MYL6P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.02293019
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98171354
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86337957
4ATP synthesis coupled proton transport (GO:0015986)4.86337957
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.42580149
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.29312658
7DNA deamination (GO:0045006)4.14730256
8GTP biosynthetic process (GO:0006183)4.08985281
9cytidine metabolic process (GO:0046087)3.87794491
10cytidine catabolic process (GO:0006216)3.87794491
11cytidine deamination (GO:0009972)3.87794491
12GPI anchor metabolic process (GO:0006505)3.75852736
13histamine transport (GO:0051608)3.63888890
14terpenoid biosynthetic process (GO:0016114)3.61739180
15preassembly of GPI anchor in ER membrane (GO:0016254)3.58274543
16positive regulation of prostaglandin secretion (GO:0032308)3.49034664
17neurotransmitter catabolic process (GO:0042135)3.44930672
18pyrimidine ribonucleoside catabolic process (GO:0046133)3.42790158
19sequestering of actin monomers (GO:0042989)3.39699426
20GPI anchor biosynthetic process (GO:0006506)3.39611217
21regulation of prostaglandin secretion (GO:0032306)3.39569415
22water-soluble vitamin biosynthetic process (GO:0042364)3.38332510
23protein complex biogenesis (GO:0070271)3.37854710
24regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.36969501
25regulation of mesoderm development (GO:2000380)3.35946848
26T cell apoptotic process (GO:0070231)3.35135207
27UTP biosynthetic process (GO:0006228)3.27106465
28regulation of cellular amino acid metabolic process (GO:0006521)3.26982508
29chaperone-mediated protein transport (GO:0072321)3.25064653
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22254206
31electron transport chain (GO:0022900)3.21206312
32protein neddylation (GO:0045116)3.20320210
33positive regulation of amino acid transport (GO:0051957)3.19782652
34behavioral response to nicotine (GO:0035095)3.19718744
35negative regulation of telomere maintenance (GO:0032205)3.18386916
36mitochondrial respiratory chain complex assembly (GO:0033108)3.18220120
37respiratory electron transport chain (GO:0022904)3.18037993
38peptidyl-histidine modification (GO:0018202)3.17494518
39mannosylation (GO:0097502)3.17228234
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15549541
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07696068
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07696068
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07326245
44cullin deneddylation (GO:0010388)3.06176504
45mitochondrial DNA replication (GO:0006264)3.05869277
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05434199
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05434199
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05434199
49rRNA modification (GO:0000154)3.03959173
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03509736
51negative regulation of T cell differentiation in thymus (GO:0033085)3.03221533
52lymphocyte apoptotic process (GO:0070227)3.03031768
53hydrogen ion transmembrane transport (GO:1902600)3.00769365
54negative regulation of calcium ion transport into cytosol (GO:0010523)3.00339427
55UTP metabolic process (GO:0046051)2.99847241
56negative regulation by host of viral transcription (GO:0043922)2.97273040
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96526793
58mitochondrial respiratory chain complex I assembly (GO:0032981)2.95482692
59NADH dehydrogenase complex assembly (GO:0010257)2.95482692
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95482692
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95020623
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95020623
63purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93840055
64proton transport (GO:0015992)2.93806350
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93685972
66positive regulation of calcium-mediated signaling (GO:0050850)2.92861567
67hydrogen transport (GO:0006818)2.89496960
68signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89284566
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.89284566
70positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.89021251
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85347370
72protein deneddylation (GO:0000338)2.85095713
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.83987776
74regulation of T cell receptor signaling pathway (GO:0050856)2.83241379
75response to pheromone (GO:0019236)2.83068340
76platelet dense granule organization (GO:0060155)2.81062877
77DNA strand renaturation (GO:0000733)2.79372570
78organelle membrane fusion (GO:0090174)2.78239115
79CTP metabolic process (GO:0046036)2.76506213
80CTP biosynthetic process (GO:0006241)2.76506213
81negative regulation of ligase activity (GO:0051352)2.75904360
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75904360
83gonadal mesoderm development (GO:0007506)2.74159074
84fucose catabolic process (GO:0019317)2.72283810
85L-fucose metabolic process (GO:0042354)2.72283810
86L-fucose catabolic process (GO:0042355)2.72283810
87termination of RNA polymerase III transcription (GO:0006386)2.72241830
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.72241830
89histamine secretion (GO:0001821)2.71708492
90positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68791713
91ER overload response (GO:0006983)2.67748596
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66689624
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62582220
94positive regulation of organic acid transport (GO:0032892)2.61519377
95ATP biosynthetic process (GO:0006754)2.61013587
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60880669
97positive regulation of fatty acid beta-oxidation (GO:0032000)2.60411686
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60231490
99protein peptidyl-prolyl isomerization (GO:0000413)2.58409142
100artery smooth muscle contraction (GO:0014824)2.57863750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.23791627
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02051467
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.66307202
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48695136
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.42603866
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15563692
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.98448079
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.66022300
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.64987072
10VDR_22108803_ChIP-Seq_LS180_Human2.49132878
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45390171
12ZNF274_21170338_ChIP-Seq_K562_Hela2.44017089
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.26998142
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13197042
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07588258
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.04041596
17ELK1_19687146_ChIP-ChIP_HELA_Human1.91401530
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88655286
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.88428769
20VDR_23849224_ChIP-Seq_CD4+_Human1.84885388
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71682769
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.70246163
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.64676527
24EWS_26573619_Chip-Seq_HEK293_Human1.62500086
25AR_20517297_ChIP-Seq_VCAP_Human1.59985212
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59321633
27BCAT_22108803_ChIP-Seq_LS180_Human1.58241101
28GBX2_23144817_ChIP-Seq_PC3_Human1.55871183
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51017121
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50040478
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49907107
32MYC_18940864_ChIP-ChIP_HL60_Human1.49279695
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47889376
34SOX2_19829295_ChIP-Seq_ESCs_Human1.47089611
35NANOG_19829295_ChIP-Seq_ESCs_Human1.47089611
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.46015476
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44631992
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41640468
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40417873
40IGF1R_20145208_ChIP-Seq_DFB_Human1.38103336
41IRF1_19129219_ChIP-ChIP_H3396_Human1.37079582
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36446908
