MYL12BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)9.32571351
2growth hormone receptor signaling pathway (GO:0060396)7.55895592
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.42193052
4cellular response to growth hormone stimulus (GO:0071378)6.70662379
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.61639218
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.23502174
7regulation of podosome assembly (GO:0071801)5.97727323
8negative regulation of T-helper cell differentiation (GO:0045623)5.44578142
9negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.44578142
10negative regulation of mast cell activation (GO:0033004)5.20894178
11regulation of isotype switching to IgG isotypes (GO:0048302)4.99654870
12alpha-beta T cell differentiation involved in immune response (GO:0002293)4.86487955
13alpha-beta T cell activation involved in immune response (GO:0002287)4.86487955
14T cell differentiation involved in immune response (GO:0002292)4.86487955
15cellular response to interleukin-15 (GO:0071350)4.81930444
16T-helper cell differentiation (GO:0042093)4.58391731
17CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.58391731
18T cell lineage commitment (GO:0002360)4.53008896
19positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.51602351
20negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.47869166
21response to interleukin-15 (GO:0070672)4.47647494
22regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.47480762
23regulation of MHC class II biosynthetic process (GO:0045346)4.01837876
24regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.99168676
25regulation of interleukin-13 production (GO:0032656)3.98852695
26positive regulation of isotype switching (GO:0045830)3.96285002
27positive regulation of DNA recombination (GO:0045911)3.94538538
28defense response to protozoan (GO:0042832)3.93276422
29negative regulation of alpha-beta T cell differentiation (GO:0046639)3.88010675
30positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.85427830
31response to protozoan (GO:0001562)3.82951082
32DNA deamination (GO:0045006)3.81919961
33positive regulation of immunoglobulin production (GO:0002639)3.68377228
34positive regulation of chemokine biosynthetic process (GO:0045080)3.63112131
35JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.59781986
36regulation of T-helper cell differentiation (GO:0045622)3.55225415
37cytidine deamination (GO:0009972)3.53913382
38cytidine metabolic process (GO:0046087)3.53913382
39cytidine catabolic process (GO:0006216)3.53913382
40positive regulation of granulocyte differentiation (GO:0030854)3.52683985
41regulation of chronic inflammatory response (GO:0002676)3.50394567
42regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.47739146
43regulation of interleukin-6 biosynthetic process (GO:0045408)3.46231674
44negative regulation of acute inflammatory response (GO:0002674)3.41636995
45response to growth hormone (GO:0060416)3.39235920
46positive regulation of B cell proliferation (GO:0030890)3.34071291
47lung lobe morphogenesis (GO:0060463)3.29609478
48regulation of immunoglobulin secretion (GO:0051023)3.27837423
49interferon-gamma secretion (GO:0072643)3.25891535
50regulation of B cell receptor signaling pathway (GO:0050855)3.22907769
51interferon-gamma production (GO:0032609)3.19912470
52positive regulation of organelle assembly (GO:1902117)3.17548551
53regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.12276697
54negative regulation of alpha-beta T cell activation (GO:0046636)3.10127440
55positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.09682823
56alpha-beta T cell differentiation (GO:0046632)3.07979795
57T cell activation involved in immune response (GO:0002286)3.03290100
58CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.02228554
59positive regulation of JAK-STAT cascade (GO:0046427)3.02040602
60regulation of B cell proliferation (GO:0030888)2.99886993
61CD4-positive, alpha-beta T cell activation (GO:0035710)2.99411932
62synapsis (GO:0007129)2.98333020
63regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.93152365
64positive regulation of receptor internalization (GO:0002092)2.92910191
