MYL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.53886925
2* cardiac myofibril assembly (GO:0055003)8.53491909
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.45074707
4negative regulation of potassium ion transmembrane transport (GO:1901380)7.68750116
5* myofibril assembly (GO:0030239)7.57288422
6cardiac muscle cell development (GO:0055013)6.88340394
7regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.87585152
8* muscle filament sliding (GO:0030049)6.74635096
9* actin-myosin filament sliding (GO:0033275)6.74635096
10* cardiac muscle contraction (GO:0060048)6.74015639
11skeletal muscle adaptation (GO:0043501)6.71123015
12tricarboxylic acid cycle (GO:0006099)6.54578843
13adult heart development (GO:0007512)6.47694746
14cardiac cell development (GO:0055006)6.46708698
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.46294917
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.44548143
17regulation of actin filament-based movement (GO:1903115)6.31233057
18striated muscle atrophy (GO:0014891)6.24778622
19regulation of relaxation of muscle (GO:1901077)6.12927876
20skeletal muscle contraction (GO:0003009)6.07770899
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.05866571
22* cardiac muscle tissue morphogenesis (GO:0055008)6.04552156
23* ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.01611663
24ventricular cardiac muscle cell action potential (GO:0086005)6.01498657
25plasma membrane repair (GO:0001778)6.00270299
26cardiac muscle hypertrophy (GO:0003300)5.93593149
27regulation of sarcomere organization (GO:0060297)5.92721119
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.76269060
29bundle of His cell to Purkinje myocyte communication (GO:0086069)5.75602798
30* actomyosin structure organization (GO:0031032)5.75321928
31heart trabecula formation (GO:0060347)5.70221666
32muscle atrophy (GO:0014889)5.67908286
33striated muscle hypertrophy (GO:0014897)5.60947383
34* actin-mediated cell contraction (GO:0070252)5.56132925
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.51207775
36* muscle tissue morphogenesis (GO:0060415)5.35947644
37regulation of the force of heart contraction (GO:0002026)5.34401672
38regulation of skeletal muscle contraction (GO:0014819)5.27180226
39* striated muscle contraction (GO:0006941)5.15605709
40regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.14507712
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.06993366
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98873069
43muscle hypertrophy (GO:0014896)4.97488611
44carnitine shuttle (GO:0006853)4.94078081
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.88608094
46regulation of cell communication by electrical coupling (GO:0010649)4.88043578
47* regulation of striated muscle contraction (GO:0006942)4.85916242
48regulation of membrane repolarization (GO:0060306)4.85093932
49cell communication involved in cardiac conduction (GO:0086065)4.83450513
50detection of calcium ion (GO:0005513)4.76589163
51ATP synthesis coupled proton transport (GO:0015986)4.70652089
52energy coupled proton transport, down electrochemical gradient (GO:0015985)4.70652089
53response to inactivity (GO:0014854)4.68910990
54regulation of acyl-CoA biosynthetic process (GO:0050812)4.68241986
55negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.64533149
56* muscle system process (GO:0003012)4.58774517
57sarcoplasmic reticulum calcium ion transport (GO:0070296)4.55253711
58cellular response to epinephrine stimulus (GO:0071872)4.41838918
59regulation of cardiac muscle contraction (GO:0055117)4.38486049
60cardiac muscle hypertrophy in response to stress (GO:0014898)4.37155823
61muscle hypertrophy in response to stress (GO:0003299)4.37155823
62cardiac muscle adaptation (GO:0014887)4.37155823
63cell communication by electrical coupling (GO:0010644)4.36960670
64response to muscle activity (GO:0014850)4.33218884
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32952104
66negative regulation of striated muscle cell apoptotic process (GO:0010664)4.32112512
67regulation of cardiac muscle cell contraction (GO:0086004)4.29971208
68regulation of coenzyme metabolic process (GO:0051196)4.29540834
69regulation of cofactor metabolic process (GO:0051193)4.29540834
70positive regulation of ATPase activity (GO:0032781)4.29465688
71positive regulation of ATP catabolic process (GO:1903291)4.29465688
72response to epinephrine (GO:0071871)4.28534843
73regulation of heart rate (GO:0002027)4.26993687
74negative regulation of protein localization to cell surface (GO:2000009)4.26543336
75respiratory electron transport chain (GO:0022904)4.26227605
76regulation of cardioblast differentiation (GO:0051890)4.25968815
77fatty acid transmembrane transport (GO:1902001)4.24676873
78ventricular cardiac muscle cell development (GO:0055015)4.23007560
