MYH7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.13630681
2cardiac myofibril assembly (GO:0055003)8.92133478
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.60228329
4negative regulation of potassium ion transmembrane transport (GO:1901380)7.88646914
5myofibril assembly (GO:0030239)7.85411449
6cardiac muscle cell development (GO:0055013)6.94268430
7cardiac muscle contraction (GO:0060048)6.82512747
8actin-myosin filament sliding (GO:0033275)6.76150771
9muscle filament sliding (GO:0030049)6.76150771
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.56643777
11cardiac cell development (GO:0055006)6.51546371
12adult heart development (GO:0007512)6.38697692
13ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.34006103
14cardiac muscle tissue morphogenesis (GO:0055008)6.17760804
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.11533711
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.01284962
17plasma membrane repair (GO:0001778)5.95207176
18ventricular cardiac muscle cell action potential (GO:0086005)5.87214544
19actomyosin structure organization (GO:0031032)5.81494104
20regulation of actin filament-based movement (GO:1903115)5.80672365
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.77115136
22acrosome reaction (GO:0007340)5.74219834
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.71521298
24cardiac muscle hypertrophy (GO:0003300)5.64203363
25actin-mediated cell contraction (GO:0070252)5.53035729
26tricarboxylic acid cycle (GO:0006099)5.49612774
27muscle tissue morphogenesis (GO:0060415)5.46278839
28sperm motility (GO:0030317)5.45189271
29bundle of His cell to Purkinje myocyte communication (GO:0086069)5.45121363
30striated muscle hypertrophy (GO:0014897)5.31702961
31heart trabecula formation (GO:0060347)5.31451892
32regulation of relaxation of muscle (GO:1901077)5.28572778
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.22672145
34regulation of the force of heart contraction (GO:0002026)5.22540931
35regulation of sarcomere organization (GO:0060297)5.21780297
36striated muscle contraction (GO:0006941)5.18767590
37carnitine shuttle (GO:0006853)5.10143935
38regulation of skeletal muscle contraction (GO:0014819)4.88327545
39skeletal muscle contraction (GO:0003009)4.88179663
40regulation of striated muscle contraction (GO:0006942)4.82169503
41sperm capacitation (GO:0048240)4.80757015
42cell communication involved in cardiac conduction (GO:0086065)4.74694751
43muscle hypertrophy (GO:0014896)4.63742311
44regulation of membrane repolarization (GO:0060306)4.60296250
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.57899162
46cell communication by electrical coupling (GO:0010644)4.49956491
47fusion of sperm to egg plasma membrane (GO:0007342)4.49688824
48heart process (GO:0003015)4.43595684
49heart contraction (GO:0060047)4.43595684
50response to pheromone (GO:0019236)4.39363222
51negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.36089474
52fatty acid transmembrane transport (GO:1902001)4.29460082
53regulation of cell communication by electrical coupling (GO:0010649)4.29376540
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.28050822
55actin filament-based movement (GO:0030048)4.24024177
56regulation of cardioblast differentiation (GO:0051890)4.23096217
57regulation of heart rate (GO:0002027)4.22782234
58response to inactivity (GO:0014854)4.19863348
59negative regulation of potassium ion transport (GO:0043267)4.19841640
60regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.19481791
61sarcoplasmic reticulum calcium ion transport (GO:0070296)4.17630824
62cardiac muscle cell action potential involved in contraction (GO:0086002)4.16272681
63cardiac muscle cell action potential (GO:0086001)4.12821879
64regulation of cardiac muscle contraction (GO:0055117)4.06819548
65negative regulation of striated muscle cell apoptotic process (GO:0010664)4.06167715
66cellular ketone body metabolic process (GO:0046950)3.99618591
67cardiac muscle hypertrophy in response to stress (GO:0014898)3.96328321
68muscle hypertrophy in response to stress (GO:0003299)3.96328321
69cardiac muscle adaptation (GO:0014887)3.96328321
70ventricular cardiac muscle cell development (GO:0055015)3.95594738
71regulation of heart contraction (GO:0008016)3.93525549
72regulation of cardiac muscle cell contraction (GO:0086004)3.93293847
73regulation of acyl-CoA biosynthetic process (GO:0050812)3.81638666
74negative regulation of protein localization to cell surface (GO:2000009)3.80324714
75protein polyglutamylation (GO:0018095)3.74683490
76striated muscle cell development (GO:0055002)3.72812401
77regulation of ATPase activity (GO:0043462)3.72410216
78regulation of ATP catabolic process (GO:1903289)3.72410216
79carnitine transmembrane transport (GO:1902603)3.68662667
80spermatid development (GO:0007286)3.67280356
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.65865828
82muscle system process (GO:0003012)3.64721015
83calcium ion-dependent exocytosis (GO:0017156)3.61984042
84oxygen transport (GO:0015671)3.61978556
85oxidative phosphorylation (GO:0006119)3.61677938
86cardiac conduction (GO:0061337)3.58387401
87response to muscle activity (GO:0014850)3.56477648
88relaxation of cardiac muscle (GO:0055119)3.54505923
89creatine metabolic process (GO:0006600)3.54240528
90ketone body metabolic process (GO:1902224)3.51489260
91multicellular organism reproduction (GO:0032504)3.50613196
92trabecula formation (GO:0060343)3.50285651