43P300_19829295_ChIP-Seq_ESCs_Human1.35675485
44FOXP3_21729870_ChIP-Seq_TREG_Human1.34442610
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34261257
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31394749
47TAF15_26573619_Chip-Seq_HEK293_Human1.27249869
48TP53_22573176_ChIP-Seq_HFKS_Human1.26354542
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25675671
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25238291
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.24294669
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24294669
53ER_23166858_ChIP-Seq_MCF-7_Human1.23432551
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22475615
55HTT_18923047_ChIP-ChIP_STHdh_Human1.20538618
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20365651
57FUS_26573619_Chip-Seq_HEK293_Human1.19521271
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18059300
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18056263
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.17758729
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17177902
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16764459
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.15943223
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13169505
65GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.12713154
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11340154
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.10656541
68TAF2_19829295_ChIP-Seq_ESCs_Human1.09812240
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07378826
70NANOG_20526341_ChIP-Seq_ESCs_Human1.06529980
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04920379
72GATA3_26560356_Chip-Seq_TH2_Human1.02370941
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01500031
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00600122
75NCOR_22424771_ChIP-Seq_293T_Human1.00429454
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99909401
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.98904145
78ERA_21632823_ChIP-Seq_H3396_Human0.98811698
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98625277
80EED_16625203_ChIP-ChIP_MESCs_Mouse0.97270414
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94503188
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93198586
83ERG_20517297_ChIP-Seq_VCAP_Human0.92423474
84FOXH1_21741376_ChIP-Seq_ESCs_Human0.91744895
85TCF4_22108803_ChIP-Seq_LS180_Human0.91700601
86SMAD4_21741376_ChIP-Seq_EPCs_Human0.91252450
87STAT3_18555785_Chip-Seq_ESCs_Mouse0.90455012
88MYC_19829295_ChIP-Seq_ESCs_Human0.89575757
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89344613
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89323647
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87379429
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87283547
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85873052
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.85831237
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.85721066
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85426596
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.84638948
98DCP1A_22483619_ChIP-Seq_HELA_Human0.84368523
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82296497
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80796602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.04089551
2MP0010386_abnormal_urinary_bladder3.22675149
3MP0000372_irregular_coat_pigmentation3.21629453
4MP0005671_abnormal_response_to2.88470101
5MP0001835_abnormal_antigen_presentation2.87755094
6MP0002138_abnormal_hepatobiliary_system2.80498543
7MP0002163_abnormal_gland_morphology2.77007358
8MP0008875_abnormal_xenobiotic_pharmacok2.45626489
9MP0008872_abnormal_physiological_respon2.45087581
10MP0006035_abnormal_mitochondrial_morpho2.42123951
11MP0002234_abnormal_pharynx_morphology2.38327983
12MP0005075_abnormal_melanosome_morpholog2.34092800
13MP0002837_dystrophic_cardiac_calcinosis2.29977062
14MP0006036_abnormal_mitochondrial_physio2.25786795
15MP0001873_stomach_inflammation2.19911424
16MP0002736_abnormal_nociception_after2.17921551
17MP0002735_abnormal_chemical_nociception2.15927266
