MYH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.96887175
2sarcomere organization (GO:0045214)9.86183704
3myofibril assembly (GO:0030239)8.68572741
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.59931766
5* actin-myosin filament sliding (GO:0033275)8.22920418
6* muscle filament sliding (GO:0030049)8.22920418
7negative regulation of potassium ion transmembrane transport (GO:1901380)7.90050973
8cardiac muscle cell development (GO:0055013)7.35772525
9cardiac muscle contraction (GO:0060048)7.32607264
10skeletal muscle contraction (GO:0003009)7.12619936
11cardiac cell development (GO:0055006)6.92198359
12* actin-mediated cell contraction (GO:0070252)6.82236260
13* cardiac muscle tissue morphogenesis (GO:0055008)6.63253735
14* ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.58469646
15actomyosin structure organization (GO:0031032)6.53624776
16cardiac muscle hypertrophy (GO:0003300)6.32509844
17* adult heart development (GO:0007512)6.18631033
18plasma membrane repair (GO:0001778)6.13566190
19negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.12468108
20regulation of actin filament-based movement (GO:1903115)6.03045545
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.00995380
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.98351094
23striated muscle hypertrophy (GO:0014897)5.98032779
24regulation of sarcomere organization (GO:0060297)5.95330850
25ventricular cardiac muscle cell action potential (GO:0086005)5.93751270
26* muscle tissue morphogenesis (GO:0060415)5.88892473
27heart trabecula formation (GO:0060347)5.83554227
28creatine metabolic process (GO:0006600)5.71800502
29heart process (GO:0003015)5.66579021
30heart contraction (GO:0060047)5.66579021
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.57186883
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.57006960
33bundle of His cell to Purkinje myocyte communication (GO:0086069)5.50523094
34* striated muscle contraction (GO:0006941)5.48464551
35tricarboxylic acid cycle (GO:0006099)5.45733147
36response to inactivity (GO:0014854)5.44928241
37negative regulation of striated muscle cell apoptotic process (GO:0010664)5.44116522
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.41994674
39regulation of cardioblast differentiation (GO:0051890)5.33698499
40muscle hypertrophy (GO:0014896)5.31609369
41regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.29330553
42regulation of striated muscle contraction (GO:0006942)5.17015234
43* actin filament-based movement (GO:0030048)5.15225137
44regulation of relaxation of muscle (GO:1901077)5.12156279
45NADH metabolic process (GO:0006734)5.10759651
46cardiac muscle hypertrophy in response to stress (GO:0014898)4.96606143
47muscle hypertrophy in response to stress (GO:0003299)4.96606143
48cardiac muscle adaptation (GO:0014887)4.96606143
49regulation of skeletal muscle contraction (GO:0014819)4.91865235
50ventricular cardiac muscle cell development (GO:0055015)4.90467462
51* regulation of the force of heart contraction (GO:0002026)4.88717445
52response to muscle activity (GO:0014850)4.86143459
53regulation of membrane repolarization (GO:0060306)4.83738810
54negative regulation of protein localization to cell surface (GO:2000009)4.79669021
55cell communication involved in cardiac conduction (GO:0086065)4.73177105
56cell communication by electrical coupling (GO:0010644)4.70484463
57carnitine shuttle (GO:0006853)4.48159950
58cardiac muscle cell action potential involved in contraction (GO:0086002)4.25956236
59negative regulation of potassium ion transport (GO:0043267)4.25822320
60regulation of striated muscle cell apoptotic process (GO:0010662)4.22409800
61cardiac chamber formation (GO:0003207)4.18791939
62cardiac muscle cell action potential (GO:0086001)4.16585067
63regulation of cardiac muscle contraction (GO:0055117)4.16330770
64regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.15989243
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11670956
66striated muscle cell development (GO:0055002)4.10919078
67atrial septum morphogenesis (GO:0060413)4.10655159
68regulation of ATPase activity (GO:0043462)4.08749134
69regulation of ATP catabolic process (GO:1903289)4.08749134
70regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.07779786
71skeletal muscle adaptation (GO:0043501)4.01648224
72regulation of cell communication by electrical coupling (GO:0010649)4.00438808
73* regulation of heart rate (GO:0002027)3.99874701
74regulation of calcium ion transmembrane transport (GO:1903169)3.96964314
75regulation of calcium ion transmembrane transporter activity (GO:1901019)3.96964314
76trabecula formation (GO:0060343)3.95964379
77muscle fiber development (GO:0048747)3.86678109
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84904274
