MYL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.49820072
2viral transcription (GO:0019083)5.41306138
3ribosomal small subunit assembly (GO:0000028)5.22014049
4translational termination (GO:0006415)5.15475076
5ATP synthesis coupled proton transport (GO:0015986)5.03932382
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.03932382
7ribosomal small subunit biogenesis (GO:0042274)4.91016925
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.72737101
9protein targeting to ER (GO:0045047)4.71435696
10cotranslational protein targeting to membrane (GO:0006613)4.69337018
11protein maturation by protein folding (GO:0022417)4.69222712
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.47895181
13protein localization to endoplasmic reticulum (GO:0070972)4.43288001
14viral life cycle (GO:0019058)4.24066715
15translational elongation (GO:0006414)4.23441035
16cellular protein complex disassembly (GO:0043624)4.04040750
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.89074401
18proteasome assembly (GO:0043248)3.87167894
19sequestering of actin monomers (GO:0042989)3.68960996
20respiratory electron transport chain (GO:0022904)3.66747420
21type B pancreatic cell proliferation (GO:0044342)3.65074237
22electron transport chain (GO:0022900)3.58340484
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56685463
24protein targeting to membrane (GO:0006612)3.52936438
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49158252
26barbed-end actin filament capping (GO:0051016)3.39264799
27translational initiation (GO:0006413)3.37745389
28positive regulation of endothelial cell apoptotic process (GO:2000353)3.36994091
29Golgi transport vesicle coating (GO:0048200)3.36392642
30COPI coating of Golgi vesicle (GO:0048205)3.36392642
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35706337
32negative regulation of ligase activity (GO:0051352)3.35284839
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35284839
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29713959
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29713959
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29713959
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.29205462
38membrane raft organization (GO:0031579)3.28950986
39maturation of SSU-rRNA (GO:0030490)3.26744569
40negative regulation of nitric-oxide synthase activity (GO:0051001)3.26524351
41neutrophil activation involved in immune response (GO:0002283)3.23915945
42protein neddylation (GO:0045116)3.21768896
43wound healing, spreading of epidermal cells (GO:0035313)3.21613693
44protein complex disassembly (GO:0043241)3.20693584
45chaperone-mediated protein transport (GO:0072321)3.19447523
46cell adhesion mediated by integrin (GO:0033627)3.17626565
47platelet dense granule organization (GO:0060155)3.12496922
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12229879
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.12229879
50cellular response to zinc ion (GO:0071294)3.08225912
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08074551
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07282172
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.04195235
54actin filament depolymerization (GO:0030042)3.01210699
55positive regulation of TOR signaling (GO:0032008)3.00436794
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00369526
57regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99476107
58protein retention in ER lumen (GO:0006621)2.97989804
59macromolecular complex disassembly (GO:0032984)2.97750628
60regulation of cellular amine metabolic process (GO:0033238)2.97046527
61establishment of viral latency (GO:0019043)2.94450015
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88991758
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88746399
64endothelial cell chemotaxis (GO:0035767)2.88244677
65regulation of mononuclear cell migration (GO:0071675)2.84242148
66regulation of integrin-mediated signaling pathway (GO:2001044)2.82126565
67eosinophil chemotaxis (GO:0048245)2.80724196
68positive regulation of actin filament depolymerization (GO:0030836)2.77925088
69glomerular visceral epithelial cell development (GO:0072015)2.76847014
70protein complex biogenesis (GO:0070271)2.76619291
71hydrogen transport (GO:0006818)2.75409362
72mitotic nuclear envelope reassembly (GO:0007084)2.71974625
73nuclear envelope reassembly (GO:0031468)2.71974625
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71784205
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71714413
76viral protein processing (GO:0019082)2.67933804
77heart contraction (GO:0060047)2.67715044
78heart process (GO:0003015)2.67715044
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67418436
80vascular endothelial growth factor signaling pathway (GO:0038084)2.67289026
81translation (GO:0006412)2.66935025
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66391905
83wound healing, spreading of cells (GO:0044319)2.64043950
84chondrocyte proliferation (GO:0035988)2.61362168
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61114062
86positive regulation of cell cycle arrest (GO:0071158)2.60951898
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57428732
88platelet aggregation (GO:0070527)2.57123844
89neuron projection extension involved in neuron projection guidance (GO:1902284)2.55837528
90axon extension involved in axon guidance (GO:0048846)2.55837528
91establishment of protein localization to membrane (GO:0090150)2.52379541
