ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.83964067
2	regulation of regulatory T cell differentiation (GO:0045589)	5.43664248
3	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.41081674
4	response to pheromone (GO:0019236)	4.78804109
5	negative regulation of B cell apoptotic process (GO:0002903)	4.77322306
6	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.72593172
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.61225747
8	leukotriene biosynthetic process (GO:0019370)	4.57531768
9	regulation of isotype switching to IgG isotypes (GO:0048302)	4.56804156
10	ATP synthesis coupled proton transport (GO:0015986)	4.48743135
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.48743135
12	cytidine catabolic process (GO:0006216)	4.44403064
13	cytidine deamination (GO:0009972)	4.44403064
14	cytidine metabolic process (GO:0046087)	4.44403064
15	positive regulation of interleukin-17 production (GO:0032740)	4.39460692
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.34415603
17	water-soluble vitamin biosynthetic process (GO:0042364)	4.34218356
18	DNA deamination (GO:0045006)	4.32548536
19	proteasome assembly (GO:0043248)	4.25527493
20	actin nucleation (GO:0045010)	4.23788465
21	protein neddylation (GO:0045116)	4.13799622
22	L-fucose catabolic process (GO:0042355)	4.07377938
23	fucose catabolic process (GO:0019317)	4.07377938
24	L-fucose metabolic process (GO:0042354)	4.07377938
25	regulation of immunoglobulin secretion (GO:0051023)	4.01723482
26	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.94537514
27	glutathione biosynthetic process (GO:0006750)	3.90761931
28	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.71911195
29	adaptation of signaling pathway (GO:0023058)	3.68203908
30	nonribosomal peptide biosynthetic process (GO:0019184)	3.58309070
31	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.45618761
32	pseudouridine synthesis (GO:0001522)	3.41872436
33	regulation of T cell mediated cytotoxicity (GO:0001914)	3.35000521
34	platelet dense granule organization (GO:0060155)	3.34265529
35	negative regulation of monooxygenase activity (GO:0032769)	3.31890477
36	regulation of hexokinase activity (GO:1903299)	3.28019255
37	regulation of glucokinase activity (GO:0033131)	3.28019255
38	behavioral response to nicotine (GO:0035095)	3.21496138
39	regulation of chronic inflammatory response (GO:0002676)	3.20273416
40	regulation of activation of Janus kinase activity (GO:0010533)	3.16320656
41	transcription from mitochondrial promoter (GO:0006390)	3.14315537
42	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.11772888
43	response to gravity (GO:0009629)	3.02154231
44	icosanoid biosynthetic process (GO:0046456)	3.00408286
45	fatty acid derivative biosynthetic process (GO:1901570)	3.00408286
46	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.93860290
47	lymph node development (GO:0048535)	2.89831559
48	proline transport (GO:0015824)	2.85412597
49	positive regulation of cell fate commitment (GO:0010455)	2.82226963
50	regulation of mitochondrial fission (GO:0090140)	2.81970931
51	phosphatidylethanolamine metabolic process (GO:0046337)	2.77368120
52	positive regulation of defense response to virus by host (GO:0002230)	2.77017046
53	ATP biosynthetic process (GO:0006754)	2.76299866
54	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.74636431
55	regulation of B cell apoptotic process (GO:0002902)	2.73144451
56	leukotriene metabolic process (GO:0006691)	2.67504901
57	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.67243604
58	UMP biosynthetic process (GO:0006222)	2.67243604
59	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.67243604
60	UMP metabolic process (GO:0046049)	2.67243604
61	hydrogen ion transmembrane transport (GO:1902600)	2.63747329
62	positive regulation of T cell migration (GO:2000406)	2.63008947
63	cellular response to interleukin-15 (GO:0071350)	2.60744401
64	regulation of cellular amino acid metabolic process (GO:0006521)	2.59992191
65	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.58252373
66	eosinophil chemotaxis (GO:0048245)	2.56400105
67	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.55947553
68	glycerol metabolic process (GO:0006071)	2.55610703
69	plasma membrane fusion (GO:0045026)	2.55515723
70	reciprocal DNA recombination (GO:0035825)	2.54997792
71	reciprocal meiotic recombination (GO:0007131)	2.54997792