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91558231
66pyrimidine ribonucleoside catabolic process (GO:0046133)2.90591242
67alpha-beta T cell activation (GO:0046631)2.90406157
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87612148
69positive regulation of immunoglobulin mediated immune response (GO:0002891)2.85847817
70positive regulation of B cell mediated immunity (GO:0002714)2.85847817
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.84223938
72interferon-gamma-mediated signaling pathway (GO:0060333)2.81454091
73positive regulation of interleukin-12 production (GO:0032735)2.80031685
74positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.79608698
75cytokine biosynthetic process (GO:0042089)2.79512008
76positive regulation of interleukin-10 production (GO:0032733)2.78628565
77regulation of triglyceride catabolic process (GO:0010896)2.78254458
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76143817
79lymphocyte costimulation (GO:0031294)2.74242611
80negative regulation of adaptive immune response (GO:0002820)2.73754262
81hepatocyte apoptotic process (GO:0097284)2.70440675
82nucleotide transmembrane transport (GO:1901679)2.69183200
83regulation of hypersensitivity (GO:0002883)2.69004725
84positive regulation of B cell activation (GO:0050871)2.66099569
85negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.65798405
86regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.65576677
87negative T cell selection (GO:0043383)2.62679504
88respiratory chain complex IV assembly (GO:0008535)2.62344123
89T cell migration (GO:0072678)2.62240447
90respiratory tube development (GO:0030323)2.62148266
91positive regulation of activated T cell proliferation (GO:0042104)2.61543571
92positive regulation of cytokine biosynthetic process (GO:0042108)2.61215029
93regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.60531208
94regulation of memory T cell differentiation (GO:0043380)2.60253656
95negative thymic T cell selection (GO:0045060)2.59111217
96lymphocyte activation involved in immune response (GO:0002285)2.58910782
97regulation of chemokine biosynthetic process (GO:0045073)2.57483661
98T-helper 1 type immune response (GO:0042088)2.56130731
99regulation of T cell mediated cytotoxicity (GO:0001914)2.55533988
100positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55160918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06962172
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.53954585
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50152332
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35937208
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25343926
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85788943
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.83823374
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70801585
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65595475
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.65049665
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64721288
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.60459914
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.25445224
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21151631
15VDR_22108803_ChIP-Seq_LS180_Human2.17300904
16MYB_26560356_Chip-Seq_TH2_Human2.08548370
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.04371614
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00428028
19RUNX_20019798_ChIP-Seq_JUKART_Human1.97272477
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93915248
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91593973
22ELK1_19687146_ChIP-ChIP_HELA_Human1.90291705
23TAF15_26573619_Chip-Seq_HEK293_Human1.87917948
24EWS_26573619_Chip-Seq_HEK293_Human1.87060154
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85664322
26VDR_23849224_ChIP-Seq_CD4+_Human1.82264447
27IRF1_19129219_ChIP-ChIP_H3396_Human1.80750519
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78180842
29GATA3_26560356_Chip-Seq_TH2_Human1.76272883
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66390986
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54469320
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52614226
