ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	basic amino acid transport (GO:0015802)	5.22431005
2	regulation of isotype switching to IgG isotypes (GO:0048302)	4.63796562
3	DNA deamination (GO:0045006)	4.55707337
4	cytidine metabolic process (GO:0046087)	4.49005348
5	cytidine catabolic process (GO:0006216)	4.49005348
6	cytidine deamination (GO:0009972)	4.49005348
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.17023863
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.06780358
9	proteasome assembly (GO:0043248)	4.06345855
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.03840409
11	regulation of chronic inflammatory response (GO:0002676)	3.96221763
12	ATP synthesis coupled proton transport (GO:0015986)	3.90927025
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.90927025
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.89756206
15	preassembly of GPI anchor in ER membrane (GO:0016254)	3.87139782
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.75281503
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.75281503
18	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.74655994
19	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.73021761
20	electron transport chain (GO:0022900)	3.70564541
21	respiratory electron transport chain (GO:0022904)	3.70056393
22	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.67896243
23	protein neddylation (GO:0045116)	3.63287212
24	epithelial cilium movement (GO:0003351)	3.48396574
25	rRNA methylation (GO:0031167)	3.35919460
26	regulation of cellular amino acid metabolic process (GO:0006521)	3.26913281
27	rRNA modification (GO:0000154)	3.23316026
28	regulation of immunoglobulin secretion (GO:0051023)	3.19511945
29	protein complex biogenesis (GO:0070271)	3.14623295
30	axoneme assembly (GO:0035082)	3.10635267
31	piRNA metabolic process (GO:0034587)	3.08334688
32	regulation of thymocyte apoptotic process (GO:0070243)	3.06282318
33	S-adenosylmethionine metabolic process (GO:0046500)	3.03891537
34	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.01658544
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.00739306
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99450543
37	NADH dehydrogenase complex assembly (GO:0010257)	2.99450543
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99450543
39	regulation of glycogen (starch) synthase activity (GO:2000465)	2.98694362
40	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.98673424
41	alpha-beta T cell activation involved in immune response (GO:0002287)	2.98673424
42	T cell differentiation involved in immune response (GO:0002292)	2.98673424
43	negative regulation of thymocyte apoptotic process (GO:0070244)	2.98592468
44	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.92651459
45	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.88355077
46	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.88355077
47	negative regulation of T cell differentiation in thymus (GO:0033085)	2.88066042
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85787226
49	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.85541157
50	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.85541157
51	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.85541157
52	positive regulation of calcium-mediated signaling (GO:0050850)	2.83368583
53	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.83326774
54	response to pheromone (GO:0019236)	2.83082668
55	positive regulation of T cell cytokine production (GO:0002726)	2.82347930
56	GPI anchor biosynthetic process (GO:0006506)	2.81680583
57	cysteine metabolic process (GO:0006534)	2.81545528
58	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.81246555
59	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.80631366
60	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.80094455
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.78566089
62	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.78148284
63	GPI anchor metabolic process (GO:0006505)	2.77395898
64	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.77155428
65	positive regulation of defense response to virus by host (GO:0002230)	2.76783746
66	sequestering of actin monomers (GO:0042989)	2.74258726
67	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.73824982
68	protein-cofactor linkage (GO:0018065)	2.73114764
69	hydrogen ion transmembrane transport (GO:1902600)	2.72173918
