ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	6.87361498
2	endoderm formation (GO:0001706)	6.86282386
3	cellular response to electrical stimulus (GO:0071257)	6.62595062
4	cerebellar Purkinje cell differentiation (GO:0021702)	6.06941063
5	somite rostral/caudal axis specification (GO:0032525)	6.06019587
6	glomerulus development (GO:0032835)	5.68028762
7	positive regulation of gastrulation (GO:2000543)	5.54412077
8	primitive streak formation (GO:0090009)	5.41075663
9	cytoplasmic mRNA processing body assembly (GO:0033962)	5.31280496
10	uterus development (GO:0060065)	5.30489207
11	seminiferous tubule development (GO:0072520)	5.25172652
12	prenylation (GO:0097354)	5.15554924
13	protein prenylation (GO:0018342)	5.15554924
14	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	5.01200154
15	DNA double-strand break processing (GO:0000729)	4.87182352
16	DNA replication-dependent nucleosome assembly (GO:0006335)	4.85944549
17	DNA replication-dependent nucleosome organization (GO:0034723)	4.85944549
18	head development (GO:0060322)	4.84140275
19	protein import into peroxisome matrix (GO:0016558)	4.81835842
20	embryonic retina morphogenesis in camera-type eye (GO:0060059)	4.62906707
21	female genitalia development (GO:0030540)	4.50681355
22	vagina development (GO:0060068)	4.49106254
23	regulation of axon guidance (GO:1902667)	4.43366310
24	relaxation of smooth muscle (GO:0044557)	4.41690740
25	regulation of sensory perception of pain (GO:0051930)	4.36334273
26	regulation of sensory perception (GO:0051931)	4.36334273
27	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.27615058
28	protein-cofactor linkage (GO:0018065)	4.23913224
29	detection of light stimulus involved in sensory perception (GO:0050962)	4.10923034
30	detection of light stimulus involved in visual perception (GO:0050908)	4.10923034
31	regulation of axon extension involved in axon guidance (GO:0048841)	4.10900617
32	regulation of mesoderm development (GO:2000380)	3.96669565
33	signal transduction involved in regulation of gene expression (GO:0023019)	3.95012983
34	DNA integration (GO:0015074)	3.92186736
35	negative regulation of axon guidance (GO:1902668)	3.86179814
36	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.85144652
37	fucose catabolic process (GO:0019317)	3.82555914
38	L-fucose metabolic process (GO:0042354)	3.82555914
39	L-fucose catabolic process (GO:0042355)	3.82555914
40	replication fork processing (GO:0031297)	3.79210640
41	embryonic viscerocranium morphogenesis (GO:0048703)	3.78920186
42	kidney morphogenesis (GO:0060993)	3.78038391
43	urogenital system development (GO:0001655)	3.77476375
44	interferon-gamma production (GO:0032609)	3.76755871
45	telencephalon development (GO:0021537)	3.75921470
46	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.74683647
47	mitochondrial DNA replication (GO:0006264)	3.74239612
48	post-embryonic morphogenesis (GO:0009886)	3.66187794
49	neural tube formation (GO:0001841)	3.65724511
50	histone H3-K36 demethylation (GO:0070544)	3.64049153
51	regulation of female gonad development (GO:2000194)	3.58066024
52	nucleotide transmembrane transport (GO:1901679)	3.48817885
53	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.46017914
54	retina layer formation (GO:0010842)	3.29795357
55	synaptic vesicle endocytosis (GO:0048488)	3.27667180
56	olfactory bulb development (GO:0021772)	3.25214801
57	gastrulation (GO:0007369)	3.25214659
58	positive regulation of CREB transcription factor activity (GO:0032793)	3.21889077
59	purine-containing compound salvage (GO:0043101)	3.19821556
60	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.19362216
61	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.19273760
62	regulation of synaptic transmission, glutamatergic (GO:0051966)	3.13483214
63	limb bud formation (GO:0060174)	3.09184977
64	behavioral response to nicotine (GO:0035095)	3.08049932
65	regulation of chromatin silencing (GO:0031935)	3.03556792
66	cellular ketone body metabolic process (GO:0046950)	3.02077990
67	negative regulation of activin receptor signaling pathway (GO:0032926)	3.01845255
68	histone H4-K12 acetylation (GO:0043983)	2.97699592
69	phospholipid scrambling (GO:0017121)	2.97073061
70	cerebral cortex neuron differentiation (GO:0021895)	2.96285095
71	gastrulation with mouth forming second (GO:0001702)	2.95566116