72	positive regulation of lamellipodium assembly (GO:0010592)	2.54672208
73	unsaturated fatty acid biosynthetic process (GO:0006636)	2.54603885
74	positive regulation of respiratory burst (GO:0060267)	2.54330663
75	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.53176387
76	proton transport (GO:0015992)	2.53016602
77	cellular response to nicotine (GO:0071316)	2.51812879
78	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51478482
79	positive regulation of isotype switching (GO:0045830)	2.51219247
80	exogenous drug catabolic process (GO:0042738)	2.51106696
81	glutathione metabolic process (GO:0006749)	2.49602218
82	myoblast migration (GO:0051451)	2.48184163
83	interferon-gamma secretion (GO:0072643)	2.47789142
84	auditory receptor cell differentiation (GO:0042491)	2.45565941
85	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.45086709
86	negative regulation of viral transcription (GO:0032897)	2.44938980
87	electron transport chain (GO:0022900)	2.44509009
88	hydrogen transport (GO:0006818)	2.44022317
89	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.43769974
90	regulation of cilium movement (GO:0003352)	2.41662506
91	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.41397838
92	glutathione derivative metabolic process (GO:1901685)	2.40698662
93	glutathione derivative biosynthetic process (GO:1901687)	2.40698662
94	positive regulation of DNA recombination (GO:0045911)	2.40603296
95	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.40140404
96	regulation of triglyceride catabolic process (GO:0010896)	2.39660914
97	fucosylation (GO:0036065)	2.39486710
98	respiratory electron transport chain (GO:0022904)	2.38998021
99	cobalamin metabolic process (GO:0009235)	2.38204505
100	negative regulation by host of viral transcription (GO:0043922)	2.38074676

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.74197090
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.66017606
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.11885041
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.95395081
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73623470
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.71447278
7	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.56680653
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45976574
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43082366
10	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.42247645
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41361674
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.29738076
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.27707646
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20757007
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05853249
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.05386254
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00803918
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95405540
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94962065
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.93699851
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85140734
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.82089327
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78895467
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75108063
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.73051058
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.67154387
27	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.64846856
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64296628
29	NANOG_19829295_ChIP-Seq_ESCs_Human	1.62834080
30	SOX2_19829295_ChIP-Seq_ESCs_Human	1.62834080
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61956638
32	NCOR_22424771_ChIP-Seq_293T_Human	1.58978291
33	NANOG_20526341_ChIP-Seq_ESCs_Human	1.53247425
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52994294
35	AR_20517297_ChIP-Seq_VCAP_Human	1.51690856
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51501044
37	GATA3_26560356_Chip-Seq_TH2_Human	1.51442667
38	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.50719689
39	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.44989237
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.43959320
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.40992455
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36994674