70	adenosine metabolic process (GO:0046085)	2.70769039
71	response to xenobiotic stimulus (GO:0009410)	2.69399379
72	chaperone-mediated protein transport (GO:0072321)	2.67567558
73	respiratory chain complex IV assembly (GO:0008535)	2.67430859
74	negative regulation of ligase activity (GO:0051352)	2.66903080
75	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66903080
76	cilium movement (GO:0003341)	2.66629613
77	proton transport (GO:0015992)	2.66147712
78	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.65619228
79	T-helper cell differentiation (GO:0042093)	2.65619228
80	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.65099788
81	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.65099788
82	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.64408953
83	axonemal dynein complex assembly (GO:0070286)	2.64160583
84	alpha-beta T cell differentiation (GO:0046632)	2.63110751
85	C-terminal protein lipidation (GO:0006501)	2.61848847
86	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.61172733
87	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.61049774
88	behavioral response to nicotine (GO:0035095)	2.60876013
89	hydrogen transport (GO:0006818)	2.60627563
90	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.60129024
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.59492894
92	actin nucleation (GO:0045010)	2.58618224
93	regulation of T cell mediated cytotoxicity (GO:0001914)	2.58128459
94	positive regulation of prostaglandin secretion (GO:0032308)	2.55292486
95	mannosylation (GO:0097502)	2.52416280
96	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.52156025
97	positive regulation of chemokine biosynthetic process (GO:0045080)	2.51337939
98	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.51327123
99	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.51100640
100	L-fucose metabolic process (GO:0042354)	2.50540577

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.97065052
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.09359121
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.96214352
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.77080146
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.64008388
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.62667791
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.61095824
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.60848981
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.60276108
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60009135
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.59843131
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50108956
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.43165662
14	VDR_22108803_ChIP-Seq_LS180_Human	2.31710459
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20456599
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.16161979
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.01561946
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01143487
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01044277
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.91257674
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.89068968
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.82492508
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.82043981
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81246089
25	EWS_26573619_Chip-Seq_HEK293_Human	1.80294032
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.72388378
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.72115845
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69729389
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68347746
30	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.67096589
31	P300_19829295_ChIP-Seq_ESCs_Human	1.66445780
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63973598
33	GATA3_26560356_Chip-Seq_TH2_Human	1.54977824
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54485690
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.54428977
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54123520
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54123520
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52500757
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49412000
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.46428219
