MYL12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.53615736
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.45883320
3cytidine metabolic process (GO:0046087)3.98905864
4cytidine catabolic process (GO:0006216)3.98905864
5cytidine deamination (GO:0009972)3.98905864
6wound healing, spreading of epidermal cells (GO:0035313)3.78868212
7sarcomere organization (GO:0045214)3.61628942
8immunoglobulin mediated immune response (GO:0016064)3.61161145
9actin-myosin filament sliding (GO:0033275)3.50317288
10muscle filament sliding (GO:0030049)3.50317288
11pyrimidine ribonucleoside catabolic process (GO:0046133)3.47322072
12antigen processing and presentation via MHC class Ib (GO:0002475)3.41728824
13viral transcription (GO:0019083)3.35040171
14B cell mediated immunity (GO:0019724)3.29401468
15wound healing, spreading of cells (GO:0044319)3.28836241
16translational termination (GO:0006415)3.24826381
17regulation of B cell receptor signaling pathway (GO:0050855)3.24523546
18positive regulation of interleukin-8 secretion (GO:2000484)3.23552621
19positive regulation of gamma-delta T cell activation (GO:0046645)3.22939981
20negative regulation of cell killing (GO:0031342)3.18911574
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18911574
22antigen processing and presentation of endogenous antigen (GO:0019883)3.16700234
23antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15070741
24cell adhesion mediated by integrin (GO:0033627)3.14961313
25negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.14449398
26plasma membrane repair (GO:0001778)3.14354621
27endodermal cell differentiation (GO:0035987)3.08576199
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08486129
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06922850
30regulation of T cell tolerance induction (GO:0002664)3.06874804
31actin nucleation (GO:0045010)3.06618197
32skin morphogenesis (GO:0043589)3.04685673
33neutrophil activation (GO:0042119)3.02114282
34chondrocyte proliferation (GO:0035988)3.01138757
35actin-mediated cell contraction (GO:0070252)3.00866312
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00809987
37positive regulation of lamellipodium assembly (GO:0010592)3.00239565
38desmosome organization (GO:0002934)3.00116620
39epithelial cell-cell adhesion (GO:0090136)2.98992587
40response to interferon-beta (GO:0035456)2.97922350
41positive regulation of endothelial cell apoptotic process (GO:2000353)2.95997705
42ribosomal small subunit assembly (GO:0000028)2.94086858
43vascular endothelial growth factor signaling pathway (GO:0038084)2.93701374
44granulocyte activation (GO:0036230)2.89710719
45membrane raft organization (GO:0031579)2.87654474
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.84669382
47translational elongation (GO:0006414)2.84563819
48T cell costimulation (GO:0031295)2.84290135
49ribosomal small subunit biogenesis (GO:0042274)2.84084944
50basement membrane organization (GO:0071711)2.83533876
51regulation of metalloenzyme activity (GO:0048552)2.80988519
52lymphocyte costimulation (GO:0031294)2.80564794
53regulation of tight junction assembly (GO:2000810)2.79403555
54regulation of tolerance induction (GO:0002643)2.78835014
55positive regulation of monocyte chemotaxis (GO:0090026)2.78691359
56protein targeting to ER (GO:0045047)2.77493990
57regulation of regulatory T cell differentiation (GO:0045589)2.77438208
58negative regulation of T cell apoptotic process (GO:0070233)2.74817766
59regulation of integrin-mediated signaling pathway (GO:2001044)2.73106705
60cotranslational protein targeting to membrane (GO:0006613)2.72858152
61hemidesmosome assembly (GO:0031581)2.72598671
62collagen fibril organization (GO:0030199)2.72575467
63morphogenesis of an endothelium (GO:0003159)2.71871297
64endothelial tube morphogenesis (GO:0061154)2.71871297
65negative T cell selection (GO:0043383)2.71292400
66heart process (GO:0003015)2.70894724
67heart contraction (GO:0060047)2.70894724
68positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70291236
69antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.69739320
70pyrimidine nucleoside catabolic process (GO:0046135)2.69680020
71atrioventricular valve morphogenesis (GO:0003181)2.67825048
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66705912
73T cell migration (GO:0072678)2.65302193
74regulation of alpha-beta T cell proliferation (GO:0046640)2.65144224
75protein neddylation (GO:0045116)2.64698909
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64392927
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64141767
78viral life cycle (GO:0019058)2.62185153
79interferon-gamma-mediated signaling pathway (GO:0060333)2.60853935
80ventricular cardiac muscle cell development (GO:0055015)2.59814161
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59412506
82regulation of T cell mediated cytotoxicity (GO:0001914)2.57703484
83positive thymic T cell selection (GO:0045059)2.57594800
84protein heterotrimerization (GO:0070208)2.57560780
85positive regulation of tolerance induction (GO:0002645)2.57021912
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.56661972
87positive regulation of B cell differentiation (GO:0045579)2.54114897
88protein localization to endoplasmic reticulum (GO:0070972)2.54020252
89translational initiation (GO:0006413)2.53968654
90mast cell activation (GO:0045576)2.53921137
91cellular response to interferon-alpha (GO:0035457)2.53814358
92cellular response to type I interferon (GO:0071357)2.53589343
93type I interferon signaling pathway (GO:0060337)2.53589343
94maturation of SSU-rRNA (GO:0030490)2.53053321
95cardiac myofibril assembly (GO:0055003)2.52367648
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.51618285
97pinocytosis (GO:0006907)2.51473710
98proteasome assembly (GO:0043248)2.51382872
99dendritic cell chemotaxis (GO:0002407)2.48577577