92epithelial cell-cell adhesion (GO:0090136)2.52167239
93positive regulation of monocyte chemotaxis (GO:0090026)2.51740819
94membrane budding (GO:0006900)2.51693256
95regulation of protein heterodimerization activity (GO:0043497)2.51459995
96positive regulation of ligase activity (GO:0051351)2.50672789
97fibril organization (GO:0097435)2.49897714
98GDP-mannose metabolic process (GO:0019673)2.49816078
99mesodermal cell differentiation (GO:0048333)2.49702179
100endodermal cell differentiation (GO:0035987)2.49682395
101lymph vessel development (GO:0001945)2.49665537
102eosinophil migration (GO:0072677)2.48816374
103extracellular fibril organization (GO:0043206)2.48307642
104activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.47934854
105regulation of metalloenzyme activity (GO:0048552)2.47164687
106protein heterotrimerization (GO:0070208)2.47160005
107positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.47092136
108substrate-dependent cell migration (GO:0006929)2.47065021
109glomerular epithelial cell development (GO:0072310)2.47019297
110collagen fibril organization (GO:0030199)2.46558009
111inner mitochondrial membrane organization (GO:0007007)2.46414893
112negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.46373446
113regulation of monocyte chemotaxis (GO:0090025)2.44551791
114positive regulation of interleukin-8 secretion (GO:2000484)2.41759532
115hypotonic response (GO:0006971)2.41493267
116negative regulation of smooth muscle cell migration (GO:0014912)2.40629318
117glial cell migration (GO:0008347)2.39672486
118antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.38183380
119keratan sulfate catabolic process (GO:0042340)2.37911921
120hydrogen ion transmembrane transport (GO:1902600)2.37694427
121adhesion of symbiont to host cell (GO:0044650)2.37683491
122virion attachment to host cell (GO:0019062)2.37683491
123basement membrane organization (GO:0071711)2.37122576
124cellular response to interferon-alpha (GO:0035457)2.36967665
125establishment of integrated proviral latency (GO:0075713)2.36851197
126virion assembly (GO:0019068)2.36191481
127glomerular basement membrane development (GO:0032836)2.35850943
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35560893
129hydrogen peroxide metabolic process (GO:0042743)2.35085256
130negative regulation of axon guidance (GO:1902668)2.34678803
131negative regulation of striated muscle cell apoptotic process (GO:0010664)2.33115792
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.32518238
133ATP biosynthetic process (GO:0006754)2.30756286
134regulation of cellular amino acid metabolic process (GO:0006521)2.29513866
135ribosomal large subunit biogenesis (GO:0042273)2.29169671
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24025172
137hydrogen peroxide catabolic process (GO:0042744)2.23255094
138purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.20138763
139myeloid cell homeostasis (GO:0002262)2.19447560
140skin morphogenesis (GO:0043589)2.18825861
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18819497
142protein targeting (GO:0006605)2.18333032
143DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.18081893
144endothelial tube morphogenesis (GO:0061154)2.16778691
145morphogenesis of an endothelium (GO:0003159)2.16778691
146monocyte chemotaxis (GO:0002548)2.15002202
147negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.13436634
148surfactant homeostasis (GO:0043129)2.13434774
149purine nucleoside triphosphate biosynthetic process (GO:0009145)2.13350220
150renal filtration (GO:0097205)2.12632136
151hemidesmosome assembly (GO:0031581)2.12142186
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.10920587
153antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.10920587
154signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.09669273
155intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.09669273
156endocardial cushion development (GO:0003197)2.09443843
157response to interferon-beta (GO:0035456)2.08918265
158proton transport (GO:0015992)2.07557771
159protein localization to cell surface (GO:0034394)2.03788292

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.05089374
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.13063630
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.16138482
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67618948
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18259879
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16934301
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.07021674
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.95240043
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76061493
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60006478
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50825135
12CLOCK_20551151_ChIP-Seq_293T_Human2.42675444
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38030364
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.35529448
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26910679
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25383639
17* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21821214
18* ELK1_22589737_ChIP-Seq_MCF10A_Human2.21345333
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.17864950
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11709532
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.07644203
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.05959541