93regulation of striated muscle cell apoptotic process (GO:0010662)3.49684697
94regulation of coenzyme metabolic process (GO:0051196)3.48828264
95regulation of cofactor metabolic process (GO:0051193)3.48828264
96plasma membrane fusion (GO:0045026)3.47835320
97response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.47012125
98regulation of heart rate by cardiac conduction (GO:0086091)3.42889883
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.39016816
100positive regulation of action potential (GO:0045760)3.34758040
101striated muscle adaptation (GO:0014888)3.33131273
102carnitine transport (GO:0015879)3.32095934
103amino-acid betaine transport (GO:0015838)3.32095934
104negative regulation of inclusion body assembly (GO:0090084)3.31775558
105positive regulation of heart contraction (GO:0045823)3.30819187
106negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27764748
107establishment of protein localization to Golgi (GO:0072600)3.27321931
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26530503
109protein targeting to Golgi (GO:0000042)3.25909543
110potassium ion export (GO:0071435)3.25082280
111muscle contraction (GO:0006936)3.25080969
112cardiac chamber formation (GO:0003207)3.23672428
113muscle cell development (GO:0055001)3.21331649
114response to caffeine (GO:0031000)3.20822278
115membrane depolarization during action potential (GO:0086010)3.20660699
116transcription from mitochondrial promoter (GO:0006390)3.19289733
117positive regulation of heart rate (GO:0010460)3.18164133
118regulation of muscle contraction (GO:0006937)3.16750905
119positive regulation of cation channel activity (GO:2001259)3.13950159
120retrograde transport, vesicle recycling within Golgi (GO:0000301)3.13637086
121phosphatidylethanolamine biosynthetic process (GO:0006646)3.09643276
122ATP synthesis coupled proton transport (GO:0015986)3.09446392
123energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09446392
1242-oxoglutarate metabolic process (GO:0006103)3.08771526
125regulation of calcium ion transmembrane transport (GO:1903169)3.08049786
126regulation of calcium ion transmembrane transporter activity (GO:1901019)3.08049786
127regulation of sequestering of triglyceride (GO:0010889)3.06455890
128mitochondrial fusion (GO:0008053)3.04651693
129regulation of cardiac muscle cell apoptotic process (GO:0010665)3.04071780
130reproduction (GO:0000003)3.03308972
131membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.02791320
132cardiac ventricle formation (GO:0003211)2.98362205
133single strand break repair (GO:0000012)2.98153828
134detection of calcium ion (GO:0005513)2.96014502
135phosphatidylethanolamine metabolic process (GO:0046337)2.93240993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16056432
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.98445461
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40508204
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.82171317
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.40681510
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.33206005
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.33206005
8ZNF263_19887448_ChIP-Seq_K562_Human3.02937844
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.96511931
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70424522
11NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.47905099
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45081715
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.39204552
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32172739
15* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.26986532
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26223570
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.24132310
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.18093287
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17347263
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11679661
21GATA4_21415370_ChIP-Seq_HL-1_Mouse2.00672221
22LXR_22292898_ChIP-Seq_THP-1_Human2.00355827
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97752737
24VDR_22108803_ChIP-Seq_LS180_Human1.96595379
25CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.94516441
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92174619
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88442949
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87290627
29GBX2_23144817_ChIP-Seq_PC3_Human1.85557908
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85424501
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83382707
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80149872
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75327705
34KDM2B_26808549_Chip-Seq_DND41_Human1.75026348
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.71120571
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69500480
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65269399
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.63901937
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62955400
40RACK7_27058665_Chip-Seq_MCF-7_Human1.62078923
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60836756
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60836756
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60836756
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.59910722
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53702516
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53702516
