MYL12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.76286894
2membrane raft organization (GO:0031579)4.49025611
3regulation of metalloenzyme activity (GO:0048552)4.46566072
4ribosomal small subunit assembly (GO:0000028)4.41586729
5Golgi transport vesicle coating (GO:0048200)4.35244293
6COPI coating of Golgi vesicle (GO:0048205)4.35244293
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22925001
8sequestering of actin monomers (GO:0042989)4.02685012
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94741785
10ATP synthesis coupled proton transport (GO:0015986)3.94741785
11protein maturation by protein folding (GO:0022417)3.80306674
12membrane budding (GO:0006900)3.77685853
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75236670
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66947148
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.61279544
16phagosome maturation (GO:0090382)3.59155179
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53060434
18protein complex biogenesis (GO:0070271)3.48626462
19negative regulation of ligase activity (GO:0051352)3.46801247
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46801247
21regulation of B cell receptor signaling pathway (GO:0050855)3.43054303
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40675392
23positive regulation of actin filament depolymerization (GO:0030836)3.40507126
24signal transduction involved in DNA damage checkpoint (GO:0072422)3.37098146
25signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37098146
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35096730
27antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.34620542
28transferrin transport (GO:0033572)3.32540756
29chaperone-mediated protein transport (GO:0072321)3.26058181
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.25936611
31ATP hydrolysis coupled proton transport (GO:0015991)3.23126548
32energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23126548
33intestinal epithelial cell development (GO:0060576)3.19836668
34desmosome organization (GO:0002934)3.17929581
35respiratory electron transport chain (GO:0022904)3.14744531
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14344312
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.14344312
38NADH dehydrogenase complex assembly (GO:0010257)3.14344312
39hepatocyte apoptotic process (GO:0097284)3.14035770
40regulation of cellular amine metabolic process (GO:0033238)3.13775270
41mast cell activation (GO:0045576)3.11730067
42response to interferon-beta (GO:0035456)3.11643719
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11218474
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10647911
45electron transport chain (GO:0022900)3.09806298
46protein heterotetramerization (GO:0051290)3.09310545
47viral transcription (GO:0019083)3.07194553
48nucleobase-containing small molecule interconversion (GO:0015949)3.04615998
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04494722
50mitochondrial respiratory chain complex assembly (GO:0033108)3.04317041
51Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04090423
52dopamine transport (GO:0015872)3.00854825
53trivalent inorganic cation transport (GO:0072512)2.99783326
54ferric iron transport (GO:0015682)2.99783326
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95031343
56positive regulation of ligase activity (GO:0051351)2.94874254
57cytochrome complex assembly (GO:0017004)2.93565203
58response to protozoan (GO:0001562)2.92513989
59cell adhesion mediated by integrin (GO:0033627)2.91823468
60GDP-mannose metabolic process (GO:0019673)2.90018729
61ribosomal small subunit biogenesis (GO:0042274)2.89364347
62translational termination (GO:0006415)2.89317748
63platelet dense granule organization (GO:0060155)2.87965520
64DNA deamination (GO:0045006)2.87377652
65synaptic vesicle exocytosis (GO:0016079)2.86907909
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84871805
67leukocyte aggregation (GO:0070486)2.84007713
68respiratory burst (GO:0045730)2.83785027
69regulation of integrin-mediated signaling pathway (GO:2001044)2.82550074
70respiratory chain complex IV assembly (GO:0008535)2.80612011
71positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.79528931
72nucleotide-sugar biosynthetic process (GO:0009226)2.78954113
73catecholamine transport (GO:0051937)2.78531017
74regulation of isotype switching to IgG isotypes (GO:0048302)2.78147378
75COPII vesicle coating (GO:0048208)2.75835117
76defense response to protozoan (GO:0042832)2.75803879
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75555950
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75555950
79positive regulation of Cdc42 GTPase activity (GO:0043089)2.75433562
80cotranslational protein targeting to membrane (GO:0006613)2.75165563
81skin morphogenesis (GO:0043589)2.74326251
82positive regulation of cell cycle arrest (GO:0071158)2.74104175
83neutrophil activation involved in immune response (GO:0002283)2.73549649
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73268589
85protein neddylation (GO:0045116)2.72811556
86protein targeting to ER (GO:0045047)2.67940447
87interferon-gamma production (GO:0032609)2.67922776
88actin filament depolymerization (GO:0030042)2.67075308
89negative regulation of phagocytosis (GO:0050765)2.66342545
90xenobiotic catabolic process (GO:0042178)2.65546196
91positive regulation of protein homodimerization activity (GO:0090073)2.65496927
92mast cell activation involved in immune response (GO:0002279)2.64926555
93mast cell degranulation (GO:0043303)2.64926555
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62248820
95cellular response to interferon-beta (GO:0035458)2.61389746
96antigen processing and presentation of endogenous antigen (GO:0019883)2.61283766
97protein localization to endoplasmic reticulum (GO:0070972)2.60812503
98positive regulation of cellular amine metabolic process (GO:0033240)2.60371461
99cellular response to interleukin-15 (GO:0071350)2.58577177
100DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.55966106
101viral life cycle (GO:0019058)2.54946002
102hydrogen ion transmembrane transport (GO:1902600)2.54625842
103ribosome assembly (GO:0042255)2.54101993
104cellular protein complex disassembly (GO:0043624)2.52673876
