MYH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)9.65153495
2cardiac myofibril assembly (GO:0055003)9.42161882
3cardiac chamber formation (GO:0003207)8.43479402
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.78979532
5* myofibril assembly (GO:0030239)7.54807194
6cardiac ventricle formation (GO:0003211)7.49473562
7negative regulation of potassium ion transmembrane transport (GO:1901380)7.29437773
8cardiac muscle contraction (GO:0060048)7.22004107
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.85332276
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.72979356
11atrial septum morphogenesis (GO:0060413)6.68460211
12plasma membrane repair (GO:0001778)6.67963760
13* muscle filament sliding (GO:0030049)6.51514327
14* actin-myosin filament sliding (GO:0033275)6.51514327
15regulation of actin filament-based movement (GO:1903115)6.45349521
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.27887417
17* cardiac muscle cell development (GO:0055013)6.27796771
18ventricular cardiac muscle cell action potential (GO:0086005)6.23760146
19* ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.13953258
20bundle of His cell to Purkinje myocyte communication (GO:0086069)6.09229678
21* cardiac muscle tissue morphogenesis (GO:0055008)6.05849653
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.05809126
23* actomyosin structure organization (GO:0031032)5.97497488
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.91464365
25* cardiac cell development (GO:0055006)5.89599602
26tricarboxylic acid cycle (GO:0006099)5.85859807
27regulation of relaxation of muscle (GO:1901077)5.75854038
28cardiac muscle hypertrophy (GO:0003300)5.68853032
29atrioventricular valve morphogenesis (GO:0003181)5.64077587
30* adult heart development (GO:0007512)5.55616380
31regulation of skeletal muscle contraction (GO:0014819)5.43669653
32striated muscle hypertrophy (GO:0014897)5.36634447
33heart trabecula formation (GO:0060347)5.36532072
34* muscle tissue morphogenesis (GO:0060415)5.35258757
35* actin-mediated cell contraction (GO:0070252)5.34589971
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.23683776
37regulation of striated muscle contraction (GO:0006942)5.20277395
38heart process (GO:0003015)5.19396623
39heart contraction (GO:0060047)5.19396623
40* striated muscle contraction (GO:0006941)5.11661681
41regulation of sarcomere organization (GO:0060297)5.03657112
42cell communication involved in cardiac conduction (GO:0086065)5.03127883
43carnitine shuttle (GO:0006853)4.93137705
44cardiac muscle tissue development (GO:0048738)4.89313359
45negative regulation of myotube differentiation (GO:0010832)4.88864082
46oxygen transport (GO:0015671)4.83308403
47regulation of membrane repolarization (GO:0060306)4.77218948
48regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.75497144
49muscle hypertrophy (GO:0014896)4.75323962
50regulation of secondary heart field cardioblast proliferation (GO:0003266)4.68710978
51regulation of cardioblast proliferation (GO:0003264)4.68710978
52regulation of cardiac muscle cell apoptotic process (GO:0010665)4.68122361
53outflow tract septum morphogenesis (GO:0003148)4.67115312
54negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.55330097
55* regulation of the force of heart contraction (GO:0002026)4.53915395
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.52028043
57cell communication by electrical coupling (GO:0010644)4.50689308
58positive regulation of cardiac muscle cell proliferation (GO:0060045)4.46725060
59regulation of cell communication by electrical coupling (GO:0010649)4.44521138
60negative regulation of striated muscle cell apoptotic process (GO:0010664)4.40984272
61regulation of cardiac muscle contraction (GO:0055117)4.40350737
62cell migration involved in heart development (GO:0060973)4.39255631
63regulation of cardiac muscle cell contraction (GO:0086004)4.37948859
64sarcoplasmic reticulum calcium ion transport (GO:0070296)4.36102490
65negative regulation of protein localization to cell surface (GO:2000009)4.34326971
66response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.30529921
67positive regulation of cardiac muscle tissue growth (GO:0055023)4.30055694
68cardiac muscle cell action potential involved in contraction (GO:0086002)4.28665113
69regulation of cardioblast differentiation (GO:0051890)4.28048776
70cardiac muscle cell action potential (GO:0086001)4.22439174
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.17240855
72fatty acid transmembrane transport (GO:1902001)4.15600658
73positive regulation of cardiac muscle tissue development (GO:0055025)4.13516951
74positive regulation of ATPase activity (GO:0032781)4.12778368
75positive regulation of ATP catabolic process (GO:1903291)4.12778368
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11553340
77regulation of acyl-CoA biosynthetic process (GO:0050812)4.11233477
78* regulation of heart rate (GO:0002027)4.08418044
79negative regulation of potassium ion transport (GO:0043267)4.06756017
