MYH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* actin-mediated cell contraction (GO:0070252)9.50174448
2skeletal muscle fiber development (GO:0048741)8.58442383
3glycogen catabolic process (GO:0005980)7.46548810
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.30815001
5myotube cell development (GO:0014904)7.30680525
6* actin filament-based movement (GO:0030048)7.06343247
7glucan catabolic process (GO:0009251)6.99615262
8creatine metabolic process (GO:0006600)6.87554617
9skeletal muscle tissue regeneration (GO:0043403)6.74176564
10purine nucleotide salvage (GO:0032261)6.71543577
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.62606954
12striated muscle contraction (GO:0006941)6.55769110
13cellular polysaccharide catabolic process (GO:0044247)6.52006758
14striated muscle atrophy (GO:0014891)6.44096320
15sarcomere organization (GO:0045214)6.43470430
16polysaccharide catabolic process (GO:0000272)6.27677674
17carnitine shuttle (GO:0006853)6.13295260
18negative regulation of fatty acid biosynthetic process (GO:0045717)6.08924722
19response to muscle activity (GO:0014850)6.00880352
20plasma membrane repair (GO:0001778)5.93708347
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.85951839
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.73522450
23regulation of muscle hypertrophy (GO:0014743)5.72501026
24response to inactivity (GO:0014854)5.68914163
25IMP metabolic process (GO:0046040)5.65241918
26regulation of cell communication by electrical coupling (GO:0010649)5.61934533
27pyrimidine ribonucleoside catabolic process (GO:0046133)5.61929613
28myofibril assembly (GO:0030239)5.59931640
29muscle atrophy (GO:0014889)5.58587597
30striated muscle adaptation (GO:0014888)5.50108148
31glycogen biosynthetic process (GO:0005978)5.36423974
32glucan biosynthetic process (GO:0009250)5.36423974
33positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.34174864
34cytidine metabolic process (GO:0046087)5.29211050
35cytidine catabolic process (GO:0006216)5.29211050
36cytidine deamination (GO:0009972)5.29211050
37* muscle contraction (GO:0006936)5.25769294
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.25316534
39fatty acid transmembrane transport (GO:1902001)5.16784025
40muscle fiber development (GO:0048747)4.99889473
41glycogen metabolic process (GO:0005977)4.81493313
42glucan metabolic process (GO:0044042)4.71978763
43cellular glucan metabolic process (GO:0006073)4.71978763
44* muscle system process (GO:0003012)4.71559463
45protein trimerization (GO:0070206)4.69428887
46tissue regeneration (GO:0042246)4.69128442
47neuronal action potential propagation (GO:0019227)4.55831868
48carnitine transmembrane transport (GO:1902603)4.55190625
49actomyosin structure organization (GO:0031032)4.49543696
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.48791713
51muscle adaptation (GO:0043500)4.45126682
52IMP biosynthetic process (GO:0006188)4.44585915
53negative regulation of muscle hypertrophy (GO:0014741)4.38092328
54negative regulation of skeletal muscle tissue development (GO:0048642)4.35773841
55dosage compensation (GO:0007549)4.32303082
56cellular response to glucocorticoid stimulus (GO:0071385)4.30420431
57protein K6-linked ubiquitination (GO:0085020)4.27975098
58response to electrical stimulus (GO:0051602)4.21327367
59cellular carbohydrate catabolic process (GO:0044275)4.21165833
60carnitine transport (GO:0015879)4.16304966
61amino-acid betaine transport (GO:0015838)4.16304966
62negative regulation of organelle assembly (GO:1902116)4.14058898
63negative regulation of striated muscle tissue development (GO:0045843)4.12536194
64cellular response to ketone (GO:1901655)4.10187066
65regulation of acyl-CoA biosynthetic process (GO:0050812)4.09149838
66cellular response to corticosteroid stimulus (GO:0071384)4.05976155
67neuromuscular synaptic transmission (GO:0007274)4.00951481
68cellular response to dexamethasone stimulus (GO:0071549)3.99264610
69negative regulation of muscle tissue development (GO:1901862)3.97457696
70response to testosterone (GO:0033574)3.90593680
71regulation of skeletal muscle cell differentiation (GO:2001014)3.89146543
72positive regulation of histone H3-K4 methylation (GO:0051571)3.88014544
73negative regulation of muscle organ development (GO:0048635)3.87505676
74negative regulation of fatty acid metabolic process (GO:0045922)3.85184435
75cardiac muscle contraction (GO:0060048)3.75039649
76response to dexamethasone (GO:0071548)3.73126458
77heparin metabolic process (GO:0030202)3.71729930
78heparin biosynthetic process (GO:0030210)3.71729930
79muscle organ development (GO:0007517)3.71704070
80regulation of cofactor metabolic process (GO:0051193)3.69168108
81regulation of coenzyme metabolic process (GO:0051196)3.69168108
82muscle structure development (GO:0061061)3.66706503
83regulation of DNA methylation (GO:0044030)3.64004292
84striated muscle cell development (GO:0055002)3.63253967
85myotube differentiation (GO:0014902)3.59808659
86muscle cell cellular homeostasis (GO:0046716)3.58340685
87regulation of centriole replication (GO:0046599)3.55379801
88regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50913966
89negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.48518970
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.47765624
91negative regulation of histone acetylation (GO:0035067)3.45552150
92negative regulation of peptidyl-lysine acetylation (GO:2000757)3.45473712
93skeletal muscle tissue development (GO:0007519)3.43736549
94cellular polysaccharide metabolic process (GO:0044264)3.38494824