43	EWS_26573619_Chip-Seq_HEK293_Human	1.32739053
44	GATA3_27048872_Chip-Seq_THYMUS_Human	1.30441887
45	STAT1_20625510_ChIP-Seq_HELA_Human	1.28874420
46	EZH2_22144423_ChIP-Seq_EOC_Human	1.26933725
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26562499
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26562499
49	ERA_21632823_ChIP-Seq_H3396_Human	1.25392767
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.23728921
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22956662
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17158326
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15635720
54	MYC_19829295_ChIP-Seq_ESCs_Human	1.15141585
55	MYB_26560356_Chip-Seq_TH2_Human	1.15048388
56	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.14453957
57	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.14217144
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13409303
59	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.12320557
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12314424
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12080118
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11820866
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09477567
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08264579
65	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07869844
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.07594587
67	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.06688158
68	P300_19829295_ChIP-Seq_ESCs_Human	1.05163165
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04056117
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02388145
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00453459
72	E2F1_20622854_ChIP-Seq_HELA_Human	0.99762059
73	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99051072
74	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98833998
75	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97432096
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96865402
77	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.96705841
78	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96500453
79	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.95862986
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95243456
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95157134
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94278985
83	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.93537422
84	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.93315391
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92604025
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91940431
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91547466
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91316422
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90925538
90	SA1_27219007_Chip-Seq_Bcells_Human	0.90542932
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89109207
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87970499
93	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.87801949
94	GATA1_22025678_ChIP-Seq_K562_Human	0.87667257
95	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87642028
96	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.87529798
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87030339
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87004219
99	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.86755564
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.86413097

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	4.48451898
2	MP0003195_calcinosis	4.24384039
3	MP0004147_increased_porphyrin_level	3.32150180
4	MP0001835_abnormal_antigen_presentation	3.20189005
5	MP0002736_abnormal_nociception_after	3.18633288
6	MP0001968_abnormal_touch/_nociception	2.90237848
7	MP0003786_premature_aging	2.78596913
8	MP0003646_muscle_fatigue	2.71946022
9	MP0008877_abnormal_DNA_methylation	2.60849852
10	MP0000465_gastrointestinal_hemorrhage	2.30679369
11	MP0005671_abnormal_response_to	2.24518948
12	MP0005645_abnormal_hypothalamus_physiol	2.13084303
13	MP0009785_altered_susceptibility_to	2.06375219
14	MP0002148_abnormal_hypersensitivity_rea	2.04277708
15	MP0005360_urolithiasis	1.97705426
16	MP0008872_abnormal_physiological_respon	1.96712701
17	MP0003806_abnormal_nucleotide_metabolis	1.94851543
18	MP0006054_spinal_hemorrhage	1.90081306