80* actin filament-based movement (GO:0030048)4.04536045
81endocardial cushion development (GO:0003197)4.04070962
82muscle hypertrophy in response to stress (GO:0003299)3.94751370
83cardiac muscle adaptation (GO:0014887)3.94751370
84cardiac muscle hypertrophy in response to stress (GO:0014898)3.94751370
85* regulation of heart contraction (GO:0008016)3.93189956
86positive regulation of heart rate (GO:0010460)3.92349483
87regulation of cardiac muscle cell proliferation (GO:0060043)3.90623902
88cardiac right ventricle morphogenesis (GO:0003215)3.90540883
89ATP synthesis coupled proton transport (GO:0015986)3.87122604
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87122604
91NADH metabolic process (GO:0006734)3.85225834
92positive regulation of heart contraction (GO:0045823)3.85043252
93positive regulation of heart growth (GO:0060421)3.83820362
94relaxation of cardiac muscle (GO:0055119)3.79568248
95striated muscle adaptation (GO:0014888)3.79322281
962-oxoglutarate metabolic process (GO:0006103)3.75188682
97regulation of cofactor metabolic process (GO:0051193)3.73670863
98regulation of coenzyme metabolic process (GO:0051196)3.73670863
99* regulation of ATPase activity (GO:0043462)3.72310847
100* regulation of ATP catabolic process (GO:1903289)3.72310847
101positive regulation of cation channel activity (GO:2001259)3.69420713
102regulation of cardiac muscle tissue development (GO:0055024)3.66396248
103ventricular cardiac muscle cell development (GO:0055015)3.65492240
104adrenergic receptor signaling pathway (GO:0071875)3.64568597
105negative regulation of cytosolic calcium ion concentration (GO:0051481)3.64209821
106carnitine transmembrane transport (GO:1902603)3.63351631
107regulation of heart rate by cardiac conduction (GO:0086091)3.63285073
108cardiac septum development (GO:0003279)3.62465291
109embryonic heart tube development (GO:0035050)3.60096445
110cardiac conduction (GO:0061337)3.57763543
111creatine metabolic process (GO:0006600)3.56903977
112desmosome organization (GO:0002934)3.52979133
113regulation of striated muscle cell apoptotic process (GO:0010662)3.50595590
114trabecula formation (GO:0060343)3.49247602
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48847870
116regulation of sequestering of triglyceride (GO:0010889)3.48453406
117cellular response to epinephrine stimulus (GO:0071872)3.47966856
118regulation of muscle contraction (GO:0006937)3.46861289
119relaxation of muscle (GO:0090075)3.46471083
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46087528
121regulation of cardiac muscle tissue growth (GO:0055021)3.43508528
122respiratory electron transport chain (GO:0022904)3.43252427
123response to inactivity (GO:0014854)3.42679516
124cardiac muscle cell proliferation (GO:0060038)3.42481062
125potassium ion export (GO:0071435)3.36808973
126pericardium development (GO:0060039)3.36662077
127* striated muscle cell development (GO:0055002)3.36416264
128positive regulation of cardiac muscle cell differentiation (GO:2000727)3.36086288
129gap junction assembly (GO:0016264)3.35347428
130electron transport chain (GO:0022900)3.32500475
131regulation of calcium ion transmembrane transporter activity (GO:1901019)3.32285583
132regulation of calcium ion transmembrane transport (GO:1903169)3.32285583
133response to epinephrine (GO:0071871)3.31925244
134carnitine transport (GO:0015879)3.30541131
135amino-acid betaine transport (GO:0015838)3.30541131
136detection of calcium ion (GO:0005513)3.20521115
137negative regulation of hormone biosynthetic process (GO:0032353)3.18323711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.99107974
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.83844592
3TBX20_22080862_ChIP-Seq_HEART_Mouse4.13407195
4TBX20_22328084_ChIP-Seq_HEART_Mouse4.13407195
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.87586297
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.50343379
7ZNF263_19887448_ChIP-Seq_K562_Human3.38856702
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.22818957
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.97728400
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.97544246
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66033898
12EZH2_22144423_ChIP-Seq_EOC_Human2.59687418
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40736532
14* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.35563963
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33185945
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.29375798
17GATA4_21415370_ChIP-Seq_HL-1_Mouse2.22876623
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09580987
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.05221179
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.04436342
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96456006
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.93305077
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79457009
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79143213
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.73741154