105regulation of T cell receptor signaling pathway (GO:0050856)2.52016362
106regulation of ubiquitin-protein transferase activity (GO:0051438)2.51832117
107positive regulation of gamma-delta T cell activation (GO:0046645)2.49535012
108cellular response to zinc ion (GO:0071294)2.49266713
109establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48962671
110translational elongation (GO:0006414)2.48896367
111negative regulation of protein ubiquitination (GO:0031397)2.48260525
112viral protein processing (GO:0019082)2.47694345
113positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.47660959
114NADH metabolic process (GO:0006734)2.46600199
115regulation of ligase activity (GO:0051340)2.46111093
116negative regulation of cell killing (GO:0031342)2.43552943
117negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43552943
118negative regulation of T cell receptor signaling pathway (GO:0050860)2.43539102
119negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.43531470
120regulation of cellular amino acid metabolic process (GO:0006521)2.42123322
121leukocyte degranulation (GO:0043299)2.41852496
122L-fucose metabolic process (GO:0042354)2.41052742
123L-fucose catabolic process (GO:0042355)2.41052742
124fucose catabolic process (GO:0019317)2.41052742
125deoxyribose phosphate biosynthetic process (GO:0046385)2.40843618
1262-deoxyribonucleotide biosynthetic process (GO:0009265)2.40843618
127glutathione derivative metabolic process (GO:1901685)2.39896869
128glutathione derivative biosynthetic process (GO:1901687)2.39896869
129endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.39800859
130L-phenylalanine metabolic process (GO:0006558)2.39337411
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.39337411
132positive regulation of lamellipodium assembly (GO:0010592)2.38881649
133negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.38647096
134interferon-gamma-mediated signaling pathway (GO:0060333)2.37887925
135diterpenoid biosynthetic process (GO:0016102)2.37668625
136proton transport (GO:0015992)2.36675389
137regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.36081214
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.35685811
139activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.35392322
140negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.34480484
141regulation of transforming growth factor beta1 production (GO:0032908)2.34204718
142regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33447866
143histamine secretion (GO:0001821)2.32865469
144negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.32844153
145vocalization behavior (GO:0071625)2.32525503
146cullin deneddylation (GO:0010388)2.32448497
147positive regulation of epidermal cell differentiation (GO:0045606)2.32349056
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32014960
149actin nucleation (GO:0045010)2.30653524
150intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.30566702
151signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.30566702
152negative regulation of type 2 immune response (GO:0002829)2.30434917
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.29911153
154hydrogen transport (GO:0006818)2.29702749
155positive regulation of keratinocyte differentiation (GO:0045618)2.28984386
156antigen processing and presentation via MHC class Ib (GO:0002475)2.28708651
157response to interleukin-15 (GO:0070672)2.28591255
158protein deneddylation (GO:0000338)2.28506816
159regulation of respiratory burst (GO:0060263)2.28485184
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27577030
161oxidative phosphorylation (GO:0006119)2.27407471
162type B pancreatic cell proliferation (GO:0044342)2.27354821
163barbed-end actin filament capping (GO:0051016)2.27158425
164deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.27019331
165signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.26850800
166signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.26850800
167signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.26850800
168maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.26388345
169cell redox homeostasis (GO:0045454)2.25881039
170regulation of interleukin-8 secretion (GO:2000482)2.25135792
171regulation of water loss via skin (GO:0033561)2.24506157
172regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.24335873
173negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.20796750
174negative regulation of cell cycle G1/S phase transition (GO:1902807)2.20796750
175protein retention in ER lumen (GO:0006621)2.20605680
176positive regulation of pseudopodium assembly (GO:0031274)2.19158652
177ER to Golgi vesicle-mediated transport (GO:0006888)2.17518515
178deoxyribonucleotide biosynthetic process (GO:0009263)2.17219504
179regulation of cell cycle arrest (GO:0071156)2.14806213
180signal transduction in response to DNA damage (GO:0042770)2.13753534
181negative regulation of protein localization to plasma membrane (GO:1903077)2.13581636
182cellular response to interferon-alpha (GO:0035457)2.13577931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.39579362
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.78957149
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76113168
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.61115436
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.56436768
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.54014008
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.37026790
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20037643
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.15384485
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07404639
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.03544552
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.99052754
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95260341
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94284088
15* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.87080567
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.86053908
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71578938
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.61709645
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.55866159
