MYH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of integrin activation (GO:0033623)4.23145667
2embryonic process involved in female pregnancy (GO:0060136)4.20917296
3protein localization to endosome (GO:0036010)3.60861237
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34778674
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34778674
6positive thymic T cell selection (GO:0045059)3.33966205
7positive regulation of gamma-delta T cell activation (GO:0046645)3.26778601
8endodermal cell differentiation (GO:0035987)3.15957152
9response to laminar fluid shear stress (GO:0034616)3.15573430
10regulation of translational fidelity (GO:0006450)3.15152097
11positive regulation of receptor recycling (GO:0001921)3.13060155
12protein heterotrimerization (GO:0070208)3.09035870
13antigen processing and presentation of endogenous antigen (GO:0019883)3.07027517
14apoptotic cell clearance (GO:0043277)3.03526420
15negative regulation of erythrocyte differentiation (GO:0045647)3.02644398
16regulation of gamma-delta T cell differentiation (GO:0045586)2.99655427
17Golgi transport vesicle coating (GO:0048200)2.98276428
18COPI coating of Golgi vesicle (GO:0048205)2.98276428
19establishment of apical/basal cell polarity (GO:0035089)2.97785611
20cell adhesion mediated by integrin (GO:0033627)2.97251735
21positive regulation of histone deacetylation (GO:0031065)2.96364087
22cell-substrate junction assembly (GO:0007044)2.95026983
23apoptotic process involved in morphogenesis (GO:0060561)2.94832044
24negative regulation of cell killing (GO:0031342)2.94081710
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94081710
26embryonic placenta development (GO:0001892)2.93371553
27thymic T cell selection (GO:0045061)2.89921553
28negative regulation of fatty acid transport (GO:2000192)2.88301313
29skin morphogenesis (GO:0043589)2.87810968
30barbed-end actin filament capping (GO:0051016)2.87489336
31negative thymic T cell selection (GO:0045060)2.87319839
32pinocytosis (GO:0006907)2.87255031
33dosage compensation (GO:0007549)2.85099283
34negative T cell selection (GO:0043383)2.82461769
35nuclear pore complex assembly (GO:0051292)2.79304808
36membrane raft organization (GO:0031579)2.78247868
37positive regulation of Cdc42 GTPase activity (GO:0043089)2.78020506
38cytoskeletal anchoring at plasma membrane (GO:0007016)2.76591253
39trophectodermal cell differentiation (GO:0001829)2.72898788
40mannose metabolic process (GO:0006013)2.71904650
41adherens junction assembly (GO:0034333)2.68652702
42regulation of gamma-delta T cell activation (GO:0046643)2.68381946
43positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.67964519
44mesodermal cell differentiation (GO:0048333)2.67441421
45regulation of extracellular matrix disassembly (GO:0010715)2.67291099
46hepatocyte apoptotic process (GO:0097284)2.67174049
47regulation of RNA export from nucleus (GO:0046831)2.65117203
48modulation by symbiont of host defense response (GO:0052031)2.64971694
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64971694
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64971694
51positive regulation by organism of defense response of other organism involved in symbiotic interact2.64971694
52modulation by symbiont of host immune response (GO:0052553)2.64971694
53positive regulation by symbiont of host defense response (GO:0052509)2.64971694
54proline biosynthetic process (GO:0006561)2.63414706
55heterochromatin organization (GO:0070828)2.61861133
56stress fiber assembly (GO:0043149)2.61737638
57cortical actin cytoskeleton organization (GO:0030866)2.59446877
58vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.59127854
59response to muramyl dipeptide (GO:0032495)2.56861958
60negative regulation of interleukin-12 production (GO:0032695)2.56090564
61negative regulation of anoikis (GO:2000811)2.55120304
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.54477489
63regulation of early endosome to late endosome transport (GO:2000641)2.53752051
64regulation of hippo signaling (GO:0035330)2.52295811
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51551137
66mRNA transcription (GO:0009299)2.51462041
67epithelial cell-cell adhesion (GO:0090136)2.49741269
68cortical cytoskeleton organization (GO:0030865)2.49321737
69leukocyte cell-cell adhesion (GO:0007159)2.47688106
70growth hormone receptor signaling pathway (GO:0060396)2.46888784
71positive T cell selection (GO:0043368)2.46566723
72wound healing, spreading of cells (GO:0044319)2.46549626
73positive regulation of endothelial cell apoptotic process (GO:2000353)2.45214395
74mitotic G1 DNA damage checkpoint (GO:0031571)2.45145880
75regulation of tight junction assembly (GO:2000810)2.45005712
76positive regulation of lamellipodium assembly (GO:0010592)2.44721373
77substrate-dependent cell migration (GO:0006929)2.44364815
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44275051
79hemidesmosome assembly (GO:0031581)2.43886649
80insulin-like growth factor receptor signaling pathway (GO:0048009)2.43210172
