MYL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.71155967
2translational termination (GO:0006415)7.31073676
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.18352003
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.18352003
5ribosomal small subunit biogenesis (GO:0042274)6.45305883
6translational elongation (GO:0006414)6.41147056
7antigen processing and presentation via MHC class Ib (GO:0002475)6.31129607
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.26250564
9cotranslational protein targeting to membrane (GO:0006613)6.12646013
10protein targeting to ER (GO:0045047)6.11443839
11antigen processing and presentation of endogenous antigen (GO:0019883)5.89891896
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.84194726
13protein localization to endoplasmic reticulum (GO:0070972)5.73881961
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.72515024
15viral life cycle (GO:0019058)5.63888682
16behavioral response to nicotine (GO:0035095)5.62270145
17cellular protein complex disassembly (GO:0043624)5.56356946
18definitive hemopoiesis (GO:0060216)5.35039436
19maturation of SSU-rRNA (GO:0030490)5.35038062
20protein complex disassembly (GO:0043241)5.12140769
21translational initiation (GO:0006413)5.09241668
22macromolecular complex disassembly (GO:0032984)4.72280244
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.68927605
24negative regulation of erythrocyte differentiation (GO:0045647)4.49018005
25positive regulation of B cell differentiation (GO:0045579)4.46914703
26positive regulation of gamma-delta T cell activation (GO:0046645)4.29094340
27nuclear-transcribed mRNA catabolic process (GO:0000956)4.09654244
28response to interferon-beta (GO:0035456)4.08692355
29protein targeting to membrane (GO:0006612)4.07110585
30piRNA metabolic process (GO:0034587)4.00634533
31mRNA catabolic process (GO:0006402)3.92838948
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90700003
33platelet dense granule organization (GO:0060155)3.90419309
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.84013811
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.79872339
36megakaryocyte development (GO:0035855)3.73731061
37RNA catabolic process (GO:0006401)3.70845415
38negative regulation of telomere maintenance (GO:0032205)3.66780327
39DNA deamination (GO:0045006)3.66083213
40positive regulation of granulocyte differentiation (GO:0030854)3.59492703
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.57064236
42NADH dehydrogenase complex assembly (GO:0010257)3.57064236
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57064236
44B cell receptor signaling pathway (GO:0050853)3.47630832
45protein complex biogenesis (GO:0070271)3.46947409
46cellular ketone body metabolic process (GO:0046950)3.46867622
47ribosomal large subunit biogenesis (GO:0042273)3.46352101
48T cell homeostasis (GO:0043029)3.45966142
49response to pheromone (GO:0019236)3.45553447
50regulation of gamma-delta T cell differentiation (GO:0045586)3.44633767
51DNA unwinding involved in DNA replication (GO:0006268)3.44615172
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43902257
53mast cell activation involved in immune response (GO:0002279)3.39000327
54mast cell degranulation (GO:0043303)3.39000327
55negative regulation of phagocytosis (GO:0050765)3.37966670
56mast cell activation (GO:0045576)3.37153292
57respiratory chain complex IV assembly (GO:0008535)3.35433213
58nonmotile primary cilium assembly (GO:0035058)3.35155777
59mature B cell differentiation involved in immune response (GO:0002313)3.33106836
60regulation of B cell differentiation (GO:0045577)3.33054264
61DNA methylation involved in gamete generation (GO:0043046)3.32565190
62purine-containing compound salvage (GO:0043101)3.30501886
63mitochondrial respiratory chain complex assembly (GO:0033108)3.26500008
64telomere maintenance via semi-conservative replication (GO:0032201)3.25328904
65Peyers patch development (GO:0048541)3.22317995
66mucosal-associated lymphoid tissue development (GO:0048537)3.22317995
67behavioral response to ethanol (GO:0048149)3.21668198
68response to interferon-alpha (GO:0035455)3.16681966
69T cell apoptotic process (GO:0070231)3.16497030
70tryptophan catabolic process (GO:0006569)3.16095883
71indole-containing compound catabolic process (GO:0042436)3.16095883
72indolalkylamine catabolic process (GO:0046218)3.16095883
73epithelial cilium movement (GO:0003351)3.15809024
74indolalkylamine metabolic process (GO:0006586)3.15676700
75translation (GO:0006412)3.15648129
76DNA strand elongation involved in DNA replication (GO:0006271)3.14737046
77ribonucleoprotein complex biogenesis (GO:0022613)3.14249212
78ncRNA 3-end processing (GO:0043628)3.13282997
79lymph node development (GO:0048535)3.12704220
80ketone body metabolic process (GO:1902224)3.11706546
81regulation of gamma-delta T cell activation (GO:0046643)3.11533507
82axoneme assembly (GO:0035082)3.07954256
83lymphoid progenitor cell differentiation (GO:0002320)3.07455330
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07351834
85energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07256277
86ATP synthesis coupled proton transport (GO:0015986)3.07256277
87water-soluble vitamin biosynthetic process (GO:0042364)3.06723676
88DNA strand elongation (GO:0022616)3.06339301
89kynurenine metabolic process (GO:0070189)3.04752577
90protein-cofactor linkage (GO:0018065)3.04411941
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04039951
92preassembly of GPI anchor in ER membrane (GO:0016254)3.03206317
93negative regulation of RNA splicing (GO:0033119)2.99149053
94pentose-phosphate shunt (GO:0006098)2.96351122
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95191309
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93582003
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93197209
98leukocyte homeostasis (GO:0001776)2.91131067
99synaptic transmission, cholinergic (GO:0007271)2.90702037
100secretory granule organization (GO:0033363)2.89989205
101regulation of cilium movement (GO:0003352)2.89654054
102tryptophan metabolic process (GO:0006568)2.88454863
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.88300798
104cellular hyperosmotic response (GO:0071474)2.87680374
105lymphocyte apoptotic process (GO:0070227)2.87429133
106execution phase of apoptosis (GO:0097194)2.85993571
107retinal cone cell development (GO:0046549)2.85060909
108electron transport chain (GO:0022900)2.83198508
109inositol phosphate catabolic process (GO:0071545)2.81500304
110response to type I interferon (GO:0034340)2.81486519
111cellular response to type I interferon (GO:0071357)2.80444584
112type I interferon signaling pathway (GO:0060337)2.80444584
113cilium morphogenesis (GO:0060271)2.78953057
114formation of translation preinitiation complex (GO:0001731)2.78949033