100regulation of SMAD protein import into nucleus (GO:0060390)2.47852778
101sequestering of actin monomers (GO:0042989)2.47599919
102regulation of cellular amino acid metabolic process (GO:0006521)2.47387666
103positive regulation of mast cell activation (GO:0033005)2.47349653
104response to type I interferon (GO:0034340)2.47138339
105dendritic cell migration (GO:0036336)2.45978463
106negative thymic T cell selection (GO:0045060)2.45967890
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.44806301
108positive regulation of epithelial to mesenchymal transition (GO:0010718)2.44690031
109glomerular basement membrane development (GO:0032836)2.44430271
110endothelial cell morphogenesis (GO:0001886)2.44290086
111cellular protein complex disassembly (GO:0043624)2.44243880
112T cell receptor signaling pathway (GO:0050852)2.43567917
113lymphocyte chemotaxis (GO:0048247)2.43123263
114leukocyte degranulation (GO:0043299)2.43101219
115DNA deamination (GO:0045006)2.42884649
116positive regulation of macrophage differentiation (GO:0045651)2.42577962
117negative regulation of stress fiber assembly (GO:0051497)2.42161844
118cell-substrate junction assembly (GO:0007044)2.40528922
119regulation of skeletal muscle contraction (GO:0014819)2.39559693
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.39451063
121regulation of protein heterodimerization activity (GO:0043497)2.38825988
122cellular response to interleukin-15 (GO:0071350)2.37795313
123positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37749426
124positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.37702320
125myeloid cell activation involved in immune response (GO:0002275)2.37595153
126leukocyte aggregation (GO:0070486)2.37402844
127glomerular visceral epithelial cell development (GO:0072015)2.37192538
128regulation of hypersensitivity (GO:0002883)2.36130590
129lymph vessel development (GO:0001945)2.35380421
130regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35072004
131Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34433129
132angiogenesis involved in wound healing (GO:0060055)2.34261602
133positive regulation of natural killer cell differentiation (GO:0032825)2.34125854
134apoptotic process involved in morphogenesis (GO:0060561)2.33550958
135T cell apoptotic process (GO:0070231)2.33294051
136skeletal muscle contraction (GO:0003009)2.32776838
137antigen receptor-mediated signaling pathway (GO:0050851)2.32698587
138response to interferon-alpha (GO:0035455)2.32683266
139actomyosin structure organization (GO:0031032)2.30984883
140actin filament-based movement (GO:0030048)2.30960921
141phagocytosis, engulfment (GO:0006911)2.30391299
142regulation of B cell differentiation (GO:0045577)2.29499751
143mesodermal cell differentiation (GO:0048333)2.28848747
144regulation of leukocyte mediated cytotoxicity (GO:0001910)2.27831792
145positive regulation of immunoglobulin mediated immune response (GO:0002891)2.27698776
146positive regulation of B cell mediated immunity (GO:0002714)2.27698776
147bundle of His cell to Purkinje myocyte communication (GO:0086069)2.27661204
148substrate adhesion-dependent cell spreading (GO:0034446)2.27523917
149formation of translation preinitiation complex (GO:0001731)2.26973138
150response to peptidoglycan (GO:0032494)2.26790338
151response to interleukin-15 (GO:0070672)2.26273363
152detection of other organism (GO:0098543)2.26110298
153G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.25921815
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.25887781
155negative regulation of nitric-oxide synthase activity (GO:0051001)2.25395896
156negative regulation of leukocyte apoptotic process (GO:2000107)2.24873556
157cell migration involved in sprouting angiogenesis (GO:0002042)2.24556132
158cell migration involved in heart development (GO:0060973)2.23818102
159positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.20045463
160lymphangiogenesis (GO:0001946)2.19935492
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.19792608
162establishment of endothelial barrier (GO:0061028)2.19417140
163cardiac muscle cell development (GO:0055013)2.18762517
164myofibril assembly (GO:0030239)2.18379139
165cardiac cell development (GO:0055006)2.18249223
166negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.16858185
167vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.16384051
168blood vessel endothelial cell migration (GO:0043534)2.16232267
169apoptotic cell clearance (GO:0043277)2.15250855
170regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.14423583
171retina vasculature morphogenesis in camera-type eye (GO:0061299)2.14291457
172ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.11875004
173substrate-dependent cell migration (GO:0006929)2.11695212
174hippo signaling (GO:0035329)2.11660273
175fibroblast migration (GO:0010761)2.11191771
176cardiac muscle tissue morphogenesis (GO:0055008)2.10534857
177regulation of interleukin-8 secretion (GO:2000482)2.07838153
178ribosomal large subunit biogenesis (GO:0042273)2.07313112
179mRNA transcription (GO:0009299)2.06895706
180regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.05001774
181trabecula morphogenesis (GO:0061383)2.04099274
182branching involved in salivary gland morphogenesis (GO:0060445)2.03805509
183peptidyl-proline hydroxylation (GO:0019511)2.03761742
184positive regulation of SMAD protein import into nucleus (GO:0060391)2.03077907
185glomerular epithelial cell development (GO:0072310)2.02597101
186positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.02541931
187myeloid cell homeostasis (GO:0002262)2.02025732
188positive regulation of actin filament depolymerization (GO:0030836)2.01936610
189protein complex disassembly (GO:0043241)2.01895955
190heart trabecula formation (GO:0060347)2.00837197
191response to laminar fluid shear stress (GO:0034616)1.99811208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.85215313