19	MP0008875_abnormal_xenobiotic_pharmacok	1.80018176
20	MP0001853_heart_inflammation	1.78709158
21	MP0001873_stomach_inflammation	1.74126820
22	MP0000604_amyloidosis	1.69499059
23	MP0004742_abnormal_vestibular_system	1.69317374
24	MP0004885_abnormal_endolymph	1.69052523
25	MP0005551_abnormal_eye_electrophysiolog	1.63430151
26	MP0001905_abnormal_dopamine_level	1.60783883
27	MP0002876_abnormal_thyroid_physiology	1.56140390
28	MP0008995_early_reproductive_senescence	1.55674807
29	MP0001501_abnormal_sleep_pattern	1.47561840
30	MP0000749_muscle_degeneration	1.43121140
31	MP0006072_abnormal_retinal_apoptosis	1.43114212
32	MP0001800_abnormal_humoral_immune	1.42368996
33	MP0004145_abnormal_muscle_electrophysio	1.40452862
34	MP0001986_abnormal_taste_sensitivity	1.40048568
35	MP0003283_abnormal_digestive_organ	1.39686770
36	MP0000685_abnormal_immune_system	1.33965944
37	MP0002102_abnormal_ear_morphology	1.28903947
38	MP0002139_abnormal_hepatobiliary_system	1.28583564
39	MP0009333_abnormal_splenocyte_physiolog	1.27363952
40	MP0002837_dystrophic_cardiac_calcinosis	1.24730367
41	MP0005253_abnormal_eye_physiology	1.24671714
42	MP0005332_abnormal_amino_acid	1.23203456
43	MP0002933_joint_inflammation	1.22947857
44	MP0002723_abnormal_immune_serum	1.19980426
45	MP0001485_abnormal_pinna_reflex	1.17917211
46	MP0002163_abnormal_gland_morphology	1.14314591
47	MP0010155_abnormal_intestine_physiology	1.11747505
48	MP0001845_abnormal_inflammatory_respons	1.11458751
49	MP0008775_abnormal_heart_ventricle	1.10650481
50	MP0009764_decreased_sensitivity_to	1.08232384
51	MP0002138_abnormal_hepatobiliary_system	1.08062420
52	MP0002420_abnormal_adaptive_immunity	1.06968832
53	MP0003300_gastrointestinal_ulcer	1.06874343
54	MP0005646_abnormal_pituitary_gland	1.05495409
55	MP0001819_abnormal_immune_cell	1.05478541
56	MP0008961_abnormal_basal_metabolism	1.03659392
57	MP0001790_abnormal_immune_system	1.02734045
58	MP0005387_immune_system_phenotype	1.02734045
59	MP0005379_endocrine/exocrine_gland_phen	1.02699192
60	MP0000427_abnormal_hair_cycle	1.02139135
61	MP0002272_abnormal_nervous_system	1.01415651
62	MP0009643_abnormal_urine_homeostasis	1.00807450
63	MP0001486_abnormal_startle_reflex	1.00790482
64	MP0004036_abnormal_muscle_relaxation	1.00574386
65	MP0002751_abnormal_autonomic_nervous	1.00488504
66	MP0005000_abnormal_immune_tolerance	0.99694215
67	MP0003866_abnormal_defecation	0.98756609
68	MP0003718_maternal_effect	0.98585149
69	MP0005084_abnormal_gallbladder_morpholo	0.97416364
70	MP0002452_abnormal_antigen_presenting	0.96739083
71	MP0001666_abnormal_nutrient_absorption	0.93030629
72	MP0005025_abnormal_response_to	0.92709683
73	MP0004019_abnormal_vitamin_homeostasis	0.92337000
74	MP0005389_reproductive_system_phenotype	0.91276380
75	MP0005085_abnormal_gallbladder_physiolo	0.90815078
76	MP0000013_abnormal_adipose_tissue	0.89712475
77	MP0000372_irregular_coat_pigmentation	0.89564743
78	MP0003045_fibrosis	0.88653179
79	MP0000689_abnormal_spleen_morphology	0.84884806
80	MP0004084_abnormal_cardiac_muscle	0.84487533
81	MP0004142_abnormal_muscle_tone	0.84339980
82	MP0001919_abnormal_reproductive_system	0.83900318
83	MP0004883_abnormal_blood_vessel	0.83752324
84	MP0001664_abnormal_digestion	0.83366092
85	MP0003787_abnormal_imprinting	0.81700957
86	MP0002405_respiratory_system_inflammati	0.81447603
87	MP0001765_abnormal_ion_homeostasis	0.81220233
88	MP0002160_abnormal_reproductive_system	0.81133415
89	MP0002733_abnormal_thermal_nociception	0.79168821
90	MP0005075_abnormal_melanosome_morpholog	0.77922379
91	MP0009745_abnormal_behavioral_response	0.77654934
92	MP0001958_emphysema	0.75499469
93	MP0002638_abnormal_pupillary_reflex	0.74905661
94	MP0003436_decreased_susceptibility_to	0.73678958
95	MP0002557_abnormal_social/conspecific_i	0.72427867
96	MP0001533_abnormal_skeleton_physiology	0.70607237
97	MP0003763_abnormal_thymus_physiology	0.69195156
98	MP0000716_abnormal_immune_system	0.69104430
99	MP0000230_abnormal_systemic_arterial	0.67735647
100	MP0005636_abnormal_mineral_homeostasis	0.67635555

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.91980279
2	Renal cortical cysts (HP:0000803)	4.28786074
3	IgG deficiency (HP:0004315)	3.60721009
4	Acute necrotizing encephalopathy (HP:0006965)	3.59874828
5	Type 2 muscle fiber atrophy (HP:0003554)	3.46024265
6	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.41685012