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69348005
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64302640
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64302640
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60208496
30NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.59866006
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59016144
32DROSHA_22980978_ChIP-Seq_HELA_Human1.58366753
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54916056
34CLOCK_20551151_ChIP-Seq_293T_Human1.53663541
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50717117
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50693548
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50473055
38LXR_22292898_ChIP-Seq_THP-1_Human1.49208061
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.47681481
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.47034028
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46340648
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46290736
43KDM2B_26808549_Chip-Seq_DND41_Human1.46255847
44CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43757670
45CTCF_27219007_Chip-Seq_Bcells_Human1.39799328
46GATA1_22025678_ChIP-Seq_K562_Human1.39522657
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.39373664
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37057041
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.33871698
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33238428
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.33224324
52GATA1_19941826_ChIP-Seq_K562_Human1.32960016
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.32355605
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32036812
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31898452
56* TP63_22573176_ChIP-Seq_HFKS_Human1.30999683
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.30827104
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30000277
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29837523
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26950989
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26758167
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25685745
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25464124
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23823259
65VDR_22108803_ChIP-Seq_LS180_Human1.22713565
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21510720
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19644793
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18713617
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.18390864
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17920607
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.16477407
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14936204
73RACK7_27058665_Chip-Seq_MCF-7_Human1.13273366
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12920836
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12105828
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11147250
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09635431
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09300118
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08828178
80* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07800565
81SMAD4_21799915_ChIP-Seq_A2780_Human1.07650513
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.07326471
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07040389
84P68_20966046_ChIP-Seq_HELA_Human1.06581794
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05632139
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.05143213
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04875262
88KDM2B_26808549_Chip-Seq_K562_Human1.03721051
89ATF3_27146783_Chip-Seq_COLON_Human1.02876180
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02840333
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.02818676
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.02521522
93SPI1_23127762_ChIP-Seq_K562_Human1.01938782
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01258877
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00861281
96SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99762022
97SPI1_20517297_ChIP-Seq_HL60_Human0.99533283
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99017782
99TP53_16413492_ChIP-PET_HCT116_Human0.98811884
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98790541
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98679747
102NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98406723
103TP53_23651856_ChIP-Seq_MEFs_Mouse0.98000010
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97985926
105GBX2_23144817_ChIP-Seq_PC3_Human0.96786524
106RXR_22158963_ChIP-Seq_LIVER_Mouse0.96463042
107* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96343502
108GATA2_19941826_ChIP-Seq_K562_Human0.96184906
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95837591
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95673183
