MYL6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle fiber development (GO:0048741)9.44840219
2* actin-mediated cell contraction (GO:0070252)8.84671694
3myotube cell development (GO:0014904)7.94258253
4positive regulation of myotube differentiation (GO:0010831)6.98898957
5regulation of skeletal muscle contraction (GO:0014819)6.96875046
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.83415689
7sarcoplasmic reticulum calcium ion transport (GO:0070296)6.80606789
8* actin filament-based movement (GO:0030048)6.63596200
9myoblast fusion (GO:0007520)6.26877845
10striated muscle contraction (GO:0006941)5.61972514
11syncytium formation by plasma membrane fusion (GO:0000768)5.59379709
12response to inactivity (GO:0014854)5.57074007
13muscle fiber development (GO:0048747)5.34697990
14muscle cell cellular homeostasis (GO:0046716)5.34631040
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.33361341
16muscle cell fate commitment (GO:0042693)5.31296539
17negative regulation of cell size (GO:0045792)5.29167349
18syncytium formation (GO:0006949)5.28740522
19sarcomere organization (GO:0045214)5.08433082
20sequestering of actin monomers (GO:0042989)5.01032126
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.80292206
22multicellular organismal movement (GO:0050879)4.60129014
23musculoskeletal movement (GO:0050881)4.60129014
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.59347576
25ATP synthesis coupled proton transport (GO:0015986)4.59347576
26* muscle contraction (GO:0006936)4.54032629
27positive regulation of myoblast differentiation (GO:0045663)4.45149660
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.37701231
29regulation of skeletal muscle cell differentiation (GO:2001014)4.29097576
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.25799349
31viral transcription (GO:0019083)4.20968451
32positive regulation of skeletal muscle tissue development (GO:0048643)4.20398395
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.20199019
34muscle organ development (GO:0007517)4.14541876
35establishment of protein localization to mitochondrial membrane (GO:0090151)4.10690287
36striated muscle atrophy (GO:0014891)4.09390373
37translational termination (GO:0006415)4.06231336
38chaperone-mediated protein transport (GO:0072321)4.01059269
39regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.99710374
40muscle structure development (GO:0061061)3.97752434
41* muscle system process (GO:0003012)3.94071840
42respiratory electron transport chain (GO:0022904)3.91880494
43myotube differentiation (GO:0014902)3.87052206
44behavioral response to nicotine (GO:0035095)3.86876389
45striated muscle cell development (GO:0055002)3.86688162
46electron transport chain (GO:0022900)3.83985515
47* skeletal muscle tissue development (GO:0007519)3.82148592
48neuromuscular synaptic transmission (GO:0007274)3.82018952
49synaptic vesicle maturation (GO:0016188)3.78732607
50ribosomal small subunit assembly (GO:0000028)3.78448338
51negative regulation of organelle assembly (GO:1902116)3.68720426
52ribosomal small subunit biogenesis (GO:0042274)3.66843545
53actomyosin structure organization (GO:0031032)3.64796202
54protein complex biogenesis (GO:0070271)3.63102378
55cytidine deamination (GO:0009972)3.61195052
56cytidine metabolic process (GO:0046087)3.61195052
57cytidine catabolic process (GO:0006216)3.61195052
58response to muscle activity (GO:0014850)3.60762878
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57946802
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.57946802
61NADH dehydrogenase complex assembly (GO:0010257)3.57946802
62regulation of cell communication by electrical coupling (GO:0010649)3.57250846
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54718515
64pyrimidine ribonucleoside catabolic process (GO:0046133)3.54010346
65cotranslational protein targeting to membrane (GO:0006613)3.52025982
66translational elongation (GO:0006414)3.51375891
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49599598
68protein targeting to ER (GO:0045047)3.48413895
69postsynaptic membrane organization (GO:0001941)3.45968476
70negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.44513193
71plasma membrane fusion (GO:0045026)3.39966184
72positive regulation of lamellipodium assembly (GO:0010592)3.38993325
73neuromuscular junction development (GO:0007528)3.35887355
74muscle cell development (GO:0055001)3.35559928
75establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33855155
76mitochondrial respiratory chain complex assembly (GO:0033108)3.31783990
77myofibril assembly (GO:0030239)3.31658903
78protein neddylation (GO:0045116)3.30650445
79barbed-end actin filament capping (GO:0051016)3.30478819
80protein localization to endoplasmic reticulum (GO:0070972)3.30197844
81regulation of myotube differentiation (GO:0010830)3.27162955
82regulation of synapse structural plasticity (GO:0051823)3.27065310
83muscle atrophy (GO:0014889)3.26181155
84maturation of SSU-rRNA (GO:0030490)3.23197416
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.18832752
86cellular protein complex disassembly (GO:0043624)3.17231499
87striated muscle adaptation (GO:0014888)3.14289523
88mRNA transcription from RNA polymerase II promoter (GO:0042789)3.13685845
89negative regulation of cardiac muscle tissue growth (GO:0055022)3.11441593
90negative regulation of heart growth (GO:0061117)3.11441593
91regulation of sarcomere organization (GO:0060297)3.11317137
92peptidyl-arginine omega-N-methylation (GO:0035247)3.10064304
93cardiac muscle contraction (GO:0060048)3.09257600
94positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.08802155
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.07514569
96viral life cycle (GO:0019058)3.06851989
97regulation of calcium ion transmembrane transport (GO:1903169)3.01097144
98regulation of calcium ion transmembrane transporter activity (GO:1901019)3.01097144
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99364934
100skeletal muscle adaptation (GO:0043501)2.94010667
101pyrimidine nucleobase catabolic process (GO:0006208)2.93753645