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.62756551
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.48209507
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.46913283
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34414506
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.70945060
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65053824
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64364157
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.56112643
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44482221
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38862059
12E2F7_22180533_ChIP-Seq_HELA_Human2.38804097
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35171002
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.31968139
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29623143
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25449593
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.25016198
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24635014
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23072303
20CLOCK_20551151_ChIP-Seq_293T_Human2.19228434
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18973729
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13102484
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05690623
24RUNX_20019798_ChIP-Seq_JUKART_Human2.05409931
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02678014
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01534220
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99262928
28* GATA2_21666600_ChIP-Seq_HMVEC_Human1.94344340
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92684171
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89781360
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.89102612
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86554924
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.82306765
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.80909413
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75456724
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75456724
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70624601
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.66215353
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62477956
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61459805
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58142844
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.56655865
43SPI1_23127762_ChIP-Seq_K562_Human1.55970125
44* MYB_26560356_Chip-Seq_TH1_Human1.55287203
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53644332
46ATF3_27146783_Chip-Seq_COLON_Human1.53504427
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52739591
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48180280
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47536316
50GATA3_26560356_Chip-Seq_TH2_Human1.47242294
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46958982
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46028051
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.45708434
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45609240
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44723062
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.43576364
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43510924
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43174489
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39992863
60GATA3_27048872_Chip-Seq_THYMUS_Human1.39559473
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39490172
62AR_21909140_ChIP-Seq_LNCAP_Human1.37851942
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34791022
64ELK1_19687146_ChIP-ChIP_HELA_Human1.34407182
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33986993
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.31432520
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30191948
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.27976272
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.27480518
70XRN2_22483619_ChIP-Seq_HELA_Human1.26857218
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26575780
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26287075
73MAF_26560356_Chip-Seq_TH1_Human1.25747259
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25569907
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24976678
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24071640
77CJUN_26792858_Chip-Seq_BT549_Human1.20317708
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20008592
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18534350
80BRD4_25478319_ChIP-Seq_HGPS_Human1.18463661
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18217990
82DCP1A_22483619_ChIP-Seq_HELA_Human1.18151257
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17890277
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17111140
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.17048332
86MYC_22102868_ChIP-Seq_BL_Human1.17034585
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16944868
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16773912
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14317394
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13924982
91RACK7_27058665_Chip-Seq_MCF-7_Human1.13834009
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13476225
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12202932
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11587522
95VDR_21846776_ChIP-Seq_THP-1_Human1.11558028
96VDR_24787735_ChIP-Seq_THP-1_Human1.11543750
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11495115
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11481711
99* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10927848