79cardiac muscle cell action potential involved in contraction (GO:0086002)4.19685525
80negative regulation of potassium ion transport (GO:0043267)4.18993502
81* actin filament-based movement (GO:0030048)4.15420733
82electron transport chain (GO:0022900)4.13576653
83cardiac muscle cell action potential (GO:0086001)4.13311308
84regulation of ATP catabolic process (GO:1903289)4.11728033
85regulation of ATPase activity (GO:0043462)4.11728033
86relaxation of cardiac muscle (GO:0055119)4.05107045
87oxidative phosphorylation (GO:0006119)3.98653069
88response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.96251587
89positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.94905969
90regulation of heart contraction (GO:0008016)3.94244021
91response to caffeine (GO:0031000)3.85825559
92NADH metabolic process (GO:0006734)3.83298030
93positive regulation of potassium ion transmembrane transport (GO:1901381)3.76829494
94muscle adaptation (GO:0043500)3.76486722
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.76178844
962-oxoglutarate metabolic process (GO:0006103)3.75422036
97* heart contraction (GO:0060047)3.73359485
98* heart process (GO:0003015)3.73359485
99cardiac conduction (GO:0061337)3.66892259
100trabecula formation (GO:0060343)3.66724258
101* regulation of muscle contraction (GO:0006937)3.65912167
102calcium-mediated signaling using intracellular calcium source (GO:0035584)3.64505593
103carnitine transmembrane transport (GO:1902603)3.62534779
104positive regulation of ion transmembrane transporter activity (GO:0032414)3.57859081
105regulation of heart rate by cardiac conduction (GO:0086091)3.55669035
106oxygen transport (GO:0015671)3.53816746
107positive regulation of heart contraction (GO:0045823)3.50261741
108positive regulation of heart rate (GO:0010460)3.50049894
109creatine metabolic process (GO:0006600)3.49687361
110* striated muscle cell development (GO:0055002)3.47999295
111regulation of sulfur metabolic process (GO:0042762)3.47906086
112* regulation of muscle system process (GO:0090257)3.45929020
113positive regulation of cation channel activity (GO:2001259)3.45097050
114regulation of striated muscle cell apoptotic process (GO:0010662)3.43461830
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43314992
116negative regulation of calcium ion transmembrane transport (GO:1903170)3.42974958
117negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.42974958
118negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38453500
119regulation of calcium ion transmembrane transport (GO:1903169)3.36473515
120regulation of calcium ion transmembrane transporter activity (GO:1901019)3.36473515
121regulation of sequestering of triglyceride (GO:0010889)3.35355154
122regulation of potassium ion transmembrane transporter activity (GO:1901016)3.35225931
123striated muscle adaptation (GO:0014888)3.32173858
124potassium ion export (GO:0071435)3.30686702
125* muscle contraction (GO:0006936)3.29806068
126response to redox state (GO:0051775)3.26989500
127positive regulation of potassium ion transport (GO:0043268)3.20918426
128negative regulation of ion transmembrane transporter activity (GO:0032413)3.09319673
129adrenergic receptor signaling pathway (GO:0071875)3.03696486
130skeletal muscle tissue development (GO:0007519)3.02669042
131positive regulation of transporter activity (GO:0032411)3.02539652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.95112942
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.52828362
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.85466142
4* TBX20_22080862_ChIP-Seq_HEART_Mouse4.38412172
5* TBX20_22328084_ChIP-Seq_HEART_Mouse4.38412172
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.17077437
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.93331609
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.65233328
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.48773330
10ZNF263_19887448_ChIP-Seq_K562_Human3.23154338
11ESR1_20079471_ChIP-ChIP_T-47D_Human3.13028672
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.01359284
13GATA4_21415370_ChIP-Seq_HL-1_Mouse2.70028088
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68253076
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.38467295
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38295279
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04666102
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04439778
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99432046
20EZH2_22144423_ChIP-Seq_EOC_Human1.99016049
21NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.98088036
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.97713070
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.95143253
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91167445
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77557594
