MYL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)4.96654744
2skeletal muscle contraction (GO:0003009)4.57202841
3positive regulation of protein kinase C signaling (GO:0090037)3.41832665
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.36517979
5positive regulation of defense response to virus by host (GO:0002230)3.24620183
6positive regulation of heat generation (GO:0031652)3.23845234
7NIK/NF-kappaB signaling (GO:0038061)3.19875860
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09587581
9muscle filament sliding (GO:0030049)3.08336340
10actin-myosin filament sliding (GO:0033275)3.08336340
11negative regulation of nitric oxide biosynthetic process (GO:0045019)3.08128504
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03109628
13negative regulation of cell killing (GO:0031342)3.03109628
14cellular response to ATP (GO:0071318)3.02714927
15cellular response to exogenous dsRNA (GO:0071360)3.02083612
16negative regulation of interleukin-12 production (GO:0032695)2.98923444
17immunoglobulin mediated immune response (GO:0016064)2.95092186
18mannose metabolic process (GO:0006013)2.91774651
19mature B cell differentiation involved in immune response (GO:0002313)2.90331191
20response to peptidoglycan (GO:0032494)2.87842571
21regulation of cytokine production involved in inflammatory response (GO:1900015)2.82558786
22negative regulation of tumor necrosis factor production (GO:0032720)2.79792400
23regulation of antigen processing and presentation (GO:0002577)2.77800789
24positive regulation of prostaglandin secretion (GO:0032308)2.73568613
25response to muramyl dipeptide (GO:0032495)2.73392538
26positive regulation of antigen processing and presentation (GO:0002579)2.72695583
27negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.70541717
28positive thymic T cell selection (GO:0045059)2.69079161
29germinal center formation (GO:0002467)2.67527494
30regulation of interferon-beta biosynthetic process (GO:0045357)2.67108689
31keratan sulfate catabolic process (GO:0042340)2.66519512
32regulation of chemokine biosynthetic process (GO:0045073)2.64991535
33tumor necrosis factor-mediated signaling pathway (GO:0033209)2.64758698
34negative regulation of granulocyte differentiation (GO:0030853)2.63515118
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60033210
36positive regulation of histone deacetylation (GO:0031065)2.59925373
37regulation of vitamin D biosynthetic process (GO:0060556)2.56398998
38regulation of T cell mediated cytotoxicity (GO:0001914)2.54873412
39response to interferon-beta (GO:0035456)2.54229893
40regulation of defense response to virus by host (GO:0050691)2.52030265
41GDP-mannose metabolic process (GO:0019673)2.47500393
42negative regulation of cytokine production involved in immune response (GO:0002719)2.45986772
43regulation of dendritic cell antigen processing and presentation (GO:0002604)2.45979904
44phosphatidylglycerol biosynthetic process (GO:0006655)2.45843064
45regulation of T-helper 1 cell differentiation (GO:0045625)2.45687449
46cellular response to interferon-beta (GO:0035458)2.44618715
47response to ATP (GO:0033198)2.44049081
48response to type I interferon (GO:0034340)2.43675312
49glycosphingolipid catabolic process (GO:0046479)2.42500268
50amino sugar catabolic process (GO:0046348)2.40842764
51T-helper cell differentiation (GO:0042093)2.40524721
52CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.40524721
53negative regulation of innate immune response (GO:0045824)2.39054649
54negative regulation of cell size (GO:0045792)2.38062240
55positive regulation of triglyceride lipase activity (GO:0061365)2.37888582
56positive regulation of lipoprotein lipase activity (GO:0051006)2.37888582
57RNA destabilization (GO:0050779)2.37208894
58regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.35996798
59cellular response to type I interferon (GO:0071357)2.35682269
60type I interferon signaling pathway (GO:0060337)2.35682269
61negative regulation of interleukin-8 production (GO:0032717)2.34528818
62positive regulation of chemokine biosynthetic process (GO:0045080)2.34201868
63regulation of interferon-alpha production (GO:0032647)2.33919980
64regulation of tumor necrosis factor production (GO:0032680)2.33016529