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44217953
42	FUS_26573619_Chip-Seq_HEK293_Human	1.43736801
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.43726096
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40698144
45	IGF1R_20145208_ChIP-Seq_DFB_Human	1.39616729
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39479617
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39479617
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38537312
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.38504723
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38306986
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33940758
52	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.33557222
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31328920
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28511347
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.28511347
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.27640751
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26842755
58	MYB_26560356_Chip-Seq_TH2_Human	1.25324144
59	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.25286039
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24410035
61	AR_20517297_ChIP-Seq_VCAP_Human	1.21910271
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.21487391
63	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20891157
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19254997
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18107954
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.17904980
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.17871531
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.17785169
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17737630
70	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.17731881
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17705483
72	NCOR_22424771_ChIP-Seq_293T_Human	1.17520886
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17206817
74	PHF8_20622853_ChIP-Seq_HELA_Human	1.17135967
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14891194
76	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14709841
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13492142
78	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12642933
79	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.12516873
80	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10505393
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09925268
82	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09171139
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.08993878
84	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.07970643
85	HTT_18923047_ChIP-ChIP_STHdh_Human	1.07491960
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06277472
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06178182
88	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05632042
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04751295
90	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02612251
91	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.01753480
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.01669773
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01228960
94	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00904368
95	GATA3_27048872_Chip-Seq_THYMUS_Human	1.00811378
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99537680
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99211155
98	NFYB_21822215_ChIP-Seq_K562_Human	0.98732653
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.98610589
100	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.97543733

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.35412307
2	MP0001835_abnormal_antigen_presentation	3.47890494
3	MP0009785_altered_susceptibility_to	2.84684701
4	MP0008875_abnormal_xenobiotic_pharmacok	2.65021310
5	MP0008872_abnormal_physiological_respon	2.49022332
6	MP0005084_abnormal_gallbladder_morpholo	2.41815846
7	MP0001873_stomach_inflammation	2.32694160
8	MP0001986_abnormal_taste_sensitivity	2.32515977
9	MP0005387_immune_system_phenotype	2.27166958
10	MP0001790_abnormal_immune_system	2.27166958
11	MP0002837_dystrophic_cardiac_calcinosis	2.21609060
12	MP0004885_abnormal_endolymph	2.02531872
13	MP0002163_abnormal_gland_morphology	2.00292378
14	MP0000685_abnormal_immune_system	1.97024859
