MYL12AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.44626557
2cytidine catabolic process (GO:0006216)7.44626557
3cytidine deamination (GO:0009972)7.44626557
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.59819643
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.38480545
6DNA deamination (GO:0045006)6.31833630
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.62701917
8actin nucleation (GO:0045010)5.18694428
9positive T cell selection (GO:0043368)4.89959135
10positive thymic T cell selection (GO:0045059)4.66487884
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.60521724
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.59343083
13negative T cell selection (GO:0043383)4.47563901
14T cell migration (GO:0072678)4.42101368
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.34435425
16ATP synthesis coupled proton transport (GO:0015986)4.34435425
17sequestering of actin monomers (GO:0042989)4.33589434
18regulation of B cell receptor signaling pathway (GO:0050855)4.32947174
19positive regulation of calcium-mediated signaling (GO:0050850)4.29006787
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05204749
21negative regulation of T cell apoptotic process (GO:0070233)4.02868509
22T cell costimulation (GO:0031295)3.93727031
23T cell receptor signaling pathway (GO:0050852)3.89810612
24lymphocyte costimulation (GO:0031294)3.89213713
25cytolysis (GO:0019835)3.84689060
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68693335
27positive regulation of T cell mediated cytotoxicity (GO:0001916)3.63502209
28regulation of activation of Janus kinase activity (GO:0010533)3.62696819
29respiratory electron transport chain (GO:0022904)3.59680927
30protein neddylation (GO:0045116)3.58271494
31electron transport chain (GO:0022900)3.57253429
32positive regulation of interleukin-8 secretion (GO:2000484)3.56313214
33positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.55621686
34negative thymic T cell selection (GO:0045060)3.48373749
35regulation of T cell receptor signaling pathway (GO:0050856)3.41260475
36positive regulation of protein homodimerization activity (GO:0090073)3.40941602
37regulation of interleukin-8 secretion (GO:2000482)3.38976923
38antigen processing and presentation via MHC class Ib (GO:0002475)3.37907568
39thymic T cell selection (GO:0045061)3.36326328
40positive regulation of monocyte chemotaxis (GO:0090026)3.35939410
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.33088390
42antigen receptor-mediated signaling pathway (GO:0050851)3.30376730
43pyrimidine nucleoside catabolic process (GO:0046135)3.29878897
44negative regulation by host of viral transcription (GO:0043922)3.26980942
45eosinophil chemotaxis (GO:0048245)3.26246476
46positive regulation of natural killer cell mediated immunity (GO:0002717)3.25897981
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.25057190
48positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.24857153
49macrophage chemotaxis (GO:0048246)3.24646323
50T cell selection (GO:0045058)3.24472352
51regulation of cellular amino acid metabolic process (GO:0006521)3.24159375
52positive regulation of gamma-delta T cell activation (GO:0046645)3.21188383
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20542210
54antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19066797
55positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17906985
56negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17112009
57regulation of T cell mediated cytotoxicity (GO:0001914)3.16584518
58regulation of T cell tolerance induction (GO:0002664)3.15581578
59regulation of alpha-beta T cell proliferation (GO:0046640)3.15370680
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13976697
61negative regulation of viral genome replication (GO:0045071)3.13403110
62regulation of calcium-mediated signaling (GO:0050848)3.13115677
63negative regulation of calcium ion transport into cytosol (GO:0010523)3.13015812
64response to interferon-beta (GO:0035456)3.12225358
65regulation of chronic inflammatory response (GO:0002676)3.12156332
66negative regulation of mast cell activation (GO:0033004)3.12037441
67positive regulation of tolerance induction (GO:0002645)3.11397401