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04247628
24SOX2_20726797_ChIP-Seq_SW620_Human2.01264803
25* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.95285346
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87369180
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85962715
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.83341653
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78645964
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71912353
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67545437
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.67018482
33* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.64364574
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.62931463
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60992496
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60670210
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60670210
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.55927525
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.54968658
40* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52253094
41CJUN_26792858_Chip-Seq_BT549_Human1.49665921
42EOMES_21245162_ChIP-Seq_HESCs_Human1.49314700
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48161525
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.47525721
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44828415
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43168969
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.42855680
48SOX2_18692474_ChIP-Seq_MEFs_Mouse1.42833061
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40811379
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37543729
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37417172
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36837481
53* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36502051
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36059933
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33598955
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31661217
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.28830322
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28206335
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23292798
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.22602483
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21705726
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20387505
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20387505
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20262816
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19839571
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19752287
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19101740
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18911552
69ATF3_27146783_Chip-Seq_COLON_Human1.18741838
70RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18240206
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17432453
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17257293
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16668124
74* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.15454360
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.15224597
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14422801
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14382213
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13763666
79SA1_22415368_ChIP-Seq_MEFs_Mouse1.13312346
80* SPI1_23547873_ChIP-Seq_NB4_Human1.12519798
81* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12324844
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.11539590
83* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11347228
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09795788
85* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09716520
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.09631002
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.09284345
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08925134
89* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08848053
90* RACK7_27058665_Chip-Seq_MCF-7_Human1.08689976
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07991378
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07674894
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07392354
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07290753
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06536772
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06427488
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05900647
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.04953726
99ZNF263_19887448_ChIP-Seq_K562_Human1.04502639
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04375539
101* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04202475
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03896072
103* DCP1A_22483619_ChIP-Seq_HELA_Human1.03468990
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03153879
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02645233
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02372909
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.01682656
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01656451
109SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01449708
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.00863349
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00615043