115reciprocal meiotic recombination (GO:0007131)2.78906175
116reciprocal DNA recombination (GO:0035825)2.78906175
117cytochrome complex assembly (GO:0017004)2.78672173
118mannosylation (GO:0097502)2.78649192
119natural killer cell differentiation (GO:0001779)2.78563735
120regulation of action potential (GO:0098900)2.78435163
121somite development (GO:0061053)2.78285815
122protein neddylation (GO:0045116)2.78093508
123nucleosome disassembly (GO:0006337)2.78031353
124protein-DNA complex disassembly (GO:0032986)2.78031353
125lymphocyte homeostasis (GO:0002260)2.76709818
126pyrimidine nucleobase catabolic process (GO:0006208)2.76646635
127telomere maintenance via recombination (GO:0000722)2.75991552
128detection of light stimulus involved in sensory perception (GO:0050962)2.75259701
129detection of light stimulus involved in visual perception (GO:0050908)2.75259701
130respiratory electron transport chain (GO:0022904)2.74059522
131rhodopsin mediated signaling pathway (GO:0016056)2.73455403
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72383516
133regulation of B cell receptor signaling pathway (GO:0050855)2.71245594
134protein polyglutamylation (GO:0018095)2.70903802
135L-fucose catabolic process (GO:0042355)2.70773207
136fucose catabolic process (GO:0019317)2.70773207
137L-fucose metabolic process (GO:0042354)2.70773207
138auditory receptor cell stereocilium organization (GO:0060088)2.70740519
139response to protozoan (GO:0001562)2.70546427
140sulfation (GO:0051923)2.70166746
141inositol phosphate dephosphorylation (GO:0046855)2.69569443
142phosphorylated carbohydrate dephosphorylation (GO:0046838)2.69569443
143photoreceptor cell development (GO:0042461)2.69070715
144regulation of regulatory T cell differentiation (GO:0045589)2.68202380
145kidney morphogenesis (GO:0060993)2.68192437
146chaperone-mediated protein transport (GO:0072321)2.67726226
147regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67207763
148ubiquinone metabolic process (GO:0006743)2.66983428
149cellular response to interferon-beta (GO:0035458)2.66884855
150cilium movement (GO:0003341)2.62202643
151defense response to protozoan (GO:0042832)2.61837376
152deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61458532
153primary amino compound metabolic process (GO:1901160)2.60087413
154establishment of integrated proviral latency (GO:0075713)2.60048123
155photoreceptor cell maintenance (GO:0045494)2.59079604
156immunoglobulin mediated immune response (GO:0016064)2.58790940
157pseudouridine synthesis (GO:0001522)2.58337280
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56209803
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56209803
160establishment of protein localization to membrane (GO:0090150)2.55285854
161ubiquinone biosynthetic process (GO:0006744)2.55145007
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54355935
163cullin deneddylation (GO:0010388)2.54165159
164mitotic recombination (GO:0006312)2.53697555
165mature B cell differentiation (GO:0002335)2.53573543
166protein deneddylation (GO:0000338)2.51026965
167IMP metabolic process (GO:0046040)2.51021829
168cilium organization (GO:0044782)2.50588802
169neuronal action potential (GO:0019228)2.49191951
170regulation of histone H3-K9 methylation (GO:0051570)2.48588521
171regulation of nuclear cell cycle DNA replication (GO:0033262)2.47724038
1723-UTR-mediated mRNA stabilization (GO:0070935)2.47639254
173positive regulation of histone deacetylation (GO:0031065)2.47088764
174regulation of meiosis I (GO:0060631)2.46721292
175indole-containing compound metabolic process (GO:0042430)2.45573662
176phospholipid scrambling (GO:0017121)2.45045197
177regulation of microtubule-based movement (GO:0060632)2.44924259
178endosome to melanosome transport (GO:0035646)2.44583863
179exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44564075
180nucleobase catabolic process (GO:0046113)2.44499014
181GPI anchor metabolic process (GO:0006505)2.42902900
182cilium assembly (GO:0042384)2.42237022
183regulation of memory T cell differentiation (GO:0043380)2.41872267
184neuron fate determination (GO:0048664)2.40905982
185regulation of telomere maintenance (GO:0032204)2.38988158
186opioid receptor signaling pathway (GO:0038003)2.38402680
187gamma-aminobutyric acid transport (GO:0015812)2.35474295
188retinal ganglion cell axon guidance (GO:0031290)2.35411208
189negative regulation of mast cell activation (GO:0033004)2.33581545
190cilium or flagellum-dependent cell motility (GO:0001539)2.33212465
191inner ear receptor stereocilium organization (GO:0060122)2.32608496
192proton transport (GO:0015992)2.32323985
193nephron tubule morphogenesis (GO:0072078)2.31979181
194nephron epithelium morphogenesis (GO:0072088)2.31979181
195ribosomal small subunit assembly (GO:0000028)10.0430905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.05082532
2ZNF274_21170338_ChIP-Seq_K562_Hela4.04842257
3SCL_19346495_ChIP-Seq_HPC-7_Human3.75763277
4EZH2_22144423_ChIP-Seq_EOC_Human3.56178163
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52016730
6VDR_22108803_ChIP-Seq_LS180_Human3.45652841
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36756420
8MYC_22102868_ChIP-Seq_BL_Human3.31945810
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23225157
10VDR_21846776_ChIP-Seq_THP-1_Human3.00993456
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99057388
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.94885507
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85849570
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.82488618
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.76540498
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.76407146
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75854618
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.68687335
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67368117
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60022382
21IGF1R_20145208_ChIP-Seq_DFB_Human2.59225810
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.46031800
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45915829
24GBX2_23144817_ChIP-Seq_PC3_Human2.35946204
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35138347
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34439959
27FUS_26573619_Chip-Seq_HEK293_Human2.21521040
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.18194012
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10631210
30VDR_24763502_ChIP-Seq_THP-1_Human2.09968694
31EWS_26573619_Chip-Seq_HEK293_Human2.07941589
32TAF15_26573619_Chip-Seq_HEK293_Human2.07510954
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07384954
34SPI1_23547873_ChIP-Seq_NB4_Human2.07119906
35ERG_20887958_ChIP-Seq_HPC-7_Mouse2.05290409
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05173882