81angiogenesis involved in wound healing (GO:0060055)2.43174271
82heterotypic cell-cell adhesion (GO:0034113)2.42968213
83positive regulation of protein oligomerization (GO:0032461)2.42924106
84germ cell migration (GO:0008354)2.42814942
85negative regulation of stress fiber assembly (GO:0051497)2.42659843
86leukocyte aggregation (GO:0070486)2.42101563
87response to fluid shear stress (GO:0034405)2.41958383
88T cell selection (GO:0045058)2.41714809
89regulation of transforming growth factor beta1 production (GO:0032908)2.41235115
90vascular endothelial growth factor signaling pathway (GO:0038084)2.40928332
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38636762
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37563757
93focal adhesion assembly (GO:0048041)2.36820261
94cell-substrate adherens junction assembly (GO:0007045)2.36820261
95positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35888406
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35688796
97regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35515655
98wound healing, spreading of epidermal cells (GO:0035313)2.35437577
99collagen fibril organization (GO:0030199)2.34945931
100substrate adhesion-dependent cell spreading (GO:0034446)2.34896659
101positive regulation of protein homooligomerization (GO:0032464)2.34646632
102nuclear pore organization (GO:0006999)2.33558250
103cellular response to zinc ion (GO:0071294)2.33468861
104antigen processing and presentation via MHC class Ib (GO:0002475)2.31607370
105establishment or maintenance of monopolar cell polarity (GO:0061339)2.31185820
106establishment of monopolar cell polarity (GO:0061162)2.31185820
107activation of Rac GTPase activity (GO:0032863)2.30900667
108regulation of macrophage cytokine production (GO:0010935)2.29856846
109semaphorin-plexin signaling pathway (GO:0071526)2.29682498
110hippo signaling (GO:0035329)2.29111208
111detection of molecule of bacterial origin (GO:0032490)2.28464204
112JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.28229602
113basement membrane organization (GO:0071711)2.28184174
114natural killer cell differentiation (GO:0001779)2.28076004
115positive regulation of natural killer cell differentiation (GO:0032825)2.27890327
116regulation of necroptotic process (GO:0060544)2.27025036
117regulation of anoikis (GO:2000209)2.26992620
118regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26871653
119positive regulation of blood vessel endothelial cell migration (GO:0043536)2.26852631
120cytoplasmic mRNA processing body assembly (GO:0033962)2.26530780
121mitotic G1/S transition checkpoint (GO:0044819)2.26510643
122positive regulation of extracellular matrix organization (GO:1903055)2.25517690
123detection of other organism (GO:0098543)2.25485801
124cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.25481768
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.25457453
126tyrosine phosphorylation of STAT protein (GO:0007260)2.25442446
127regulation of T cell tolerance induction (GO:0002664)2.24928403
128response to peptidoglycan (GO:0032494)2.24791151
129cellular extravasation (GO:0045123)2.24789794
130atrioventricular valve morphogenesis (GO:0003181)2.23692602
131positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.23035208
132positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.23035208
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.23035208
134establishment of endothelial barrier (GO:0061028)2.22875536
135embryonic camera-type eye development (GO:0031076)2.22187775
136actin filament bundle assembly (GO:0051017)2.21357317
137actin filament bundle organization (GO:0061572)2.21357317
138* integrin-mediated signaling pathway (GO:0007229)2.20716297
139endocytic recycling (GO:0032456)2.20002207
140positive regulation of cell adhesion mediated by integrin (GO:0033630)2.19600180
141venous blood vessel morphogenesis (GO:0048845)2.19365524
142regulation of type I interferon-mediated signaling pathway (GO:0060338)2.19178992
143regulation of nucleobase-containing compound transport (GO:0032239)2.18892333
144actin filament depolymerization (GO:0030042)2.18710246
145positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18397050
146modulation by symbiont of host cellular process (GO:0044068)2.17993444
147hyaluronan catabolic process (GO:0030214)2.17754283
148chondrocyte proliferation (GO:0035988)2.17554886
149hypotonic response (GO:0006971)2.17201111
150response to host (GO:0075136)2.16513751
151response to host defenses (GO:0052200)2.16513751
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.16513751
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13879263
154maternal placenta development (GO:0001893)2.13668982
155negative regulation of cell junction assembly (GO:1901889)2.13515107
156negative regulation of adherens junction organization (GO:1903392)2.13515107
157macrophage activation involved in immune response (GO:0002281)2.13025642
158desmosome organization (GO:0002934)2.12174278