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.51491134
48SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.50719048
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49755459
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.48790994
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48284727
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46816896
53CTCF_27219007_Chip-Seq_Bcells_Human1.46230074
54ZNF274_21170338_ChIP-Seq_K562_Hela1.45203151
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43476836
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.43105423
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43020206
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.42378615
59CBP_20019798_ChIP-Seq_JUKART_Human1.41396132
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41396132
61ER_23166858_ChIP-Seq_MCF-7_Human1.41343812
62KDM2B_26808549_Chip-Seq_K562_Human1.40458224
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37448463
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36625661
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35495321
66AR_21572438_ChIP-Seq_LNCaP_Human1.35135610
67OCT4_20526341_ChIP-Seq_ESCs_Human1.35034252
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34254982
69TP63_22573176_ChIP-Seq_HFKS_Human1.30892807
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30421970
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.29714359
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29236057
73POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28019969
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27639030
75* SMAD4_21799915_ChIP-Seq_A2780_Human1.27567895
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26852777
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25705482
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24801137
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24483811
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24177831
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22249473
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22159037
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21084716
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.20642392
85NANOG_20526341_ChIP-Seq_ESCs_Human1.20414799
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.20145138
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20111558
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19821291
89NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19124929
90* P68_20966046_ChIP-Seq_HELA_Human1.18758225
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18097757
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17168660
93FUS_26573619_Chip-Seq_HEK293_Human1.16898774
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.16891153
95SMAD4_21741376_ChIP-Seq_HESCs_Human1.15053943
96AR_25329375_ChIP-Seq_VCAP_Human1.14779076
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14379993
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.14328784
99P300_19829295_ChIP-Seq_ESCs_Human1.13969297
100ATF3_27146783_Chip-Seq_COLON_Human1.13867271
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13520301
102* TP53_23651856_ChIP-Seq_MEFs_Mouse1.13301909
103TAF15_26573619_Chip-Seq_HEK293_Human1.12546249
104GATA1_19941826_ChIP-Seq_K562_Human1.11976498
105BCOR_27268052_Chip-Seq_Bcells_Human1.11863287
106TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11853465
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11665708
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11346375
109VDR_21846776_ChIP-Seq_THP-1_Human1.11320434
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11160457
111RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11160457
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10743982
113STAT3_23295773_ChIP-Seq_U87_Human1.10576187
114ERA_21632823_ChIP-Seq_H3396_Human1.10524325
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.10461689
116NANOG_19829295_ChIP-Seq_ESCs_Human1.10218270
117SOX2_19829295_ChIP-Seq_ESCs_Human1.10218270
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.10147098
119TCF4_23295773_ChIP-Seq_U87_Human1.10143088
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09953559
121WDR5_24793694_ChIP-Seq_LNCAP_Human1.09743626
122MYC_19829295_ChIP-Seq_ESCs_Human1.09640936
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08973155
124TET1_21451524_ChIP-Seq_MESCs_Mouse1.08666742
125ISL1_27105846_Chip-Seq_CPCs_Mouse1.08602865
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08602062
127REST_21632747_ChIP-Seq_MESCs_Mouse1.08443765
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07384044
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07262180
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07085118
131CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07031638
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06297862
133CREB1_26743006_Chip-Seq_LNCaP_Human1.05971608
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05672521
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05331763
136RAC3_21632823_ChIP-Seq_H3396_Human1.05293108
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04758187
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04439713
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04028873
140TRIM28_21343339_ChIP-Seq_HEK293_Human1.03749588
141ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02710499