15	MP0001800_abnormal_humoral_immune	1.95891041
16	MP0000372_irregular_coat_pigmentation	1.91767571
17	MP0005000_abnormal_immune_tolerance	1.88720744
18	MP0001968_abnormal_touch/_nociception	1.87194845
19	MP0003136_yellow_coat_color	1.84299643
20	MP0003763_abnormal_thymus_physiology	1.83412294
21	MP0001984_abnormal_olfaction	1.80791118
22	MP0002138_abnormal_hepatobiliary_system	1.72547361
23	MP0002277_abnormal_respiratory_mucosa	1.71376535
24	MP0005379_endocrine/exocrine_gland_phen	1.69476428
25	MP0002102_abnormal_ear_morphology	1.66627721
26	MP0001188_hyperpigmentation	1.64675973
27	MP0009333_abnormal_splenocyte_physiolog	1.64042197
28	MP0003646_muscle_fatigue	1.62027710
29	MP0002723_abnormal_immune_serum	1.61551680
30	MP0002148_abnormal_hypersensitivity_rea	1.58896739
31	MP0002876_abnormal_thyroid_physiology	1.55909893
32	MP0006072_abnormal_retinal_apoptosis	1.54201987
33	MP0005075_abnormal_melanosome_morpholog	1.53597161
34	MP0004142_abnormal_muscle_tone	1.52679640
35	MP0006054_spinal_hemorrhage	1.51113012
36	MP0005645_abnormal_hypothalamus_physiol	1.49852691
37	MP0003806_abnormal_nucleotide_metabolis	1.44561359
38	MP0002452_abnormal_antigen_presenting	1.43981018
39	MP0002166_altered_tumor_susceptibility	1.43383499
40	MP0001501_abnormal_sleep_pattern	1.40948031
41	MP0001819_abnormal_immune_cell	1.37483266
42	MP0002420_abnormal_adaptive_immunity	1.36848572
43	MP0001756_abnormal_urination	1.36454762
44	MP0004145_abnormal_muscle_electrophysio	1.36014833
45	MP0003866_abnormal_defecation	1.35872020
46	MP0006082_CNS_inflammation	1.35712471
47	MP0002006_tumorigenesis	1.35675679
48	MP0002933_joint_inflammation	1.35564849
49	MP0009764_decreased_sensitivity_to	1.32771904
50	MP0003011_delayed_dark_adaptation	1.30023501
51	MP0005025_abnormal_response_to	1.28683505
52	MP0004147_increased_porphyrin_level	1.27406318
53	MP0001348_abnormal_lacrimal_gland	1.24707735
54	MP0003252_abnormal_bile_duct	1.20502717
55	MP0005174_abnormal_tail_pigmentation	1.17130327
56	MP0005646_abnormal_pituitary_gland	1.16883387
57	MP0002405_respiratory_system_inflammati	1.15619332
58	MP0003186_abnormal_redox_activity	1.13569089
59	MP0000015_abnormal_ear_pigmentation	1.11825278
60	MP0010155_abnormal_intestine_physiology	1.10383535
61	MP0002693_abnormal_pancreas_physiology	1.07809076
62	MP0006276_abnormal_autonomic_nervous	1.07512886
63	MP0005551_abnormal_eye_electrophysiolog	1.06119424
64	MP0002272_abnormal_nervous_system	1.05896115
65	MP0001881_abnormal_mammary_gland	1.05840168
66	MP0001845_abnormal_inflammatory_respons	1.04986658
67	MP0002736_abnormal_nociception_after	1.04448544
68	MP0010368_abnormal_lymphatic_system	1.03156351
69	MP0001485_abnormal_pinna_reflex	1.02984835
70	MP0001502_abnormal_circadian_rhythm	1.00910570
71	MP0008877_abnormal_DNA_methylation	1.00449164
72	MP0003195_calcinosis	0.99359233
73	MP0006035_abnormal_mitochondrial_morpho	0.97101960
74	MP0001970_abnormal_pain_threshold	0.96497036
75	MP0003638_abnormal_response/metabolism_	0.94372939
76	MP0002909_abnormal_adrenal_gland	0.92364503
77	MP0010386_abnormal_urinary_bladder	0.92213424
78	MP0000716_abnormal_immune_system	0.91615578
79	MP0004381_abnormal_hair_follicle	0.91326098
80	MP0001905_abnormal_dopamine_level	0.88820900
81	MP0003724_increased_susceptibility_to	0.88600741
82	MP0004134_abnormal_chest_morphology	0.88010508
83	MP0009745_abnormal_behavioral_response	0.86988907
84	MP0001919_abnormal_reproductive_system	0.86791313
85	MP0000230_abnormal_systemic_arterial	0.86544609
86	MP0003718_maternal_effect	0.85673674
87	MP0005389_reproductive_system_phenotype	0.85202157
88	MP0004742_abnormal_vestibular_system	0.85193997
89	MP0001879_abnormal_lymphatic_vessel	0.83757746
90	MP0002398_abnormal_bone_marrow	0.83745630
91	MP0005377_hearing/vestibular/ear_phenot	0.83568075
92	MP0003878_abnormal_ear_physiology	0.83568075
93	MP0002928_abnormal_bile_duct	0.82081372
94	MP0004084_abnormal_cardiac_muscle	0.81126755
95	MP0005408_hypopigmentation	0.80904076
96	MP0005166_decreased_susceptibility_to	0.79809598
97	MP0003943_abnormal_hepatobiliary_system	0.79471348
98	MP0008469_abnormal_protein_level	0.79175040
99	MP0002733_abnormal_thermal_nociception	0.79128039
100	MP0004215_abnormal_myocardial_fiber	0.78360142

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	3.83545952
2	IgG deficiency (HP:0004315)	3.82516796
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.77389756