26CLOCK_20551151_ChIP-Seq_293T_Human1.73684456
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65711736
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63024752
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.62035665
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59382197
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51902926
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51601516
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49535306
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.49370016
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46179631
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45614929
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42664752
38CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36307811
39NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31938254
40IGF1R_20145208_ChIP-Seq_DFB_Human1.31082692
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30793936
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.29100849
43GATA1_19941826_ChIP-Seq_K562_Human1.25532985
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24199463
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23120693
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.22640477
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21217769
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20604426
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19043788
50KDM2B_26808549_Chip-Seq_DND41_Human1.18373640
51CTCF_27219007_Chip-Seq_Bcells_Human1.18351876
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17683582
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.17432810
54TP63_22573176_ChIP-Seq_HFKS_Human1.17278478
55GATA1_22025678_ChIP-Seq_K562_Human1.17044851
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13931506
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13547522
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11457687
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.10457167
60DROSHA_22980978_ChIP-Seq_HELA_Human1.08560095
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07418057
62* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05750661
63VDR_22108803_ChIP-Seq_LS180_Human1.05697400
64LXR_22292898_ChIP-Seq_THP-1_Human1.04322626
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.04152385
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03547160
67* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01595002
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.00681678
69SPI1_20517297_ChIP-Seq_HL60_Human1.00542824
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.00020760
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99445042
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98365867
73HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98178690
74RACK7_27058665_Chip-Seq_MCF-7_Human0.97612959
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97020424
76PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94641923
77* ATF3_27146783_Chip-Seq_COLON_Human0.94260634
78* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93935799
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93922228
80SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93869169
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93223880
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93135531
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93111242
84SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92693333
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92210723
86SOX2_21211035_ChIP-Seq_LN229_Gbm0.91886498
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91411963
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90530524
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.90462856
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89686449
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89207354
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.88206025
93* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88027060
94GATA2_19941826_ChIP-Seq_K562_Human0.87709645
95P68_20966046_ChIP-Seq_HELA_Human0.87633996
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.87091250
97RXR_22158963_ChIP-Seq_LIVER_Mouse0.86454407
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85821856
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.84990165
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.83912360
101SPI1_23127762_ChIP-Seq_K562_Human0.83886906
102GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83385041
103HNFA_21074721_ChIP-Seq_CACO-2_Human0.81701748
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81484566
105CBX2_22325352_ChIP-Seq_293T-Rex_Human0.80313346
106* HTT_18923047_ChIP-ChIP_STHdh_Human0.80310858
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79631784