142TCF7_22412390_ChIP-Seq_EML_Mouse1.02121289
143TAF2_19829295_ChIP-Seq_ESCs_Human1.01496269
144* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01334502
145ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01305610
146ERG_21242973_ChIP-ChIP_JURKAT_Human1.01106713
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00959835
148SOX2_21211035_ChIP-Seq_LN229_Gbm1.00572968
149TBL1_22424771_ChIP-Seq_293T_Human1.00418972
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00308795
151SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00162944
152CTCF_21964334_Chip-Seq_Bcells_Human0.99880555
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99745822
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99560425
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.99097564
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98739698
157* SMC4_20622854_ChIP-Seq_HELA_Human0.98657730
158SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98095613
159FLI1_27457419_Chip-Seq_LIVER_Mouse0.97738463
160E2F1_20622854_ChIP-Seq_HELA_Human0.97582042
161TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97295805
162PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96926786
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.96905463
164KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96637755
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95841281
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95458119
167TP53_20018659_ChIP-ChIP_R1E_Mouse0.95100573
168CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94585747
169OCT4_19829295_ChIP-Seq_ESCs_Human0.94505774
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94494230
171DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94124201
172TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93357972
173HNFA_21074721_ChIP-Seq_CACO-2_Human0.93338994
174NFYB_21822215_ChIP-Seq_K562_Human0.93010980
175PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92984652
176TP53_22127205_ChIP-Seq_IMR90_Human0.92724265
177DROSHA_22980978_ChIP-Seq_HELA_Human0.92467505
178IGF1R_20145208_ChIP-Seq_DFB_Human0.92248410
179SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91822659
180ETV1_20927104_ChIP-Seq_GIST48_Human0.91663774
181DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91522941
182SMAD3_21741376_ChIP-Seq_ESCs_Human0.91110732
183REST_18959480_ChIP-ChIP_MESCs_Mouse0.90774768
184P53_21459846_ChIP-Seq_SAOS-2_Human0.90650903
185RUNX2_22187159_ChIP-Seq_PCA_Human0.90575674
186GATA1_19941827_ChIP-Seq_MEL_Mouse0.90492219
187TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90453797
188SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90293379
189BCL6_27268052_Chip-Seq_Bcells_Human0.90125520
190DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88442511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.66060288
2MP0004084_abnormal_cardiac_muscle5.98157407
3MP0000751_myopathy4.96086840
4MP0003646_muscle_fatigue4.94547537
5MP0004215_abnormal_myocardial_fiber4.81503384
6MP0005330_cardiomyopathy4.12643155
7MP0004036_abnormal_muscle_relaxation4.05478212
8MP0005410_abnormal_fertilization3.85540563
9MP0000749_muscle_degeneration3.59414294
10MP0003137_abnormal_impulse_conducting3.37606936
11MP0008775_abnormal_heart_ventricle3.17971112
12MP0004087_abnormal_muscle_fiber3.09215025
13MP0002972_abnormal_cardiac_muscle3.08024942
14MP0010630_abnormal_cardiac_muscle2.84080850
15MP0003828_pulmonary_edema2.70718215
16MP0001544_abnormal_cardiovascular_syste2.58491974
17MP0005385_cardiovascular_system_phenoty2.58491974
18MP0000750_abnormal_muscle_regeneration2.53756469
19MP0005620_abnormal_muscle_contractility2.52787515
20MP0002269_muscular_atrophy2.49147001
21MP0006138_congestive_heart_failure2.44097812
22MP0002106_abnormal_muscle_physiology2.42223531
23MP0004233_abnormal_muscle_weight2.22572079
24MP0004085_abnormal_heartbeat2.18954378
25MP0004484_altered_response_of2.15507614
26MP0004130_abnormal_muscle_cell2.08306536
27MP0004145_abnormal_muscle_electrophysio1.99606848
28MP0002127_abnormal_cardiovascular_syste1.95341341
29MP0005369_muscle_phenotype1.95319786
30MP0000759_abnormal_skeletal_muscle1.88640423
31MP0003221_abnormal_cardiomyocyte_apopto1.87608290
32MP0000747_muscle_weakness1.77011036
33MP0003567_abnormal_fetal_cardiomyocyte1.68624815
34MP0004510_myositis1.67765965
35MP0002332_abnormal_exercise_endurance1.55957440
36MP0003950_abnormal_plasma_membrane1.53580480
37MP0006036_abnormal_mitochondrial_physio1.46337019
38MP0003698_abnormal_male_reproductive1.34621129
39MP0005666_abnormal_adipose_tissue1.29548795
40MP0005670_abnormal_white_adipose1.29333635
41MP0000266_abnormal_heart_morphology1.29041970
42MP0005623_abnormal_meninges_morphology1.17278691
43MP0003011_delayed_dark_adaptation1.06644254
44MP0005423_abnormal_somatic_nervous1.04747196
45MP0002822_catalepsy1.03243252
46MP0005165_increased_susceptibility_to1.02132130
47MP0000013_abnormal_adipose_tissue1.01735552
48MP0002234_abnormal_pharynx_morphology1.01550690
49MP0003279_aneurysm0.99825566
50MP0000343_altered_response_to0.99380754
51MP0001929_abnormal_gametogenesis0.96891323
52MP0010368_abnormal_lymphatic_system0.96597895
53MP0003705_abnormal_hypodermis_morpholog0.95928561
54MP0003566_abnormal_cell_adhesion0.95620143
55MP0004185_abnormal_adipocyte_glucose0.92695158
56MP0006035_abnormal_mitochondrial_morpho0.92064987
57MP0005266_abnormal_metabolism0.91432809
58MP0001486_abnormal_startle_reflex0.90035070
59MP0009745_abnormal_behavioral_response0.89370105