102regulation of potassium ion transmembrane transporter activity (GO:1901016)2.90482695
103membrane tubulation (GO:0097320)2.88315254
104ATP biosynthetic process (GO:0006754)2.88026805
105translational initiation (GO:0006413)2.87103378
106regulation of myoblast differentiation (GO:0045661)2.85721565
107mRNA transcription (GO:0009299)2.82516735
108protein complex disassembly (GO:0043241)2.81790769
109skeletal muscle tissue regeneration (GO:0043403)2.81722294
110peptidyl-arginine methylation (GO:0018216)2.80836785
111peptidyl-arginine N-methylation (GO:0035246)2.80836785
112regulation of relaxation of muscle (GO:1901077)2.79295300
113response to parathyroid hormone (GO:0071107)2.78237420
114regulation of translational termination (GO:0006449)2.78122826
115response to lithium ion (GO:0010226)2.76988518
116purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74513326
117cardiac myofibril assembly (GO:0055003)2.74270967
118regulation of membrane repolarization (GO:0060306)2.72113160
119purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71251009
120cellular response to estradiol stimulus (GO:0071392)2.71118895
121macromolecular complex disassembly (GO:0032984)2.71001598
122regulation of protein heterodimerization activity (GO:0043497)2.70912719
123positive regulation of striated muscle cell differentiation (GO:0051155)2.69304109
124negative regulation of potassium ion transport (GO:0043267)2.69060972
125positive regulation of muscle cell differentiation (GO:0051149)2.69012381
126tricarboxylic acid cycle (GO:0006099)2.68150466
127synaptic transmission, cholinergic (GO:0007271)2.65859651
128positive regulation of lamellipodium organization (GO:1902745)2.65273586
129inner mitochondrial membrane organization (GO:0007007)2.64812210
130hydrogen ion transmembrane transport (GO:1902600)2.64614416
131neuronal action potential propagation (GO:0019227)2.63498110
132regulation of striated muscle contraction (GO:0006942)2.61217421
133translation (GO:0006412)2.58449773
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57629967
135* actin filament-based process (GO:0030029)2.56545087
136negative regulation of protein localization to cell surface (GO:2000009)2.54888144
137oxidative phosphorylation (GO:0006119)2.53809184
138ribosomal large subunit biogenesis (GO:0042273)2.53294730
139regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52191546
140establishment of protein localization to mitochondrion (GO:0072655)2.50789233
141protein targeting to mitochondrion (GO:0006626)2.50485381
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48679346
143ubiquinone biosynthetic process (GO:0006744)2.47879765
144ribonucleoside triphosphate biosynthetic process (GO:0009201)2.47589319
145protein targeting to membrane (GO:0006612)2.47574123
146mitochondrial fusion (GO:0008053)2.46864176
147regulation of p38MAPK cascade (GO:1900744)2.44874396
148respiratory chain complex IV assembly (GO:0008535)2.42840390
149regulation of skeletal muscle fiber development (GO:0048742)2.42762900
150intracellular protein transmembrane import (GO:0044743)2.41949295
151regulation of cellular respiration (GO:0043457)2.40863916
152ubiquinone metabolic process (GO:0006743)2.40224788
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.38667942
154purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.38510458
155purine nucleoside monophosphate biosynthetic process (GO:0009127)2.38510458
156regulation of mitochondrial translation (GO:0070129)2.38304064
157otic vesicle formation (GO:0030916)2.38137534
158nucleoside triphosphate biosynthetic process (GO:0009142)2.34871939
159proton transport (GO:0015992)2.34438896
160termination of RNA polymerase III transcription (GO:0006386)2.33433205
161transcription elongation from RNA polymerase III promoter (GO:0006385)2.33433205
162protein localization to mitochondrion (GO:0070585)2.32750474
163GTP biosynthetic process (GO:0006183)2.31720642
164regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.30609705
165hydrogen transport (GO:0006818)2.30193365
166somite development (GO:0061053)2.28257723
167DNA damage response, detection of DNA damage (GO:0042769)2.28232603
168* muscle filament sliding (GO:0030049)11.3494276
169* actin-myosin filament sliding (GO:0033275)11.3494276
170skeletal muscle contraction (GO:0003009)10.7250930
171plasma membrane repair (GO:0001778)10.3450393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61353608
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.32537517
3* ZFP281_18757296_ChIP-ChIP_E14_Mouse3.06635681
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99954575
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.90962068
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.75452031
7* MYC_22102868_ChIP-Seq_BL_Human2.74953916
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72718737
9LXR_22292898_ChIP-Seq_THP-1_Human2.59036624
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.51905610
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36059689
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33213844
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32316771
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28207597
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.26106027
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24715119
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22311925
18KDM2B_26808549_Chip-Seq_DND41_Human2.20363495
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.19817715
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19759609
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18567373
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17254088
23VDR_21846776_ChIP-Seq_THP-1_Human2.15332086
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13048121
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10860600
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.09362797
27* TCF7_22412390_ChIP-Seq_EML_Mouse2.07573763
28ZNF263_19887448_ChIP-Seq_K562_Human2.06808565
29* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04529592
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.04099890