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51362695
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51296353
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46685268
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46227953
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.39382315
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35436807
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29809347
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27699935
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25656120
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25196333
30TAF15_26573619_Chip-Seq_HEK293_Human2.18024417
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16192515
32* SPI1_23547873_ChIP-Seq_NB4_Human2.14476203
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11884362
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08722626
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08722626
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08614677
37RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08482147
38HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07301683
39ESR1_21235772_ChIP-Seq_MCF-7_Human2.04464776
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02726405
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.93747197
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93163530
43SOX2_20726797_ChIP-Seq_SW620_Human1.91089128
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.87584619
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86257726
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85196589
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.83473832
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80886946
49VDR_23849224_ChIP-Seq_CD4+_Human1.79941349
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78652365
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78117411
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.76712393
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.76630031
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74876772
55ZNF263_19887448_ChIP-Seq_K562_Human1.73535811
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73261134
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.71923792
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71648291
59SCL_19346495_ChIP-Seq_HPC-7_Human1.69569011
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69428181
61RUNX_20019798_ChIP-Seq_JUKART_Human1.68268783
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67917438
63ELK1_19687146_ChIP-ChIP_HELA_Human1.64616089
64EZH2_22144423_ChIP-Seq_EOC_Human1.64169536
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.62335655
66GBX2_23144817_ChIP-Seq_PC3_Human1.61299709
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57742367
68MYB_26560356_Chip-Seq_TH2_Human1.55872447
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55612720
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.54490275
71ELF5_23300383_ChIP-Seq_T47D_Human1.53611470
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52659148
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.51639052
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49185308
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48524464
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.47737687
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42838086
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.41457530
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41087864
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40725720
81FOXP3_21729870_ChIP-Seq_TREG_Human1.40619427
82CLOCK_20551151_ChIP-Seq_293T_Human1.40617061
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38759738
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38409481
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38135263
86ATF3_27146783_Chip-Seq_COLON_Human1.37075979
87* GATA4_25053715_ChIP-Seq_YYC3_Human1.37036167
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.35871402
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.35227691
90TFEB_21752829_ChIP-Seq_HELA_Human1.34606799
91* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32838870
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.30518828
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30316008
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29056323
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28489909
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28441048
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28049125
98GATA6_25053715_ChIP-Seq_YYC3_Human1.27962653
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27900020
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.26675702
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26449696
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26206732
103RXR_22158963_ChIP-Seq_LIVER_Mouse1.25650817
104AR_21909140_ChIP-Seq_LNCAP_Human1.25118513
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.24921468
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24591199
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22562281
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22257271
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20387461
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19983391
111VDR_24763502_ChIP-Seq_THP-1_Human1.19598715
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19006924
113* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18991530
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18696075
115CJUN_26792858_Chip-Seq_BT549_Human1.18098640
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17596945
117* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16981515
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15774721
119BRD4_25478319_ChIP-Seq_HGPS_Human1.15222599
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13674252
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11148836
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10197973
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09682249
124IRF1_19129219_ChIP-ChIP_H3396_Human1.08588977
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08182954
126CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07908244
127* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06979366
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06501478
129* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06162747
130PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05473095
131DCP1A_22483619_ChIP-Seq_HELA_Human1.04826407
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03564852
133CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03458561
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03393874
135MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03374744
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02678273
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01816703
138MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01694273
139GATA3_26560356_Chip-Seq_TH2_Human1.01406940
140VDR_22108803_ChIP-Seq_LS180_Human1.01035866
141SPI1_23127762_ChIP-Seq_K562_Human1.00208572
142* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99375285
143ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99151623
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.98087552
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97599724
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96802275
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95113463
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.94791651
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94246250
150VDR_21846776_ChIP-Seq_THP-1_Human0.94151215
151TTF2_22483619_ChIP-Seq_HELA_Human0.93332996
152MAF_26560356_Chip-Seq_TH1_Human0.92855150
153MYB_26560356_Chip-Seq_TH1_Human0.92645140
154MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90342078
155E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90290750
156CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90012150
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89634122
158XRN2_22483619_ChIP-Seq_HELA_Human0.89506593
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88773819
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88676017
161SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.87481226
162GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87042643
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86638820
164GATA3_27048872_Chip-Seq_THYMUS_Human0.85554968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.22450692
2MP0003880_abnormal_central_pattern3.52112472
3MP0001835_abnormal_antigen_presentation3.31769854
4MP0003950_abnormal_plasma_membrane3.09367617
5MP0009785_altered_susceptibility_to3.02005864
6MP0010234_abnormal_vibrissa_follicle3.00278238
7MP0003724_increased_susceptibility_to2.93176098
8MP0005671_abnormal_response_to2.92624334
9MP0003191_abnormal_cellular_cholesterol2.86462036
10MP0005360_urolithiasis2.51869044
11MP0009379_abnormal_foot_pigmentation2.48666526
12MP0008438_abnormal_cutaneous_collagen2.48162108
13MP0002148_abnormal_hypersensitivity_rea2.45076209
14MP0001968_abnormal_touch/_nociception2.36482013
15MP0002736_abnormal_nociception_after2.35459334
16MP0009780_abnormal_chondrocyte_physiolo2.27447897
17MP0002796_impaired_skin_barrier2.23587972
18MP0003566_abnormal_cell_adhesion2.21012502
19MP0005025_abnormal_response_to2.16793025
20MP0009840_abnormal_foam_cell2.15098703
21MP0002735_abnormal_chemical_nociception2.14595121
22MP0004272_abnormal_basement_membrane2.12935515
23MP0003866_abnormal_defecation2.11521778
24MP0003186_abnormal_redox_activity2.09833548
25MP0006054_spinal_hemorrhage2.09182991
26MP0005000_abnormal_immune_tolerance2.08193343
27MP0003941_abnormal_skin_development2.04028095
28MP0003763_abnormal_thymus_physiology1.97774889
29MP0002420_abnormal_adaptive_immunity1.96998599
30MP0001188_hyperpigmentation1.96291160
31MP0001819_abnormal_immune_cell1.95908100
32MP0000685_abnormal_immune_system1.95313654
33MP0002877_abnormal_melanocyte_morpholog1.91433378
34MP0001905_abnormal_dopamine_level1.91026416
35MP0008875_abnormal_xenobiotic_pharmacok1.89912560
36MP0001986_abnormal_taste_sensitivity1.88293673
37MP0002419_abnormal_innate_immunity1.85493970
38MP0001873_stomach_inflammation1.83433039
39MP0002139_abnormal_hepatobiliary_system1.82334343
40MP0002723_abnormal_immune_serum1.81546548
41MP0009745_abnormal_behavioral_response1.81007082
42MP0003183_abnormal_peptide_metabolism1.80631870
43MP0002452_abnormal_antigen_presenting1.79479335
44MP0001800_abnormal_humoral_immune1.79273557
45MP0001790_abnormal_immune_system1.78260625
46MP0005387_immune_system_phenotype1.78260625
47MP0005408_hypopigmentation1.77178886
48MP0003635_abnormal_synaptic_transmissio1.74454752
49MP0005023_abnormal_wound_healing1.74372108
50MP0004859_abnormal_synaptic_plasticity1.70717939
51MP0003436_decreased_susceptibility_to1.70326398
52MP0001542_abnormal_bone_strength1.69040839
53MP0005501_abnormal_skin_physiology1.69030760
54MP0004264_abnormal_extraembryonic_tissu1.68488738
55MP0002166_altered_tumor_susceptibility1.66474998
56MP0002060_abnormal_skin_morphology1.63572069
57MP0006276_abnormal_autonomic_nervous1.59508294
58MP0005165_increased_susceptibility_to1.57968919
59MP0002064_seizures1.57316531
60MP0005464_abnormal_platelet_physiology1.56650912
61MP0002398_abnormal_bone_marrow1.56297357
62MP0001501_abnormal_sleep_pattern1.52720718
63MP0001853_heart_inflammation1.51594481
64MP0002822_catalepsy1.50194984
65MP0010155_abnormal_intestine_physiology1.49643043
66MP0001529_abnormal_vocalization1.49414543
67MP0002006_tumorigenesis1.48537881
68MP0002876_abnormal_thyroid_physiology1.46991105
69MP0000716_abnormal_immune_system1.46927533
70MP0001666_abnormal_nutrient_absorption1.46874117
71MP0009046_muscle_twitch1.44896781
72MP0001970_abnormal_pain_threshold1.44661064
73MP0010352_gastrointestinal_tract_polyps1.44334096
74MP0002396_abnormal_hematopoietic_system1.43762817
75MP0005174_abnormal_tail_pigmentation1.41995018
76MP0002572_abnormal_emotion/affect_behav1.40798452
77MP0005058_abnormal_lysosome_morphology1.40736944
78MP0002405_respiratory_system_inflammati1.39808775
79MP0003705_abnormal_hypodermis_morpholog1.39590337
80MP0009333_abnormal_splenocyte_physiolog1.38476181
81MP0009697_abnormal_copulation1.36837970
82MP0002063_abnormal_learning/memory/cond1.34508506
83MP0002733_abnormal_thermal_nociception1.33318045
84MP0001216_abnormal_epidermal_layer1.33285269