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04513713
38CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02254546
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00467081
40* P300_19829295_ChIP-Seq_ESCs_Human1.99892791
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.96710271
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95859247
43MYB_26560356_Chip-Seq_TH2_Human1.95696348
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94430184
45TCF7_22412390_ChIP-Seq_EML_Mouse1.92964561
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91935915
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.90149155
48MAF_26560356_Chip-Seq_TH1_Human1.89599547
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87351261
50UTX_26944678_Chip-Seq_JUKART_Human1.86153543
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.84370554
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.82930690
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82408544
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82043759
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80558268
56MYB_26560356_Chip-Seq_TH1_Human1.79917055
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77282699
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75955371
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75603891
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74613755
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.73670117
62TP53_22573176_ChIP-Seq_HFKS_Human1.73174124
63XRN2_22483619_ChIP-Seq_HELA_Human1.72969670
64* ER_23166858_ChIP-Seq_MCF-7_Human1.72428070
65IRF1_19129219_ChIP-ChIP_H3396_Human1.72027552
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71901089
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70790067
68CIITA_25753668_ChIP-Seq_RAJI_Human1.69724562
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.69468196
70* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68836027
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.65096497
72VDR_23849224_ChIP-Seq_CD4+_Human1.64968640
73FOXP3_21729870_ChIP-Seq_TREG_Human1.64000105
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63973760
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63175599
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62877063
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.62749348
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61804066
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61787288
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60692804
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60661532
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59290919
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58146929
84BCAT_22108803_ChIP-Seq_LS180_Human1.56548442
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55048818
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.53471257
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53303885
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52646795
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51639435
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.50203224
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49624336
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49117501
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48327793
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47658225
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47279645
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46862064
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46011100
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46011100
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44261612
100SOX2_19829295_ChIP-Seq_ESCs_Human1.43994403
101NANOG_19829295_ChIP-Seq_ESCs_Human1.43994403
102REST_21632747_ChIP-Seq_MESCs_Mouse1.43609035
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41427962
104RUNX_20019798_ChIP-Seq_JUKART_Human1.41015782
105MYC_18940864_ChIP-ChIP_HL60_Human1.40269586
106SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40215563
107MAF_26560356_Chip-Seq_TH2_Human1.38503695
108CBP_20019798_ChIP-Seq_JUKART_Human1.37746753
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37746753
110GABP_17652178_ChIP-ChIP_JURKAT_Human1.37731710
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36018821
112AR_25329375_ChIP-Seq_VCAP_Human1.35913400
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34960218
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.34830395
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34586598
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33591765
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.33591765
118STAT3_23295773_ChIP-Seq_U87_Human1.33130475
119ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31285713
120IRF8_27001747_Chip-Seq_BMDM_Mouse1.30370468
121AR_21572438_ChIP-Seq_LNCaP_Human1.30124475
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30047934
123SMAD4_21799915_ChIP-Seq_A2780_Human1.29080292
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28729182
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28585983
126RNF2_27304074_Chip-Seq_NSC_Mouse1.27291228
127TCF4_22108803_ChIP-Seq_LS180_Human1.26654965
128* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25116130
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.25106002
130SPI1_23127762_ChIP-Seq_K562_Human1.24180662
131SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23548280
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22986892
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21879618
134* TCF4_23295773_ChIP-Seq_U87_Human1.21875865
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21311380
136HOXB7_26014856_ChIP-Seq_BT474_Human1.20962409
137EED_16625203_ChIP-ChIP_MESCs_Mouse1.19187914
138TTF2_22483619_ChIP-Seq_HELA_Human1.19054856
139NFE2_27457419_Chip-Seq_LIVER_Mouse1.18431980
140AR_20517297_ChIP-Seq_VCAP_Human1.18347857
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.17199756
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17037880
143NCOR_22424771_ChIP-Seq_293T_Human1.17012529
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.16995676
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16608298
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16180323
147KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16158068
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15833232
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15220543
150RUNX2_22187159_ChIP-Seq_PCA_Human1.13983922
151GATA1_22025678_ChIP-Seq_K562_Human1.13963865
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13963734
153EZH2_27304074_Chip-Seq_ESCs_Mouse1.12664600
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11500104
155FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10978431
156CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10901394
157STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10484691
158MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09933663
159ELK3_25401928_ChIP-Seq_HUVEC_Human1.09914353
160POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09415533
161NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08249785
162FLI1_21867929_ChIP-Seq_TH2_Mouse1.07807384
163ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06966468
164TP63_19390658_ChIP-ChIP_HaCaT_Human1.06861632
165MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06843648
166OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06254426
167EZH2_27294783_Chip-Seq_NPCs_Mouse1.06161005
168REST_18959480_ChIP-ChIP_MESCs_Mouse1.05586102
169SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05521424
170MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05281496
171E2F1_21310950_ChIP-Seq_MCF-7_Human1.02317757
172GATA1_19941827_ChIP-Seq_MEL_Mouse1.02128755
173GATA3_27048872_Chip-Seq_THYMUS_Human1.02045887
174KDM2B_26808549_Chip-Seq_DND41_Human1.01266678
175ELK1_19687146_ChIP-ChIP_HELA_Human1.00798787
176PRDM14_20953172_ChIP-Seq_ESCs_Human1.00554963
177EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99703368
178ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98952186
179GABP_19822575_ChIP-Seq_HepG2_Human0.98805300
180JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98100618
181FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97926068
182CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97825681
183FOXH1_21741376_ChIP-Seq_EPCs_Human0.96852635
184CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96146045
185E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94540256
186PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94332536
187HTT_18923047_ChIP-ChIP_STHdh_Human0.94070605
188CRX_20693478_ChIP-Seq_RETINA_Mouse0.93476577
189KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91602306
190BCL6_27268052_Chip-Seq_Bcells_Human0.90138860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.52328636
2MP0004808_abnormal_hematopoietic_stem3.93827253
3MP0000685_abnormal_immune_system3.63068509
4MP0001835_abnormal_antigen_presentation3.47844295
5MP0003011_delayed_dark_adaptation3.31530874
6MP0003136_yellow_coat_color3.08901994
7MP0001545_abnormal_hematopoietic_system2.91025922
8MP0005397_hematopoietic_system_phenotyp2.91025922
9MP0002837_dystrophic_cardiac_calcinosis2.90932051
10MP0005464_abnormal_platelet_physiology2.88454825
11MP0009785_altered_susceptibility_to2.84712438
12MP0002398_abnormal_bone_marrow2.75229407
13MP0001800_abnormal_humoral_immune2.67773186
14MP0006292_abnormal_olfactory_placode2.56694478
15MP0003763_abnormal_thymus_physiology2.54378469
16MP0000569_abnormal_digit_pigmentation2.54353664
17MP0005551_abnormal_eye_electrophysiolog2.53807495
18MP0009278_abnormal_bone_marrow2.47709427
19MP0000689_abnormal_spleen_morphology2.41668913
20MP0005174_abnormal_tail_pigmentation2.41279791
21MP0003195_calcinosis2.40985198
22MP0002102_abnormal_ear_morphology2.38222028
23MP0005671_abnormal_response_to2.37268979
24MP0003436_decreased_susceptibility_to2.37071733
25MP0002653_abnormal_ependyma_morphology2.36478051
26MP0001968_abnormal_touch/_nociception2.35638043
27MP0002722_abnormal_immune_system2.33277085
28MP0002452_abnormal_antigen_presenting2.32467701
29MP0002420_abnormal_adaptive_immunity2.30874784
30MP0002723_abnormal_immune_serum2.28641839
31MP0005025_abnormal_response_to2.28027406
32MP0001819_abnormal_immune_cell2.27115634
33MP0000716_abnormal_immune_system2.26229118
34MP0002166_altered_tumor_susceptibility2.25619755
35MP0002638_abnormal_pupillary_reflex2.24949932
36MP0000465_gastrointestinal_hemorrhage2.23904717
37MP0000490_abnormal_crypts_of2.12412528
38MP0000703_abnormal_thymus_morphology2.11939698
39MP0002429_abnormal_blood_cell2.07328227
40MP0006072_abnormal_retinal_apoptosis2.05045138
41MP0009379_abnormal_foot_pigmentation2.04394113
42MP0001986_abnormal_taste_sensitivity2.03973962
43MP0001873_stomach_inflammation2.03141058
44MP0003646_muscle_fatigue2.00025883
45MP0003787_abnormal_imprinting1.99293836
46MP0008875_abnormal_xenobiotic_pharmacok1.94335556
47MP0005646_abnormal_pituitary_gland1.92948880
48MP0003880_abnormal_central_pattern1.91430365
49MP0001529_abnormal_vocalization1.91386418
50MP0005075_abnormal_melanosome_morpholog1.88701965
51MP0005000_abnormal_immune_tolerance1.87772166
52MP0005253_abnormal_eye_physiology1.86587215
53MP0009333_abnormal_splenocyte_physiolog1.85100235
54MP0002938_white_spotting1.82456169
55MP0003866_abnormal_defecation1.82032734
56MP0002736_abnormal_nociception_after1.81535456
57MP0009745_abnormal_behavioral_response1.81372714
58MP0002272_abnormal_nervous_system1.81342877
59MP0002095_abnormal_skin_pigmentation1.80669656
60MP0010094_abnormal_chromosome_stability1.80336820
61MP0002148_abnormal_hypersensitivity_rea1.78135905
62MP0010155_abnormal_intestine_physiology1.76290518
63MP0004885_abnormal_endolymph1.76011892
64MP0001790_abnormal_immune_system1.76003530
65MP0005387_immune_system_phenotype1.76003530
66MP0005084_abnormal_gallbladder_morpholo1.75754500
67MP0002419_abnormal_innate_immunity1.73495688
68MP0001984_abnormal_olfaction1.70666875
69MP0002928_abnormal_bile_duct1.70314107
70MP0003693_abnormal_embryo_hatching1.66369825
71MP0009046_muscle_twitch1.65960840
72MP0002876_abnormal_thyroid_physiology1.62653765
73MP0004133_heterotaxia1.61596371
74MP0002405_respiratory_system_inflammati1.60693562
75MP0010386_abnormal_urinary_bladder1.60207180
76MP0001501_abnormal_sleep_pattern1.60145935
77MP0002006_tumorigenesis1.58705375
78MP0000372_irregular_coat_pigmentation1.57272555
79MP0001853_heart_inflammation1.54527091
80MP0005409_darkened_coat_color1.54418280
81MP0004142_abnormal_muscle_tone1.53183943
82MP0006276_abnormal_autonomic_nervous1.48322444
83MP0008007_abnormal_cellular_replicative1.47855346
84MP0005171_absent_coat_pigmentation1.47452695
85MP0003300_gastrointestinal_ulcer1.46720744
86MP0001486_abnormal_startle_reflex1.46140264
87MP0003077_abnormal_cell_cycle1.42939219
88MP0008872_abnormal_physiological_respon1.41956533
89MP0001485_abnormal_pinna_reflex1.40609007
90MP0002572_abnormal_emotion/affect_behav1.36569157
91MP0002019_abnormal_tumor_incidence1.36470374
92MP0001845_abnormal_inflammatory_respons1.35843936
93MP0000631_abnormal_neuroendocrine_gland1.35454562
94MP0008058_abnormal_DNA_repair1.32666058
95MP0000427_abnormal_hair_cycle1.29923713
96MP0003724_increased_susceptibility_to1.29624658
97MP0004947_skin_inflammation1.28732974
98MP0004957_abnormal_blastocyst_morpholog1.28096033
99MP0004145_abnormal_muscle_electrophysio1.26182677
100MP0005645_abnormal_hypothalamus_physiol1.25350233
101MP0005085_abnormal_gallbladder_physiolo1.25069132
102MP0003943_abnormal_hepatobiliary_system1.24700918