95regulation of calcium ion transmembrane transporter activity (GO:1901019)3.36232827
96regulation of calcium ion transmembrane transport (GO:1903169)3.36232827
97regulation of relaxation of muscle (GO:1901077)3.30576746
98regulation of striated muscle contraction (GO:0006942)3.30405978
99regulation of histone H3-K9 methylation (GO:0051570)3.29684064
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25257127
101regulation of actin filament-based movement (GO:1903115)3.24803767
102myoblast fusion (GO:0007520)3.24537787
103neuromuscular junction development (GO:0007528)3.23776084
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.23759907
105endoplasmic reticulum organization (GO:0007029)3.21776108
106tricarboxylic acid cycle (GO:0006099)3.20785291
107cellular polysaccharide biosynthetic process (GO:0033692)3.18391980
108* response to activity (GO:0014823)3.16973433
109negative regulation of histone methylation (GO:0031061)3.14856575
110regulation of gene expression by genetic imprinting (GO:0006349)3.14195662
111polysaccharide biosynthetic process (GO:0000271)3.13817626
112polysaccharide metabolic process (GO:0005976)3.13350115
113mitochondrial calcium ion homeostasis (GO:0051560)3.12009737
114positive regulation of myotube differentiation (GO:0010831)3.10997791
115nucleotide salvage (GO:0043173)3.09930163
116muscle cell development (GO:0055001)3.08962623
117heart process (GO:0003015)3.06877407
118heart contraction (GO:0060047)3.06877407
119intracellular lipid transport (GO:0032365)3.05328148
120positive regulation of myoblast differentiation (GO:0045663)3.05217603
121viral genome replication (GO:0019079)2.91261143
122dicarboxylic acid biosynthetic process (GO:0043650)2.88946797
123complement activation, alternative pathway (GO:0006957)2.83985956
124regulation of muscle system process (GO:0090257)2.83030388
125regulation of skeletal muscle tissue development (GO:0048641)2.78962592
126negative regulation of protein acetylation (GO:1901984)2.74447956
127DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.70816090
128regulation of sarcomere organization (GO:0060297)2.70695932
129regulation of fatty acid biosynthetic process (GO:0042304)2.63972281
130negative regulation of muscle contraction (GO:0045932)2.54965987
131syncytium formation by plasma membrane fusion (GO:0000768)2.47612300
132cellular response to alcohol (GO:0097306)2.42682811
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41723359
134cellular glucuronidation (GO:0052695)2.41423388
135regulation of female gonad development (GO:2000194)2.40206835
136uronic acid metabolic process (GO:0006063)2.39767093
137glucuronate metabolic process (GO:0019585)2.39767093
138relaxation of muscle (GO:0090075)2.39395950
139monocyte differentiation (GO:0030224)2.37214888
140regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36153867
141protein localization to microtubule (GO:0035372)2.36111282
142cellular ketone body metabolic process (GO:0046950)2.35188727
143anterior/posterior axis specification, embryo (GO:0008595)2.34631701
144DNA damage response, signal transduction resulting in transcription (GO:0042772)2.34374141
145calcium ion import (GO:0070509)2.34299753
146positive regulation vascular endothelial growth factor production (GO:0010575)2.34294077
147regulation of muscle adaptation (GO:0043502)2.31257746
148genetic imprinting (GO:0071514)2.30481584
149response to gravity (GO:0009629)15.0664109
150regulation of skeletal muscle contraction (GO:0014819)13.2437043
151* actin-myosin filament sliding (GO:0033275)11.6891827
152* muscle filament sliding (GO:0030049)11.6891827
153skeletal muscle contraction (GO:0003009)11.1147884
154skeletal muscle adaptation (GO:0043501)10.9339038
155sarcoplasmic reticulum calcium ion transport (GO:0070296)10.3286348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.14378548
2VDR_22108803_ChIP-Seq_LS180_Human7.98382925
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.50453907
4TAF15_26573619_Chip-Seq_HEK293_Human4.47708948
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47077555
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.59816560
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28191780
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.16378946
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05518065
10ZNF263_19887448_ChIP-Seq_K562_Human2.54862272
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.48663651
12AR_21572438_ChIP-Seq_LNCaP_Human2.46416155
13FUS_26573619_Chip-Seq_HEK293_Human2.45197121
14BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.41809786
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39097588
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25977042
17TBX20_22328084_ChIP-Seq_HEART_Mouse2.16339452
18TBX20_22080862_ChIP-Seq_HEART_Mouse2.16339452
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12630546
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09055685
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06192503
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.92592853
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.90437624
24GBX2_23144817_ChIP-Seq_PC3_Human1.87314951
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87232506
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80886316
27CTCF_21964334_ChIP-Seq_BJAB-B_Human1.80080679
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.78291082
29GATA1_22025678_ChIP-Seq_K562_Human1.77089465
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.75608421
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75240653