85MP0005085_abnormal_gallbladder_physiolo1.33257515
86MP0001881_abnormal_mammary_gland1.32977782
87MP0005310_abnormal_salivary_gland1.32854770
88MP0005275_abnormal_skin_tensile1.30464219
89MP0001243_abnormal_dermal_layer1.28135624
90MP0003300_gastrointestinal_ulcer1.27627322
91MP0000858_altered_metastatic_potential1.25459325
92MP0008872_abnormal_physiological_respon1.24647176
93MP0003252_abnormal_bile_duct1.24399113
94MP0005164_abnormal_response_to1.24062878
95MP0001845_abnormal_inflammatory_respons1.23861388
96MP0000689_abnormal_spleen_morphology1.23762107
97MP0002722_abnormal_immune_system1.23481701
98MP0002272_abnormal_nervous_system1.22854214
99MP0005397_hematopoietic_system_phenotyp1.22535539
100MP0001545_abnormal_hematopoietic_system1.22535539
101MP0005084_abnormal_gallbladder_morpholo1.21864094
102MP0002734_abnormal_mechanical_nocicepti1.21690152
103MP0001663_abnormal_digestive_system1.21516782
104MP0002429_abnormal_blood_cell1.21424456
105MP0003879_abnormal_hair_cell1.17215145
106MP0010386_abnormal_urinary_bladder1.16013737
107MP0005365_abnormal_bile_salt1.15085227
108MP0003786_premature_aging1.14418450
109MP0009643_abnormal_urine_homeostasis1.13828379
110MP0000627_abnormal_mammary_gland1.10552245
111MP0004510_myositis1.08184299
112MP0004808_abnormal_hematopoietic_stem1.07268169
113MP0000465_gastrointestinal_hemorrhage1.07064756
114MP0003303_peritoneal_inflammation1.06866566
115MP0004883_abnormal_blood_vessel1.06489018
116MP0003448_altered_tumor_morphology1.05989824
117MP0000681_abnormal_thyroid_gland1.05406034
118MP0002132_abnormal_respiratory_system1.05062529
119MP0004019_abnormal_vitamin_homeostasis1.04921436
120MP0001727_abnormal_embryo_implantation1.03335617
121MP0006082_CNS_inflammation1.03033668
122MP0008004_abnormal_stomach_pH1.02901686
123MP0010771_integument_phenotype1.02008155
124MP0005167_abnormal_blood-brain_barrier1.00595305
125MP0001664_abnormal_digestion0.99246872
126MP0000343_altered_response_to0.99011034
127MP0006036_abnormal_mitochondrial_physio0.98929061
128MP0010678_abnormal_skin_adnexa0.98858088
129MP0001440_abnormal_grooming_behavior0.98629804
130MP0003453_abnormal_keratinocyte_physiol0.97538176
131MP0004270_analgesia0.97519126
132MP0000015_abnormal_ear_pigmentation0.97320021
133MP0004782_abnormal_surfactant_physiolog0.97231738
134MP0001756_abnormal_urination0.96923799
135MP0004947_skin_inflammation0.95981973
136MP0003868_abnormal_feces_composition0.95839828
137MP0002067_abnormal_sensory_capabilities0.95281483
138MP0008260_abnormal_autophagy0.94930921
139MP0005409_darkened_coat_color0.94703471
140MP0004147_increased_porphyrin_level0.93338348
141MP0000358_abnormal_cell_content/0.92558636
142MP0000703_abnormal_thymus_morphology0.91961872
143MP0000490_abnormal_crypts_of0.91661261
144MP0005075_abnormal_melanosome_morpholog0.91170551
145MP0003279_aneurysm0.90144850
146MP0001533_abnormal_skeleton_physiology0.89780285
147MP0004957_abnormal_blastocyst_morpholog0.89504410
148MP0005332_abnormal_amino_acid0.88879580
149MP0005367_renal/urinary_system_phenotyp0.88712990
150MP0000516_abnormal_urinary_system0.88712990
151MP0005257_abnormal_intraocular_pressure0.87823323
152MP0002095_abnormal_skin_pigmentation0.87289155
153MP0005319_abnormal_enzyme/_coenzyme0.87277054
154MP0000013_abnormal_adipose_tissue0.86908735
155MP0001958_emphysema0.85901615
156MP0001984_abnormal_olfaction0.85404513
157MP0002909_abnormal_adrenal_gland0.84472285
158MP0003638_abnormal_response/metabolism_0.83855556
159MP0005166_decreased_susceptibility_to0.82877762
160MP0008469_abnormal_protein_level0.82293708
161MP0003075_altered_response_to0.81495866
162MP0008569_lethality_at_weaning0.80592672
163MP0000538_abnormal_urinary_bladder0.80254425
164MP0002136_abnormal_kidney_physiology0.80188583
165MP0005636_abnormal_mineral_homeostasis0.80042119
166MP0002098_abnormal_vibrissa_morphology0.77007984
167MP0003091_abnormal_cell_migration0.76736892

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.19820706
2Acute necrotizing encephalopathy (HP:0006965)4.15511969
3Abnormal mitochondria in muscle tissue (HP:0008316)3.98698204
4Recurrent abscess formation (HP:0002722)3.93584329
5Hepatocellular necrosis (HP:0001404)3.88187931
6Elevated erythrocyte sedimentation rate (HP:0003565)3.70183706
7Myositis (HP:0100614)3.56885905
8Progressive macrocephaly (HP:0004481)3.53662291
9IgM deficiency (HP:0002850)3.52185085
10Increased CSF lactate (HP:0002490)3.44935067
11Focal motor seizures (HP:0011153)3.33162305
12Abnormality of placental membranes (HP:0011409)3.29123415
13Amniotic constriction ring (HP:0009775)3.29123415
14Thrombocytosis (HP:0001894)3.16275400
15Eczematoid dermatitis (HP:0000976)3.16053684
16Vascular calcification (HP:0004934)3.12477512
17Recurrent bacterial skin infections (HP:0005406)3.10941792
18Cardiovascular calcification (HP:0011915)3.10035498
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08376858
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08376858
21Aplastic anemia (HP:0001915)3.05455327
22Hypothermia (HP:0002045)3.03576496
23Hepatic necrosis (HP:0002605)2.99515822
24Acute encephalopathy (HP:0006846)2.97968465
25Abnormal hair whorl (HP:0010721)2.97666602
26Abnormality of cells of the erythroid lineage (HP:0012130)2.97386536
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.96126318
28Obstructive lung disease (HP:0006536)2.94389736
29Chronic obstructive pulmonary disease (HP:0006510)2.94389736
30Premature rupture of membranes (HP:0001788)2.90193067
31Congenital ichthyosiform erythroderma (HP:0007431)2.88607130
32Increased hepatocellular lipid droplets (HP:0006565)2.88072170
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84338440
34Abnormal number of erythroid precursors (HP:0012131)2.82315998
35Vertebral compression fractures (HP:0002953)2.82062932
36Optic neuritis (HP:0100653)2.76431522
37Retrobulbar optic neuritis (HP:0100654)2.76431522
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76013458
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.71037744
40Osteolytic defects of the hand bones (HP:0009699)2.71037744
41Petechiae (HP:0000967)2.69779659
42Distal lower limb muscle weakness (HP:0009053)2.62057342
43Atonic seizures (HP:0010819)2.57112661
44Orchitis (HP:0100796)2.56370971
45Micronodular cirrhosis (HP:0001413)2.55865310
