MYL6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)6.26361509
2cytidine catabolic process (GO:0006216)6.26361509
3cytidine deamination (GO:0009972)6.26361509
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.71072906
5sequestering of actin monomers (GO:0042989)5.52646871
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.34830646
7ATP synthesis coupled proton transport (GO:0015986)5.25267674
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.25267674
9DNA deamination (GO:0045006)5.24406556
10eosinophil chemotaxis (GO:0048245)4.98716122
11protein maturation by protein folding (GO:0022417)4.70602802
12eosinophil migration (GO:0072677)4.47264477
13platelet dense granule organization (GO:0060155)4.42705990
14proteasome assembly (GO:0043248)4.30476558
15protein neddylation (GO:0045116)4.26593988
16response to gravity (GO:0009629)4.22329558
17respiratory electron transport chain (GO:0022904)4.17511586
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.15157984
19electron transport chain (GO:0022900)4.12894384
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07397681
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.91171595
22detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.86129969
23positive regulation of actin filament depolymerization (GO:0030836)3.83507599
24protein complex biogenesis (GO:0070271)3.82660319
25chaperone mediated protein folding requiring cofactor (GO:0051085)3.65203379
26negative regulation of calcium ion transport into cytosol (GO:0010523)3.63683320
27regulation of cellular amino acid metabolic process (GO:0006521)3.56198819
28water-soluble vitamin biosynthetic process (GO:0042364)3.55966082
29positive regulation of interleukin-8 secretion (GO:2000484)3.52515918
30cell morphogenesis involved in neuron differentiation (GO:0048667)3.50922034
31negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47358929
32mitochondrial respiratory chain complex assembly (GO:0033108)3.44702725
33chaperone-mediated protein transport (GO:0072321)3.44005989
34GDP-mannose metabolic process (GO:0019673)3.42806829
35pyrimidine nucleoside catabolic process (GO:0046135)3.42488211
36response to interferon-beta (GO:0035456)3.40320012
37cellular response to zinc ion (GO:0071294)3.39674260
38macrophage chemotaxis (GO:0048246)3.33824776
39negative regulation by host of viral transcription (GO:0043922)3.29499786
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29360408
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.29247950
42NADH dehydrogenase complex assembly (GO:0010257)3.29247950
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29247950
44detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.24948547
45post-embryonic morphogenesis (GO:0009886)3.24782693
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21731465
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15333678
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.15155709
49termination of RNA polymerase III transcription (GO:0006386)3.15155709
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11626320
51establishment of viral latency (GO:0019043)3.09416807
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09073141
53negative regulation of T cell differentiation in thymus (GO:0033085)3.05792207
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00428978
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00157986
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00157986
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99940052
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99940052
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99940052
60negative regulation of ligase activity (GO:0051352)2.99880725
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99880725
62hydrogen ion transmembrane transport (GO:1902600)2.97506297
63GTP biosynthetic process (GO:0006183)2.96970738
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95109067
65type B pancreatic cell proliferation (GO:0044342)2.94806277
66ATP biosynthetic process (GO:0006754)2.94521171
67metallo-sulfur cluster assembly (GO:0031163)2.91479342
68iron-sulfur cluster assembly (GO:0016226)2.91479342