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.99326837
113NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98775607
114ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98306527
115* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98251650
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98050390
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97593006
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97548084
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97536206
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96767490
121* SOX17_20123909_ChIP-Seq_XEN_Mouse0.96439731
122THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96308002
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96300740
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95654507
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95543049
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94062485
127* VDR_24763502_ChIP-Seq_THP-1_Human0.93522486
128ELF5_23300383_ChIP-Seq_T47D_Human0.92749922
129* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92558872
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92264914
131LXR_22292898_ChIP-Seq_THP-1_Human0.91633255
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91171587
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89730604
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89252838
135* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88816188
136* XRN2_22483619_ChIP-Seq_HELA_Human0.88439931
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88425796
138GATA4_25053715_ChIP-Seq_YYC3_Human0.87739447
139* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86703183
140YY1_21170310_ChIP-Seq_MESCs_Mouse0.86251681
141* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85834931
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85589659
143TP53_22127205_ChIP-Seq_IMR90_Human0.85156963
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83781929
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83003561
146STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81787341

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.00731227
2MP0005275_abnormal_skin_tensile3.30402876
3MP0004272_abnormal_basement_membrane3.24637736
4MP0010030_abnormal_orbit_morphology3.20698751
5MP0006054_spinal_hemorrhage2.89250703
6MP0001958_emphysema2.77874925
7MP0009379_abnormal_foot_pigmentation2.70600636
8MP0003279_aneurysm2.59169905
9MP0003566_abnormal_cell_adhesion2.42122174
10MP0001879_abnormal_lymphatic_vessel2.36821763
11MP0005503_abnormal_tendon_morphology2.25481158
12MP0005623_abnormal_meninges_morphology2.22122133
13MP0003724_increased_susceptibility_to2.17778508
14MP0003011_delayed_dark_adaptation1.93718226
15MP0009840_abnormal_foam_cell1.84839647
16MP0001542_abnormal_bone_strength1.84459406
17MP0009384_cardiac_valve_regurgitation1.83881568
18MP0002295_abnormal_pulmonary_circulatio1.81273099
19MP0009785_altered_susceptibility_to1.79033536
20MP0002148_abnormal_hypersensitivity_rea1.76785220
21MP0010386_abnormal_urinary_bladder1.75265793
22MP0002877_abnormal_melanocyte_morpholog1.74152123
23MP0005023_abnormal_wound_healing1.68511344
24MP0005164_abnormal_response_to1.63857575
25MP0003705_abnormal_hypodermis_morpholog1.62815144
26MP0002909_abnormal_adrenal_gland1.60489322
27MP0002166_altered_tumor_susceptibility1.59856377
28MP0004084_abnormal_cardiac_muscle1.58420738
29MP0005367_renal/urinary_system_phenotyp1.57845006
30MP0000516_abnormal_urinary_system1.57845006
31MP0003806_abnormal_nucleotide_metabolis1.54866869
32MP0001835_abnormal_antigen_presentation1.53899094
33MP0003091_abnormal_cell_migration1.53567034
34MP0000013_abnormal_adipose_tissue1.47186419
35MP0010368_abnormal_lymphatic_system1.46918623
36MP0003436_decreased_susceptibility_to1.45707883
37MP0003191_abnormal_cellular_cholesterol1.44677396
38MP0001905_abnormal_dopamine_level1.44297022
39MP0001533_abnormal_skeleton_physiology1.43206023
40MP0000343_altered_response_to1.40402349
41MP0004883_abnormal_blood_vessel1.39690923
42MP0005058_abnormal_lysosome_morphology1.38072312
43MP0000685_abnormal_immune_system1.37644048
44MP0010234_abnormal_vibrissa_follicle1.36968451
45MP0000858_altered_metastatic_potential1.33409155
46MP0008004_abnormal_stomach_pH1.31894874
47MP0004510_myositis1.30695280
48MP0005167_abnormal_blood-brain_barrier1.27757624
49MP0000767_abnormal_smooth_muscle1.26499382
50MP0002006_tumorigenesis1.26249899
51MP0002933_joint_inflammation1.26165023
52MP0005197_abnormal_uvea_morphology1.25548364
53MP0003950_abnormal_plasma_membrane1.23053727
54MP0000538_abnormal_urinary_bladder1.21499871
55MP0005025_abnormal_response_to1.20372075
56MP0003828_pulmonary_edema1.18616651
57MP0000750_abnormal_muscle_regeneration1.18589432
58MP0005000_abnormal_immune_tolerance1.18230305
59MP0002060_abnormal_skin_morphology1.17599952
60MP0003448_altered_tumor_morphology1.17011152
61MP0000249_abnormal_blood_vessel1.16507562
62MP0002419_abnormal_innate_immunity1.15998743
63MP0005084_abnormal_gallbladder_morpholo1.15380475
64MP0009053_abnormal_anal_canal1.12758915
65MP0001299_abnormal_eye_distance/1.12327410
66MP0006082_CNS_inflammation1.08626820
67MP0005408_hypopigmentation1.08514980
68MP0009333_abnormal_splenocyte_physiolog1.08359638
69MP0005165_increased_susceptibility_to1.08235746
70MP0003186_abnormal_redox_activity1.08171706
71MP0010155_abnormal_intestine_physiology1.08160937