79ATP synthesis coupled proton transport (GO:0015986)3.84904274
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84198079
81membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.83932749
82regulation of cardiac muscle cell apoptotic process (GO:0010665)3.82243076
83sarcoplasmic reticulum calcium ion transport (GO:0070296)3.81385729
84* regulation of heart contraction (GO:0008016)3.79305116
85fatty acid transmembrane transport (GO:1902001)3.73130225
86outflow tract septum morphogenesis (GO:0003148)3.72222279
87regulation of cardiac muscle cell contraction (GO:0086004)3.71701053
88regulation of acyl-CoA biosynthetic process (GO:0050812)3.69932843
89skeletal muscle fiber development (GO:0048741)3.69679200
902-oxoglutarate metabolic process (GO:0006103)3.67387573
91negative regulation of cytosolic calcium ion concentration (GO:0051481)3.66571849
92relaxation of cardiac muscle (GO:0055119)3.66505237
93regulation of heart rate by cardiac conduction (GO:0086091)3.65787499
94regulation of muscle system process (GO:0090257)3.62522753
95negative regulation of calcium ion transmembrane transport (GO:1903170)3.62098906
96negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.62098906
97regulation of muscle contraction (GO:0006937)3.61235138
98cardiac ventricle formation (GO:0003211)3.60177892
99cardiac conduction (GO:0061337)3.57685898
100striated muscle adaptation (GO:0014888)3.55138935
101muscle cell development (GO:0055001)3.54606708
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.51527394
103negative regulation of myotube differentiation (GO:0010832)3.50357568
104positive regulation of potassium ion transmembrane transport (GO:1901381)3.50310400
105regulation of sequestering of triglyceride (GO:0010889)3.49417382
106potassium ion export (GO:0071435)3.47105622
107response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.47050966
108myotube cell development (GO:0014904)3.46980545
109muscle adaptation (GO:0043500)3.46174404
110response to caffeine (GO:0031000)3.45933018
111regulation of cofactor metabolic process (GO:0051193)3.45553132
112regulation of coenzyme metabolic process (GO:0051196)3.45553132
113positive regulation of cation channel activity (GO:2001259)3.45133321
114glycogen catabolic process (GO:0005980)3.43263491
115skeletal muscle tissue development (GO:0007519)3.42446681
116relaxation of muscle (GO:0090075)3.42380744
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.42090572
118detection of calcium ion (GO:0005513)3.41981569
119* muscle contraction (GO:0006936)3.41133177
120membrane repolarization during action potential (GO:0086011)3.40626435
121regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40138844
122positive regulation of heart rate (GO:0010460)3.36682777
123glycogen biosynthetic process (GO:0005978)3.31574299
124glucan biosynthetic process (GO:0009250)3.31574299
125muscle cell cellular homeostasis (GO:0046716)3.29392343
126negative regulation of cardiac muscle hypertrophy (GO:0010614)3.28828255
127cardiac right ventricle morphogenesis (GO:0003215)3.27462486
128cardiac muscle cell proliferation (GO:0060038)3.26806111
129regulation of potassium ion transmembrane transporter activity (GO:1901016)3.25540127
130* muscle system process (GO:0003012)3.22902308
131carnitine transmembrane transport (GO:1902603)3.22653159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse5.97806381
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.62980611
3TBX20_22080862_ChIP-Seq_HEART_Mouse4.44634871
4TBX20_22328084_ChIP-Seq_HEART_Mouse4.44634871
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32656497
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.18570568
7* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.80347111
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.18416323
9* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.16529508
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.15111155
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92735622
12ZNF263_19887448_ChIP-Seq_K562_Human2.87893370
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.86194702
14GATA4_21415370_ChIP-Seq_HL-1_Mouse2.71137293
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.62392177
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29741595
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97466247
18NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.96337453
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95448351
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.92361679
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92127115
22ISL1_27105846_Chip-Seq_CPCs_Mouse1.82572726
23CLOCK_20551151_ChIP-Seq_293T_Human1.77175066
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.76790815