7	Abnormality of the renal cortex (HP:0011035)	3.19860159
8	Abnormality of vitamin B metabolism (HP:0004340)	3.18290786
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.14898571
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11783437
11	Abolished electroretinogram (ERG) (HP:0000550)	3.10715483
12	Progressive macrocephaly (HP:0004481)	3.06333588
13	Mitochondrial inheritance (HP:0001427)	3.05591783
14	Acute encephalopathy (HP:0006846)	3.03500051
15	Abnormality of homocysteine metabolism (HP:0010919)	2.95789417
16	Homocystinuria (HP:0002156)	2.95789417
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.94697838
18	Congenital stationary night blindness (HP:0007642)	2.87923515
19	Renal Fanconi syndrome (HP:0001994)	2.86875067
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.82260013
21	Muscle fiber atrophy (HP:0100295)	2.79990038
22	Increased hepatocellular lipid droplets (HP:0006565)	2.78802856
23	Congenital, generalized hypertrichosis (HP:0004540)	2.78044698
24	Prostate neoplasm (HP:0100787)	2.71035275
25	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.70353095
26	Lipid accumulation in hepatocytes (HP:0006561)	2.70293972
27	Chorioretinal atrophy (HP:0000533)	2.68701923
28	Methylmalonic acidemia (HP:0002912)	2.60991572
29	Late onset (HP:0003584)	2.60546201
30	Abnormality of macular pigmentation (HP:0008002)	2.58846815
31	Conical tooth (HP:0000698)	2.58267042
32	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.51977826
33	Severe combined immunodeficiency (HP:0004430)	2.51348971
34	Pustule (HP:0200039)	2.48630770
35	Thyroiditis (HP:0100646)	2.42035663
36	Abnormality of the fovea (HP:0000493)	2.41525981
37	Ulnar deviation of the wrist (HP:0003049)	2.41522818
38	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.41406847
39	Malnutrition (HP:0004395)	2.38783272
40	Increased CSF lactate (HP:0002490)	2.38541893
41	Asplenia (HP:0001746)	2.36134663
42	Pancreatic fibrosis (HP:0100732)	2.30837823
43	Glycosuria (HP:0003076)	2.29725644
44	Abnormality of urine glucose concentration (HP:0011016)	2.29725644
45	Abnormality of the preputium (HP:0100587)	2.28547141
46	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.27047981
47	Disproportionate short-trunk short stature (HP:0003521)	2.24810840
48	Aplasia of the musculature (HP:0100854)	2.23615371
49	Cerebral edema (HP:0002181)	2.21463981
50	Stomach cancer (HP:0012126)	2.20187099
51	Increased IgM level (HP:0003496)	2.20170061
52	Hypoglycemic seizures (HP:0002173)	2.19386904
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18924133
54	Abnormality of T cell number (HP:0011839)	2.18382064
55	Optic disc pallor (HP:0000543)	2.16721165
56	Popliteal pterygium (HP:0009756)	2.16343210
57	Abnormality of eosinophils (HP:0001879)	2.15786892
58	Abnormality of vitamin metabolism (HP:0100508)	2.14153714
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12518271
60	Type I transferrin isoform profile (HP:0003642)	2.11531852
61	Abnormality of the neuromuscular junction (HP:0003398)	2.09804468
62	Fatigable weakness (HP:0003473)	2.09804468
63	Hyperlipoproteinemia (HP:0010980)	2.09348422
64	Abnormality of B cell number (HP:0010975)	2.09344623
65	Oral leukoplakia (HP:0002745)	2.08716180
66	Methylmalonic aciduria (HP:0012120)	2.08536942
67	Poor suck (HP:0002033)	2.08522870
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08490699
69	Pancytopenia (HP:0001876)	2.07673202
70	T lymphocytopenia (HP:0005403)	2.06627854
71	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06366130
72	Abnormality of serum amino acid levels (HP:0003112)	2.02292154
73	Megaloblastic anemia (HP:0001889)	1.99555485
74	Exertional dyspnea (HP:0002875)	1.99185123
75	Decreased central vision (HP:0007663)	1.99166539
76	Reduced antithrombin III activity (HP:0001976)	1.98139993
77	Weak cry (HP:0001612)	1.98105226
78	Abnormality of the prostate (HP:0008775)	1.97654440
79	Increased intramyocellular lipid droplets (HP:0012240)	1.96532705
80	Pancreatic cysts (HP:0001737)	1.96332460
81	Abnormality of chromosome stability (HP:0003220)	1.94693867
82	Nausea (HP:0002018)	1.91968826
83	Meckel diverticulum (HP:0002245)	1.91398727
84	Increased corneal curvature (HP:0100692)	1.90868326
85	Keratoconus (HP:0000563)	1.90868326
86	Testicular atrophy (HP:0000029)	1.90279368
87	Abnormality of placental membranes (HP:0011409)	1.90020219
88	Amniotic constriction ring (HP:0009775)	1.90020219