72MP0001727_abnormal_embryo_implantation1.07559851
73MP0005257_abnormal_intraocular_pressure1.06385368
74MP0001756_abnormal_urination1.04112762
75MP0002998_abnormal_bone_remodeling1.03943295
76MP0003329_amyloid_beta_deposits1.02521975
77MP0005193_abnormal_anterior_eye1.02369949
78MP0004947_skin_inflammation1.02277995
79MP0005390_skeleton_phenotype1.01233153
80MP0002282_abnormal_trachea_morphology1.00770269
81MP0004036_abnormal_muscle_relaxation1.00675057
82MP0003075_altered_response_to1.00471170
83MP0003283_abnormal_digestive_organ1.00201832
84MP0002972_abnormal_cardiac_muscle0.99774978
85MP0005387_immune_system_phenotype0.99404067
86MP0001790_abnormal_immune_system0.99404067
87MP0003941_abnormal_skin_development0.98688840
88MP0005595_abnormal_vascular_smooth0.98630099
89MP0010352_gastrointestinal_tract_polyps0.98237636
90MP0005671_abnormal_response_to0.97794865
91MP0008775_abnormal_heart_ventricle0.95424210
92MP0003303_peritoneal_inflammation0.95300130
93MP0002452_abnormal_antigen_presenting0.94206701
94MP0004019_abnormal_vitamin_homeostasis0.92950840
95MP0006138_congestive_heart_failure0.92920508
96MP0001529_abnormal_vocalization0.91837474
97MP0005330_cardiomyopathy0.91378715
98MP0003866_abnormal_defecation0.91146677
99MP0001664_abnormal_digestion0.91028505
100MP0003300_gastrointestinal_ulcer0.90787164
101MP0000465_gastrointestinal_hemorrhage0.90536322
102MP0001348_abnormal_lacrimal_gland0.89234911
103MP0002405_respiratory_system_inflammati0.88831030
104MP0000749_muscle_degeneration0.88021307
105MP0000604_amyloidosis0.86779298
106MP0005508_abnormal_skeleton_morphology0.86636327
107MP0006276_abnormal_autonomic_nervous0.86422389
108MP0002896_abnormal_bone_mineralization0.85767162
109MP0000537_abnormal_urethra_morphology0.85225258
110MP0001819_abnormal_immune_cell0.84878003
111MP0001243_abnormal_dermal_layer0.84502085
112MP0002420_abnormal_adaptive_immunity0.83187125
113MP0001845_abnormal_inflammatory_respons0.81507543
114MP0000358_abnormal_cell_content/0.80985050
115MP0000762_abnormal_tongue_morphology0.80388285
116MP0002796_impaired_skin_barrier0.80338270
117MP0002136_abnormal_kidney_physiology0.80251647
118MP0003315_abnormal_perineum_morphology0.80243090
119MP0001614_abnormal_blood_vessel0.79897157
120MP0005385_cardiovascular_system_phenoty0.79660541
121MP0001544_abnormal_cardiovascular_syste0.79660541
122MP0000462_abnormal_digestive_system0.78098827
123MP0005083_abnormal_biliary_tract0.78039983
124MP0005464_abnormal_platelet_physiology0.78024204
125MP0003385_abnormal_body_wall0.77078980
126MP0001663_abnormal_digestive_system0.75405536
127MP0001849_ear_inflammation0.75039031
128MP0009250_abnormal_appendicular_skeleto0.72866747
129MP0004858_abnormal_nervous_system0.71497527
130MP0001853_heart_inflammation0.70144357
131MP0003638_abnormal_response/metabolism_0.69543699
132MP0000751_myopathy0.69230278
133MP0000534_abnormal_ureter_morphology0.67613192
134MP0002653_abnormal_ependyma_morphology0.66895272
135MP0000230_abnormal_systemic_arterial0.66373625
136MP0002822_catalepsy0.64382166
137MP0000163_abnormal_cartilage_morphology0.61451345
138MP0006072_abnormal_retinal_apoptosis0.60863737
139MP0002736_abnormal_nociception_after0.59402452
140MP0009764_decreased_sensitivity_to0.59094195
141MP0009780_abnormal_chondrocyte_physiolo0.58939395
142MP0005166_decreased_susceptibility_to0.58175229
143MP0009643_abnormal_urine_homeostasis0.57626201
144MP0003795_abnormal_bone_structure0.56722307

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)4.76029377
2Aortic dissection (HP:0002647)4.63295205
3Premature rupture of membranes (HP:0001788)4.38153691
4Protrusio acetabuli (HP:0003179)4.24944579
5Abnormality of glycolipid metabolism (HP:0010969)3.62928919
6Abnormality of liposaccharide metabolism (HP:0010968)3.62928919
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.62928919
8Abnormality of cells of the erythroid lineage (HP:0012130)3.54960254
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22602430
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22602430
11Vertebral compression fractures (HP:0002953)3.13011005
12Acute necrotizing encephalopathy (HP:0006965)3.05375298
13Abnormality of dentin (HP:0010299)3.05256646
14Atrophic scars (HP:0001075)3.02415700
15Peritonitis (HP:0002586)2.97430005
16Nuclear cataract (HP:0100018)2.93025706
17Cerebral aneurysm (HP:0004944)2.91774200
18Increased intramyocellular lipid droplets (HP:0012240)2.85025227
19Abnormal number of erythroid precursors (HP:0012131)2.81341369
20Mitochondrial inheritance (HP:0001427)2.74917931
21Abnormal hemoglobin (HP:0011902)2.70209070
22Dilatation of the ascending aorta (HP:0005111)2.68676273
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.68338821
24Osteolytic defects of the hand bones (HP:0009699)2.68338821
25Abnormal mitochondria in muscle tissue (HP:0008316)2.66890334
26Ankle contracture (HP:0006466)2.66113977
27Reticulocytopenia (HP:0001896)2.63823613
28Vacuolated lymphocytes (HP:0001922)2.62346107
29Cervical subluxation (HP:0003308)2.59040793
30Eczematoid dermatitis (HP:0000976)2.57218614
31Axonal loss (HP:0003447)2.53295035
32Increased muscle lipid content (HP:0009058)2.53281874
33Progressive macrocephaly (HP:0004481)2.51086778
34Wormian bones (HP:0002645)2.45979032
35Vascular tortuosity (HP:0004948)2.45008836
363-Methylglutaconic aciduria (HP:0003535)2.44549409
37Joint stiffness (HP:0001387)2.40515856
38Type 1 muscle fiber predominance (HP:0003803)2.36723851