65tolerance induction (GO:0002507)2.32232656
66positive regulation of T cell mediated cytotoxicity (GO:0001916)2.32019608
67purine deoxyribonucleotide catabolic process (GO:0009155)2.31114898
68sphingolipid catabolic process (GO:0030149)2.30723729
69CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.29145349
70regulation of T-helper 1 type immune response (GO:0002825)2.27076709
71regulation of immunoglobulin secretion (GO:0051023)2.26217576
72positive regulation of T-helper 1 type immune response (GO:0002827)2.25726059
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.25345822
74myeloid dendritic cell differentiation (GO:0043011)2.25257584
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.24255942
76macrophage activation involved in immune response (GO:0002281)2.24163190
77positive regulation of myotube differentiation (GO:0010831)2.23289131
78actin-mediated cell contraction (GO:0070252)2.22848301
79membrane lipid catabolic process (GO:0046466)2.22710442
80regulation of chronic inflammatory response (GO:0002676)2.22512685
81Arp2/3 complex-mediated actin nucleation (GO:0034314)2.21407377
82regulation of interleukin-12 production (GO:0032655)2.21323281
83regulation of monocyte differentiation (GO:0045655)2.21079246
84regulation of memory T cell differentiation (GO:0043380)2.20096811
85interferon-gamma-mediated signaling pathway (GO:0060333)2.18947335
86positive regulation of protein deacetylation (GO:0090312)2.18574557
87glycolipid catabolic process (GO:0019377)2.18483284
88lysosome organization (GO:0007040)2.17631680
89lytic vacuole organization (GO:0080171)2.17631680
90lymphocyte chemotaxis (GO:0048247)2.17116860
91virion attachment to host cell (GO:0019062)2.17042673
92adhesion of symbiont to host cell (GO:0044650)2.17042673
93T-helper 1 type immune response (GO:0042088)2.16374631
94positive regulation of icosanoid secretion (GO:0032305)2.16327310
95oligosaccharide catabolic process (GO:0009313)2.15875339
96negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.14928162
97regulation of germinal center formation (GO:0002634)2.14913038
98negative regulation of T cell mediated immunity (GO:0002710)2.14418274
99ceramide catabolic process (GO:0046514)2.13828504
100negative regulation of myeloid cell apoptotic process (GO:0033033)2.13506409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.77704611
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.40119505
3VDR_21846776_ChIP-Seq_THP-1_Human2.75690053
4LXR_22292898_ChIP-Seq_THP-1_Human2.64225417
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43978810
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34063063
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33363304
8P68_20966046_ChIP-Seq_HELA_Human2.09235516
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.07672200
10BCL6_27268052_Chip-Seq_Bcells_Human2.07365729
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.04342894
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01323881
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99276327
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93617188
15VDR_24763502_ChIP-Seq_THP-1_Human1.90202702
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86077661
17CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85802830
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.84004986
19BCOR_27268052_Chip-Seq_Bcells_Human1.83481411
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78689743
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76799295
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76082977
23MAF_26560356_Chip-Seq_TH2_Human1.73776029
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71587892
25E2F1_20622854_ChIP-Seq_HELA_Human1.70843577
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.70580083
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69769281
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69636132
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68796808
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57950274
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57389437
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55402667
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54413715