69mannosylation (GO:0097502)2.91449663
70extracellular fibril organization (GO:0043206)2.91006768
71regulation of dopamine metabolic process (GO:0042053)2.88644392
72regulation of catecholamine metabolic process (GO:0042069)2.88644392
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86759218
74regulation of cellular amine metabolic process (GO:0033238)2.86460770
75dopaminergic neuron differentiation (GO:0071542)2.86023961
76proton transport (GO:0015992)2.85976946
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85705989
78deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82762193
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.80800823
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80800823
81hydrogen transport (GO:0006818)2.80575927
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80033789
83L-fucose catabolic process (GO:0042355)2.79309887
84fucose catabolic process (GO:0019317)2.79309887
85L-fucose metabolic process (GO:0042354)2.79309887
86regulation of autophagic vacuole assembly (GO:2000785)2.78970802
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77709304
88signal transduction involved in cell cycle checkpoint (GO:0072395)2.76261670
89actin nucleation (GO:0045010)2.75485063
90ribosomal small subunit assembly (GO:0000028)2.73310408
91negative regulation of viral genome replication (GO:0045071)2.70785855
92establishment of integrated proviral latency (GO:0075713)2.67809867
93morphogenesis of an endothelium (GO:0003159)2.66533972
94endothelial tube morphogenesis (GO:0061154)2.66533972
95positive regulation of defense response to virus by host (GO:0002230)2.63064576
96L-ascorbic acid metabolic process (GO:0019852)2.61072576
97antigen processing and presentation of endogenous antigen (GO:0019883)2.60027860
98fusion of sperm to egg plasma membrane (GO:0007342)2.60017958
99negative regulation of gene silencing (GO:0060969)2.59930018
100protein targeting to mitochondrion (GO:0006626)2.57643671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.67859746
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.05149463
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73526134
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.53529371
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41614914
6VDR_22108803_ChIP-Seq_LS180_Human3.40338269
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19521802
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.14286540
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93781443
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91013748
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.75097632
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53340786
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.45582649
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34463679
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.19580487
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.18369583
17VDR_23849224_ChIP-Seq_CD4+_Human2.14714451
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07434502
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04427771
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03126465
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93751023
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88392531
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84379995
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.79026805
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.74092640
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72671259
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66945135
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61026816
29ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54832041
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.54672323
31BCL6_27268052_Chip-Seq_Bcells_Human1.50876246
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48804462
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47736525
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47537435
35PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.45838432
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44925619