72	proline transport (GO:0015824)	2.94804728
73	regulation of response to tumor cell (GO:0002834)	2.94320927
74	positive regulation of response to tumor cell (GO:0002836)	2.94320927
75	positive regulation of immune response to tumor cell (GO:0002839)	2.94320927
76	regulation of immune response to tumor cell (GO:0002837)	2.94320927
77	negative regulation of multicellular organism growth (GO:0040015)	2.90752923
78	stress granule assembly (GO:0034063)	2.89084462
79	spinal cord association neuron differentiation (GO:0021527)	2.88326212
80	axoneme assembly (GO:0035082)	2.82209295
81	pancreas development (GO:0031016)	2.80602063
82	regulation of activin receptor signaling pathway (GO:0032925)	2.78655461
83	cell differentiation in spinal cord (GO:0021515)	2.76565597
84	positive regulation of developmental pigmentation (GO:0048087)	2.75086854
85	embryonic axis specification (GO:0000578)	2.73032025
86	epithelial cell differentiation involved in kidney development (GO:0035850)	2.72532780
87	glutamate receptor signaling pathway (GO:0007215)	2.72163377
88	ketone body metabolic process (GO:1902224)	2.70422862
89	opioid receptor signaling pathway (GO:0038003)	2.67504055
90	coenzyme catabolic process (GO:0009109)	2.67271715
91	sympathetic nervous system development (GO:0048485)	2.66481059
92	establishment of protein localization to peroxisome (GO:0072663)	2.65053756
93	protein localization to peroxisome (GO:0072662)	2.65053756
94	protein targeting to peroxisome (GO:0006625)	2.65053756
95	histone H4-K16 acetylation (GO:0043984)	2.62468602
96	sialylation (GO:0097503)	2.61539976
97	pericardium development (GO:0060039)	2.59508701
98	sodium-independent organic anion transport (GO:0043252)	2.57091510
99	positive regulation of amino acid transport (GO:0051957)	2.57008118
100	dendritic spine morphogenesis (GO:0060997)	2.54650586

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.51307875
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.43446945
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.30575439
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.11707131
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11033338
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.05704777
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.90058177
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88885882
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51724716
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51017912
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49331890
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.42487568
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.42485677
14	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.26553699
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.07815337
16	P300_19829295_ChIP-Seq_ESCs_Human	2.02217255
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00992815
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95959304
19	EWS_26573619_Chip-Seq_HEK293_Human	1.91846327
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90691756
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.86483339
22	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.82493163
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.75037094
24	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.67248976
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.66700059
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66700059
27	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.63004505
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.60980935
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59354311
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59354311
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58782251
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57632909
33	FUS_26573619_Chip-Seq_HEK293_Human	1.52338143
34	TCF4_23295773_ChIP-Seq_U87_Human	1.52020498
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51669067
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51485090
37	AR_25329375_ChIP-Seq_VCAP_Human	1.50393613
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48398454
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.47569302
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.46061225
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45752242