159detection of external biotic stimulus (GO:0098581)2.11876875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.04718186
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.65988626
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63649989
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58804424
5E2F7_22180533_ChIP-Seq_HELA_Human3.29013635
6* MYC_22102868_ChIP-Seq_BL_Human2.98383042
7* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68698528
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.66253521
9* VDR_21846776_ChIP-Seq_THP-1_Human2.66114371
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.25000872
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20461714
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14143481
13TCF7_22412390_ChIP-Seq_EML_Mouse2.13629662
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12726806
15KDM2B_26808549_Chip-Seq_DND41_Human2.09198173
16* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08498626
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08146778
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03400859
19MAF_26560356_Chip-Seq_TH1_Human2.00807757
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.94972347
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94435006
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.93141857
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90013027
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.87209878
25* UTX_26944678_Chip-Seq_JUKART_Human1.81749137
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.80661934
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79365008
28* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75819952
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74390355
30* CLOCK_20551151_ChIP-Seq_293T_Human1.71240953
31* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68506090
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68377827
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66617651
34* VDR_24763502_ChIP-Seq_THP-1_Human1.62746477
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61050051
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60096358
37MYB_26560356_Chip-Seq_TH1_Human1.59840925
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58373522
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56561614
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56557817
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.56110499
42* MYB_26560356_Chip-Seq_TH2_Human1.54726609
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53213628
44* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51381155
45* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49673161
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46398521
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.44468582
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44124608
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43976144
50* LXR_22292898_ChIP-Seq_THP-1_Human1.42477703
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42433619
52* ATF3_27146783_Chip-Seq_COLON_Human1.41188368
53* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40830292
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40189148
55* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40048375
56* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39559792
57RUNX_20019798_ChIP-Seq_JUKART_Human1.39398668
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37945306
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.37114277
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35057973
61NCOR1_26117541_ChIP-Seq_K562_Human1.34595555
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27379633
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.27001858
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26764945
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26433912
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26180423
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25523979
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25329988
69MAF_26560356_Chip-Seq_TH2_Human1.23153339
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22768849
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22202787
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22140184
73* IRF8_27001747_Chip-Seq_BMDM_Mouse1.20329752
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.17885837
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.17710969
76ZNF263_19887448_ChIP-Seq_K562_Human1.17402055
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.16703444
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.16703444
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16539079
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16417027
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.15866272
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15835863
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14566757