60MP0005551_abnormal_eye_electrophysiolog0.89161700
61MP0001485_abnormal_pinna_reflex0.87711549
62MP0002638_abnormal_pupillary_reflex0.85345560
63MP0005167_abnormal_blood-brain_barrier0.84744493
64MP0005375_adipose_tissue_phenotype0.83642215
65MP0002272_abnormal_nervous_system0.82076312
66MP0002735_abnormal_chemical_nociception0.81098503
67MP0002108_abnormal_muscle_morphology0.80727073
68MP0002128_abnormal_blood_circulation0.79992424
69MP0003984_embryonic_growth_retardation0.78519424
70MP0004270_analgesia0.78358605
71MP0008569_lethality_at_weaning0.78023940
72MP0002088_abnormal_embryonic_growth/wei0.76788437
73MP0001968_abnormal_touch/_nociception0.75855315
74MP0001348_abnormal_lacrimal_gland0.74697044
75MP0003879_abnormal_hair_cell0.72493396
76MP0005253_abnormal_eye_physiology0.69126353
77MP0002925_abnormal_cardiovascular_devel0.68864167
78MP0001984_abnormal_olfaction0.65419569
79MP0005380_embryogenesis_phenotype0.65113955
80MP0001672_abnormal_embryogenesis/_devel0.65113955
81MP0005451_abnormal_body_composition0.62775927
82MP0001501_abnormal_sleep_pattern0.61695310
83MP0004142_abnormal_muscle_tone0.61524681
84MP0004272_abnormal_basement_membrane0.61307437
85MP0003136_yellow_coat_color0.60500974
86MP0001986_abnormal_taste_sensitivity0.60327142
87MP0002067_abnormal_sensory_capabilities0.59342797
88MP0006276_abnormal_autonomic_nervous0.59308782
89MP0001784_abnormal_fluid_regulation0.57602082
90MP0002249_abnormal_larynx_morphology0.56450820
91MP0000767_abnormal_smooth_muscle0.56302473
92MP0001440_abnormal_grooming_behavior0.56206103
93MP0009278_abnormal_bone_marrow0.55812218
94MP0005083_abnormal_biliary_tract0.55672066
95MP0002734_abnormal_mechanical_nocicepti0.55570114
96MP0009780_abnormal_chondrocyte_physiolo0.54842425
97MP0002161_abnormal_fertility/fecundity0.54382828
98MP0001765_abnormal_ion_homeostasis0.53949137
99MP0000026_abnormal_inner_ear0.52711819
100MP0009046_muscle_twitch0.52587760
101MP0002572_abnormal_emotion/affect_behav0.52577919
102MP0003635_abnormal_synaptic_transmissio0.52467014
103MP0002064_seizures0.52418658
104MP0004924_abnormal_behavior0.51719025
105MP0005386_behavior/neurological_phenoty0.51719025
106MP0010030_abnormal_orbit_morphology0.51527458
107MP0006072_abnormal_retinal_apoptosis0.51422292
108MP0001661_extended_life_span0.51260800
109MP0001963_abnormal_hearing_physiology0.50454019
110MP0005171_absent_coat_pigmentation0.49553582
111MP0001970_abnormal_pain_threshold0.49365935
112MP0000733_abnormal_muscle_development0.49157912
113MP0002733_abnormal_thermal_nociception0.48822133
114MP0000230_abnormal_systemic_arterial0.47028218
115MP0002102_abnormal_ear_morphology0.46705736
116MP0004859_abnormal_synaptic_plasticity0.46513550
117MP0004133_heterotaxia0.46434749
118MP0005535_abnormal_body_temperature0.46142546
119MP0002909_abnormal_adrenal_gland0.45276991
120MP0000003_abnormal_adipose_tissue0.45188476
121MP0002086_abnormal_extraembryonic_tissu0.43940705
122MP0003119_abnormal_digestive_system0.43218893
123MP0003806_abnormal_nucleotide_metabolis0.43025773
124MP0001697_abnormal_embryo_size0.42959913
125MP0001614_abnormal_blood_vessel0.41871898
126MP0003935_abnormal_craniofacial_develop0.39454808
127MP0003283_abnormal_digestive_organ0.38454474
128MP0008057_abnormal_DNA_replication0.37985135
129MP0002971_abnormal_brown_adipose0.37257594
130MP0005319_abnormal_enzyme/_coenzyme0.37175020
131MP0008961_abnormal_basal_metabolism0.35535909
132MP0004197_abnormal_fetal_growth/weight/0.35244840
133MP0003941_abnormal_skin_development0.33818477
134MP0003878_abnormal_ear_physiology0.33559833
135MP0005377_hearing/vestibular/ear_phenot0.33559833
136MP0009115_abnormal_fat_cell0.32745604
137MP0002085_abnormal_embryonic_tissue0.31149500
138MP0002084_abnormal_developmental_patter0.30936730
139MP0002970_abnormal_white_adipose0.29554474
140MP0003948_abnormal_gas_homeostasis0.29380840
141MP0000762_abnormal_tongue_morphology0.28199323
142MP0003045_fibrosis0.27467769
143MP0008770_decreased_survivor_rate0.27173251
144MP0005187_abnormal_penis_morphology0.27013296
145MP0001727_abnormal_embryo_implantation0.26905683
146MP0002080_prenatal_lethality0.26609468
147MP0001879_abnormal_lymphatic_vessel0.26606265
148MP0002078_abnormal_glucose_homeostasis0.26194130
149MP0000579_abnormal_nail_morphology0.25560616

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.95041065
2Ventricular tachycardia (HP:0004756)7.31629706
3Atrial fibrillation (HP:0005110)6.38655864
4Muscle fiber inclusion bodies (HP:0100299)6.36743630
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.31002209
6Nemaline bodies (HP:0003798)6.27400180
7Calf muscle hypertrophy (HP:0008981)6.07735324
8Primary atrial arrhythmia (HP:0001692)5.98370066
9Supraventricular tachycardia (HP:0004755)5.78726892
10Abnormality of the left ventricular outflow tract (HP:0011103)5.72237253
11Subaortic stenosis (HP:0001682)5.72237253
12Supraventricular arrhythmia (HP:0005115)5.68460012
13Muscle hypertrophy of the lower extremities (HP:0008968)5.53642674
14Muscle fiber splitting (HP:0003555)5.48105931
15Lipoatrophy (HP:0100578)5.46731179
16Exercise-induced myalgia (HP:0003738)5.39574150
17Exercise-induced muscle cramps (HP:0003710)5.37833925
18Abnormality of the calf musculature (HP:0001430)5.36122238
19Syncope (HP:0001279)5.21253480
20Right ventricular cardiomyopathy (HP:0011663)5.02555003
21Prolonged QT interval (HP:0001657)4.71572893
22Hyporeflexia of lower limbs (HP:0002600)4.67022813