32ER_23166858_ChIP-Seq_MCF-7_Human1.73565291
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73371339
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.72767761
35CTCF_27219007_Chip-Seq_Bcells_Human1.72286807
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.71489323
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66484443
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64690045
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63598440
40RXR_22108803_ChIP-Seq_LS180_Human1.60753884
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.59466349
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58149990
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.57367527
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.57274754
45CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56391076
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.51932222
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.49220152
48PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.48786292
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47371100
50EZH2_22144423_ChIP-Seq_EOC_Human1.45562973
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44847669
52SMAD4_21799915_ChIP-Seq_A2780_Human1.44340750
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44195956
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43198951
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.41022161
56ZNF274_21170338_ChIP-Seq_K562_Hela1.40347777
57STAT1_20625510_ChIP-Seq_HELA_Human1.39424540
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38087212
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37662811
60CLOCK_20551151_ChIP-Seq_293T_Human1.37514407
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37215985
62SA1_27219007_Chip-Seq_Bcells_Human1.36115959
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34894909
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.33830923
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32339217
66FOXH1_21741376_ChIP-Seq_ESCs_Human1.31786695
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31755968
68KDM2B_26808549_Chip-Seq_DND41_Human1.30158534
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.29627081
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28821584
71MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.26980342
72* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22996074
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22634983
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21444195
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.20625275
76DROSHA_22980978_ChIP-Seq_HELA_Human1.19433236
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.19162554
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17898074
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16248662
80OCT4_20526341_ChIP-Seq_ESCs_Human1.16013935
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14594047
82CREB1_26743006_Chip-Seq_LNCaP_Human1.14494965
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14118411
84CTCF_21964334_Chip-Seq_Bcells_Human1.13638630
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13318049
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12415580
87* KDM2B_26808549_Chip-Seq_REH_Human1.12322823
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12032403
89SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12015445
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.11557271
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.11095882
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.10464323
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10337440
94VDR_24787735_ChIP-Seq_THP-1_Human1.10162132
95* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10113083
96LXR_22292898_ChIP-Seq_THP-1_Human1.10062934
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09887854
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09887854
99STAT3_23295773_ChIP-Seq_U87_Human1.09784507
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.09688044
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08554675
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08337030
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07546712
104* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07217672
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06478970
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.06259294
107RACK7_27058665_Chip-Seq_MCF-7_Human1.06030899
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05908283
109CBP_20019798_ChIP-Seq_JUKART_Human1.05432441
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05432441
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.04330498
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04158280
113TCF4_23295773_ChIP-Seq_U87_Human1.03807161
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03521620
115MYC_27129775_Chip-Seq_CORNEA_Mouse1.03376751
116NANOG_20526341_ChIP-Seq_ESCs_Human1.02841165
117RAC3_21632823_ChIP-Seq_H3396_Human1.02601605
118TP53_20018659_ChIP-ChIP_R1E_Mouse1.02544622
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02530105
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02424209
121P68_20966046_ChIP-Seq_HELA_Human1.01356618
122SPI1_23127762_ChIP-Seq_K562_Human1.00120193
123TCF7_22412390_ChIP-Seq_EML_Mouse1.00103034
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.99298071
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98924042
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98627201
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97537187