18MP0001968_abnormal_touch/_nociception2.09654609
19MP0006072_abnormal_retinal_apoptosis2.07037285
20MP0005084_abnormal_gallbladder_morpholo2.03350079
21MP0002102_abnormal_ear_morphology1.90760035
22MP0005408_hypopigmentation1.83335112
23MP0003195_calcinosis1.81207256
24MP0004145_abnormal_muscle_electrophysio1.77711495
25MP0005167_abnormal_blood-brain_barrier1.70678006
26MP0006082_CNS_inflammation1.68014564
27MP0003283_abnormal_digestive_organ1.62467827
28MP0004742_abnormal_vestibular_system1.58832590
29MP0003786_premature_aging1.56072877
30MP0004885_abnormal_endolymph1.50852442
31MP0001970_abnormal_pain_threshold1.46546746
32MP0002272_abnormal_nervous_system1.44805788
33MP0005379_endocrine/exocrine_gland_phen1.43869563
34MP0005551_abnormal_eye_electrophysiolog1.43445119
35MP0003878_abnormal_ear_physiology1.43377539
36MP0005377_hearing/vestibular/ear_phenot1.43377539
37MP0008775_abnormal_heart_ventricle1.42016368
38MP0005387_immune_system_phenotype1.40537281
39MP0001790_abnormal_immune_system1.40537281
40MP0002148_abnormal_hypersensitivity_rea1.39641802
41MP0002638_abnormal_pupillary_reflex1.38910023
42MP0003866_abnormal_defecation1.37287373
43MP0000685_abnormal_immune_system1.35965414
44MP0002938_white_spotting1.35661399
45MP0001800_abnormal_humoral_immune1.33142577
46MP0003763_abnormal_thymus_physiology1.30999116
47MP0006276_abnormal_autonomic_nervous1.24721963
48MP0009785_altered_susceptibility_to1.21304261
49MP0003950_abnormal_plasma_membrane1.20157513
50MP0003806_abnormal_nucleotide_metabolis1.19425048
51MP0004043_abnormal_pH_regulation1.19261350
52MP0001756_abnormal_urination1.18245311
53MP0004142_abnormal_muscle_tone1.16271850
54MP0003119_abnormal_digestive_system1.14963555
55MP0001986_abnormal_taste_sensitivity1.13850861
56MP0005085_abnormal_gallbladder_physiolo1.13793738
57MP0009745_abnormal_behavioral_response1.13207107
58MP0002452_abnormal_antigen_presenting1.13133035
59MP0001348_abnormal_lacrimal_gland1.12823074
60MP0004084_abnormal_cardiac_muscle1.09851627
61MP0009333_abnormal_splenocyte_physiolog1.08079671
62MP0002277_abnormal_respiratory_mucosa1.05408895
63MP0002733_abnormal_thermal_nociception1.02969917
64MP0005253_abnormal_eye_physiology1.00694330
65MP0002693_abnormal_pancreas_physiology0.98098159
66MP0002723_abnormal_immune_serum0.96438404
67MP0003011_delayed_dark_adaptation0.96081187
68MP0005365_abnormal_bile_salt0.94455037
69MP0005389_reproductive_system_phenotype0.92571306
70MP0001663_abnormal_digestive_system0.90533452
71MP0001819_abnormal_immune_cell0.89046844
72MP0001879_abnormal_lymphatic_vessel0.87491347
73MP0009643_abnormal_urine_homeostasis0.85449633
74MP0005670_abnormal_white_adipose0.85339033
75MP0004215_abnormal_myocardial_fiber0.85135529
76MP0005645_abnormal_hypothalamus_physiol0.82879610
77MP0000538_abnormal_urinary_bladder0.82582213
78MP0005646_abnormal_pituitary_gland0.82229777
79MP0009697_abnormal_copulation0.81307775
80MP0005000_abnormal_immune_tolerance0.80923230
81MP0003186_abnormal_redox_activity0.80599144
82MP0002734_abnormal_mechanical_nocicepti0.80422741
83MP0005360_urolithiasis0.77968261
84MP0002420_abnormal_adaptive_immunity0.76924754
85MP0001293_anophthalmia0.76717727
86MP0005410_abnormal_fertilization0.76599989
87MP0000230_abnormal_systemic_arterial0.74613758
88MP0001919_abnormal_reproductive_system0.73683003
89MP0000015_abnormal_ear_pigmentation0.73275515
90MP0002160_abnormal_reproductive_system0.72908305
91MP0005636_abnormal_mineral_homeostasis0.72583846
92MP0009046_muscle_twitch0.72214401
93MP0003136_yellow_coat_color0.71966242
94MP0000358_abnormal_cell_content/0.70188131
95MP0008873_increased_physiological_sensi0.68831997
96MP0002064_seizures0.65359868
97MP0003252_abnormal_bile_duct0.65282223
98MP0008058_abnormal_DNA_repair0.64378378
99MP0004381_abnormal_hair_follicle0.64346883
100MP0002557_abnormal_social/conspecific_i0.63640351

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.04437008
2Absent/shortened dynein arms (HP:0200106)4.50615238
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.50615238
4IgG deficiency (HP:0004315)3.87059054
5Congenital stationary night blindness (HP:0007642)3.64501691