34SA1_27219007_Chip-Seq_Bcells_Human1.53018572
35CTCF_26484167_Chip-Seq_Bcells_Mouse1.52837809
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.52218131
37PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52154342
38RACK7_27058665_Chip-Seq_MCF-7_Human1.52112802
39MAF_26560356_Chip-Seq_TH1_Human1.51269618
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50828828
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50757607
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.50738887
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50308398
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49496450
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48083413
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47127046
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47104909
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47097454
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45176870
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43263446
51PHF8_20622854_ChIP-Seq_HELA_Human1.43131737
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41531997
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40706704
54* KDM2B_26808549_Chip-Seq_DND41_Human1.40289384
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39702452
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.39398614
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.39166017
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38966590
59UTX_26944678_Chip-Seq_JUKART_Human1.38313955
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38289736
61CTCF_27219007_Chip-Seq_Bcells_Human1.37681306
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.36607212
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36159869
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34203212
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33317247
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33244598
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31348550
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30750158
69RARB_24833708_ChIP-Seq_LIVER_Mouse1.30066481
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29722271
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29460759
72SMC4_20622854_ChIP-Seq_HELA_Human1.27428597
73STAT1_20625510_ChIP-Seq_HELA_Human1.26883661
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25982261
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.23975823
76SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20765748
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20687386
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.20565164
79P300_27268052_Chip-Seq_Bcells_Human1.19871681
80TCF7_22412390_ChIP-Seq_EML_Mouse1.19220900
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18958633
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16321494
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16132498
84MYC_22102868_ChIP-Seq_BL_Human1.15622822
85CTCF_21964334_Chip-Seq_Bcells_Human1.15590945
86* CTCF_20526341_ChIP-Seq_ESCs_Human1.14341272
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13795032
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13191685
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13143855
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11025059
91* TP63_22573176_ChIP-Seq_HFKS_Human1.09036009
92SPI1_23547873_ChIP-Seq_NB4_Human1.08872365
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07555577
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06787273
95RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05718319
96* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03948623
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03804225
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.03569145
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03504855
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.02525284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.80900174
2MP0003436_decreased_susceptibility_to3.15463381
3MP0005671_abnormal_response_to2.73568258
4MP0003303_peritoneal_inflammation2.58371120
5MP0002148_abnormal_hypersensitivity_rea2.55457289
6MP0001835_abnormal_antigen_presentation2.53853248
7MP0003724_increased_susceptibility_to2.53267925