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97051458
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95886671
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95856682
131E2F1_20622854_ChIP-Seq_HELA_Human0.95740827
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95551114
133GATA6_21074721_ChIP-Seq_CACO-2_Human0.94699407
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94580934
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94580934
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94443199
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94220102
138LXR_22158963_ChIP-Seq_LIVER_Mouse0.92399125
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91955464
140SOX9_26525672_Chip-Seq_HEART_Mouse0.91941139
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91859789
142ATF3_27146783_Chip-Seq_COLON_Human0.91714782
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.91252657
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91069990
145TP63_22573176_ChIP-Seq_HFKS_Human0.90969152
146GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89250862
147HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89076990
148FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88995513
149BCL6_27268052_Chip-Seq_Bcells_Human0.88808190
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88619394
151* CEBPB_22108803_ChIP-Seq_LS180_Human0.87879247
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87845750
153OCT1_27270436_Chip-Seq_PROSTATE_Human0.87624150
154SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87594127
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.87517891
156SPI1_20517297_ChIP-Seq_HL60_Human0.87144398
157FLI1_21867929_ChIP-Seq_TH2_Mouse0.86840389
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86787623
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86717855
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.86358818
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85946427
162* CTCF_26484167_Chip-Seq_Bcells_Mouse0.85489628
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85113544
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84791277
165AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84595690
166SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84473129
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.84144177
168SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83898674
169STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83602251
170E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82898986
171TP53_18474530_ChIP-ChIP_U2OS_Human0.82861501
172P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82849971
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82585735
174CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81796780
175AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81749133
176SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81653336
177NANOG_18555785_Chip-Seq_ESCs_Mouse0.81580630
178SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80821236
179P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80149136
180DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79498922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.42097317
2MP0003646_muscle_fatigue6.50251892
3MP0000749_muscle_degeneration6.45723842
4MP0000751_myopathy5.54235055
5MP0002106_abnormal_muscle_physiology4.35472342
6MP0004036_abnormal_muscle_relaxation4.20765538
7* MP0000747_muscle_weakness3.91037987
8* MP0000759_abnormal_skeletal_muscle3.78857029
9MP0005369_muscle_phenotype3.63727189
10MP0004130_abnormal_muscle_cell3.47274357
11MP0002837_dystrophic_cardiac_calcinosis3.27314374
12* MP0004087_abnormal_muscle_fiber3.23465968
13* MP0002269_muscular_atrophy3.23042231
14MP0000750_abnormal_muscle_regeneration3.13446635
15* MP0005620_abnormal_muscle_contractility3.04567694
16MP0004233_abnormal_muscle_weight2.62441636
17MP0000733_abnormal_muscle_development2.35111506
18MP0002332_abnormal_exercise_endurance2.23777436
19MP0000566_synostosis2.18414517
20MP0002108_abnormal_muscle_morphology2.16006973
21MP0001661_extended_life_span1.87881414
22MP0006036_abnormal_mitochondrial_physio1.87039119
23MP0004185_abnormal_adipocyte_glucose1.86931541
24MP0002139_abnormal_hepatobiliary_system1.74020946
25MP0009780_abnormal_chondrocyte_physiolo1.72481841
26MP0005330_cardiomyopathy1.64768523
27MP0005275_abnormal_skin_tensile1.63317855
28MP0002638_abnormal_pupillary_reflex1.59646953
29MP0002971_abnormal_brown_adipose1.43625202
30MP0004270_analgesia1.41062970
31MP0005666_abnormal_adipose_tissue1.40472546
32MP0004084_abnormal_cardiac_muscle1.34037839
33MP0003806_abnormal_nucleotide_metabolis1.28869457
34MP0003705_abnormal_hypodermis_morpholog1.26682205
35MP0000467_abnormal_esophagus_morphology1.19868021
36MP0005085_abnormal_gallbladder_physiolo1.16603091
37MP0002972_abnormal_cardiac_muscle1.11742738
38MP0002138_abnormal_hepatobiliary_system1.09895734
39MP0003221_abnormal_cardiomyocyte_apopto1.07497038
40MP0010630_abnormal_cardiac_muscle1.05599003
41MP0008057_abnormal_DNA_replication1.05114027
42MP0005375_adipose_tissue_phenotype1.03808048
43MP0005266_abnormal_metabolism1.02159506
44MP0006035_abnormal_mitochondrial_morpho1.01577929
45MP0004215_abnormal_myocardial_fiber1.01483284
46MP0004134_abnormal_chest_morphology1.00353161
47MP0004484_altered_response_of0.99634757
48MP0010307_abnormal_tumor_latency0.98742084
49MP0002796_impaired_skin_barrier0.93553041
50MP0002736_abnormal_nociception_after0.93507673
51MP0003937_abnormal_limbs/digits/tail_de0.92392306