89	True hermaphroditism (HP:0010459)	1.86940800
90	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.86083535
91	Hypoplasia of the fovea (HP:0007750)	1.86083535
92	Hydroxyprolinuria (HP:0003080)	1.84153451
93	Abnormality of proline metabolism (HP:0010907)	1.84153451
94	Hyperphosphaturia (HP:0003109)	1.83232085
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.83129862
96	Abnormality of glycine metabolism (HP:0010895)	1.83129862
97	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.83126588
98	Hypoproteinemia (HP:0003075)	1.81524459
99	Hyperglycinuria (HP:0003108)	1.81463295
100	Pendular nystagmus (HP:0012043)	1.80764478

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.24450217
2	PINK1	3.44175787
3	TLK1	3.37563780
4	BMPR1B	3.02099153
5	ADRBK2	2.77888564
6	SCYL2	2.60145045
7	VRK2	2.57990292
8	TXK	2.45524658
9	GRK1	2.38648712
10	TEC	2.30338019
11	MAP4K1	2.18391329
12	EPHA3	1.96885478
13	KDR	1.93970638
14	FRK	1.93681146
15	ZAK	1.86951503
16	IKBKB	1.81830362
17	TSSK6	1.65283327
18	BTK	1.62645598
19	ITK	1.62320848
20	WNK3	1.60994636
21	GRK6	1.60420303
22	LIMK1	1.45247516
23	PAK3	1.40836893
24	OBSCN	1.33444468
25	MET	1.32393604
26	IRAK1	1.30088181
27	MAP3K12	1.25968510
28	PASK	1.24105545
29	VRK1	1.21048021
30	NUAK1	1.20069172
31	NTRK3	1.19831657
32	MATK	1.16727666
33	TBK1	1.15536551
34	PAK4	1.12623301
35	TIE1	1.09403071
36	ZAP70	1.09230500
37	IKBKE	1.09015324
38	MYLK	1.07749616
39	ADRBK1	1.07649523
40	STK4	1.06914602
41	EPHB1	1.01208847
42	FES	0.95398092
43	STK38L	0.94837496
44	RPS6KB2	0.92696050
45	JAK1	0.90570248
46	BUB1	0.88825747
47	CSK	0.88380388
48	KIT	0.86351720
49	NTRK1	0.86004451
50	SIK3	0.85387635
51	PLK2	0.85288279
52	IGF1R	0.81499077
53	BCKDK	0.81141803
54	EPHB2	0.80052858
55	STK24	0.75584673
56	INSRR	0.75544248
57	NLK	0.73597202
58	PTK2B	0.72861868
59	MAP3K14	0.71773735
60	SYK	0.69516770
61	LCK	0.66519075
62	ERBB2	0.65934678
63	MAP2K6	0.65690439
64	RIPK4	0.65382049
65	STK38	0.64813836
66	CHUK	0.64520581
67	TYK2	0.63283470
68	STK39	0.62612930
69	GRK5	0.62004551
70	PRKCE	0.58797270
71	PLK3	0.58773471
72	OXSR1	0.57821651
73	LYN	0.55670168
74	DYRK2	0.53196924
75	MAP2K2	0.53067637
76	ABL2	0.52653521
77	TNIK	0.52441483
78	EPHA4	0.52423056
79	TAOK3	0.50898470
80	SIK2	0.50215525
81	PRKG2	0.49723290
82	INSR	0.48150200
83	PRKCA	0.47870532
84	NME1	0.44989075
85	PRKCQ	0.42645350
86	TAF1	0.42446904
87	HCK	0.42314792
88	PIK3CG	0.40609786
89	PBK	0.38324620
90	FER	0.37165181
91	CSNK2A2	0.35332268
92	PIM2	0.35188343
93	ABL1	0.34045641
94	NEK9	0.33824063
95	PRKCI	0.33197990
96	EIF2AK2	0.32888978
97	PRKACA	0.32409389
98	CSNK1G2	0.32258928
99	MST4	0.32200496
100	MAPKAPK5	0.30259561

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.77852333
2	Proteasome_Homo sapiens_hsa03050	3.24534663
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.98110566
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.92079165
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.58081787
6	Sulfur metabolism_Homo sapiens_hsa00920	2.57222444
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.48523792
8	Allograft rejection_Homo sapiens_hsa05330	2.47862560
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.37581786
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.33377155
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.31463806
12	Parkinsons disease_Homo sapiens_hsa05012	2.30925788
13	Asthma_Homo sapiens_hsa05310	2.21794223
14	Graft-versus-host disease_Homo sapiens_hsa05332	2.18543492
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83156943
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77983100
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.73354222
18	Basal transcription factors_Homo sapiens_hsa03022	1.71751591
19	Protein export_Homo sapiens_hsa03060	1.70327006
20	Sulfur relay system_Homo sapiens_hsa04122	1.64712929
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62796890
22	Alzheimers disease_Homo sapiens_hsa05010	1.60380128
23	Fat digestion and absorption_Homo sapiens_hsa04975	1.57609085
24	Ribosome_Homo sapiens_hsa03010	1.56837722
25	Caffeine metabolism_Homo sapiens_hsa00232	1.55217861
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.52990742
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.52884553
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.45936346
29	Folate biosynthesis_Homo sapiens_hsa00790	1.33458389