108TP53_23651856_ChIP-Seq_MEFs_Mouse0.79134491
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78617928
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78547064
111MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78146662
112TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78026272
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77954633
114ZNF274_21170338_ChIP-Seq_K562_Hela0.77845242
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77439854
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.77197472
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77106517
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77059802
119GF1_26923725_Chip-Seq_HPCs_Mouse0.77010155
120PHF8_20622853_ChIP-Seq_HELA_Human0.76951517
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76690641
122FOXH1_21741376_ChIP-Seq_ESCs_Human0.76194827
123CJUN_26792858_Chip-Seq_BT549_Human0.76163262
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75378974
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74760775
126BCL6_27268052_Chip-Seq_Bcells_Human0.73775575
127* OCT4_20526341_ChIP-Seq_ESCs_Human0.73275955
128RBPJ_21746931_ChIP-Seq_IB4_Human0.72651147
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72443765
130BCOR_27268052_Chip-Seq_Bcells_Human0.72152250
131GATA6_21074721_ChIP-Seq_CACO-2_Human0.71959552
132* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70419228
133CTCF_21964334_Chip-Seq_Bcells_Human0.70381212
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69892797
135NFYB_21822215_ChIP-Seq_K562_Human0.69584196
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69319555
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.69136882
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68488172
139SMC4_20622854_ChIP-Seq_HELA_Human0.66862244
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.66794863
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.66280160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.39801966
2* MP0004084_abnormal_cardiac_muscle5.87503159
3MP0003646_muscle_fatigue5.53412389
4MP0000751_myopathy5.07777429
5* MP0004215_abnormal_myocardial_fiber4.81597968
6* MP0004036_abnormal_muscle_relaxation4.18353471
7* MP0005330_cardiomyopathy4.00374522
8MP0000749_muscle_degeneration3.82232033
9* MP0002972_abnormal_cardiac_muscle3.36916620
10MP0008775_abnormal_heart_ventricle3.26834649
11* MP0004087_abnormal_muscle_fiber3.07503398
12* MP0003137_abnormal_impulse_conducting2.88844011
13* MP0001544_abnormal_cardiovascular_syste2.79035929
14* MP0005385_cardiovascular_system_phenoty2.79035929
15* MP0010630_abnormal_cardiac_muscle2.75544693
16* MP0005620_abnormal_muscle_contractility2.70486282
17MP0000750_abnormal_muscle_regeneration2.68143218
18MP0004484_altered_response_of2.55359211
19MP0002106_abnormal_muscle_physiology2.44973938
20MP0004130_abnormal_muscle_cell2.40059679
21* MP0006138_congestive_heart_failure2.34823393
22MP0002269_muscular_atrophy2.23442827
23* MP0004085_abnormal_heartbeat2.22581687
24MP0003221_abnormal_cardiomyocyte_apopto2.09941115
25MP0004510_myositis1.97027776
26MP0005369_muscle_phenotype1.96774245
27MP0004145_abnormal_muscle_electrophysio1.91287424
28MP0000759_abnormal_skeletal_muscle1.84029567
29* MP0003828_pulmonary_edema1.82003782
30MP0003950_abnormal_plasma_membrane1.81932152
31MP0000747_muscle_weakness1.78275819
32MP0004233_abnormal_muscle_weight1.72963801
33MP0006036_abnormal_mitochondrial_physio1.71416201
34MP0003567_abnormal_fetal_cardiomyocyte1.53501388
35* MP0002127_abnormal_cardiovascular_syste1.44738622
36MP0002332_abnormal_exercise_endurance1.34928212
37MP0005666_abnormal_adipose_tissue1.32165016
38MP0010368_abnormal_lymphatic_system1.28022839
39MP0003279_aneurysm1.27329156
40MP0008004_abnormal_stomach_pH1.27214269
41* MP0000266_abnormal_heart_morphology1.22695309
42MP0000343_altered_response_to1.20526188
43MP0005670_abnormal_white_adipose1.17644290
44MP0002234_abnormal_pharynx_morphology1.16595067
45MP0005165_increased_susceptibility_to1.15181004
46MP0006035_abnormal_mitochondrial_morpho1.03488977
47MP0002128_abnormal_blood_circulation0.89336259
48MP0005623_abnormal_meninges_morphology0.88970695
49MP0005375_adipose_tissue_phenotype0.86853172
50MP0003566_abnormal_cell_adhesion0.86311585
51MP0004185_abnormal_adipocyte_glucose0.85199156
52MP0000230_abnormal_systemic_arterial0.84256986
53MP0005451_abnormal_body_composition0.83441522
54MP0005266_abnormal_metabolism0.80490827
55MP0002108_abnormal_muscle_morphology0.72469403
56MP0003705_abnormal_hypodermis_morpholog0.71400650
57MP0004272_abnormal_basement_membrane0.71392555
58MP0000767_abnormal_smooth_muscle0.70965339
59MP0001879_abnormal_lymphatic_vessel0.70470052
60MP0001661_extended_life_span0.68128487
61MP0003806_abnormal_nucleotide_metabolis0.66790329