4	Absent/shortened dynein arms (HP:0200106)	3.77389756
5	Mitochondrial inheritance (HP:0001427)	3.72563709
6	Increased CSF lactate (HP:0002490)	3.66586138
7	Lipid accumulation in hepatocytes (HP:0006561)	3.61889361
8	Abnormality of B cell number (HP:0010975)	3.60021300
9	Aplastic anemia (HP:0001915)	3.38036990
10	Type II lissencephaly (HP:0007260)	3.37895525
11	B lymphocytopenia (HP:0010976)	3.34740849
12	Acute necrotizing encephalopathy (HP:0006965)	3.32131630
13	Increased IgM level (HP:0003496)	3.25288135
14	Hypoproteinemia (HP:0003075)	3.24501264
15	Congenital, generalized hypertrichosis (HP:0004540)	3.14131795
16	Renal Fanconi syndrome (HP:0001994)	3.08763482
17	Progressive macrocephaly (HP:0004481)	3.01954340
18	Abnormal ciliary motility (HP:0012262)	2.98742305
19	Autoimmune hemolytic anemia (HP:0001890)	2.98495529
20	Acute encephalopathy (HP:0006846)	2.97911698
21	Abnormality of midbrain morphology (HP:0002418)	2.96392379
22	Molar tooth sign on MRI (HP:0002419)	2.96392379
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.94126493
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.94126493
25	Hypothermia (HP:0002045)	2.93817000
26	Exertional dyspnea (HP:0002875)	2.91466676
27	Stomatitis (HP:0010280)	2.90455848
28	Severe combined immunodeficiency (HP:0004430)	2.88886429
29	Hepatocellular necrosis (HP:0001404)	2.88012367
30	Pancreatic cysts (HP:0001737)	2.86761646
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.78855041
32	Nephronophthisis (HP:0000090)	2.70903904
33	Abnormality of T cell number (HP:0011839)	2.63724907
34	Hemoptysis (HP:0002105)	2.60897397
35	3-Methylglutaconic aciduria (HP:0003535)	2.57070613
36	Optic disc pallor (HP:0000543)	2.55917776
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.54899576
38	Increased intramyocellular lipid droplets (HP:0012240)	2.54222862
39	Hepatic necrosis (HP:0002605)	2.49705998
40	Increased serum lactate (HP:0002151)	2.48525053
41	T lymphocytopenia (HP:0005403)	2.44127232
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.43509539
43	Thyroiditis (HP:0100646)	2.41909981
44	Cerebral palsy (HP:0100021)	2.34970034
45	Attenuation of retinal blood vessels (HP:0007843)	2.34823260
46	Constricted visual fields (HP:0001133)	2.32546603
47	Abnormality of T cells (HP:0002843)	2.29996227
48	Congenital stationary night blindness (HP:0007642)	2.28609045
49	Elevated erythrocyte sedimentation rate (HP:0003565)	2.27080435
50	Glycosuria (HP:0003076)	2.25690125
51	Abnormality of urine glucose concentration (HP:0011016)	2.25690125
52	Amniotic constriction ring (HP:0009775)	2.24815078
53	Abnormality of placental membranes (HP:0011409)	2.24815078
54	Recurrent bronchitis (HP:0002837)	2.21061643
55	Chronic sinusitis (HP:0011109)	2.19160306
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.16977239
57	Increased muscle lipid content (HP:0009058)	2.16428798
58	Combined immunodeficiency (HP:0005387)	2.15946528
59	Recurrent cutaneous fungal infections (HP:0011370)	2.14575440
60	Chronic mucocutaneous candidiasis (HP:0002728)	2.14575440
61	Abnormality of the renal cortex (HP:0011035)	2.13885770
62	Methylmalonic acidemia (HP:0002912)	2.13126319
63	Abnormality of the renal medulla (HP:0100957)	2.12183219
64	Cerebral edema (HP:0002181)	2.12108222
65	Oral leukoplakia (HP:0002745)	2.10634809
66	True hermaphroditism (HP:0010459)	2.08711548
67	Large for gestational age (HP:0001520)	2.07350440
68	Hypoalbuminemia (HP:0003073)	2.04141688
69	Abnormal albumin level (HP:0012116)	2.04141688
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.03952677
71	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03713294
72	Facial diplegia (HP:0001349)	2.01539704
73	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99869596
74	Abnormality of eosinophils (HP:0001879)	1.98403845
75	Abnormality of T cell physiology (HP:0011840)	1.97951852
76	Pancreatic fibrosis (HP:0100732)	1.97117197
77	Bile duct proliferation (HP:0001408)	1.95743408
78	Abnormal biliary tract physiology (HP:0012439)	1.95743408
79	Conjunctival hamartoma (HP:0100780)	1.95358410
80	Bronchiectasis (HP:0002110)	1.94986372
81	Fatigue (HP:0012378)	1.93231137
82	Retrobulbar optic neuritis (HP:0100654)	1.92651718
83	Optic neuritis (HP:0100653)	1.92651718
84	Abnormality of renal resorption (HP:0011038)	1.91820298
85	Pulmonary infiltrates (HP:0002113)	1.90519853
86	Pendular nystagmus (HP:0012043)	1.90397428