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51524498
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50927357
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50725101
36STAT1_20625510_ChIP-Seq_HELA_Human1.48236660
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47968226
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.39281045
39FUS_26573619_Chip-Seq_HEK293_Human1.39039803
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38893631
41GATA3_26560356_Chip-Seq_TH1_Human1.35966350
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35686314
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.35686314
44NANOG_19829295_ChIP-Seq_ESCs_Human1.32436890
45SOX2_19829295_ChIP-Seq_ESCs_Human1.32436890
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.32129419
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31760241
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31241161
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30560821
50TP53_22573176_ChIP-Seq_HFKS_Human1.29729673
51ER_23166858_ChIP-Seq_MCF-7_Human1.28309633
52P300_19829295_ChIP-Seq_ESCs_Human1.27346746
53GATA3_27048872_Chip-Seq_THYMUS_Human1.25234461
54SPI1_23547873_ChIP-Seq_NB4_Human1.25232286
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24514181
56SMRT_27268052_Chip-Seq_Bcells_Human1.24248734
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21083525
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.20397681
59ZNF274_21170338_ChIP-Seq_K562_Hela1.20089260
60FOXP3_21729870_ChIP-Seq_TREG_Human1.19711259
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19232281
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18391462
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.16411164
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16359231
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15833147
66MYC_18940864_ChIP-ChIP_HL60_Human1.15473773
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14670772
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13627187
69SALL4_22934838_ChIP-ChIP_CD34+_Human1.11843338
70BCAT_22108803_ChIP-Seq_LS180_Human1.10350788
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09831462
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08366658
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08033521
74TAF2_19829295_ChIP-Seq_ESCs_Human1.05946281
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05871763
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.04605263
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.03720812
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.02167719
79NCOR_22424771_ChIP-Seq_293T_Human1.00770077
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99909034
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99455645
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98581094
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98389345
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98098475
85MYB_26560356_Chip-Seq_TH1_Human0.96986128
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.95049463
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94457410
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94358283
89CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93797217
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.92933002
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92920276
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.92664559
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91578579
94STAT3_23295773_ChIP-Seq_U87_Human0.91414977
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91153876
96NFYA_21822215_ChIP-Seq_K562_Human0.89036986
97AR_20517297_ChIP-Seq_VCAP_Human0.86694357
98PHF8_20622853_ChIP-Seq_HELA_Human0.86396941
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84920921
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84806841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.94473896
2MP0001835_abnormal_antigen_presentation4.79701394
3MP0001873_stomach_inflammation4.27483218
4MP0005671_abnormal_response_to4.00412591
5MP0008875_abnormal_xenobiotic_pharmacok3.82814205
6MP0005451_abnormal_body_composition3.72971350
7MP0008872_abnormal_physiological_respon3.07473845