23Asymmetric septal hypertrophy (HP:0001670)4.61287008
24Ventricular arrhythmia (HP:0004308)4.57606969
25Bundle branch block (HP:0011710)4.56643838
26Dilated cardiomyopathy (HP:0001644)4.52079373
27Myoglobinuria (HP:0002913)4.40101561
28Palpitations (HP:0001962)4.32431795
29EMG: myopathic abnormalities (HP:0003458)4.25201814
30Ventricular fibrillation (HP:0001663)4.17982613
31Increased connective tissue (HP:0009025)3.89969746
32Heart block (HP:0012722)3.86108470
33Atrioventricular block (HP:0001678)3.78554248
34Abnormal atrioventricular conduction (HP:0005150)3.66937493
35Abnormal EKG (HP:0003115)3.63150030
36Distal arthrogryposis (HP:0005684)3.51256368
37Myotonia (HP:0002486)3.42562555
38Difficulty climbing stairs (HP:0003551)3.20224002
39Difficulty running (HP:0009046)3.17745639
40Left ventricular hypertrophy (HP:0001712)3.10605101
41Hyperkalemia (HP:0002153)3.07067694
42Rimmed vacuoles (HP:0003805)3.05044157
43Rhabdomyolysis (HP:0003201)3.02804815
44Ulnar deviation of the wrist (HP:0003049)2.87125631
45Round ear (HP:0100830)2.85189733
46Ragged-red muscle fibers (HP:0003200)2.84230191
47Myopathic facies (HP:0002058)2.81991508
48Palmoplantar keratoderma (HP:0000982)2.77185920
49Testicular atrophy (HP:0000029)2.71655649
50Type 1 muscle fiber predominance (HP:0003803)2.65334339
51Neck muscle weakness (HP:0000467)2.58563004
52Mildly elevated creatine phosphokinase (HP:0008180)2.54289000
53EMG: neuropathic changes (HP:0003445)2.54070115
54Ketoacidosis (HP:0001993)2.51161060
55Absent phalangeal crease (HP:0006109)2.48254456
56Distal lower limb muscle weakness (HP:0009053)2.46199528
57Large for gestational age (HP:0001520)2.41824088
58Severe visual impairment (HP:0001141)2.37016351
59Attenuation of retinal blood vessels (HP:0007843)2.36667094
60Diaphragmatic weakness (HP:0009113)2.36306482
61Frequent falls (HP:0002359)2.34505928
62Hypoplastic ischia (HP:0003175)2.33333328
63Limb-girdle muscle atrophy (HP:0003797)2.28333545
64Malignant hyperthermia (HP:0002047)2.24610887
65Pancreatic islet-cell hyperplasia (HP:0004510)2.20960021
66Increased variability in muscle fiber diameter (HP:0003557)2.20791972
67Areflexia of lower limbs (HP:0002522)2.19036920
68Muscle stiffness (HP:0003552)2.18213147
69Abnormality of the foot musculature (HP:0001436)2.15473178
70Double outlet right ventricle (HP:0001719)2.14628706
71Congenital malformation of the right heart (HP:0011723)2.14628706
72Sudden cardiac death (HP:0001645)2.12498630
73Fatigable weakness (HP:0003473)2.11065185
74Abnormality of the neuromuscular junction (HP:0003398)2.11065185
75Fetal akinesia sequence (HP:0001989)2.09631528
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.09593828
77Dysmetric saccades (HP:0000641)2.06676705
78Hepatic necrosis (HP:0002605)2.06521282
79Generalized muscle weakness (HP:0003324)2.06079756
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04337106
81Abnormal mitochondria in muscle tissue (HP:0008316)2.04157533
82Distal lower limb amyotrophy (HP:0008944)2.03934331
83Multiple enchondromatosis (HP:0005701)2.03688976
84Progressive muscle weakness (HP:0003323)2.03673390
85Absent/shortened dynein arms (HP:0200106)2.02812372
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.02812372
87Abnormal finger flexion creases (HP:0006143)2.02492986
88Abnormality of the ischium (HP:0003174)2.00408815
89Hamartoma of the eye (HP:0010568)1.99462161
90Weak cry (HP:0001612)1.98944846
91Abnormality of the tricuspid valve (HP:0001702)1.97888120
92Acute necrotizing encephalopathy (HP:0006965)1.97542604
93Hypoglycemic coma (HP:0001325)1.96548563
94Generalized amyotrophy (HP:0003700)1.95663792
95Abnormality of skeletal muscle fiber size (HP:0012084)1.95423110
96Bony spicule pigmentary retinopathy (HP:0007737)1.93229274
97Hyperinsulinemic hypoglycemia (HP:0000825)1.91297551
98Calcaneovalgus deformity (HP:0001848)1.90107897
99Resting tremor (HP:0002322)1.89180889
100Waddling gait (HP:0002515)1.88811849
101Congestive heart failure (HP:0001635)1.86401954
102Hypoplastic heart (HP:0001961)1.84895057
103Hip contracture (HP:0003273)1.81355830
104Foot dorsiflexor weakness (HP:0009027)1.80958093
105Muscular dystrophy (HP:0003560)1.80297526
106Scapular winging (HP:0003691)1.79245617
107Pheochromocytoma (HP:0002666)1.78960069
108Abnormality of potassium homeostasis (HP:0011042)1.78782632
109Bulbar palsy (HP:0001283)1.77331837
110Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77009143
111Dicarboxylic aciduria (HP:0003215)1.77009143
112Lymphangioma (HP:0100764)1.76054267
113Chronic hepatic failure (HP:0100626)1.75708950
114Type 2 muscle fiber atrophy (HP:0003554)1.75120869
115Abnormality of macular pigmentation (HP:0008002)1.75026213
116Bell-shaped thorax (HP:0001591)1.72164144
117Nephronophthisis (HP:0000090)1.71745848
118Gowers sign (HP:0003391)1.71142363
119Hepatocellular necrosis (HP:0001404)1.70989425
120Progressive cerebellar ataxia (HP:0002073)1.68335186
121Preauricular pit (HP:0004467)1.67872767
122Periauricular skin pits (HP:0100277)1.67872767
123Abnormality of the salivary glands (HP:0010286)1.67826899
124Conjunctival hamartoma (HP:0100780)1.67727465
125Abnormal rod and cone electroretinograms (HP:0008323)1.67687817
126Insulin-resistant diabetes mellitus (HP:0000831)1.67225613
127Acute encephalopathy (HP:0006846)1.67194230
128Increased muscle lipid content (HP:0009058)1.67141910
129Deformed tarsal bones (HP:0008119)1.65860997
130Hypoplastic left heart (HP:0004383)1.63701747
131Lower limb amyotrophy (HP:0007210)1.63045131