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95630574
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.93785623
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92572769
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92239784
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92113715
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92028485
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91770390
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.91109044
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91071187
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90356892
121SMC4_20622854_ChIP-Seq_HELA_Human0.89444592
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89272409
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.88312970
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88049286
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86695463
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.86528955
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85362934
128CREB1_26743006_Chip-Seq_LNCaP_Human0.85350162
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85054663
130GF1_26923725_Chip-Seq_HPCs_Mouse0.85038825
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84984492
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84984492
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84902529
134TBL1_22424771_ChIP-Seq_293T_Human0.84773374
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84698581
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84458479
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84409301
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84327322
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83811739
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83576689
141OCT4_20526341_ChIP-Seq_ESCs_Human0.83337731
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.83271308
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83128885
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83005351
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81934556
146EOMES_21245162_ChIP-Seq_HESCs_Human0.81634784
147AHR_22903824_ChIP-Seq_MCF-7_Human0.81318009
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80292439
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80134074
150MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79676815
151CTCF_21964334_Chip-Seq_Bcells_Human0.79431862
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79225519
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78844247
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78753437
155SOX9_26525672_Chip-Seq_HEART_Mouse0.77896697
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77689992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002837_dystrophic_cardiac_calcinosis6.37935883
2MP0003646_muscle_fatigue5.98247198
3* MP0004084_abnormal_cardiac_muscle5.68026920
4MP0000751_myopathy5.40924270
5* MP0004215_abnormal_myocardial_fiber4.88342792
6* MP0004036_abnormal_muscle_relaxation4.02657994
7* MP0005330_cardiomyopathy3.85273054
8MP0000749_muscle_degeneration3.77000549
9* MP0002972_abnormal_cardiac_muscle3.29536302
10MP0003137_abnormal_impulse_conducting3.25020009
11MP0008775_abnormal_heart_ventricle3.17310759
12* MP0004087_abnormal_muscle_fiber3.04755405
13MP0006138_congestive_heart_failure2.84795021
14MP0000750_abnormal_muscle_regeneration2.80505062
15* MP0005385_cardiovascular_system_phenoty2.76022632
16* MP0001544_abnormal_cardiovascular_syste2.76022632
17* MP0010630_abnormal_cardiac_muscle2.70244843
18* MP0005620_abnormal_muscle_contractility2.62121452
19MP0003828_pulmonary_edema2.58854809
20MP0002106_abnormal_muscle_physiology2.41283201
21MP0004484_altered_response_of2.38333368
22MP0002269_muscular_atrophy2.26610706
23MP0004130_abnormal_muscle_cell2.23651002
24* MP0004085_abnormal_heartbeat2.22480158
25MP0004510_myositis2.18167484
26MP0005369_muscle_phenotype1.95116456
27MP0003221_abnormal_cardiomyocyte_apopto1.93821818
28MP0000759_abnormal_skeletal_muscle1.85303418
29MP0002127_abnormal_cardiovascular_syste1.80253303
30MP0000747_muscle_weakness1.72250626
31MP0003950_abnormal_plasma_membrane1.69765713
32MP0004233_abnormal_muscle_weight1.62611120
33MP0004145_abnormal_muscle_electrophysio1.58214336
34MP0005670_abnormal_white_adipose1.52044707
35MP0005666_abnormal_adipose_tissue1.46846188
36MP0006036_abnormal_mitochondrial_physio1.44169162
37MP0010368_abnormal_lymphatic_system1.43204865
38MP0003279_aneurysm1.37508297
39MP0003567_abnormal_fetal_cardiomyocyte1.33186931
40MP0003941_abnormal_skin_development1.31667146
41MP0002332_abnormal_exercise_endurance1.29457804
42MP0000343_altered_response_to1.22029933
43* MP0000266_abnormal_heart_morphology1.19383492
44MP0002234_abnormal_pharynx_morphology1.15005535
45MP0005165_increased_susceptibility_to1.12343501
46MP0000537_abnormal_urethra_morphology1.05856179
47MP0005623_abnormal_meninges_morphology1.02579498
48MP0005503_abnormal_tendon_morphology1.02551600
