000725)3.28867376
85negative regulation of cardiac muscle hypertrophy (GO:0010614)3.28008525
86regulation of striated muscle cell differentiation (GO:0051153)3.27341041
87regulation of muscle cell differentiation (GO:0051147)3.20420634
88regulation of protein heterodimerization activity (GO:0043497)3.19741284
89collagen fibril organization (GO:0030199)3.18243873
90cardiac cell development (GO:0055006)3.16560167
91regulation of p38MAPK cascade (GO:1900744)3.15739114
92regulation of muscle contraction (GO:0006937)3.15067165
93endocrine hormone secretion (GO:0060986)3.13171237
94cardiac myofibril assembly (GO:0055003)3.11181342
95regulation of calcium ion transmembrane transport (GO:1903169)3.09923895
96myoblast migration (GO:0051451)3.09494302
97regulation of skeletal muscle tissue development (GO:0048641)3.07436325
98regulation of alkaline phosphatase activity (GO:0010692)2.99907344
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99304276
100positive regulation of phosphatase activity (GO:0010922)2.98254547
101* actomyosin structure organization (GO:0031032)2.98081148
102regulation of striated muscle contraction (GO:0006942)2.97091758
103positive regulation of muscle organ development (GO:0048636)2.96421848
104positive regulation of striated muscle tissue development (GO:0045844)2.96421848
105cardiac muscle contraction (GO:0060048)2.90612845
106positive regulation of muscle tissue development (GO:1901863)2.88398408
107positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.87895464
108regulation of membrane repolarization (GO:0060306)2.87444474
109regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.85485197
110regulation of cell communication by electrical coupling (GO:0010649)2.83924896
111muscle cell differentiation (GO:0042692)2.78428179
112positive regulation of glycogen biosynthetic process (GO:0045725)2.75369187
113response to electrical stimulus (GO:0051602)2.74706712
114negative regulation of potassium ion transport (GO:0043267)2.73109018
115postsynaptic membrane organization (GO:0001941)2.64508394
116regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59654689
117neuronal action potential (GO:0019228)2.58274521
118negative regulation of heart growth (GO:0061117)2.56963234
119negative regulation of cardiac muscle tissue growth (GO:0055022)2.56963234
120regulation of potassium ion transmembrane transporter activity (GO:1901016)2.56563776
121positive regulation of protein complex disassembly (GO:0043243)2.54439220
122skeletal muscle adaptation (GO:0043501)2.53774075
123positive regulation of astrocyte differentiation (GO:0048711)2.52928088
124regulation of calcium ion transmembrane transporter activity (GO:1901019)2.47742389
125skeletal muscle fiber development (GO:0048741)13.4338277
126muscle cell fate commitment (GO:0042693)13.3513941
127positive regulation of myotube differentiation (GO:0010831)11.8726418
128response to inactivity (GO:0014854)11.6431533
129myotube cell development (GO:0014904)11.4214524
130striated muscle atrophy (GO:0014891)11.1745060
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)10.8244373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.98237184
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.06587810
3ESR1_20079471_ChIP-ChIP_T-47D_Human5.03345841
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.96506251
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.88688186
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40733635
7EZH2_22144423_ChIP-Seq_EOC_Human3.38714074
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.28824944
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.69452187
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.56422254
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29874372
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26097753
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.22097151
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.18386081
15* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.17308340
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11173864
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09219054
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.08972916
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05384756
20MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.03205450
21CLOCK_20551151_ChIP-Seq_293T_Human1.96927292
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96757339
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96270672
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.94831471
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.92296774
26TBX20_22328084_ChIP-Seq_HEART_Mouse1.92296774
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92091735
28GATA1_22025678_ChIP-Seq_K562_Human1.92044342
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.87484522
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80902058
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79303120
32LXR_22292898_ChIP-Seq_THP-1_Human1.75696207
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74789431
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66967488
35ZNF263_19887448_ChIP-Seq_K562_Human1.62834838
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59744840
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.59127239
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.57352246
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.56434617
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55912669
41KDM2B_26808549_Chip-Seq_DND41_Human1.49956931
42* EZH2_27294783_Chip-Seq_ESCs_Mouse1.47443322
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46976703
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.40137572
45GBX2_23144817_ChIP-Seq_PC3_Human1.39642984
46ZNF274_21170338_ChIP-Seq_K562_Hela1.38371044
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38356563
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37808203
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36905641
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36413686
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35954871
52KDM2B_26808549_Chip-Seq_K562_Human1.35806440
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32136495
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32136495
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32090791
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31742561
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30866594
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30764134
59IGF1R_20145208_ChIP-Seq_DFB_Human1.27469353
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.27095109
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26855768
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25818114
63ATF3_27146783_Chip-Seq_COLON_Human1.25388659
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.24247431
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21886242
66DROSHA_22980978_ChIP-Seq_HELA_Human1.21669618
67RACK7_27058665_Chip-Seq_MCF-7_Human1.21260747
68KDM2B_26808549_Chip-Seq_REH_Human1.21216991
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.20848798
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18534056
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18486318
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18038497
73CJUN_26792858_Chip-Seq_BT549_Human1.17926684
74CTCF_21964334_Chip-Seq_Bcells_Human1.17696498
75TP53_16413492_ChIP-PET_HCT116_Human1.16773137
76TP53_22127205_ChIP-Seq_IMR90_Human1.15496910
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13997258
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.12597154
79TCF7_22412390_ChIP-Seq_EML_Mouse1.12379081
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11760813
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10365588
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10117868
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09696575
84SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09187889
85* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08476455
86* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07687468
87CTCF_27219007_Chip-Seq_Bcells_Human1.06049949
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05221103
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04941154
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04849340
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04354414
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03322883
93* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03246089
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03190890
95TP53_18474530_ChIP-ChIP_U2OS_Human1.02607446
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01725461
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.00903548
98* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98864248
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98602763
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98356101
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.96822949
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.96525478
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96417703
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.95008129
105SMAD4_21799915_ChIP-Seq_A2780_Human0.94647520
106CBX2_27304074_Chip-Seq_ESCs_Mouse0.94214687
107BRD4_25478319_ChIP-Seq_HGPS_Human0.93873738
108AHR_22903824_ChIP-Seq_MCF-7_Human0.93695073
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93538154
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93412143
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.93344317
112GATA1_19941826_ChIP-Seq_K562_Human0.93110375
113* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92655337
114P53_22387025_ChIP-Seq_ESCs_Mouse0.92487858
115* NFI_21473784_ChIP-Seq_ESCs_Mouse0.92229193
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.91855208
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91472375
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91364923
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90542804
120RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90285147
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90269099
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89626831
123NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89454865
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89376365
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89321668
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.88800050
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88675798
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88462434
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87243382
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87180447
131CREB1_26743006_Chip-Seq_LNCaP_Human0.87110859
132AR_19668381_ChIP-Seq_PC3_Human0.85068456
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.84995176
134ZFX_18555785_Chip-Seq_ESCs_Mouse0.84616219
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84405826
136RNF2_27304074_Chip-Seq_ESCs_Mouse0.83753332
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83613394
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83609787
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.83381598
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.83343461
141* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83331283
142ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83200299
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83036001
144PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82922197
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82739637
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81859726
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81152452
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81152452
149SOX2_20726797_ChIP-Seq_SW620_Human0.80948879
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80728103
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80557130
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.80089016
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80040856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia6.95039777
2MP0000733_abnormal_muscle_development6.12144337
3MP0000749_muscle_degeneration5.85457661
4MP0000751_myopathy5.23620626
5MP0000750_abnormal_muscle_regeneration5.19423309
6MP0000747_muscle_weakness4.32041816
7MP0004145_abnormal_muscle_electrophysio3.75958234
8MP0000759_abnormal_skeletal_muscle3.64904021
9MP0002106_abnormal_muscle_physiology3.59633771
10MP0001542_abnormal_bone_strength3.55093175
11MP0004087_abnormal_muscle_fiber3.30046512
12MP0009780_abnormal_chondrocyte_physiolo2.98646554
13MP0005369_muscle_phenotype2.92067741