100VDR_24763502_ChIP-Seq_THP-1_Human1.10669388
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10413735
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09678559
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08755664
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.08733351
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.08733351
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08417951
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07803661
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07740684
109* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07564427
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.07231775
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07152616
112SCL_19346495_ChIP-Seq_HPC-7_Human1.07017290
113ZNF263_19887448_ChIP-Seq_K562_Human1.06998443
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06539392
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06323934
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06123270
117* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05049203
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02892683
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02774267
120SPI1_23547873_ChIP-Seq_NB4_Human1.02684869
121GATA1_22025678_ChIP-Seq_K562_Human1.01908644
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01588297
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01449350
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00959061
125UTX_26944678_Chip-Seq_JUKART_Human1.00549382
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00329615
127* TFEB_21752829_ChIP-Seq_HELA_Human0.99849452
128ETS1_20019798_ChIP-Seq_JURKAT_Human0.99655032
129MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99075118
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98555286
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98196402
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97972928
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97609123
134SRF_21415370_ChIP-Seq_HL-1_Mouse0.95690392
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95187816
136SOX2_20726797_ChIP-Seq_SW620_Human0.95016871
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94731334
138PU_27001747_Chip-Seq_BMDM_Mouse0.94068140
139GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93624983
140* MYB_26560356_Chip-Seq_TH2_Human0.92308344
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92235932
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91937434
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.91856567
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91195648
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91155891
146E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91140803
147PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90757030
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89917516
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.89889982
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89694188
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.88055482
152RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86538108
153PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86381834
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.84673044
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84111231
156* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84081003
157STAT1_20625510_ChIP-Seq_HELA_Human0.81522603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.06513694
2MP0005671_abnormal_response_to3.10961066
3MP0005275_abnormal_skin_tensile2.95915874
4MP0003705_abnormal_hypodermis_morpholog2.93252961
5MP0005464_abnormal_platelet_physiology2.74364098
6MP0003279_aneurysm2.71245199
7MP0003566_abnormal_cell_adhesion2.48184440
8MP0005000_abnormal_immune_tolerance2.27394675
9MP0004272_abnormal_basement_membrane2.20744269
10MP0004084_abnormal_cardiac_muscle2.19816563
11MP0006082_CNS_inflammation2.14745724
12MP0003806_abnormal_nucleotide_metabolis2.14384535
13MP0005503_abnormal_tendon_morphology2.07943344
14MP0001800_abnormal_humoral_immune2.01339976
15MP0001958_emphysema2.00557463
16MP0005025_abnormal_response_to1.99190532
17MP0010368_abnormal_lymphatic_system1.96078730
18MP0006054_spinal_hemorrhage1.95865496
19MP0010352_gastrointestinal_tract_polyps1.94860451
20MP0002419_abnormal_innate_immunity1.93074289
21MP0000750_abnormal_muscle_regeneration1.92176173
22MP0003763_abnormal_thymus_physiology1.91232595
23MP0005623_abnormal_meninges_morphology1.90056454
24MP0005387_immune_system_phenotype1.87390539
25MP0001790_abnormal_immune_system1.87390539
26MP0002452_abnormal_antigen_presenting1.86515908
27MP0002723_abnormal_immune_serum1.85664054
28MP0005023_abnormal_wound_healing1.84850973
29MP0001879_abnormal_lymphatic_vessel1.79039407
30MP0010155_abnormal_intestine_physiology1.74145037
31MP0003191_abnormal_cellular_cholesterol1.73891767
32MP0002420_abnormal_adaptive_immunity1.73559253
33MP0001819_abnormal_immune_cell1.72230285
34MP0003828_pulmonary_edema1.68167815
35MP0003941_abnormal_skin_development1.67572080
36MP0000749_muscle_degeneration1.61729643
37MP0010030_abnormal_orbit_morphology1.57873886
38MP0009384_cardiac_valve_regurgitation1.51887700
39MP0000465_gastrointestinal_hemorrhage1.51397278
40MP0000733_abnormal_muscle_development1.48407537
41MP0000858_altered_metastatic_potential1.47852777
42MP0001845_abnormal_inflammatory_respons1.47133917
43MP0000767_abnormal_smooth_muscle1.45390233
44MP0008004_abnormal_stomach_pH1.44378156
45MP0003091_abnormal_cell_migration1.43396451
46MP0005330_cardiomyopathy1.41846487
47MP0003646_muscle_fatigue1.40923865
48MP0002060_abnormal_skin_morphology1.40226698
49MP0000343_altered_response_to1.36266562
50MP0009764_decreased_sensitivity_to1.35830621
51MP0002332_abnormal_exercise_endurance1.33800908
52MP0004087_abnormal_muscle_fiber1.31651973