39Recurrent abscess formation (HP:0002722)2.35281909
40Increased hepatocellular lipid droplets (HP:0006565)2.32949455
41Fragile skin (HP:0001030)2.32388960
42Cerebral edema (HP:0002181)2.30578966
43Broad metatarsal (HP:0001783)2.29632560
44Interstitial pulmonary disease (HP:0006530)2.28231702
45Soft skin (HP:0000977)2.25844594
46Delayed gross motor development (HP:0002194)2.25784594
47Spinal rigidity (HP:0003306)2.24361529
48Elevated erythrocyte sedimentation rate (HP:0003565)2.22853895
49Right ventricular cardiomyopathy (HP:0011663)2.22437574
50Congenital, generalized hypertrichosis (HP:0004540)2.22108355
51Gastrointestinal dysmotility (HP:0002579)2.22063784
52Aplastic anemia (HP:0001915)2.18013569
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17442564
54Acute encephalopathy (HP:0006846)2.16617217
55Bone cyst (HP:0012062)2.16040035
56Conjunctival hamartoma (HP:0100780)2.14064016
57Abnormality of renal resorption (HP:0011038)2.13563783
58Stridor (HP:0010307)2.13412737
59Bicuspid aortic valve (HP:0001647)2.13170292
60Prolonged neonatal jaundice (HP:0006579)2.13102908
61Amniotic constriction ring (HP:0009775)2.12408168
62Abnormality of placental membranes (HP:0011409)2.12408168
63Exertional dyspnea (HP:0002875)2.12043644
64Abnormality of macrophages (HP:0004311)2.10195290
65Limb-girdle muscle atrophy (HP:0003797)2.09319616
66Increased density of long bones (HP:0006392)2.07211514
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06905186
68Renal Fanconi syndrome (HP:0001994)2.05206279
69Progressive neurologic deterioration (HP:0002344)2.04198185
70Lipid accumulation in hepatocytes (HP:0006561)2.03747968
71Arterial tortuosity (HP:0005116)2.03358206
72Polyphagia (HP:0002591)2.03102043
73Abnormal pupillary function (HP:0007686)2.01676429
74Bladder diverticulum (HP:0000015)1.98511794
75Increased CSF lactate (HP:0002490)1.98141772
76Macrocytic anemia (HP:0001972)1.98086198
77Pulmonary artery stenosis (HP:0004415)1.97544919
78Cardiovascular calcification (HP:0011915)1.97478025
79Dysostosis multiplex (HP:0000943)1.97176073
80Purpura (HP:0000979)1.96691580
81Rough bone trabeculation (HP:0100670)1.95015589
82Generalized aminoaciduria (HP:0002909)1.94107127
83Hepatosplenomegaly (HP:0001433)1.93618470
84Short nail (HP:0001799)1.93038539
85Hepatocellular necrosis (HP:0001404)1.92780657
86Mesangial abnormality (HP:0001966)1.92599525
87Respiratory failure (HP:0002878)1.91985197
88Tetraparesis (HP:0002273)1.91860848
89Mitral stenosis (HP:0001718)1.91496830
90Thrombocytosis (HP:0001894)1.90321280
91Petechiae (HP:0000967)1.89540683
92Scapular winging (HP:0003691)1.89453067
93Nonimmune hydrops fetalis (HP:0001790)1.88317631
94Fragile nails (HP:0001808)1.87968574
95Neonatal short-limb short stature (HP:0008921)1.87575997
96Radial bowing (HP:0002986)1.86909317
97Increased mean platelet volume (HP:0011877)1.86432764
98Blue sclerae (HP:0000592)1.86215611
99Increased IgM level (HP:0003496)1.85505102
100Pallor (HP:0000980)1.84294167
101Concave nail (HP:0001598)1.83968678
102Woolly hair (HP:0002224)1.83755548
103Trismus (HP:0000211)1.83750044
104Irregular vertebral endplates (HP:0003301)1.83299593
105Exercise intolerance (HP:0003546)1.83156952
106Abnormality of the fetal cardiovascular system (HP:0010948)1.82705025
107Abnormal umbilical cord blood vessels (HP:0011403)1.82705025
108Single umbilical artery (HP:0001195)1.82705025
109Follicular hyperkeratosis (HP:0007502)1.81899993
110Thin bony cortex (HP:0002753)1.81672253
111Congenital ichthyosiform erythroderma (HP:0007431)1.80908161
112Hydroureter (HP:0000072)1.80378000
113Beaking of vertebral bodies (HP:0004568)1.80090720
114Aortic regurgitation (HP:0001659)1.77646231
115Short hallux (HP:0010109)1.77214130
116Recurrent bacterial skin infections (HP:0005406)1.77003320
117Lactic acidosis (HP:0003128)1.76737752
118Reduced subcutaneous adipose tissue (HP:0003758)1.76638500
119Flat capital femoral epiphysis (HP:0003370)1.75753493
120Elbow flexion contracture (HP:0002987)1.75705965
121Genu recurvatum (HP:0002816)1.75175338
122Cerebral hemorrhage (HP:0001342)1.74974651
123Hepatic necrosis (HP:0002605)1.74876856
124Lipoatrophy (HP:0100578)1.74384843
125Increased connective tissue (HP:0009025)1.74098241
126Biconcave vertebral bodies (HP:0004586)1.73709407
127Abnormal platelet volume (HP:0011876)1.73594716
128Hyperparathyroidism (HP:0000843)1.73548043
129Hyperphosphaturia (HP:0003109)1.72449224
130Spinal cord compression (HP:0002176)1.71919315
131Ileus (HP:0002595)1.71875055
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71441597
133Aneurysm (HP:0002617)1.71123817
134Facial diplegia (HP:0001349)1.69632905
135Vascular calcification (HP:0004934)1.68664047
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67660592
137Abnormality of polysaccharide metabolism (HP:0011012)1.67660592
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67660592
139Amyloidosis (HP:0011034)1.67616178
140Distal lower limb muscle weakness (HP:0009053)1.66482011
141Abnormal albumin level (HP:0012116)1.66360080
142Hypoalbuminemia (HP:0003073)1.66360080
143Zonular cataract (HP:0010920)1.64151319
144Spondylolisthesis (HP:0003302)1.63990880
145Aortic valve stenosis (HP:0001650)1.63698874
146Vertebral hypoplasia (HP:0008417)1.63104168
147Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63104168
148Abnormal trabecular bone morphology (HP:0100671)1.62489148
149Neurofibrillary tangles (HP:0002185)1.61505696
150Respiratory difficulties (HP:0002880)1.60720319