52MP0000013_abnormal_adipose_tissue0.91769822
53MP0003656_abnormal_erythrocyte_physiolo0.87076929
54MP0005167_abnormal_blood-brain_barrier0.80349834
55MP0003385_abnormal_body_wall0.79401602
56MP0001968_abnormal_touch/_nociception0.78824729
57MP0004147_increased_porphyrin_level0.77177527
58MP0000372_irregular_coat_pigmentation0.76853764
59MP0009250_abnormal_appendicular_skeleto0.75802345
60MP0000762_abnormal_tongue_morphology0.75492840
61MP0002115_abnormal_skeleton_extremities0.75355733
62MP0001544_abnormal_cardiovascular_syste0.73944633
63MP0005385_cardiovascular_system_phenoty0.73944633
64MP0008961_abnormal_basal_metabolism0.70864739
65MP0002234_abnormal_pharynx_morphology0.69761349
66MP0001299_abnormal_eye_distance/0.69206305
67MP0005334_abnormal_fat_pad0.69011041
68MP0005365_abnormal_bile_salt0.68836298
69MP0003950_abnormal_plasma_membrane0.67853281
70MP0004043_abnormal_pH_regulation0.65939558
71MP0003566_abnormal_cell_adhesion0.65576125
72MP0003191_abnormal_cellular_cholesterol0.63849517
73MP0002078_abnormal_glucose_homeostasis0.63722922
74MP0003868_abnormal_feces_composition0.63493711
75MP0003252_abnormal_bile_duct0.62360232
76MP0005670_abnormal_white_adipose0.61064207
77MP0001879_abnormal_lymphatic_vessel0.60785741
78MP0003137_abnormal_impulse_conducting0.60248601
79MP0002089_abnormal_postnatal_growth/wei0.58690122
80MP0002095_abnormal_skin_pigmentation0.57813672
81MP0005083_abnormal_biliary_tract0.57692063
82MP0000579_abnormal_nail_morphology0.56681550
83MP0005503_abnormal_tendon_morphology0.54381067
84MP0000003_abnormal_adipose_tissue0.52784554
85MP0005248_abnormal_Harderian_gland0.52547114
86MP0003959_abnormal_lean_body0.51159262
87MP0005584_abnormal_enzyme/coenzyme_acti0.49235566
88MP0005452_abnormal_adipose_tissue0.49125328
89MP0009672_abnormal_birth_weight0.49064714
90MP0002896_abnormal_bone_mineralization0.47283454
91MP0000470_abnormal_stomach_morphology0.47266796
92MP0008569_lethality_at_weaning0.47016712
93MP0003755_abnormal_palate_morphology0.46884911
94MP0000343_altered_response_to0.46867384
95MP0000266_abnormal_heart_morphology0.46428181
96MP0003880_abnormal_central_pattern0.46411101
97MP0005423_abnormal_somatic_nervous0.45773006
98MP0001243_abnormal_dermal_layer0.45437825
99MP0000383_abnormal_hair_follicle0.45179812
100MP0003795_abnormal_bone_structure0.42362054
101MP0005501_abnormal_skin_physiology0.41926968
102MP0005023_abnormal_wound_healing0.40918617
103MP0003045_fibrosis0.40885570
104MP0004142_abnormal_muscle_tone0.40668824
105MP0002127_abnormal_cardiovascular_syste0.40115461
106MP0002249_abnormal_larynx_morphology0.40055402
107MP0010234_abnormal_vibrissa_follicle0.39382005
108MP0003091_abnormal_cell_migration0.39071567
109MP0002168_other_aberrant_phenotype0.39049588
110MP0001849_ear_inflammation0.37676513
111MP0003879_abnormal_hair_cell0.36182661
112MP0008775_abnormal_heart_ventricle0.36051870
113MP0002734_abnormal_mechanical_nocicepti0.35861793
114MP0009697_abnormal_copulation0.35795056
115MP0009703_decreased_birth_body0.34781074
116MP0009115_abnormal_fat_cell0.33062336
117MP0002114_abnormal_axial_skeleton0.33027602
118MP0003948_abnormal_gas_homeostasis0.31305915
119MP0000427_abnormal_hair_cycle0.31204134
120MP0002060_abnormal_skin_morphology0.30925319
121MP0005319_abnormal_enzyme/_coenzyme0.30699479
122MP0002118_abnormal_lipid_homeostasis0.27609068
123MP0010678_abnormal_skin_adnexa0.27347588
124MP0003195_calcinosis0.27077795
125MP0008438_abnormal_cutaneous_collagen0.26926462
126MP0002822_catalepsy0.25923791
127MP0005535_abnormal_body_temperature0.25177713
128MP0000377_abnormal_hair_follicle0.24713174
129MP0000230_abnormal_systemic_arterial0.24156615
130MP0005451_abnormal_body_composition0.24035613
131MP0009931_abnormal_skin_appearance0.23886855
132MP0008770_decreased_survivor_rate0.23001817
133MP0005376_homeostasis/metabolism_phenot0.22660006
134MP0001943_abnormal_respiration0.22637882
135MP0006138_congestive_heart_failure0.22243707
136MP0005076_abnormal_cell_differentiation0.19576527
137MP0002932_abnormal_joint_morphology0.19338834
138MP0002109_abnormal_limb_morphology0.17928089

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.30205629
2Exercise-induced myalgia (HP:0003738)9.18900362
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.10600652
4Palpebral edema (HP:0100540)8.85954756
5Exercise-induced muscle cramps (HP:0003710)8.52590331
6Nemaline bodies (HP:0003798)8.51539015
7Distal arthrogryposis (HP:0005684)7.25960684
8Mask-like facies (HP:0000298)7.16920631
9Type 1 muscle fiber predominance (HP:0003803)6.96944368
10Myopathic facies (HP:0002058)6.94228513
11Muscle hypertrophy of the lower extremities (HP:0008968)6.85882504
12Round ear (HP:0100830)6.61120794
13Ulnar deviation of the wrist (HP:0003049)6.52470297
14Calf muscle hypertrophy (HP:0008981)5.92385535
15Calcaneovalgus deformity (HP:0001848)5.64915803
16Difficulty running (HP:0009046)5.62819571
17Myoglobinuria (HP:0002913)5.57498137
18Deformed tarsal bones (HP:0008119)5.33616107
19Absent phalangeal crease (HP:0006109)5.26328540
20Muscle fiber splitting (HP:0003555)5.11771648
21Muscle stiffness (HP:0003552)4.95131031
22Rhabdomyolysis (HP:0003201)4.71390602
23Hyporeflexia of lower limbs (HP:0002600)4.69442136
24Increased connective tissue (HP:0009025)4.56073360
25Abnormal finger flexion creases (HP:0006143)4.40881857
26EMG: myopathic abnormalities (HP:0003458)4.39644221
27Myotonia (HP:0002486)4.26761543
28Periorbital edema (HP:0100539)4.13172954
29Facial edema (HP:0000282)3.97249009
30Abnormality of the calf musculature (HP:0001430)3.84804651