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75682087
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72132482
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71958846
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66912871
29PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.64873939
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59262049
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54888537
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53883725
33EZH2_22144423_ChIP-Seq_EOC_Human1.53750534
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50288177
35GATA1_22025678_ChIP-Seq_K562_Human1.48289976
36GATA1_19941826_ChIP-Seq_K562_Human1.45664358
37KDM2B_26808549_Chip-Seq_DND41_Human1.41820463
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41567303
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41359392
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38778928
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35648141
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.35584837
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30715711
44DROSHA_22980978_ChIP-Seq_HELA_Human1.29488549
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29473441
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26830865
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26313890
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23110395
49TP63_22573176_ChIP-Seq_HFKS_Human1.22256749
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21419090
51* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21323433
52VDR_22108803_ChIP-Seq_LS180_Human1.19776497
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18472056
54* CTCF_27219007_Chip-Seq_Bcells_Human1.16501809
55RACK7_27058665_Chip-Seq_MCF-7_Human1.14893353
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.14829238
57LXR_22292898_ChIP-Seq_THP-1_Human1.10896092
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09879493
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09864928
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08668649
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.06890584
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05253152
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04796169
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03826429
65ATF3_27146783_Chip-Seq_COLON_Human1.03070148
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03065855
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02568639
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01993234
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00023706
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98914853
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97632746
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97629286
73* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97555417
74NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97210924
75WT1_19549856_ChIP-ChIP_CCG9911_Human0.96920505
76LXR_22158963_ChIP-Seq_LIVER_Mouse0.96285306
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95145860
78SPI1_20517297_ChIP-Seq_HL60_Human0.95140523
79STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93521968
80EZH2_27304074_Chip-Seq_ESCs_Mouse0.93465249
81* RARB_27405468_Chip-Seq_BRAIN_Mouse0.93045103
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.92477070
83RXR_22158963_ChIP-Seq_LIVER_Mouse0.92310081
84SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91390331
85RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91169245
86EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91169245
87SPI1_23127762_ChIP-Seq_K562_Human0.88572099
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88568879
89KDM2B_26808549_Chip-Seq_K562_Human0.87794102
90FOXA2_19822575_ChIP-Seq_HepG2_Human0.87660351
91* TP53_23651856_ChIP-Seq_MEFs_Mouse0.87429215
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.87345406
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87170555
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86135653
95GATA2_19941826_ChIP-Seq_K562_Human0.86032052
96MYC_27129775_Chip-Seq_CORNEA_Mouse0.85381972
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84356597
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83691310
99CJUN_26792858_Chip-Seq_BT549_Human0.83503590
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81975551
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81920398
102PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81838857
103* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81151556
104GF1_26923725_Chip-Seq_HPCs_Mouse0.81150821
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80679067