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.14402886
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13998705
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13998705
87TP53_22127205_ChIP-Seq_IMR90_Human1.13963135
88* GATA1_19941826_ChIP-Seq_K562_Human1.13479662
89* SPI1_23127762_ChIP-Seq_K562_Human1.13355155
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13043774
91SCL_19346495_ChIP-Seq_HPC-7_Human1.12232733
92* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09919126
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09743425
94* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09629049
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09487150
96* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06293865
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05247284
98* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05120755
99* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05086771
100* BRD4_25478319_ChIP-Seq_HGPS_Human1.04879090
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04169650
102* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03675830
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.03078465
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00386458
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00289586
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00180260
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99740183
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99131738
109GATA6_25053715_ChIP-Seq_YYC3_Human0.99116029
110* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98807741
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98743393
112* SPI1_23547873_ChIP-Seq_NB4_Human0.98036652
113TFEB_21752829_ChIP-Seq_HELA_Human0.97724669
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97023105
115* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96879464
116KDM2B_26808549_Chip-Seq_K562_Human0.96798125
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96204128
118PU_27001747_Chip-Seq_BMDM_Mouse0.95340568
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95141141
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95108844
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94556694
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94439333
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94288179
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91945881
125* ESR2_21235772_ChIP-Seq_MCF-7_Human0.91548950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.64952350
2MP0003705_abnormal_hypodermis_morpholog3.50153523
3MP0010352_gastrointestinal_tract_polyps3.34781022
4MP0009278_abnormal_bone_marrow2.69190614
5MP0005076_abnormal_cell_differentiation2.54032963
6MP0003300_gastrointestinal_ulcer2.52727593
7* MP0003566_abnormal_cell_adhesion2.21796032
8MP0005023_abnormal_wound_healing2.17192082
9MP0003279_aneurysm2.16443341
10MP0005275_abnormal_skin_tensile2.11858438
11MP0005451_abnormal_body_composition2.09909019
12MP0010368_abnormal_lymphatic_system1.99287478
13MP0002166_altered_tumor_susceptibility1.98762657
14MP0002877_abnormal_melanocyte_morpholog1.90223504
15MP0000685_abnormal_immune_system1.88960801
16MP0003303_peritoneal_inflammation1.88207000
17MP0003191_abnormal_cellular_cholesterol1.83560967
18MP0008260_abnormal_autophagy1.82152045
19* MP0003091_abnormal_cell_migration1.79197922
20MP0005623_abnormal_meninges_morphology1.76916342
21MP0003453_abnormal_keratinocyte_physiol1.61077163
22MP0005397_hematopoietic_system_phenotyp1.61017513
23MP0001545_abnormal_hematopoietic_system1.61017513
24MP0001958_emphysema1.60085785
25MP0002060_abnormal_skin_morphology1.59318333
26MP0000733_abnormal_muscle_development1.59208310
27MP0005409_darkened_coat_color1.58006275
28MP0003045_fibrosis1.57524455
29MP0003763_abnormal_thymus_physiology1.51922595
30MP0002006_tumorigenesis1.51698464
31MP0004808_abnormal_hematopoietic_stem1.50770544
32MP0010307_abnormal_tumor_latency1.48104440
33MP0002396_abnormal_hematopoietic_system1.43538784
34MP0003436_decreased_susceptibility_to1.42666571
35MP0006054_spinal_hemorrhage1.39510518
36MP0010030_abnormal_orbit_morphology1.38697816
37MP0002405_respiratory_system_inflammati1.36705511
38MP0004947_skin_inflammation1.33981182
39MP0003950_abnormal_plasma_membrane1.33459623
40MP0003448_altered_tumor_morphology1.28617280
41MP0003172_abnormal_lysosome_physiology1.27449192
42MP0002009_preneoplasia1.27406018
43MP0010234_abnormal_vibrissa_follicle1.25803990
44MP0003724_increased_susceptibility_to1.24259753
45MP0000858_altered_metastatic_potential1.23682902
46MP0004272_abnormal_basement_membrane1.23427766
47MP0009333_abnormal_splenocyte_physiolog1.21709685
48MP0005387_immune_system_phenotype1.21097772
49MP0001790_abnormal_immune_system1.21097772
50MP0001873_stomach_inflammation1.20087986
51MP0010155_abnormal_intestine_physiology1.19553456
52MP0002933_joint_inflammation1.18727481
53MP0000767_abnormal_smooth_muscle1.17446448
54MP0001800_abnormal_humoral_immune1.16412717