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45400643
43	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.43292377
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43156359
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41412536
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.38897038
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37567442
48	GATA1_22025678_ChIP-Seq_K562_Human	1.37464304
49	STAT3_23295773_ChIP-Seq_U87_Human	1.35651322
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35079397
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35079397
52	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33832467
53	VDR_22108803_ChIP-Seq_LS180_Human	1.31897173
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29395092
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29395092
56	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.28378067
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.27214488
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26514156
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26383656
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.23595435
61	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.21586533
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20888445
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20359799
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20311655
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17525873
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16735569
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16255763
68	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15971866
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.12175742
70	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.11333894
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10549548
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10064324
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09550405
74	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.08966120
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08738150
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08567845
77	VDR_24787735_ChIP-Seq_THP-1_Human	1.07575654
78	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06824366
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.04492920
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03308021
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03264597
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03168458
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02825812
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.02096047
85	AR_20517297_ChIP-Seq_VCAP_Human	1.01954410
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01181974
87	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99446368
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98555275
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98468602
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97715412
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97009112
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96873570
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.95995804
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.94144566
95	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94026228
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.93263266
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91879768
98	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.91516261
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90214131
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90198986

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	7.77607059
2	MP0003283_abnormal_digestive_organ	4.90441197
3	MP0003880_abnormal_central_pattern	3.65771400
4	MP0005423_abnormal_somatic_nervous	3.21246297
5	MP0009046_muscle_twitch	3.10452339
6	MP0002822_catalepsy	3.00831788
7	MP0006054_spinal_hemorrhage	2.90628691
8	MP0005386_behavior/neurological_phenoty	2.56243984
9	MP0004924_abnormal_behavior	2.56243984
10	MP0002736_abnormal_nociception_after	2.49151988
11	MP0001968_abnormal_touch/_nociception	2.37809231
12	MP0000538_abnormal_urinary_bladder	2.24085600
13	MP0002557_abnormal_social/conspecific_i	2.21564858
14	MP0006276_abnormal_autonomic_nervous	2.17704470
15	MP0003121_genomic_imprinting	2.04486041