103MP0003890_abnormal_embryonic-extraembry1.22238634
104MP0004043_abnormal_pH_regulation1.21771788
105MP0004742_abnormal_vestibular_system1.18798577
106MP0002160_abnormal_reproductive_system1.17657812
107MP0003303_peritoneal_inflammation1.16966482
108MP0002557_abnormal_social/conspecific_i1.15860869
109MP0003121_genomic_imprinting1.14712068
110MP0002733_abnormal_thermal_nociception1.14138781
111MP0001970_abnormal_pain_threshold1.14035193
112MP0005423_abnormal_somatic_nervous1.12307009
113MP0002064_seizures1.12262142
114MP0005195_abnormal_posterior_eye1.12051982
115MP0003122_maternal_imprinting1.10178882
116MP0008057_abnormal_DNA_replication1.10128823
117MP0002063_abnormal_learning/memory/cond1.09198929
118MP0001905_abnormal_dopamine_level1.06408012
119MP0000313_abnormal_cell_death1.05795204
120MP0005389_reproductive_system_phenotype1.05580244
121MP0002735_abnormal_chemical_nociception1.05527998
122MP0003635_abnormal_synaptic_transmissio1.03849233
123MP0002138_abnormal_hepatobiliary_system1.03842347
124MP0000778_abnormal_nervous_system1.03127547
125MP0008469_abnormal_protein_level1.02847134
126MP0002734_abnormal_mechanical_nocicepti1.00334950
127MP0000015_abnormal_ear_pigmentation1.00061759
128MP0002933_joint_inflammation0.98876125
129MP0002067_abnormal_sensory_capabilities0.98826980
130MP0002752_abnormal_somatic_nervous0.98665099
131MP0001293_anophthalmia0.97613271
132MP0003111_abnormal_nucleus_morphology0.96874407
133MP0000026_abnormal_inner_ear0.96321874
134MP0008789_abnormal_olfactory_epithelium0.95089436
135MP0002163_abnormal_gland_morphology0.94457733
136MP0000538_abnormal_urinary_bladder0.93684339
137MP0001764_abnormal_homeostasis0.91100620
138MP0003137_abnormal_impulse_conducting0.91057075
139MP0004924_abnormal_behavior0.89078150
140MP0005386_behavior/neurological_phenoty0.89078150
141MP0002277_abnormal_respiratory_mucosa0.88695839
142MP0003718_maternal_effect0.87980209
143MP0002822_catalepsy0.86745528
144MP0001502_abnormal_circadian_rhythm0.85964477
145MP0002184_abnormal_innervation0.84691022
146MP0001963_abnormal_hearing_physiology0.84443891
147MP0010307_abnormal_tumor_latency0.83525487
148MP0006054_spinal_hemorrhage0.83374797
149MP0001324_abnormal_eye_pigmentation0.82441571
150MP0005220_abnormal_exocrine_pancreas0.81393368
151MP0005379_endocrine/exocrine_gland_phen0.81186073
152MP0001851_eye_inflammation0.79697620
153MP0005167_abnormal_blood-brain_barrier0.79276907
154MP0004215_abnormal_myocardial_fiber0.78739071
155MP0003191_abnormal_cellular_cholesterol0.78147238
156MP0005410_abnormal_fertilization0.78071913
157MP0005391_vision/eye_phenotype0.77913952
158MP0000955_abnormal_spinal_cord0.76485027
159MP0008995_early_reproductive_senescence0.76294111
160MP0002229_neurodegeneration0.75595552
161MP0001188_hyperpigmentation0.73612565
162MP0003698_abnormal_male_reproductive0.73350202
163MP0002751_abnormal_autonomic_nervous0.72786083
164MP0000477_abnormal_intestine_morphology0.71990268
165MP0001533_abnormal_skeleton_physiology0.71401558
166MP0002877_abnormal_melanocyte_morpholog0.71038473
167MP0008877_abnormal_DNA_methylation0.70687634
168MP0003786_premature_aging0.69914078
169MP0006082_CNS_inflammation0.68162255
170MP0006036_abnormal_mitochondrial_physio0.67751387
171MP0005310_abnormal_salivary_gland0.67622665
172MP0001663_abnormal_digestive_system0.67498621
173MP0002075_abnormal_coat/hair_pigmentati0.66346800
174MP0000598_abnormal_liver_morphology0.65658581
175MP0010352_gastrointestinal_tract_polyps0.65316716
176MP0001929_abnormal_gametogenesis0.64671992
177MP0004147_increased_porphyrin_level0.58814795
178MP0002970_abnormal_white_adipose0.57868537
179MP0009764_decreased_sensitivity_to0.55992581
180MP0004510_myositis0.54625478
181MP0009931_abnormal_skin_appearance0.54163702
182MP0003567_abnormal_fetal_cardiomyocyte0.54128313
183MP0008873_increased_physiological_sensi0.51516233
184MP0003828_pulmonary_edema0.51367499
185MP0000350_abnormal_cell_proliferation0.50482141
186MP0000858_altered_metastatic_potential0.50277599
187MP0002080_prenatal_lethality0.50158505
188MP0000681_abnormal_thyroid_gland0.49767829
189MP0001879_abnormal_lymphatic_vessel0.46780938
190MP0002083_premature_death0.45736811
191MP0003868_abnormal_feces_composition0.44710311
192MP0002210_abnormal_sex_determination0.43603905

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)6.24660998
2Abnormality of cells of the erythroid lineage (HP:0012130)6.04839977
3Thrombocytosis (HP:0001894)5.99750043
4Abnormal number of erythroid precursors (HP:0012131)5.66162121
5Reticulocytopenia (HP:0001896)5.08691625
6Pancreatic cysts (HP:0001737)4.75021705
7IgM deficiency (HP:0002850)4.61525865
8Recurrent bronchitis (HP:0002837)4.53179611
9Nasal polyposis (HP:0100582)4.45891849
10Cellulitis (HP:0100658)4.39688801
11Pancreatic fibrosis (HP:0100732)4.33067730
12Elevated erythrocyte sedimentation rate (HP:0003565)4.31644946
13Abnormality of the nasal mucosa (HP:0000433)4.29147024
14Abnormality of midbrain morphology (HP:0002418)4.17253925
15Molar tooth sign on MRI (HP:0002419)4.17253925
16True hermaphroditism (HP:0010459)4.11159955
17Agammaglobulinemia (HP:0004432)4.00328270
18Myositis (HP:0100614)3.87959351
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.87499002
20Congenital stationary night blindness (HP:0007642)3.79768176
21Type II lissencephaly (HP:0007260)3.74412371
22Nephronophthisis (HP:0000090)3.72151893
23Aplastic anemia (HP:0001915)3.64737885
24Abnormality of T cell physiology (HP:0011840)3.63360625
25Chronic sinusitis (HP:0011109)3.54008391
26Panhypogammaglobulinemia (HP:0003139)3.50840864
27Eczematoid dermatitis (HP:0000976)3.50780015
28Pallor (HP:0000980)3.43218356
29Prolonged bleeding time (HP:0003010)3.40554697
30Meningitis (HP:0001287)3.40232034
31Recurrent viral infections (HP:0004429)3.39473362
32Macrocytic anemia (HP:0001972)3.39051076
33Abnormality of B cell number (HP:0010975)3.28177716
34B lymphocytopenia (HP:0010976)3.28177716
35Medial flaring of the eyebrow (HP:0010747)3.27448823
36Gastrointestinal inflammation (HP:0004386)3.16569879
37Poikiloderma (HP:0001029)3.12081947
38Abnormal drinking behavior (HP:0030082)3.09979845
39Polydipsia (HP:0001959)3.09979845
40Abnormality of the renal medulla (HP:0100957)3.08957103
41Thyroiditis (HP:0100646)3.08334451
42Spontaneous hematomas (HP:0007420)3.07538410
43Abnormality of T cells (HP:0002843)3.07055181
44Petechiae (HP:0000967)3.04943050
45Cutaneous melanoma (HP:0012056)2.99491963
46Inflammation of the large intestine (HP:0002037)2.93101108
47Tubular atrophy (HP:0000092)2.92809742
48Abnormality of the renal cortex (HP:0011035)2.91547805
49Recurrent abscess formation (HP:0002722)2.88722126
50Recurrent fungal infections (HP:0002841)2.88391344
51Cerebellar dysplasia (HP:0007033)2.87284852
52Epistaxis (HP:0000421)2.87005705
53Chronic hepatic failure (HP:0100626)2.86871462