55MP0004858_abnormal_nervous_system1.16175299
56* MP0002086_abnormal_extraembryonic_tissu1.13531990
57MP0002796_impaired_skin_barrier1.12095073
58MP0009840_abnormal_foam_cell1.11618504
59MP0001915_intracranial_hemorrhage1.10978744
60* MP0002398_abnormal_bone_marrow1.10910977
61MP0002452_abnormal_antigen_presenting1.10463028
62MP0005164_abnormal_response_to1.10184912
63MP0000490_abnormal_crypts_of1.09363521
64MP0008057_abnormal_DNA_replication1.08139711
65MP0004197_abnormal_fetal_growth/weight/1.07174222
66MP0001243_abnormal_dermal_layer1.06152165
67MP0001851_eye_inflammation1.05098629
68MP0001835_abnormal_antigen_presentation1.04570218
69MP0005503_abnormal_tendon_morphology1.04172083
70MP0001348_abnormal_lacrimal_gland1.03450531
71* MP0005621_abnormal_cell_physiology1.01915695
72MP0000703_abnormal_thymus_morphology1.00698315
73MP0004185_abnormal_adipocyte_glucose1.00469230
74MP0001879_abnormal_lymphatic_vessel0.99378178
75MP0004883_abnormal_blood_vessel0.98974530
76MP0000689_abnormal_spleen_morphology0.98492412
77* MP0002420_abnormal_adaptive_immunity0.97984573
78MP0000013_abnormal_adipose_tissue0.97671330
79MP0003828_pulmonary_edema0.97614717
80MP0005000_abnormal_immune_tolerance0.97411578
81* MP0001819_abnormal_immune_cell0.96728983
82MP0002896_abnormal_bone_mineralization0.95534074
83MP0000350_abnormal_cell_proliferation0.95397590
84MP0001849_ear_inflammation0.95115684
85* MP0002925_abnormal_cardiovascular_devel0.94770995
86* MP0002722_abnormal_immune_system0.94740753
87MP0001542_abnormal_bone_strength0.94245841
88MP0000569_abnormal_digit_pigmentation0.94221596
89MP0005508_abnormal_skeleton_morphology0.93707018
90MP0002723_abnormal_immune_serum0.92684238
91MP0000249_abnormal_blood_vessel0.91383189
92MP0000003_abnormal_adipose_tissue0.91344328
93* MP0000716_abnormal_immune_system0.89364801
94MP0000465_gastrointestinal_hemorrhage0.89304125
95MP0009053_abnormal_anal_canal0.89204390
96MP0001730_embryonic_growth_arrest0.87788456
97MP0002168_other_aberrant_phenotype0.85965722
98MP0002998_abnormal_bone_remodeling0.85777395
99* MP0003984_embryonic_growth_retardation0.85697058
100* MP0002088_abnormal_embryonic_growth/wei0.84979890
101MP0001533_abnormal_skeleton_physiology0.84884186
102MP0001216_abnormal_epidermal_layer0.84676746
103MP0009384_cardiac_valve_regurgitation0.84533759
104MP0002019_abnormal_tumor_incidence0.84071043
105* MP0001672_abnormal_embryogenesis/_devel0.83606304
106* MP0005380_embryogenesis_phenotype0.83606304
107MP0010630_abnormal_cardiac_muscle0.83502415
108MP0006082_CNS_inflammation0.83124602
109* MP0005464_abnormal_platelet_physiology0.82872778
110MP0002419_abnormal_innate_immunity0.82829073
111MP0005390_skeleton_phenotype0.82529090
112MP0002282_abnormal_trachea_morphology0.81028849
113MP0001697_abnormal_embryo_size0.80647717
114* MP0002429_abnormal_blood_cell0.79483486
115MP0004233_abnormal_muscle_weight0.79135776
116MP0005058_abnormal_lysosome_morphology0.78823292
117MP0005025_abnormal_response_to0.78368529
118* MP0002084_abnormal_developmental_patter0.78110269
119MP0005595_abnormal_vascular_smooth0.77970296
120MP0002128_abnormal_blood_circulation0.77059945
121MP0006138_congestive_heart_failure0.76707648
122MP0005375_adipose_tissue_phenotype0.76051615
123MP0003795_abnormal_bone_structure0.75573777
124MP0000751_myopathy0.75178495
125MP0005257_abnormal_intraocular_pressure0.74955021
126MP0004510_myositis0.74831826
127* MP0001614_abnormal_blood_vessel0.74358638
128MP0005501_abnormal_skin_physiology0.73562168
129MP0000371_diluted_coat_color0.73044775

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.45579075
2Cerebral aneurysm (HP:0004944)4.41500713
3Premature rupture of membranes (HP:0001788)4.30415745
4Ulnar bowing (HP:0003031)3.63486968
5Ankle contracture (HP:0006466)3.33133574
6Shallow orbits (HP:0000586)3.25177825
7Arterial tortuosity (HP:0005116)3.22366893
8Vascular tortuosity (HP:0004948)3.12045701
9Increased density of long bones (HP:0006392)3.03438005
10Aortic dissection (HP:0002647)3.01181976
11Peritonitis (HP:0002586)2.98561165
12Aortic aneurysm (HP:0004942)2.98345079
13Dilatation of the ascending aorta (HP:0005111)2.91796786
14Osteolytic defects of the hand bones (HP:0009699)2.86177060
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.86177060
16Atrophic scars (HP:0001075)2.82941052
17Mitral valve prolapse (HP:0001634)2.80907604
18Pustule (HP:0200039)2.80508186
19Cervical subluxation (HP:0003308)2.80308904
20Alopecia of scalp (HP:0002293)2.76158411
21Increased connective tissue (HP:0009025)2.74138390
22Genu recurvatum (HP:0002816)2.65404811
23Bowing of the arm (HP:0006488)2.55392115
24Bowed forearm bones (HP:0003956)2.55392115
25Fragile skin (HP:0001030)2.39821792
26Persistence of primary teeth (HP:0006335)2.36648492
27Aneurysm (HP:0002617)2.33255668
28Spinal cord lesions (HP:0100561)2.32611427
29Syringomyelia (HP:0003396)2.32611427
30Increased variability in muscle fiber diameter (HP:0003557)2.26350835
31Wrist flexion contracture (HP:0001239)2.23214955