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.43544451
38DCP1A_22483619_ChIP-Seq_HELA_Human1.37977082
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37535671
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37289079
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35671817
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35438421
43CTCF_18555785_ChIP-Seq_MESCs_Mouse1.34414891
44ELK1_19687146_ChIP-ChIP_HELA_Human1.26985269
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24810862
46CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23995457
47AR_20517297_ChIP-Seq_VCAP_Human1.23444026
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22978100
49NANOG_20526341_ChIP-Seq_ESCs_Human1.21133730
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20983108
51FOXP3_21729870_ChIP-Seq_TREG_Human1.20887702
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.18841359
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18841359
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16949513
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14969403
56MYC_19829295_ChIP-Seq_ESCs_Human1.10824741
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10443025
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10203565
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09925173
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09904108
61MYC_18940864_ChIP-ChIP_HL60_Human1.05109688
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05071317
63STAT1_20625510_ChIP-Seq_HELA_Human1.04794504
64GATA3_26560356_Chip-Seq_TH2_Human1.04709382
65CTCF_20526341_ChIP-Seq_ESCs_Human1.04468906
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04305644
67BCOR_27268052_Chip-Seq_Bcells_Human1.04279178
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02555761
69E2F1_20622854_ChIP-Seq_HELA_Human1.02438807
70ERA_21632823_ChIP-Seq_H3396_Human1.01769820
71P300_27268052_Chip-Seq_Bcells_Human1.01701391
72MYB_26560356_Chip-Seq_TH2_Human1.01074323
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99878545
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99015045
75YY1_22570637_ChIP-Seq_MALME-3M_Human0.98688071
76HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97995482
77RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97830298
78SOX2_19829295_ChIP-Seq_ESCs_Human0.96824453
79NANOG_19829295_ChIP-Seq_ESCs_Human0.96824453
80GATA3_21878914_ChIP-Seq_MCF-7_Human0.96767761
81ERG_20517297_ChIP-Seq_VCAP_Human0.96730532
82TAF2_19829295_ChIP-Seq_ESCs_Human0.96115994
83CBP_21632823_ChIP-Seq_H3396_Human0.94929306
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94272537
85ZNF274_21170338_ChIP-Seq_K562_Hela0.94069916
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93274721
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92943733
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92801091
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91746332
90TP53_22573176_ChIP-Seq_HFKS_Human0.91388093
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.90167275
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.90035944
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89892672
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88959150
95GABP_19822575_ChIP-Seq_HepG2_Human0.88788798
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87550123
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83564759
98NCOR_22424771_ChIP-Seq_293T_Human0.81932118
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.81367348
100HTT_18923047_ChIP-ChIP_STHdh_Human0.81306165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.56901006
2MP0006072_abnormal_retinal_apoptosis3.44879674
3MP0004147_increased_porphyrin_level3.31044675
4MP0004145_abnormal_muscle_electrophysio2.91976373
5MP0003806_abnormal_nucleotide_metabolis2.71998647
6MP0005257_abnormal_intraocular_pressure2.71569912
7MP0005360_urolithiasis2.63687842
8MP0001905_abnormal_dopamine_level2.44457667
9MP0005165_increased_susceptibility_to2.36508850
10MP0009333_abnormal_splenocyte_physiolog2.25761819
11MP0003011_delayed_dark_adaptation2.11923757
12MP0005387_immune_system_phenotype2.11686037