49MP0001661_extended_life_span1.02247908
50MP0002102_abnormal_ear_morphology0.99587954
51MP0005375_adipose_tissue_phenotype0.98968326
52MP0003705_abnormal_hypodermis_morpholog0.97074481
53MP0004185_abnormal_adipocyte_glucose0.93917432
54MP0003566_abnormal_cell_adhesion0.91346193
55* MP0002128_abnormal_blood_circulation0.87943268
56MP0000230_abnormal_systemic_arterial0.84608794
57MP0006035_abnormal_mitochondrial_morpho0.84130976
58MP0000462_abnormal_digestive_system0.80959534
59MP0005266_abnormal_metabolism0.80518731
60MP0000767_abnormal_smooth_muscle0.80466151
61MP0008004_abnormal_stomach_pH0.76909456
62MP0001879_abnormal_lymphatic_vessel0.75124075
63MP0002108_abnormal_muscle_morphology0.74889362
64MP0002909_abnormal_adrenal_gland0.74576598
65MP0005451_abnormal_body_composition0.70936157
66MP0008438_abnormal_cutaneous_collagen0.69450258
67MP0004272_abnormal_basement_membrane0.67723589
68MP0003937_abnormal_limbs/digits/tail_de0.65751373
69MP0005187_abnormal_penis_morphology0.64982681
70MP0003806_abnormal_nucleotide_metabolis0.64202161
71MP0002925_abnormal_cardiovascular_devel0.56477506
72MP0005367_renal/urinary_system_phenotyp0.54584882
73MP0000516_abnormal_urinary_system0.54584882
74MP0000003_abnormal_adipose_tissue0.53480541
75MP0005248_abnormal_Harderian_gland0.53354222
76MP0003385_abnormal_body_wall0.50458412
77MP0005319_abnormal_enzyme/_coenzyme0.48501905
78MP0003984_embryonic_growth_retardation0.47827963
79MP0009250_abnormal_appendicular_skeleto0.47615077
80MP0002088_abnormal_embryonic_growth/wei0.46192816
81MP0005275_abnormal_skin_tensile0.43985622
82MP0001299_abnormal_eye_distance/0.43284868
83MP0001614_abnormal_blood_vessel0.42701043
84MP0000733_abnormal_muscle_development0.42673102
85MP0001784_abnormal_fluid_regulation0.42236952
86MP0002078_abnormal_glucose_homeostasis0.41686575
87MP0000579_abnormal_nail_morphology0.41252200
88MP0008961_abnormal_basal_metabolism0.40983604
89MP0003935_abnormal_craniofacial_develop0.40979217
90MP0000013_abnormal_adipose_tissue0.40764838
91MP0002249_abnormal_larynx_morphology0.40483937
92MP0001958_emphysema0.40086011
93MP0004043_abnormal_pH_regulation0.39600777
94MP0001730_embryonic_growth_arrest0.39233960
95MP0000762_abnormal_tongue_morphology0.38850221
96MP0009840_abnormal_foam_cell0.38235015
97MP0000534_abnormal_ureter_morphology0.36523591
98MP0002971_abnormal_brown_adipose0.35467769
99MP0005595_abnormal_vascular_smooth0.35252625
100MP0003948_abnormal_gas_homeostasis0.34573013
101MP0009384_cardiac_valve_regurgitation0.33872942
102MP0005167_abnormal_blood-brain_barrier0.33849132
103MP0002295_abnormal_pulmonary_circulatio0.33779258
104MP0002822_catalepsy0.33500666
105MP0004147_increased_porphyrin_level0.32074059
106MP0004924_abnormal_behavior0.30075131
107MP0005386_behavior/neurological_phenoty0.30075131
108MP0005083_abnormal_biliary_tract0.28675619
109MP0005535_abnormal_body_temperature0.28290250
110MP0003942_abnormal_urinary_system0.27332215
111MP0002133_abnormal_respiratory_system0.26513231
112MP0005388_respiratory_system_phenotype0.26513231
113MP0000249_abnormal_blood_vessel0.26481722
114MP0009780_abnormal_chondrocyte_physiolo0.26463143
115MP0001672_abnormal_embryogenesis/_devel0.25669029
116MP0005380_embryogenesis_phenotype0.25669029
117MP0003119_abnormal_digestive_system0.25064132
118MP0005334_abnormal_fat_pad0.24811237
119MP0002118_abnormal_lipid_homeostasis0.23773337
120MP0003045_fibrosis0.23657044
121MP0001727_abnormal_embryo_implantation0.23610279
122MP0001697_abnormal_embryo_size0.23470897
123MP0002086_abnormal_extraembryonic_tissu0.23324807
124MP0009115_abnormal_fat_cell0.23152453
125MP0006072_abnormal_retinal_apoptosis0.22690130
126MP0005409_darkened_coat_color0.22566073
127MP0002970_abnormal_white_adipose0.18882543

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)9.27414733
2Ventricular tachycardia (HP:0004756)7.76237615
3Atrial fibrillation (HP:0005110)6.66329007
4Calf muscle hypertrophy (HP:0008981)6.43520975
5Primary atrial arrhythmia (HP:0001692)6.24000108
6Muscle fiber splitting (HP:0003555)6.14850634
7Supraventricular tachycardia (HP:0004755)6.03990342
8Supraventricular arrhythmia (HP:0005115)5.93498353
9Muscle hypertrophy of the lower extremities (HP:0008968)5.72624373
10* Lipoatrophy (HP:0100578)5.71603709
11Abnormality of the left ventricular outflow tract (HP:0011103)5.69114974
12Subaortic stenosis (HP:0001682)5.69114974
13Abnormality of the calf musculature (HP:0001430)5.50657379
14Right ventricular cardiomyopathy (HP:0011663)5.47239349
15Exercise-induced muscle cramps (HP:0003710)5.25734074
16Syncope (HP:0001279)5.19627299
17Hyporeflexia of lower limbs (HP:0002600)5.13186112
18Exercise-induced myalgia (HP:0003738)5.06246741
19Bundle branch block (HP:0011710)4.95933591
20Prolonged QT interval (HP:0001657)4.84140160
21Palpitations (HP:0001962)4.70902667
22* Dilated cardiomyopathy (HP:0001644)4.63443163
23Asymmetric septal hypertrophy (HP:0001670)4.38729966
24EMG: myopathic abnormalities (HP:0003458)4.35133819
25Ventricular arrhythmia (HP:0004308)4.33686302