32Selective tooth agenesis (HP:0001592)2.21477841
33Radial bowing (HP:0002986)2.20299857
34Blue sclerae (HP:0000592)2.18152888
35Abnormality of skeletal muscle fiber size (HP:0012084)2.10762936
36Abnormality of the calcaneus (HP:0008364)2.10433614
37Flat acetabular roof (HP:0003180)2.08204672
38Absent frontal sinuses (HP:0002688)2.07951571
39Interstitial pulmonary disease (HP:0006530)2.07556856
40Bladder diverticulum (HP:0000015)2.05651503
41Short 4th metacarpal (HP:0010044)2.05373981
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05373981
43Wormian bones (HP:0002645)2.05089629
44Distal lower limb amyotrophy (HP:0008944)2.04087775
45Distal lower limb muscle weakness (HP:0009053)2.03579452
46Joint laxity (HP:0001388)2.02690551
47Difficulty climbing stairs (HP:0003551)2.01302663
48Broad metatarsal (HP:0001783)2.00727788
49Abnormality of the fingertips (HP:0001211)1.99482347
50Camptodactyly of toe (HP:0001836)1.95733362
51Eczematoid dermatitis (HP:0000976)1.95053797
52Abnormality of the peritoneum (HP:0002585)1.94026721
53Recurrent fungal infections (HP:0002841)1.92944675
54Hematochezia (HP:0002573)1.92640715
55Thin bony cortex (HP:0002753)1.90645105
56Broad face (HP:0000283)1.90410162
57Short humerus (HP:0005792)1.90007432
58Vertebral compression fractures (HP:0002953)1.90002643
59Mitral stenosis (HP:0001718)1.88320669
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.87919904
61* Abnormal platelet volume (HP:0011876)1.87357785
62Distal upper limb amyotrophy (HP:0007149)1.86058538
63Upper limb amyotrophy (HP:0009129)1.86058538
64Soft skin (HP:0000977)1.84603335
65Obstructive sleep apnea (HP:0002870)1.84155675
66Aortic regurgitation (HP:0001659)1.84072586
67Bowel diverticulosis (HP:0005222)1.84019151
68Elbow flexion contracture (HP:0002987)1.83872893
69Tibial bowing (HP:0002982)1.83568720
70Lower limb amyotrophy (HP:0007210)1.83167689
71Congenital hip dislocation (HP:0001374)1.82446461
72Achilles tendon contracture (HP:0001771)1.82365352
73Natal tooth (HP:0000695)1.81216369
74* Increased mean platelet volume (HP:0011877)1.80838635
75Abnormality of the radial head (HP:0003995)1.79852227
76Deviation of the thumb (HP:0009603)1.79308488
77Ankyloglossia (HP:0010296)1.78579615
78Short nail (HP:0001799)1.78289461
79Neonatal short-limb short stature (HP:0008921)1.76863711
80Subacute progressive viral hepatitis (HP:0006572)1.76761925
81Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76444407
82Vertebral hypoplasia (HP:0008417)1.76444407
83Long palpebral fissure (HP:0000637)1.76117461
84Overgrowth (HP:0001548)1.75498265
85Abnormality of the distal phalanges of the toes (HP:0010182)1.72935131
86Spondylolisthesis (HP:0003302)1.72358766
87Bicuspid aortic valve (HP:0001647)1.71312738
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71165106
89Cellulitis (HP:0100658)1.70669705
90Abnormal ossification of hand bones (HP:0005921)1.70357228
91Spinal rigidity (HP:0003306)1.69657255
92Gingivitis (HP:0000230)1.68908760
93Abnormality of the acetabulum (HP:0003170)1.68176966
94Urethral obstruction (HP:0000796)1.68076434
95Thick nail (HP:0001805)1.67808757
96Mitral regurgitation (HP:0001653)1.67732037
97Abnormality of oral frenula (HP:0000190)1.67338076
98Milia (HP:0001056)1.67217613
99Hemorrhage of the eye (HP:0011885)1.66618823
100Long eyelashes (HP:0000527)1.66263688
101Abnormality of dentin (HP:0010299)1.65179569
102Emphysema (HP:0002097)1.64704623
103Basal cell carcinoma (HP:0002671)1.64297652
104Dislocated radial head (HP:0003083)1.63946662
105Coarse hair (HP:0002208)1.63944608
106Abnormality of macrophages (HP:0004311)1.63610114
107IgA deficiency (HP:0002720)1.63211214
108Poikiloderma (HP:0001029)1.62643817
109Aplasia/hypoplasia of the humerus (HP:0006507)1.62558769
110T lymphocytopenia (HP:0005403)1.61874593
111Joint stiffness (HP:0001387)1.61781852
112Abnormality of the Achilles tendon (HP:0005109)1.61721311
113Mesomelia (HP:0003027)1.61501023
114Hyperextensible skin (HP:0000974)1.60513083
115Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59997355
116Biconcave vertebral bodies (HP:0004586)1.59844420
117Slender build (HP:0001533)1.59569225
118Turricephaly (HP:0000262)1.59565406
119Coxa vara (HP:0002812)1.58978431
120Follicular hyperkeratosis (HP:0007502)1.58919866
121Broad thumb (HP:0011304)1.58909096
122Flexion contracture of toe (HP:0005830)1.58069860
123Joint contractures involving the joints of the feet (HP:0100492)1.58069860
124Spontaneous hematomas (HP:0007420)1.57996827
125Long toe (HP:0010511)1.57793709
126Macroorchidism (HP:0000053)1.57600332
127Recurrent viral infections (HP:0004429)1.57281154
128Disproportionate tall stature (HP:0001519)1.57203963
129Ureteral stenosis (HP:0000071)1.57031145
130Mildly elevated creatine phosphokinase (HP:0008180)1.56574535
131Heterotopia (HP:0002282)1.56389331
132Fused cervical vertebrae (HP:0002949)1.56361040
133Abnormality of T cell number (HP:0011839)1.56251309
134Hyperacusis (HP:0010780)1.54919594