6Decreased electroretinogram (ERG) amplitude (HP:0000654)3.43023381
7Ulnar claw (HP:0001178)3.35060630
8Colon cancer (HP:0003003)3.25942147
9Hypoproteinemia (HP:0003075)3.20944369
10Cerebral palsy (HP:0100021)3.08107034
11Stomatitis (HP:0010280)3.05887509
12Acute necrotizing encephalopathy (HP:0006965)2.98635038
13Abolished electroretinogram (ERG) (HP:0000550)2.98498083
14Mitochondrial inheritance (HP:0001427)2.94490144
15Abnormality of B cell number (HP:0010975)2.90283495
16Abnormal mitochondria in muscle tissue (HP:0008316)2.89708014
17B lymphocytopenia (HP:0010976)2.83295141
18Increased IgM level (HP:0003496)2.75936009
19Acute encephalopathy (HP:0006846)2.75558272
20Increased CSF lactate (HP:0002490)2.74028869
21Constricted visual fields (HP:0001133)2.72934478
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68616210
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68616210
24Abnormal respiratory epithelium morphology (HP:0012253)2.65689986
25Abnormal respiratory motile cilium morphology (HP:0005938)2.65689986
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.63088498
27Hypoplasia of the fovea (HP:0007750)2.63088498
28Parakeratosis (HP:0001036)2.61767098
29Hemoptysis (HP:0002105)2.57483746
30Joint swelling (HP:0001386)2.53787603
31Increased serum lactate (HP:0002151)2.52387775
32Large for gestational age (HP:0001520)2.52056988
33Hepatocellular necrosis (HP:0001404)2.47578847
34Pancreatic cysts (HP:0001737)2.47554899
35Abnormal ciliary motility (HP:0012262)2.46764877
36Elevated erythrocyte sedimentation rate (HP:0003565)2.45952672
37Arthropathy (HP:0003040)2.41197881
38Increased hepatocellular lipid droplets (HP:0006565)2.36514839
39Renal Fanconi syndrome (HP:0001994)2.35678538
40Progressive macrocephaly (HP:0004481)2.32158949
41Abnormality of the fovea (HP:0000493)2.31205792
42Adactyly (HP:0009776)2.30515952
43Abnormal pupillary function (HP:0007686)2.29666333
44Abnormality of midbrain morphology (HP:0002418)2.28812586
45Molar tooth sign on MRI (HP:0002419)2.28812586
46Bilateral microphthalmos (HP:0007633)2.27658696
47Abnormality of T cell physiology (HP:0011840)2.26473294
48Optic disc pallor (HP:0000543)2.25883046
49Lipid accumulation in hepatocytes (HP:0006561)2.23684842
50Dyschromatopsia (HP:0007641)2.20446035
51Central scotoma (HP:0000603)2.18184806
52Abnormality of T cells (HP:0002843)2.18180326
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17474698
54True hermaphroditism (HP:0010459)2.15867183
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13674236
56Lactic acidosis (HP:0003128)2.13541471
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13202966
58Increased intramyocellular lipid droplets (HP:0012240)2.11818471
59Fibular aplasia (HP:0002990)2.11234048
60Hyperalaninemia (HP:0003348)2.11038186
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11038186
62Abnormality of alanine metabolism (HP:0010916)2.11038186
63CNS hypomyelination (HP:0003429)2.08314070
64Abnormality of the pleura (HP:0002103)2.07921405
65Aplasia/hypoplasia of the uterus (HP:0008684)2.07793604
66Chronic mucocutaneous candidiasis (HP:0002728)2.06295018
67Recurrent cutaneous fungal infections (HP:0011370)2.06295018
68Hepatic necrosis (HP:0002605)2.05475224
69Pigmentary retinal degeneration (HP:0001146)2.04161554
70Abnormality of the prostate (HP:0008775)2.03755255
71Pancreatic fibrosis (HP:0100732)2.01375777
72Severe visual impairment (HP:0001141)1.99712145
73Obstructive lung disease (HP:0006536)1.98381305
74Chronic obstructive pulmonary disease (HP:0006510)1.98381305
75Attenuation of retinal blood vessels (HP:0007843)1.97613780
76Cerebral edema (HP:0002181)1.93527205
77Eosinophilia (HP:0001880)1.93133277
78Abnormal delayed hypersensitivity skin test (HP:0002963)1.91175601
79Abnormality of the pons (HP:0007361)1.89471360
80Tetraparesis (HP:0002273)1.88967583
81Abnormal rod and cone electroretinograms (HP:0008323)1.88638463
82Vasculitis (HP:0002633)1.87828942
83Exertional dyspnea (HP:0002875)1.87126721
84Hypoplasia of the thymus (HP:0000778)1.85960421
85Progressive microcephaly (HP:0000253)1.85870498
86Severe combined immunodeficiency (HP:0004430)1.83315724
87Panhypogammaglobulinemia (HP:0003139)1.82165412