68cellular response to interleukin-15 (GO:0071350)3.11327841
69regulation of leukocyte mediated cytotoxicity (GO:0001910)3.11161376
70negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.07469256
71positive regulation of cell killing (GO:0031343)3.07427505
72platelet dense granule organization (GO:0060155)3.05616079
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01728920
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01728920
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00681715
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00681715
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00681715
78eosinophil migration (GO:0072677)2.98757915
79regulation of regulatory T cell differentiation (GO:0045589)2.96506247
80lymphocyte chemotaxis (GO:0048247)2.92035190
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90173955
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88652246
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88652246
84lymphocyte migration (GO:0072676)2.88370921
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83467906
86chemokine-mediated signaling pathway (GO:0070098)2.83358256
87negative regulation of lymphocyte apoptotic process (GO:0070229)2.81827894
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.81019983
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81019983
90positive regulation of interleukin-1 beta secretion (GO:0050718)2.80260016
91regulation of T cell chemotaxis (GO:0010819)2.79692113
92positive regulation of T cell chemotaxis (GO:0010820)2.79692113
93immunoglobulin mediated immune response (GO:0016064)2.79418853
94establishment of protein localization to mitochondrial membrane (GO:0090151)2.79386829
95positive regulation of defense response to virus by host (GO:0002230)2.78330763
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.77496122
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.75264138
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75126174
99regulation of natural killer cell mediated immunity (GO:0002715)2.75126174
100positive regulation of lymphocyte migration (GO:2000403)2.73989810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.45574447
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76367707
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74312237
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.48547684
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47014993
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17284765
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.12654205
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03411164
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95279209
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.59734540
11MYB_26560356_Chip-Seq_TH2_Human2.44232684
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21412396
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21196608
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.19781055
15VDR_22108803_ChIP-Seq_LS180_Human2.12582286
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96106166
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94372189
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.93072586
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92975373
20RUNX_20019798_ChIP-Seq_JUKART_Human1.88642210
21TAF15_26573619_Chip-Seq_HEK293_Human1.87704945
22GATA3_26560356_Chip-Seq_TH2_Human1.83828646
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82523921
24GATA3_27048872_Chip-Seq_THYMUS_Human1.80892368
25VDR_23849224_ChIP-Seq_CD4+_Human1.79149776
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69174343
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65763480
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63233826
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62052994
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55443799
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53022369
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52852008
33PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44929693
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44307851
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42403188