16	MP0008995_early_reproductive_senescence	1.97026090
17	MP0002272_abnormal_nervous_system	1.96812839
18	MP0006072_abnormal_retinal_apoptosis	1.95725704
19	MP0002735_abnormal_chemical_nociception	1.94695844
20	MP0001986_abnormal_taste_sensitivity	1.84391569
21	MP0002102_abnormal_ear_morphology	1.78796918
22	MP0003195_calcinosis	1.77892753
23	MP0002751_abnormal_autonomic_nervous	1.68428518
24	MP0003252_abnormal_bile_duct	1.64069875
25	MP0005084_abnormal_gallbladder_morpholo	1.63628787
26	MP0002572_abnormal_emotion/affect_behav	1.61086569
27	MP0003119_abnormal_digestive_system	1.60702861
28	MP0005551_abnormal_eye_electrophysiolog	1.57723573
29	MP0000569_abnormal_digit_pigmentation	1.57280065
30	MP0001485_abnormal_pinna_reflex	1.51914851
31	MP0000516_abnormal_urinary_system	1.46989183
32	MP0005367_renal/urinary_system_phenotyp	1.46989183
33	MP0008877_abnormal_DNA_methylation	1.41585291
34	MP0002067_abnormal_sensory_capabilities	1.41308518
35	MP0003787_abnormal_imprinting	1.40027715
36	MP0004742_abnormal_vestibular_system	1.35277832
37	MP0001529_abnormal_vocalization	1.33879268
38	MP0002971_abnormal_brown_adipose	1.33576515
39	MP0003122_maternal_imprinting	1.21740164
40	MP0008775_abnormal_heart_ventricle	1.18284453
41	MP0005253_abnormal_eye_physiology	1.16181808
42	MP0004043_abnormal_pH_regulation	1.14355151
43	MP0005220_abnormal_exocrine_pancreas	1.10948641
44	MP0009697_abnormal_copulation	1.10832623
45	MP0008569_lethality_at_weaning	1.07765935
46	MP0000462_abnormal_digestive_system	1.06425346
47	MP0004133_heterotaxia	1.04521819
48	MP0002063_abnormal_learning/memory/cond	1.01224719
49	MP0000383_abnormal_hair_follicle	1.00599018
50	MP0004147_increased_porphyrin_level	0.99801327
51	MP0005623_abnormal_meninges_morphology	0.98738124
52	MP0000955_abnormal_spinal_cord	0.98039774
53	MP0003635_abnormal_synaptic_transmissio	0.94081598
54	MP0001502_abnormal_circadian_rhythm	0.93202396
55	MP0000230_abnormal_systemic_arterial	0.91164867
56	MP0005645_abnormal_hypothalamus_physiol	0.89646115
57	MP0002733_abnormal_thermal_nociception	0.89259700
58	MP0008057_abnormal_DNA_replication	0.87132765
59	MP0000534_abnormal_ureter_morphology	0.86576942
60	MP0002938_white_spotting	0.85698277
61	MP0004085_abnormal_heartbeat	0.83134187
62	MP0003724_increased_susceptibility_to	0.82393639
63	MP0000778_abnormal_nervous_system	0.81670252
64	MP0005187_abnormal_penis_morphology	0.81181493
65	MP0005075_abnormal_melanosome_morpholog	0.78690382
66	MP0010329_abnormal_lipoprotein_level	0.77150120
67	MP0009745_abnormal_behavioral_response	0.76626225
68	MP0001970_abnormal_pain_threshold	0.73302305
69	MP0000049_abnormal_middle_ear	0.73100198
70	MP0002882_abnormal_neuron_morphology	0.72706586
71	MP0005595_abnormal_vascular_smooth	0.71008964
72	MP0000647_abnormal_sebaceous_gland	0.69571983
73	MP0008872_abnormal_physiological_respon	0.69511732
74	MP0001545_abnormal_hematopoietic_system	0.69498083
75	MP0005397_hematopoietic_system_phenotyp	0.69498083
76	MP0001501_abnormal_sleep_pattern	0.68546211
77	MP0001944_abnormal_pancreas_morphology	0.66338817
78	MP0002932_abnormal_joint_morphology	0.65417178
79	MP0008260_abnormal_autophagy	0.64700983
80	MP0009840_abnormal_foam_cell	0.64338634
81	MP0008058_abnormal_DNA_repair	0.63094733
82	MP0001324_abnormal_eye_pigmentation	0.63072961
83	MP0003828_pulmonary_edema	0.62472911
84	MP0000470_abnormal_stomach_morphology	0.62218568
85	MP0002066_abnormal_motor_capabilities/c	0.61666339
86	MP0000372_irregular_coat_pigmentation	0.61495897
87	MP0005266_abnormal_metabolism	0.60023137
88	MP0001486_abnormal_startle_reflex	0.59616765
89	MP0008961_abnormal_basal_metabolism	0.59490491
90	MP0003806_abnormal_nucleotide_metabolis	0.57845150
91	MP0001119_abnormal_female_reproductive	0.57710430
92	MP0003698_abnormal_male_reproductive	0.57678994
93	MP0003959_abnormal_lean_body	0.57056093
94	MP0002111_abnormal_tail_morphology	0.55528960
95	MP0001727_abnormal_embryo_implantation	0.55518543
96	MP0002752_abnormal_somatic_nervous	0.54400238
97	MP0008874_decreased_physiological_sensi	0.53651463
98	MP0002064_seizures	0.52977326
99	MP0003861_abnormal_nervous_system	0.52274229
100	MP0003632_abnormal_nervous_system	0.51739229

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dysdiadochokinesis (HP:0002075)	7.11811229
2	Genetic anticipation (HP:0003743)	6.86538775
3	Abnormal pancreas size (HP:0012094)	6.02406483