8MP0009785_altered_susceptibility_to2.28460456
9MP0001790_abnormal_immune_system2.17771616
10MP0005387_immune_system_phenotype2.17771616
11MP0005000_abnormal_immune_tolerance2.17300618
12MP0004510_myositis2.16642025
13MP0000685_abnormal_immune_system2.12741757
14MP0000751_myopathy2.12653537
15MP0002138_abnormal_hepatobiliary_system2.09615056
16MP0003172_abnormal_lysosome_physiology2.08033805
17MP0003279_aneurysm2.04533301
18MP0002419_abnormal_innate_immunity1.96649805
19MP0006082_CNS_inflammation1.96318740
20MP0002933_joint_inflammation1.91757712
21MP0005025_abnormal_response_to1.90622017
22MP0001533_abnormal_skeleton_physiology1.89023720
23MP0009840_abnormal_foam_cell1.87897045
24MP0002723_abnormal_immune_serum1.79447745
25MP0003806_abnormal_nucleotide_metabolis1.78291224
26MP0002837_dystrophic_cardiac_calcinosis1.78019905
27MP0000013_abnormal_adipose_tissue1.74344871
28MP0001800_abnormal_humoral_immune1.73193651
29MP0002254_reproductive_system_inflammat1.71998718
30MP0002452_abnormal_antigen_presenting1.71699267
31MP0002139_abnormal_hepatobiliary_system1.69503498
32MP0000750_abnormal_muscle_regeneration1.68950989
33MP0001542_abnormal_bone_strength1.63663507
34MP0001986_abnormal_taste_sensitivity1.62329479
35MP0000749_muscle_degeneration1.54901911
36MP0009333_abnormal_splenocyte_physiolog1.50178228
37MP0010155_abnormal_intestine_physiology1.49297430
38MP0001819_abnormal_immune_cell1.48014683
39MP0004145_abnormal_muscle_electrophysio1.47582261
40MP0004947_skin_inflammation1.45802489
41MP0001845_abnormal_inflammatory_respons1.44438250
42MP0002420_abnormal_adaptive_immunity1.43810536
43MP0005360_urolithiasis1.42474150
44MP0008438_abnormal_cutaneous_collagen1.40600110
45MP0009764_decreased_sensitivity_to1.40119793
46MP0005451_abnormal_body_composition1.40073588
47MP0008469_abnormal_protein_level1.39652497
48MP0000343_altered_response_to1.39364730
49MP0005167_abnormal_blood-brain_barrier1.36486307
50MP0009384_cardiac_valve_regurgitation1.35956364
51MP0002998_abnormal_bone_remodeling1.33251784
52MP0003075_altered_response_to1.29415751
53MP0004381_abnormal_hair_follicle1.25792942
54MP0009278_abnormal_bone_marrow1.22946936
55MP0002405_respiratory_system_inflammati1.20973489
56MP0000747_muscle_weakness1.20736049
57MP0000003_abnormal_adipose_tissue1.18771926
58MP0005390_skeleton_phenotype1.15613728
59MP0001873_stomach_inflammation1.13323832
60MP0003763_abnormal_thymus_physiology1.11169397
61MP0005166_decreased_susceptibility_to1.10763802
62MP0005330_cardiomyopathy1.10579033
63MP0002163_abnormal_gland_morphology1.08578961
64MP0001958_emphysema1.07596167
65MP0001853_heart_inflammation1.06464433
66MP0005174_abnormal_tail_pigmentation1.04534725
67MP0000604_amyloidosis1.03107146
68MP0003136_yellow_coat_color1.01075168
69MP0000716_abnormal_immune_system0.97247012
70MP0009643_abnormal_urine_homeostasis0.97076469
71MP0000759_abnormal_skeletal_muscle0.97009158
72MP0005365_abnormal_bile_salt0.96899278
73MP0001756_abnormal_urination0.93955803
74MP0004858_abnormal_nervous_system0.93771174
75MP0003191_abnormal_cellular_cholesterol0.93489788
76MP0000733_abnormal_muscle_development0.93081718
77MP0002106_abnormal_muscle_physiology0.89588768
78MP0003300_gastrointestinal_ulcer0.89253445
79MP0003866_abnormal_defecation0.88611757
80MP0005595_abnormal_vascular_smooth0.87216988
81MP0005319_abnormal_enzyme/_coenzyme0.86553113
82MP0003453_abnormal_keratinocyte_physiol0.86289655
83MP0005332_abnormal_amino_acid0.86116892
84MP0003195_calcinosis0.85456732
85MP0001243_abnormal_dermal_layer0.84832607
86MP0003879_abnormal_hair_cell0.83580484
87MP0006036_abnormal_mitochondrial_physio0.83417180
88MP0005379_endocrine/exocrine_gland_phen0.83013174
89MP0005375_adipose_tissue_phenotype0.82776678
90MP0004036_abnormal_muscle_relaxation0.81564793
91MP0003795_abnormal_bone_structure0.80117307
92MP0003045_fibrosis0.79475010
93MP0001765_abnormal_ion_homeostasis0.78877920
94MP0004087_abnormal_muscle_fiber0.78732187
95MP0008875_abnormal_xenobiotic_pharmacok0.78018350
96MP0002429_abnormal_blood_cell0.75456735
97MP0005165_increased_susceptibility_to0.75287952
98MP0003646_muscle_fatigue0.75099591
99MP0002136_abnormal_kidney_physiology0.73547055
100MP0006054_spinal_hemorrhage0.73300562

Predicted human phenotypes