46Mediastinal lymphadenopathy (HP:0100721)2.55721506
47Stomatitis (HP:0010280)2.55150850
48IgG deficiency (HP:0004315)2.54062628
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53978959
50Exertional dyspnea (HP:0002875)2.53902837
51Reduced subcutaneous adipose tissue (HP:0003758)2.53231889
52Renal Fanconi syndrome (HP:0001994)2.53229626
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51013976
54Hypokinesia (HP:0002375)2.49550276
55Increased intramyocellular lipid droplets (HP:0012240)2.49217547
56Popliteal pterygium (HP:0009756)2.49208405
57Meningitis (HP:0001287)2.47871057
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47622289
59Increased IgM level (HP:0003496)2.46759874
60Visual hallucinations (HP:0002367)2.44009745
61Sparse eyelashes (HP:0000653)2.42704916
62Myokymia (HP:0002411)2.41095412
63Abnormalities of placenta or umbilical cord (HP:0001194)2.40667063
64Onycholysis (HP:0001806)2.38549425
65Chronic otitis media (HP:0000389)2.37873085
66Lipid accumulation in hepatocytes (HP:0006561)2.36846029
67Interstitial pulmonary disease (HP:0006530)2.35661265
68Recurrent bronchitis (HP:0002837)2.35591823
69Exercise intolerance (HP:0003546)2.31799648
70Type I transferrin isoform profile (HP:0003642)2.31477157
71Abnormality of macrophages (HP:0004311)2.28676693
72Palpitations (HP:0001962)2.27303320
73Reticulocytopenia (HP:0001896)2.26965952
74Rough bone trabeculation (HP:0100670)2.26293114
75J-shaped sella turcica (HP:0002680)2.25914963
76Lactic acidosis (HP:0003128)2.25573618
77Respiratory failure (HP:0002878)2.25420136
78Optic disc pallor (HP:0000543)2.22959453
79Recurrent fungal infections (HP:0002841)2.22912210
80Right ventricular cardiomyopathy (HP:0011663)2.21858819
81Cervical subluxation (HP:0003308)2.21613584
82Abnormality of liposaccharide metabolism (HP:0010968)2.21272458
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.21272458
84Abnormality of glycolipid metabolism (HP:0010969)2.21272458
85Increased serum lactate (HP:0002151)2.17883681
863-Methylglutaconic aciduria (HP:0003535)2.16007702
87Vacuolated lymphocytes (HP:0001922)2.14981805
88Glucose intolerance (HP:0000833)2.14884081
89Cerebral edema (HP:0002181)2.13794660
90Type 2 muscle fiber atrophy (HP:0003554)2.13592050
91Abnormality of the nasal mucosa (HP:0000433)2.11690981
92Abnormality of the umbilical cord (HP:0010881)2.10961436
93Chronic sinusitis (HP:0011109)2.10798193
94Fat malabsorption (HP:0002630)2.10604968
95Conjunctival hamartoma (HP:0100780)2.10586024
96Poor suck (HP:0002033)2.10133965
97Steatorrhea (HP:0002570)2.08658808
98Epileptic encephalopathy (HP:0200134)2.07619612
99Progressive neurologic deterioration (HP:0002344)2.05795833
100Hyperventilation (HP:0002883)2.05261317
101Posterior subcapsular cataract (HP:0007787)2.05001254
102Abnormality of the anterior horn cell (HP:0006802)2.03340115
103Degeneration of anterior horn cells (HP:0002398)2.03340115
104Malnutrition (HP:0004395)2.03141844
105Respiratory difficulties (HP:0002880)2.03126477
106Nasal polyposis (HP:0100582)2.03041867
107Febrile seizures (HP:0002373)2.02845913
108Conjugated hyperbilirubinemia (HP:0002908)2.02090497
109Mitral stenosis (HP:0001718)2.01098331
110Increased muscle lipid content (HP:0009058)2.00462174
111Tetraparesis (HP:0002273)2.00302262
112Autoamputation (HP:0001218)1.98710511
113Vasculitis (HP:0002633)1.98372488
114Panhypogammaglobulinemia (HP:0003139)1.98283058
115Abnormality of proline metabolism (HP:0010907)1.97926440
116Hydroxyprolinuria (HP:0003080)1.97926440
117Vascular tortuosity (HP:0004948)1.97541569
118Spondylolisthesis (HP:0003302)1.97373692
119Keratoconjunctivitis sicca (HP:0001097)1.96980098
120Muscle fiber atrophy (HP:0100295)1.96802572
121Recurrent skin infections (HP:0001581)1.96732591
122Pili torti (HP:0003777)1.96627290
123Aortic dissection (HP:0002647)1.96102268
124Abnormality of the distal phalanges of the toes (HP:0010182)1.96011146
125Nail dystrophy (HP:0008404)1.95595467
126B lymphocytopenia (HP:0010976)1.95088774
127Abnormality of B cell number (HP:0010975)1.95088774
128Trismus (HP:0000211)1.94668879
129Abnormality of the prostate (HP:0008775)1.94594297
130Chronic diarrhea (HP:0002028)1.93719702
131Hemoptysis (HP:0002105)1.93415915
132Microglossia (HP:0000171)1.89456822
133Hypergammaglobulinemia (HP:0010702)1.89008242
134Arterial tortuosity (HP:0005116)1.88919904
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.87831463
136Oral leukoplakia (HP:0002745)1.87594393
137Prolonged bleeding time (HP:0003010)1.86874736
138Abnormal trabecular bone morphology (HP:0100671)1.86475045
139Neuroendocrine neoplasm (HP:0100634)1.86120602
140Alopecia of scalp (HP:0002293)1.85947122
141Generalized aminoaciduria (HP:0002909)1.85206375
142Agammaglobulinemia (HP:0004432)1.84347276
143Polyphagia (HP:0002591)1.82989212
144Pulmonary fibrosis (HP:0002206)1.82150540
145Progressive inability to walk (HP:0002505)1.82120299
146Keratoconjunctivitis (HP:0001096)1.81282092
147Neutropenia (HP:0001875)1.81226954
148Chronic mucocutaneous candidiasis (HP:0002728)1.81192880
149Recurrent cutaneous fungal infections (HP:0011370)1.81192880
150Oligomenorrhea (HP:0000876)1.81028167
151Reduced antithrombin III activity (HP:0001976)1.80851692
152Abnormal hair laboratory examination (HP:0003328)1.80090115
153Increased serum pyruvate (HP:0003542)1.79690177
154Pulmonary infiltrates (HP:0002113)1.79206270
155Inability to walk (HP:0002540)1.78985925
156Tongue fasciculations (HP:0001308)1.78649315
157Hypobetalipoproteinemia (HP:0003563)1.77494896
158Lethargy (HP:0001254)1.76983512
159Fasciculations (HP:0002380)1.76706602
160Encephalitis (HP:0002383)1.76330551
161Lymphopenia (HP:0001888)1.75452759
162Esophageal neoplasm (HP:0100751)1.74817336
163Neoplasm of head and neck (HP:0012288)1.74817336
164Abnormality of T cell physiology (HP:0011840)1.74255779
165Abnormality of T cells (HP:0002843)1.74145007
166Orthostatic hypotension (HP:0001278)1.73944527
167Emotional lability (HP:0000712)1.73361515
168Prolonged neonatal jaundice (HP:0006579)1.73222144
169Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71641758
170Protrusio acetabuli (HP:0003179)1.71460104
171Nausea (HP:0002018)1.71204111
172Entropion (HP:0000621)1.71102417
173Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69452461