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.79796188
107CBX2_27304074_Chip-Seq_ESCs_Mouse0.79218462
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78460381
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78200558
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77935644
111* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77124773
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76488412
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75488950
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.75482973
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75277294
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75277294
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74793737
118EZH2_27294783_Chip-Seq_ESCs_Mouse0.74236324
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74058140
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72870578
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.72454165
122OCT4_20526341_ChIP-Seq_ESCs_Human0.71782327
123HTT_18923047_ChIP-ChIP_STHdh_Human0.71731904
124MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71478692
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71300026
126JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70710116
127CRX_20693478_ChIP-Seq_RETINA_Mouse0.69942481
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69801152
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69581553
130SMAD4_21799915_ChIP-Seq_A2780_Human0.67774620
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.66942884
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66676170
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.65650606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.78780955
2MP0002837_dystrophic_cardiac_calcinosis6.73526846
3MP0004036_abnormal_muscle_relaxation4.76028829
4MP0004215_abnormal_myocardial_fiber4.72330770
5MP0000751_myopathy4.60167034
6MP0003646_muscle_fatigue4.16826949
7MP0005330_cardiomyopathy4.13871362
8MP0000749_muscle_degeneration3.73028491
9MP0002972_abnormal_cardiac_muscle3.53535621
10MP0008775_abnormal_heart_ventricle3.36517323
11MP0003137_abnormal_impulse_conducting3.17167147
12MP0004087_abnormal_muscle_fiber3.09216377
13MP0010630_abnormal_cardiac_muscle2.87551730
14MP0005620_abnormal_muscle_contractility2.84493046
15MP0006138_congestive_heart_failure2.80846274
16MP0001544_abnormal_cardiovascular_syste2.79059224
17MP0005385_cardiovascular_system_phenoty2.79059224
18MP0003828_pulmonary_edema2.69260996
19MP0000750_abnormal_muscle_regeneration2.44746532
20MP0002106_abnormal_muscle_physiology2.38032302
21MP0004085_abnormal_heartbeat2.33022658
22MP0004145_abnormal_muscle_electrophysio2.19615726
23MP0002269_muscular_atrophy2.05737913
24MP0003221_abnormal_cardiomyocyte_apopto2.03700012
25MP0002127_abnormal_cardiovascular_syste2.02675863
26MP0004484_altered_response_of2.00161658
27MP0005369_muscle_phenotype1.89136083
28MP0003567_abnormal_fetal_cardiomyocyte1.87372049
29MP0003950_abnormal_plasma_membrane1.85265183
30MP0004510_myositis1.81594049
31MP0004233_abnormal_muscle_weight1.77030544
32MP0000759_abnormal_skeletal_muscle1.71036216
33MP0000747_muscle_weakness1.70806081
34MP0004130_abnormal_muscle_cell1.66132746
35MP0005451_abnormal_body_composition1.63624854
36MP0003279_aneurysm1.47274005
37MP0000266_abnormal_heart_morphology1.28656812
38MP0002234_abnormal_pharynx_morphology1.28619813
39MP0010368_abnormal_lymphatic_system1.27937963
40MP0006036_abnormal_mitochondrial_physio1.25685140
41MP0003122_maternal_imprinting1.20253142
42MP0004272_abnormal_basement_membrane1.18938711
43MP0005623_abnormal_meninges_morphology1.13094936
44MP0003566_abnormal_cell_adhesion1.10552059
45MP0002332_abnormal_exercise_endurance1.06817902
46MP0003705_abnormal_hypodermis_morpholog0.94168705
47MP0005666_abnormal_adipose_tissue0.93164796
48MP0002128_abnormal_blood_circulation0.92727422
49MP0001661_extended_life_span0.89995953
50MP0000343_altered_response_to0.86819259
51MP0000767_abnormal_smooth_muscle0.84909013
52MP0005165_increased_susceptibility_to0.80864957
53MP0006035_abnormal_mitochondrial_morpho0.80090500
54MP0009384_cardiac_valve_regurgitation0.79665879
55MP0005670_abnormal_white_adipose0.75679150
56MP0000733_abnormal_muscle_development0.72548346
57MP0003123_paternal_imprinting0.72117032
58MP0000230_abnormal_systemic_arterial0.69683406
59MP0002925_abnormal_cardiovascular_devel0.69594375
60MP0009780_abnormal_chondrocyte_physiolo0.68905348
61MP0005377_hearing/vestibular/ear_phenot0.67211667
62MP0003878_abnormal_ear_physiology0.67211667
63MP0002088_abnormal_embryonic_growth/wei0.65315909
64MP0003984_embryonic_growth_retardation0.64551137
65MP0001879_abnormal_lymphatic_vessel0.63880816
66MP0008438_abnormal_cutaneous_collagen0.63809738