13MP0001790_abnormal_immune_system2.11686037
14MP0009785_altered_susceptibility_to1.94201135
15MP0001835_abnormal_antigen_presentation1.92333276
16MP0003638_abnormal_response/metabolism_1.91974168
17MP0000372_irregular_coat_pigmentation1.86844323
18MP0003075_altered_response_to1.82518091
19MP0004742_abnormal_vestibular_system1.77345448
20MP0002095_abnormal_skin_pigmentation1.73344918
21MP0002148_abnormal_hypersensitivity_rea1.69021293
22MP0000749_muscle_degeneration1.60993316
23MP0005025_abnormal_response_to1.56039668
24MP0005253_abnormal_eye_physiology1.55889718
25MP0000685_abnormal_immune_system1.54316325
26MP0008004_abnormal_stomach_pH1.53031103
27MP0005645_abnormal_hypothalamus_physiol1.51950336
28MP0003786_premature_aging1.47506694
29MP0003646_muscle_fatigue1.46582658
30MP0000516_abnormal_urinary_system1.46205038
31MP0005367_renal/urinary_system_phenotyp1.46205038
32MP0003866_abnormal_defecation1.45796274
33MP0005085_abnormal_gallbladder_physiolo1.45528526
34MP0003045_fibrosis1.44738601
35MP0002876_abnormal_thyroid_physiology1.43995674
36MP0002138_abnormal_hepatobiliary_system1.39110825
37MP0009745_abnormal_behavioral_response1.35637796
38MP0008775_abnormal_heart_ventricle1.34372922
39MP0002723_abnormal_immune_serum1.34028894
40MP0001800_abnormal_humoral_immune1.33933334
41MP0004043_abnormal_pH_regulation1.33468082
42MP0001879_abnormal_lymphatic_vessel1.33305536
43MP0004510_myositis1.31858689
44MP0002638_abnormal_pupillary_reflex1.31172311
45MP0002420_abnormal_adaptive_immunity1.28080253
46MP0006082_CNS_inflammation1.25814636
47MP0005584_abnormal_enzyme/coenzyme_acti1.24868204
48MP0001764_abnormal_homeostasis1.23681338
49MP0001819_abnormal_immune_cell1.22580643
50MP0002102_abnormal_ear_morphology1.20460519
51MP0003186_abnormal_redox_activity1.20454143
52MP0008875_abnormal_xenobiotic_pharmacok1.19796444
53MP0005083_abnormal_biliary_tract1.17751404
54MP0006036_abnormal_mitochondrial_physio1.17092133
55MP0002877_abnormal_melanocyte_morpholog1.15239603
56MP0002277_abnormal_respiratory_mucosa1.10913348
57MP0002332_abnormal_exercise_endurance1.09833483
58MP0005464_abnormal_platelet_physiology1.09497605
59MP0000343_altered_response_to1.06452677
60MP0002452_abnormal_antigen_presenting1.06389264
61MP0005166_decreased_susceptibility_to1.05810068
62MP0001542_abnormal_bone_strength1.05100436
63MP0001873_stomach_inflammation1.03192516
64MP0005377_hearing/vestibular/ear_phenot1.02953971
65MP0003878_abnormal_ear_physiology1.02953971
66MP0005551_abnormal_eye_electrophysiolog1.01706680
67MP0001845_abnormal_inflammatory_respons1.01258275
68MP0003718_maternal_effect1.01095397
69MP0003693_abnormal_embryo_hatching0.99265458
70MP0003136_yellow_coat_color0.99201470
71MP0001293_anophthalmia0.99172350
72MP0000647_abnormal_sebaceous_gland0.98982404
73MP0001666_abnormal_nutrient_absorption0.98873477
74MP0005075_abnormal_melanosome_morpholog0.96878644
75MP0005332_abnormal_amino_acid0.96304052
76MP0003195_calcinosis0.96034356
77MP0003315_abnormal_perineum_morphology0.95026522
78MP0009764_decreased_sensitivity_to0.91800592
79MP0005365_abnormal_bile_salt0.90484119
80MP0003950_abnormal_plasma_membrane0.90262653
81MP0001485_abnormal_pinna_reflex0.90057423
82MP0002163_abnormal_gland_morphology0.87380913
83MP0000716_abnormal_immune_system0.86371965
84MP0005620_abnormal_muscle_contractility0.86296070
85MP0002972_abnormal_cardiac_muscle0.86145794
86MP0005084_abnormal_gallbladder_morpholo0.85861378
87MP0000566_synostosis0.85405672
88MP0002295_abnormal_pulmonary_circulatio0.84567288
89MP0002837_dystrophic_cardiac_calcinosis0.82743575
90MP0000427_abnormal_hair_cycle0.81218088
91MP0000858_altered_metastatic_potential0.80545590
92MP0002733_abnormal_thermal_nociception0.80475893
93MP0003880_abnormal_central_pattern0.79494436
94MP0008469_abnormal_protein_level0.79214418
95MP0005000_abnormal_immune_tolerance0.78886864
96MP0002067_abnormal_sensory_capabilities0.78821612
97MP0010155_abnormal_intestine_physiology0.78400296
98MP0005636_abnormal_mineral_homeostasis0.78252802
99MP0002938_white_spotting0.77734167
100MP0000465_gastrointestinal_hemorrhage0.75773861

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.98006323