31Abnormality of skeletal muscle fiber size (HP:0012084)3.84583674
32Malignant hyperthermia (HP:0002047)3.74712741
33Abnormality of the left ventricular outflow tract (HP:0011103)3.60628858
34Subaortic stenosis (HP:0001682)3.60628858
35Increased variability in muscle fiber diameter (HP:0003557)3.42996517
36Abnormality of the calcaneus (HP:0008364)3.42162676
37Difficulty climbing stairs (HP:0003551)3.33589786
38Rimmed vacuoles (HP:0003805)3.31914371
39Shoulder girdle muscle weakness (HP:0003547)3.28679656
40Pelvic girdle muscle weakness (HP:0003749)3.28322902
41Hyperkalemia (HP:0002153)3.27077159
42Neck muscle weakness (HP:0000467)3.26627577
43Abnormality of the hip-girdle musculature (HP:0001445)3.17611712
44Abnormality of the musculature of the pelvis (HP:0001469)3.17611712
45Frequent falls (HP:0002359)3.15801550
46Neoplasm of the heart (HP:0100544)3.07940758
47Areflexia of lower limbs (HP:0002522)3.05089480
48Paralysis (HP:0003470)2.88275523
49Asymmetric septal hypertrophy (HP:0001670)2.77446973
50Slender build (HP:0001533)2.67194932
51Microglossia (HP:0000171)2.66918415
52Abnormality of the neuromuscular junction (HP:0003398)2.61187741
53Fatigable weakness (HP:0003473)2.61187741
54Bell-shaped thorax (HP:0001591)2.50196115
55Sudden death (HP:0001699)2.44572266
56EMG: neuropathic changes (HP:0003445)2.41726918
57Distal lower limb muscle weakness (HP:0009053)2.40325058
58Hypoalphalipoproteinemia (HP:0003233)2.39036823
59Muscular dystrophy (HP:0003560)2.37935700
60Hypoplastic ischia (HP:0003175)2.25458146
61Limb-girdle muscle weakness (HP:0003325)2.25296282
62Nonprogressive disorder (HP:0003680)2.23818894
63Down-sloping shoulders (HP:0200021)2.20227837
64Reduced subcutaneous adipose tissue (HP:0003758)2.16839148
65Mildly elevated creatine phosphokinase (HP:0008180)2.15350911
66Ulnar deviation of finger (HP:0009465)2.14752900
67Metatarsus adductus (HP:0001840)2.14367678
68Hyperphosphatemia (HP:0002905)2.11180225
69Decreased circulating renin level (HP:0003351)2.10691011
70Generalized muscle weakness (HP:0003324)2.10474429
71Proximal amyotrophy (HP:0007126)2.09988798
72Bulbar palsy (HP:0001283)2.05710262
73Spinal rigidity (HP:0003306)2.04442892
74Abnormality of the peritoneum (HP:0002585)1.99688482
75Abnormality of the shoulder girdle musculature (HP:0001435)1.97288042
76Abnormality of the ischium (HP:0003174)1.97021804
77Centrally nucleated skeletal muscle fibers (HP:0003687)1.96151195
78Limb-girdle muscle atrophy (HP:0003797)1.93951441
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93452123
80Rectal prolapse (HP:0002035)1.90040353
81Scapular winging (HP:0003691)1.88532235
82Achilles tendon contracture (HP:0001771)1.87872426
83Facial diplegia (HP:0001349)1.86001546
84Tarsal synostosis (HP:0008368)1.85773178
85Distal lower limb amyotrophy (HP:0008944)1.84309401
86Lip pit (HP:0100267)1.83221994
87Stridor (HP:0010307)1.82266035
88Gowers sign (HP:0003391)1.79700498
89Weak cry (HP:0001612)1.76176158
90Hyperuricemia (HP:0002149)1.75108252
91Increased purine levels (HP:0004368)1.75108252
92Hypolipoproteinemia (HP:0010981)1.74048188
93Ventricular tachycardia (HP:0004756)1.71563630
94Abnormality of the Achilles tendon (HP:0005109)1.71494330
95Gout (HP:0001997)1.71370192
96Waddling gait (HP:0002515)1.70737311
97Increased density of long bones (HP:0006392)1.70228206
98Abnormality of potassium homeostasis (HP:0011042)1.69416686
99Cholelithiasis (HP:0001081)1.69136065
100Short palpebral fissure (HP:0012745)1.68625119
101Spontaneous abortion (HP:0005268)1.68470208
102Complement deficiency (HP:0004431)1.68089020
103Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.67232819
104Synostosis involving bones of the feet (HP:0009140)1.67174782
105Synostosis involving bones of the lower limbs (HP:0009138)1.67174782
106Abnormality of chloride homeostasis (HP:0011422)1.66868771
107Glomerulonephritis (HP:0000099)1.64928562
108Progressive muscle weakness (HP:0003323)1.61996121
109Oligomenorrhea (HP:0000876)1.59735689
110Hypoplastic iliac wings (HP:0002866)1.55592034
111Mesomelia (HP:0003027)1.54779106
112Fetal akinesia sequence (HP:0001989)1.54160676
113Supernumerary ribs (HP:0005815)1.51604798
114Atrioventricular block (HP:0001678)1.51312568
115Fibular aplasia (HP:0002990)1.49909944
116Abnormal gallbladder morphology (HP:0012437)1.49759496
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.49677700
118Adducted thumb (HP:0001181)1.49634491
119Menstrual irregularities (HP:0000858)1.49459061
120Abnormality of the columella (HP:0009929)1.48638214
121Congenital hip dislocation (HP:0001374)1.46498884
122Hypokalemia (HP:0002900)1.44856718
123Long clavicles (HP:0000890)1.41760471
124Abnormality of purine metabolism (HP:0004352)1.41248670
125Toxemia of pregnancy (HP:0100603)1.41233974
126Intellectual disability, moderate (HP:0002342)1.39974908
127Heart block (HP:0012722)1.39798997
128Macroorchidism (HP:0000053)1.39683471
129Wrist flexion contracture (HP:0001239)1.39222240
130Supernumerary bones of the axial skeleton (HP:0009144)1.38854220
131Exercise intolerance (HP:0003546)1.38085053
132Broad metatarsal (HP:0001783)1.35360363
133Abnormality of the parietal bone (HP:0002696)1.34182355
134Abnormal atrioventricular conduction (HP:0005150)1.32293264
135Decreased subcutaneous fat (HP:0001002)1.31981200
136Insulin-resistant diabetes mellitus (HP:0000831)1.31971756
137Hip contracture (HP:0003273)1.31304236
138Metabolic acidosis (HP:0001942)1.31043983
139Overgrowth (HP:0001548)1.30406841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.94589606
2TTN6.52554614
3PHKG26.43488852
4PHKG16.43488852