53MP0002398_abnormal_bone_marrow1.30937314
54MP0002877_abnormal_melanocyte_morpholog1.30506980
55MP0005451_abnormal_body_composition1.28879936
56MP0000716_abnormal_immune_system1.27548304
57MP0010630_abnormal_cardiac_muscle1.25555360
58MP0003950_abnormal_plasma_membrane1.24080686
59MP0005166_decreased_susceptibility_to1.23613791
60MP0001873_stomach_inflammation1.23545873
61MP0003724_increased_susceptibility_to1.22502105
62MP0001542_abnormal_bone_strength1.22363764
63MP0003866_abnormal_defecation1.22038051
64MP0004145_abnormal_muscle_electrophysio1.21230764
65MP0008469_abnormal_protein_level1.20029657
66MP0005508_abnormal_skeleton_morphology1.19687650
67MP0002837_dystrophic_cardiac_calcinosis1.16639754
68MP0008775_abnormal_heart_ventricle1.15426104
69MP0003436_decreased_susceptibility_to1.15204065
70MP0005385_cardiovascular_system_phenoty1.14175839
71MP0001544_abnormal_cardiovascular_syste1.14175839
72MP0002933_joint_inflammation1.11715053
73MP0002972_abnormal_cardiac_muscle1.11577384
74MP0003448_altered_tumor_morphology1.11421495
75MP0003075_altered_response_to1.10358766
76MP0009763_increased_sensitivity_to1.09934158
77MP0004484_altered_response_of1.09564876
78MP0006036_abnormal_mitochondrial_physio1.09122950
79MP0002295_abnormal_pulmonary_circulatio1.08420067
80MP0002429_abnormal_blood_cell1.08076815
81MP0006138_congestive_heart_failure1.07464567
82MP0001243_abnormal_dermal_layer1.07054035
83MP0002132_abnormal_respiratory_system1.06232533
84MP0000685_abnormal_immune_system1.05824310
85MP0000689_abnormal_spleen_morphology1.04852980
86MP0008007_abnormal_cellular_replicative1.03926998
87MP0004036_abnormal_muscle_relaxation1.03577397
88MP0005058_abnormal_lysosome_morphology1.02901254
89MP0001533_abnormal_skeleton_physiology1.02693650
90MP0000751_myopathy1.02608558
91MP0002722_abnormal_immune_system1.01897385
92MP0001853_heart_inflammation1.01230499
93MP0005390_skeleton_phenotype1.00407521
94MP0005164_abnormal_response_to1.00346406
95MP0004883_abnormal_blood_vessel0.99496653
96MP0003453_abnormal_keratinocyte_physiol0.99265959
97MP0009785_altered_susceptibility_to0.98906804
98MP0002998_abnormal_bone_remodeling0.98782062
99MP0003045_fibrosis0.98708713
100MP0005076_abnormal_cell_differentiation0.98117651
101MP0002128_abnormal_blood_circulation0.96461933
102MP0009053_abnormal_anal_canal0.95880097
103MP0004957_abnormal_blastocyst_morpholog0.95188461
104MP0004808_abnormal_hematopoietic_stem0.95069635
105MP0009333_abnormal_splenocyte_physiolog0.93437542
106MP0002166_altered_tumor_susceptibility0.93390516
107MP0000759_abnormal_skeletal_muscle0.91268112
108MP0003300_gastrointestinal_ulcer0.89458845
109MP0004947_skin_inflammation0.88874423
110MP0002148_abnormal_hypersensitivity_rea0.88851500
111MP0001851_eye_inflammation0.87988052
112MP0001614_abnormal_blood_vessel0.87260914
113MP0000747_muscle_weakness0.87209133
114MP0004510_myositis0.85937770
115MP0001835_abnormal_antigen_presentation0.85467624
116MP0009278_abnormal_bone_marrow0.84697120
117MP0003567_abnormal_fetal_cardiomyocyte0.83882627
118MP0005620_abnormal_muscle_contractility0.83517007
119MP0005501_abnormal_skin_physiology0.82935576
120MP0002925_abnormal_cardiovascular_devel0.82304950
121MP0005165_increased_susceptibility_to0.82162569
122MP0002405_respiratory_system_inflammati0.82030889
123MP0005360_urolithiasis0.81354532
124MP0002006_tumorigenesis0.81072333
125MP0002106_abnormal_muscle_physiology0.79628656
126MP0005257_abnormal_intraocular_pressure0.79541094
127MP0003186_abnormal_redox_activity0.79127020
128MP0002796_impaired_skin_barrier0.78428575
129MP0003303_peritoneal_inflammation0.78427261
130MP0003385_abnormal_body_wall0.77749574
131MP0009379_abnormal_foot_pigmentation0.77258763
132MP0002282_abnormal_trachea_morphology0.76717589
133MP0004215_abnormal_myocardial_fiber0.76665923
134MP0001915_intracranial_hemorrhage0.76194261
135MP0002269_muscular_atrophy0.75659031
136MP0000249_abnormal_blood_vessel0.75444579
137MP0001545_abnormal_hematopoietic_system0.74818486
138MP0005397_hematopoietic_system_phenotyp0.74818486
139MP0002396_abnormal_hematopoietic_system0.74423805
140MP0009250_abnormal_appendicular_skeleto0.73334441
141MP0000266_abnormal_heart_morphology0.72344648
142MP0005369_muscle_phenotype0.71799298
143MP0003693_abnormal_embryo_hatching0.71518486
144MP0000762_abnormal_tongue_morphology0.71014563
145MP0003984_embryonic_growth_retardation0.69953514
146MP0003221_abnormal_cardiomyocyte_apopto0.69820774
147MP0001216_abnormal_epidermal_layer0.69574641

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.46187203
2Premature rupture of membranes (HP:0001788)5.43925190
3Increased connective tissue (HP:0009025)3.88101912
4Right ventricular cardiomyopathy (HP:0011663)3.56918320
5Aortic aneurysm (HP:0004942)3.47701501
6Ventricular tachycardia (HP:0004756)3.40189419
7Aortic dissection (HP:0002647)3.30819323
8Petechiae (HP:0000967)3.29709029
9Muscle fiber splitting (HP:0003555)3.24082973
10Type 1 muscle fiber predominance (HP:0003803)3.22900699
11Distal lower limb muscle weakness (HP:0009053)3.22754993
12Atrophic scars (HP:0001075)3.13227517
13Cerebral aneurysm (HP:0004944)3.06996877
14Abnormality of macrophages (HP:0004311)3.06290605
15Vertebral compression fractures (HP:0002953)3.05510755
16Abnormality of T cell number (HP:0011839)3.03365177
17Prolonged bleeding time (HP:0003010)3.02389992
18Increased IgM level (HP:0003496)3.00682137
19T lymphocytopenia (HP:0005403)3.00615396
20Spinal rigidity (HP:0003306)2.98262061
21Ankle contracture (HP:0006466)2.91633674
22Soft skin (HP:0000977)2.88601173
23Hyporeflexia of lower limbs (HP:0002600)2.85946473
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.84777588
25Dilatation of the ascending aorta (HP:0005111)2.81647601
26Autoimmune hemolytic anemia (HP:0001890)2.80131389
27Epistaxis (HP:0000421)2.78102657
28Peritonitis (HP:0002586)2.78033430