2Mitochondrial inheritance (HP:0001427)4.46986736
3Acute necrotizing encephalopathy (HP:0006965)4.42589039
4Abnormal mitochondria in muscle tissue (HP:0008316)4.19381090
5Delayed CNS myelination (HP:0002188)4.11907759
6Hepatocellular necrosis (HP:0001404)3.90740568
7Hepatic necrosis (HP:0002605)3.77528713
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.75143243
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.75143243
10Increased CSF lactate (HP:0002490)3.66035641
11Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65963657
12Progressive macrocephaly (HP:0004481)3.52571449
13Increased intramyocellular lipid droplets (HP:0012240)3.51183180
14Acute encephalopathy (HP:0006846)3.50745827
15Glucose intolerance (HP:0000833)3.35245877
16Type I transferrin isoform profile (HP:0003642)3.29139356
17IgG deficiency (HP:0004315)3.26460047
18Agammaglobulinemia (HP:0004432)3.16037312
19Chronic sinusitis (HP:0011109)3.13093488
20Exercise intolerance (HP:0003546)3.06601948
21Aplastic anemia (HP:0001915)2.99918953
22Congenital, generalized hypertrichosis (HP:0004540)2.93833064
23Increased muscle lipid content (HP:0009058)2.92772515
24Reduced antithrombin III activity (HP:0001976)2.92003941
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90640003
26Nausea (HP:0002018)2.87784631
27Increased hepatocellular lipid droplets (HP:0006565)2.81458577
28Cerebral edema (HP:0002181)2.74460611
29Elevated erythrocyte sedimentation rate (HP:0003565)2.72402788
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71075779
31Abnormal protein N-linked glycosylation (HP:0012347)2.71075779
32Abnormal protein glycosylation (HP:0012346)2.71075779
33Abnormal glycosylation (HP:0012345)2.71075779
34Renal Fanconi syndrome (HP:0001994)2.70708976
35Methylmalonic aciduria (HP:0012120)2.70457079
36Reduced subcutaneous adipose tissue (HP:0003758)2.69945137
37Abnormality of binocular vision (HP:0011514)2.67829695
38Diplopia (HP:0000651)2.67829695
39Abnormal glucose tolerance (HP:0001952)2.62438492
40Down-sloping shoulders (HP:0200021)2.60483684
41Recurrent bronchitis (HP:0002837)2.58416280
42Palpitations (HP:0001962)2.55413307
433-Methylglutaconic aciduria (HP:0003535)2.54939794
44Increased IgM level (HP:0003496)2.52881857
45Lipid accumulation in hepatocytes (HP:0006561)2.46281227
46Increased serum lactate (HP:0002151)2.45326069
47Lactic acidosis (HP:0003128)2.45229731
48Dicarboxylic aciduria (HP:0003215)2.39862428
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39862428
50Methylmalonic acidemia (HP:0002912)2.38972103
51Prostate neoplasm (HP:0100787)2.36953185
52Abnormality of the prostate (HP:0008775)2.36079834
53IgM deficiency (HP:0002850)2.31900480
54Malnutrition (HP:0004395)2.31657547
55Palpebral edema (HP:0100540)2.30676776
56Exertional dyspnea (HP:0002875)2.30473334
57Torticollis (HP:0000473)2.29669017
58Respiratory failure (HP:0002878)2.23569467
59Pancytopenia (HP:0001876)2.21950572
60Adrenal hypoplasia (HP:0000835)2.20971632
61Opisthotonus (HP:0002179)2.16969225
62Proximal tubulopathy (HP:0000114)2.16076708
63Glycosuria (HP:0003076)2.11548316
64Abnormality of urine glucose concentration (HP:0011016)2.11548316
65Optic disc pallor (HP:0000543)2.06324779
66Large for gestational age (HP:0001520)2.05201683
67Axonal loss (HP:0003447)2.02942826
68Lethargy (HP:0001254)2.02197002
69Generalized aminoaciduria (HP:0002909)2.01777932
70Abnormal spermatogenesis (HP:0008669)1.99565344
71Late onset (HP:0003584)1.98262258
72Abnormality of T cell number (HP:0011839)1.98037999
73Renal cortical cysts (HP:0000803)1.97491927
74Skin rash (HP:0000988)1.97426854
75T lymphocytopenia (HP:0005403)1.97242528
76Depressed nasal tip (HP:0000437)1.95014130
77Supernumerary spleens (HP:0009799)1.91140564
78Poor speech (HP:0002465)1.90761821
79Rhabdomyolysis (HP:0003201)1.88101642
80Rough bone trabeculation (HP:0100670)1.87850396
81Abnormality of the vitamin B12 metabolism (HP:0004341)1.87674354
82Testicular atrophy (HP:0000029)1.87650224
83Sparse eyelashes (HP:0000653)1.86257808
84Craniofacial dystonia (HP:0012179)1.85837342
85Tongue fasciculations (HP:0001308)1.85736277
86Hypoproteinemia (HP:0003075)1.85566742