67MP0005375_adipose_tissue_phenotype0.61885502
68MP0004270_analgesia0.60857397
69MP0005266_abnormal_metabolism0.60786653
70MP0001784_abnormal_fluid_regulation0.58372827
71MP0002108_abnormal_muscle_morphology0.58192775
72MP0003045_fibrosis0.56079787
73MP0003806_abnormal_nucleotide_metabolis0.52750401
74MP0004185_abnormal_adipocyte_glucose0.52652380
75MP0001614_abnormal_blood_vessel0.51144539
76MP0003121_genomic_imprinting0.50068718
77MP0008569_lethality_at_weaning0.42632650
78MP0005380_embryogenesis_phenotype0.42252250
79MP0001672_abnormal_embryogenesis/_devel0.42252250
80MP0000013_abnormal_adipose_tissue0.41507425
81MP0005275_abnormal_skin_tensile0.40058284
82MP0002909_abnormal_adrenal_gland0.39406236
83MP0005187_abnormal_penis_morphology0.38380792
84MP0001299_abnormal_eye_distance/0.38282556
85MP0002822_catalepsy0.37384879
86MP0002638_abnormal_pupillary_reflex0.36013659
87MP0003948_abnormal_gas_homeostasis0.35719749
88MP0005595_abnormal_vascular_smooth0.34162061
89MP0000003_abnormal_adipose_tissue0.33887440
90MP0003385_abnormal_body_wall0.32474363
91MP0009672_abnormal_birth_weight0.31379712
92MP0005319_abnormal_enzyme/_coenzyme0.30810982
93MP0002133_abnormal_respiratory_system0.29689413
94MP0005388_respiratory_system_phenotype0.29689413
95MP0005167_abnormal_blood-brain_barrier0.29249736
96MP0003115_abnormal_respiratory_system0.29116785
97MP0005376_homeostasis/metabolism_phenot0.28456488
98MP0001958_emphysema0.28375988
99MP0005584_abnormal_enzyme/coenzyme_acti0.27181371
100MP0001727_abnormal_embryo_implantation0.26276831
101MP0001175_abnormal_lung_morphology0.25764762
102MP0005535_abnormal_body_temperature0.25266131
103MP0000762_abnormal_tongue_morphology0.25227897
104MP0005334_abnormal_fat_pad0.24944913
105MP0003935_abnormal_craniofacial_develop0.24339717
106MP0003656_abnormal_erythrocyte_physiolo0.23429413
107MP0001697_abnormal_embryo_size0.22851552
108MP0005386_behavior/neurological_phenoty0.22704422
109MP0004924_abnormal_behavior0.22704422
110MP0004147_increased_porphyrin_level0.22601736
111MP0004197_abnormal_fetal_growth/weight/0.22594859
112MP0000428_abnormal_craniofacial_morphol0.22517183
113MP0000249_abnormal_blood_vessel0.22444373
114MP0002078_abnormal_glucose_homeostasis0.22412067
115MP0001984_abnormal_olfaction0.21411135
116MP0008961_abnormal_basal_metabolism0.21071743
117MP0002971_abnormal_brown_adipose0.20826513
118MP0003941_abnormal_skin_development0.20659826
119MP0002086_abnormal_extraembryonic_tissu0.19347028
120MP0000372_irregular_coat_pigmentation0.18850250
121MP0003879_abnormal_hair_cell0.18702082
122MP0008004_abnormal_stomach_pH0.18563828
123MP0005332_abnormal_amino_acid0.18297334
124MP0009115_abnormal_fat_cell0.18159573
125MP0008874_decreased_physiological_sensi0.16607510
126MP0004043_abnormal_pH_regulation0.16216492
127MP0005166_decreased_susceptibility_to0.16180395
128MP0002896_abnormal_bone_mineralization0.15419544
129MP0000579_abnormal_nail_morphology0.15204348
130MP0005452_abnormal_adipose_tissue0.14809468

Predicted human phenotypes

RankGene SetZ-score
1* Sudden death (HP:0001699)8.82197786
2Ventricular tachycardia (HP:0004756)7.34653589
3Atrial fibrillation (HP:0005110)6.67629013
4Primary atrial arrhythmia (HP:0001692)6.24208607
5Calf muscle hypertrophy (HP:0008981)6.23733962
6Exercise-induced muscle cramps (HP:0003710)6.10129667
7Supraventricular tachycardia (HP:0004755)6.03988937
8Supraventricular arrhythmia (HP:0005115)5.95763801
9* Lipoatrophy (HP:0100578)5.93424874
10Muscle fiber splitting (HP:0003555)5.92050572
11Muscle hypertrophy of the lower extremities (HP:0008968)5.66075436
12* Subaortic stenosis (HP:0001682)5.65439989
13* Abnormality of the left ventricular outflow tract (HP:0011103)5.65439989
14Exercise-induced myalgia (HP:0003738)5.56722210
15Syncope (HP:0001279)5.30815861
16Right ventricular cardiomyopathy (HP:0011663)5.20813045
17Hyporeflexia of lower limbs (HP:0002600)5.16332202
18Prolonged QT interval (HP:0001657)5.13459520
19* Abnormality of the calf musculature (HP:0001430)5.00783015
20* Dilated cardiomyopathy (HP:0001644)4.73743803
21Palpitations (HP:0001962)4.61276078
22Ventricular fibrillation (HP:0001663)4.60435354
23* Ventricular arrhythmia (HP:0004308)4.48996599
24Myopathic facies (HP:0002058)4.37492815
25Distal arthrogryposis (HP:0005684)4.25353851
26Bundle branch block (HP:0011710)4.18174155
27* EMG: myopathic abnormalities (HP:0003458)4.05413145
28Myoglobinuria (HP:0002913)4.00845440
29Abnormal EKG (HP:0003115)3.79665171
30Atrioventricular block (HP:0001678)3.72804668
31Heart block (HP:0012722)3.64921101
32Increased connective tissue (HP:0009025)3.58250684
33Round ear (HP:0100830)3.56862444
34* Centrally nucleated skeletal muscle fibers (HP:0003687)3.55192124