RankGene SetZ-score
1Distal arthrogryposis (HP:0005684)7.11035132
2Round ear (HP:0100830)6.58666509
3Ulnar deviation of the wrist (HP:0003049)6.25189740
4Abnormality of glycolipid metabolism (HP:0010969)4.22631152
5Abnormality of liposaccharide metabolism (HP:0010968)4.22631152
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.22631152
7Malignant hyperthermia (HP:0002047)3.75940502
8Fetal akinesia sequence (HP:0001989)3.67654537
9Calcaneovalgus deformity (HP:0001848)3.67369812
10Thin bony cortex (HP:0002753)3.62042203
11Absent phalangeal crease (HP:0006109)3.58738041
12Dysostosis multiplex (HP:0000943)3.57105785
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.35501640
14Abnormality of polysaccharide metabolism (HP:0011012)3.35501640
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.35501640
16Trismus (HP:0000211)3.34279879
17Joint stiffness (HP:0001387)3.30680120
18Testicular atrophy (HP:0000029)3.29838325
19Deformed tarsal bones (HP:0008119)3.27886134
20Aplasia of the musculature (HP:0100854)3.27413734
21Urinary glycosaminoglycan excretion (HP:0003541)3.14727415
22Mucopolysacchariduria (HP:0008155)3.14727415
23Popliteal pterygium (HP:0009756)3.10109913
24Vacuolated lymphocytes (HP:0001922)2.90753956
25Abnormal finger flexion creases (HP:0006143)2.85669313
26Myopathic facies (HP:0002058)2.83023329
27Asymmetric septal hypertrophy (HP:0001670)2.73797442
28Amniotic constriction ring (HP:0009775)2.73077277
29Abnormality of placental membranes (HP:0011409)2.73077277
30Systemic lupus erythematosus (HP:0002725)2.69684018
31Myositis (HP:0100614)2.67838616
32Nemaline bodies (HP:0003798)2.61133448
33Elevated erythrocyte sedimentation rate (HP:0003565)2.59108520
34Mesangial abnormality (HP:0001966)2.58995271
35J-shaped sella turcica (HP:0002680)2.46637610
36Increased cerebral lipofuscin (HP:0011813)2.43692655
37Akinesia (HP:0002304)2.40952307
38Optic neuritis (HP:0100653)2.38766400
39Retrobulbar optic neuritis (HP:0100654)2.38766400
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37481642
41Loss of speech (HP:0002371)2.37108904
42Bulbar palsy (HP:0001283)2.36802038
43Orchitis (HP:0100796)2.35101036
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.31332460
45Type 1 muscle fiber predominance (HP:0003803)2.27214660
46Neoplasm of the heart (HP:0100544)2.22721750
47Facial diplegia (HP:0001349)2.21432399
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19722140
49Stomatitis (HP:0010280)2.18989215
50Muscle fiber inclusion bodies (HP:0100299)2.18277991
51Prolonged neonatal jaundice (HP:0006579)2.17548548
52Hemoptysis (HP:0002105)2.15738668
53Enlarged epiphyses (HP:0010580)2.15107283
54Stridor (HP:0010307)2.13138677
55Breech presentation (HP:0001623)2.11936170
56Exercise-induced myalgia (HP:0003738)2.11217367
57Recurrent bacterial skin infections (HP:0005406)2.09312357
58Eczematoid dermatitis (HP:0000976)2.08261685
59Increased serum ferritin (HP:0003281)2.06713806
60Cervical subluxation (HP:0003308)2.06426326
61Type 2 muscle fiber atrophy (HP:0003554)2.03926544
62Muscle fiber atrophy (HP:0100295)1.99399253
63Symphalangism affecting the phalanges of the hand (HP:0009773)1.98215704
64Recurrent abscess formation (HP:0002722)1.97959361
65Gastrointestinal infarctions (HP:0005244)1.96306554
66Metatarsus adductus (HP:0001840)1.95907699
67Nuclear cataract (HP:0100018)1.95831709
68Pulmonary infiltrates (HP:0002113)1.94000711
69Hip contracture (HP:0003273)1.93612679
70Hematochezia (HP:0002573)1.93206091
71Abnormality of macrophages (HP:0004311)1.91735536
72Pustule (HP:0200039)1.85534899
73Recurrent cutaneous fungal infections (HP:0011370)1.82699575
74Chronic mucocutaneous candidiasis (HP:0002728)1.82699575
75Recurrent fungal infections (HP:0002841)1.81990556
76Rib fusion (HP:0000902)1.80740005
77Delayed epiphyseal ossification (HP:0002663)1.79608332
78Abnormality of the calcaneus (HP:0008364)1.76988693
79Easy fatigability (HP:0003388)1.76744709
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73160319
81Increased muscle lipid content (HP:0009058)1.72859825
82Dicarboxylic aciduria (HP:0003215)1.72343802
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72343802
84Abnormality of the costochondral junction (HP:0000919)1.70756153
85Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70257241
86Hypoplastic heart (HP:0001961)1.69688663
87Progressive neurologic deterioration (HP:0002344)1.68593347
88Colitis (HP:0002583)1.68523874
89Abnormality of the neuromuscular junction (HP:0003398)1.66817494
90Fatigable weakness (HP:0003473)1.66817494
91Emphysema (HP:0002097)1.66627441
92Recurrent skin infections (HP:0001581)1.65904746
93Muscle fiber splitting (HP:0003555)1.64573493
94Petechiae (HP:0000967)1.64562518
95Abnormality of transition element cation homeostasis (HP:0011030)1.64311707
96Abnormality of iron homeostasis (HP:0011031)1.63220594
97Mediastinal lymphadenopathy (HP:0100721)1.60956925
98Hepatocellular necrosis (HP:0001404)1.59193262
99Mitochondrial inheritance (HP:0001427)1.58418722
100Autoimmune thrombocytopenia (HP:0001973)1.56730654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK12.80973256
2TXK2.76434492
3MAPK152.55916123
4TBK12.39608501
5MAP4K12.39127636
6NME22.39106441
7MAP3K142.36410319
8TRIB32.28212905
9BLK2.14278307
10TNK22.10233717
11IRAK31.97083670
12ERN11.91261251
13MAP2K61.90743020
14IKBKB1.86591095
15MAPKAPK31.85326979
16SMG11.85117918
17MUSK1.69987312
18GRK61.64196132
19SIK11.63809507
20KDR1.62931880
21PRKD31.56835416
22ZAP701.54832425
23DDR21.53952303
24RIPK41.53761740
25IKBKE1.53216418
26PRKD21.52374103
27VRK21.52273313
28MAP3K111.49102828
29TYK21.48845467
30MAP2K31.48455738
31KIT1.48399696
32MAP3K131.40105032
33FES1.34813120
34ADRBK21.31605851
35MAP2K21.30699134
36IRAK41.20954978
37PIK3CG1.19209028
38TESK21.15705791
39WNK41.14625020
40JAK31.10091780
41TAOK31.09148187
42CHUK1.08019405
43EPHB11.06615958
44GRK71.05089408
45BCKDK1.04088264
46SYK1.00024073
47STK160.99694703
48MOS0.98285758
49CSK0.96776525
50TGFBR20.96397290
51MAPK70.96373933
52TAOK20.96220487
53BTK0.94016544
54PIM20.94001463
55MAPK120.90259382
56SIK20.90038551
57MAP3K70.89064551
58TESK10.87607355
59OBSCN0.87537049
60ABL20.83869742
61NUAK10.82995232
62PHKG20.82176771
63PHKG10.82176771
64ITK0.81380122
65CDC42BPA0.80260523
66RPS6KA20.78688718
67CSF1R0.76792520
68MATK0.76418852
69NME10.76356214
70LYN0.76092990
71MAP3K30.76026112
72FGFR40.75466959
73RPS6KC10.68872266
74RPS6KL10.68872266
75HIPK20.68825237
76MARK20.66882012
77RIPK10.66107175
78DAPK30.65096325
79DAPK20.65078213
80RPS6KA60.63210629
81JAK10.62288823
82PDPK10.61222207
83LCK0.60814726
84TRPM70.60187893
85HCK0.57781824
86TIE10.54896482
87DAPK10.53798324
88LIMK10.49733327
89MAP3K10.49096184
90MAPK110.47515329
91PDK10.46344521
92PRKAA20.46165173
93MAPKAPK20.46065584
94TEC0.45645711
95TAOK10.45474546
96MYLK0.45066532
97GRK10.43078669
98ILK0.42973726
99EPHA30.42882533
100MAPK40.38632010

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.36146291
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.60489264
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.07649939
4Asthma_Homo sapiens_hsa053103.03118558
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.91980747
6Allograft rejection_Homo sapiens_hsa053302.73807859
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50075726
8Graft-versus-host disease_Homo sapiens_hsa053322.45147592
9Sulfur relay system_Homo sapiens_hsa041222.37834010
10Autoimmune thyroid disease_Homo sapiens_hsa053202.32371240
11Lysosome_Homo sapiens_hsa041422.31721518
12Sulfur metabolism_Homo sapiens_hsa009202.19071412
13Staphylococcus aureus infection_Homo sapiens_hsa051502.14280067
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11999570
15Rheumatoid arthritis_Homo sapiens_hsa053232.08511377
16Type I diabetes mellitus_Homo sapiens_hsa049402.02947083
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02320870
18Leishmaniasis_Homo sapiens_hsa051401.98306370
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.84406283
20Osteoclast differentiation_Homo sapiens_hsa043801.63109912
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56007916
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51115502
23Primary immunodeficiency_Homo sapiens_hsa053401.46434861
24Pertussis_Homo sapiens_hsa051331.46016076
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43556308
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43095379
27Antigen processing and presentation_Homo sapiens_hsa046121.35521517
28Tuberculosis_Homo sapiens_hsa051521.31162836