54Cystic liver disease (HP:0006706)2.84842518
55Abnormal biliary tract physiology (HP:0012439)2.83402251
56Bile duct proliferation (HP:0001408)2.83402251
57Recurrent bacterial skin infections (HP:0005406)2.80737229
58Bronchitis (HP:0012387)2.76828193
59Pendular nystagmus (HP:0012043)2.72816098
60Interstitial pulmonary disease (HP:0006530)2.72538102
61Acute lymphatic leukemia (HP:0006721)2.71990491
62Acute necrotizing encephalopathy (HP:0006965)2.71450690
63Osteomyelitis (HP:0002754)2.65291317
64Verrucae (HP:0200043)2.64264228
65Papilloma (HP:0012740)2.64264228
66Anencephaly (HP:0002323)2.63439266
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62835092
68Gait imbalance (HP:0002141)2.61648884
69Sclerocornea (HP:0000647)2.61427056
70Abolished electroretinogram (ERG) (HP:0000550)2.61291327
71Decreased circulating renin level (HP:0003351)2.59825314
72Mitochondrial inheritance (HP:0001427)2.56976483
73Attenuation of retinal blood vessels (HP:0007843)2.56850812
74Lissencephaly (HP:0001339)2.50969019
75Congenital primary aphakia (HP:0007707)2.50913215
76Inability to walk (HP:0002540)2.49989711
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49590573
78Abnormality of alanine metabolism (HP:0010916)2.49590573
79Hyperalaninemia (HP:0003348)2.49590573
80Myelodysplasia (HP:0002863)2.48170923
81Impaired platelet aggregation (HP:0003540)2.47819622
82Abnormal platelet function (HP:0011869)2.47819622
83Entropion (HP:0000621)2.46922569
84Acute myeloid leukemia (HP:0004808)2.45249021
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.44498892
86Muscle fiber atrophy (HP:0100295)2.43957662
87Congenital, generalized hypertrichosis (HP:0004540)2.42480164
88Polyuria (HP:0000103)2.40682637
89Concave nail (HP:0001598)2.40393596
90Focal motor seizures (HP:0011153)2.40094624
91Lymphopenia (HP:0001888)2.39342376
92Colitis (HP:0002583)2.38196271
93Congenital hepatic fibrosis (HP:0002612)2.38042541
94Keratoconus (HP:0000563)2.37375470
95Increased corneal curvature (HP:0100692)2.37375470
96Lipid accumulation in hepatocytes (HP:0006561)2.36875945
97Progressive macrocephaly (HP:0004481)2.36698353
98Acute encephalopathy (HP:0006846)2.36695464
99Type 2 muscle fiber atrophy (HP:0003554)2.35855770
100Increased CSF lactate (HP:0002490)2.35751410
101Abnormal rod and cone electroretinograms (HP:0008323)2.35392285
102Recurrent skin infections (HP:0001581)2.35139494
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.33869598
104Increased IgE level (HP:0003212)2.31932705
105Asplenia (HP:0001746)2.30025413
106Reduced antithrombin III activity (HP:0001976)2.29981185
107Abnormality of the fingertips (HP:0001211)2.28843850
108Increased hepatocellular lipid droplets (HP:0006565)2.27202028
109Nephrogenic diabetes insipidus (HP:0009806)2.26925226
110Abnormal mitochondria in muscle tissue (HP:0008316)2.26315729
111Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25227925
112Amaurosis fugax (HP:0100576)2.24755287
1133-Methylglutaconic aciduria (HP:0003535)2.21718776
114Encephalitis (HP:0002383)2.20141103
115Gaze-evoked nystagmus (HP:0000640)2.19776980
116Recurrent cutaneous fungal infections (HP:0011370)2.19624195
117Chronic mucocutaneous candidiasis (HP:0002728)2.19624195
118IgG deficiency (HP:0004315)2.19544476
119Hypothermia (HP:0002045)2.18141116
120Chest pain (HP:0100749)2.17057988
121Long clavicles (HP:0000890)2.15844285
122Lymphoma (HP:0002665)2.14683193
12311 pairs of ribs (HP:0000878)2.14092350
124Optic nerve hypoplasia (HP:0000609)2.11177592
125Type I transferrin isoform profile (HP:0003642)2.10710048
126Hyperventilation (HP:0002883)2.10156322
127Decreased central vision (HP:0007663)2.10139762
128Microcytic anemia (HP:0001935)2.09973925
129Gingival bleeding (HP:0000225)2.09802382
130Furrowed tongue (HP:0000221)2.08924008
131Genital tract atresia (HP:0001827)2.07485500
132Abnormality of DNA repair (HP:0003254)2.06755728
133Occipital encephalocele (HP:0002085)2.06247258
134Vaginal atresia (HP:0000148)2.05669206
135Autoimmune thrombocytopenia (HP:0001973)2.04593343
136Arterial thrombosis (HP:0004420)2.04451517
137Male pseudohermaphroditism (HP:0000037)2.04194396
138Hypoproteinemia (HP:0003075)2.04031248
139Hepatocellular necrosis (HP:0001404)2.03520937
140Retinal dysplasia (HP:0007973)2.03477383
141Pancytopenia (HP:0001876)2.03393746
142Neutropenia (HP:0001875)2.01701418
143Aplasia/Hypoplasia of the spleen (HP:0010451)2.00663592
144Hypoplasia of the pons (HP:0012110)2.00514721
145T lymphocytopenia (HP:0005403)2.00485489
146Postaxial foot polydactyly (HP:0001830)2.00467969
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00228807
148Progressive inability to walk (HP:0002505)2.00156332
149Hepatic necrosis (HP:0002605)2.00131979
150Absent/shortened dynein arms (HP:0200106)1.97749248
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.97749248
152Abnormality of the pons (HP:0007361)1.96067004
153Large for gestational age (HP:0001520)1.95903584
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.95717348
155Pachygyria (HP:0001302)1.94545462
156Albinism (HP:0001022)1.94387764
157Hypoplasia of the thymus (HP:0000778)1.91746036
158Methylmalonic acidemia (HP:0002912)1.91727498
159Vasculitis (HP:0002633)1.90891477
160Skin rash (HP:0000988)1.90566800
161Renal cortical cysts (HP:0000803)1.89466349
162Sepsis (HP:0100806)1.88830543
163Erythema (HP:0010783)1.88768481
164Abnormal urine output (HP:0012590)1.88634924
165Optic disc pallor (HP:0000543)1.88355004
166Autoimmune hemolytic anemia (HP:0001890)1.87555626
167Hemiparesis (HP:0001269)1.86309447
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.85795722
169Basal cell carcinoma (HP:0002671)1.85627683
170Squamous cell carcinoma (HP:0002860)1.85589969
171Severe muscular hypotonia (HP:0006829)1.83939214
172Growth hormone excess (HP:0000845)1.83484094
173Recurrent sinusitis (HP:0011108)1.83268111
174Abnormality of T cell number (HP:0011839)1.82276031
175Obstructive lung disease (HP:0006536)1.81125653
176Chronic obstructive pulmonary disease (HP:0006510)1.81125653
177Colon cancer (HP:0003003)1.80369697
178Dialeptic seizures (HP:0011146)1.79499401
179Bony spicule pigmentary retinopathy (HP:0007737)1.79345345
180Septo-optic dysplasia (HP:0100842)1.78762508
181Abnormality of macrophages (HP:0004311)1.78562817
182Poor coordination (HP:0002370)1.77234193
183Broad-based gait (HP:0002136)1.76997651
184Hyperacusis (HP:0010780)1.76876647
185Mediastinal lymphadenopathy (HP:0100721)1.76376204
186IgA deficiency (HP:0002720)1.75925104
187Supernumerary spleens (HP:0009799)1.75689362
188Abnormality of reticulocytes (HP:0004312)1.74412965
189Abnormal respiratory epithelium morphology (HP:0012253)1.72406454
190Abnormal respiratory motile cilium morphology (HP:0005938)1.72406454
191Renal Fanconi syndrome (HP:0001994)1.72270029
192Increased serum lactate (HP:0002151)1.72027435