14MP0003950_abnormal_plasma_membrane2.76345730
15MP0002837_dystrophic_cardiac_calcinosis2.63920102
16MP0002269_muscular_atrophy2.63485046
17MP0002249_abnormal_larynx_morphology2.54914112
18MP0002971_abnormal_brown_adipose2.41866676
19MP0002108_abnormal_muscle_morphology2.35299640
20MP0004084_abnormal_cardiac_muscle2.31672532
21MP0004233_abnormal_muscle_weight2.18385426
22MP0005623_abnormal_meninges_morphology2.16561281
23MP0002734_abnormal_mechanical_nocicepti2.12313088
24MP0003941_abnormal_skin_development2.08116210
25MP0004036_abnormal_muscle_relaxation1.78598394
26MP0005330_cardiomyopathy1.70979491
27MP0005620_abnormal_muscle_contractility1.70965589
28MP0001299_abnormal_eye_distance/1.58443536
29MP0004215_abnormal_myocardial_fiber1.57303040
30MP0002163_abnormal_gland_morphology1.51624448
31MP0010030_abnormal_orbit_morphology1.49204847
32MP0010630_abnormal_cardiac_muscle1.33806185
33MP0001958_emphysema1.25548354
34MP0002972_abnormal_cardiac_muscle1.20113585
35MP0003879_abnormal_hair_cell1.18903853
36MP0008438_abnormal_cutaneous_collagen1.18086087
37MP0002877_abnormal_melanocyte_morpholog1.17544365
38MP0010368_abnormal_lymphatic_system1.15399565
39MP0003121_genomic_imprinting1.02841447
40MP0003115_abnormal_respiratory_system1.02547222
41MP0006276_abnormal_autonomic_nervous0.98138230
42MP0002114_abnormal_axial_skeleton0.97090337
43MP0005248_abnormal_Harderian_gland0.96377166
44MP0003137_abnormal_impulse_conducting0.93358759
45MP0002060_abnormal_skin_morphology0.92250253
46MP0003385_abnormal_body_wall0.92160543
47MP0003646_muscle_fatigue0.91160038
48MP0001346_abnormal_lacrimal_gland0.86851496
49MP0002127_abnormal_cardiovascular_syste0.82996727
50MP0003566_abnormal_cell_adhesion0.82665648
51MP0005503_abnormal_tendon_morphology0.82361882
52MP0005595_abnormal_vascular_smooth0.79945053
53MP0003705_abnormal_hypodermis_morpholog0.78687389
54MP0002184_abnormal_innervation0.78252169
55MP0003122_maternal_imprinting0.77804950
56MP0001943_abnormal_respiration0.76512698
57MP0004484_altered_response_of0.75015102
58MP0004130_abnormal_muscle_cell0.72161872
59MP0003091_abnormal_cell_migration0.71701482
60MP0009250_abnormal_appendicular_skeleto0.71500096
61MP0005379_endocrine/exocrine_gland_phen0.63468474
62MP0004272_abnormal_basement_membrane0.63326444
63MP0003948_abnormal_gas_homeostasis0.62964667
64MP0003279_aneurysm0.62959937
65MP0002234_abnormal_pharynx_morphology0.61755715
66MP0000516_abnormal_urinary_system0.60904789
67MP0005367_renal/urinary_system_phenotyp0.60904789
68MP0001661_extended_life_span0.58888505
69MP0005275_abnormal_skin_tensile0.58635197
70MP0004510_myositis0.58425123
71MP0004197_abnormal_fetal_growth/weight/0.57750730
72MP0003828_pulmonary_edema0.57725704
73MP0000013_abnormal_adipose_tissue0.55610552
74MP0003045_fibrosis0.55525444
75MP0000955_abnormal_spinal_cord0.55433512
76MP0003942_abnormal_urinary_system0.55239690
77MP0002822_catalepsy0.53270442
78MP0003755_abnormal_palate_morphology0.52029902
79MP0005451_abnormal_body_composition0.51064208
80MP0000767_abnormal_smooth_muscle0.50536032
81MP0002932_abnormal_joint_morphology0.50280611
82MP0000372_irregular_coat_pigmentation0.49318224
83MP0003959_abnormal_lean_body0.49269134
84MP0009384_cardiac_valve_regurgitation0.48838482
85MP0000428_abnormal_craniofacial_morphol0.48634096
86MP0002081_perinatal_lethality0.48521960
87MP0005266_abnormal_metabolism0.48034845
88MP0005385_cardiovascular_system_phenoty0.45931072
89MP0001544_abnormal_cardiovascular_syste0.45931072
90MP0005257_abnormal_intraocular_pressure0.45131671
91MP0005452_abnormal_adipose_tissue0.44494182
92MP0004858_abnormal_nervous_system0.44218925
93MP0005508_abnormal_skeleton_morphology0.42638733
94MP0001243_abnormal_dermal_layer0.41732837
95MP0004264_abnormal_extraembryonic_tissu0.41133548
96MP0000266_abnormal_heart_morphology0.40407943
97MP0006138_congestive_heart_failure0.39533651
98MP0001986_abnormal_taste_sensitivity0.39438685
99MP0000003_abnormal_adipose_tissue0.39351165
100MP0002933_joint_inflammation0.39302881
101MP0002113_abnormal_skeleton_development0.38598247
102MP0005165_increased_susceptibility_to0.37993001
103MP0002115_abnormal_skeleton_extremities0.37871699
104MP0005076_abnormal_cell_differentiation0.37649065
105MP0004085_abnormal_heartbeat0.37101386