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01316175
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00071155
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.99314096
34* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90178062
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86980593
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82413336
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.81940125
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.81534696
39CTCF_21964334_ChIP-Seq_BJAB-B_Human1.78810056
40CTCF_21964334_Chip-Seq_Bcells_Human1.77738284
41ZNF274_21170338_ChIP-Seq_K562_Hela1.76344295
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75552784
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74973472
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74341621
45UTX_26944678_Chip-Seq_JUKART_Human1.74057108
46MAF_26560356_Chip-Seq_TH1_Human1.72086897
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71037461
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68723636
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67950359
50* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67619810
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.67315990
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66703929
53* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66559846
54IGF1R_20145208_ChIP-Seq_DFB_Human1.63830960
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62594332
56TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.62145258
57VDR_22108803_ChIP-Seq_LS180_Human1.61257691
58RACK7_27058665_Chip-Seq_MCF-7_Human1.60745090
59ATF3_27146783_Chip-Seq_COLON_Human1.60736558
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58207093
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.57901215
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57362442
63TP53_22127205_ChIP-Seq_IMR90_Human1.57087230
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56934666
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56076706
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54652211
67BCL6_27268052_Chip-Seq_Bcells_Human1.54651716
68GBX2_23144817_ChIP-Seq_PC3_Human1.53651137
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52503038
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51995159
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.51608359
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51140966
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50938005
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.49021916
75* XRN2_22483619_ChIP-Seq_HELA_Human1.48980100
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47952334
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.47437007
78SA1_27219007_Chip-Seq_Bcells_Human1.46830306
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.46686304
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.46536808
81REST_21632747_ChIP-Seq_MESCs_Mouse1.45515204
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.44212503
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.43521522
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43083841
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42925125
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40186453
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40186265
88* P68_20966046_ChIP-Seq_HELA_Human1.40072130
89MAF_26560356_Chip-Seq_TH2_Human1.39516169
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39500979
91KDM2B_26808549_Chip-Seq_K562_Human1.38796103
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.37079513
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36887346
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36887346
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36610233
96MYC_18940864_ChIP-ChIP_HL60_Human1.35588882
97FUS_26573619_Chip-Seq_HEK293_Human1.34488122
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34037393
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33546308
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33087181
101CTCF_26484167_Chip-Seq_Bcells_Mouse1.32318284
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.31794702
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31496402
104SPI1_23127762_ChIP-Seq_K562_Human1.31264227
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30035108
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30027834
107* SA1_27219007_Chip-Seq_ERYTHROID_Human1.28480601
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28396729
109TTF2_22483619_ChIP-Seq_HELA_Human1.27602164
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25771027
111SMC4_20622854_ChIP-Seq_HELA_Human1.23906024
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23857190
113RNF2_27304074_Chip-Seq_NSC_Mouse1.23785953
114SCL_19346495_ChIP-Seq_HPC-7_Human1.22469817
115SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.22343537
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21007283
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20404621
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20108486
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20091759
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20017000
121TBX20_22080862_ChIP-Seq_HEART_Mouse1.19100271
122TBX20_22328084_ChIP-Seq_HEART_Mouse1.19100271
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19045391
124CTCF_27219007_Chip-Seq_Bcells_Human1.18793141
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.18113914
126SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17417302
127* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16103735
128TP53_20018659_ChIP-ChIP_R1E_Mouse1.16014961
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15954960
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.15813302
131* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15341134
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15159963
133* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13341241
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12969398
135CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11285689
136CREB1_26743006_Chip-Seq_LNCaP_Human1.10746444
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10031352
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09559395
139SOX2_16153702_ChIP-ChIP_HESCs_Human1.09482778
140STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09328692
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08590556
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08212931
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07841181
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07821631
145CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07432416
146TP53_23651856_ChIP-Seq_MEFs_Mouse1.06942901
147* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06680586
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06487276
149MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06327112
150CIITA_25753668_ChIP-Seq_RAJI_Human1.06283999
151VDR_24763502_ChIP-Seq_THP-1_Human1.05658564
152SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04504041
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04483613
154GATA1_22025678_ChIP-Seq_K562_Human1.04315933
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03584527
156SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03531371
157* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03496670
158STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03240443
159ELK1_19687146_ChIP-ChIP_HELA_Human1.02660528
160ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02446530
161SPI1_20517297_ChIP-Seq_HL60_Human1.02244672
162KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01612570
163KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01490782
164GABP_19822575_ChIP-Seq_HepG2_Human1.01478340
165DROSHA_22980978_ChIP-Seq_HELA_Human1.01365372
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01001894
167IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00814657
168* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00565241
169* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00022880
170* RUNX1_22412390_ChIP-Seq_EML_Mouse0.99223490
171FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98554300
172YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98233189
173FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97947681
174OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97374268
175MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95853435
176E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95653973
177RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95436783
178SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94612058
179MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93382885
180MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92909695
181* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92659296
182SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91124422
183VDR_23849224_ChIP-Seq_CD4+_Human0.89807052
184SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88419378
185* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88255503
186CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85845363
187TP53_22573176_ChIP-Seq_HFKS_Human0.84397725
188KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83574415
189MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83228288
190P300_19829295_ChIP-Seq_ESCs_Human0.81932503
191RING1B_27294783_Chip-Seq_ESCs_Mouse0.81914746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration6.49440227
2MP0000751_myopathy6.30927540
3MP0004145_abnormal_muscle_electrophysio5.23417653
4MP0000747_muscle_weakness4.39568719
5MP0000750_abnormal_muscle_regeneration4.13023505
6MP0000733_abnormal_muscle_development3.92019396
7MP0004270_analgesia3.84588790
8MP0002106_abnormal_muscle_physiology3.74443145
9MP0000759_abnormal_skeletal_muscle3.71982368
10MP0004087_abnormal_muscle_fiber3.43198921
11MP0002269_muscular_atrophy3.19923854
12MP0005369_muscle_phenotype3.11707733
13MP0004233_abnormal_muscle_weight2.84440356
14MP0003950_abnormal_plasma_membrane2.73547426
15MP0002837_dystrophic_cardiac_calcinosis2.71326808
16MP0009379_abnormal_foot_pigmentation2.25812473
17MP0003646_muscle_fatigue2.24736124
18MP0004036_abnormal_muscle_relaxation2.16445011
19MP0002108_abnormal_muscle_morphology2.09425345
20MP0004859_abnormal_synaptic_plasticity2.08620530
21MP0004084_abnormal_cardiac_muscle2.06395097
22MP0003880_abnormal_central_pattern2.02820655
23MP0001529_abnormal_vocalization2.00737286
24MP0005330_cardiomyopathy1.99065744
25MP0005620_abnormal_muscle_contractility1.93906622
26MP0006292_abnormal_olfactory_placode1.92928107
27MP0008438_abnormal_cutaneous_collagen1.90308977
28MP0002822_catalepsy1.72124895
29MP0003122_maternal_imprinting1.69749073
30MP0004130_abnormal_muscle_cell1.69064361
31MP0005623_abnormal_meninges_morphology1.68846965
32MP0003123_paternal_imprinting1.67232086
33MP0009780_abnormal_chondrocyte_physiolo1.63057654
34MP0006276_abnormal_autonomic_nervous1.62531979
35MP0003136_yellow_coat_color1.57332493
36MP0008789_abnormal_olfactory_epithelium1.53303824
37MP0004142_abnormal_muscle_tone1.45755662
38MP0004215_abnormal_myocardial_fiber1.45721599
39MP0002971_abnormal_brown_adipose1.41386810
40MP0001984_abnormal_olfaction1.38151812
41MP0002938_white_spotting1.37971251
42MP0002272_abnormal_nervous_system1.35691085
43MP0003121_genomic_imprinting1.34589738
44MP0006072_abnormal_retinal_apoptosis1.34318164
45MP0005394_taste/olfaction_phenotype1.33263707
46MP0005499_abnormal_olfactory_system1.33263707
47MP0000778_abnormal_nervous_system1.31851487
48MP0008961_abnormal_basal_metabolism1.26184429
49MP0005503_abnormal_tendon_morphology1.24887976
50MP0002736_abnormal_nociception_after1.24069353
51MP0001968_abnormal_touch/_nociception1.23327162
52MP0000049_abnormal_middle_ear1.21848299
53MP0010630_abnormal_cardiac_muscle1.20690146
54MP0003011_delayed_dark_adaptation1.19895883
55MP0000372_irregular_coat_pigmentation1.18489303
56MP0000013_abnormal_adipose_tissue1.18373166
57MP0002638_abnormal_pupillary_reflex1.15593844
58MP0001905_abnormal_dopamine_level1.15558254