36AR_20517297_ChIP-Seq_VCAP_Human1.41054277
37ELK1_19687146_ChIP-ChIP_HELA_Human1.40523221
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38585158
39ZNF274_21170338_ChIP-Seq_K562_Hela1.36503472
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36062019
41MYB_26560356_Chip-Seq_TH1_Human1.35395946
42NANOG_19829295_ChIP-Seq_ESCs_Human1.34629148
43SOX2_19829295_ChIP-Seq_ESCs_Human1.34629148
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33890564
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32371137
46EZH2_22144423_ChIP-Seq_EOC_Human1.31838760
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30208694
48TP53_22573176_ChIP-Seq_HFKS_Human1.30177714
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.27255874
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27255874
51HTT_18923047_ChIP-ChIP_STHdh_Human1.26380948
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25762749
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24089267
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23786042
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23611479
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23217723
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.22499898
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20981773
59GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20865648
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18731794
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17960784
62TAF2_19829295_ChIP-Seq_ESCs_Human1.17729316
63IGF1R_20145208_ChIP-Seq_DFB_Human1.17603064
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16958316
65P300_19829295_ChIP-Seq_ESCs_Human1.14762457
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.14297111
67ERG_20517297_ChIP-Seq_VCAP_Human1.12913185
68EWS_26573619_Chip-Seq_HEK293_Human1.12272945
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.11761580
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11630262
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11196269
72CBP_20019798_ChIP-Seq_JUKART_Human1.11196269
73ER_23166858_ChIP-Seq_MCF-7_Human1.11017014
74NCOR_22424771_ChIP-Seq_293T_Human1.09671654
75NANOG_20526341_ChIP-Seq_ESCs_Human1.08767080
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.07806374
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07638344
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06558978
79GATA6_21074721_ChIP-Seq_CACO-2_Human1.03894295
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03119127
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02919897
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02818521
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02806338
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02582279
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01320300
86SPI1_23547873_ChIP-Seq_NB4_Human1.00973105
87RBPJ_21746931_ChIP-Seq_IB4_Human1.00804306
88FOXP3_21729870_ChIP-Seq_TREG_Human1.00034434
89CIITA_25753668_ChIP-Seq_RAJI_Human0.99018134
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97919026
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.97754463
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.97530247
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97112672
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96986805
95GATA3_26560356_Chip-Seq_TH1_Human0.96635116
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96213602
97IRF8_27001747_Chip-Seq_BMDM_Mouse0.95430496
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.94386376
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92952633
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92152990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.33185610
2MP0009785_altered_susceptibility_to3.91744100
3MP0001835_abnormal_antigen_presentation3.83182099
4MP0003763_abnormal_thymus_physiology3.06229168
5MP0002166_altered_tumor_susceptibility2.78779807
6MP0009333_abnormal_splenocyte_physiolog2.45230224
7MP0001800_abnormal_humoral_immune2.44377242
8MP0002138_abnormal_hepatobiliary_system2.34861865
9MP0005000_abnormal_immune_tolerance2.32168514
10MP0009379_abnormal_foot_pigmentation2.29016607