5NME14.61888144
6PIK3CG3.52311620
7MAP2K33.03253884
8TYRO32.73270925
9WNK42.58182642
10WNK12.51372847
11NEK12.40387551
12MAP3K72.22844557
13JAK32.18256887
14PINK12.07158882
15IRAK11.95850508
16PIK3CA1.93819353
17CAMKK21.87440984
18PDK31.83344436
19PDK41.83344436
20MAP2K41.83100263
21MAPK131.83072602
22TRIB31.82891784
23CASK1.74694273
24MAPK121.68292009
25BCKDK1.64890517
26MAP2K61.56483968
27DMPK1.55583485
28CDK41.44695281
29PDK21.22504651
30CHEK21.21539977
31CCNB11.10243047
32FGFR31.09975727
33PRKAA21.01695262
34NEK90.94006593
35PRKAA10.91239149
36AURKA0.90111950
37MAPKAPK30.89931235
38MAP3K30.88895140
39MUSK0.86834840
40CAMK40.82477142
41SGK20.82123704
42ERBB30.80840505
43TAOK20.79117115
44MARK30.78213514
45TRPM70.76558523
46MAP3K90.75973334
47STK240.75734351
48SCYL20.74526866
49MARK20.65144747
50SIK10.63625978
51MAPK110.61696747
52PRKD20.61386747
53CAMK10.60780651
54MAP3K110.60592206
55TAOK10.60095968
56MAP3K120.59108879
57CAMK2G0.58970390
58CAMKK10.58680070
59STK390.58330332
60RIPK10.58126114
61PDGFRA0.57624608
62NLK0.56389089
63EPHB10.53650771
64STK380.53293288
65PKN20.51853901
66FGFR20.51436238
67SGK2230.48752129
68SGK4940.48752129
69DAPK20.47050031
70ZAK0.47029498
71AKT20.46805638
72EEF2K0.44266901
73PTK60.43943585
74MAP3K60.40377112
75KSR20.39536285
76ILK0.37550401
77SGK10.35614721
78TEC0.35483485
79MAP3K10.33475266
80NUAK10.32724839
81DYRK30.32358431
82LIMK10.31406986
83CAMK1G0.29476207
84PRKACB0.28460179
85RPS6KA30.27594256
86MAP3K50.27409734
87PRKG10.26730773
88PKN10.26581700
89MAP3K100.25953380
90RPS6KB10.24193141
91ARAF0.23557205
92MAPK70.22303806
93PDGFRB0.21660997
94ERN10.21094095
95MAPK40.20797650
96PRKACA0.19807595
97TYK20.19550441
98EIF2AK20.19084487
99TNIK0.18608040
100RAF10.18430810
101PAK60.17779980
102LATS10.17460497
103MAP2K10.16649069
104MST1R0.16506586
105PDPK10.15328454
106PRKD10.15187637
107CSNK1G10.15080310
108FRK0.14052444
109PRKD30.13913720
110LATS20.13788024
111AKT30.13322850
112PRKG20.12547553
113GSK3B0.12433899
114PDK10.12066945
115DYRK1B0.12008214
116ROCK10.11144313
117TIE10.10932927
118DDR20.10842735
119FER0.10697892
120TGFBR20.10277406
121FGFR10.10116397
122RPS6KA10.10083424
123LRRK20.09313414
124BMX0.09111012
125INSRR0.08978593
126MOS0.06858222
127PRKACG0.06723713
128JAK20.05957586
129STK110.05769262
130GSK3A0.05366930
131ICK0.05077585
132MAPK100.04316379
133KSR10.04196800
134MTOR0.04156439
135SGK30.02836670
136MAPK80.02553786
137CSNK1D0.02376870
138CAMK2D0.01616888
139RPS6KA20.01224541
140PNCK0.01139511
141PTK2B0.00798571
142RET-0.0058570
143CAMK1D-0.0046763
144MAPK9-0.0039063
145RPS6KB2-0.0034246
146MAP3K4-0.0033529

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.11915478
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.90016728
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.77930529
4Starch and sucrose metabolism_Homo sapiens_hsa005003.26680606
5Cardiac muscle contraction_Homo sapiens_hsa042603.25402256
6Dilated cardiomyopathy_Homo sapiens_hsa054143.17507659
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.09322777
8Regulation of autophagy_Homo sapiens_hsa041402.97099909
9Circadian rhythm_Homo sapiens_hsa047102.62932368
10Glucagon signaling pathway_Homo sapiens_hsa049222.58753691
11Insulin signaling pathway_Homo sapiens_hsa049102.45225820
12Oxytocin signaling pathway_Homo sapiens_hsa049212.45033207
13Propanoate metabolism_Homo sapiens_hsa006402.28121845
14Insulin resistance_Homo sapiens_hsa049312.27497145
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.25245627
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19759880
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17332985
18Carbon metabolism_Homo sapiens_hsa012002.14054914
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.95434139
20Galactose metabolism_Homo sapiens_hsa000521.94711962
21Complement and coagulation cascades_Homo sapiens_hsa046101.92994452
22Calcium signaling pathway_Homo sapiens_hsa040201.89562155
23AMPK signaling pathway_Homo sapiens_hsa041521.84215489
24Fructose and mannose metabolism_Homo sapiens_hsa000511.73727154
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70461007
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67311573
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60037973
28Biosynthesis of amino acids_Homo sapiens_hsa012301.55950496
29Alzheimers disease_Homo sapiens_hsa050101.49628744
30Chemical carcinogenesis_Homo sapiens_hsa052041.45105902
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42288406
32Pentose phosphate pathway_Homo sapiens_hsa000301.40814436
33Pyruvate metabolism_Homo sapiens_hsa006201.40362164
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39480738
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38345279
36Parkinsons disease_Homo sapiens_hsa050121.38339377
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37125233
38Arginine and proline metabolism_Homo sapiens_hsa003301.34206843
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30996921
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27517891
41Retinol metabolism_Homo sapiens_hsa008301.22906652
42Bile secretion_Homo sapiens_hsa049761.22034168
43Fatty acid degradation_Homo sapiens_hsa000711.21566378
44Viral myocarditis_Homo sapiens_hsa054161.19755213
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.17597181
46Wnt signaling pathway_Homo sapiens_hsa043101.17016205
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13247845
48Gastric acid secretion_Homo sapiens_hsa049711.13219675
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11915827