62MP0002909_abnormal_adrenal_gland0.60368219
63MP0005187_abnormal_penis_morphology0.53710921
64MP0004043_abnormal_pH_regulation0.52224972
65MP0008438_abnormal_cutaneous_collagen0.51879522
66* MP0002925_abnormal_cardiovascular_devel0.50460898
67MP0000733_abnormal_muscle_development0.49090432
68MP0005319_abnormal_enzyme/_coenzyme0.48618083
69MP0000003_abnormal_adipose_tissue0.48219722
70MP0009384_cardiac_valve_regurgitation0.47543277
71MP0004270_analgesia0.45286367
72* MP0003984_embryonic_growth_retardation0.45101785
73MP0004147_increased_porphyrin_level0.44327883
74* MP0002088_abnormal_embryonic_growth/wei0.44317448
75MP0000013_abnormal_adipose_tissue0.42497565
76MP0008569_lethality_at_weaning0.42476610
77MP0002078_abnormal_glucose_homeostasis0.41967116
78MP0002971_abnormal_brown_adipose0.39043817
79* MP0001614_abnormal_blood_vessel0.38977631
80MP0008260_abnormal_autophagy0.38963365
81* MP0001784_abnormal_fluid_regulation0.38171608
82MP0005275_abnormal_skin_tensile0.35736377
83MP0003045_fibrosis0.35587464
84MP0008961_abnormal_basal_metabolism0.34054790
85MP0001984_abnormal_olfaction0.33941219
86MP0003948_abnormal_gas_homeostasis0.32008908
87MP0005595_abnormal_vascular_smooth0.31154188
88MP0001727_abnormal_embryo_implantation0.30475553
89MP0005386_behavior/neurological_phenoty0.29048953
90MP0004924_abnormal_behavior0.29048953
91MP0001299_abnormal_eye_distance/0.28861713
92MP0005166_decreased_susceptibility_to0.28609403
93MP0005535_abnormal_body_temperature0.28078015
94MP0005377_hearing/vestibular/ear_phenot0.27401738
95MP0003878_abnormal_ear_physiology0.27401738
96MP0005167_abnormal_blood-brain_barrier0.27113199
97MP0002254_reproductive_system_inflammat0.26080187
98MP0002295_abnormal_pulmonary_circulatio0.25324084
99* MP0001672_abnormal_embryogenesis/_devel0.24388667
100* MP0005380_embryogenesis_phenotype0.24388667
101MP0009840_abnormal_foam_cell0.23461511
102MP0001958_emphysema0.22528847
103MP0002118_abnormal_lipid_homeostasis0.20134198
104MP0005584_abnormal_enzyme/coenzyme_acti0.19179687
105MP0005334_abnormal_fat_pad0.18207745
106MP0005452_abnormal_adipose_tissue0.17907707
107MP0008874_decreased_physiological_sensi0.17351666
108MP0000372_irregular_coat_pigmentation0.17009859
109MP0005083_abnormal_biliary_tract0.16744723
110MP0005376_homeostasis/metabolism_phenot0.16674112
111MP0009780_abnormal_chondrocyte_physiolo0.16495240
112MP0009115_abnormal_fat_cell0.15980513
113MP0005332_abnormal_amino_acid0.15965258
114MP0000762_abnormal_tongue_morphology0.15421383
115MP0010030_abnormal_orbit_morphology0.15322439
116MP0003879_abnormal_hair_cell0.15254219
117MP0002896_abnormal_bone_mineralization0.14141181
118MP0002066_abnormal_motor_capabilities/c0.12867230
119MP0003656_abnormal_erythrocyte_physiolo0.11243231
120MP0003195_calcinosis0.10284779
121MP0002638_abnormal_pupillary_reflex0.10116561

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.71738713
2Muscle fiber inclusion bodies (HP:0100299)7.81702403
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.73994741
4Nemaline bodies (HP:0003798)7.45764339
5* Ventricular tachycardia (HP:0004756)6.63512538
6Atrial fibrillation (HP:0005110)6.50132072
7Calf muscle hypertrophy (HP:0008981)6.29875765
8Primary atrial arrhythmia (HP:0001692)6.08533082
9Supraventricular tachycardia (HP:0004755)5.89009383
10Abnormality of the left ventricular outflow tract (HP:0011103)5.83953996
11Subaortic stenosis (HP:0001682)5.83953996
12Supraventricular arrhythmia (HP:0005115)5.77823354
13Lipoatrophy (HP:0100578)5.76934859
14Muscle hypertrophy of the lower extremities (HP:0008968)5.66341725
15Muscle fiber splitting (HP:0003555)5.54240826
16Exercise-induced muscle cramps (HP:0003710)5.52873853
17Abnormality of the calf musculature (HP:0001430)5.40559657
18Exercise-induced myalgia (HP:0003738)5.26016597
19Syncope (HP:0001279)5.11042598
20Right ventricular cardiomyopathy (HP:0011663)5.08656765
21Hyporeflexia of lower limbs (HP:0002600)4.87837989
22Dilated cardiomyopathy (HP:0001644)4.74667262
23Bundle branch block (HP:0011710)4.66664881
24Prolonged QT interval (HP:0001657)4.65410777
25Palpitations (HP:0001962)4.65069977
26Asymmetric septal hypertrophy (HP:0001670)4.54978380
27Ventricular arrhythmia (HP:0004308)4.40101842
28Myoglobinuria (HP:0002913)4.37953711
29EMG: myopathic abnormalities (HP:0003458)4.19480084
30Ventricular fibrillation (HP:0001663)3.98814616
31Heart block (HP:0012722)3.89933412
32Frequent falls (HP:0002359)3.86776292
33Myopathic facies (HP:0002058)3.83838572
34Atrioventricular block (HP:0001678)3.77381412
35Abnormal atrioventricular conduction (HP:0005150)3.67246128
36Distal arthrogryposis (HP:0005684)3.65859945
37Increased connective tissue (HP:0009025)3.54002761
38Round ear (HP:0100830)3.42738869
39Abnormal EKG (HP:0003115)3.35480296
40Rhabdomyolysis (HP:0003201)3.33223141
41Abnormal mitochondria in muscle tissue (HP:0008316)3.24641811