11MP0002102_abnormal_ear_morphology2.22744112
12MP0005025_abnormal_response_to2.20494546
13MP0002006_tumorigenesis2.16493654
14MP0002420_abnormal_adaptive_immunity2.11701895
15MP0000685_abnormal_immune_system2.11546541
16MP0004147_increased_porphyrin_level2.10639796
17MP0001819_abnormal_immune_cell2.08237951
18MP0002148_abnormal_hypersensitivity_rea2.06184145
19MP0003866_abnormal_defecation2.03402762
20MP0002723_abnormal_immune_serum2.01587819
21MP0003724_increased_susceptibility_to1.90388287
22MP0002452_abnormal_antigen_presenting1.89618974
23MP0005084_abnormal_gallbladder_morpholo1.78437762
24MP0001790_abnormal_immune_system1.78196209
25MP0005387_immune_system_phenotype1.78196209
26MP0006054_spinal_hemorrhage1.78139744
27MP0010155_abnormal_intestine_physiology1.77151224
28MP0001873_stomach_inflammation1.74124743
29MP0006082_CNS_inflammation1.67794179
30MP0003880_abnormal_central_pattern1.63945915
31MP0003448_altered_tumor_morphology1.59960102
32MP0002933_joint_inflammation1.56468895
33MP0000716_abnormal_immune_system1.51510892
34MP0006072_abnormal_retinal_apoptosis1.50310761
35MP0008872_abnormal_physiological_respon1.49562513
36MP0003283_abnormal_digestive_organ1.43147775
37MP0002398_abnormal_bone_marrow1.41289227
38MP0002419_abnormal_innate_immunity1.39785481
39MP0000372_irregular_coat_pigmentation1.34947449
40MP0001845_abnormal_inflammatory_respons1.34580053
41MP0009764_decreased_sensitivity_to1.33820055
42MP0005645_abnormal_hypothalamus_physiol1.31072683
43MP0010386_abnormal_urinary_bladder1.30990587
44MP0003878_abnormal_ear_physiology1.28061157
45MP0005377_hearing/vestibular/ear_phenot1.28061157
46MP0003045_fibrosis1.26667021
47MP0003011_delayed_dark_adaptation1.26400040
48MP0000858_altered_metastatic_potential1.26276380
49MP0003252_abnormal_bile_duct1.25221449
50MP0002405_respiratory_system_inflammati1.25218724
51MP0001919_abnormal_reproductive_system1.15434691
52MP0000703_abnormal_thymus_morphology1.14236567
53MP0002722_abnormal_immune_system1.14013777
54MP0004145_abnormal_muscle_electrophysio1.13444439
55MP0000689_abnormal_spleen_morphology1.12236923
56MP0002234_abnormal_pharynx_morphology1.11974260
57MP0008875_abnormal_xenobiotic_pharmacok1.10168032
58MP0008995_early_reproductive_senescence1.10053582
59MP0005551_abnormal_eye_electrophysiolog1.09621552
60MP0005083_abnormal_biliary_tract1.07670076
61MP0001188_hyperpigmentation1.07456297
62MP0002429_abnormal_blood_cell1.07411803
63MP0008469_abnormal_protein_level1.05813009
64MP0002837_dystrophic_cardiac_calcinosis1.04715683
65MP0003137_abnormal_impulse_conducting1.04554939
66MP0003436_decreased_susceptibility_to1.03881304
67MP0001905_abnormal_dopamine_level1.00962879
68MP0005166_decreased_susceptibility_to1.00890345
69MP0002876_abnormal_thyroid_physiology0.99211293
70MP0002736_abnormal_nociception_after0.98823582
71MP0009763_increased_sensitivity_to0.98632284
72MP0003806_abnormal_nucleotide_metabolis0.95329669
73MP0001968_abnormal_touch/_nociception0.94288996
74MP0001986_abnormal_taste_sensitivity0.92429344
75MP0005253_abnormal_eye_physiology0.91571663
76MP0002277_abnormal_respiratory_mucosa0.90466718
77MP0003786_premature_aging0.90423914
78MP0005075_abnormal_melanosome_morpholog0.89219273
79MP0001542_abnormal_bone_strength0.86102911
80MP0002638_abnormal_pupillary_reflex0.84489915
81MP0001853_heart_inflammation0.83950756
82MP0005503_abnormal_tendon_morphology0.81992261
83MP0006036_abnormal_mitochondrial_physio0.81915521
84MP0005464_abnormal_platelet_physiology0.81781434
85MP0001533_abnormal_skeleton_physiology0.81158767
86MP0009643_abnormal_urine_homeostasis0.80094486
87MP0005636_abnormal_mineral_homeostasis0.80067271
88MP0001485_abnormal_pinna_reflex0.78938317
89MP0005085_abnormal_gallbladder_physiolo0.76059850
90MP0002693_abnormal_pancreas_physiology0.73985032
91MP0001664_abnormal_digestion0.72496742
92MP0005389_reproductive_system_phenotype0.72373367
93MP0004134_abnormal_chest_morphology0.70843207
94MP0003646_muscle_fatigue0.70149120
95MP0003195_calcinosis0.69811929
96MP0006276_abnormal_autonomic_nervous0.69756335
97MP0004947_skin_inflammation0.68374729
98MP0001501_abnormal_sleep_pattern0.68330865
99MP0002019_abnormal_tumor_incidence0.67362183