29Lipoatrophy (HP:0100578)2.77931139
30Exercise-induced myalgia (HP:0003738)2.77633858
31Muscle fiber inclusion bodies (HP:0100299)2.74720902
32Osteolytic defects of the hand bones (HP:0009699)2.71737377
33Osteolytic defects of the phalanges of the hand (HP:0009771)2.71737377
34Shallow orbits (HP:0000586)2.69364611
35Recurrent abscess formation (HP:0002722)2.69283827
36Difficulty climbing stairs (HP:0003551)2.64921169
37Aplastic anemia (HP:0001915)2.61678672
38Purpura (HP:0000979)2.61476348
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.60423997
40Wormian bones (HP:0002645)2.57872144
41Cervical subluxation (HP:0003308)2.56162110
42Fragile skin (HP:0001030)2.55002656
43Nemaline bodies (HP:0003798)2.52488673
44Myositis (HP:0100614)2.51073422
45Palpitations (HP:0001962)2.46498734
46Abnormal platelet volume (HP:0011876)2.46139615
47Menorrhagia (HP:0000132)2.45003254
48Stomatitis (HP:0010280)2.43939966
49Sudden death (HP:0001699)2.43615117
50Obstructive lung disease (HP:0006536)2.43555084
51Chronic obstructive pulmonary disease (HP:0006510)2.43555084
52Trismus (HP:0000211)2.39931317
53IgG deficiency (HP:0004315)2.39687375
54Recurrent bacterial skin infections (HP:0005406)2.38231182
55Increased mean platelet volume (HP:0011877)2.36292910
56Asymmetric septal hypertrophy (HP:0001670)2.34938830
57Gingival bleeding (HP:0000225)2.34633296
58Short nail (HP:0001799)2.32059551
59Spontaneous hematomas (HP:0007420)2.28738837
60EMG: myopathic abnormalities (HP:0003458)2.28369629
61Abnormality of T cells (HP:0002843)2.27586185
62Abnormality of placental membranes (HP:0011409)2.27481100
63Amniotic constriction ring (HP:0009775)2.27481100
64Abnormality of the calf musculature (HP:0001430)2.26011937
65Exercise-induced muscle cramps (HP:0003710)2.25864868
66Round ear (HP:0100830)2.25777965
67Biconcave vertebral bodies (HP:0004586)2.22714294
68Blue sclerae (HP:0000592)2.22046986
69Hypoproteinemia (HP:0003075)2.21628620
70Pulmonary infiltrates (HP:0002113)2.21037974
71Scapular winging (HP:0003691)2.20853099
72Abnormality of dentin (HP:0010299)2.20436673
73Increased density of long bones (HP:0006392)2.18884054
74Abnormal hemoglobin (HP:0011902)2.16472714
75Vascular tortuosity (HP:0004948)2.15648862
76Mildly elevated creatine phosphokinase (HP:0008180)2.15215319
77Facial diplegia (HP:0001349)2.13797417
78Abnormality of skeletal muscle fiber size (HP:0012084)2.12603056
79Eosinophilia (HP:0001880)2.11076733
80Abnormality of the calcaneus (HP:0008364)2.10576027
81Chest pain (HP:0100749)2.10555017
82Spondylolisthesis (HP:0003302)2.09790209
83Distal lower limb amyotrophy (HP:0008944)2.09135664
84Myoglobinuria (HP:0002913)2.08806537
85Distal arthrogryposis (HP:0005684)2.06298189
86Bundle branch block (HP:0011710)2.05491838
87Recurrent gram-negative bacterial infections (HP:0005420)2.05187993
88Bladder diverticulum (HP:0000015)2.05117677
89Increased intramyocellular lipid droplets (HP:0012240)2.05052847
90Broad metatarsal (HP:0001783)2.04628248
91Vasculitis (HP:0002633)2.04395315
92Meningitis (HP:0001287)2.04198754
93Orchitis (HP:0100796)2.03992918
94Muscle hypertrophy of the lower extremities (HP:0008968)2.03465066
95Mesangial abnormality (HP:0001966)2.02475922
96Dilated cardiomyopathy (HP:0001644)2.02386798
97Limb-girdle muscle atrophy (HP:0003797)2.02184561
98Recurrent fungal infections (HP:0002841)1.99941137
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.99537639
100Granulocytopenia (HP:0001913)1.99341762
101Hepatosplenomegaly (HP:0001433)1.98311666
102Weak cry (HP:0001612)1.97276419
103Abnormality of the umbilical cord (HP:0010881)1.96195883
104Aneurysm (HP:0002617)1.95631096
105Retrobulbar optic neuritis (HP:0100654)1.95398306
106Optic neuritis (HP:0100653)1.95398306
107Hypergammaglobulinemia (HP:0010702)1.94892980
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93621538
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93621538
110Neonatal short-limb short stature (HP:0008921)1.93529836
111Nonimmune hydrops fetalis (HP:0001790)1.93410464
112Bulbar palsy (HP:0001283)1.93102625
113Calcaneovalgus deformity (HP:0001848)1.92534908
114Chronic diarrhea (HP:0002028)1.91451385
115Multiple enchondromatosis (HP:0005701)1.90971254
116Increased variability in muscle fiber diameter (HP:0003557)1.90803434
117Atrial fibrillation (HP:0005110)1.90709207
118Chronic mucocutaneous candidiasis (HP:0002728)1.90169203
119Recurrent cutaneous fungal infections (HP:0011370)1.90169203
120Wrist flexion contracture (HP:0001239)1.89983295
121Congenital, generalized hypertrichosis (HP:0004540)1.88736131
122Elbow flexion contracture (HP:0002987)1.88455652
123Encephalitis (HP:0002383)1.87361955
124Hemoptysis (HP:0002105)1.87360147
125Pustule (HP:0200039)1.87304788
126Mitral regurgitation (HP:0001653)1.85866686
127Gastrointestinal infarctions (HP:0005244)1.85804534
128Impaired platelet aggregation (HP:0003540)1.85506500
129Abnormal platelet function (HP:0011869)1.85506500
130Recurrent skin infections (HP:0001581)1.85505543
131Supraventricular arrhythmia (HP:0005115)1.85224287
132Abnormality of the prostate (HP:0008775)1.85207205
133Increased muscle lipid content (HP:0009058)1.83937879
134Selective tooth agenesis (HP:0001592)1.83932959
135Abnormality of the left ventricular outflow tract (HP:0011103)1.83334552
136Subaortic stenosis (HP:0001682)1.83334552
137Calf muscle hypertrophy (HP:0008981)1.83105935
138Abnormality of T cell physiology (HP:0011840)1.82773106
139Type 2 muscle fiber atrophy (HP:0003554)1.82464087
140Joint swelling (HP:0001386)1.82018385
141Pulmonary artery stenosis (HP:0004415)1.81950196
142Deformed tarsal bones (HP:0008119)1.81727225
143Pterygium (HP:0001059)1.81177157
144Generalized amyotrophy (HP:0003700)1.80739387
145Abnormality of the distal phalanges of the toes (HP:0010182)1.80690195
146Arterial thrombosis (HP:0004420)1.80418607