59MP0003879_abnormal_hair_cell1.15058284
60MP0002102_abnormal_ear_morphology1.13649311
61MP0003787_abnormal_imprinting1.13450360
62MP0008569_lethality_at_weaning1.12801326
63MP0002163_abnormal_gland_morphology1.11666387
64MP0002734_abnormal_mechanical_nocicepti1.11199529
65MP0003635_abnormal_synaptic_transmissio1.10908128
66MP0002653_abnormal_ependyma_morphology1.08609767
67MP0002572_abnormal_emotion/affect_behav1.06721710
68MP0001486_abnormal_startle_reflex1.04708564
69MP0000631_abnormal_neuroendocrine_gland1.04192237
70MP0003315_abnormal_perineum_morphology1.01541837
71MP0003283_abnormal_digestive_organ1.01066727
72MP0002972_abnormal_cardiac_muscle1.00335018
73MP0002909_abnormal_adrenal_gland1.00324045
74MP0004133_heterotaxia1.00200073
75MP0002752_abnormal_somatic_nervous0.99430178
76MP0004484_altered_response_of0.99003838
77MP0001542_abnormal_bone_strength0.97829591
78MP0005646_abnormal_pituitary_gland0.96181987
79MP0002067_abnormal_sensory_capabilities0.95902215
80MP0004510_myositis0.94860179
81MP0001293_anophthalmia0.94779702
82MP0009250_abnormal_appendicular_skeleto0.94613318
83MP0002234_abnormal_pharynx_morphology0.92481672
84MP0002557_abnormal_social/conspecific_i0.91849214
85MP0005253_abnormal_eye_physiology0.90696766
86MP0001970_abnormal_pain_threshold0.90137136
87MP0003385_abnormal_body_wall0.88578773
88MP0003329_amyloid_beta_deposits0.88357395
89MP0001485_abnormal_pinna_reflex0.88115462
90MP0002882_abnormal_neuron_morphology0.86838231
91MP0005551_abnormal_eye_electrophysiolog0.86417735
92MP0003137_abnormal_impulse_conducting0.85799744
93MP0001188_hyperpigmentation0.85746516
94MP0001346_abnormal_lacrimal_gland0.85633225
95MP0000566_synostosis0.85573227
96MP0002735_abnormal_chemical_nociception0.83933666
97MP0002733_abnormal_thermal_nociception0.83866263
98MP0005275_abnormal_skin_tensile0.83778122
99MP0005187_abnormal_penis_morphology0.83676931
100MP0003705_abnormal_hypodermis_morpholog0.83648076
101MP0003942_abnormal_urinary_system0.82360467
102MP0001348_abnormal_lacrimal_gland0.81868093
103MP0002233_abnormal_nose_morphology0.81481485
104MP0003938_abnormal_ear_development0.80123361
105MP0002114_abnormal_axial_skeleton0.79632744
106MP0000026_abnormal_inner_ear0.79456814
107MP0006036_abnormal_mitochondrial_physio0.78848431
108MP0003119_abnormal_digestive_system0.77896952
109MP0004147_increased_porphyrin_level0.77039467
110MP0003221_abnormal_cardiomyocyte_apopto0.72810619
111MP0005076_abnormal_cell_differentiation0.71815710
112MP0003279_aneurysm0.69582800
113MP0002089_abnormal_postnatal_growth/wei0.67922710
114MP0000858_altered_metastatic_potential0.66853188
115MP0008770_decreased_survivor_rate0.66488206
116MP0000955_abnormal_spinal_cord0.65932157
117MP0002396_abnormal_hematopoietic_system0.65527471
118MP0004858_abnormal_nervous_system0.65470479
119MP0001299_abnormal_eye_distance/0.62536607
120MP0004808_abnormal_hematopoietic_stem0.62531409
121MP0004811_abnormal_neuron_physiology0.60286555
122MP0002877_abnormal_melanocyte_morpholog0.60011247
123MP0000569_abnormal_digit_pigmentation0.58912338
124MP0010352_gastrointestinal_tract_polyps0.58677112
125MP0005423_abnormal_somatic_nervous0.57241215
126MP0000003_abnormal_adipose_tissue0.54440053
127MP0002063_abnormal_learning/memory/cond0.53888402
128MP0002184_abnormal_innervation0.53559655
129MP0002066_abnormal_motor_capabilities/c0.52981430
130MP0002249_abnormal_larynx_morphology0.52896709
131MP0001943_abnormal_respiration0.52240190
132MP0003566_abnormal_cell_adhesion0.51997824
133MP0003091_abnormal_cell_migration0.51728855
134MP0001544_abnormal_cardiovascular_syste0.51137174
135MP0005385_cardiovascular_system_phenoty0.51137174
136MP0001958_emphysema0.51002449
137MP0008007_abnormal_cellular_replicative0.50918817
138MP0005266_abnormal_metabolism0.48581123
139MP0002332_abnormal_exercise_endurance0.47504543
140MP0005375_adipose_tissue_phenotype0.47471362
141MP0005452_abnormal_adipose_tissue0.47038927
142MP0000358_abnormal_cell_content/0.46989357
143MP0010307_abnormal_tumor_latency0.46501958
144MP0006035_abnormal_mitochondrial_morpho0.45135613
145MP0001440_abnormal_grooming_behavior0.44226704
146MP0000266_abnormal_heart_morphology0.40783341
147MP0004197_abnormal_fetal_growth/weight/0.39989704
148MP0009745_abnormal_behavioral_response0.39418670
149MP0004134_abnormal_chest_morphology0.39129629
150MP0009046_muscle_twitch0.39108244
151MP0010030_abnormal_orbit_morphology0.39063434
152MP0002970_abnormal_white_adipose0.38769304
153MP0002064_seizures0.38742808
154MP0005058_abnormal_lysosome_morphology0.38477107
155MP0005367_renal/urinary_system_phenotyp0.37966247
156MP0000516_abnormal_urinary_system0.37966247
157MP0001915_intracranial_hemorrhage0.37655884
158MP0001730_embryonic_growth_arrest0.37049476
159MP0009672_abnormal_birth_weight0.36532539
160MP0002166_altered_tumor_susceptibility0.35645515

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.36998453
2Nemaline bodies (HP:0003798)9.29857999
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.21619999
4Type 1 muscle fiber predominance (HP:0003803)8.24320660
5Fetal akinesia sequence (HP:0001989)7.41202556
6Distal arthrogryposis (HP:0005684)7.01393679
7Round ear (HP:0100830)5.86919307
8Popliteal pterygium (HP:0009756)5.84453415
9Ulnar deviation of the wrist (HP:0003049)5.80883243
10Myopathic facies (HP:0002058)5.70477994
11Aplasia of the musculature (HP:0100854)5.31495592
12Malignant hyperthermia (HP:0002047)5.27997499
13Abnormality of placental membranes (HP:0011409)5.14987751
14Amniotic constriction ring (HP:0009775)5.14987751
15Calcaneovalgus deformity (HP:0001848)4.93706968
16Akinesia (HP:0002304)4.79343072
17Type 2 muscle fiber atrophy (HP:0003554)4.66970068
18Deformed tarsal bones (HP:0008119)4.46690415
19Muscle fiber atrophy (HP:0100295)4.29810163
20Abnormality of skeletal muscle fiber size (HP:0012084)4.15712287
21Difficulty running (HP:0009046)4.13247572
22Weak cry (HP:0001612)4.09933013
23Exercise-induced myalgia (HP:0003738)3.99221101
24Bulbar palsy (HP:0001283)3.95081021
25Fatigable weakness (HP:0003473)3.93803529