100MP0003075_altered_response_to0.67106461

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.81914380
2IgG deficiency (HP:0004315)4.74849179
3Autoimmune hemolytic anemia (HP:0001890)4.70817044
4Hypoproteinemia (HP:0003075)4.69828020
5T lymphocytopenia (HP:0005403)4.68487934
6Abnormality of T cell number (HP:0011839)4.60462862
7Elevated erythrocyte sedimentation rate (HP:0003565)4.02014706
83-Methylglutaconic aciduria (HP:0003535)3.95965957
9Congenital stationary night blindness (HP:0007642)3.73232520
10Abnormality of B cell number (HP:0010975)3.69718273
11Severe combined immunodeficiency (HP:0004430)3.69189169
12Mitochondrial inheritance (HP:0001427)3.60004849
13Increased IgM level (HP:0003496)3.57911083
14Abnormality of the prostate (HP:0008775)3.51057139
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.48002208
16Hepatocellular necrosis (HP:0001404)3.31900079
17Abnormality of T cells (HP:0002843)3.21356001
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17706176
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17706176
20Increased intramyocellular lipid droplets (HP:0012240)3.11000302
21Autoimmune thrombocytopenia (HP:0001973)3.04721618
22Acute necrotizing encephalopathy (HP:0006965)3.04533213
23Increased CSF lactate (HP:0002490)3.01847284
24Abnormal rod and cone electroretinograms (HP:0008323)3.01100426
25Hepatic necrosis (HP:0002605)2.97622519
26Congenital, generalized hypertrichosis (HP:0004540)2.96180375
27Abnormal mitochondria in muscle tissue (HP:0008316)2.95302621
28B lymphocytopenia (HP:0010976)2.95030784
29Stomatitis (HP:0010280)2.91430300
30Increased hepatocellular lipid droplets (HP:0006565)2.91087154
31Combined immunodeficiency (HP:0005387)2.86453762
32Renal Fanconi syndrome (HP:0001994)2.84523599
33Thyroiditis (HP:0100646)2.82621521
34Abnormality of eosinophils (HP:0001879)2.72762333
35Pancytopenia (HP:0001876)2.67868361
36Oral leukoplakia (HP:0002745)2.54625337
37Radial bowing (HP:0002986)2.53157610
38Recurrent bronchitis (HP:0002837)2.52685710
39Lipid accumulation in hepatocytes (HP:0006561)2.51519149
40Acute encephalopathy (HP:0006846)2.49127005
41Progressive macrocephaly (HP:0004481)2.48922672
42Eosinophilia (HP:0001880)2.48403407
43Cerebral palsy (HP:0100021)2.47906602
44Abnormal albumin level (HP:0012116)2.46454895
45Hypoalbuminemia (HP:0003073)2.46454895
46Increased muscle lipid content (HP:0009058)2.45474705
47Obstructive lung disease (HP:0006536)2.43818021
48Chronic obstructive pulmonary disease (HP:0006510)2.43818021
49Methylmalonic acidemia (HP:0002912)2.42429178
50Azoospermia (HP:0000027)2.33247265
51Generalized aminoaciduria (HP:0002909)2.33145736
52Meningitis (HP:0001287)2.31559393
53Chronic diarrhea (HP:0002028)2.28573291
54Hemoptysis (HP:0002105)2.26496130
55Vasculitis (HP:0002633)2.24806505
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23688984
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22101847
58Stomach cancer (HP:0012126)2.18623562
59Absent/shortened dynein arms (HP:0200106)2.16662183
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.16662183
61Abnormal spermatogenesis (HP:0008669)2.13595783
62Lymphopenia (HP:0001888)2.13278518
63Chronic mucocutaneous candidiasis (HP:0002728)2.12864401
64Recurrent cutaneous fungal infections (HP:0011370)2.12864401
65Pancreatic cysts (HP:0001737)2.11398147
66Exertional dyspnea (HP:0002875)2.09623317
67Abnormality of the pleura (HP:0002103)2.09407413
68Attenuation of retinal blood vessels (HP:0007843)2.09188754
69Bronchitis (HP:0012387)2.07055565
70Constricted visual fields (HP:0001133)2.06734021
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.05915184
72Gangrene (HP:0100758)2.05397395
73Cerebral edema (HP:0002181)2.05239021
74Pulmonary infiltrates (HP:0002113)2.02162884
75Prostate neoplasm (HP:0100787)2.01107807
76Increased serum lactate (HP:0002151)1.99635285
77Acute hepatic failure (HP:0006554)1.99131251
78Lactic acidosis (HP:0003128)1.97141634
79Encephalitis (HP:0002383)1.96168831
80Pustule (HP:0200039)1.95504374
81Optic disc pallor (HP:0000543)1.95489141
82Lymphoma (HP:0002665)1.95122687
83Decreased central vision (HP:0007663)1.94823060
84Leukocytosis (HP:0001974)1.93476233
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92334220