29Oxidative phosphorylation_Homo sapiens_hsa001901.28724061
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27271261
31Hematopoietic cell lineage_Homo sapiens_hsa046401.27196978
32Malaria_Homo sapiens_hsa051441.25065358
33TNF signaling pathway_Homo sapiens_hsa046681.23378048
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19763995
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19351201
36Toxoplasmosis_Homo sapiens_hsa051451.09502875
37Fructose and mannose metabolism_Homo sapiens_hsa000511.02161529
38B cell receptor signaling pathway_Homo sapiens_hsa046620.93283125
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89696897
40Viral myocarditis_Homo sapiens_hsa054160.83073824
41Mineral absorption_Homo sapiens_hsa049780.79742258
42Renin-angiotensin system_Homo sapiens_hsa046140.78920459
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78620342
44Herpes simplex infection_Homo sapiens_hsa051680.77834937
45Sphingolipid metabolism_Homo sapiens_hsa006000.77665552
46Influenza A_Homo sapiens_hsa051640.73884778
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.73684801
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71312535
49Legionellosis_Homo sapiens_hsa051340.67245068
50Collecting duct acid secretion_Homo sapiens_hsa049660.67158104
51Arachidonic acid metabolism_Homo sapiens_hsa005900.65386329
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.65374435
53Parkinsons disease_Homo sapiens_hsa050120.64759397
54Notch signaling pathway_Homo sapiens_hsa043300.64462488
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64453025
56Tryptophan metabolism_Homo sapiens_hsa003800.64024280
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61413020
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.58126608
59PPAR signaling pathway_Homo sapiens_hsa033200.56611092
60Hepatitis C_Homo sapiens_hsa051600.56537175
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55603326
62Alzheimers disease_Homo sapiens_hsa050100.55366824
63T cell receptor signaling pathway_Homo sapiens_hsa046600.54813314
64Linoleic acid metabolism_Homo sapiens_hsa005910.54658418
65African trypanosomiasis_Homo sapiens_hsa051430.51928941
66Ovarian steroidogenesis_Homo sapiens_hsa049130.50764663
67Phagosome_Homo sapiens_hsa041450.50751594
68Acute myeloid leukemia_Homo sapiens_hsa052210.49426049
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46794558
70Ribosome_Homo sapiens_hsa030100.46486975
71Measles_Homo sapiens_hsa051620.46430879
72Galactose metabolism_Homo sapiens_hsa000520.45778666
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45644372
74Chemokine signaling pathway_Homo sapiens_hsa040620.45606220
75Peroxisome_Homo sapiens_hsa041460.45385080
76Regulation of autophagy_Homo sapiens_hsa041400.45028889
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.41805210
78Glutathione metabolism_Homo sapiens_hsa004800.41600686
79Chemical carcinogenesis_Homo sapiens_hsa052040.40826865
80VEGF signaling pathway_Homo sapiens_hsa043700.40390114
81Cardiac muscle contraction_Homo sapiens_hsa042600.39976602
82Insulin resistance_Homo sapiens_hsa049310.39134383
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37300028
84Vitamin digestion and absorption_Homo sapiens_hsa049770.36653563
85Salmonella infection_Homo sapiens_hsa051320.34338455
86Systemic lupus erythematosus_Homo sapiens_hsa053220.30825645
87Epstein-Barr virus infection_Homo sapiens_hsa051690.30339688
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30269320
89Ether lipid metabolism_Homo sapiens_hsa005650.30031492
90Protein digestion and absorption_Homo sapiens_hsa049740.28600464
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28542136
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.28152857
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.27900166
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27792878
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27537482
96Amoebiasis_Homo sapiens_hsa051460.27334075
97Shigellosis_Homo sapiens_hsa051310.25217454
98Phototransduction_Homo sapiens_hsa047440.24052876
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22301865
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21285648

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