147Mitochondrial inheritance (HP:0001427)1.79700866
148Primary atrial arrhythmia (HP:0001692)1.78985832
149Supraventricular tachycardia (HP:0004755)1.78059456
150Reduced subcutaneous adipose tissue (HP:0003758)1.77335934
151Hematochezia (HP:0002573)1.76809539
152Neck muscle weakness (HP:0000467)1.76424058
153Abnormality of the acetabulum (HP:0003170)1.75516062
154Abnormal delivery (HP:0001787)1.75369257
155Ulnar deviation of the wrist (HP:0003049)1.75062648
156Mitral valve prolapse (HP:0001634)1.72890124
157Natal tooth (HP:0000695)1.71880569
158Fused cervical vertebrae (HP:0002949)1.70735035
159Camptodactyly of toe (HP:0001836)1.67667721
160Spinal cord lesions (HP:0100561)1.67351468
161Syringomyelia (HP:0003396)1.67351468
162Elevated erythrocyte sedimentation rate (HP:0003565)1.63435890
163Genu recurvatum (HP:0002816)1.63284094
164Radial bowing (HP:0002986)1.62248306
165Breech presentation (HP:0001623)1.60873827
166Rhabdomyolysis (HP:0003201)1.60051436
167Areflexia of lower limbs (HP:0002522)1.59759911
168Eczematoid dermatitis (HP:0000976)1.59417983
169Reticulocytopenia (HP:0001896)1.58052972
170Bicuspid aortic valve (HP:0001647)1.57411044
171Abnormality of the peritoneum (HP:0002585)1.57095643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.93730267
2TTN3.75957590
3TXK3.07935502
4NME23.06941143
5TESK12.65723495
6TRIB32.62004827
7PIM22.57764871
8KDR2.51003115
9BMPR22.22613951
10MYLK2.18229448
11EPHA22.14008785
12RIPK42.04966388
13PKN22.01853735
14RPS6KA42.00167464
15LIMK11.92364996
16LRRK21.92161965
17TESK21.90230959
18SCYL21.80697005
19PAK41.71388081
20TRPM71.66677599
21STK101.66220052
22ERN11.65377230
23MAP3K31.65034504
24MAPKAPK31.64013642
25MUSK1.61944462
26EPHB21.54558915
27NEK91.53351769
28DMPK1.51031624
29ILK1.50094203
30TGFBR11.40652772
31MAP2K31.40466748
32GRK61.40305649
33TGFBR21.37686649
34BTK1.36154817
35OBSCN1.35525696
36TBK11.34751613
37TIE11.34089836
38CSF1R1.33397843
39LATS21.29843201
40SYK1.25246651
41EIF2AK11.23349722
42RPS6KB21.22084563
43EIF2AK31.21810170
44FES1.19762149
45BUB11.18184817
46PDGFRA1.15552834
47PAK21.12661276
48GRK71.11646439
49DDR21.10091042
50MST41.09375907
51PIK3CA1.08447109
52JAK11.07804352
53JAK31.03327324
54LATS11.01550095
55PIK3CG0.98764086
56MAP3K110.98256699
57TAOK30.96254285
58FER0.96104963
59STK38L0.95272223
60VRK20.92947322
61HCK0.92803132
62PTK60.92698959
63MAP3K140.92325422
64PBK0.91515186
65ZAK0.91199007
66LCK0.87882577
67BMX0.87771507
68MAP3K80.87062390
69IKBKB0.85544093
70LYN0.84742105
71TYK20.83917460
72ZAP700.83826509
73MAP4K10.83776163
74MOS0.82292497
75STK240.79466690
76DAPK30.79331854
77DAPK10.77923996
78PIM10.77643524
79STK30.76104152
80FLT30.75898295
81SIK30.74802337
82PTK20.73799966
83PDK20.73493515
84STK40.72910775
85MAP3K100.72546475
86CDK60.70738458
87AURKB0.68435368
88ERBB30.67703411
89BLK0.66698785
90PTK2B0.64326437
91WEE10.63535797
92NEK10.63527848
93RIPK10.63468423
94MAPKAPK20.63066127
95PRKG20.62951815
96IRAK40.62885045
97ABL20.62766924
98CSK0.61890323
99EPHA30.60671375
100MST1R0.60664486
101FGFR40.60391196
102CHUK0.59730966
103EPHB10.58677308
104PRKD10.58589095
105EEF2K0.57636847
106TAOK20.55623998
107PAK10.54204859
108MET0.52077483
109DYRK1B0.52010526
110MAP3K130.51944221
111IGF1R0.51058230
112IRAK30.50446381
113MAPK120.50070313
114IKBKE0.49670644
115PRKCQ0.49364989
116PAK30.48970992
117* ROCK10.47367434
118STK160.47140807
119ITK0.46614477
120MAP3K50.46521594
121KIT0.46341214
122CDK70.43472419
123NUAK10.42741246
124ABL10.42321237
125BRSK20.41835852
126NEK20.41131518
127PHKG20.40978848
128PHKG10.40978848
129TLK10.40885936
130NLK0.40610247
131MARK30.39628832
132FGR0.39534502
133ARAF0.39041044
134ROCK20.38628776
135TEC0.38146400
136JAK20.36832253
137CDK80.35047211
138PRKCD0.31721801
139ACVR1B0.31668284
140ADRBK10.30240483

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.91045891
2Viral myocarditis_Homo sapiens_hsa054162.27053294
3Proteasome_Homo sapiens_hsa030502.25034245
4Type I diabetes mellitus_Homo sapiens_hsa049402.23612164
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.13066802
6ECM-receptor interaction_Homo sapiens_hsa045122.10907680
7Staphylococcus aureus infection_Homo sapiens_hsa051502.08639612
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88453011
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87470276
10Oxidative phosphorylation_Homo sapiens_hsa001901.87284615
11p53 signaling pathway_Homo sapiens_hsa041151.79568608
12Dilated cardiomyopathy_Homo sapiens_hsa054141.79259262
13Adherens junction_Homo sapiens_hsa045201.77598194
14* Focal adhesion_Homo sapiens_hsa045101.77315653
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75089956
16Small cell lung cancer_Homo sapiens_hsa052221.73668033
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67882553
18Malaria_Homo sapiens_hsa051441.63556886
19* Leukocyte transendothelial migration_Homo sapiens_hsa046701.62367679
20Shigellosis_Homo sapiens_hsa051311.61107206
21Leishmaniasis_Homo sapiens_hsa051401.52585495
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51166016
23Proteoglycans in cancer_Homo sapiens_hsa052051.48442104
24Legionellosis_Homo sapiens_hsa051341.47149119
25DNA replication_Homo sapiens_hsa030301.37583286
26TGF-beta signaling pathway_Homo sapiens_hsa043501.33144871
27Apoptosis_Homo sapiens_hsa042101.31664202
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30954366
29Graft-versus-host disease_Homo sapiens_hsa053321.28214731
30Amoebiasis_Homo sapiens_hsa051461.26960165
31Toxoplasmosis_Homo sapiens_hsa051451.26648231
32T cell receptor signaling pathway_Homo sapiens_hsa046601.26585909
33Bladder cancer_Homo sapiens_hsa052191.26210523
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26031724
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24974809
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.24473693
37Antigen processing and presentation_Homo sapiens_hsa046121.24229518