8MP0002166_altered_tumor_susceptibility2.82911255
9MP0005387_immune_system_phenotype2.82255025
10MP0001790_abnormal_immune_system2.82255025
11MP0001800_abnormal_humoral_immune2.79950782
12MP0004381_abnormal_hair_follicle2.69330168
13MP0000685_abnormal_immune_system2.49911645
14MP0005000_abnormal_immune_tolerance2.45576874
15MP0005310_abnormal_salivary_gland2.40900012
16MP0002148_abnormal_hypersensitivity_rea2.32096078
17MP0002006_tumorigenesis2.28232332
18MP0009785_altered_susceptibility_to2.14690956
19MP0003195_calcinosis2.07707594
20MP0002723_abnormal_immune_serum2.05056284
21MP0006072_abnormal_retinal_apoptosis1.96007313
22MP0005645_abnormal_hypothalamus_physiol1.93298043
23MP0002452_abnormal_antigen_presenting1.90090233
24MP0002163_abnormal_gland_morphology1.79612834
25MP0002420_abnormal_adaptive_immunity1.78551348
26MP0001819_abnormal_immune_cell1.75460588
27MP0003724_increased_susceptibility_to1.59930237
28MP0002139_abnormal_hepatobiliary_system1.59630114
29MP0005025_abnormal_response_to1.56576450
30MP0002398_abnormal_bone_marrow1.48890633
31MP0000427_abnormal_hair_cycle1.41551146
32MP0006082_CNS_inflammation1.36165718
33MP0010155_abnormal_intestine_physiology1.35422463
34MP0000716_abnormal_immune_system1.33009907
35MP0003763_abnormal_thymus_physiology1.30063984
36MP0008877_abnormal_DNA_methylation1.29947663
37MP0001845_abnormal_inflammatory_respons1.26901229
38MP0003866_abnormal_defecation1.25714544
39MP0009333_abnormal_splenocyte_physiolog1.22567818
40MP0002405_respiratory_system_inflammati1.21609873
41MP0000689_abnormal_spleen_morphology1.20028903
42MP0005075_abnormal_melanosome_morpholog1.19089923
43MP0003436_decreased_susceptibility_to1.18268348
44MP0008057_abnormal_DNA_replication1.15580452
45MP0005085_abnormal_gallbladder_physiolo1.14502259
46MP0003806_abnormal_nucleotide_metabolis1.13747268
47MP0001663_abnormal_digestive_system1.12317147
48MP0002429_abnormal_blood_cell1.12257036
49MP0002419_abnormal_innate_immunity1.10707931
50MP0000465_gastrointestinal_hemorrhage1.09921071
51MP0005379_endocrine/exocrine_gland_phen1.07984680
52MP0003303_peritoneal_inflammation1.01039144
53MP0002693_abnormal_pancreas_physiology1.00193922
54MP0002722_abnormal_immune_system0.99732185
55MP0005084_abnormal_gallbladder_morpholo0.99573769
56MP0005646_abnormal_pituitary_gland0.97411985
57MP0002160_abnormal_reproductive_system0.96907376
58MP0004782_abnormal_surfactant_physiolog0.96251083
59MP0009764_decreased_sensitivity_to0.96122494
60MP0003786_premature_aging0.96095501
61MP0003252_abnormal_bile_duct0.94469001
62MP0002396_abnormal_hematopoietic_system0.94181384
63MP0002933_joint_inflammation0.91608943
64MP0001661_extended_life_span0.90870722
65MP0000383_abnormal_hair_follicle0.86310668
66MP0004043_abnormal_pH_regulation0.85982226
67MP0002138_abnormal_hepatobiliary_system0.84795877
68MP0005389_reproductive_system_phenotype0.84351262
69MP0008469_abnormal_protein_level0.83719192
70MP0001765_abnormal_ion_homeostasis0.81567095
71MP0002928_abnormal_bile_duct0.80845241
72MP0010678_abnormal_skin_adnexa0.79067760
73MP0000703_abnormal_thymus_morphology0.78220951
74MP0002019_abnormal_tumor_incidence0.76462544
75MP0001666_abnormal_nutrient_absorption0.76168944
76MP0005464_abnormal_platelet_physiology0.75458027
77MP0010307_abnormal_tumor_latency0.72341087
78MP0000013_abnormal_adipose_tissue0.70848427
79MP0002876_abnormal_thyroid_physiology0.68119487
80MP0002638_abnormal_pupillary_reflex0.67734682
81MP0010094_abnormal_chromosome_stability0.67222258
82MP0005367_renal/urinary_system_phenotyp0.66279445
83MP0000516_abnormal_urinary_system0.66279445
84MP0006036_abnormal_mitochondrial_physio0.66211128
85MP0008058_abnormal_DNA_repair0.65236491
86MP0001881_abnormal_mammary_gland0.64253933
87MP0009765_abnormal_xenobiotic_induced0.63927348
88MP0001905_abnormal_dopamine_level0.63543396
89MP0004742_abnormal_vestibular_system0.63341133
90MP0006035_abnormal_mitochondrial_morpho0.62001594
91MP0005220_abnormal_exocrine_pancreas0.60838707
92MP0005166_decreased_susceptibility_to0.58341233
93MP0002277_abnormal_respiratory_mucosa0.56291100
94MP0005253_abnormal_eye_physiology0.55755670
95MP0005381_digestive/alimentary_phenotyp0.55698961
96MP0003011_delayed_dark_adaptation0.55640135