26Abnormality of the neuromuscular junction (HP:0003398)3.93803529
27Absent phalangeal crease (HP:0006109)3.84139455
28Calf muscle hypertrophy (HP:0008981)3.83852656
29EMG: myopathic abnormalities (HP:0003458)3.78723619
30Acute necrotizing encephalopathy (HP:0006965)3.68744960
31Muscle hypertrophy of the lower extremities (HP:0008968)3.65704341
32Abnormality of the calf musculature (HP:0001430)3.65460953
33Gowers sign (HP:0003391)3.62956669
34Muscle fiber splitting (HP:0003555)3.54237985
35Difficulty climbing stairs (HP:0003551)3.47551111
36Centrally nucleated skeletal muscle fibers (HP:0003687)3.46431728
37Hip contracture (HP:0003273)3.45172589
38Rimmed vacuoles (HP:0003805)3.42783364
39Abnormal mitochondria in muscle tissue (HP:0008316)3.38674828
40Neck muscle weakness (HP:0000467)3.38318727
41Slender build (HP:0001533)3.37185344
42Exercise-induced muscle cramps (HP:0003710)3.29313226
43Mildly elevated creatine phosphokinase (HP:0008180)3.27461054
44Increased variability in muscle fiber diameter (HP:0003557)3.26194308
45Hyporeflexia of lower limbs (HP:0002600)3.23524047
46Trismus (HP:0000211)3.22069338
47Thin ribs (HP:0000883)3.19792393
48Abnormal finger flexion creases (HP:0006143)3.16056012
49Mitochondrial inheritance (HP:0001427)3.14961597
50Aplasia/Hypoplasia involving the musculature (HP:0001460)3.14211645
51Acute encephalopathy (HP:0006846)3.13078232
52Abnormality of the calcaneus (HP:0008364)3.08834302
53Frequent falls (HP:0002359)3.08029542
54Progressive macrocephaly (HP:0004481)3.06321453
55Pterygium (HP:0001059)3.05885487
56Easy fatigability (HP:0003388)2.92312857
57Generalized muscle weakness (HP:0003324)2.82690700
58Increased connective tissue (HP:0009025)2.70865830
59Increased CSF lactate (HP:0002490)2.66183196
60Hepatocellular necrosis (HP:0001404)2.65929067
61Breech presentation (HP:0001623)2.61330701
62Cystic hygroma (HP:0000476)2.57551966
63Hypoplastic heart (HP:0001961)2.55950754
64Increased hepatocellular lipid droplets (HP:0006565)2.52259683
65Lipid accumulation in hepatocytes (HP:0006561)2.49766477
66Hepatic necrosis (HP:0002605)2.49639807
67Spinal rigidity (HP:0003306)2.44617353
68Long clavicles (HP:0000890)2.43096683
69EMG: neuropathic changes (HP:0003445)2.40177886
70Respiratory insufficiency due to muscle weakness (HP:0002747)2.38797311
71Myotonia (HP:0002486)2.37384724
72Scapular winging (HP:0003691)2.37337726
73Myokymia (HP:0002411)2.37248693
74Progressive muscle weakness (HP:0003323)2.36538029
75Webbed neck (HP:0000465)2.36146515
76Exercise intolerance (HP:0003546)2.36086374
77Increased intramyocellular lipid droplets (HP:0012240)2.35713150
78Rhabdomyolysis (HP:0003201)2.33481702
79Diminished movement (HP:0002374)2.33170305
80Limb-girdle muscle atrophy (HP:0003797)2.28278182
81Limited hip movement (HP:0008800)2.23880610
82Reticulocytopenia (HP:0001896)2.23053231
83Metatarsus adductus (HP:0001840)2.18551826
84Cerebral edema (HP:0002181)2.17478924
85Shoulder girdle muscle weakness (HP:0003547)2.15643649
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15184986
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15184986
88Facial diplegia (HP:0001349)2.14446904
89Abnormality of the musculature of the pelvis (HP:0001469)2.13381861
90Abnormality of the hip-girdle musculature (HP:0001445)2.13381861
91Pelvic girdle muscle weakness (HP:0003749)2.06515008
92Proximal amyotrophy (HP:0007126)2.06010237
93Renal Fanconi syndrome (HP:0001994)2.05362069
94Waddling gait (HP:0002515)2.05094951
95Arthrogryposis multiplex congenita (HP:0002804)2.04309741
96Abnormality of cells of the erythroid lineage (HP:0012130)2.03815588
97Increased muscle lipid content (HP:0009058)2.03629973
98Distal lower limb amyotrophy (HP:0008944)1.93243912
99Abnormal number of erythroid precursors (HP:0012131)1.92641714
100Symphalangism affecting the phalanges of the hand (HP:0009773)1.91430893
101Increased density of long bones (HP:0006392)1.90008216
102Abnormality of the shoulder girdle musculature (HP:0001435)1.88713960
103Mask-like facies (HP:0000298)1.88348668
104Lactic acidosis (HP:0003128)1.87463548
105Poor suck (HP:0002033)1.85904994
106Optic disc pallor (HP:0000543)1.84564638
107Abnormalities of placenta or umbilical cord (HP:0001194)1.83282966
108Congenital hip dislocation (HP:0001374)1.83203834
109Muscle stiffness (HP:0003552)1.81801740
110Rib fusion (HP:0000902)1.79531827
111Limb dystonia (HP:0002451)1.76947282
112Type II lissencephaly (HP:0007260)1.74908745
113Respiratory failure (HP:0002878)1.72459754
114Ulnar deviation of finger (HP:0009465)1.72418334
115Adducted thumb (HP:0001181)1.72007986
116Lower limb amyotrophy (HP:0007210)1.71910573
117Nonprogressive disorder (HP:0003680)1.71444491
118Myoglobinuria (HP:0002913)1.71316242
119Macrocytic anemia (HP:0001972)1.68896151
120Limb-girdle muscle weakness (HP:0003325)1.67572688
121Areflexia of lower limbs (HP:0002522)1.66398547
122Left ventricular hypertrophy (HP:0001712)1.64349706
123Abnormality of the left ventricular outflow tract (HP:0011103)1.64298321
124Subaortic stenosis (HP:0001682)1.64298321
125Sudden death (HP:0001699)1.63884357
126Increased serum lactate (HP:0002151)1.63264855
1273-Methylglutaconic aciduria (HP:0003535)1.62046585
128Focal motor seizures (HP:0011153)1.60881764
129Medial flaring of the eyebrow (HP:0010747)1.59665149
130Asymmetric septal hypertrophy (HP:0001670)1.59285954
131True hermaphroditism (HP:0010459)1.59134273
132Abnormality of the labia minora (HP:0012880)1.58196036
133Pancreatic fibrosis (HP:0100732)1.57629020
134Absent septum pellucidum (HP:0001331)1.57191886
135Abnormality of midbrain morphology (HP:0002418)1.55931060
136Neonatal respiratory distress (HP:0002643)1.50110879
137Distal upper limb amyotrophy (HP:0007149)1.48523323
138Upper limb amyotrophy (HP:0009129)1.48523323
139Distal lower limb muscle weakness (HP:0009053)1.47496170
140Muscular dystrophy (HP:0003560)1.44318351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.04043993
2PIK3CG4.79629583
3TRIB33.80788077
4MUSK3.70631944
5TTN3.00154506
6MOS2.89487195
7STK162.69719728
8VRK22.50230549
9PIM22.33520002
10LIMK12.18753527
11PDK32.12542352