26Ventricular fibrillation (HP:0001663)4.23072359
27Atrioventricular block (HP:0001678)4.16309264
28Heart block (HP:0012722)4.14156347
29Increased connective tissue (HP:0009025)4.10192213
30Myoglobinuria (HP:0002913)4.05960837
31Hypoplastic heart (HP:0001961)3.96727281
32Abnormal atrioventricular conduction (HP:0005150)3.91421656
33Bradycardia (HP:0001662)3.72776758
34Myotonia (HP:0002486)3.45750926
35Abnormal EKG (HP:0003115)3.45279586
36Difficulty running (HP:0009046)3.26967323
37Left ventricular hypertrophy (HP:0001712)3.08001733
38Rhabdomyolysis (HP:0003201)3.01501520
39Difficulty climbing stairs (HP:0003551)2.99453333
40Hip contracture (HP:0003273)2.88696961
41Transposition of the great arteries (HP:0001669)2.88490332
42Abnormal connection of the cardiac segments (HP:0011545)2.88490332
43Abnormal ventriculo-arterial connection (HP:0011563)2.88490332
44Periauricular skin pits (HP:0100277)2.81651316
45Preauricular pit (HP:0004467)2.81651316
46* Palmoplantar keratoderma (HP:0000982)2.79659681
47Testicular atrophy (HP:0000029)2.79548121
48Patent foramen ovale (HP:0001655)2.78801318
49Partial duplication of thumb phalanx (HP:0009944)2.64123276
50Hepatic necrosis (HP:0002605)2.60873118
51Ketoacidosis (HP:0001993)2.60842172
52Skin pits (HP:0100276)2.60413616
53Abnormal mitochondria in muscle tissue (HP:0008316)2.55930804
54Ragged-red muscle fibers (HP:0003200)2.55113280
55Acute necrotizing encephalopathy (HP:0006965)2.53972060
56Limb-girdle muscle atrophy (HP:0003797)2.52498291
57Aplasia of the musculature (HP:0100854)2.50185735
58Distal lower limb muscle weakness (HP:0009053)2.43802932
59Abnormality of the foot musculature (HP:0001436)2.40587247
60Increased variability in muscle fiber diameter (HP:0003557)2.37189156
61Hepatocellular necrosis (HP:0001404)2.32069509
62Partial duplication of the phalanx of hand (HP:0009999)2.31170918
63Sudden cardiac death (HP:0001645)2.28477165
64Mildly elevated creatine phosphokinase (HP:0008180)2.27922500
65Neck muscle weakness (HP:0000467)2.27648153
66Anomalous pulmonary venous return (HP:0010772)2.25620042
67Hypoglycemic coma (HP:0001325)2.24973315
68Dysmetric saccades (HP:0000641)2.24336332
69Rimmed vacuoles (HP:0003805)2.21533440
70Truncus arteriosus (HP:0001660)2.20293974
71Acute encephalopathy (HP:0006846)2.19179037
72Areflexia of lower limbs (HP:0002522)2.18987200
73Congestive heart failure (HP:0001635)2.16993186
74Distal lower limb amyotrophy (HP:0008944)2.16833865
75Foot dorsiflexor weakness (HP:0009027)2.15672734
76Increased muscle lipid content (HP:0009058)2.14005577
77Conjunctival hamartoma (HP:0100780)2.13689690
78Abnormality of fatty-acid metabolism (HP:0004359)2.12212225
79Limited hip movement (HP:0008800)2.12155658
80Mitochondrial inheritance (HP:0001427)2.11748728
81Large for gestational age (HP:0001520)2.08153172
82Abnormality of skeletal muscle fiber size (HP:0012084)2.06650268
83Cerebral edema (HP:0002181)2.06335657
84Progressive macrocephaly (HP:0004481)2.05540105
85Dicarboxylic aciduria (HP:0003215)2.04338059
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04338059
87Vitreoretinal degeneration (HP:0000655)2.02135430
88EMG: neuropathic changes (HP:0003445)1.97184152
89Pulmonary artery stenosis (HP:0004415)1.96044983
90Pheochromocytoma (HP:0002666)1.96006779
91Hyperinsulinemic hypoglycemia (HP:0000825)1.94616771
92Congenital malformation of the right heart (HP:0011723)1.93973720
93Double outlet right ventricle (HP:0001719)1.93973720
94Increased CSF lactate (HP:0002490)1.93625778
95Ketosis (HP:0001946)1.93587113
96Type 1 muscle fiber predominance (HP:0003803)1.93007936
97Muscle stiffness (HP:0003552)1.92644140
98Abnormality of the pulmonary veins (HP:0011718)1.92602341
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91811263
100Muscular dystrophy (HP:0003560)1.91025521
101Steppage gait (HP:0003376)1.88975816
102Broad metatarsal (HP:0001783)1.88270860
103Hamartoma of the eye (HP:0010568)1.88121883
104Hypoplastic ischia (HP:0003175)1.85571994
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.85357677
106Abnormality of the tricuspid valve (HP:0001702)1.84759416
107Respiratory failure (HP:0002878)1.84314452
108Abnormality of the ischium (HP:0003174)1.83370047
109Diaphragmatic weakness (HP:0009113)1.82407788
110Maternal diabetes (HP:0009800)1.81921102
111Exercise intolerance (HP:0003546)1.81149508
112Increased intramyocellular lipid droplets (HP:0012240)1.80888481
113Lymphangioma (HP:0100764)1.80477074
114Scapular winging (HP:0003691)1.79851761
115Metaphyseal cupping (HP:0003021)1.79397902
116Resting tremor (HP:0002322)1.79029130
117Esophageal neoplasm (HP:0100751)1.77725569
118Neoplasm of head and neck (HP:0012288)1.77725569
119Muscle fiber inclusion bodies (HP:0100299)1.76166422
120Lactic acidosis (HP:0003128)1.74626704
121Gowers sign (HP:0003391)1.74445160
122Complete atrioventricular canal defect (HP:0001674)1.74221812
123Generalized muscle weakness (HP:0003324)1.73515568
124Neoplasm of the adrenal gland (HP:0100631)1.72841733