132Exercise intolerance (HP:0003546)1.61837104
133Ketosis (HP:0001946)1.61226619
134Abnormality of fatty-acid metabolism (HP:0004359)1.60856100
135Proximal amyotrophy (HP:0007126)1.60033634
136Cerebral edema (HP:0002181)1.58767776
137Muscle fiber atrophy (HP:0100295)1.58749478
138Skin pits (HP:0100276)1.56787089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.60101501
2OBSCN4.22089461
3PHKG23.85687361
4PHKG13.85687361
5LMTK23.76616725
6MYLK3.34707083
7DMPK3.18948289
8PKN22.86710047
9ICK2.80977309
10PLK42.76996624
11PDK42.65879773
12PDK32.65879773
13PINK12.58146664
14TRIB32.57912072
15NEK12.21372879
16PIK3CG2.14269383
17FRK1.99559539
18MAP4K21.99041976
19MARK11.94710966
20MUSK1.86018974
21STK241.83530651
22CDC42BPA1.81494257
23TESK11.73278196
24TIE11.73070791
25BCKDK1.66496894
26PIK3CA1.66063485
27PDK21.48217583
28PDGFRA1.42768127
29PRKD11.36478239
30DDR21.33780416
31TRPM71.31080810
32CAMK2D1.27584368
33PAK31.24992155
34GRK71.23718933
35MAP3K61.23249729
36PLK21.12864613
37ILK1.12121565
38STK41.11781528
39TYRO31.09666548
40RIPK11.05400487
41CDK121.04478760
42PRKAA11.03640475
43MAP3K111.03278688
44UHMK11.02729277
45ADRBK20.98179692
46PRKD20.93864016
47RPS6KC10.93746513
48RPS6KL10.93746513
49GRK10.93378517
50BMPR1B0.92614271
51STK380.91537382
52STK390.90722020
53PNCK0.90246837
54MAPK150.90207262
55PDPK10.89961018
56CAMK40.89767911
57MAPKAPK30.89647968
58ROCK10.88476689
59MAPK120.86506288
60MAP3K70.85777405
61PRKAA20.82637278
62PRKG10.81076756
63DAPK30.81056229
64STK38L0.80797155
65LATS20.80341267
66MAP3K50.80046612
67ZAK0.79122894
68RPS6KA60.77033024
69NTRK30.76241723
70MAPK130.75272877
71WNK40.74087775
72MAP3K100.71719731
73WNK10.71264121
74FLT30.70443314
75PDK10.70389980
76CAMK2A0.64571340
77MATK0.64147749
78MTOR0.60767028
79CAMK1G0.58817108
80BMX0.58255369
81LIMK10.57299461
82TGFBR20.55003098
83FGR0.54909440
84DAPK20.53305994
85MAP2K60.53277598
86AKT20.52687079
87PRKACB0.51464852
88CSK0.50500924
89MAP2K10.49395861
90CCNB10.48783425
91ROCK20.48667403
92PKN10.48193753
93GRK50.47357828
94SGK2230.46002705
95SGK4940.46002705
96RPS6KA10.45033222
97DYRK1B0.44837823
98PRKACG0.43705762
99PTK2B0.43546295
100MAPK40.42924945
101SGK20.42773349
102MAPK110.42726969
103CAMK10.41788375
104INSRR0.40317209
105TLK10.39886326
106PRKACA0.39865251
107SIK10.39745868
108MAP3K30.39118463
109CAMK2B0.36870832
110PRKG20.36158899
111MAP2K40.35814537
112OXSR10.35142206
113MAP3K40.35031092
114NTRK20.35012391
115ACVR1B0.32865395
116NEK90.32458245
117KDR0.32428993
118MAPK70.32405296
119TXK0.32362964
120CAMK2G0.30950398
121RPS6KA20.30765109
122ITK0.30350503
123PRKCG0.30132062
124EPHA30.28404081
125EPHB10.28050682
126PAK60.27971798
127STK110.27749506
128TAOK10.27010826
129WNK30.26837130
130PRKCE0.26592267
131MARK20.26299280
132MAP2K30.25501437
133RPS6KA30.25325481
134PRKCA0.24952817
135PDGFRB0.24610757
136MAPK80.24384598
137PRKD30.23705495
138ALK0.21018026
139AKT30.20834362
140SGK10.20559350
141GSK3A0.19546976
142RPS6KB20.18346229
143LATS10.16940847
144ADRBK10.16670410

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.45737753
2Cardiac muscle contraction_Homo sapiens_hsa042604.66683750
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.55083764
4Dilated cardiomyopathy_Homo sapiens_hsa054144.20290590
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.05086278
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13878430
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68107250
8Parkinsons disease_Homo sapiens_hsa050122.60816459
9Propanoate metabolism_Homo sapiens_hsa006402.60565719
10Oxidative phosphorylation_Homo sapiens_hsa001902.41981179
11Fatty acid degradation_Homo sapiens_hsa000712.37611788
12Carbon metabolism_Homo sapiens_hsa012002.25293632
13Fatty acid metabolism_Homo sapiens_hsa012122.20087762
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.12140716
15Viral myocarditis_Homo sapiens_hsa054162.00461194
16Fatty acid biosynthesis_Homo sapiens_hsa000611.85308967
17Alzheimers disease_Homo sapiens_hsa050101.82662332
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75542178
19Phototransduction_Homo sapiens_hsa047441.69764253
20Huntingtons disease_Homo sapiens_hsa050161.69339309
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61573858
22Pyruvate metabolism_Homo sapiens_hsa006201.44757117
23Biosynthesis of amino acids_Homo sapiens_hsa012301.44045505
24Morphine addiction_Homo sapiens_hsa050321.33861921
25Lysine degradation_Homo sapiens_hsa003101.30395818
26Linoleic acid metabolism_Homo sapiens_hsa005911.30083822
27Salivary secretion_Homo sapiens_hsa049701.16055065
28Nitrogen metabolism_Homo sapiens_hsa009101.11643328
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10220324
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10147458
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07180375
32Nicotine addiction_Homo sapiens_hsa050331.04945526
33Glucagon signaling pathway_Homo sapiens_hsa049221.03887087
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00760978
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.00451991
36Fructose and mannose metabolism_Homo sapiens_hsa000510.98944220
37Fatty acid elongation_Homo sapiens_hsa000620.98304390
38GABAergic synapse_Homo sapiens_hsa047270.97772802
39Arginine and proline metabolism_Homo sapiens_hsa003300.97329795
40Insulin signaling pathway_Homo sapiens_hsa049100.95576055
41Arginine biosynthesis_Homo sapiens_hsa002200.94609934
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93903508