97MP0004947_skin_inflammation0.54104629
98MP0001968_abnormal_touch/_nociception0.52994932
99MP0000372_irregular_coat_pigmentation0.51685874
100MP0004885_abnormal_endolymph0.50153300

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)3.74331682
2Meckel diverticulum (HP:0002245)3.66883638
3Abnormality of the ileum (HP:0001549)3.45205298
4Aplastic anemia (HP:0001915)3.22556232
5Hypoproteinemia (HP:0003075)3.19466835
6Stomatitis (HP:0010280)3.15592255
7Intestinal atresia (HP:0011100)3.07346810
8Recurrent fungal infections (HP:0002841)3.03350865
9B lymphocytopenia (HP:0010976)3.02480132
10Abnormality of the pulmonary veins (HP:0011718)3.01157907
11Colon cancer (HP:0003003)2.97686172
12Aplasia/hypoplasia of the uterus (HP:0008684)2.93369136
13Hypoplasia of the uterus (HP:0000013)2.87925780
14T lymphocytopenia (HP:0005403)2.84162678
15Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82807426
16Constricted visual fields (HP:0001133)2.79827153
17Recurrent viral infections (HP:0004429)2.70081773
18Abnormality of the prostate (HP:0008775)2.67645451
19Abnormality of B cell number (HP:0010975)2.63592802
20Abnormality of T cell number (HP:0011839)2.63021639
21Eosinophilia (HP:0001880)2.62296454
22Optic neuritis (HP:0100653)2.60168229
23Retrobulbar optic neuritis (HP:0100654)2.60168229
24Abnormality of T cells (HP:0002843)2.59545154
25Severe combined immunodeficiency (HP:0004430)2.58816978
26Recurrent bronchitis (HP:0002837)2.54262964
27Gastrointestinal stroma tumor (HP:0100723)2.53726007
28Recurrent sinusitis (HP:0011108)2.53672334
29Pancreatic cysts (HP:0001737)2.53614382
30Vasculitis (HP:0002633)2.50603983
31IgA deficiency (HP:0002720)2.47611967
32Severe short stature (HP:0003510)2.46298523
33Thyroiditis (HP:0100646)2.43324992
34Abnormal rod and cone electroretinograms (HP:0008323)2.42830862
35Congenital stationary night blindness (HP:0007642)2.40950869
36Abnormality of eosinophils (HP:0001879)2.38933413
37Asplenia (HP:0001746)2.36963517
38Hemoptysis (HP:0002105)2.36198386
39Panhypogammaglobulinemia (HP:0003139)2.32536842
40Granulocytopenia (HP:0001913)2.30506048
41Abnormality of the preputium (HP:0100587)2.30423633
42Pulmonary infiltrates (HP:0002113)2.28216621
43Growth hormone deficiency (HP:0000824)2.26616419
44Carpal bone hypoplasia (HP:0001498)2.26411873
45Alveolar cell carcinoma (HP:0006519)2.24175334
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.23949445
47Lymphopenia (HP:0001888)2.23762235
48Abnormality of T cell physiology (HP:0011840)2.22221260
49Annular pancreas (HP:0001734)2.20524452
50Chronic diarrhea (HP:0002028)2.20295359
51Chronic hepatic failure (HP:0100626)2.15958731
52Abnormality of the fetal cardiovascular system (HP:0010948)2.13361918
53Abnormal umbilical cord blood vessels (HP:0011403)2.13361918
54Single umbilical artery (HP:0001195)2.13361918
55Myositis (HP:0100614)2.12032576
56Gastrointestinal infarctions (HP:0005244)2.10377489
57Pustule (HP:0200039)2.09454484
58Agammaglobulinemia (HP:0004432)2.05453348
59Meningitis (HP:0001287)2.05022068
60Albinism (HP:0001022)2.04592314
61Chest pain (HP:0100749)2.04453954
62Progressive macrocephaly (HP:0004481)2.04201792
63Increased CSF lactate (HP:0002490)2.04017227
64Gangrene (HP:0100758)2.02947155
65True hermaphroditism (HP:0010459)2.02630179
66Dyschromatopsia (HP:0007641)2.01376926
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.00429566
68Pancreatic fibrosis (HP:0100732)1.99479386
69Leukocytosis (HP:0001974)1.99167918
70Orchitis (HP:0100796)1.97996203
71Selective tooth agenesis (HP:0001592)1.96788422
72Amaurosis fugax (HP:0100576)1.95633181
73Neoplasm of the tracheobronchial system (HP:0100552)1.95369559
74Abnormality of cells of the lymphoid lineage (HP:0012140)1.94734309
75Combined immunodeficiency (HP:0005387)1.93437471
76Short tibia (HP:0005736)1.93430108
77Mitochondrial inheritance (HP:0001427)1.93228197
78Duodenal stenosis (HP:0100867)1.92865553
79Small intestinal stenosis (HP:0012848)1.92865553
80Chronic mucocutaneous candidiasis (HP:0002728)1.92459696
81Recurrent cutaneous fungal infections (HP:0011370)1.92459696
82Prostate neoplasm (HP:0100787)1.92148322
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.91986926