125Hypoplastic left heart (HP:0004383)1.71220053
126Neuroendocrine neoplasm (HP:0100634)1.71043339
127Lower limb amyotrophy (HP:0007210)1.70019547
128Toxemia of pregnancy (HP:0100603)1.65209820
129Coarctation of aorta (HP:0001680)1.56106637
130Aneurysm (HP:0002617)1.53599663
131Bicuspid aortic valve (HP:0001647)1.53575673
132Skin nodule (HP:0200036)1.51421942
133Prenatal maternal abnormality (HP:0002686)1.50688480
134Limb hypertonia (HP:0002509)1.47675699
135Abnormality of the shoulder girdle musculature (HP:0001435)1.47591213
136Abnormality of the endocardium (HP:0004306)1.46723537
137Late onset (HP:0003584)1.46334106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.79668380
2LMTK24.63352059
3MYLK4.44483649
4PHKG23.90870779
5PHKG13.90870779
6OBSCN3.69101473
7DMPK3.36308292
8PKN22.97803797
9PDK42.88497360
10PDK32.88497360
11TRIB32.79395240
12MUSK2.66145986
13PIK3CA2.59118379
14BCKDK2.32854760
15TIE12.29640677
16NEK11.93305629
17NEK91.86510528
18PAK31.74061623
19DDR21.68243084
20PDK21.66541325
21PINK11.64352871
22PRKD11.57767915
23STK241.51965407
24CAMK2D1.46696744
25CDC42BPA1.45462509
26STK41.27261800
27ROCK11.24963847
28LATS11.23523549
29ILK1.22969617
30RIPK11.18327008
31DAPK31.14601174
32GRK71.10895631
33MAP3K51.10035691
34WNK41.06323381
35MARK11.05169360
36MAPKAPK31.03485542
37PKN11.01283981
38UHMK10.93566373
39MAPK120.93312099
40PDGFRA0.92976991
41LIMK10.88404939
42PRKAA10.83867578
43EPHB10.83696998
44INSRR0.83220525
45ROCK20.83015817
46MAP3K70.80867659
47RPS6KL10.80212112
48RPS6KC10.80212112
49PRKAA20.77525520
50ZAK0.75423319
51KDR0.75275256
52STK380.74582646
53TRPM70.71827719
54PTK2B0.70946141
55MAP3K60.70752609
56CAMK40.70394708
57FLT30.70237057
58RPS6KA60.70061917
59STK38L0.69063904
60ICK0.68644039
61TGFBR20.68137596
62MAPK40.64023969
63CAMK2A0.63164041
64SIK10.61780512
65PRKCE0.60954660
66WNK10.59859936
67PRKACB0.56433125
68MAP3K30.56171323
69MAP2K30.53538774
70FGFR10.50861304
71CAMK10.49708309
72AKT30.48801273
73ITK0.47040751
74PRKACG0.44358815
75CAMK2B0.43366733
76PRKCH0.43255245
77PRKACA0.41304799
78PTK60.40797359
79DYRK1B0.40260844
80NLK0.39995701
81PDPK10.38050576
82EPHB20.37900799
83PRKD30.37746303
84MTOR0.34462996
85PRKG20.32843072
86KSR20.32243186
87MAP2K10.31912859
88RPS6KB20.31529788
89PTK20.30910470
90PAK20.29488008
91FER0.29198889
92RPS6KA10.28433999
93AKT20.27376246
94RAF10.27354606
95RPS6KA20.26967136
96PDK10.25621941
97CDK40.25309125
98STK390.24899349
99LATS20.24065676
100MAPK100.23979217
101FGFR40.23632309
102JAK10.23349009
103MAP3K100.23346209
104PIK3CG0.23268196
105SGK30.22566060
106KSR10.22558958
107CAMK2G0.21234258
108CDK50.20257143
109TGFBR10.19537976
110TAOK10.19473292
111RET0.19150663
112MARK20.19052424
113PRKG10.18831191
114EEF2K0.18618882
115CAMK1D0.17885166
116PDGFRB0.17610265
117EPHA30.17394101
118CAMK1G0.17306466
119FGFR30.16782770
120EPHA40.16594815
121RPS6KA30.16036078
122PRKD20.15818072
123ADRBK10.15494981
124LRRK20.15203161
125PAK60.14986030
126MAPKAPK20.13853261
127MAPK70.12174331
128MAP3K10.10059469
129STK110.09958016

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.55433906
2* Cardiac muscle contraction_Homo sapiens_hsa042604.49250321
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.28267676
4* Dilated cardiomyopathy_Homo sapiens_hsa054144.14062053
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.95553596
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.65578360
7Parkinsons disease_Homo sapiens_hsa050123.08870039
8Oxidative phosphorylation_Homo sapiens_hsa001903.00670091
9Propanoate metabolism_Homo sapiens_hsa006402.97190038
10Fatty acid degradation_Homo sapiens_hsa000712.71811304
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.58636344
12Carbon metabolism_Homo sapiens_hsa012002.32528745
13Alzheimers disease_Homo sapiens_hsa050102.28719689
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08383286
15Fatty acid metabolism_Homo sapiens_hsa012122.04473143
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00867142
17Huntingtons disease_Homo sapiens_hsa050161.90934310
18* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86971942
19Pyruvate metabolism_Homo sapiens_hsa006201.67198188
20* Viral myocarditis_Homo sapiens_hsa054161.53885777
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36442989
22Butanoate metabolism_Homo sapiens_hsa006501.34403783
23PPAR signaling pathway_Homo sapiens_hsa033201.19578746
24Fatty acid elongation_Homo sapiens_hsa000621.16796337
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08625336
26Biosynthesis of amino acids_Homo sapiens_hsa012301.08389564
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06625762
28Insulin resistance_Homo sapiens_hsa049311.05150172
29Lysine degradation_Homo sapiens_hsa003101.00907940
30Adipocytokine signaling pathway_Homo sapiens_hsa049200.98643684
31Glucagon signaling pathway_Homo sapiens_hsa049220.97131684
32Tryptophan metabolism_Homo sapiens_hsa003800.91987760
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91357429
34Starch and sucrose metabolism_Homo sapiens_hsa005000.90410641