106MP0000762_abnormal_tongue_morphology0.36260529
107MP0002116_abnormal_craniofacial_bone0.35898840
108MP0000858_altered_metastatic_potential0.35810043
109MP0003567_abnormal_fetal_cardiomyocyte0.35432834
110MP0002896_abnormal_bone_mineralization0.35261267
111MP0001784_abnormal_fluid_regulation0.35203815
112MP0002089_abnormal_postnatal_growth/wei0.34839876
113MP0003300_gastrointestinal_ulcer0.34783517
114MP0000432_abnormal_head_morphology0.34629532
115MP0004134_abnormal_chest_morphology0.34538833
116MP0003935_abnormal_craniofacial_develop0.34365773
117MP0002332_abnormal_exercise_endurance0.34212773
118MP0001614_abnormal_blood_vessel0.34183849
119MP0002128_abnormal_blood_circulation0.33912808
120MP0005319_abnormal_enzyme/_coenzyme0.33573699
121MP0002109_abnormal_limb_morphology0.32758522
122MP0000343_altered_response_to0.31504502
123MP0001915_intracranial_hemorrhage0.29765967
124MP0002066_abnormal_motor_capabilities/c0.25821178
125MP0001849_ear_inflammation0.24836940
126MP0000534_abnormal_ureter_morphology0.24277783
127MP0005375_adipose_tissue_phenotype0.24259247
128MP0002233_abnormal_nose_morphology0.23838003

Predicted human phenotypes

RankGene SetZ-score
1Fetal akinesia sequence (HP:0001989)9.65756636
2Popliteal pterygium (HP:0009756)9.05467387
3Aplasia of the musculature (HP:0100854)8.33789180
4Abnormality of placental membranes (HP:0011409)7.97883528
5Amniotic constriction ring (HP:0009775)7.97883528
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.79438716
7Muscle fiber inclusion bodies (HP:0100299)7.11809847
8Nemaline bodies (HP:0003798)7.08765239
9Akinesia (HP:0002304)6.97823608
10Type 2 muscle fiber atrophy (HP:0003554)6.66101097
11Type 1 muscle fiber predominance (HP:0003803)6.25423081
12Muscle fiber atrophy (HP:0100295)6.02613687
13Abnormality of the neuromuscular junction (HP:0003398)5.68676406
14Fatigable weakness (HP:0003473)5.68676406
15* Malignant hyperthermia (HP:0002047)5.65394791
16Weak cry (HP:0001612)5.36539475
17Aplasia/Hypoplasia involving the musculature (HP:0001460)5.00840075
18Pterygium (HP:0001059)4.85137059
19Thin ribs (HP:0000883)4.80108460
20Myopathic facies (HP:0002058)4.68671406
21Muscle fiber splitting (HP:0003555)4.66116693
22Bulbar palsy (HP:0001283)4.64499682
23Gowers sign (HP:0003391)4.64449776
24* Distal arthrogryposis (HP:0005684)4.64298931
25Difficulty running (HP:0009046)4.62009881
26Hypoplastic heart (HP:0001961)4.33905322
27Difficulty climbing stairs (HP:0003551)4.27213679
28Easy fatigability (HP:0003388)4.09755577
29Calf muscle hypertrophy (HP:0008981)4.05527915
30Abnormality of the calf musculature (HP:0001430)4.00566786
31Cystic hygroma (HP:0000476)3.89206336
32Mildly elevated creatine phosphokinase (HP:0008180)3.82637978
33EMG: myopathic abnormalities (HP:0003458)3.72172505
34Muscle hypertrophy of the lower extremities (HP:0008968)3.60221083
35Diminished movement (HP:0002374)3.47379771
36Abnormality of skeletal muscle fiber size (HP:0012084)3.32656434
37Hyporeflexia of lower limbs (HP:0002600)3.28346665
38Generalized muscle weakness (HP:0003324)3.26299079
39Long clavicles (HP:0000890)3.18240865
40Abnormalities of placenta or umbilical cord (HP:0001194)3.16434866
41* Round ear (HP:0100830)3.13949358
42Poor suck (HP:0002033)3.06941274
43Centrally nucleated skeletal muscle fibers (HP:0003687)3.05578219
44Slender build (HP:0001533)2.92963628
45Exercise-induced myalgia (HP:0003738)2.86255456
46* Ulnar deviation of the wrist (HP:0003049)2.84815117
47* Breech presentation (HP:0001623)2.81780870
48Increased connective tissue (HP:0009025)2.74857048
49Distal lower limb amyotrophy (HP:0008944)2.74066342
50Neck muscle weakness (HP:0000467)2.73123174
51Respiratory insufficiency due to muscle weakness (HP:0002747)2.65170594
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.57961598
53Increased variability in muscle fiber diameter (HP:0003557)2.56059444
54Arthrogryposis multiplex congenita (HP:0002804)2.52661797
55Premature rupture of membranes (HP:0001788)2.50968946
56Asymmetric septal hypertrophy (HP:0001670)2.48001765
57* Absent phalangeal crease (HP:0006109)2.45268234
58Hypoplastic ischia (HP:0003175)2.43656526
59Abnormality of the left ventricular outflow tract (HP:0011103)2.38519423
60Subaortic stenosis (HP:0001682)2.38519423