4	Renal cortical cysts (HP:0000803)	5.18225293
5	Prominent supraorbital ridges (HP:0000336)	4.54743850
6	Hyperventilation (HP:0002883)	4.00571830
7	Urinary bladder sphincter dysfunction (HP:0002839)	3.99260355
8	Shawl scrotum (HP:0000049)	3.98976699
9	Abnormality of the renal cortex (HP:0011035)	3.87697106
10	Progressive cerebellar ataxia (HP:0002073)	3.77467715
11	Long nose (HP:0003189)	3.66155672
12	Action tremor (HP:0002345)	3.53827994
13	Dysmetric saccades (HP:0000641)	3.35723547
14	Birth length less than 3rd percentile (HP:0003561)	3.29017872
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.24060851
16	Horizontal nystagmus (HP:0000666)	3.22684765
17	Esotropia (HP:0000565)	3.20879643
18	Broad alveolar ridges (HP:0000187)	3.09257928
19	Abnormality of saccadic eye movements (HP:0000570)	3.00279095
20	Limb dystonia (HP:0002451)	2.88875745
21	Protruding tongue (HP:0010808)	2.87684476
22	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.83353290
23	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.83353290
24	Microretrognathia (HP:0000308)	2.80868754
25	Choroideremia (HP:0001139)	2.72963589
26	Methylmalonic acidemia (HP:0002912)	2.70927531
27	Gaze-evoked nystagmus (HP:0000640)	2.64023520
28	Abnormal respiratory motile cilium physiology (HP:0012261)	2.58724046
29	Volvulus (HP:0002580)	2.58118577
30	Flat face (HP:0012368)	2.52757580
31	Type II lissencephaly (HP:0007260)	2.50917253
32	Hypoplasia of the fovea (HP:0007750)	2.50724466
33	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.50724466
34	Gout (HP:0001997)	2.43626294
35	Bulbous nose (HP:0000414)	2.39193005
36	Testicular atrophy (HP:0000029)	2.27715453
37	Abnormality of the corticospinal tract (HP:0002492)	2.26824643
38	Ulnar claw (HP:0001178)	2.26410572
39	Lissencephaly (HP:0001339)	2.26388628
40	Hemiparesis (HP:0001269)	2.25485155
41	Inability to walk (HP:0002540)	2.23854230
42	Chronic bronchitis (HP:0004469)	2.19479778
43	Congenital stationary night blindness (HP:0007642)	2.18661390
44	Exertional dyspnea (HP:0002875)	2.16555661
45	Large eyes (HP:0001090)	2.14808222
46	Small hand (HP:0200055)	2.12990292
47	Progressive inability to walk (HP:0002505)	2.12440259
48	Pachygyria (HP:0001302)	2.11806700
49	Insidious onset (HP:0003587)	2.09326677
50	Termporal pattern (HP:0011008)	2.09326677
51	Disproportionate short-trunk short stature (HP:0003521)	2.08876113
52	Delayed puberty (HP:0000823)	2.08366613
53	Cerebellar dysplasia (HP:0007033)	2.05187017
54	Methylmalonic aciduria (HP:0012120)	2.04596602
55	Abnormality of the aortic arch (HP:0012303)	2.03011471
56	Impaired vibratory sensation (HP:0002495)	2.02494770
57	Tented upper lip vermilion (HP:0010804)	2.01733519
58	Postural tremor (HP:0002174)	2.00698580
59	Hyperglycinuria (HP:0003108)	2.00197215
60	Rhinitis (HP:0012384)	1.98630270
61	Tachypnea (HP:0002789)	1.98237715
62	Pancreatic fibrosis (HP:0100732)	1.98081311
63	Mesangial abnormality (HP:0001966)	1.95899728
64	Gastroesophageal reflux (HP:0002020)	1.95800907
65	Abnormal drinking behavior (HP:0030082)	1.93183064
66	Polydipsia (HP:0001959)	1.93183064
67	Anencephaly (HP:0002323)	1.91980715
68	Abnormality of the fovea (HP:0000493)	1.90753822
69	Abolished electroretinogram (ERG) (HP:0000550)	1.89819254
70	Polyphagia (HP:0002591)	1.87261759
71	Clumsiness (HP:0002312)	1.85401084
72	Pendular nystagmus (HP:0012043)	1.85257481
73	Congenital, generalized hypertrichosis (HP:0004540)	1.84496341
74	Decreased central vision (HP:0007663)	1.84135985
75	Preaxial foot polydactyly (HP:0001841)	1.83218000
76	Polyuria (HP:0000103)	1.82172956
77	Ectopic kidney (HP:0000086)	1.80162792
78	Rib fusion (HP:0000902)	1.78808860
79	Intestinal atresia (HP:0011100)	1.78458344
80	Anal stenosis (HP:0002025)	1.78428819
81	Postural instability (HP:0002172)	1.77958700
82	Abnormal ciliary motility (HP:0012262)	1.77688571
83	Low posterior hairline (HP:0002162)	1.77335141
84	Congenital malformation of the right heart (HP:0011723)	1.77037653
85	Double outlet right ventricle (HP:0001719)	1.77037653
86	Tapered finger (HP:0001182)	1.76213741
87	Morphological abnormality of the pyramidal tract (HP:0002062)	1.74091186
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71797528
89	Abnormality of binocular vision (HP:0011514)	1.71497054
90	Diplopia (HP:0000651)	1.71497054
91	Abnormality of the musculature of the pelvis (HP:0001469)	1.70802390