151Growth hormone excess (HP:0000845)1.60106485
152Osteoarthritis (HP:0002758)1.59372663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.46126629
2NME23.98180714
3VRK23.39402586
4TESK13.36959551
5LIMK12.93923293
6MST42.89849645
7TTN2.64716708
8KDR2.63801630
9PIM22.51446352
10MAP3K122.39276187
11LRRK22.33833210
12EPHB22.10536204
13ILK2.08050289
14ARAF2.08017410
15MST1R1.87904332
16TIE11.83005560
17STK161.79493406
18DAPK31.65273319
19PIK3CA1.63857543
20TESK21.60955462
21PAK41.59861788
22PAK21.49373195
23NTRK11.44876981
24MAP2K71.43703343
25PTK2B1.41430697
26TRPM71.40811020
27DDR21.39996846
28EPHA21.35140776
29TBK11.31674699
30TRIB31.30063200
31PIK3CG1.28638813
32MAPK151.27290069
33BCKDK1.27281417
34LMTK21.27025209
35PBK1.26220448
36VRK11.23894774
37GRK71.22736932
38NME11.22528660
39MET1.18864012
40TGFBR21.18693190
41ERN11.16978813
42PRKG21.16784458
43DYRK21.13367331
44MAP2K21.12165559
45MAPKAPK31.08980938
46RPS6KB21.07305800
47TGFBR11.07285134
48MAP2K11.03913040
49ABL21.03724954
50BLK1.00979751
51CSNK1G30.96240472
52PAK10.94874227
53CSNK1G20.94113512
54BCR0.93226260
55MOS0.92822419
56PTK20.92228900
57PDK20.91400963
58EPHB10.91079472
59MAP3K30.90330677
60ROCK10.89010012
61STK390.87958486
62DMPK0.83631935
63DAPK10.83373915
64MAP3K20.81707015
65WNK40.81002539
66FER0.79755424
67OBSCN0.79319656
68ERBB40.78738984
69NUAK10.76528499
70ZAP700.75414863
71STK240.75103161
72PAK30.74011342
73ROCK20.73689159
74EPHA30.72016588
75JAK30.70582370
76CSNK1A1L0.68728104
77TLK10.68581126
78MAP2K30.68001653
79FRK0.67829051
80PDGFRA0.67417688
81RIPK40.67210330
82KIT0.66542283
83BMX0.66204272
84CSNK1G10.66020957
85KSR20.65540825
86IKBKB0.65489926
87MAP3K140.65123114
88MUSK0.64183752
89TEC0.64090945
90TYK20.63374788
91ZAK0.62377583
92ADRBK20.60929428
93NEK90.59275541
94RAF10.59058538
95RPS6KA40.56689133
96MAPKAPK20.56489979
97MAPKAPK50.55770115
98STK100.55410896
99PTK60.54430364
100MAP3K110.53204055
101MINK10.53005496
102FGR0.52995589
103CDK140.49343717
104IKBKE0.49044069
105GRK50.46964704
106TNIK0.46679210
107CASK0.45818491
108ITK0.45565426
109CSK0.45204747
110INSR0.44936767
111BMPR1B0.43682273
112AURKA0.42709679
113MARK10.42691118
114BUB10.42214489
115CDK180.39709792
116RIPK10.39490551
117MAP3K60.37899367
118CDK150.37483909
119SRPK10.37017797
120CAMK2D0.36919637
121CDK80.36584951
122STK38L0.36079674
123ADRBK10.35724675
124EGFR0.35459278
125ERBB30.35384562
126DYRK30.35176927
127SCYL20.34378703
128GSK3A0.34313951
129CAMK2G0.34247573
130CDK11A0.33356763
131GRK60.33231466
132LCK0.31923522
133MAP4K10.31639352
134MATK0.31582073
135IGF1R0.31310601
136SRC0.31196392
137PRKD10.30907919
138GRK10.30675172
139FLT30.30622923
140MAP3K80.30498668
141MAP3K50.30298813
142PRKCE0.29659497
143PRKCD0.27366899
144IRAK30.27116894
145LATS20.26331661
146DYRK1B0.20377928

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38883745
2Oxidative phosphorylation_Homo sapiens_hsa001904.05812633
3Parkinsons disease_Homo sapiens_hsa050123.42956904
4Proteasome_Homo sapiens_hsa030503.42858254
5Alzheimers disease_Homo sapiens_hsa050102.68805442
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.55463409
7Huntingtons disease_Homo sapiens_hsa050162.26033373
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.14857353
9Protein export_Homo sapiens_hsa030602.05888755
10Fatty acid elongation_Homo sapiens_hsa000622.00847470
11ECM-receptor interaction_Homo sapiens_hsa045121.88640324
12Cardiac muscle contraction_Homo sapiens_hsa042601.71112406
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.71065740
14Rheumatoid arthritis_Homo sapiens_hsa053231.70246356
15Focal adhesion_Homo sapiens_hsa045101.59568980
16Vibrio cholerae infection_Homo sapiens_hsa051101.59462168
17Graft-versus-host disease_Homo sapiens_hsa053321.57288567
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56288099
19Malaria_Homo sapiens_hsa051441.54249835
20Shigellosis_Homo sapiens_hsa051311.52127561
21Phagosome_Homo sapiens_hsa041451.45243358
22Leishmaniasis_Homo sapiens_hsa051401.41117877
23Salmonella infection_Homo sapiens_hsa051321.40660727
24Sulfur relay system_Homo sapiens_hsa041221.38004668
25Folate biosynthesis_Homo sapiens_hsa007901.35088654
26Pertussis_Homo sapiens_hsa051331.34045207
27Galactose metabolism_Homo sapiens_hsa000521.32020209
28Collecting duct acid secretion_Homo sapiens_hsa049661.29924752
29Allograft rejection_Homo sapiens_hsa053301.28061460
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25619985
31Amoebiasis_Homo sapiens_hsa051461.19799573
32Autoimmune thyroid disease_Homo sapiens_hsa053201.17656260
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11757733
34Proteoglycans in cancer_Homo sapiens_hsa052051.07171321
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06749524
36Lysosome_Homo sapiens_hsa041421.05583907
37Viral myocarditis_Homo sapiens_hsa054161.04472717
38Tight junction_Homo sapiens_hsa045301.02739680
39Platelet activation_Homo sapiens_hsa046110.99043432
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98687089
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98361459
42Sulfur metabolism_Homo sapiens_hsa009200.97781362
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97302506
44Toxoplasmosis_Homo sapiens_hsa051450.94799885
45Bladder cancer_Homo sapiens_hsa052190.94607534
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93841173
47Adherens junction_Homo sapiens_hsa045200.93765256
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93573629