35Abnormal atrioventricular conduction (HP:0005150)3.43673276
36Left ventricular hypertrophy (HP:0001712)3.34113668
37Myotonia (HP:0002486)3.30981083
38* Asymmetric septal hypertrophy (HP:0001670)3.27419313
39Ulnar deviation of the wrist (HP:0003049)3.23981886
40Muscle fiber inclusion bodies (HP:0100299)3.15612350
41Frequent falls (HP:0002359)3.13802961
42Rhabdomyolysis (HP:0003201)3.09603206
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.06037412
44Congenital malformation of the right heart (HP:0011723)3.01044320
45Double outlet right ventricle (HP:0001719)3.01044320
46Difficulty running (HP:0009046)2.89421649
47* Palmoplantar keratoderma (HP:0000982)2.85500763
48Difficulty climbing stairs (HP:0003551)2.79347928
49Calcaneovalgus deformity (HP:0001848)2.74840639
50* Type 1 muscle fiber predominance (HP:0003803)2.60118257
51Bulbar palsy (HP:0001283)2.54961827
52Absent phalangeal crease (HP:0006109)2.53191180
53Hypoplastic left heart (HP:0004383)2.44565157
54Abnormal mitochondria in muscle tissue (HP:0008316)2.41313991
55Deformed tarsal bones (HP:0008119)2.41059881
56Nemaline bodies (HP:0003798)2.38957586
57Conjunctival hamartoma (HP:0100780)2.36534265
58Pulmonary artery stenosis (HP:0004415)2.36093659
59* Neck muscle weakness (HP:0000467)2.36056826
60Patent foramen ovale (HP:0001655)2.34720885
61Acute necrotizing encephalopathy (HP:0006965)2.33638455
62Hepatic necrosis (HP:0002605)2.31479610
63Muscle stiffness (HP:0003552)2.29119800
64Distal lower limb muscle weakness (HP:0009053)2.27329290
65Neoplasm of the adrenal gland (HP:0100631)2.27118574
66Limb-girdle muscle atrophy (HP:0003797)2.26113451
67Increased variability in muscle fiber diameter (HP:0003557)2.24132862
68Malignant hyperthermia (HP:0002047)2.23947044
69Lower limb amyotrophy (HP:0007210)2.23595825
70* Sudden cardiac death (HP:0001645)2.23170949
71Weak cry (HP:0001612)2.23068480
72Proximal amyotrophy (HP:0007126)2.22949158
73Lymphangioma (HP:0100764)2.21239072
74Rimmed vacuoles (HP:0003805)2.18238682
75Abnormality of skeletal muscle fiber size (HP:0012084)2.15009942
76Ketoacidosis (HP:0001993)2.13185459
77Hip contracture (HP:0003273)2.09695640
78Areflexia of lower limbs (HP:0002522)2.09342988
79Progressive muscle weakness (HP:0003323)2.08253095
80Pheochromocytoma (HP:0002666)2.07046980
81* Congestive heart failure (HP:0001635)2.06135902
82Abnormal finger flexion creases (HP:0006143)2.04858153
83Hepatocellular necrosis (HP:0001404)2.01828459
84Foot dorsiflexor weakness (HP:0009027)2.01765650
85* Scapular winging (HP:0003691)2.00978706
86Hypoglycemic coma (HP:0001325)2.00097120
87Distal lower limb amyotrophy (HP:0008944)1.97209030
88Acute encephalopathy (HP:0006846)1.93600653
89Mitochondrial inheritance (HP:0001427)1.91901444
90Preauricular pit (HP:0004467)1.91738862
91Periauricular skin pits (HP:0100277)1.91738862
92Exercise intolerance (HP:0003546)1.91548189
93* Abnormality of the foot musculature (HP:0001436)1.91429809
94Multiple enchondromatosis (HP:0005701)1.90495811
95Hamartoma of the eye (HP:0010568)1.89405273
96Steppage gait (HP:0003376)1.88897186
97Hypoplastic heart (HP:0001961)1.88566098
98Respiratory insufficiency due to muscle weakness (HP:0002747)1.86872169
99Slender build (HP:0001533)1.86260724
100Progressive macrocephaly (HP:0004481)1.85434805
101Increased intramyocellular lipid droplets (HP:0012240)1.84539541
102Dysmetric saccades (HP:0000641)1.84143142
103Increased CSF lactate (HP:0002490)1.83529395
104Gowers sign (HP:0003391)1.81712038
105Neuroendocrine neoplasm (HP:0100634)1.79702766
106Fatigable weakness (HP:0003473)1.79515441
107Abnormality of the neuromuscular junction (HP:0003398)1.79515441
108* Ragged-red muscle fibers (HP:0003200)1.78981218
109Increased muscle lipid content (HP:0009058)1.77628729
110* Mildly elevated creatine phosphokinase (HP:0008180)1.76741130
111Muscular dystrophy (HP:0003560)1.75457253
112Fetal akinesia sequence (HP:0001989)1.73580166
113Hyperkalemia (HP:0002153)1.72360326
114Cerebral edema (HP:0002181)1.71894312
115* Generalized muscle weakness (HP:0003324)1.70747994
116Testicular atrophy (HP:0000029)1.70690147
117Dicarboxylic aciduria (HP:0003215)1.70305632
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70305632
119Bradycardia (HP:0001662)1.68855676
120* EMG: neuropathic changes (HP:0003445)1.68225511
121* Abnormality of the shoulder girdle musculature (HP:0001435)1.67768723
122Pancreatic islet-cell hyperplasia (HP:0004510)1.66452332
123Diaphragmatic weakness (HP:0009113)1.65438740
124Spinal rigidity (HP:0003306)1.65353922
125Neoplasm of head and neck (HP:0012288)1.64818136
126Limb-girdle muscle weakness (HP:0003325)1.64138373
127* Waddling gait (HP:0002515)1.60898356
128Facial diplegia (HP:0001349)1.52173886
129Abnormality of the calcaneus (HP:0008364)1.48922388