42Acute necrotizing encephalopathy (HP:0006965)3.23604134
43Myotonia (HP:0002486)3.19667877
44Left ventricular hypertrophy (HP:0001712)3.11510669
45Hepatic necrosis (HP:0002605)3.10364901
46Difficulty running (HP:0009046)2.99991765
47Ragged-red muscle fibers (HP:0003200)2.89659585
48Palmoplantar keratoderma (HP:0000982)2.85598314
49Acute encephalopathy (HP:0006846)2.77014944
50Ulnar deviation of the wrist (HP:0003049)2.76916740
51Hepatocellular necrosis (HP:0001404)2.72026290
52Ketoacidosis (HP:0001993)2.68845678
53Progressive macrocephaly (HP:0004481)2.67198435
54Hypoglycemic coma (HP:0001325)2.63350768
55Difficulty climbing stairs (HP:0003551)2.63049931
56Mitochondrial inheritance (HP:0001427)2.61757845
57Conjunctival hamartoma (HP:0100780)2.51883674
58Cerebral edema (HP:0002181)2.51439298
59Bulbar palsy (HP:0001283)2.50142250
60Distal lower limb muscle weakness (HP:0009053)2.50071697
61Increased CSF lactate (HP:0002490)2.46093364
62Calcaneovalgus deformity (HP:0001848)2.42179682
63Type 1 muscle fiber predominance (HP:0003803)2.41629208
64Neck muscle weakness (HP:0000467)2.38765006
65Dicarboxylic aciduria (HP:0003215)2.35108973
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35108973
67Progressive muscle weakness (HP:0003323)2.33924778
68Increased muscle lipid content (HP:0009058)2.32807484
69Abnormality of fatty-acid metabolism (HP:0004359)2.31943030
70Pheochromocytoma (HP:0002666)2.29004502
71Sudden cardiac death (HP:0001645)2.28610551
72Limb-girdle muscle atrophy (HP:0003797)2.26871060
73Areflexia of lower limbs (HP:0002522)2.24784225
74Absent phalangeal crease (HP:0006109)2.24197394
75Abnormality of the foot musculature (HP:0001436)2.22112831
76Abnormality of the shoulder girdle musculature (HP:0001435)2.21075246
77Exercise intolerance (HP:0003546)2.20235476
78Testicular atrophy (HP:0000029)2.18959221
79Increased variability in muscle fiber diameter (HP:0003557)2.17601553
80Muscle stiffness (HP:0003552)2.17423615
81Respiratory failure (HP:0002878)2.16854492
82Generalized aminoaciduria (HP:0002909)2.15282136
83Lactic acidosis (HP:0003128)2.13897300
84Congestive heart failure (HP:0001635)2.12471625
85Neoplasm of the adrenal gland (HP:0100631)2.11771044
86Deformed tarsal bones (HP:0008119)2.10962696
87Lower limb amyotrophy (HP:0007210)2.10231425
88Nausea (HP:0002018)2.09448980
89Increased intramyocellular lipid droplets (HP:0012240)2.07033925
90Respiratory insufficiency due to muscle weakness (HP:0002747)2.06407881
91Mildly elevated creatine phosphokinase (HP:0008180)2.05331928
92Congenital malformation of the right heart (HP:0011723)2.04801657
93Double outlet right ventricle (HP:0001719)2.04801657
94Neuroendocrine neoplasm (HP:0100634)2.04175664
95EMG: neuropathic changes (HP:0003445)2.03142678
96Hamartoma of the eye (HP:0010568)2.02229425
97Ketosis (HP:0001946)1.96141734
98Hip contracture (HP:0003273)1.95648578
99Abnormality of skeletal muscle fiber size (HP:0012084)1.95082406
100Spinal rigidity (HP:0003306)1.94234455
101Neoplasm of head and neck (HP:0012288)1.93851908
102Esophageal neoplasm (HP:0100751)1.93851908
103Foot dorsiflexor weakness (HP:0009027)1.93493034
104Proximal amyotrophy (HP:0007126)1.92167987
105Malignant hyperthermia (HP:0002047)1.91455042
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.91187229
107Dysmetric saccades (HP:0000641)1.91011967
108Weak cry (HP:0001612)1.88250020
109Large for gestational age (HP:0001520)1.86697472
110Generalized muscle weakness (HP:0003324)1.86482995
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85027744
112Abnormality of alanine metabolism (HP:0010916)1.85027744
113Hyperalaninemia (HP:0003348)1.85027744
114Lymphangioma (HP:0100764)1.84447339
115Abnormal finger flexion creases (HP:0006143)1.84133297
116Rimmed vacuoles (HP:0003805)1.82581316
117Waddling gait (HP:0002515)1.82030459
118Hypoplastic left heart (HP:0004383)1.82009200
119Distal lower limb amyotrophy (HP:0008944)1.81481026
120Hyperinsulinemic hypoglycemia (HP:0000825)1.81098525
121Renal cortical cysts (HP:0000803)1.80187729
122Pulmonary artery stenosis (HP:0004415)1.79158768
123Scapular winging (HP:0003691)1.78443303
124Muscular dystrophy (HP:0003560)1.77648375
125Hypoplastic ischia (HP:0003175)1.77543040
126Gowers sign (HP:0003391)1.75747435
127Steppage gait (HP:0003376)1.74238908
128Fatigable weakness (HP:0003473)1.66465422
129Abnormality of the neuromuscular junction (HP:0003398)1.66465422
130Proximal tubulopathy (HP:0000114)1.64949076
131Increased serum pyruvate (HP:0003542)1.64548921
132Shoulder girdle muscle weakness (HP:0003547)1.60043138
133Abnormality of the hip-girdle musculature (HP:0001445)1.59320359
134Abnormality of the musculature of the pelvis (HP:0001469)1.59320359
135Pelvic girdle muscle weakness (HP:0003749)1.57515020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.64417084