87	Bronchitis (HP:0012387)	1.90324072
88	Lactic acidosis (HP:0003128)	1.89253015
89	Abnormality of the prostate (HP:0008775)	1.89029798
90	Short tibia (HP:0005736)	1.88273207
91	Cerebellar dysplasia (HP:0007033)	1.83450943
92	Azoospermia (HP:0000027)	1.82198698
93	Eosinophilia (HP:0001880)	1.82192119
94	Palpitations (HP:0001962)	1.81319645
95	Autoimmune thrombocytopenia (HP:0001973)	1.79668000
96	Renal cortical cysts (HP:0000803)	1.77786172
97	Exercise intolerance (HP:0003546)	1.75544425
98	Rhinitis (HP:0012384)	1.72752966
99	Tongue fasciculations (HP:0001308)	1.71778633
100	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.71276786

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K11	2.89405627
2	TXK	2.42183059
3	MYLK	2.37028269
4	ADRBK2	2.17216948
5	VRK2	2.15673601
6	MAP3K9	2.10971970
7	MAP3K12	10.7475447
8	NUAK1	1.94304619
9	GRK1	1.81197890
10	TSSK6	1.76195185
11	WNK3	1.65549349
12	FRK	1.63436825
13	TLK1	1.63067401
14	TAOK3	1.54308771
15	KDR	1.52850575
16	MST4	1.44270488
17	BCKDK	1.44202219
18	TRIM28	1.31902294
19	STK16	1.29867036
20	MAP4K2	1.28191475
21	NEK1	1.27614203
22	TAF1	1.27185379
23	VRK1	1.23816054
24	DAPK1	1.14777443
25	MAP2K6	1.08638983
26	TIE1	1.02115543
27	MAP2K4	0.98703436
28	MAP3K5	0.93614644
29	MAP4K1	0.91370218
30	ILK	0.90892807
31	EIF2AK3	0.90414198
32	BMPR2	0.86733525
33	ARAF	0.86256716
34	ITK	0.86203635
35	ZAK	0.84779368
36	GRK7	0.81296032
37	FES	0.80179867
38	OXSR1	0.80088151
39	CSNK1G1	0.78495966
40	LIMK1	0.76925685
41	ACVR1B	0.76278678
42	PHKG1	0.75346377
43	PHKG2	0.75346377
44	ERBB3	0.73420470
45	IKBKB	0.68701897
46	CSNK1G3	0.68424928
47	BMPR1B	0.67552416
48	MAP3K13	0.66908612
49	DAPK3	0.66529490
50	ROCK1	0.65558312
51	DAPK2	0.64583444
52	BUB1	0.64571457
53	EIF2AK2	0.63415614
54	MAPK13	0.63304161
55	TEC	0.62603132
56	PLK3	0.59738481
57	CSNK1G2	0.57530520
58	RIPK4	0.57342183
59	STK24	0.55829831
60	SYK	0.54888941
61	PRKCQ	0.54046051
62	DYRK2	0.51183513
63	MARK3	0.51148327
64	KSR1	0.49816317
65	BCR	0.49619189
66	BTK	0.47564483
67	JAK3	0.47525754
68	PRKCI	0.47352646
69	MUSK	0.46556981
70	PAK4	0.46132933
71	CSNK1A1L	0.45394424
72	GRK6	0.45016584
73	CDK19	0.44556894
74	FLT3	0.44407911
75	PIK3CA	0.43993253
76	GRK5	0.43923914
77	ADRBK1	0.42646251
78	SRPK1	0.42157630
79	PRKCG	0.41831972
80	STK39	0.41690412
81	PINK1	0.41647907
82	INSRR	0.41097941
83	CAMK2A	0.40715961
84	PTK2B	0.39197308
85	LCK	0.39065534
86	MOS	0.39033405
87	CSF1R	0.37329990
88	WNK4	0.36978829
89	CSK	0.36501203
90	EIF2AK1	0.36467482
91	TRPM7	0.36331674
92	NME1	0.35959059
93	TESK1	0.34892594
94	STK38L	0.33085524
95	PRKCE	0.32490371
96	PRKCA	0.31725380
97	KIT	0.31314624
98	PIM1	0.30699168
99	CDK8	0.27265056
100	PRKACA	0.26830386

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.19113338
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.55745711
3	Asthma_Homo sapiens_hsa05310	3.45221358
4	Allograft rejection_Homo sapiens_hsa05330	3.42269756
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.16909024
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.15083665
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.96411754
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.93802339
9	Parkinsons disease_Homo sapiens_hsa05012	2.93042093
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.89697086
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.70828534
12	Protein export_Homo sapiens_hsa03060	2.60092044
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.42664938
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.23553030
15	Alzheimers disease_Homo sapiens_hsa05010	2.00497726
16	Huntingtons disease_Homo sapiens_hsa05016	1.79853929
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.74975190
18	RNA polymerase_Homo sapiens_hsa03020	1.66464441
19	Basal transcription factors_Homo sapiens_hsa03022	1.57015201
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54493715
21	Phototransduction_Homo sapiens_hsa04744	1.41256131
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.40557344
23	Caffeine metabolism_Homo sapiens_hsa00232	1.35233222
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34696129
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33453322
26	Ribosome_Homo sapiens_hsa03010	1.28236192
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.23896674
28	Homologous recombination_Homo sapiens_hsa03440	1.22028494
29	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13066934