130Increased serum pyruvate (HP:0003542)1.47838928
131Limited hip movement (HP:0008800)1.46619698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.44536485
2MYLK4.55791326
3PKN24.43127774
4TTN4.29096582
5DMPK3.59165931
6LMTK23.54097991
7PHKG13.11794620
8PHKG23.11794620
9STK243.11365787
10TRIB32.89142018
11PDK42.45477657
12PDK32.45477657
13PIK3CA2.43833663
14TIE12.34141320
15NEK12.32066318
16CDC42BPA1.97932589
17MUSK1.97282583
18ILK1.81409814
19BCKDK1.47718858
20ZAK1.41391397
21DAPK31.38601765
22FLT31.37440414
23ROCK11.37390354
24MARK11.36874734
25PDK21.30827857
26PRKD11.27474178
27STK38L1.25827997
28PAK31.25450453
29MAP3K51.14484340
30WNK41.12647283
31RIPK11.08362628
32PTK2B1.04131169
33TRPM71.03626293
34MAPK121.02864389
35CAMK2D1.01848753
36MAP3K71.01257269
37STK40.99428192
38MAPKAPK30.94679103
39PINK10.89970907
40MAP3K100.85592921
41MAP3K60.81737977
42EEF2K0.79873866
43PRKAA10.73932065
44STK380.72060295
45MAP3K30.71914156
46PRKAA20.71397795
47ROCK20.70487897
48MAP2K40.69573398
49INSRR0.69157183
50PDGFRA0.66096304
51KDR0.65180161
52PKN10.65070109
53MAPK40.61911710
54CAMK10.60128750
55LIMK10.58605212
56ICK0.58378821
57MAP2K30.57466234
58TGFBR20.56614116
59EPHA30.56500958
60CAMK2B0.55819573
61STK390.55699165
62WNK10.55095481
63PTK60.54433209
64CAMK40.53954504
65DYRK1B0.53241875
66SIK10.52314795
67CAMK2A0.51478798
68RPS6KL10.51236226
69RPS6KC10.51236226
70MOS0.50179989
71MAP2K10.48520251
72PRKACB0.48268878
73PRKD30.47025709
74MAP2K60.45169408
75AKT20.43800171
76KSR20.43524204
77GRK70.43165989
78UHMK10.43165180
79PRKCE0.42419299
80ERBB30.42205131
81CCNB10.42131845
82RPS6KA60.41942061
83EPHB20.40998789
84SGK30.36882105
85EPHB10.34785593
86PRKACA0.34274485
87PAK20.34188943
88PIK3CG0.33214290
89PRKG20.32826239
90PRKACG0.31477245
91LRRK20.29627762
92RPS6KA30.29614878
93LATS20.29443069
94MTOR0.28854357
95SGK20.26237329
96MAPK100.23729703
97MAP3K130.22517840
98PDK10.22495581
99PDPK10.21563539
100FGFR10.21327505
101RET0.21064282
102PRPF4B0.21003552
103TESK10.20528023
104PRKG10.19657071
105RPS6KA20.19044454
106TGFBR10.18846684
107PRKCH0.18630264
108LATS10.18427132
109CDK40.18352641
110FER0.18349559
111CAMK2G0.18142481
112MARK20.17381669
113MARK30.17219416
114SGK10.16860106
115MAPK110.16783487
116ZAP700.16598990
117NLK0.16246301
118MAPKAPK20.16183259
119NME10.15310748
120MAP3K10.14610014
121RPS6KA10.14339137
122TBK10.13635213
123RPS6KB20.11683976
124STK110.11659158
125SGK2230.11484688
126SGK4940.11484688
127STK30.11447724
128NEK90.11159455
129PRKCQ0.10998817
130MAPK70.10670883
131ITK0.10475408

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.78706722
2* Cardiac muscle contraction_Homo sapiens_hsa042605.04419502
3* Dilated cardiomyopathy_Homo sapiens_hsa054144.48685556
4* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.43587514
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.32488577
6Parkinsons disease_Homo sapiens_hsa050123.02550118
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97488371
8Oxidative phosphorylation_Homo sapiens_hsa001902.79981801
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.78922087
10Propanoate metabolism_Homo sapiens_hsa006402.39419391
11Carbon metabolism_Homo sapiens_hsa012002.37689225
12* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.28706155
13Fatty acid degradation_Homo sapiens_hsa000712.27983469
14Alzheimers disease_Homo sapiens_hsa050102.14359164
15Huntingtons disease_Homo sapiens_hsa050161.88957443
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88248767
17Fatty acid metabolism_Homo sapiens_hsa012121.63806972
18Pyruvate metabolism_Homo sapiens_hsa006201.57706236
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50044078
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49798806
21* Viral myocarditis_Homo sapiens_hsa054161.38293869
22Biosynthesis of amino acids_Homo sapiens_hsa012301.37440379
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34402541
24Glucagon signaling pathway_Homo sapiens_hsa049221.21670218
25* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19418122
26Starch and sucrose metabolism_Homo sapiens_hsa005001.10582815
27Insulin resistance_Homo sapiens_hsa049311.09753057
28Focal adhesion_Homo sapiens_hsa045101.08554975
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05406839
30HIF-1 signaling pathway_Homo sapiens_hsa040660.96838172
31Butanoate metabolism_Homo sapiens_hsa006500.93472606
32* Tight junction_Homo sapiens_hsa045300.90966321
33Insulin signaling pathway_Homo sapiens_hsa049100.88636609
34Fatty acid elongation_Homo sapiens_hsa000620.86685785
35Adipocytokine signaling pathway_Homo sapiens_hsa049200.83750512
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83376289
37Lysine degradation_Homo sapiens_hsa003100.81915809