35Arginine biosynthesis_Homo sapiens_hsa002200.90036285
36Protein digestion and absorption_Homo sapiens_hsa049740.87852640
37Type II diabetes mellitus_Homo sapiens_hsa049300.83413170
38Insulin signaling pathway_Homo sapiens_hsa049100.82824754
39Focal adhesion_Homo sapiens_hsa045100.82680102
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81719561
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80806763
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75701673
43Calcium signaling pathway_Homo sapiens_hsa040200.72232795
44TGF-beta signaling pathway_Homo sapiens_hsa043500.71247834
45beta-Alanine metabolism_Homo sapiens_hsa004100.67463200
46ECM-receptor interaction_Homo sapiens_hsa045120.66982807
47HIF-1 signaling pathway_Homo sapiens_hsa040660.65955726
48Arginine and proline metabolism_Homo sapiens_hsa003300.64891567
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63098770
50AMPK signaling pathway_Homo sapiens_hsa041520.62269283
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.62265517
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61941377
53Fatty acid biosynthesis_Homo sapiens_hsa000610.60516811
54Phenylalanine metabolism_Homo sapiens_hsa003600.55472839
55Melanogenesis_Homo sapiens_hsa049160.55407612
56Hippo signaling pathway_Homo sapiens_hsa043900.54732138
57Oxytocin signaling pathway_Homo sapiens_hsa049210.52873207
58cAMP signaling pathway_Homo sapiens_hsa040240.52454075
59Renin secretion_Homo sapiens_hsa049240.50641842
60Morphine addiction_Homo sapiens_hsa050320.50417094
61Insulin secretion_Homo sapiens_hsa049110.50088240
62Pentose phosphate pathway_Homo sapiens_hsa000300.50008675
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49990946
64Amphetamine addiction_Homo sapiens_hsa050310.47558860
65* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47139153
66Amoebiasis_Homo sapiens_hsa051460.47134970
67* Tight junction_Homo sapiens_hsa045300.45379706
68Galactose metabolism_Homo sapiens_hsa000520.44230631
69Adherens junction_Homo sapiens_hsa045200.43986209
70GABAergic synapse_Homo sapiens_hsa047270.43752218
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.43513061
72Endometrial cancer_Homo sapiens_hsa052130.42978064
73Thyroid hormone synthesis_Homo sapiens_hsa049180.42009643
74Gastric acid secretion_Homo sapiens_hsa049710.41722288
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41597694
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41198766
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40723862
78Peroxisome_Homo sapiens_hsa041460.40217949
79Cocaine addiction_Homo sapiens_hsa050300.39428692
80Prion diseases_Homo sapiens_hsa050200.38795780
81Fructose and mannose metabolism_Homo sapiens_hsa000510.37269711
82Circadian entrainment_Homo sapiens_hsa047130.36078118
83Basal cell carcinoma_Homo sapiens_hsa052170.32535250
84Hedgehog signaling pathway_Homo sapiens_hsa043400.32206383
85Mineral absorption_Homo sapiens_hsa049780.31503102
86Ovarian steroidogenesis_Homo sapiens_hsa049130.26499660
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26270756
88Pathways in cancer_Homo sapiens_hsa052000.25156693
89Dorso-ventral axis formation_Homo sapiens_hsa043200.24794986
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24638131
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.24110519
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23251016
93Notch signaling pathway_Homo sapiens_hsa043300.22760293
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22366372
95Gap junction_Homo sapiens_hsa045400.21111573
96Taste transduction_Homo sapiens_hsa047420.20732620
97Serotonergic synapse_Homo sapiens_hsa047260.20711581
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20640569
99Renal cell carcinoma_Homo sapiens_hsa052110.20064513
100Dopaminergic synapse_Homo sapiens_hsa047280.19819549
101Proteoglycans in cancer_Homo sapiens_hsa052050.19413889
102Bile secretion_Homo sapiens_hsa049760.19261536
103Metabolic pathways_Homo sapiens_hsa011000.18932416
104Platelet activation_Homo sapiens_hsa046110.18592693
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.18421296
106Fat digestion and absorption_Homo sapiens_hsa049750.17130956
107Pancreatic secretion_Homo sapiens_hsa049720.16551381
108VEGF signaling pathway_Homo sapiens_hsa043700.16411851
109GnRH signaling pathway_Homo sapiens_hsa049120.15509612
110Tyrosine metabolism_Homo sapiens_hsa003500.13663044
111Cholinergic synapse_Homo sapiens_hsa047250.11131607
112Small cell lung cancer_Homo sapiens_hsa052220.10242669
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10205461
114Estrogen signaling pathway_Homo sapiens_hsa049150.09912066
115Circadian rhythm_Homo sapiens_hsa047100.06663796
116Salivary secretion_Homo sapiens_hsa049700.06257091
117Toxoplasmosis_Homo sapiens_hsa051450.05967134
118Glycerolipid metabolism_Homo sapiens_hsa005610.04545943
119mTOR signaling pathway_Homo sapiens_hsa041500.03663306
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.03524288

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