88Abnormality of eosinophils (HP:0001879)1.82008099
89Short 1st metacarpal (HP:0010034)1.80361338
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80361338
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78938893
92Recurrent sinusitis (HP:0011108)1.78806822
93Thyroiditis (HP:0100646)1.75941542
94Abnormality of proline metabolism (HP:0010907)1.75581227
95Hydroxyprolinuria (HP:0003080)1.75581227
96Palpitations (HP:0001962)1.75511066
97Increased muscle lipid content (HP:0009058)1.74851665
98Unilateral renal agenesis (HP:0000122)1.73036398
99Ureteral stenosis (HP:0000071)1.72443867
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71896595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.93373113
2VRK24.47845395
3TAOK34.05070523
4MAP3K123.71078159
5TLK13.22401240
6STK163.21087650
7NUAK12.76568897
8BMPR1B2.75924331
9TXK2.49985631
10TAF12.29677602
11TIE12.16211886
12GRK12.09496902
13VRK12.04628518
14MST42.04589223
15ADRBK21.92146062
16CSNK1G31.80683446
17CSNK1A1L1.78299835
18MYLK1.63442448
19CSNK1G11.60240393
20PIK3CA1.51682038
21CSNK1G21.45084555
22ACVR1B1.44597308
23DYRK21.42831504
24STK38L1.35047744
25PDK21.31746469
26MAP2K61.24101939
27CDK81.23903112
28KDR1.22980025
29EPHA31.20393535
30GRK51.20076704
31BCKDK1.13866229
32WNK31.09485070
33DAPK11.09359572
34BUB11.04949220
35ITK1.03179747
36NLK0.99846746
37EIF2AK10.93744109
38EIF2AK30.93119289
39MAP4K10.90082390
40ILK0.88785611
41WNK40.87023526
42TGFBR10.85972010
43MATK0.83376455
44PRKCQ0.82744409
45LMTK20.82691564
46ZAK0.81947609
47SRPK10.76448595
48LIMK10.76256125
49SMG10.75733589
50PINK10.75229970
51DAPK20.75052589
52ARAF0.73370811
53MAPKAPK50.72643318
54TESK20.70511143
55IKBKB0.70489216
56MAP3K90.67472730
57NME10.67362748
58MAP3K110.66524598
59ERBB20.65343740
60PTK2B0.61271460
61RIPK40.57166855
62DAPK30.56507311
63FES0.54295474
64ADRBK10.52409398
65FER0.49954734
66PRKCE0.49768637
67NTRK10.49080555
68PLK30.49028801
69CSNK1A10.47195184
70INSRR0.47074998
71FRK0.45712644
72CSK0.45522676
73TEC0.43508515
74TSSK60.43044303
75EIF2AK20.40612672
76PRKCG0.39125018
77NEK10.38332894
78TRIM280.38126568
79PHKG20.36288048
80PHKG10.36288048
81SYK0.35152433
82OXSR10.34937631
83CAMK2A0.34015900
84PBK0.33840363
85EPHB10.31965515
86MAPK130.30850508
87PRKCI0.30497318
88MAP3K40.30455774
89CCNB10.29038136
90TNK20.27526608
91GSK3A0.26738150
92PRKCA0.26384881
93CDK190.25448066
94TYRO30.24203268
95MINK10.22830208
96PLK40.22544454
97STK240.22529678
98GRK70.21727676
99MAP2K70.21520843
100AURKA0.20940887

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.12053966
2Asthma_Homo sapiens_hsa053103.56541704
3Allograft rejection_Homo sapiens_hsa053303.42802634
4Autoimmune thyroid disease_Homo sapiens_hsa053203.33631702
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.23281080
6Oxidative phosphorylation_Homo sapiens_hsa001903.21236131
7Protein export_Homo sapiens_hsa030603.18241027
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.94666819
9Parkinsons disease_Homo sapiens_hsa050122.59250195
10Primary immunodeficiency_Homo sapiens_hsa053402.38547501
11Graft-versus-host disease_Homo sapiens_hsa053322.37549997
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05232548
13Alzheimers disease_Homo sapiens_hsa050101.97631290
14RNA polymerase_Homo sapiens_hsa030201.97565826
15Type I diabetes mellitus_Homo sapiens_hsa049401.93680573
16Antigen processing and presentation_Homo sapiens_hsa046121.91083982
17Huntingtons disease_Homo sapiens_hsa050161.78043415
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64073466
19Phototransduction_Homo sapiens_hsa047441.63425589
20Sulfur metabolism_Homo sapiens_hsa009201.50690629
21Ribosome_Homo sapiens_hsa030101.44677647
22Rheumatoid arthritis_Homo sapiens_hsa053231.42698926
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39107312
24Basal transcription factors_Homo sapiens_hsa030221.37093172
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35173395
26Cardiac muscle contraction_Homo sapiens_hsa042601.24133947
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23737805
28Viral myocarditis_Homo sapiens_hsa054161.16913914
29Nucleotide excision repair_Homo sapiens_hsa034201.14776919
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12687932