135Hallux valgus (HP:0001822)1.54351443
136Deviation of the hallux (HP:0010051)1.54308036
137Type 1 muscle fiber predominance (HP:0003803)1.53155228
138Scapular winging (HP:0003691)1.53049815
139Advanced eruption of teeth (HP:0006288)1.52822834
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.51470897
141Recurrent abscess formation (HP:0002722)1.51216852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.60156085
2TRIB33.35848580
3PRPF4B2.84768235
4DDR22.83085295
5EEF2K2.82439036
6SMG12.53792404
7MAP3K102.52834266
8CDK122.49452004
9MAP4K12.45981029
10PKN22.42753974
11STK102.37994379
12PDGFRA2.36199332
13ICK2.18818277
14BMX2.09203858
15IRAK31.77908003
16CSK1.75328370
17JAK31.73082590
18RIPK11.70481819
19MAP3K131.68131795
20LRRK21.66470710
21MST1R1.54262558
22PTK61.51168102
23FGFR41.49195377
24SIK11.48621872
25ERN11.47963447
26EPHB11.46615900
27EPHA21.37097314
28MYLK1.32928829
29RIPK41.30944036
30CDK61.30752854
31PIM11.27594202
32NEK91.25180686
33FGR1.23827780
34TYRO31.23799300
35GRK61.23725629
36PRKD21.21881690
37JAK11.21187636
38MTOR1.20509199
39PDGFRB1.18220059
40LATS11.17568772
41FGFR31.17361394
42TYK21.15333406
43PAK41.14727815
44PTK21.12741279
45TGFBR21.11511863
46PAK21.09819844
47STK381.06461863
48MAP3K111.03835364
49RPS6KB21.01873821
50ITK1.01836747
51RPS6KA21.00644845
52MARK21.00372929
53RPS6KA40.99853740
54STK30.98698808
55DMPK0.97742820
56ZAP700.97103000
57MET0.96476425
58TAOK20.95843084
59MAP3K10.93643791
60KSR20.93502948
61IRAK40.93180926
62MAP3K140.93043058
63CAMK1D0.91440329
64DYRK1B0.90400559
65NTRK10.89453965
66MATK0.89185099
67NEK20.88327232
68CHUK0.85745181
69BLK0.85556447
70ALK0.84199169
71MOS0.83940348
72MAP2K30.83416966
73HCK0.81028748
74MAP3K60.79337920
75RPS6KC10.79146426
76RPS6KL10.79146426
77MAP3K80.77240753
78PIK3CG0.77080564
79CDK40.76651540
80PIM20.75589366
81SIK20.75479631
82RPS6KA60.75187194
83TBK10.71973152
84LCK0.71803310
85FES0.71365031
86PTK2B0.70979365
87KDR0.70102996
88PDPK10.69388154
89CDK70.68748570
90SCYL20.68678796
91MAPK70.68202360
92FGFR10.67400878
93PRKG20.67289268
94IKBKB0.66792605
95TESK20.65369331
96EPHB20.65290847
97TIE10.61980037
98MARK30.61906932
99KIT0.61799585
100LMTK20.61120280
101EPHA30.60821924
102CSF1R0.59314687
103SGK30.58789526
104RET0.58239794
105MAP3K30.58024514
106FLT30.57997725
107PRKCH0.57899049
108INSR0.57135374
109TXK0.56465221
110MAPK150.55859360
111ROCK20.55615360
112JAK20.54532215
113GSK3A0.54279217
114BTK0.53797083
115WNK10.52455014
116EGFR0.52053667
117SIK30.51798425
118CAMK1G0.51164511
119NLK0.49796626
120LATS20.48737878
121MAP3K20.48540353
122MAPKAPK20.48336379
123IKBKE0.47017576
124FRK0.46983152
125MELK0.46097636
126HIPK20.46025521
127CDC42BPA0.45966678
128TESK10.45740101
129MAP3K70.44152670
130TGFBR10.43443664
131ARAF0.43410405
132RPS6KA10.42799812
133TAOK10.42280179
134PDK10.42242810
135CLK10.41891395
136MAPK110.40959628
137BRD40.40090659
138PRKD10.38883537

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.10873571
2Small cell lung cancer_Homo sapiens_hsa052221.99356339
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.99296987
4Chronic myeloid leukemia_Homo sapiens_hsa052201.94304656
5Focal adhesion_Homo sapiens_hsa045101.91415314
6ECM-receptor interaction_Homo sapiens_hsa045121.76603861
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75296374
8Viral myocarditis_Homo sapiens_hsa054161.73529502
9Primary immunodeficiency_Homo sapiens_hsa053401.71860460
10Leukocyte transendothelial migration_Homo sapiens_hsa046701.71617724
11Proteoglycans in cancer_Homo sapiens_hsa052051.70797702
12Shigellosis_Homo sapiens_hsa051311.66946535
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65496713
14MicroRNAs in cancer_Homo sapiens_hsa052061.60256445
15Other glycan degradation_Homo sapiens_hsa005111.59036929
16Leishmaniasis_Homo sapiens_hsa051401.58636896
17B cell receptor signaling pathway_Homo sapiens_hsa046621.48955691
18Notch signaling pathway_Homo sapiens_hsa043301.45773115
19Osteoclast differentiation_Homo sapiens_hsa043801.44646379
20mTOR signaling pathway_Homo sapiens_hsa041501.43561960
21Toxoplasmosis_Homo sapiens_hsa051451.42822227
22Pancreatic cancer_Homo sapiens_hsa052121.42672776
23Measles_Homo sapiens_hsa051621.42622574
24Acute myeloid leukemia_Homo sapiens_hsa052211.42605099
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.41178197
26Bladder cancer_Homo sapiens_hsa052191.41015164
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39452553
28p53 signaling pathway_Homo sapiens_hsa041151.38665159
29Amoebiasis_Homo sapiens_hsa051461.33884379
30* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30995038
31Apoptosis_Homo sapiens_hsa042101.29796994
32Antigen processing and presentation_Homo sapiens_hsa046121.27946556
33Hepatitis B_Homo sapiens_hsa051611.27004744
34Viral carcinogenesis_Homo sapiens_hsa052031.26476613
35T cell receptor signaling pathway_Homo sapiens_hsa046601.25704214
36Platelet activation_Homo sapiens_hsa046111.21476070
37HTLV-I infection_Homo sapiens_hsa051661.19279689