92	Abnormality of the hip-girdle musculature (HP:0001445)	1.70802390
93	Severe muscular hypotonia (HP:0006829)	1.67133968
94	Pancreatic cysts (HP:0001737)	1.67060393
95	Hypoalbuminemia (HP:0003073)	1.66516992
96	Abnormal albumin level (HP:0012116)	1.66516992
97	Thin upper lip vermilion (HP:0000219)	1.66256602
98	Thyroiditis (HP:0100646)	1.65263473
99	Dysmetria (HP:0001310)	1.64819194
100	Toxemia of pregnancy (HP:0100603)	1.63777133

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.56766190
2	STK39	3.72522645
3	WNK4	3.56901777
4	BMPR1B	3.50299774
5	OXSR1	2.91930717
6	FRK	2.87644166
7	PKN2	2.75213447
8	AKT3	2.64135555
9	CASK	2.23618812
10	FLT3	2.14857713
11	PDK2	2.06120178
12	DYRK3	2.02736841
13	MAP3K4	2.00796231
14	MAP2K6	1.97959342
15	ADRBK2	1.90731323
16	MAPK13	1.89100406
17	TGFBR1	1.76644124
18	EPHA3	1.62889118
19	DAPK2	1.56632743
20	SIK3	1.53957670
21	MAP4K2	1.39425181
22	SIK2	1.38270398
23	TLK1	1.33564013
24	ADRBK1	1.32023500
25	MARK1	1.24150296
26	MAPK15	1.19679835
27	SGK2	1.14837772
28	KIT	1.08010818
29	GRK1	1.01028046
30	MAP2K7	0.96911324
31	BMX	0.95451407
32	ZAK	0.94887366
33	TNIK	0.92180443
34	CSF1R	0.89562808
35	TAOK1	0.86451683
36	PAK3	0.86017198
37	MAP3K10	0.85977196
38	ERBB4	0.85783062
39	PKN1	0.85317385
40	SGK223	0.83298885
41	SGK494	0.83298885
42	MST4	0.80629371
43	TGFBR2	0.79953001
44	SGK3	0.79503099
45	MARK3	0.76200015
46	ERBB3	0.75171048
47	NUAK1	0.71765295
48	PINK1	0.71598118
49	TAOK3	0.69124812
50	WNK1	0.68638851
51	PRKCE	0.67599251
52	PNCK	0.67359059
53	TRPM7	0.65540169
54	SRPK1	0.65265208
55	PLK2	0.64190089
56	TRIM28	0.63463922
57	PRKD2	0.62503044
58	IRAK1	0.61206401
59	EPHB1	0.58450773
60	CAMK1D	0.57295163
61	MAPKAPK3	0.56694694
62	PBK	0.55139740
63	MAP2K4	0.51082667
64	MKNK2	0.50195999
65	CAMK4	0.49916076
66	RPS6KA5	0.49894813
67	PRKCG	0.48563050
68	UHMK1	0.48527004
69	ROCK1	0.48151035
70	CAMK2A	0.48108237
71	CAMK2B	0.47039402
72	JAK1	0.46871548
73	BCKDK	0.45486263
74	OBSCN	0.44424503
75	INSRR	0.44384835
76	MAP2K3	0.42348434
77	PRKCH	0.42265582
78	MAP2K1	0.39135740
79	SYK	0.38466729
80	NTRK2	0.37323163
81	PTK2B	0.36625015
82	WEE1	0.36301166
83	STK38	0.36020538
84	TEC	0.35835993
85	JAK2	0.35694152
86	MAPK8	0.35129418
87	CCNB1	0.33713205
88	CAMK2D	0.33016316
89	PIM2	0.32748508
90	NEK2	0.31330459
91	FGR	0.31056930
92	ZAP70	0.30472167
93	PRKCA	0.29660536
94	MAPK4	0.29533821
95	PRKACG	0.26791798
96	MAPK7	0.26635892
97	PRKACA	0.26581740
98	SGK1	0.26150378
99	DDR2	0.24314895
100	FGFR3	0.23828642

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taste transduction_Homo sapiens_hsa04742	3.04749863
2	Caffeine metabolism_Homo sapiens_hsa00232	2.99611873
3	Propanoate metabolism_Homo sapiens_hsa00640	2.89002388
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.58248288
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.57535884
6	Long-term depression_Homo sapiens_hsa04730	2.44782802
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44774756
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.42817914
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.29796544
10	Regulation of autophagy_Homo sapiens_hsa04140	2.19975155
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.05746437
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.98830026
13	Phototransduction_Homo sapiens_hsa04744	1.89669570
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.84575910
15	Nicotine addiction_Homo sapiens_hsa05033	1.80922031
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.80554682
17	Butanoate metabolism_Homo sapiens_hsa00650	1.74576970
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.70187629
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.69310789
20	ABC transporters_Homo sapiens_hsa02010	1.65498342
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.64258229
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.60723367
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.55407120
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.49546912
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.45335180
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.44801465
27	Homologous recombination_Homo sapiens_hsa03440	1.44655579
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.43798846
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.40563139
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39533508