87Hypoplasia of the uterus (HP:0000013)1.84638325
88Abnormality of vitamin B metabolism (HP:0004340)1.81936405
89Aplasia/hypoplasia of the uterus (HP:0008684)1.80229909
90Confusion (HP:0001289)1.78773400
91Hypokinesia (HP:0002375)1.78111928
92Hyperglycinemia (HP:0002154)1.77324652
93Oral leukoplakia (HP:0002745)1.73921458
94Cerebral palsy (HP:0100021)1.73166656
95Progressive external ophthalmoplegia (HP:0000590)1.71838177
96Postural tremor (HP:0002174)1.71672455
97IgA deficiency (HP:0002720)1.70657458
98Amyloidosis (HP:0011034)1.70591468
99Vascular calcification (HP:0004934)1.70010583
100Focal dystonia (HP:0004373)1.66976148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.47056632
2GRK13.21315080
3LIMK13.17961939
4TESK13.11962050
5KDR2.44293640
6TESK211.5080717
7NME21.89979749
8TXK1.87722535
9STK161.83756122
10PHKG11.78759315
11PHKG21.78759315
12MAP3K121.69608685
13MST41.63698733
14MAPKAPK31.54958642
15SRPK11.46642150
16DAPK11.42442144
17BCKDK1.40365817
18WNK31.38477711
19SIK31.35038441
20EPHA21.34914442
21BUB11.26451835
22MAP4K21.16462931
23SIK21.15862979
24MYLK1.14773351
25VRK11.14326315
26DYRK21.12899255
27ADRBK21.10988692
28ABL21.05982714
29TLK11.05504948
30EPHB21.01878018
31ARAF0.98952848
32ZAK0.94697801
33MAP3K100.93961729
34LMTK20.93110303
35MAP2K70.85806262
36PIM20.84797928
37CCNB10.83948683
38MARK10.82180271
39ILK0.80574810
40ITK0.78021071
41NUAK10.76703562
42RPS6KA40.73767420
43MAP3K110.71323918
44PTK2B0.68374480
45PDK20.66694050
46SCYL20.65297548
47NME10.59699035
48EIF2AK10.57452744
49TAF10.56435878
50DAPK20.54033757
51CDK190.52760820
52LRRK20.48201346
53SYK0.47350864
54CSNK1G30.43342692
55TBK10.43171773
56PAK40.42497602
57ADRBK10.42481110
58PRKCI0.41275158
59OBSCN0.41103579
60IKBKE0.40959767
61MAPK130.39485496
62CAMK2G0.38358545
63CASK0.38186587
64MARK30.37752116
65CDK80.37072423
66BMPR20.36945378
67EIF2AK30.35819993
68AURKA0.35324982
69BMPR1B0.34867212
70DAPK30.34028132
71RPS6KA50.34000925
72GRK50.31854101
73GSK3A0.30063039
74ROCK10.29437157
75EPHA40.29006113
76PRKCQ0.28808050
77PIK3CA0.28247004
78CSNK1G20.27947150
79LYN0.27711785
80PINK10.26753354
81KIT0.26506971
82IKBKB0.26187639
83MAP4K10.25867675
84CAMK2A0.25738516
85GRK70.25430138
86MOS0.24603697
87SIK10.23935499
88CSNK1A1L0.23615153
89INSRR0.22593656
90STK100.22374217
91PRKACA0.21845370
92IGF1R0.21290316
93CLK10.21066462
94CSK0.20558634
95CSNK1G10.20505238
96CAMK2D0.20483467
97CSNK2A10.19851387
98ERBB40.19440868
99MUSK0.18215447
100FYN0.17571567

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.45575611
2Oxidative phosphorylation_Homo sapiens_hsa001904.16606579
3Parkinsons disease_Homo sapiens_hsa050123.75345980
4Ribosome_Homo sapiens_hsa030102.70141579
5Alzheimers disease_Homo sapiens_hsa050102.57774310
6Folate biosynthesis_Homo sapiens_hsa007902.56188327
7Primary immunodeficiency_Homo sapiens_hsa053402.39949435
8Huntingtons disease_Homo sapiens_hsa050162.31946767
9Protein export_Homo sapiens_hsa030602.22275916
10Cardiac muscle contraction_Homo sapiens_hsa042602.17231995
11Sulfur relay system_Homo sapiens_hsa041222.15428805
12Graft-versus-host disease_Homo sapiens_hsa053322.08009502
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07669142
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06895007
15Phototransduction_Homo sapiens_hsa047442.04565078
16Antigen processing and presentation_Homo sapiens_hsa046122.03859974
17Allograft rejection_Homo sapiens_hsa053302.02594596
18Autoimmune thyroid disease_Homo sapiens_hsa053201.95266412
19RNA polymerase_Homo sapiens_hsa030201.93432773
20Asthma_Homo sapiens_hsa053101.88880467
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.88059502
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.70313798
23Type I diabetes mellitus_Homo sapiens_hsa049401.67247410
24Glutathione metabolism_Homo sapiens_hsa004801.63908480
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.48071291
26Pyrimidine metabolism_Homo sapiens_hsa002401.47576727
27Sulfur metabolism_Homo sapiens_hsa009201.33552554
28Rheumatoid arthritis_Homo sapiens_hsa053231.30723810
29Peroxisome_Homo sapiens_hsa041461.22463526
30Salivary secretion_Homo sapiens_hsa049701.20263172
31Hematopoietic cell lineage_Homo sapiens_hsa046401.18389906