193Postaxial hand polydactyly (HP:0001162)1.71098916
194Hyperglycinuria (HP:0003108)1.70223085
195Abnormality of the ileum (HP:0001549)1.68667384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K6.12301758
2FRK4.41445936
3PKN23.96722360
4FLT33.34558229
5BMPR1B3.11775275
6WNK32.96345082
7MAP4K12.89108429
8PINK12.83200492
9GRK12.64101304
10ZAK2.52613051
11RPS6KB22.49446465
12KIT2.46729367
13WNK42.43550516
14BTK2.33350379
15CDK192.30859867
16MAP4K22.30733603
17MAPK152.18552242
18MAP3K102.14128067
19TGFBR12.06732663
20LRRK22.06718757
21TEC2.04684370
22NME22.01131638
23CSF1R1.96363274
24TRIB31.93296946
25TAOK31.83400782
26FES1.80686726
27SYK1.78350930
28MAPKAPK31.77954300
29MUSK1.67993123
30NUAK11.67970460
31OXSR11.65717524
32NEK21.63350012
33PASK1.59512976
34CASK1.56777882
35ZAP701.51379401
36DYRK21.47933628
37STK391.45019809
38GRK61.44704722
39WEE11.44220124
40TNIK1.43793060
41BLK1.41372935
42INSRR1.40749877
43ADRBK11.39951415
44ERN11.33672883
45STK38L1.32999019
46MAP2K31.32103502
47SIK21.31779570
48TBK11.30290198
49NME11.28759627
50MARK11.25767756
51NTRK21.25455984
52PIM21.24099380
53DAPK21.20735777
54CLK11.17206344
55TGFBR21.15380979
56PNCK1.13827726
57JAK31.13151219
58PAK31.11611706
59MAPKAPK51.11422030
60BCR1.08177981
61CAMKK21.06960896
62PIM11.05390267
63TAF11.03125965
64MAP3K41.02782830
65STK161.01908202
66PRKCG1.00112863
67LATS10.99595166
68MAPK110.97741475
69PLK20.97404100
70MAP2K70.94864326
71PLK30.94683237
72SCYL20.94411617
73RIPK40.93897728
74PLK40.93224849
75LYN0.92942125
76ADRBK20.91000308
77LCK0.90002990
78PRKCE0.89962523
79MKNK10.89955020
80IKBKE0.89903565
81TYK20.89243996
82PHKG10.88759511
83PHKG20.88759511
84IRAK40.87024700
85TRIM280.86771343
86VRK20.86476423
87STK100.85818449
88GRK70.85278658
89EPHA40.84994376
90CSNK1G20.83986107
91CDC70.82924292
92BRSK20.81834265
93HIPK20.81793591
94TNK20.80799113
95TIE10.80431999
96HCK0.80210102
97TXK0.78686476
98CDK40.77845967
99PIK3CA0.77366328
100DYRK30.76584997
101NLK0.76325698
102PTK2B0.74973931
103TSSK60.74340447
104MAPK40.73274572
105ERBB30.72746835
106MAPK120.70969464
107STK30.67970132
108PDK10.67863000
109NTRK30.67431657
110TRPM70.67058919
111IKBKB0.64941369
112TLK10.63375287
113MATK0.63337186
114CSNK1G30.63190314
115MST40.62649047
116CSNK1G10.62285590
117LIMK10.62141666
118CAMK2A0.61473275
119CSNK1A1L0.61187986
120MAP3K120.60818050
121ATR0.60717638
122MKNK20.59936593
123MAP3K70.58672209
124ILK0.57614697
125STK110.57429543
126ACVR1B0.56947197
127FGFR20.54932047
128ITK0.53981634
129VRK10.53894842
130CAMK10.53238525
131GRK50.50952775
132RPS6KB10.49140896
133PAK40.48879221
134PRKACA0.48268768
135OBSCN0.48174168
136PRKG20.47278397
137PAK20.45505451
138RAF10.44836794
139RPS6KA50.44617561
140CDK30.44441718
141STK40.44119066
142FGFR30.43838151
143PKN10.43278148
144MAP3K130.42905290
145EPHA30.42801038
146EPHB10.42629193
147RPS6KA60.42087813
148PRKCI0.41206378
149BCKDK0.40353980
150PRKCH0.40139941
151KDR0.40001753
152CDK60.38161370
153BUB10.38047148
154PLK10.37937931
155CCNB10.37518266
156PTK60.37465071
157CSNK1A10.37328836
158RPS6KL10.37281677
159RPS6KC10.37281677
160MAP3K80.37261116
161BRD40.36109848
162MAPK130.35994474
163JAK20.33976225
164CDK70.33458459
165FER0.32456672
166YES10.32305596
167MAP2K20.32243144
168PRKG10.31860945
169CDK80.31569917
170CAMK1D0.31553701
171MAP2K60.31418096
172SRPK10.30665226
173PRKCQ0.30489225
174MINK10.30149864
175CSNK1D0.29527096
176DYRK1A0.29244729

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.06413631
2DNA replication_Homo sapiens_hsa030304.00970404
3Primary immunodeficiency_Homo sapiens_hsa053403.58571209
4Oxidative phosphorylation_Homo sapiens_hsa001903.12455630
5Phototransduction_Homo sapiens_hsa047443.11602838
6Mismatch repair_Homo sapiens_hsa034302.72742870
7Base excision repair_Homo sapiens_hsa034102.54259826
8Parkinsons disease_Homo sapiens_hsa050122.51948457
9Non-homologous end-joining_Homo sapiens_hsa034502.50006630
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47218401
11B cell receptor signaling pathway_Homo sapiens_hsa046622.38721807
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37183363
13Linoleic acid metabolism_Homo sapiens_hsa005912.29733092
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25875062
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20853800
16Nitrogen metabolism_Homo sapiens_hsa009102.20561012
17Nicotine addiction_Homo sapiens_hsa050332.09176808
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04408553
19Butanoate metabolism_Homo sapiens_hsa006502.01475753
20Spliceosome_Homo sapiens_hsa030402.00591191
21Homologous recombination_Homo sapiens_hsa034401.88592047
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84638037
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83673753
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82210657
25Pyrimidine metabolism_Homo sapiens_hsa002401.77367294
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.75786954
27Cardiac muscle contraction_Homo sapiens_hsa042601.74835816
28Acute myeloid leukemia_Homo sapiens_hsa052211.73986735
29Huntingtons disease_Homo sapiens_hsa050161.73961522
30Taste transduction_Homo sapiens_hsa047421.71431676
31Nucleotide excision repair_Homo sapiens_hsa034201.68385481
32Alzheimers disease_Homo sapiens_hsa050101.62992144
33Measles_Homo sapiens_hsa051621.62758018
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59916344
35Morphine addiction_Homo sapiens_hsa050321.54699707
36Leishmaniasis_Homo sapiens_hsa051401.51897784
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51478762
38Tryptophan metabolism_Homo sapiens_hsa003801.50315778
39Antigen processing and presentation_Homo sapiens_hsa046121.48635906
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.47669678
41Pentose phosphate pathway_Homo sapiens_hsa000301.46389665
42Ether lipid metabolism_Homo sapiens_hsa005651.46082157
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45456646
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.44287246
45Herpes simplex infection_Homo sapiens_hsa051681.43182943
46N-Glycan biosynthesis_Homo sapiens_hsa005101.41850370
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39719939
48Hematopoietic cell lineage_Homo sapiens_hsa046401.36343153
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35425104
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35157692
51Propanoate metabolism_Homo sapiens_hsa006401.32235952
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29346659
53Olfactory transduction_Homo sapiens_hsa047401.25835238
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.25178463
55Caffeine metabolism_Homo sapiens_hsa002321.24057706
56Osteoclast differentiation_Homo sapiens_hsa043801.23340097
57Platelet activation_Homo sapiens_hsa046111.22997083
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21170870
59GABAergic synapse_Homo sapiens_hsa047271.17758541