61* Calcaneovalgus deformity (HP:0001848)2.35257576
62Frequent falls (HP:0002359)2.32718240
63Scapular winging (HP:0003691)2.28991979
64Fragile skin (HP:0001030)2.26988491
65Vertebral fusion (HP:0002948)2.20475367
66Neonatal respiratory distress (HP:0002643)2.18824212
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17317062
68Lower limb amyotrophy (HP:0007210)2.16788552
69Increased density of long bones (HP:0006392)2.16218846
70Exercise-induced muscle cramps (HP:0003710)2.13520528
71* Webbed neck (HP:0000465)2.12615333
72Abnormality of the ischium (HP:0003174)2.11303511
73EMG: neuropathic changes (HP:0003445)2.10979972
74Soft skin (HP:0000977)2.10756723
75Spinal rigidity (HP:0003306)2.08947560
76Aortic dissection (HP:0002647)2.08428832
77* Deformed tarsal bones (HP:0008119)2.07440824
78Vertebral clefting (HP:0008428)2.02858536
79Sudden death (HP:0001699)2.01980437
80* Abnormal finger flexion creases (HP:0006143)1.98195259
81* Rocker bottom foot (HP:0001838)1.97077897
82Facial diplegia (HP:0001349)1.94341122
83Distal upper limb amyotrophy (HP:0007149)1.91654874
84Upper limb amyotrophy (HP:0009129)1.91654874
85Bell-shaped thorax (HP:0001591)1.89814932
86* Trismus (HP:0000211)1.86649246
87Waddling gait (HP:0002515)1.86108028
88Protrusio acetabuli (HP:0003179)1.85208210
89* Hip contracture (HP:0003273)1.84672040
90Shoulder girdle muscle weakness (HP:0003547)1.82286146
91Thin bony cortex (HP:0002753)1.79765674
92Pelvic girdle muscle weakness (HP:0003749)1.79159004
93Abnormality of the hip-girdle musculature (HP:0001445)1.75453624
94Abnormality of the musculature of the pelvis (HP:0001469)1.75453624
95Abnormality of the shoulder girdle musculature (HP:0001435)1.75422848
96Atrophic scars (HP:0001075)1.75261036
97* Ulnar deviation of finger (HP:0009465)1.74344643
98Nonprogressive disorder (HP:0003680)1.73705202
99Infantile muscular hypotonia (HP:0008947)1.72545820
100Distal lower limb muscle weakness (HP:0009053)1.67549192
101Myotonia (HP:0002486)1.67272516
102Cutaneous syndactyly (HP:0012725)1.67162033
103Bladder diverticulum (HP:0000015)1.65406405
104* Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.65085754
105Limb-girdle muscle atrophy (HP:0003797)1.64807869
106Lipoatrophy (HP:0100578)1.61354471
107* Adducted thumb (HP:0001181)1.60091329
108Cerebral aneurysm (HP:0004944)1.59888582
109Short thorax (HP:0010306)1.58665199
110Neoplasm of the heart (HP:0100544)1.55133491
111Deep philtrum (HP:0002002)1.54236755
112Fused cervical vertebrae (HP:0002949)1.53235003
113Proximal amyotrophy (HP:0007126)1.50125927
114Rib fusion (HP:0000902)1.49692091
115Testicular atrophy (HP:0000029)1.47005639
116Right ventricular cardiomyopathy (HP:0011663)1.44728307
117* Metatarsus adductus (HP:0001840)1.44723256
118Limb-girdle muscle weakness (HP:0003325)1.42113446
119Hypoplastic nipples (HP:0002557)1.40642589
120Areflexia of lower limbs (HP:0002522)1.39245647
121Pulmonary hypoplasia (HP:0002089)1.37410092
122Congenital hip dislocation (HP:0001374)1.37337395
123* Abnormality of the calcaneus (HP:0008364)1.35501598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MOS8.39018880
2MUSK7.59226756
3PIK3CG5.68938849
4TRIB34.46937491
5PIM23.86693770
6CCNB13.49976486
7MAP2K12.63157739
8MAP3K102.15644401
9CDK141.98650255
10OBSCN1.97733665
11FGFR41.95987825
12CDK151.94753635
13CDK61.94277082
14CDK181.87022778
15CDK11A1.80219917
16PKN21.73846865
17PAK41.57352688
18EPHB11.52965416
19DYRK1B1.43448216
20TIE11.38083005
21MARK11.26021314
22MAPK121.19048568
23ILK1.17975349
24MAP3K51.15925429
25AKT21.13270042
26DDR21.07740207
27PTK61.05829898
28NME11.05304311
29TTN1.04305901
30RPS6KB21.03687605
31CDK190.91752198
32ICK0.88477087
33SIK10.87591925
34DAPK30.87248244
35ROCK20.85642736
36MAP3K130.84766300
37TNIK0.84232255
38PTK20.82534590
39RIPK10.77583516
40LIMK10.76601873
41ARAF0.73199653
42EPHB20.72564093
43MTOR0.72357010
44NEK90.71377918
45MAPK70.66171999
46MAPKAPK50.62103902
47LATS20.59378709
48KSR10.57695207
49CDK50.56727996
50MAP3K70.55941648
51MYLK0.55145126
52PHKG20.55123685
53PHKG10.55123685
54CAMK2A0.53888757
55PDGFRA0.53706576
56MARK20.53495649
57ROCK10.52933815
58ABL10.52527704
59LRRK20.51887459
60DMPK0.49821857
61TYRO30.48829804
62DAPK20.46612976
63ALK0.45998392
64MAPK100.45455466
65MAPKAPK30.42681888