174Abnormal protein N-linked glycosylation (HP:0012347)1.69452461
175Abnormal protein glycosylation (HP:0012346)1.69452461
176Abnormal glycosylation (HP:0012345)1.69452461
177Axonal loss (HP:0003447)1.69062876
178Single umbilical artery (HP:0001195)1.68936815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.33578482
2MST1R3.57866565
3CDK193.26516703
4SCYL23.17263462
5STK163.07081805
6CASK3.02780444
7TXK2.88626830
8RIPK42.73949122
9MAP4K12.47911558
10MST42.42904543
11MAP2K72.40885694
12SIK32.37291714
13PBK2.25705651
14VRK22.00118128
15PIM22.00099445
16TEC1.94462944
17GRK61.93304781
18TSSK61.87965983
19ZAP701.83843362
20ARAF1.81926752
21CCNB11.78929110
22NEK11.76748820
23MET1.70355430
24* MAP3K121.69788074
25IRAK41.64914982
26KDR1.64727857
27KIT1.63393982
28MAP3K31.63272259
29TRIM281.61057189
30SYK1.59854713
31BLK1.55325003
32FES1.53151461
33GRK51.51075231
34CAMKK21.46747312
35NME11.43936486
36ADRBK21.42340274
37ERBB31.40317868
38VRK11.37448352
39PTK21.33525475
40BTK1.30737439
41BMPR21.26312688
42TNIK1.24783021
43LMTK21.22193651
44MAP2K61.21683083
45ABL21.21340400
46TRPM71.20453377
47NTRK31.19854588
48MINK11.18435027
49* DAPK11.18425928
50IKBKE1.18187597
51MAP3K141.18022079
52PDK21.18006751
53TESK11.17147577
54GRK71.15386418
55TESK21.14617959
56PLK21.14226953
57ERBB41.11945466
58* PAK41.08974740
59EIF2AK31.05113114
60BMPR1B1.04651535
61DAPK21.03597913
62FER1.03242873
63MATK1.00984499
64CDK80.98906570
65NME20.98174822
66TBK10.98034588
67MAP3K40.95844724
68PIK3CA0.94903224
69TIE10.94587906
70STK100.94374191
71BCR0.94197517
72ITK0.92851286
73LCK0.90635866
74* ILK0.85173280
75LYN0.81346326
76PRKG20.80535293
77TNK20.80217642
78LIMK10.79451063
79MAP2K40.78070570
80EPHA40.76296807
81MAP3K130.76287581
82MUSK0.74845442
83MAP3K90.73473218
84PIK3CG0.73053077
85JAK30.72135623
86MAP3K110.71901722
87* MYLK0.71111383
88CAMK2B0.71066326
89ERN10.70552987
90TGFBR10.68518164
91PRKCI0.67854878
92ADRBK10.67787419
93PTK2B0.66536931
94CAMK2G0.65051691
95OXSR10.62307381
96EPHB10.62297072
97PAK10.61212496
98MAPK40.60759474
99PTK60.60061634
100CAMK2D0.58948047
101FLT30.58805238
102PRPF4B0.58617400
103MAPKAPK20.57604500
104MAP3K20.57374644
105CSF1R0.56762844
106MAP2K30.56140859
107TYK20.55853448
108PRKCD0.55529375
109LRRK20.55135268
110TAOK20.54933267
111JAK10.54880438
112STK390.53476270
113BUB10.53355112
114RAF10.53218371
115STK240.50760563
116FGR0.50011391
117YES10.49947471
118MAPKAPK50.49881744
119TGFBR20.49001426
120MAPK130.48851757
121EIF2AK20.48611593
122STK38L0.48546520
123IKBKB0.48117620
124CAMK2A0.47726527
125CAMK10.46923168
126EIF2AK10.46076937
127NEK60.45161131
128RPS6KA60.44267849
129PAK20.44009928
130EPHB20.43840973
131MAP2K10.43210808
132RPS6KB20.41873007
133HCK0.41862604
134MAPKAPK30.41229114
135RPS6KL10.40551611
136RPS6KC10.40551611
137ABL10.39744593
138IRAK30.39612050
139DMPK0.39549753
140SIK20.39255427
141CDK50.39141650
142PRKCE0.38261368
143TAOK30.37848809
144ACVR1B0.37678263
145SRPK10.36495065
146RPS6KA20.35716547
147FYN0.35017553
148MOS0.34888690
149BRSK20.33771155
150PDGFRA0.33409309
151MAP3K80.33208551
152* ROCK10.33097889
153CLK10.32970000
154IGF1R0.32650768
155PKN20.32648564
156RPS6KA40.32609748
157STK30.31884298
158EGFR0.29254053
159CSNK1G30.28136755
160BMX0.24735819
161LATS10.24334768
162NUAK10.23073766

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.74540847
2Sulfur metabolism_Homo sapiens_hsa009203.11512463
3Parkinsons disease_Homo sapiens_hsa050123.03465777
4Collecting duct acid secretion_Homo sapiens_hsa049663.00698816
5Proteasome_Homo sapiens_hsa030502.93400120
6Ribosome_Homo sapiens_hsa030102.86665488
7Synaptic vesicle cycle_Homo sapiens_hsa047212.48424791
8Alzheimers disease_Homo sapiens_hsa050102.39243724
9Glutathione metabolism_Homo sapiens_hsa004802.24906386
10Huntingtons disease_Homo sapiens_hsa050162.03230538
11Vibrio cholerae infection_Homo sapiens_hsa051102.02815701
12Rheumatoid arthritis_Homo sapiens_hsa053231.98099901
13Fatty acid elongation_Homo sapiens_hsa000621.91293754
14Nicotine addiction_Homo sapiens_hsa050331.85689304
15Primary immunodeficiency_Homo sapiens_hsa053401.85670201
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76485335
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.74564468
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.71652923
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71564974
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63948439
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63424932
22Chemical carcinogenesis_Homo sapiens_hsa052041.60999174
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59465725
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54522312
25Folate biosynthesis_Homo sapiens_hsa007901.53494452
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46507722
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46476700
28Allograft rejection_Homo sapiens_hsa053301.43701577
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41162537
30Leishmaniasis_Homo sapiens_hsa051401.39677059
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37002750
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.36401296
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34836556
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34566449
35Pentose phosphate pathway_Homo sapiens_hsa000301.32992357
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31506522
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31230140
38Graft-versus-host disease_Homo sapiens_hsa053321.30841657
39Protein export_Homo sapiens_hsa030601.28796949
40Galactose metabolism_Homo sapiens_hsa000521.27649371
41Phagosome_Homo sapiens_hsa041451.27566796
42Olfactory transduction_Homo sapiens_hsa047401.25640359
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25491385
44Hematopoietic cell lineage_Homo sapiens_hsa046401.20397877
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19894890
46Asthma_Homo sapiens_hsa053101.18491961
47Caffeine metabolism_Homo sapiens_hsa002321.17422305
48Fructose and mannose metabolism_Homo sapiens_hsa000511.13971425
49Salmonella infection_Homo sapiens_hsa051321.13840168
50Antigen processing and presentation_Homo sapiens_hsa046121.12641988
51Morphine addiction_Homo sapiens_hsa050321.11821117
52Shigellosis_Homo sapiens_hsa051311.11610899