38Alzheimers disease_Homo sapiens_hsa050101.19939173
39Sulfur metabolism_Homo sapiens_hsa009201.19264346
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18377238
41Measles_Homo sapiens_hsa051621.17956450
42HTLV-I infection_Homo sapiens_hsa051661.14830942
43TNF signaling pathway_Homo sapiens_hsa046681.12449754
44Salmonella infection_Homo sapiens_hsa051321.12056210
45MicroRNAs in cancer_Homo sapiens_hsa052061.11717119
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10216517
47Hippo signaling pathway_Homo sapiens_hsa043901.07944486
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04498507
49Cell cycle_Homo sapiens_hsa041101.03930253
50Herpes simplex infection_Homo sapiens_hsa051681.03360318
51Allograft rejection_Homo sapiens_hsa053301.02335250
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00760128
53HIF-1 signaling pathway_Homo sapiens_hsa040661.00363055
54Chronic myeloid leukemia_Homo sapiens_hsa052200.99147748
55Base excision repair_Homo sapiens_hsa034100.98197539
56Hematopoietic cell lineage_Homo sapiens_hsa046400.97624662
57Spliceosome_Homo sapiens_hsa030400.97330644
58Pertussis_Homo sapiens_hsa051330.97238809
59* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97127111
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96535936
61RNA transport_Homo sapiens_hsa030130.94462660
62Epstein-Barr virus infection_Homo sapiens_hsa051690.94122760
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.93606787
64Viral carcinogenesis_Homo sapiens_hsa052030.92262157
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91917012
66RNA polymerase_Homo sapiens_hsa030200.91139423
67Osteoclast differentiation_Homo sapiens_hsa043800.90320172
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89218802
69Hepatitis B_Homo sapiens_hsa051610.87381859
70* Tight junction_Homo sapiens_hsa045300.86299508
71Nucleotide excision repair_Homo sapiens_hsa034200.86119432
72One carbon pool by folate_Homo sapiens_hsa006700.83976917
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.83940474
74Mismatch repair_Homo sapiens_hsa034300.82923956
75Huntingtons disease_Homo sapiens_hsa050160.80360035
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78571611
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76354018
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76230372
79Pathways in cancer_Homo sapiens_hsa052000.75123521
80B cell receptor signaling pathway_Homo sapiens_hsa046620.74591148
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74029417
82Autoimmune thyroid disease_Homo sapiens_hsa053200.73423184
83Chemokine signaling pathway_Homo sapiens_hsa040620.72318721
84Influenza A_Homo sapiens_hsa051640.72117430
85Thyroid cancer_Homo sapiens_hsa052160.69053449
86Cardiac muscle contraction_Homo sapiens_hsa042600.68516370
87Other glycan degradation_Homo sapiens_hsa005110.68494985
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68379354
89Primary immunodeficiency_Homo sapiens_hsa053400.68280449
90Protein export_Homo sapiens_hsa030600.68129178
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.66792352
92Acute myeloid leukemia_Homo sapiens_hsa052210.66009657
93Glutathione metabolism_Homo sapiens_hsa004800.64886786
94Tuberculosis_Homo sapiens_hsa051520.64786622
95Homologous recombination_Homo sapiens_hsa034400.64490439
96Pyrimidine metabolism_Homo sapiens_hsa002400.64342549
97* Platelet activation_Homo sapiens_hsa046110.64209242
98Pentose phosphate pathway_Homo sapiens_hsa000300.63697877
99Pancreatic cancer_Homo sapiens_hsa052120.61816315
100Basal cell carcinoma_Homo sapiens_hsa052170.60331089
101Notch signaling pathway_Homo sapiens_hsa043300.59809298
102Melanoma_Homo sapiens_hsa052180.57995647
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57855687
104Systemic lupus erythematosus_Homo sapiens_hsa053220.57389268
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56786834
106Lysosome_Homo sapiens_hsa041420.56393421
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56303260
108African trypanosomiasis_Homo sapiens_hsa051430.53756243
109Galactose metabolism_Homo sapiens_hsa000520.53675237
110Phagosome_Homo sapiens_hsa041450.53603847
111Prostate cancer_Homo sapiens_hsa052150.53249490
112Endocytosis_Homo sapiens_hsa041440.53023010
113Fatty acid elongation_Homo sapiens_hsa000620.52636826
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52222974
115Parkinsons disease_Homo sapiens_hsa050120.51674590
116Protein digestion and absorption_Homo sapiens_hsa049740.51274836
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50238617
118Rap1 signaling pathway_Homo sapiens_hsa040150.50120813
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48823278
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47756274
121Rheumatoid arthritis_Homo sapiens_hsa053230.44635501
122Asthma_Homo sapiens_hsa053100.44610225
123Starch and sucrose metabolism_Homo sapiens_hsa005000.41503113
124Complement and coagulation cascades_Homo sapiens_hsa046100.41443210
125Arachidonic acid metabolism_Homo sapiens_hsa005900.39033381
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38039091
127Regulation of autophagy_Homo sapiens_hsa041400.33843048
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31702548
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.28834622
130Chemical carcinogenesis_Homo sapiens_hsa052040.24834543
131Nitrogen metabolism_Homo sapiens_hsa009100.24437104
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23328059
133Collecting duct acid secretion_Homo sapiens_hsa049660.23203752
134Carbon metabolism_Homo sapiens_hsa012000.23155722
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.21752222
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18172368
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16991393
138Hepatitis C_Homo sapiens_hsa051600.14833815

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