38ECM-receptor interaction_Homo sapiens_hsa045120.81751282
39PPAR signaling pathway_Homo sapiens_hsa033200.77525102
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.76231017
41Galactose metabolism_Homo sapiens_hsa000520.74884640
42Calcium signaling pathway_Homo sapiens_hsa040200.74248468
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.73507544
44Oxytocin signaling pathway_Homo sapiens_hsa049210.73348020
45AMPK signaling pathway_Homo sapiens_hsa041520.66010967
46Adherens junction_Homo sapiens_hsa045200.65044316
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62647430
48Amoebiasis_Homo sapiens_hsa051460.61777841
49Arginine biosynthesis_Homo sapiens_hsa002200.61622732
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60572187
51Type II diabetes mellitus_Homo sapiens_hsa049300.60157301
52Fructose and mannose metabolism_Homo sapiens_hsa000510.56084830
53Tryptophan metabolism_Homo sapiens_hsa003800.55480695
54Pancreatic secretion_Homo sapiens_hsa049720.50508228
55Phenylalanine metabolism_Homo sapiens_hsa003600.50335813
56Long-term potentiation_Homo sapiens_hsa047200.50209758
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49693586
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49670199
59Renin secretion_Homo sapiens_hsa049240.48861166
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48823397
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.47867705
62cAMP signaling pathway_Homo sapiens_hsa040240.47678801
63Insulin secretion_Homo sapiens_hsa049110.46337167
64Arginine and proline metabolism_Homo sapiens_hsa003300.43898429
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43530663
66Salivary secretion_Homo sapiens_hsa049700.41919164
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41688186
68Gastric acid secretion_Homo sapiens_hsa049710.40543162
69Proteoglycans in cancer_Homo sapiens_hsa052050.39873165
70beta-Alanine metabolism_Homo sapiens_hsa004100.38889544
71Circadian entrainment_Homo sapiens_hsa047130.38619988
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38190610
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34491874
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33624639
75Amphetamine addiction_Homo sapiens_hsa050310.32096834
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30771601
77FoxO signaling pathway_Homo sapiens_hsa040680.28845062
78Fatty acid biosynthesis_Homo sapiens_hsa000610.26540244
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25822192
80MAPK signaling pathway_Homo sapiens_hsa040100.25068872
81Protein digestion and absorption_Homo sapiens_hsa049740.24309980
82Regulation of autophagy_Homo sapiens_hsa041400.24135065
83Platelet activation_Homo sapiens_hsa046110.24133525
84Ovarian steroidogenesis_Homo sapiens_hsa049130.23771766
85Small cell lung cancer_Homo sapiens_hsa052220.23327189
86Nitrogen metabolism_Homo sapiens_hsa009100.21645092
87GABAergic synapse_Homo sapiens_hsa047270.21425871
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20932933
89Olfactory transduction_Homo sapiens_hsa047400.19383352
90GnRH signaling pathway_Homo sapiens_hsa049120.18638637
91Sulfur relay system_Homo sapiens_hsa041220.18364429
92mTOR signaling pathway_Homo sapiens_hsa041500.17986162
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.17887814
94Circadian rhythm_Homo sapiens_hsa047100.16585863
95Renal cell carcinoma_Homo sapiens_hsa052110.16216258
96Gap junction_Homo sapiens_hsa045400.14874665
97Melanogenesis_Homo sapiens_hsa049160.14727005
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14682546
99Prion diseases_Homo sapiens_hsa050200.14659477
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14507252
101Bile secretion_Homo sapiens_hsa049760.13364648
102Metabolic pathways_Homo sapiens_hsa011000.12446567
103VEGF signaling pathway_Homo sapiens_hsa043700.12389208
104Peroxisome_Homo sapiens_hsa041460.12296218
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12197277
106Pentose phosphate pathway_Homo sapiens_hsa000300.11176858
107Notch signaling pathway_Homo sapiens_hsa043300.11034492
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.10866626
109Tyrosine metabolism_Homo sapiens_hsa003500.10250421
110Cholinergic synapse_Homo sapiens_hsa047250.09619954
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08221521
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08132447
113Morphine addiction_Homo sapiens_hsa050320.07825062
114Dopaminergic synapse_Homo sapiens_hsa047280.06543358
115Taste transduction_Homo sapiens_hsa047420.06393233
116Estrogen signaling pathway_Homo sapiens_hsa049150.06305119
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04602106
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03374180

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