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11312351
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.08580445
55Type I diabetes mellitus_Homo sapiens_hsa049401.08184317
56Phenylalanine metabolism_Homo sapiens_hsa003601.08081112
57RNA polymerase_Homo sapiens_hsa030201.07094913
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06769980
59Pertussis_Homo sapiens_hsa051331.06282666
60African trypanosomiasis_Homo sapiens_hsa051431.06094375
61Long-term potentiation_Homo sapiens_hsa047201.04081361
62Mineral absorption_Homo sapiens_hsa049781.03489223
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.01514074
64Circadian entrainment_Homo sapiens_hsa047130.99871754
65Amphetamine addiction_Homo sapiens_hsa050310.96778509
66T cell receptor signaling pathway_Homo sapiens_hsa046600.92752744
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92525402
68Retinol metabolism_Homo sapiens_hsa008300.92040919
69Sphingolipid metabolism_Homo sapiens_hsa006000.90535739
70Tuberculosis_Homo sapiens_hsa051520.89706196
71Dopaminergic synapse_Homo sapiens_hsa047280.89263825
72Tyrosine metabolism_Homo sapiens_hsa003500.89260156
73Serotonergic synapse_Homo sapiens_hsa047260.88819658
74Measles_Homo sapiens_hsa051620.87938326
75Taste transduction_Homo sapiens_hsa047420.87400270
76Other glycan degradation_Homo sapiens_hsa005110.87390951
77Starch and sucrose metabolism_Homo sapiens_hsa005000.87214694
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86889339
79Carbon metabolism_Homo sapiens_hsa012000.83163146
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82859318
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82674385
82GABAergic synapse_Homo sapiens_hsa047270.82503369
83Viral myocarditis_Homo sapiens_hsa054160.82377279
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80996358
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79732775
86Cardiac muscle contraction_Homo sapiens_hsa042600.79574224
87Salivary secretion_Homo sapiens_hsa049700.78567056
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77401063
89Osteoclast differentiation_Homo sapiens_hsa043800.76730657
90Autoimmune thyroid disease_Homo sapiens_hsa053200.73321591
91Pyruvate metabolism_Homo sapiens_hsa006200.73065078
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72382462
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71795335
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71470665
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70456251
96Chemokine signaling pathway_Homo sapiens_hsa040620.69297074
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69252405
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68614856
99Gastric acid secretion_Homo sapiens_hsa049710.67331689
100Legionellosis_Homo sapiens_hsa051340.67119109
101Fat digestion and absorption_Homo sapiens_hsa049750.66171375
102Renin secretion_Homo sapiens_hsa049240.63766871
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62166889
104Glutamatergic synapse_Homo sapiens_hsa047240.60739950
105Pyrimidine metabolism_Homo sapiens_hsa002400.59971921
106B cell receptor signaling pathway_Homo sapiens_hsa046620.59945936
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59825654
108Cholinergic synapse_Homo sapiens_hsa047250.58481898
109Metabolic pathways_Homo sapiens_hsa011000.58177832
110Endocytosis_Homo sapiens_hsa041440.57270275
111Phototransduction_Homo sapiens_hsa047440.57098556
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56675579
113Calcium signaling pathway_Homo sapiens_hsa040200.56420853
114Epstein-Barr virus infection_Homo sapiens_hsa051690.54835838
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54553304
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.54022538
117N-Glycan biosynthesis_Homo sapiens_hsa005100.52110935
118Vitamin digestion and absorption_Homo sapiens_hsa049770.52016893
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51618127
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51550187
121Nucleotide excision repair_Homo sapiens_hsa034200.50975286
122Long-term depression_Homo sapiens_hsa047300.50953654
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50478720
124Renin-angiotensin system_Homo sapiens_hsa046140.49911593
125* Leukocyte transendothelial migration_Homo sapiens_hsa046700.49720293
126DNA replication_Homo sapiens_hsa030300.48619118
127Regulation of autophagy_Homo sapiens_hsa041400.47072026
128Peroxisome_Homo sapiens_hsa041460.46315582
129Thyroid cancer_Homo sapiens_hsa052160.46190913
130Complement and coagulation cascades_Homo sapiens_hsa046100.45710362
131Influenza A_Homo sapiens_hsa051640.45566324
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45498505
133Purine metabolism_Homo sapiens_hsa002300.45335911
134Toxoplasmosis_Homo sapiens_hsa051450.42759620
135Arginine biosynthesis_Homo sapiens_hsa002200.42720060
136Oxytocin signaling pathway_Homo sapiens_hsa049210.42500802
137Biosynthesis of amino acids_Homo sapiens_hsa012300.42093016
138* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42006989
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.40757174
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40532333
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.39882868
142* Platelet activation_Homo sapiens_hsa046110.39838383
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39310328
144Hepatitis B_Homo sapiens_hsa051610.38792371
145Fatty acid degradation_Homo sapiens_hsa000710.38266007
146Spliceosome_Homo sapiens_hsa030400.37939648
147Lysosome_Homo sapiens_hsa041420.37764104
148Malaria_Homo sapiens_hsa051440.37513530
149* Focal adhesion_Homo sapiens_hsa045100.35908525
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.35795671
151Proteoglycans in cancer_Homo sapiens_hsa052050.35788511
152Cocaine addiction_Homo sapiens_hsa050300.34549812
153Tryptophan metabolism_Homo sapiens_hsa003800.33677150
154* Tight junction_Homo sapiens_hsa045300.33180954
155Sulfur relay system_Homo sapiens_hsa041220.30193104
156Arachidonic acid metabolism_Homo sapiens_hsa005900.28012916
157Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27475371
158Apoptosis_Homo sapiens_hsa042100.27033786
159p53 signaling pathway_Homo sapiens_hsa041150.25772503

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