31Linoleic acid metabolism_Homo sapiens_hsa005911.09369927
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03436543
33Collecting duct acid secretion_Homo sapiens_hsa049661.02712448
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02598028
35SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99435746
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97965901
37Homologous recombination_Homo sapiens_hsa034400.97779130
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96689112
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96260955
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95528575
41Pyrimidine metabolism_Homo sapiens_hsa002400.90984702
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90143778
43Nitrogen metabolism_Homo sapiens_hsa009100.87034962
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85256712
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81290943
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.81193355
47Pyruvate metabolism_Homo sapiens_hsa006200.79908119
48Chemical carcinogenesis_Homo sapiens_hsa052040.78795097
49Peroxisome_Homo sapiens_hsa041460.78714424
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77149256
51Staphylococcus aureus infection_Homo sapiens_hsa051500.77064891
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.76374416
53Propanoate metabolism_Homo sapiens_hsa006400.75804348
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74975293
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74851868
56Arachidonic acid metabolism_Homo sapiens_hsa005900.73805872
57Fatty acid biosynthesis_Homo sapiens_hsa000610.72303120
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71269104
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70339733
60RNA degradation_Homo sapiens_hsa030180.68249653
61Glutathione metabolism_Homo sapiens_hsa004800.64104194
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63124487
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61684812
64Regulation of autophagy_Homo sapiens_hsa041400.60026467
65Hematopoietic cell lineage_Homo sapiens_hsa046400.58399696
66Caffeine metabolism_Homo sapiens_hsa002320.58353227
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58291830
68Fat digestion and absorption_Homo sapiens_hsa049750.55229811
69Mismatch repair_Homo sapiens_hsa034300.54972268
70Metabolic pathways_Homo sapiens_hsa011000.54368565
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54307297
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.54123035
73One carbon pool by folate_Homo sapiens_hsa006700.53789003
74Retinol metabolism_Homo sapiens_hsa008300.52501640
75Systemic lupus erythematosus_Homo sapiens_hsa053220.50991057
76Olfactory transduction_Homo sapiens_hsa047400.50284195
77Tryptophan metabolism_Homo sapiens_hsa003800.48045429
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.47654682
79N-Glycan biosynthesis_Homo sapiens_hsa005100.46076357
80Fatty acid elongation_Homo sapiens_hsa000620.43631546
81Steroid biosynthesis_Homo sapiens_hsa001000.42614038
82Purine metabolism_Homo sapiens_hsa002300.42216767
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41131440
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39195348
85GABAergic synapse_Homo sapiens_hsa047270.37951596
86Renin-angiotensin system_Homo sapiens_hsa046140.37053375
87Ether lipid metabolism_Homo sapiens_hsa005650.35793517
88Epstein-Barr virus infection_Homo sapiens_hsa051690.35447011
89Sulfur relay system_Homo sapiens_hsa041220.34140480
90Vitamin B6 metabolism_Homo sapiens_hsa007500.33964761
91Morphine addiction_Homo sapiens_hsa050320.33946916
92Taste transduction_Homo sapiens_hsa047420.33262716
93Non-homologous end-joining_Homo sapiens_hsa034500.30036994
94Butanoate metabolism_Homo sapiens_hsa006500.29947146
95Nicotine addiction_Homo sapiens_hsa050330.28302770
96Spliceosome_Homo sapiens_hsa030400.27057321
97Folate biosynthesis_Homo sapiens_hsa007900.26499130
98RNA transport_Homo sapiens_hsa030130.25524840
99Glycerolipid metabolism_Homo sapiens_hsa005610.25468618
100Ovarian steroidogenesis_Homo sapiens_hsa049130.25367944

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