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17196358
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15502346
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.14925643
63Systemic lupus erythematosus_Homo sapiens_hsa053221.13714757
64Cell cycle_Homo sapiens_hsa041101.12661027
65RNA degradation_Homo sapiens_hsa030181.10036068
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09860983
67Peroxisome_Homo sapiens_hsa041461.09000601
68beta-Alanine metabolism_Homo sapiens_hsa004101.07904712
69Sulfur relay system_Homo sapiens_hsa041221.07429624
70Shigellosis_Homo sapiens_hsa051311.07065220
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03174845
72Chronic myeloid leukemia_Homo sapiens_hsa052201.02291801
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99671546
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97376060
75ABC transporters_Homo sapiens_hsa020100.96304272
76Non-small cell lung cancer_Homo sapiens_hsa052230.96281198
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95905503
78Insulin secretion_Homo sapiens_hsa049110.95546361
79RNA transport_Homo sapiens_hsa030130.94598656
80Proteasome_Homo sapiens_hsa030500.92903765
81Hepatitis B_Homo sapiens_hsa051610.92731265
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.92472746
83Purine metabolism_Homo sapiens_hsa002300.91534319
84Retinol metabolism_Homo sapiens_hsa008300.91523636
85Chemical carcinogenesis_Homo sapiens_hsa052040.88829845
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88664163
87Histidine metabolism_Homo sapiens_hsa003400.88481467
88Protein export_Homo sapiens_hsa030600.87316448
89Arachidonic acid metabolism_Homo sapiens_hsa005900.86934988
90HIF-1 signaling pathway_Homo sapiens_hsa040660.86396676
91Influenza A_Homo sapiens_hsa051640.85491836
92Viral carcinogenesis_Homo sapiens_hsa052030.84979691
93RNA polymerase_Homo sapiens_hsa030200.84964953
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.83063602
95p53 signaling pathway_Homo sapiens_hsa041150.82388098
96One carbon pool by folate_Homo sapiens_hsa006700.81755539
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81285114
98Legionellosis_Homo sapiens_hsa051340.81281584
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.80444903
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79364910
101Glutamatergic synapse_Homo sapiens_hsa047240.79245184
102Regulation of autophagy_Homo sapiens_hsa041400.78611466
103T cell receptor signaling pathway_Homo sapiens_hsa046600.78167149
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78114557
105Serotonergic synapse_Homo sapiens_hsa047260.77969845
106Apoptosis_Homo sapiens_hsa042100.77492250
107Collecting duct acid secretion_Homo sapiens_hsa049660.77135895
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74924496
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72781600
110Toxoplasmosis_Homo sapiens_hsa051450.72699649
111Circadian entrainment_Homo sapiens_hsa047130.71811076
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71276874
113Thyroid cancer_Homo sapiens_hsa052160.70819716
114Epstein-Barr virus infection_Homo sapiens_hsa051690.70569801
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70246737
116Folate biosynthesis_Homo sapiens_hsa007900.68963666
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68788081
118Fanconi anemia pathway_Homo sapiens_hsa034600.68667053
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68532270
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.67822723
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67233625
122Other glycan degradation_Homo sapiens_hsa005110.66839664
123HTLV-I infection_Homo sapiens_hsa051660.66392987
124Metabolic pathways_Homo sapiens_hsa011000.66152675
125Ovarian steroidogenesis_Homo sapiens_hsa049130.64772710
126Selenocompound metabolism_Homo sapiens_hsa004500.63401723
127Salivary secretion_Homo sapiens_hsa049700.62837305
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61786730
129Vitamin digestion and absorption_Homo sapiens_hsa049770.61364589
130Fat digestion and absorption_Homo sapiens_hsa049750.60798962
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54989240
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.54697963
133Alcoholism_Homo sapiens_hsa050340.54565963
134Fatty acid degradation_Homo sapiens_hsa000710.53626540
135Calcium signaling pathway_Homo sapiens_hsa040200.53001447
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52110047
137Fatty acid elongation_Homo sapiens_hsa000620.51920983
138* Leukocyte transendothelial migration_Homo sapiens_hsa046700.51671018
139Mineral absorption_Homo sapiens_hsa049780.51024191
140VEGF signaling pathway_Homo sapiens_hsa043700.50586335
141Malaria_Homo sapiens_hsa051440.49227110
142Asthma_Homo sapiens_hsa053100.49180261
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.49032313
144Pertussis_Homo sapiens_hsa051330.48786648
145Hedgehog signaling pathway_Homo sapiens_hsa043400.48741063
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48349774
147Circadian rhythm_Homo sapiens_hsa047100.47906332
148Steroid biosynthesis_Homo sapiens_hsa001000.47616512
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47516697
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46981627
151Colorectal cancer_Homo sapiens_hsa052100.46336827
152Glycerolipid metabolism_Homo sapiens_hsa005610.45442707
153Galactose metabolism_Homo sapiens_hsa000520.44969998
154mRNA surveillance pathway_Homo sapiens_hsa030150.43955418
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43277221
156Pancreatic cancer_Homo sapiens_hsa052120.42934747
157Basal cell carcinoma_Homo sapiens_hsa052170.42719184
158Basal transcription factors_Homo sapiens_hsa030220.42621518
159Chemokine signaling pathway_Homo sapiens_hsa040620.42304104
160Cysteine and methionine metabolism_Homo sapiens_hsa002700.41708254
161Biosynthesis of amino acids_Homo sapiens_hsa012300.41644014
162Notch signaling pathway_Homo sapiens_hsa043300.40632256
163Prolactin signaling pathway_Homo sapiens_hsa049170.40462908
164Cyanoamino acid metabolism_Homo sapiens_hsa004600.39860411
165Pyruvate metabolism_Homo sapiens_hsa006200.39786958
166Salmonella infection_Homo sapiens_hsa051320.38801832
167Cocaine addiction_Homo sapiens_hsa050300.38161113
168Sphingolipid metabolism_Homo sapiens_hsa006000.37980055
169Tuberculosis_Homo sapiens_hsa051520.37922112
170Sulfur metabolism_Homo sapiens_hsa009200.37617275
171Fructose and mannose metabolism_Homo sapiens_hsa000510.37570509
172Hepatitis C_Homo sapiens_hsa051600.36296499
173Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35808598
174Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35732801
175Gastric acid secretion_Homo sapiens_hsa049710.35526746
176Arginine and proline metabolism_Homo sapiens_hsa003300.35389692

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