2MYLK4.43123311
3OBSCN4.29528567
4LMTK24.29285314
5PHKG23.73377962
6PHKG13.73377962
7PKN23.52393481
8PDK43.43762203
9PDK33.43762203
10DMPK3.22226284
11TRIB32.71936519
12NEK12.47188857
13PIK3CA2.41824027
14STK242.39100115
15TIE12.37275337
16BCKDK2.32329345
17MUSK2.24901043
18PDK22.03844367
19PIK3CG1.88265038
20PINK11.72060514
21PAK31.58532651
22PRKD11.42934394
23ILK1.42830756
24GRK71.40343682
25TAOK11.35303837
26CAMK2D1.32351254
27STK41.17596041
28WNK41.16161509
29EEF2K1.08012447
30FLT31.03199469
31STK38L1.02683318
32ZAK1.01401970
33MAPKAPK30.99810071
34MAP3K50.98914654
35MAPK120.96933655
36RIPK10.92640506
37MAP3K70.91938436
38TRPM70.91526540
39CCNB10.90562637
40PKN10.89891093
41MAPK40.85937562
42PRKAA10.84128696
43INSRR0.83916524
44MAP3K60.82025912
45ERBB30.81390388
46MARK10.81014127
47CAMK40.79480471
48PRKAA20.78465843
49PDGFRA0.76555255
50TBK10.72952115
51KDR0.72690460
52STK380.71972260
53* ROCK10.71758697
54ROCK20.69049223
55PTK2B0.67121171
56RPS6KC10.65817071
57RPS6KL10.65817071
58MAP3K30.64475166
59CAMK2A0.64089483
60WNK10.63171100
61MAP2K30.61781798
62KSR20.61654033
63LIMK10.61293379
64CAMK10.59980301
65TGFBR20.59229355
66CAMK2B0.57153989
67RPS6KA60.56092165
68STK390.55523399
69PRKACB0.53992146
70EPHA30.53509741
71PRKCE0.51181394
72ICK0.46075883
73SGK20.46038272
74EPHB10.45921971
75MAP2K10.45106362
76NME20.43784897
77PRKACG0.41819801
78DYRK1B0.41344165
79PRKACA0.40755085
80RAF10.39614616
81PRKD30.37257519
82PTK60.36623620
83PDPK10.36451476
84AKT20.34752330
85MAPK100.34214840
86MARK20.34093998
87MAP2K40.33337288
88ARAF0.33155528
89PDK10.31786360
90NEK90.31023790
91PRKCH0.29656352
92EPHB20.29097561
93PRKG20.28646534
94CAMK2G0.28517772
95SIK10.28381780
96PLK40.27588357
97RPS6KA10.27011014
98MAP3K100.27010831
99MOS0.26590053
100MAP2K60.24516044
101SGK4940.23337438
102SGK2230.23337438
103MTOR0.23080969
104PRKD20.22586268
105RET0.21096671
106LATS20.21033555
107LRRK20.20815397
108UHMK10.18106170
109PRKG10.18000682
110TAOK20.17752843
111FER0.17613406
112JAK10.14774522
113STK110.14329016
114SGK30.14306488
115RPS6KA20.14065662
116MAPKAPK20.13945458
117LATS10.13650620
118RPS6KA30.12930827
119TGFBR10.12623363
120MAPK90.12436346
121MAPK80.12345638
122NME10.11938336
123MAPK70.11892259
124MAPK110.11283036
125MAP3K110.10715870
126AKT10.10343430
127RPS6KB10.10340906
128PRKCQ0.10069813
129PDGFRB0.09716876
130FGFR30.09104959
131SGK10.08990637
132PAK60.08199280
133MARK30.05429970
134FGFR40.05421409
135ADRBK10.04711593

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.99858374
2* Cardiac muscle contraction_Homo sapiens_hsa042604.51195703
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.32358409
4* Dilated cardiomyopathy_Homo sapiens_hsa054143.77979534
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.64448756
6Parkinsons disease_Homo sapiens_hsa050123.54211485
7Oxidative phosphorylation_Homo sapiens_hsa001903.45971269
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28709379
9Propanoate metabolism_Homo sapiens_hsa006403.14488813
10Fatty acid degradation_Homo sapiens_hsa000712.80555225
11Alzheimers disease_Homo sapiens_hsa050102.57835765
12Carbon metabolism_Homo sapiens_hsa012002.46729577
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.39842352
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36157648
15Huntingtons disease_Homo sapiens_hsa050162.25175267
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20371321
17Fatty acid metabolism_Homo sapiens_hsa012122.09081885
18Viral myocarditis_Homo sapiens_hsa054161.92429056
19Pyruvate metabolism_Homo sapiens_hsa006201.79198262
20* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74424519
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54534423
22Butanoate metabolism_Homo sapiens_hsa006501.38275052
23Fatty acid elongation_Homo sapiens_hsa000621.26432207
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23422475
25Biosynthesis of amino acids_Homo sapiens_hsa012301.14376463
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10217493
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04260422
28PPAR signaling pathway_Homo sapiens_hsa033201.03978727
29Insulin resistance_Homo sapiens_hsa049310.97721786
30Glucagon signaling pathway_Homo sapiens_hsa049220.95504035
31Pentose phosphate pathway_Homo sapiens_hsa000300.91918262
32Starch and sucrose metabolism_Homo sapiens_hsa005000.90668856
33Adipocytokine signaling pathway_Homo sapiens_hsa049200.88094476
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83429227
35Tryptophan metabolism_Homo sapiens_hsa003800.80893161
36Lysine degradation_Homo sapiens_hsa003100.80443810
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79711499
38Insulin signaling pathway_Homo sapiens_hsa049100.77902353
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72295546
40Arginine biosynthesis_Homo sapiens_hsa002200.72103025