30	Nicotine addiction_Homo sapiens_hsa05033	1.10025422
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.07280912
32	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.06977744
33	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.04933977
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01570784
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96488834
36	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87987851
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86223898
38	Viral myocarditis_Homo sapiens_hsa05416	0.86167599
39	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85989270
40	RNA degradation_Homo sapiens_hsa03018	0.84209647
41	Selenocompound metabolism_Homo sapiens_hsa00450	0.82786982
42	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.82771623
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80879941
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78949830
45	Purine metabolism_Homo sapiens_hsa00230	0.78698370
46	Butanoate metabolism_Homo sapiens_hsa00650	0.78617880
47	Propanoate metabolism_Homo sapiens_hsa00640	0.78212728
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78027140
49	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.77657546
50	One carbon pool by folate_Homo sapiens_hsa00670	0.73370445
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73263187
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72254147
53	Sulfur metabolism_Homo sapiens_hsa00920	0.70275522
54	Peroxisome_Homo sapiens_hsa04146	0.69569849
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61840299
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61556327
57	Olfactory transduction_Homo sapiens_hsa04740	0.60058226
58	Retinol metabolism_Homo sapiens_hsa00830	0.58791304
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55790873
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53051261
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51316224
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51179637
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50782656
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50076424
65	Morphine addiction_Homo sapiens_hsa05032	0.48950162
66	Measles_Homo sapiens_hsa05162	0.48761755
67	Glutathione metabolism_Homo sapiens_hsa00480	0.48190983
68	Leishmaniasis_Homo sapiens_hsa05140	0.46887045
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46589014
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46223533
71	African trypanosomiasis_Homo sapiens_hsa05143	0.45827092
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.44750762
73	Metabolic pathways_Homo sapiens_hsa01100	0.44177322
74	RNA transport_Homo sapiens_hsa03013	0.42540353
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.41928100
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39721864
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39443143
78	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38957425
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.37512977
80	Legionellosis_Homo sapiens_hsa05134	0.37025457
81	Taste transduction_Homo sapiens_hsa04742	0.36382892
82	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.36265691
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33894310
84	Serotonergic synapse_Homo sapiens_hsa04726	0.33798406
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32822965
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32787053
87	Folate biosynthesis_Homo sapiens_hsa00790	0.32649425
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31519085
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.31163295
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31154532
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.30483019
92	Regulation of autophagy_Homo sapiens_hsa04140	0.29610826
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29359617
94	Malaria_Homo sapiens_hsa05144	0.29298199
95	Fanconi anemia pathway_Homo sapiens_hsa03460	0.27068981
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.24993043
97	GABAergic synapse_Homo sapiens_hsa04727	0.24825831
98	Herpes simplex infection_Homo sapiens_hsa05168	0.22260032
99	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.21462944
100	Circadian rhythm_Homo sapiens_hsa04710	0.21069114

MYL12BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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