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16672075
33Purine metabolism_Homo sapiens_hsa002301.11675050
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06252928
35Viral myocarditis_Homo sapiens_hsa054161.04869269
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03247015
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01860746
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00737622
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98394303
40Fatty acid elongation_Homo sapiens_hsa000620.96505826
41Nitrogen metabolism_Homo sapiens_hsa009100.94599877
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86996919
43Arachidonic acid metabolism_Homo sapiens_hsa005900.86117544
44Chemical carcinogenesis_Homo sapiens_hsa052040.85184676
45Steroid biosynthesis_Homo sapiens_hsa001000.85151104
46Linoleic acid metabolism_Homo sapiens_hsa005910.84138317
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82563857
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81464149
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80779153
50Galactose metabolism_Homo sapiens_hsa000520.77255479
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76339295
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75774809
53Base excision repair_Homo sapiens_hsa034100.75527065
54Mismatch repair_Homo sapiens_hsa034300.74223565
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.73475583
56Retinol metabolism_Homo sapiens_hsa008300.73353293
57N-Glycan biosynthesis_Homo sapiens_hsa005100.72039979
58Metabolic pathways_Homo sapiens_hsa011000.70701137
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66529569
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65371679
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62734014
62Salmonella infection_Homo sapiens_hsa051320.62598234
63Mineral absorption_Homo sapiens_hsa049780.62070834
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61904322
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.58982699
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58110115
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56159283
68Homologous recombination_Homo sapiens_hsa034400.55248864
69Vitamin digestion and absorption_Homo sapiens_hsa049770.53976572
70Nucleotide excision repair_Homo sapiens_hsa034200.53353275
71Fructose and mannose metabolism_Homo sapiens_hsa000510.52891368
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50333239
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.49470844
74Pyruvate metabolism_Homo sapiens_hsa006200.48898490
75Collecting duct acid secretion_Homo sapiens_hsa049660.46929515
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46160641
77Fat digestion and absorption_Homo sapiens_hsa049750.44875131
78Propanoate metabolism_Homo sapiens_hsa006400.43116386
79Renin-angiotensin system_Homo sapiens_hsa046140.41626747
80Morphine addiction_Homo sapiens_hsa050320.41116335
81Carbon metabolism_Homo sapiens_hsa012000.38549585
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37792733
83Caffeine metabolism_Homo sapiens_hsa002320.36065221
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34833386
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33871394
86Shigellosis_Homo sapiens_hsa051310.33828227
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32996242
88DNA replication_Homo sapiens_hsa030300.32802784
89Vibrio cholerae infection_Homo sapiens_hsa051100.31624091
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28125895
91RNA degradation_Homo sapiens_hsa030180.28006335
92Starch and sucrose metabolism_Homo sapiens_hsa005000.26609178
93Regulation of autophagy_Homo sapiens_hsa041400.26579658
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.26323746
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25769885
96Ether lipid metabolism_Homo sapiens_hsa005650.22129906
97Epstein-Barr virus infection_Homo sapiens_hsa051690.19589198
98Endocytosis_Homo sapiens_hsa041440.18880240
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18381793
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17538615

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