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11718247
51Oxidative phosphorylation_Homo sapiens_hsa001901.11162610
52GnRH signaling pathway_Homo sapiens_hsa049121.09686846
53Focal adhesion_Homo sapiens_hsa045101.05409962
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.03216164
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99524697
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98401938
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.97729026
58FoxO signaling pathway_Homo sapiens_hsa040680.97332448
59Fatty acid metabolism_Homo sapiens_hsa012120.91651501
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91203681
61Dopaminergic synapse_Homo sapiens_hsa047280.90409179
62* Tight junction_Homo sapiens_hsa045300.88100886
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.87445194
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86100329
65Arginine biosynthesis_Homo sapiens_hsa002200.85375890
66Hedgehog signaling pathway_Homo sapiens_hsa043400.85102184
67VEGF signaling pathway_Homo sapiens_hsa043700.80157459
68Renin secretion_Homo sapiens_hsa049240.78347604
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76948516
70Fatty acid biosynthesis_Homo sapiens_hsa000610.76536618
71mTOR signaling pathway_Homo sapiens_hsa041500.75765067
72Estrogen signaling pathway_Homo sapiens_hsa049150.71729612
73HIF-1 signaling pathway_Homo sapiens_hsa040660.71457767
74Glioma_Homo sapiens_hsa052140.70618875
75Oocyte meiosis_Homo sapiens_hsa041140.67988589
76Systemic lupus erythematosus_Homo sapiens_hsa053220.67975616
77MAPK signaling pathway_Homo sapiens_hsa040100.67948722
78Amphetamine addiction_Homo sapiens_hsa050310.67884810
79Morphine addiction_Homo sapiens_hsa050320.65769160
80ErbB signaling pathway_Homo sapiens_hsa040120.65127117
81PPAR signaling pathway_Homo sapiens_hsa033200.63003735
82GABAergic synapse_Homo sapiens_hsa047270.62454163
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62453559
84Platelet activation_Homo sapiens_hsa046110.61628648
85Histidine metabolism_Homo sapiens_hsa003400.61524618
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.61129153
87Caffeine metabolism_Homo sapiens_hsa002320.57949626
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57522049
89Olfactory transduction_Homo sapiens_hsa047400.55366929
90cAMP signaling pathway_Homo sapiens_hsa040240.54451520
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.50498178
92Serotonergic synapse_Homo sapiens_hsa047260.50297591
93Type II diabetes mellitus_Homo sapiens_hsa049300.50009694
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48677241
95Insulin secretion_Homo sapiens_hsa049110.48051394
96beta-Alanine metabolism_Homo sapiens_hsa004100.47997936
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47912306
98Basal cell carcinoma_Homo sapiens_hsa052170.46068795
99Amoebiasis_Homo sapiens_hsa051460.45218739
100Adherens junction_Homo sapiens_hsa045200.44684539
101Tryptophan metabolism_Homo sapiens_hsa003800.43582575
102Long-term depression_Homo sapiens_hsa047300.43428735
103Salivary secretion_Homo sapiens_hsa049700.43316518
104Axon guidance_Homo sapiens_hsa043600.43064287
105Huntingtons disease_Homo sapiens_hsa050160.42491536
106Dorso-ventral axis formation_Homo sapiens_hsa043200.42234217
107Nitrogen metabolism_Homo sapiens_hsa009100.39653506
108Melanoma_Homo sapiens_hsa052180.37677684
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37624908
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36039262
111Proteoglycans in cancer_Homo sapiens_hsa052050.35172516
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33175528
113Thyroid hormone synthesis_Homo sapiens_hsa049180.32502296
114Butanoate metabolism_Homo sapiens_hsa006500.31327067
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29377927
116Renal cell carcinoma_Homo sapiens_hsa052110.27872226
117Cholinergic synapse_Homo sapiens_hsa047250.23916467
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21836402
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21412664
120Pancreatic secretion_Homo sapiens_hsa049720.20993274
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20375001
122Fatty acid elongation_Homo sapiens_hsa000620.20086844
123Long-term potentiation_Homo sapiens_hsa047200.19692742
124Sulfur metabolism_Homo sapiens_hsa009200.19584715
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.18646647
126Phenylalanine metabolism_Homo sapiens_hsa003600.17328394
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17248470
128Circadian entrainment_Homo sapiens_hsa047130.15831395
129Linoleic acid metabolism_Homo sapiens_hsa005910.15291760
130Prolactin signaling pathway_Homo sapiens_hsa049170.13600543
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13563592
132Melanogenesis_Homo sapiens_hsa049160.13549564
133Peroxisome_Homo sapiens_hsa041460.11930902
134ABC transporters_Homo sapiens_hsa020100.11307938
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.10656349
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09557614
137Fat digestion and absorption_Homo sapiens_hsa049750.07503943
138ECM-receptor interaction_Homo sapiens_hsa045120.07261020
139Metabolic pathways_Homo sapiens_hsa011000.07230596
140Sulfur relay system_Homo sapiens_hsa041220.07011977
141Thyroid cancer_Homo sapiens_hsa052160.06311022
142Acute myeloid leukemia_Homo sapiens_hsa052210.06136148
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.05691904
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03641022
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03486933

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