66PDPK10.42202023
67MAPK130.40505413
68PRKD30.39938917
69RPS6KA30.39272796
70PIK3CA0.39110647
71PTK2B0.35998962
72EEF2K0.35967114
73RPS6KA20.35433802
74PBK0.35367572
75PAK30.34451709
76PRKG10.33779483
77FGFR10.31974728
78KSR20.31844370
79CDK90.31132822
80CDK80.30083449
81CAMK2D0.29817529
82STK110.29038051
83MAP3K90.28704397
84RAF10.27789457
85PDK10.27344414
86CDC42BPA0.27307079
87ERBB40.26147142
88PDK30.25467103
89PDK40.25467103
90PRKG20.24886646
91MAPK40.24512890
92PAK60.23081973
93ERN10.22988453
94BRD40.22938754
95FER0.22897169
96MAPKAPK20.22836696
97PRKACA0.22644908
98PAK20.21562652
99CAMKK10.21209175
100CAMK2G0.21029535
101KIT0.20944232
102MAPK110.20666608
103EPHA30.19968103
104RPS6KB10.19304996
105INSR0.18272813
106PRKCA0.17923893
107CSNK1G10.17848040
108RET0.17083355
109MAPK90.16528960
110CSNK1D0.16433359
111PRKD20.16251915
112BMX0.14584482
113PRKACB0.14290331
114LATS10.14082246
115TRPM70.14052613
116PIM10.13383725
117CAMK2B0.12767797
118TGFBR20.12634374
119PRKAA10.12429637
120PDGFRB0.12321485
121CSNK1G20.11520601
122SRC0.11473992
123NTRK20.10675452
124CSK0.10559499
125PAK10.10303902
126HIPK20.10073357
127MAPK80.08532356
128AKT10.08245665
129ERBB20.07461760
130PRKD10.06866424
131ERBB30.06750921

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.16727054
2Dilated cardiomyopathy_Homo sapiens_hsa054145.09065253
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.70248909
4Cardiac muscle contraction_Homo sapiens_hsa042603.37039471
5Protein digestion and absorption_Homo sapiens_hsa049743.33081832
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.36363198
7Focal adhesion_Homo sapiens_hsa045102.25884066
8Proteoglycans in cancer_Homo sapiens_hsa052052.12310139
9* Tight junction_Homo sapiens_hsa045302.01795051
10Oxytocin signaling pathway_Homo sapiens_hsa049211.96624938
11Viral myocarditis_Homo sapiens_hsa054161.94843719
12Phototransduction_Homo sapiens_hsa047441.81256375
13Bladder cancer_Homo sapiens_hsa052191.80099915
14Renin-angiotensin system_Homo sapiens_hsa046141.69911802
15Chronic myeloid leukemia_Homo sapiens_hsa052201.64731553
16ECM-receptor interaction_Homo sapiens_hsa045121.43185667
17Insulin signaling pathway_Homo sapiens_hsa049101.41213973
18Glioma_Homo sapiens_hsa052141.39161390
19Adherens junction_Homo sapiens_hsa045201.24405965
20Glucagon signaling pathway_Homo sapiens_hsa049221.21594381
21Amoebiasis_Homo sapiens_hsa051461.20281588
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17205075
23Prion diseases_Homo sapiens_hsa050201.15748782
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.14837983
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13296776
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08100202
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07822500
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.07032750
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05631393
30MAPK signaling pathway_Homo sapiens_hsa040101.04078331
31Hippo signaling pathway_Homo sapiens_hsa043901.03769183
32Melanoma_Homo sapiens_hsa052181.01768766
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00649444
34Amphetamine addiction_Homo sapiens_hsa050310.96844726
35Melanogenesis_Homo sapiens_hsa049160.95706947
36Renal cell carcinoma_Homo sapiens_hsa052110.94886892
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94386901
38Hedgehog signaling pathway_Homo sapiens_hsa043400.92877195
39Small cell lung cancer_Homo sapiens_hsa052220.91298591
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.91014008
41ErbB signaling pathway_Homo sapiens_hsa040120.90838083
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89758604
43mTOR signaling pathway_Homo sapiens_hsa041500.87878524
44Basal cell carcinoma_Homo sapiens_hsa052170.87183335
45HIF-1 signaling pathway_Homo sapiens_hsa040660.87153631
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86947073
47Axon guidance_Homo sapiens_hsa043600.85977879
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84710695
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84464064
50FoxO signaling pathway_Homo sapiens_hsa040680.83053865
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81691961
52Insulin secretion_Homo sapiens_hsa049110.79834826
53cAMP signaling pathway_Homo sapiens_hsa040240.79816266