12PDK42.12542352
13NEK12.10403981
14PKN22.03157038
15ZAK1.94592752
16DYRK21.91325580
17TESK21.77939645
18MAP3K101.70969528
19BCKDK1.66639121
20MARK11.62863429
21CASK1.53093122
22PHKG21.52722852
23PHKG11.52722852
24WNK31.52604679
25PAK41.47675800
26TESK11.47544460
27PAK61.40259129
28EEF2K1.39166925
29EPHA41.39013247
30MAP3K121.38063212
31ILK1.34130444
32VRK11.28521386
33MAP4K21.25968265
34EPHB21.25781090
35MAPK131.23019634
36BMPR1B1.22257658
37MAPKAPK31.21760306
38TLK11.18727666
39CDK191.18489355
40MAPK121.17192541
41SCYL21.12827362
42CDK151.11272983
43CDK141.11214192
44CSNK1G21.10763326
45MAP3K91.08862371
46CAMKK11.08585227
47LATS21.07711404
48PRKD31.07220991
49ICK1.07156807
50CDK181.06782383
51MAP3K71.05927917
52NME21.04636547
53CDK11A1.03868047
54CSNK1G31.01609753
55TNIK1.00884795
56PINK11.00275846
57KDR0.95775516
58PRKCG0.93256265
59CSNK1G10.91438513
60TYRO30.91176721
61PLK20.90469471
62PDK20.90267867
63ARAF0.89545200
64PKN10.86287769
65CCNB10.85411504
66MAP3K110.84413184
67DYRK1B0.84196367
68GRK10.84134116
69MAP2K60.83954449
70DMPK0.83881520
71TAOK10.83256992
72MAP2K10.81948068
73CDC70.79437100
74ADRBK20.78075451
75CSNK1A1L0.76004137
76AKT20.75716591
77ALK0.75189608
78DAPK20.75132181
79MINK10.74327470
80DYRK30.73432795
81MAP2K30.73012997
82LRRK20.72071848
83NME10.71799982
84TAOK20.71570165
85PLK30.71175425
86DAPK30.70795942
87MAP3K50.70048478
88MAP2K40.69643561
89DAPK10.68194081
90BRAF0.66300970
91WNK40.65725277
92SRPK10.64663590
93RIPK10.62036164
94KSR10.61250479
95STK380.61074471
96CAMK2A0.60613265
97ROCK20.60586573
98NTRK30.59186220
99CDK80.59086183
100FGFR20.58190640
101NEK20.57958412
102PLK40.57780525
103TIE10.57459493
104PBK0.56033836
105PLK10.55520280
106UHMK10.55398096
107CAMKK20.54926191
108AURKA0.54756799
109KSR20.54570276
110CDK60.52554335
111INSRR0.52109620
112MARK20.51997630
113MAP3K40.50642778
114ROCK10.50117151
115PRKACA0.49261921
116CDK50.48921513
117NUAK10.48081455
118PAK30.47670449
119BUB10.46915276
120PRKG10.46194386
121MAPK110.46126880
122WEE10.45806122
123PDGFRA0.44123754
124CAMK2D0.43917009
125ABL20.43371972
126AURKB0.43015070
127PDK10.42925052
128PNCK0.41964623
129SGK2230.41613337
130SGK4940.41613337
131CSNK2A20.41534736
132CAMK2B0.41287132
133TGFBR10.39217948
134PTK60.38800790
135ERBB30.38737859
136RAF10.38321488
137CSNK1E0.38301072
138MAP2K70.36943716
139MAPK40.34004548
140KIT0.33874530
141PDPK10.33657015
142MTOR0.33648695
143TNK20.32969716
144DDR20.32759001
145TRPM70.32472595
146PTK20.30412373
147NTRK10.29323856
148PAK10.29141578
149EPHB10.28881051
150ZAP700.28208145
151RPS6KA30.27559167
152BRSK10.25849441
153CAMK2G0.24679529
154CAMK10.24291806
155MAP4K10.23316879
156STK110.22827970
157ERN10.22542336
158NTRK20.21764811

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.20972810
2Ribosome_Homo sapiens_hsa030104.05554406
3Parkinsons disease_Homo sapiens_hsa050123.88642233
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.63583625
5Dilated cardiomyopathy_Homo sapiens_hsa054143.55265121
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.03121337
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95646805
8Alzheimers disease_Homo sapiens_hsa050102.83256305
9Cardiac muscle contraction_Homo sapiens_hsa042602.65526189
10Huntingtons disease_Homo sapiens_hsa050162.62236598
11RNA polymerase_Homo sapiens_hsa030202.10695530
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08549006
13Viral myocarditis_Homo sapiens_hsa054162.02249592
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.00651433
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00021918
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90612000
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76858026
18* Oxytocin signaling pathway_Homo sapiens_hsa049211.67550011
19Protein export_Homo sapiens_hsa030601.64337624
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62488507
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58968799
22Synaptic vesicle cycle_Homo sapiens_hsa047211.56856428
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53091450
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52480990
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51081424
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47638992
27Focal adhesion_Homo sapiens_hsa045101.43960681
28Insulin signaling pathway_Homo sapiens_hsa049101.41828165
29Propanoate metabolism_Homo sapiens_hsa006401.39701736
30Tight junction_Homo sapiens_hsa045301.36966011
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34868609
32Phototransduction_Homo sapiens_hsa047441.32810042
33Pyruvate metabolism_Homo sapiens_hsa006201.28256921
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23733179
35Glucagon signaling pathway_Homo sapiens_hsa049221.20619162
36Sulfur relay system_Homo sapiens_hsa041221.16472015
37Carbon metabolism_Homo sapiens_hsa012001.16129031
38Biosynthesis of amino acids_Homo sapiens_hsa012301.15595231
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14908858
40VEGF signaling pathway_Homo sapiens_hsa043701.14632228
41Butanoate metabolism_Homo sapiens_hsa006501.13872859
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13412369
43Arginine and proline metabolism_Homo sapiens_hsa003301.13074007
44Proteoglycans in cancer_Homo sapiens_hsa052051.10626340
45Purine metabolism_Homo sapiens_hsa002301.10170554
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.08326587
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06565947
48Mismatch repair_Homo sapiens_hsa034301.05712054
49Basal transcription factors_Homo sapiens_hsa030221.04597954
50Pyrimidine metabolism_Homo sapiens_hsa002401.04452119
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04039311
52Long-term potentiation_Homo sapiens_hsa047201.03567115
53mTOR signaling pathway_Homo sapiens_hsa041501.01286053
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01264863
55Glioma_Homo sapiens_hsa052141.01043057
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00298779
57Endocytosis_Homo sapiens_hsa041440.99696331
58RNA degradation_Homo sapiens_hsa030180.99541878
59Proteasome_Homo sapiens_hsa030500.99138005