43Butanoate metabolism_Homo sapiens_hsa006500.93751819
44Insulin resistance_Homo sapiens_hsa049310.93273789
45Adherens junction_Homo sapiens_hsa045200.87003024
46Focal adhesion_Homo sapiens_hsa045100.86985558
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86129870
48AMPK signaling pathway_Homo sapiens_hsa041520.85364332
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.83271123
50Starch and sucrose metabolism_Homo sapiens_hsa005000.82661826
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82569200
52Galactose metabolism_Homo sapiens_hsa000520.82330709
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82230685
54mTOR signaling pathway_Homo sapiens_hsa041500.81106710
55PPAR signaling pathway_Homo sapiens_hsa033200.80537148
56Calcium signaling pathway_Homo sapiens_hsa040200.79291608
57ABC transporters_Homo sapiens_hsa020100.77760997
58Cholinergic synapse_Homo sapiens_hsa047250.77232013
59Glutamatergic synapse_Homo sapiens_hsa047240.76984130
60* Tight junction_Homo sapiens_hsa045300.76675591
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76229114
62HIF-1 signaling pathway_Homo sapiens_hsa040660.75133167
63Pancreatic secretion_Homo sapiens_hsa049720.72881325
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69859404
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67761777
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.67530101
67Circadian rhythm_Homo sapiens_hsa047100.66172599
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66128985
69Sulfur relay system_Homo sapiens_hsa041220.66119277
70Oxytocin signaling pathway_Homo sapiens_hsa049210.65929177
71Serotonergic synapse_Homo sapiens_hsa047260.64455730
72Amphetamine addiction_Homo sapiens_hsa050310.61844159
73Type II diabetes mellitus_Homo sapiens_hsa049300.61587910
74Tryptophan metabolism_Homo sapiens_hsa003800.59599909
75Notch signaling pathway_Homo sapiens_hsa043300.57893093
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.57633879
77Tyrosine metabolism_Homo sapiens_hsa003500.56300440
78Bile secretion_Homo sapiens_hsa049760.53819518
79ECM-receptor interaction_Homo sapiens_hsa045120.53779395
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.53524786
81Glycerolipid metabolism_Homo sapiens_hsa005610.50554470
82Regulation of autophagy_Homo sapiens_hsa041400.49498731
83Peroxisome_Homo sapiens_hsa041460.48806630
84cAMP signaling pathway_Homo sapiens_hsa040240.48696261
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47981462
86Fat digestion and absorption_Homo sapiens_hsa049750.43136151
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42821694
88Renin secretion_Homo sapiens_hsa049240.41558701
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39320634
90Insulin secretion_Homo sapiens_hsa049110.39236589
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38342422
92beta-Alanine metabolism_Homo sapiens_hsa004100.37708995
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37649192
94VEGF signaling pathway_Homo sapiens_hsa043700.37566895
95Ether lipid metabolism_Homo sapiens_hsa005650.37207215
96Protein digestion and absorption_Homo sapiens_hsa049740.36928301
97Dopaminergic synapse_Homo sapiens_hsa047280.36801447
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36450036
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36353063
100Dorso-ventral axis formation_Homo sapiens_hsa043200.36094345
101Gap junction_Homo sapiens_hsa045400.35641325
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34743153
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34166749
104Hippo signaling pathway_Homo sapiens_hsa043900.32967624
105Proteoglycans in cancer_Homo sapiens_hsa052050.32945900
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32653034
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32143675
108Hedgehog signaling pathway_Homo sapiens_hsa043400.31503342
109Gastric acid secretion_Homo sapiens_hsa049710.30990122
110Amoebiasis_Homo sapiens_hsa051460.30645433
111Cocaine addiction_Homo sapiens_hsa050300.30059035
112Circadian entrainment_Homo sapiens_hsa047130.29832670
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29035983
114GnRH signaling pathway_Homo sapiens_hsa049120.27614407
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27044511
116Small cell lung cancer_Homo sapiens_hsa052220.25992499
117Phenylalanine metabolism_Homo sapiens_hsa003600.16996019
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.16902951
119Taste transduction_Homo sapiens_hsa047420.16894060
120Ovarian steroidogenesis_Homo sapiens_hsa049130.15374958
121Metabolic pathways_Homo sapiens_hsa011000.14053191
122Basal cell carcinoma_Homo sapiens_hsa052170.13997927
123Wnt signaling pathway_Homo sapiens_hsa043100.13067248
124MAPK signaling pathway_Homo sapiens_hsa040100.11945451
125Base excision repair_Homo sapiens_hsa034100.11483647
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10973900
127Estrogen signaling pathway_Homo sapiens_hsa049150.09327078
128Olfactory transduction_Homo sapiens_hsa047400.08747525
129Rap1 signaling pathway_Homo sapiens_hsa040150.08188047
130Renal cell carcinoma_Homo sapiens_hsa052110.07863354
131MicroRNAs in cancer_Homo sapiens_hsa052060.07371509
132mRNA surveillance pathway_Homo sapiens_hsa030150.07310029
133Pathways in cancer_Homo sapiens_hsa052000.07217431
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.05607215
135Platelet activation_Homo sapiens_hsa046110.04146708

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