54Insulin resistance_Homo sapiens_hsa049310.79118046
55Cholinergic synapse_Homo sapiens_hsa047250.76397791
56Gap junction_Homo sapiens_hsa045400.76320642
57Starch and sucrose metabolism_Homo sapiens_hsa005000.73930915
58Circadian rhythm_Homo sapiens_hsa047100.73651245
59Salmonella infection_Homo sapiens_hsa051320.73561594
60VEGF signaling pathway_Homo sapiens_hsa043700.73046697
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.71742632
62Biosynthesis of amino acids_Homo sapiens_hsa012300.71452673
63GnRH signaling pathway_Homo sapiens_hsa049120.71400001
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71113961
65Prostate cancer_Homo sapiens_hsa052150.70719688
66Renin secretion_Homo sapiens_hsa049240.70419941
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70177756
68AMPK signaling pathway_Homo sapiens_hsa041520.69227509
69Bile secretion_Homo sapiens_hsa049760.68598171
70Non-small cell lung cancer_Homo sapiens_hsa052230.67842271
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67605621
72Platelet activation_Homo sapiens_hsa046110.65699506
73Notch signaling pathway_Homo sapiens_hsa043300.64945841
74Pancreatic cancer_Homo sapiens_hsa052120.64926327
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64599145
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63923438
77Gastric acid secretion_Homo sapiens_hsa049710.61766926
78Calcium signaling pathway_Homo sapiens_hsa040200.60671982
79Wnt signaling pathway_Homo sapiens_hsa043100.59931190
80B cell receptor signaling pathway_Homo sapiens_hsa046620.58780595
81Mineral absorption_Homo sapiens_hsa049780.58186689
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57058800
83Nitrogen metabolism_Homo sapiens_hsa009100.57027826
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56669451
85Pertussis_Homo sapiens_hsa051330.56543666
86Salivary secretion_Homo sapiens_hsa049700.56104627
87Ras signaling pathway_Homo sapiens_hsa040140.55434970
88Ovarian steroidogenesis_Homo sapiens_hsa049130.55258487
89Long-term depression_Homo sapiens_hsa047300.55196558
90Pancreatic secretion_Homo sapiens_hsa049720.55115146
91Dorso-ventral axis formation_Homo sapiens_hsa043200.55034204
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54574900
93Estrogen signaling pathway_Homo sapiens_hsa049150.53697765
94Malaria_Homo sapiens_hsa051440.52616505
95Circadian entrainment_Homo sapiens_hsa047130.51857924
96Endocytosis_Homo sapiens_hsa041440.50856752
97Rap1 signaling pathway_Homo sapiens_hsa040150.50742009
98Endometrial cancer_Homo sapiens_hsa052130.50508426
99Carbon metabolism_Homo sapiens_hsa012000.49597035
100TGF-beta signaling pathway_Homo sapiens_hsa043500.49501765
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.48180195
102MicroRNAs in cancer_Homo sapiens_hsa052060.48050191
103Arginine biosynthesis_Homo sapiens_hsa002200.48020102
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46537181
105Long-term potentiation_Homo sapiens_hsa047200.46067566
106Dopaminergic synapse_Homo sapiens_hsa047280.44728189
107Olfactory transduction_Homo sapiens_hsa047400.43634199
108Acute myeloid leukemia_Homo sapiens_hsa052210.43290219
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43254439
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40226815
111Cocaine addiction_Homo sapiens_hsa050300.39922269
112Thyroid hormone synthesis_Homo sapiens_hsa049180.39804092
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37585820
114HTLV-I infection_Homo sapiens_hsa051660.37488483
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37132716
116Pathways in cancer_Homo sapiens_hsa052000.36836209
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35434301
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35265255
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34607162
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34512805
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33026874
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32853985
123Oocyte meiosis_Homo sapiens_hsa041140.31954573
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.31109282
125Thyroid cancer_Homo sapiens_hsa052160.28693819
126Colorectal cancer_Homo sapiens_hsa052100.27963470

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