30	Huntingtons disease_Homo sapiens_hsa05016	1.31962415
31	One carbon pool by folate_Homo sapiens_hsa00670	1.30983865
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.30331734
33	Phototransduction_Homo sapiens_hsa04744	1.29644867
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.25864291
35	Fatty acid elongation_Homo sapiens_hsa00062	1.25134529
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22084305
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21835496
38	RNA polymerase_Homo sapiens_hsa03020	1.17482812
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16661501
40	Retinol metabolism_Homo sapiens_hsa00830	1.15133229
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.12595200
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09773838
43	Renin-angiotensin system_Homo sapiens_hsa04614	1.09205126
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07804632
45	Homologous recombination_Homo sapiens_hsa03440	1.07310930
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06640935
47	Mineral absorption_Homo sapiens_hsa04978	1.06065365
48	Butanoate metabolism_Homo sapiens_hsa00650	0.96301859
49	Circadian rhythm_Homo sapiens_hsa04710	0.94824088
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90340336
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90033299
52	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89584629
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89450603
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.89357292
55	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.84457471
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81081457
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80809679
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.77800303
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76963327
60	Base excision repair_Homo sapiens_hsa03410	0.76442392
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.75897876
62	Peroxisome_Homo sapiens_hsa04146	0.75132653
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74558380
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74450550
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.69342053
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.67303868
67	RNA degradation_Homo sapiens_hsa03018	0.61365542
68	Glutathione metabolism_Homo sapiens_hsa00480	0.60159044
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.59826347
70	Viral myocarditis_Homo sapiens_hsa05416	0.59657575
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57288681
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56532989
73	Purine metabolism_Homo sapiens_hsa00230	0.55249634
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52390213
75	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.50336767
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46224433
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45801283
78	Olfactory transduction_Homo sapiens_hsa04740	0.43948381
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43247287
80	Metabolic pathways_Homo sapiens_hsa01100	0.42070312
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41359535
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.39091469
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36949428
84	Herpes simplex infection_Homo sapiens_hsa05168	0.36418444
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34315123
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.32713839
87	Propanoate metabolism_Homo sapiens_hsa00640	0.32293980
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28435161
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27821007
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25802304
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.24764596
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.24646577
93	Taste transduction_Homo sapiens_hsa04742	0.24606270
94	PPAR signaling pathway_Homo sapiens_hsa03320	0.24372270
95	Pancreatic secretion_Homo sapiens_hsa04972	0.23626364
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.23187423
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.23017358
98	Pertussis_Homo sapiens_hsa05133	0.22936273
99	Fatty acid degradation_Homo sapiens_hsa00071	0.22824439
100	Salivary secretion_Homo sapiens_hsa04970	0.22228539

MYL6P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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