86Type I transferrin isoform profile (HP:0003642)1.89699891
87Ureteral stenosis (HP:0000071)1.89559821
88True hermaphroditism (HP:0010459)1.87200278
89Renal cortical cysts (HP:0000803)1.87174453
90Abnormality of male internal genitalia (HP:0000022)1.86326403
91Abolished electroretinogram (ERG) (HP:0000550)1.85241935
92Gastrointestinal infarctions (HP:0005244)1.85049482
93Abnormality of renal resorption (HP:0011038)1.83548034
94Abnormality of T cell physiology (HP:0011840)1.82363153
95Pulmonary fibrosis (HP:0002206)1.81548998
96Recurrent fungal infections (HP:0002841)1.80439426
97Skin rash (HP:0000988)1.79546826
98IgM deficiency (HP:0002850)1.79353461
99Severe visual impairment (HP:0001141)1.78023577
100Abnormality of macrophages (HP:0004311)1.77760289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.16918027
2KDR5.10872470
3MAP3K123.71654167
4TAOK33.13054565
5TESK22.90405354
6SCYL22.89938276
7TLK12.59044472
8BCKDK2.44089305
9ITK2.42590760
10MAP4K12.37122654
11MYLK2.27850507
12BMPR22.10946455
13ADRBK22.06543339
14ZAK1.83988348
15GRK11.79533622
16CDK191.68300445
17MAP4K21.62486417
18BUB11.61961585
19STK161.55176289
20MST41.52082451
21SYK1.46200267
22VRK21.43990875
23BTK1.41418054
24EIF2AK31.41004268
25ERBB31.40999457
26PINK11.38980636
27TEC1.35316098
28MUSK1.33760557
29GRK61.32018215
30NUAK11.24520773
31NEK11.18575034
32TESK11.18492452
33CSK1.16893384
34FES1.14558211
35GRK71.09041503
36LCK1.07120336
37PASK1.04989619
38ZAP701.03911966
39CDK81.02756315
40VRK11.01232859
41LIMK11.00515256
42FRK0.99955017
43KIT0.97314606
44OXSR10.95021130
45PRKCQ0.93358498
46MAPKAPK30.93129879
47INSRR0.92907814
48LYN0.89646491
49ILK0.88495486
50TRPM70.88259511
51ROCK10.87790003
52WNK40.87342005
53DAPK10.86195925
54JAK30.82685364
55IKBKB0.80460698
56CSF1R0.75202465
57IGF1R0.73890885
58OBSCN0.72559279
59TIE10.66768840
60RIPK40.65706433
61CAMKK20.62893282
62PIK3CA0.60780905
63MAP3K110.58089116
64HCK0.54072540
65WNK30.50444747
66FYN0.50195965
67DAPK30.46111524
68PRKCA0.45033286
69RPS6KA50.44473185
70PLK20.44385940
71ABL10.43042015
72IKBKE0.42310571
73LMTK20.40760671
74ERBB20.39800698
75PIM10.39190394
76STK390.39010752
77CAMK2A0.38348995
78ADRBK10.38123603
79INSR0.36135067
80TRIM280.36000262
81PAK10.35485119
82BLK0.34858499
83CSNK1G30.33704977
84PRKACA0.33508331
85BMPR1B0.33320830
86PIK3CG0.32643835
87MATK0.32340904
88CSNK1A10.31225991
89PAK40.31097491
90CSNK2A10.30878518
91TBK10.30460030
92PRKCD0.29077480
93EGFR0.29049173
94PHKG20.27492310
95PHKG10.27492310
96MAP2K60.23547922
97MAPK130.22049606
98PRKCE0.21501298
99PRKCB0.21259280
100CAMKK10.20823511

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.40814421
2Proteasome_Homo sapiens_hsa030504.04677117
3Graft-versus-host disease_Homo sapiens_hsa053323.81631408
4Autoimmune thyroid disease_Homo sapiens_hsa053203.63537340
5Allograft rejection_Homo sapiens_hsa053303.63366034
6Asthma_Homo sapiens_hsa053103.43183065
7Antigen processing and presentation_Homo sapiens_hsa046123.25582968
8Oxidative phosphorylation_Homo sapiens_hsa001903.23544566
9Type I diabetes mellitus_Homo sapiens_hsa049402.92747719
10Parkinsons disease_Homo sapiens_hsa050122.66736230
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.63723276
12Hematopoietic cell lineage_Homo sapiens_hsa046402.16634375
13Rheumatoid arthritis_Homo sapiens_hsa053232.10606121
14Ribosome_Homo sapiens_hsa030101.96882360
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89873273
16Alzheimers disease_Homo sapiens_hsa050101.87047612
17Viral myocarditis_Homo sapiens_hsa054161.86236619
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85238528
19Protein export_Homo sapiens_hsa030601.78520600
20T cell receptor signaling pathway_Homo sapiens_hsa046601.70252435
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64774004
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61457618
23Cardiac muscle contraction_Homo sapiens_hsa042601.53922543
24Huntingtons disease_Homo sapiens_hsa050161.51688583
25Staphylococcus aureus infection_Homo sapiens_hsa051501.49702967
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44047086
27Nitrogen metabolism_Homo sapiens_hsa009101.42738099
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42143195