41HIF-1 signaling pathway_Homo sapiens_hsa040660.71547942
42Long-term potentiation_Homo sapiens_hsa047200.69034481
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68410832
44Calcium signaling pathway_Homo sapiens_hsa040200.68368518
45beta-Alanine metabolism_Homo sapiens_hsa004100.68269769
46* Focal adhesion_Homo sapiens_hsa045100.61747991
47Arginine and proline metabolism_Homo sapiens_hsa003300.59431279
48AMPK signaling pathway_Homo sapiens_hsa041520.58933680
49Type II diabetes mellitus_Homo sapiens_hsa049300.58648790
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54256849
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.54151174
52Amphetamine addiction_Homo sapiens_hsa050310.53625907
53Melanogenesis_Homo sapiens_hsa049160.53176610
54Galactose metabolism_Homo sapiens_hsa000520.51837858
55Oxytocin signaling pathway_Homo sapiens_hsa049210.51407368
56Phenylalanine metabolism_Homo sapiens_hsa003600.50583652
57ECM-receptor interaction_Homo sapiens_hsa045120.48354988
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.47846807
59Peroxisome_Homo sapiens_hsa041460.46016750
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44402105
61* Tight junction_Homo sapiens_hsa045300.43025135
62cAMP signaling pathway_Homo sapiens_hsa040240.41219021
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39460461
64Fatty acid biosynthesis_Homo sapiens_hsa000610.39246831
65MAPK signaling pathway_Homo sapiens_hsa040100.38253156
66Renin secretion_Homo sapiens_hsa049240.37758173
67Fructose and mannose metabolism_Homo sapiens_hsa000510.37333885
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35585014
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35437843
70Adherens junction_Homo sapiens_hsa045200.34951803
71Amoebiasis_Homo sapiens_hsa051460.33307106
72Insulin secretion_Homo sapiens_hsa049110.32284739
73Gastric acid secretion_Homo sapiens_hsa049710.31464886
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30925936
75Metabolic pathways_Homo sapiens_hsa011000.26310554
76Salivary secretion_Homo sapiens_hsa049700.25945242
77Regulation of autophagy_Homo sapiens_hsa041400.22187025
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.22031953
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.21753517
80Circadian entrainment_Homo sapiens_hsa047130.21606323
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21550670
82Morphine addiction_Homo sapiens_hsa050320.21509802
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20709892
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.20068025
85Cocaine addiction_Homo sapiens_hsa050300.19991088
86Sulfur relay system_Homo sapiens_hsa041220.18159540
87Histidine metabolism_Homo sapiens_hsa003400.17548944
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.15902616
89Proteoglycans in cancer_Homo sapiens_hsa052050.15493490
90Ovarian steroidogenesis_Homo sapiens_hsa049130.14609978
91Olfactory transduction_Homo sapiens_hsa047400.14557763
92Purine metabolism_Homo sapiens_hsa002300.14372975
93Platelet activation_Homo sapiens_hsa046110.13331385
94Renal cell carcinoma_Homo sapiens_hsa052110.13133674
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13041208
96Circadian rhythm_Homo sapiens_hsa047100.12647188
97Tyrosine metabolism_Homo sapiens_hsa003500.12432729
98Fat digestion and absorption_Homo sapiens_hsa049750.11449997
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11340716
100Gap junction_Homo sapiens_hsa045400.09902600
101* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08098631
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.07695556
103VEGF signaling pathway_Homo sapiens_hsa043700.07140356
104Bile secretion_Homo sapiens_hsa049760.06474411
105Dorso-ventral axis formation_Homo sapiens_hsa043200.06242722
106Pancreatic secretion_Homo sapiens_hsa049720.06081922
107Small cell lung cancer_Homo sapiens_hsa052220.05954957
108mTOR signaling pathway_Homo sapiens_hsa041500.05777340
109Glutathione metabolism_Homo sapiens_hsa004800.05747125
110GnRH signaling pathway_Homo sapiens_hsa049120.05729889
111GABAergic synapse_Homo sapiens_hsa047270.04872739
112Taste transduction_Homo sapiens_hsa047420.04647160
113Nitrogen metabolism_Homo sapiens_hsa009100.04580646
114Cholinergic synapse_Homo sapiens_hsa047250.03760310
115Toxoplasmosis_Homo sapiens_hsa051450.02481152
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.01999636
117* Leukocyte transendothelial migration_Homo sapiens_hsa046700.01597538
118Notch signaling pathway_Homo sapiens_hsa043300.01227785
119FoxO signaling pathway_Homo sapiens_hsa04068-0.0298221
120PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0179241
121Glycerolipid metabolism_Homo sapiens_hsa00561-0.0163887
122Estrogen signaling pathway_Homo sapiens_hsa04915-0.0062521

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