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.91979476
85Oral leukoplakia (HP:0002745)1.90826218
86Increased serum lactate (HP:0002151)1.89666659
87Acute necrotizing encephalopathy (HP:0006965)1.89016289
88Pulmonary fibrosis (HP:0002206)1.86387921
89Arterial thrombosis (HP:0004420)1.85998432
90Clubbing of toes (HP:0100760)1.85738990
91Hepatocellular necrosis (HP:0001404)1.84544865
92Bronchiectasis (HP:0002110)1.82630650
93Lymphoma (HP:0002665)1.82505711
94Paralysis (HP:0003470)1.80569093
95Impaired platelet aggregation (HP:0003540)1.78566209
96Abnormal platelet function (HP:0011869)1.78566209
97Congenital, generalized hypertrichosis (HP:0004540)1.76715962
98Hyperlipoproteinemia (HP:0010980)1.76319195
99Bronchitis (HP:0012387)1.75885564
100Abnormal pupillary function (HP:0007686)1.75305028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.89045293
2MAP3K124.43049190
3EIF2AK33.57163131
4NUAK13.56065415
5TXK3.38685939
6TAOK33.34297833
7OXSR13.32762886
8MAP4K12.64832005
9STK392.51886730
10BMPR22.36977491
11CDK192.32102140
12NME12.12967420
13FRK2.05132328
14VRK22.01251480
15EIF2AK11.82582853
16MAP3K141.79805670
17TLK11.63413560
18JAK31.60322770
19PAK31.56203629
20ZAK1.56156868
21RIPK41.53079210
22TAF11.42001108
23PBK1.35016059
24IKBKB1.34653449
25SRPK11.27637250
26BLK1.27300724
27JAK11.25916700
28PLK21.25261155
29TSSK61.21962600
30EIF2AK21.15579742
31MYLK1.14302896
32CSF1R1.13649304
33MUSK1.08288816
34DAPK11.05430771
35SYK1.05110583
36IKBKE1.05072698
37PRKCI0.98866586
38KIT0.96027027
39GRK10.92205087
40ADRBK20.90155609
41FES0.90069391
42PIK3CG0.87766867
43ITK0.82535316
44GRK50.82418818
45TNIK0.82008208
46MAP3K110.78946743
47PRKCQ0.75299136
48BRD40.75167841
49STK100.74067900
50MKNK20.70575297
51LYN0.69428044
52INSRR0.66688588
53LCK0.66087390
54PLK30.61906658
55BTK0.61209012
56TRPM70.61105555
57TYK20.60962903
58TRIM280.60718252
59FER0.60166544
60STK38L0.59958138
61ACVR1B0.59560270
62IRAK10.58625481
63BUB10.58270869
64MAP3K10.57659685
65HIPK20.57267946
66EPHA30.55669767
67DYRK20.55611990
68CHUK0.55536161
69IRAK40.53827810
70JAK20.53093592
71TEC0.52934767
72FGFR30.52799114
73MAPKAPK50.51498766
74ALK0.50696097
75TBK10.50136993
76STK40.46451579
77MAP4K20.44827424
78MKNK10.44670495
79CSNK1G20.44490650
80STK30.44134584
81FLT30.44104055
82VRK10.43985460
83CCNB10.41911777
84MAP3K50.41574783
85BCKDK0.39778673
86HCK0.37332096
87PINK10.37120480
88NLK0.36839773
89PIM10.36541844
90BMPR1B0.35559189
91SIK30.35288641
92STK110.31422415
93KDR0.31323756
94PRKCE0.30177274
95ABL10.30044389
96CSNK1G30.29456437
97ERBB30.29337660
98MAPKAPK30.28212386
99MELK0.27768575
100CSNK1A1L0.27462193

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.07581359
2Asthma_Homo sapiens_hsa053104.98887844
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.93902933
4Autoimmune thyroid disease_Homo sapiens_hsa053204.56104918
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.70418110
6Graft-versus-host disease_Homo sapiens_hsa053323.23006906
7Type I diabetes mellitus_Homo sapiens_hsa049403.00103104
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.78462759
9Proteasome_Homo sapiens_hsa030502.67539486
10Primary immunodeficiency_Homo sapiens_hsa053402.48539978
11Caffeine metabolism_Homo sapiens_hsa002322.48411059
12Leishmaniasis_Homo sapiens_hsa051402.11720195
13Antigen processing and presentation_Homo sapiens_hsa046122.04669820
14Hematopoietic cell lineage_Homo sapiens_hsa046401.80974709
15Protein export_Homo sapiens_hsa030601.66705252
16Nitrogen metabolism_Homo sapiens_hsa009101.65570980
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62660723
18Rheumatoid arthritis_Homo sapiens_hsa053231.61007103
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.60975975
20T cell receptor signaling pathway_Homo sapiens_hsa046601.48987548
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46432584
22Viral myocarditis_Homo sapiens_hsa054161.41787014
23Measles_Homo sapiens_hsa051621.29766723
24Staphylococcus aureus infection_Homo sapiens_hsa051501.29160873
25One carbon pool by folate_Homo sapiens_hsa006701.25523435
26Homologous recombination_Homo sapiens_hsa034401.17160367
27RNA polymerase_Homo sapiens_hsa030201.10223074
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05431628