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.37999289
32	Olfactory transduction_Homo sapiens_hsa04740	1.36380915
33	Alcoholism_Homo sapiens_hsa05034	1.34596187
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.34583626
35	One carbon pool by folate_Homo sapiens_hsa00670	1.29528086
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24409125
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.24277227
38	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.19516308
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13646345
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11295400
41	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.06215718
42	Peroxisome_Homo sapiens_hsa04146	1.05414658
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.02031264
44	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.01542376
45	RNA polymerase_Homo sapiens_hsa03020	1.01149816
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93248748
47	Basal transcription factors_Homo sapiens_hsa03022	0.91257429
48	Lysine degradation_Homo sapiens_hsa00310	0.90484025
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.89644177
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.88719942
51	Salivary secretion_Homo sapiens_hsa04970	0.87733809
52	RNA degradation_Homo sapiens_hsa03018	0.87475030
53	FoxO signaling pathway_Homo sapiens_hsa04068	0.87362966
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85299126
55	Serotonergic synapse_Homo sapiens_hsa04726	0.82975131
56	Purine metabolism_Homo sapiens_hsa00230	0.81238988
57	Gap junction_Homo sapiens_hsa04540	0.77474500
58	Arginine biosynthesis_Homo sapiens_hsa00220	0.76434487
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74807413
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.73799851
61	Platelet activation_Homo sapiens_hsa04611	0.72054009
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70850623
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70768849
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.67369933
65	Circadian rhythm_Homo sapiens_hsa04710	0.66899324
66	Renin secretion_Homo sapiens_hsa04924	0.65444848
67	GABAergic synapse_Homo sapiens_hsa04727	0.65333585
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65207634
69	Long-term potentiation_Homo sapiens_hsa04720	0.62937425
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62864170
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.59955168
72	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59725245
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59324629
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.54893282
75	Retinol metabolism_Homo sapiens_hsa00830	0.54126352
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51838442
77	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.49554801
78	Morphine addiction_Homo sapiens_hsa05032	0.47943910
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47069027
80	Circadian entrainment_Homo sapiens_hsa04713	0.46003948
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44932027
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44579306
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43172697
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42853746
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41740215
86	Oxidative phosphorylation_Homo sapiens_hsa00190	0.40879107
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40552779
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40347701
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39879230
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39479632
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39225663
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38891502
93	Pancreatic secretion_Homo sapiens_hsa04972	0.36225027
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36095112
95	Metabolic pathways_Homo sapiens_hsa01100	0.35607160
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.34868526
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.32201189
98	Insulin secretion_Homo sapiens_hsa04911	0.30582901
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29659248
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.28701898

MYL6BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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