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91214415
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90499971
51Dilated cardiomyopathy_Homo sapiens_hsa054140.90111884
52Apoptosis_Homo sapiens_hsa042100.89108893
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88787308
54Hematopoietic cell lineage_Homo sapiens_hsa046400.88237615
55Legionellosis_Homo sapiens_hsa051340.87468646
56Antigen processing and presentation_Homo sapiens_hsa046120.87332725
57Steroid biosynthesis_Homo sapiens_hsa001000.86972296
58Fructose and mannose metabolism_Homo sapiens_hsa000510.86499699
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85237152
60Tuberculosis_Homo sapiens_hsa051520.82180170
61Glutathione metabolism_Homo sapiens_hsa004800.80582396
62Other glycan degradation_Homo sapiens_hsa005110.80346177
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.79676659
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79440595
65Asthma_Homo sapiens_hsa053100.78100557
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77801809
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76540157
68HIF-1 signaling pathway_Homo sapiens_hsa040660.74507869
69N-Glycan biosynthesis_Homo sapiens_hsa005100.73762996
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72384891
71Small cell lung cancer_Homo sapiens_hsa052220.71879170
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71032019
73Mineral absorption_Homo sapiens_hsa049780.70515449
74Osteoclast differentiation_Homo sapiens_hsa043800.69344371
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69152654
76Arachidonic acid metabolism_Homo sapiens_hsa005900.68888442
77Protein digestion and absorption_Homo sapiens_hsa049740.68276767
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66518607
79TNF signaling pathway_Homo sapiens_hsa046680.65652301
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.64833865
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.62949470
82Synaptic vesicle cycle_Homo sapiens_hsa047210.62625425
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62184448
84TGF-beta signaling pathway_Homo sapiens_hsa043500.61499166
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61324364
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60214552
87* Vascular smooth muscle contraction_Homo sapiens_hsa042700.59936385
88Pyrimidine metabolism_Homo sapiens_hsa002400.59778372
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58607084
90Chemical carcinogenesis_Homo sapiens_hsa052040.58324450
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58104110
92Pyruvate metabolism_Homo sapiens_hsa006200.57232325
93Metabolic pathways_Homo sapiens_hsa011000.56950412
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56203767
95Endocytosis_Homo sapiens_hsa041440.55642262
96Peroxisome_Homo sapiens_hsa041460.55142402
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54990214
98Pentose phosphate pathway_Homo sapiens_hsa000300.54920838
99VEGF signaling pathway_Homo sapiens_hsa043700.53584134
100Basal cell carcinoma_Homo sapiens_hsa052170.53579190
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53445060
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53413487
103RNA polymerase_Homo sapiens_hsa030200.53003431
104Measles_Homo sapiens_hsa051620.50795360
105Renin-angiotensin system_Homo sapiens_hsa046140.50372827
106Hedgehog signaling pathway_Homo sapiens_hsa043400.49577098
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48091152
108Rap1 signaling pathway_Homo sapiens_hsa040150.48090440
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47450718
110Carbon metabolism_Homo sapiens_hsa012000.47252713
111African trypanosomiasis_Homo sapiens_hsa051430.46438372
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46018800
113Axon guidance_Homo sapiens_hsa043600.45867709
114Prion diseases_Homo sapiens_hsa050200.43721281
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42426480
116Sphingolipid metabolism_Homo sapiens_hsa006000.42120018
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42007428
118Pathways in cancer_Homo sapiens_hsa052000.41756366
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39414185
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38935062
121Chemokine signaling pathway_Homo sapiens_hsa040620.38152284
122Biosynthesis of amino acids_Homo sapiens_hsa012300.37881822
123PPAR signaling pathway_Homo sapiens_hsa033200.37647094
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.37253467
125Renal cell carcinoma_Homo sapiens_hsa052110.36523467
126Hippo signaling pathway_Homo sapiens_hsa043900.36498270
127Hepatitis B_Homo sapiens_hsa051610.36047633
128Tyrosine metabolism_Homo sapiens_hsa003500.35585839
129Hepatitis C_Homo sapiens_hsa051600.35291893
130Melanoma_Homo sapiens_hsa052180.35081143
131Thyroid cancer_Homo sapiens_hsa052160.34037761
132Epstein-Barr virus infection_Homo sapiens_hsa051690.33405690
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.33015276
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30803827
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30382179
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26753491
137Tryptophan metabolism_Homo sapiens_hsa003800.24741567
138Gap junction_Homo sapiens_hsa045400.23910859
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21195632
140Phenylalanine metabolism_Homo sapiens_hsa003600.21020574
141Purine metabolism_Homo sapiens_hsa002300.18860573

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