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92534313
30Oxidative phosphorylation_Homo sapiens_hsa001900.88900968
31B cell receptor signaling pathway_Homo sapiens_hsa046620.87902450
32Herpes simplex infection_Homo sapiens_hsa051680.86075758
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82528700
34Fanconi anemia pathway_Homo sapiens_hsa034600.81188841
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80756535
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.79660250
37Tuberculosis_Homo sapiens_hsa051520.75823339
38Tryptophan metabolism_Homo sapiens_hsa003800.74471544
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72389239
40Toxoplasmosis_Homo sapiens_hsa051450.72183802
41Influenza A_Homo sapiens_hsa051640.71676595
42Epstein-Barr virus infection_Homo sapiens_hsa051690.68731647
43beta-Alanine metabolism_Homo sapiens_hsa004100.66670667
44Selenocompound metabolism_Homo sapiens_hsa004500.65170653
45RNA degradation_Homo sapiens_hsa030180.64845750
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64690403
47Phototransduction_Homo sapiens_hsa047440.63720426
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62777363
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62088228
50Propanoate metabolism_Homo sapiens_hsa006400.61797967
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57351778
52Collecting duct acid secretion_Homo sapiens_hsa049660.54417266
53Linoleic acid metabolism_Homo sapiens_hsa005910.54383220
54Systemic lupus erythematosus_Homo sapiens_hsa053220.54010704
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.52735920
56Peroxisome_Homo sapiens_hsa041460.50148762
57Parkinsons disease_Homo sapiens_hsa050120.47224911
58Basal transcription factors_Homo sapiens_hsa030220.43022231
59Salivary secretion_Homo sapiens_hsa049700.41448752
60Regulation of autophagy_Homo sapiens_hsa041400.40807753
61African trypanosomiasis_Homo sapiens_hsa051430.38998858
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38483210
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37600369
64Phagosome_Homo sapiens_hsa041450.32071156
65Chemical carcinogenesis_Homo sapiens_hsa052040.31049124
66Osteoclast differentiation_Homo sapiens_hsa043800.30172513
67p53 signaling pathway_Homo sapiens_hsa041150.28023725
68Non-homologous end-joining_Homo sapiens_hsa034500.27976450
69Mismatch repair_Homo sapiens_hsa034300.27442370
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27236801
71RNA transport_Homo sapiens_hsa030130.26854805
72Dorso-ventral axis formation_Homo sapiens_hsa043200.26093043
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25761766
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.25706242
75Platelet activation_Homo sapiens_hsa046110.25047417
76ABC transporters_Homo sapiens_hsa020100.24280824
77Butanoate metabolism_Homo sapiens_hsa006500.23658582
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23216312
79Chemokine signaling pathway_Homo sapiens_hsa040620.23049073
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22906918
81Vitamin B6 metabolism_Homo sapiens_hsa007500.22152838
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21775873
83Taste transduction_Homo sapiens_hsa047420.20899855
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20291471
85N-Glycan biosynthesis_Homo sapiens_hsa005100.19605911
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18517554
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18246001
88Shigellosis_Homo sapiens_hsa051310.17923045
89Nucleotide excision repair_Homo sapiens_hsa034200.16941899
90Hepatitis B_Homo sapiens_hsa051610.15479333
91Pyrimidine metabolism_Homo sapiens_hsa002400.15439413
92Purine metabolism_Homo sapiens_hsa002300.14646208
93Legionellosis_Homo sapiens_hsa051340.14425614
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14209726
95Apoptosis_Homo sapiens_hsa042100.13691149
96TNF signaling pathway_Homo sapiens_hsa046680.13344104
97Alzheimers disease_Homo sapiens_hsa050100.12931090
98Retinol metabolism_Homo sapiens_hsa008300.12006021
99HTLV-I infection_Homo sapiens_hsa051660.10149491
100Sulfur metabolism_Homo sapiens_hsa009200.10013134

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