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18468033
39Fatty acid biosynthesis_Homo sapiens_hsa000611.15777331
40Malaria_Homo sapiens_hsa051441.15290668
41TNF signaling pathway_Homo sapiens_hsa046681.14107048
42VEGF signaling pathway_Homo sapiens_hsa043701.12811587
43Hippo signaling pathway_Homo sapiens_hsa043901.12024755
44Prostate cancer_Homo sapiens_hsa052151.10245144
45Colorectal cancer_Homo sapiens_hsa052101.09076396
46Lysine degradation_Homo sapiens_hsa003101.06573411
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.05696663
48TGF-beta signaling pathway_Homo sapiens_hsa043501.05459749
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03716161
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03551117
51Hematopoietic cell lineage_Homo sapiens_hsa046401.01618579
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99151434
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98386373
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.98331492
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.96380187
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95562153
57Non-small cell lung cancer_Homo sapiens_hsa052230.94599936
58Endometrial cancer_Homo sapiens_hsa052130.94281913
59Legionellosis_Homo sapiens_hsa051340.92477959
60Herpes simplex infection_Homo sapiens_hsa051680.92218402
61ErbB signaling pathway_Homo sapiens_hsa040120.91223844
62Pathways in cancer_Homo sapiens_hsa052000.87548680
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87105091
64GnRH signaling pathway_Homo sapiens_hsa049120.86759843
65Prion diseases_Homo sapiens_hsa050200.86571456
66Chemokine signaling pathway_Homo sapiens_hsa040620.86395365
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86373858
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85790648
69Base excision repair_Homo sapiens_hsa034100.85255992
70HIF-1 signaling pathway_Homo sapiens_hsa040660.85037118
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.84626506
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84005369
73* Salmonella infection_Homo sapiens_hsa051320.82861470
74Inositol phosphate metabolism_Homo sapiens_hsa005620.82500873
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.79944109
76Prolactin signaling pathway_Homo sapiens_hsa049170.79056173
77Tuberculosis_Homo sapiens_hsa051520.78656452
78Rap1 signaling pathway_Homo sapiens_hsa040150.78492257
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78191396
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77304835
81Choline metabolism in cancer_Homo sapiens_hsa052310.77201215
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77001673
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75989253
84Estrogen signaling pathway_Homo sapiens_hsa049150.75712658
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75656925
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.74836976
87Dorso-ventral axis formation_Homo sapiens_hsa043200.74450224
88Renal cell carcinoma_Homo sapiens_hsa052110.74361720
89Influenza A_Homo sapiens_hsa051640.74274052
90Glioma_Homo sapiens_hsa052140.73150846
91Pertussis_Homo sapiens_hsa051330.73048125
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73017616
93FoxO signaling pathway_Homo sapiens_hsa040680.71307694
94Insulin signaling pathway_Homo sapiens_hsa049100.69741483
95Phagosome_Homo sapiens_hsa041450.69566289
96Cell cycle_Homo sapiens_hsa041100.69350480
97Insulin resistance_Homo sapiens_hsa049310.69347612
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68786260
99Thyroid cancer_Homo sapiens_hsa052160.68780508
100Epstein-Barr virus infection_Homo sapiens_hsa051690.67663931
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.66756098
102Endocytosis_Homo sapiens_hsa041440.65664363
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65119283
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64656944
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64606235
106Lysosome_Homo sapiens_hsa041420.64021829
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63269938
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62876482
109Hepatitis C_Homo sapiens_hsa051600.62029083
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61594140
111Melanoma_Homo sapiens_hsa052180.61283707
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61149641
113Basal cell carcinoma_Homo sapiens_hsa052170.60319838
114Pentose phosphate pathway_Homo sapiens_hsa000300.58178132
115Staphylococcus aureus infection_Homo sapiens_hsa051500.57612718
116MAPK signaling pathway_Homo sapiens_hsa040100.57156868
117Galactose metabolism_Homo sapiens_hsa000520.56824114
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.56430458
119mRNA surveillance pathway_Homo sapiens_hsa030150.56351382
120* Tight junction_Homo sapiens_hsa045300.56166152
121DNA replication_Homo sapiens_hsa030300.56084873
122One carbon pool by folate_Homo sapiens_hsa006700.56083693
123Dilated cardiomyopathy_Homo sapiens_hsa054140.55707080

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