60Nitrogen metabolism_Homo sapiens_hsa009100.98780566
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97424475
62Nucleotide excision repair_Homo sapiens_hsa034200.96181555
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95350385
64DNA replication_Homo sapiens_hsa030300.95243248
65GABAergic synapse_Homo sapiens_hsa047270.95116067
66Basal cell carcinoma_Homo sapiens_hsa052170.95040486
67Chronic myeloid leukemia_Homo sapiens_hsa052200.95039045
68Circadian entrainment_Homo sapiens_hsa047130.95001730
69Fatty acid elongation_Homo sapiens_hsa000620.94143689
70Oocyte meiosis_Homo sapiens_hsa041140.94058952
71Hedgehog signaling pathway_Homo sapiens_hsa043400.93755128
72Olfactory transduction_Homo sapiens_hsa047400.92217237
73MAPK signaling pathway_Homo sapiens_hsa040100.91281410
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90980968
75Base excision repair_Homo sapiens_hsa034100.90205339
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.88863046
77HIF-1 signaling pathway_Homo sapiens_hsa040660.88723247
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.88497101
79Platelet activation_Homo sapiens_hsa046110.87854135
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87829596
81Homologous recombination_Homo sapiens_hsa034400.87308016
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86935301
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86584006
84Salmonella infection_Homo sapiens_hsa051320.86551023
85AMPK signaling pathway_Homo sapiens_hsa041520.86373898
86Bladder cancer_Homo sapiens_hsa052190.85557196
87GnRH signaling pathway_Homo sapiens_hsa049120.83365162
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81650506
89Gap junction_Homo sapiens_hsa045400.81493805
90Gastric acid secretion_Homo sapiens_hsa049710.81200895
91Galactose metabolism_Homo sapiens_hsa000520.81097595
92Fanconi anemia pathway_Homo sapiens_hsa034600.81010465
93Colorectal cancer_Homo sapiens_hsa052100.79867123
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.78498227
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78382246
96Primary immunodeficiency_Homo sapiens_hsa053400.78013680
97Calcium signaling pathway_Homo sapiens_hsa040200.77251779
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76904782
99Shigellosis_Homo sapiens_hsa051310.76204572
100Pentose phosphate pathway_Homo sapiens_hsa000300.74360072
101Metabolic pathways_Homo sapiens_hsa011000.74079697
102Spliceosome_Homo sapiens_hsa030400.73250597
103Folate biosynthesis_Homo sapiens_hsa007900.72125570
104Cholinergic synapse_Homo sapiens_hsa047250.71092299
105Estrogen signaling pathway_Homo sapiens_hsa049150.69382881
106Dopaminergic synapse_Homo sapiens_hsa047280.69335393
107Peroxisome_Homo sapiens_hsa041460.69249094
108Morphine addiction_Homo sapiens_hsa050320.69139039
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68853570
110Circadian rhythm_Homo sapiens_hsa047100.68338853
111One carbon pool by folate_Homo sapiens_hsa006700.68177603
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67619116
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67419430
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67369749
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66973332
116Insulin secretion_Homo sapiens_hsa049110.66777325
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65730935
118RNA transport_Homo sapiens_hsa030130.65626733
119HTLV-I infection_Homo sapiens_hsa051660.64853324
120T cell receptor signaling pathway_Homo sapiens_hsa046600.63760613
121Insulin resistance_Homo sapiens_hsa049310.62783320
122B cell receptor signaling pathway_Homo sapiens_hsa046620.62490114
123Glutamatergic synapse_Homo sapiens_hsa047240.62339815
124Collecting duct acid secretion_Homo sapiens_hsa049660.60928983
125Glutathione metabolism_Homo sapiens_hsa004800.60690603
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.59688328
127ErbB signaling pathway_Homo sapiens_hsa040120.59626587
128Amphetamine addiction_Homo sapiens_hsa050310.58522722
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.58264559
130Non-small cell lung cancer_Homo sapiens_hsa052230.58107195
131Renin secretion_Homo sapiens_hsa049240.58000781
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57225192
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56827749
134Steroid biosynthesis_Homo sapiens_hsa001000.56490375
135Salivary secretion_Homo sapiens_hsa049700.56074275
136Acute myeloid leukemia_Homo sapiens_hsa052210.55398084
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.54771369
138Renal cell carcinoma_Homo sapiens_hsa052110.54428906
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54383879
140Arginine biosynthesis_Homo sapiens_hsa002200.53450777
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53287507
142Regulation of autophagy_Homo sapiens_hsa041400.50957499
143Pancreatic cancer_Homo sapiens_hsa052120.50464175
144Cocaine addiction_Homo sapiens_hsa050300.49953610
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49742579
146Fructose and mannose metabolism_Homo sapiens_hsa000510.49479194
147Melanogenesis_Homo sapiens_hsa049160.48652778
148Endometrial cancer_Homo sapiens_hsa052130.48235454
149beta-Alanine metabolism_Homo sapiens_hsa004100.47603872
150Antigen processing and presentation_Homo sapiens_hsa046120.47160167
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46691110
152FoxO signaling pathway_Homo sapiens_hsa040680.46582373
153Starch and sucrose metabolism_Homo sapiens_hsa005000.46131537
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45262143
155Tryptophan metabolism_Homo sapiens_hsa003800.45197238
156Hippo signaling pathway_Homo sapiens_hsa043900.44803242
157Nicotine addiction_Homo sapiens_hsa050330.44351071
158Taste transduction_Homo sapiens_hsa047420.43571116
159Wnt signaling pathway_Homo sapiens_hsa043100.42999085
160Axon guidance_Homo sapiens_hsa043600.42408959
161Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40196143
162Alcoholism_Homo sapiens_hsa050340.39141406
163Selenocompound metabolism_Homo sapiens_hsa004500.37960013

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