29Phototransduction_Homo sapiens_hsa047441.24247450
30RNA polymerase_Homo sapiens_hsa030201.10676850
31Systemic lupus erythematosus_Homo sapiens_hsa053221.10337226
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00228832
33Leishmaniasis_Homo sapiens_hsa051400.98287150
34Malaria_Homo sapiens_hsa051440.97753470
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.87436177
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87391057
37Salmonella infection_Homo sapiens_hsa051320.85609445
38Caffeine metabolism_Homo sapiens_hsa002320.85597017
39One carbon pool by folate_Homo sapiens_hsa006700.84539896
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78858997
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75726881
42Measles_Homo sapiens_hsa051620.74917789
43Linoleic acid metabolism_Homo sapiens_hsa005910.73708383
44Shigellosis_Homo sapiens_hsa051310.73236552
45Tryptophan metabolism_Homo sapiens_hsa003800.67476450
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66344413
47Chemical carcinogenesis_Homo sapiens_hsa052040.62624492
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60762090
49Regulation of autophagy_Homo sapiens_hsa041400.59754711
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59169740
51Collecting duct acid secretion_Homo sapiens_hsa049660.58880896
52Retinol metabolism_Homo sapiens_hsa008300.53815623
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.52771402
54Peroxisome_Homo sapiens_hsa041460.52676015
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52615331
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51993625
57Olfactory transduction_Homo sapiens_hsa047400.49258177
58Herpes simplex infection_Homo sapiens_hsa051680.48682945
59RNA degradation_Homo sapiens_hsa030180.46433433
60Phagosome_Homo sapiens_hsa041450.44250168
61Propanoate metabolism_Homo sapiens_hsa006400.43548212
62Butanoate metabolism_Homo sapiens_hsa006500.41599500
63Homologous recombination_Homo sapiens_hsa034400.41289056
64Tuberculosis_Homo sapiens_hsa051520.40684679
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40296758
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38907224
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36741156
68African trypanosomiasis_Homo sapiens_hsa051430.36397731
69Purine metabolism_Homo sapiens_hsa002300.35619281
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.34160551
71Taste transduction_Homo sapiens_hsa047420.32388222
72Legionellosis_Homo sapiens_hsa051340.32343267
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.31712290
74Influenza A_Homo sapiens_hsa051640.31051452
75Nucleotide excision repair_Homo sapiens_hsa034200.30146815
76Pyrimidine metabolism_Homo sapiens_hsa002400.27111320
77Epstein-Barr virus infection_Homo sapiens_hsa051690.26466772
78HTLV-I infection_Homo sapiens_hsa051660.26010018
79Pertussis_Homo sapiens_hsa051330.25929261
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25131044
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24246253
82Metabolic pathways_Homo sapiens_hsa011000.23669123
83ABC transporters_Homo sapiens_hsa020100.22427812
84Chemokine signaling pathway_Homo sapiens_hsa040620.21055105
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.20669320
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20231484
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19518673
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18204090
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16657332
90Basal transcription factors_Homo sapiens_hsa030220.16335240
91Nicotine addiction_Homo sapiens_hsa050330.16121939
92Arachidonic acid metabolism_Homo sapiens_hsa005900.16119874
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15028726
94Morphine addiction_Homo sapiens_hsa050320.13999214
95Glutathione metabolism_Homo sapiens_hsa004800.13324380
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13023163
97Ether lipid metabolism_Homo sapiens_hsa005650.12605028
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.11272310
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10914976
100Toxoplasmosis_Homo sapiens_hsa051450.10579216

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